MAGAININ PHARMACEUTICALS INC
S-8, 1996-08-27
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
     As filed with the Securities and Exchange Commission on August 27, 1996
                                                Registration NO.333-
- --------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549
                                  
                                  
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933
                                  
                                  
                          MAGAININ PHARMACEUTICALS INC.
               (Exact name of issuer as specified in its charter)
                                  
        Delaware                                         13-3445668 
 (State or other jurisdiction of            (I.R.S. Employer Identification No.)
 incorporation or organization)

                                5110 Campus Drive
                           Plymouth Meeting, PA 19462
                    (Address of principal executive offices)

                             1992 STOCK OPTION PLAN
                            (Full title of the plans)

                                   JAY MOORIN
                             Chairman, President and
                             Chief Executive Officer
                          Magainin Pharmaceuticals Inc.
                                5110 Campus Drive
                           Plymouth Meeting, PA 19462
                     (Name and address of agent for service)

                                 (610) 941-4020
          (Telephone number, including area code, of agent for service)


                                    Copy to:
                                  DAVID R. KING
                           Morgan, Lewis & Bockius LLP
                              2000 One Logan Square
                           Philadelphia, PA 19103-6993
                                 (215) 963-5371

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
<S>                             <C>                          <C>                 <C>                      <C>   
- ------------------------------  ---------------------------- ------------------  ------------------------ ------------------
      Title of securities               Amount to be          Proposed maximum       Proposed maximum         Amount of
    to be registered under            registered under         offering price       aggregate offering     registration fee
    1992 Stock Option Plan         1992 Stock Option Plan        per share*               price*
- ------------------------------  ---------------------------- ------------------  ------------------------ ------------------
         Common Stock,
par value $.002 per share                 1,000,000                $11.281               $11,281,000              $3,890
==============================  ============================ ==================  ======================== ==================
</TABLE>

(*)      Estimated pursuant to paragraphs (c) and (h) of Rule 457 solely for the
         purpose of calculating the registration fee, based upon the average of
         the reported high and low sales prices of shares of Common Stock on
         August 26, 1996, as reported on the Nasdaq National Market.
<PAGE>   2
                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

                  The following documents, as filed by Magainin Pharmaceuticals
Inc. ("the Company") with the Securities and Exchange Commission, are
incorporated by reference in this Registration Statement and made a part hereof:

                              (a) The Company's latest annual report, filed
             pursuant to Section 13(a) or 15(d) of the Securities Exchange Act
             of 1934 (the "Exchange Act").

                              (b) All other reports filed pursuant to Section 
             13(a) or 15(d) of the Exchange Act since the end of the fiscal year
             covered by the annual report referred to in (a) above.

                              (c) The description of the Common Stock of the
             Company contained in a registration statement filed under the
             Exchange Act, including any amendment or report filed for the
             purpose of updating such description.

                  All reports and other documents subsequently filed by the
Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act,
prior to the filing of a post-effective amendment that indicates that all
securities offered hereby have been sold or that deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference herein and to
be part hereof from the date of filing of such documents. Any statement
contained in any document, all or a portion of which is incorporated by
reference herein, shall be deemed to be modified or superseded for purposes of
this Registration Statement to the extent that a statement contained or
incorporated by reference herein modifies or supersedes such statement. Any
statement so modified or superseded shall not be deemed, except as so modified
or superseded, to constitute a part of this Registration Statement.


ITEM 4.  DESCRIPTION OF SECURITIES.

                      Not applicable.


ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

                      Not applicable.


ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

                  Section 145 of the Delaware General Corporation Law ("Section 
145") permits indemnification of directors, officers, agents and controlling
persons of a corporation under certain conditions and subject to certain
limitations. Article 9 of the Company's By-laws provides for the indemnification
of directors, officers, employees and agents of the Company to the maximum
extent permitted by the Delaware General Corporation Law. Section 145 empowers a
corporation to indemnify any person who was or is a party or is threatened to be
made a party to any threatened, pending or completed action, suit or proceeding,
whether civil, criminal, administrative or investigative, by reason of the fact
that he is or was a director, officer or agent of the corporation or another
enterprise if serving at the request of the corporation. Depending on the
character of the proceeding, a corporation may indemnify against expenses
(including attorneys' fees), judgments, fines and amounts paid in settlement
actually and reasonably incurred in connection with such action, suit or
proceeding if the person indemnified acted in good faith and in a manner he
reasonably believed to be in or not opposed to, the best interests of the
corporation, and, with respect to any criminal
<PAGE>   3
action or proceeding, had no reasonable cause to believe his conduct was
unlawful. In the case of an action by or in the right of the corporation, no
indemnification may be made with respect to any claim, issue or matter as to
which such person shall have been adjudged to be liable to the corporation
unless and only to the extent that the Court of Chancery or the court in which
such action or suit was brought shall determine that despite the adjudication of
liability such person is fairly and reasonably entitled to indemnity for such
expenses which the court shall deem proper. Section 145 further provides that to
the extent a director, officer, employee or agent of a corporation has been
successful in the defense of any action, suit or proceeding referred to above or
in the defense of any claim, issue or matter therein, he shall be indemnified
against expenses (including attorneys' fees) actually and reasonably incurred by
him in connection therewith.

                  The Company's By-laws permit it to purchase insurance on
behalf of any such person against any liability asserted against him and
incurred by him in any such capacity, or arising out of his status as such,
whether or not the Company would have the power to indemnify him against such
liability under the foregoing provision of the By-laws.


ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

                      Not applicable.



ITEM 8.  EXHIBITS.

                      The following is a list of exhibits filed as part of this
Registration Statement.

<TABLE>
<CAPTION>
Exhibit
Number                            Exhibit
- ------                            -------
<S>             <C>                               
  4.1           -     1992 Stock Option Plan, As Amended

  5.1           -     Opinion of Morgan, Lewis & Bockius LLP

 23.1           -     Consent of Richard A. Eisner & Company

 23.2           -     Consent of Morgan, Lewis & Bockius LLP (included as part
                      of Exhibit 5.1)

 25.1           -     Power of Attorney (included as part of the signature page)
</TABLE>


                                        3
<PAGE>   4
ITEM 9.  UNDERTAKINGS.

                      (a)  The undersigned registrant hereby undertakes:

                              (1) To file, during any period in which offers or
sales are being made, a post-effective amendment to this registration statement:

                                       (i) To include any prospectus required by
                      Section 10(a)(3) of the Securities Act of 1933;

                                       (ii) To reflect in the prospectus any
                      facts or events arising after the effective date of the
                      registration statement (or the most recent post-effective
                      amendment thereof) which, individually or in the
                      aggregate, represent a fundamental change in the
                      information set forth in the registration statement; and

                                       (iii) To include any material information
                      with respect to the plan of distribution not previously
                      disclosed in the registration statement or any material
                      change to such information in the registration statement;

                              Provided, however, that paragraphs (a)(1)(i) and
(a)(1)(ii) of this section do not apply if the information required to be
included in a post-effective amendment by those paragraphs is contained in
periodic reports filed by the Company pursuant to Section 13 or Section 15(d) of
the Securities Exchange Act of 1934 that are incorporated by reference in the
registration statement.

                              (2) That, for the purpose of determining any
liability under the Securities Act of 1933, each such post-effective amendment
shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.

                              (3) To remove from registration by means of a
post-effective amendment any of the securities being registered that remain
unsold at the termination of the offering.


                      (b) The undersigned registrant hereby undertakes that, for
the purpose of determining any liability under the Securities Act of 1933, each
filing of the Company's annual report pursuant to Section 13(a) or Section 15(d)
of the Securities Exchange Act of 1934 (and, where applicable, each filing of a
plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of
1934) that is incorporated by reference in this registration statement shall be
deemed to be a new registration statement relating to the securities offered
therein and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.

                      (c) Insofar as indemnification for liabilities arising
under the Securities Act of 1933 may be permitted to directors, officers and
controlling persons of the registrant pursuant to the foregoing provisions, or
otherwise, the registrant has been advised that in the opinion of the Securities
and Exchange Commission such indemnification is against public policy as
expressed in the Act and is, therefore, unenforceable. In the event that a claim
for indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.



                                        4
<PAGE>   5
                                   SIGNATURES

                      Pursuant to the requirements of the Securities Act of
1933, the Company certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the Town of Plymouth Meeting, Commonwealth of Pennsylvania,
on this 16th day of August, 1996.

                                       MAGAININ PHARMACEUTICALS INC.

                                       By:  /s/Jay Moorin
                                            ----------------------------------
                                            Jay Moorin
                                            Chairman, President and Chief 
                                            Executive Officer

                      Pursuant to the requirements of the Securities Act of
1933, this Registration Statement has been signed below by or on behalf of the
following persons in the capacities and on the dates indicated.

                      Each person, in so signing, also makes, constitutes and
appoints Jay Moorin, Chairman, President and Chief Executive Officer, and
Michael R. Dougherty, Executive Vice President and Chief Financial Officer, and
each of such officers acting singly, his true and lawful attorney-in-fact, in
his name, place and stead to execute and cause to be filed with the Securities
and Exchange Commission any or all amendments to this Registration Statement,
with all exhibits and any and all documents required to be filed with respect
thereto, and to do and perform each and every act and thing necessary to
effectuate the same.
<TABLE>
<CAPTION>
Signature                                       Title                                                     Date
- ---------                                       -----                                                     ----
<S>                                             <C>                                                 <C> 
/s/ Jay Moorin                                  Chairman, President and Chief Executive             August 16, 1996
- ----------------------------------------        Officer and Director (Principal
Jay Moorin                                      Executive Officer)

                                                

/s/ Michael R. Dougherty                        Executive Vice President and Chief                  August 16, 1996
- ------------------------------------            Executive Officer
Michael R. Dougherty                            (Principal Financial and Accounting Officer)


/s/ Michael A. Zasloff, M.D., Ph.D.             Vice Chairman, Executive Vice President             August 16, 1996
- -----------------------------------             and Director
Michael A. Zasloff, M.D., Ph.D.                 

                                                                                                    August __, 1996
                                                Director
- -----------------------------------
Bernard Canavan, Ph.D.


/s/ James H. Cavanaugh, Ph.D.                   Director                                            August 16, 1996
- -----------------------------------
James H. Cavanaugh, Ph.D.

/s/ Zola P. Horovitz, Ph.D.                     Director                                            August 16, 1996
- -----------------------------------
Zola P. Horovitz, Ph.D.
</TABLE>
<PAGE>   6
                                INDEX TO EXHIBITS

<TABLE>
<CAPTION>
Exhibit                                                                       Sequentially
Number                                       Exhibit                          Numbered Page
- ------                                       -------                          -------------

<S>               <C>     
  4.1        -    1992 Stock Option Plan, As Amended

  5.1        -    Opinion of Morgan, Lewis & Bockius LLP

 23.1        -    Consent of Richard A. Eisner & Company

 23.2        -    Consent of Morgan, Lewis & Bockius LLP (included as
                  part of Exhibit 5.1)

 25.1        -    Power of Attorney (included as part of the signature page)
</TABLE>



<PAGE>   1
                
                                                                     EXHIBIT 4.1

                          MAGAININ PHARMACEUTICALS INC.

                       1992 STOCK OPTION PLAN, AS AMENDED


Section 1.        Purpose

         The 1992 Stock Option Plan (the "Plan") authorizes the Committee (as
hereafter defined) to provide Non-Employee Directors, Employees and Consultants
of the Corporation and its Subsidiaries, who are in a position to contribute
materially to the long-term success of the Corporation, with options to acquire
common stock of the Corporation in accordance with the terms specified herein.
The Corporation believes that this incentive program will cause those persons to
increase their interest in the Corporation's welfare, and aid in attracting and
retaining Non-Employee Directors, Employees and Consultants of outstanding
ability.

Section 2.        Definitions

         Unless the context clearly indicates otherwise, the following terms,
when used in this Plan, shall have the meanings set forth in this Section :

         (a)      "Board" shall mean the Board of Directors of the Corporation.

         (b)      "Cause" shall mean (i) the Grantee's willful misconduct with
                  respect to the business and affairs of the Corporation or any
                  Subsidiary or affiliate thereof; (ii) the Grantee's gross
                  neglect of duties or failure to act which materially and
                  adversely affects the business or affairs of the Company or
                  any Subsidiary or affiliate thereof; (iii) the Grantee's
                  commission of an act involving embezzlement or fraud or
                  conviction for any felony; or the (iv) the Grantee' breach of
                  an employment or consulting agreement with the Corporation or
                  any Subsidiary or affiliate thereof.

         (c)      "Change in Control" shall mean the occurrence of any of the
                  following: (i) any "person" (as such term is used in Sections 
                  13(d) and 14(d) of the Exchange Act) is or becomes a
                  "beneficial owner" (as defined in Rule 13d-3 under the
                  Exchange Act), directly or indirectly, of securities of the
                  Corporation representing 40% or more of the voting power of
                  the then outstanding securities of the Corporation; (ii)
                  during any period of two consecutive calendar years there is a
                  change of 25% or more in the composition of the Board of the
                  Corporation in office at the beginning of the period except
                  for changes approved by at least two-thirds of the Directors
                  then in office who were Directors at the beginning of the
                  period; (iii) the stockholders of the Corporation approve an
                  agreement providing for (A) the merger or consolidation of the
                  Corporation with another corporation where the stockholders of
                  the Corporation, immediately prior to the merger or
                  consolidation, would not beneficially own, immediately after
                  the merger or consolidation, shares entitling such
                  stockholders to 50% or more of all votes (without
                  consideration of the rights of any class of stock to elect
                  Directors by a separate class vote) to which all stockholders
                  of the corporation issuing cash or securities in the merger or
                  consolidation would be entitled in the election of directors
                  or where the members of the Board, immediately prior to the
                  merger or consolidation, would not, immediately after the
                  merger or consolidation, constitute a majority of the Board of
                  Directors of the corporation issuing cash or securities in the
                  merger or consolidation or (B) the sale or other disposition
                  of all or substantially all the assets of the Corporation, or
                  a liquidation, dissolution or statutory exchange of the
                  Corporation; or (iv) any person has commenced, or announced an
                  intention to commence, a tender offer or exchange offer for
                  40% or more of the voting power of the then-outstanding
                  securities of the Corporation.

         (d)      "Code" shall mean the Internal Revenue Code of 1986 as it may
                  be amended from time to time.

         (e)      "Committee" shall mean a Committee of not less than two
                  Directors who are "Disinterested Persons," as that term is
                  defined and interpreted pursuant to Rule 16b-3 under the
                  Exchange Act. Directors who have received options or
                  Stock-related compensation pursuant to a discretionary award
                  by the Corporation, the Board or by any Subsidiary or
                  affiliate of the Corporation during the one-year period before
                  serving on the Committee or at any time while serving on the
                  Committee shall be disqualified from serving on the Committee
                  and prohibited from serving as 
<PAGE>   2
                  such until at least one-year has passed from the most recent
                  discretionary award; provided, however, the receipt of options
                  automatically awarded to Non-Employee Directors, as provided
                  in Section 6(b) herein, shall not disqualify such Non-Employee
                  Director from serving on the Committee. The Committee shall be
                  appointed by and serve at the pleasure of the Board.

         (f)      "Consultant" shall mean any consultant of the Corporation or
                  its Subsidiaries.

         (g)      "Control Person" shall mean any person who, as of the date of
                  grant of an Option, owns (within the meaning of Section 
                  422(b)(6) of the Code) stock possessing more than ten percent
                  of the total combined voting power or value of all classes of
                  stock of the Corporation or of any parent or Subsidiary.

         (h)      "Corporation" shall mean Magainin Pharmaceuticals Inc., a
                  Delaware corporation.

         (i)      "Director" shall mean any member of the Board.

         (j)      "Employee" shall mean any employee of the Corporation or its
                  Subsidiaries.

         (k)      "Exchange Act" shall mean the Securities Exchange Act of 1934
                  as it may be amended from time to time.

         (l)      "Fair Market Value" shall mean for any day the closing price
                  of the Stock in the over-the-counter market, as reported
                  through the National Association of Securities Dealers
                  Automated Quotation System or, if the Stock is listed or
                  admitted to trading on any national securities exchange, the
                  last reported sale price on such exchange.

         (m)      "Grantee" shall mean a person granted an Option under the
                  Plan.

         (n)      "ISO" shall mean an Option granted pursuant to the Plan to
                  purchase shares of the Stock and intended to qualify as an
                  incentive stock option under Section 422 of the Code, as now
                  or hereafter constituted.

         (o)      "NQSO" shall mean an Option granted pursuant to the Plan to
                  purchase shares of the Stock that is not an ISO.

         (p)      "Non-Employee Director" shall mean a Director who is not an
                  employee of the Corporation or any of its Subsidiaries.

         (q)      "Options" shall refer collectively to NQSOs and ISOs subject
                  to the Plan.

         (r)      "Parent" shall mean any parent of the Corporation, as defined
                  in Section 424 of the Code.

         (s)      "Plan" shall mean this 1992 Stock Option Plan as set forth
                  herein and as amended from time to time.

         (t)      "Stock" shall mean shares of the Common Stock of the
                  Corporation.

         (u)      "Subsidiary" shall mean any subsidiary corporation as defined
                  in Section 424 of the Code.

Section 3.        Shares of Stock Subject to the Plan

         Subject to the provisions of Section 8, the Stock which may be issued
or transferred pursuant to Options granted under the Plan shall not exceed
2,500,000 shares in the aggregate. Notwithstanding anything in the plan to the
contrary, the maximum aggregate number of shares of stock that shall be subject
to options granted to any single individual during the term of the plan shall be
50% of the aggregate number of shares available for issuance under the Plan.
Stock issuable upon the exercise of any Option may be authorized but unissued
shares or reacquired shares of Stock. If any unexercised Options lapse or
terminate for any reason, the Stock covered thereby may again be optioned. More
than one Option may be granted to one person.
<PAGE>   3
Section 4.        Administration of the Plan

         The Plan shall be administered by the Committee. Subject to the express
provisions of the Plan, the Committee shall have the authority to interpret the
Plan, to prescribe, amend, and rescind rules and regulations relating to the
Plan, to determine the terms and provisions of stock option agreements
thereunder and to make all other determinations necessary or advisable for the
administration of the Plan. The Committee shall have the discretion to determine
under the provisions of stock option agreements for Options, that, upon the
occurrence of a Change in Control specified in Section 2(c)(iii) hereof, the
Committee may require the cancellation for cash of outstanding Options or the
issuance of comparable replacement options granted by the surviving entity. Any
controversy or claim arising out of or related to this Plan or the Options
granted thereunder shall be determined unilaterally by, and at the sole
discretion of, the Committee.

Section 5.        Types of Options

         Options granted under the Plan may be of two types: ISOs and NQSOs. The
Committee shall have the authority and discretion to grant to an eligible
Employee either ISOs, NQSOs or both, but shall clearly designate the nature of
each Option at the time of grant. Non-Employee Directors and Consultants shall
only be entitled to receive NQSOs.

Section 6.        Grant of Options to Non-Employee Directors, Employees and 
                  Consultants

         (a)      Non-Employee Directors, Employees and Consultants of the
                  Corporation and its Subsidiaries shall be eligible to receive
                  Options under the Plan.

         (b)      Each Non-Employee Director shall receive a grant of NQSOs in
                  accordance with this clause (b).

                  (1)      Initial Grant: Each Non-Employee Director shall
                           receive a grant of an NQSO to purchase 15,000 shares
                           of Stock upon the following terms and conditions:

                           (i)      As to any such person who becomes a member
                                    of the Board after the date of the
                                    Corporation's 1993 annual meeting of
                                    stockholders, the date of grant shall be the
                                    date he or she first becomes a member of the
                                    Board; and

                           (ii)     As to any such person who is elected at the
                                    Corporation's 1993 annual meeting of
                                    stockholders, the date of grant shall be
                                    such date of the Corporation's 1993 annual
                                    meeting of stockholders.

                  (2)      Annual Grant: On each date that the Corporation holds
                           its annual meeting of stockholders, commencing with
                           the 1994 calendar year, each Non-Employee Director in
                           office immediately after the annual election of
                           directors (other than those Non-Employee Directors
                           who first commence their service as directors upon
                           election by the stockholders at such meeting) shall
                           receive a grant of an NQSO to purchase 5,000 shares
                           of Stock.

                  (3)      Options granted under this subsection (b) shall have
                           a per share exercise price equal to the fair market
                           value of a share of Stock on the date of grant and a
                           term of ten years, and such option shall become
                           exercisable, with respect to 25% of the shares of
                           Stock underlying the option, on each anniversary of
                           the date of grant for a four-year period.
                           Notwithstanding any other provision of the Plan, this
                           subsection may not be amended more than once every
                           six months, except for amendments necessary to
                           conform the Plan to changes in the provisions of or
                           the regulations relating to the Internal Revenue Code
                           or the Employee Retirement Income Security Act of
                           1974.

                  (4)      The provisions of this Section 6(b) are intended to
                           operate automatically and not require administration.
                           However, to the extent that administrative
                           determinations are required, the provisions of this
                           Section 6(b) shall be made by the members of the
                           Board who are not eligible to receive grants under
                           this Section 6(b), but in no event shall such
                           determinations affect the eligibility of optionees,
                           the determination of the exercise price, the timing
                           of the grants or the number of shares subject to
                           options hereunder.
<PAGE>   4
                  (5)      Except as otherwise provided in this Section 6(b),
                           the NQSOs granted to Non-Employee Directors shall be
                           subject to the provisions of this Plan applicable to
                           NQSOs granted to other persons.

         (c)      The exercise price per share of Stock subject to an Option
                  granted to an Employee or Consultant shall be determined by
                  the Committee, provided, however, (i) that the exercise price
                  of each share subject to an ISO shall be not less than 100% of
                  the Fair Market Value of a share of the Stock on the date such
                  ISO is granted, (ii) that the per share exercise price of any
                  ISO granted to a Control Person shall not be less than 110% of
                  the Fair Market Value of a share of Stock on the date such ISO
                  is granted, and (iii) that the exercise price of each share
                  subject to an NQSO shall not be less than 100% of the Fair
                  Market Value of a share of the Stock on the date such NQSO is
                  granted.

         (d)      The term of each Option granted to an Employee or Consultant
                  shall be determined by the Committee, provided that no Option
                  shall be exercisable more than ten years from the date such
                  Option is granted, and provided further that no ISO granted to
                  a Control Person shall be exercisable more than five years
                  from the date of Option grant.

         (e)      The Committee shall determine and designate from time to time
                  the Employees and Consultants who are to be granted Options,
                  the nature of each Option granted and the number of shares of
                  Stock subject to each such Option.

         (f)      Notwithstanding any other provisions hereof, the aggregate
                  Fair Market Value (determined at the time the ISO is granted)
                  of the Stock with respect to which ISOs are exercisable for
                  the first time by any Employee during any calendar year under
                  all plans of the Corporation and any Parent or Subsidiary
                  corporation shall not exceed $100,000.

         (g)      The Committee, in its sole discretion, shall determine whether
                  any Option granted to an Employee or Consultant shall become
                  exercisable in one or more installments and specify the
                  installment dates. The Committee may also make such other
                  provisions, not inconsistent with the terms of this Plan, as
                  it may deem desirable, including such provisions as it may
                  deem necessary to qualify any ISO under the provisions of
                  Section 422 of the Code. The Committee, in its sole
                  discretion, shall have the power to accelerate the period or
                  periods during which Options become exercisable.
                  Notwithstanding any determination by the Committee regarding
                  the exercise period of any Option, all such Options shall
                  immediately become exercisable upon a Change in Control of the
                  Corporation.

         (h)      The Committee may, at any time, grant new or additional
                  options to any eligible Employee or Consultant who has
                  previously received Options under this Plan, or options under
                  other plans, regardless of whether such prior Options or other
                  options are still outstanding, have been exercised previously
                  in whole or in part, or have been cancelled. The exercise
                  price of such new or additional Options may be established by
                  the Committee, subject to Section 6(c) hereof, without regard
                  to such previously granted Options or other options.

Section 7.        Exercise of Options

         (a)      Upon the exercise of any Option, the Grantee shall pay the
                  exercise price for the shares being purchased in the manner
                  provided in the particular stock option agreement, including
                  payment for such shares by the delivery of outstanding shares
                  of Stock or the surrender of shares of Stock (at their Fair
                  Market Value), if permitted by such stock option agreement,
                  including Stock subject to the Option then being exercised.

         (b)      The number of shares which are issued pursuant to the exercise
                  of an Option shall be charged against the maximum limitation
                  on shares set forth in Section 3 hereof.

         (c)      Except as provided in Section 9, no Option granted to a
                  Non-Employee Director, Employee or Consultant shall be
                  exercised unless at the time of such exercise the Grantee is
                  then a Director, Employee or Consultant.
<PAGE>   5
         (d)      Before the Company issues Stock to a Grantee pursuant to the
                  exercise of an NQSO, the Corporation shall have the right to
                  require that the Grantee make such provision, or furnish the
                  Corporation such authorization, necessary or desirable so that
                  the Corporation may satisfy its obligation, under applicable
                  income tax laws, to withhold for income or other taxes due
                  upon or incident to such exercise. The Board may adopt such
                  rules, forms and procedures as it considers necessary or
                  desirable to implement this Section 7(d), which rules, forms
                  and procedures shall be binding upon all Grantees, and which
                  shall be applied uniformly to all Grantees similarly situated.

Section 8.        Adjustment Upon Changes in Capitalization

         In the event of any reclassification, recapitalization, merger,
consolidation, reorganization, issuance of warrants, rights or debentures, stock
dividend, stock split or reverse stock split, cash dividend, property dividend,
combination or exchange of shares, repurchase of shares or any other change in
corporate structure which in the judgment of the Committee materially affects
the value of shares, the Committee may determine the appropriate adjustments, if
any, to the number and class of shares and the exercise price per share set
forth in any Option theretofore granted, provided that no such adjustments shall
be made to any ISO without the Grantee's consent, if such adjustment would cause
such ISO to fail to qualify as such.

Section 9.        Termination of Relationship with the Corporation

         (a)      Upon the termination of a Non-Employee Director's service on
                  the Board, an Employee's employment or a Consultant's
                  consulting relationship with the Corporation for any reason
                  (except in the case of termination for Cause whereupon such
                  Options shall immediately terminate), such Grantee may
                  exercise any outstanding and then exercisable installments of
                  his or her Options for a three-month period from the date of
                  such termination or such longer period as set forth in this
                  Section 9(a), provided, however, that in no event shall the
                  period in which such Options may be exercised hereunder extend
                  beyond the expiration of the Option term. The Committee shall
                  have the discretion to provide that upon termination of a
                  Non-Employee Director's service on the Board, an Employee's
                  employment or a Consultant's consulting relationship as a
                  result of death or permanent and total disability (within the
                  meaning of Section 22(e)(3) of the Code), such Grantee or his
                  or her legal representative may exercise any outstanding and
                  then exercisable installments of his or her Options for a
                  period not to exceed one year from the date of such
                  termination. In no event shall any Option be exercisable for
                  more than the maximum number of shares that the Grantee was
                  entitled to purchase at the date of termination, retirement,
                  disability, or death as the case may be. In the case of an
                  Employee or Consultant, the transfer among the Corporation and
                  any Subsidiary shall not be deemed to be a termination of the
                  employment or consulting relationship. Notwithstanding the
                  above, a change from the status of a Non-Employee Director to
                  an Employee or Consultant, an Employee to a Consultant or a
                  Consultant to an Employee shall not result in the termination
                  of an Option in accordance with the foregoing provisions and
                  such Option shall remain outstanding, subject to its original
                  terms and the provisions of this Plan.

         (b)      Subject to the foregoing, in the event of death, Options may
                  be exercised by a Grantee's legal representative.

Section 10.       General Provisions

         (a)      Each Option grant shall be evidenced by a written stock option
                  agreement containing such terms and conditions, not
                  inconsistent with this Plan, as the Committee shall approve.
                  ISOs and NQSOs may be granted to Employees simultaneously and
                  subject to a single stock option agreement, provided, however,
                  that in no event shall a NQSO be granted in tandem with an ISO
                  such that the exercise of one affects the right to exercise
                  the other. The terms and provisions of such stock option
                  agreements (including the exercise price specified therein)
                  may vary among Grantees and among different Options granted to
                  the same Grantee.

         (b)      The grant of an Option in any year shall not give the Grantee
                  any right to similar grants in future years or any right to
                  continue such Grantee's service on the Board, employment or
                  consultant relationship with the Corporation or its
                  Subsidiaries. All Grantees shall remain subject to discharge
                  to the same extent as if the Plan were not in effect.
<PAGE>   6
         (c)      No Grantee, and no beneficiary or other persons claiming under
                  or through the Grantee shall have any right, title or interest
                  by reason of any Option to any particular assets of the
                  Corporation or its Subsidiaries, or any shares of Stock
                  allocated or reserved for the purposes of the Plan or subject
                  to any Option except as set forth herein. The Corporation
                  shall not be required to establish any fund or make any other
                  segregation of assets to assure the payment of any Option.

         (d)      No Option or other right under the Plan shall be transferable
                  or subject to anticipation, sale, assignment, pledge,
                  encumbrance, or charge, except by will or the laws of descent
                  and distribution, and an Option shall be exercisable during
                  the Grantee's lifetime only by the Grantee.

         (e)      Notwithstanding any other provision of this Plan or stock
                  option agreements made pursuant thereto, the Corporation shall
                  not be required to issue or deliver any certificate or
                  certificates for shares of Stock under this Plan prior to
                  fulfillment of all of the following conditions:

                  (1)      The listing, or approval for listing upon notice of 
                           issuance, of such shares on any securities
                           exchange on which the Stock may then be traded;

                  (2)      Any registration or other qualification of such
                           shares under any state or federal law or regulation,
                           or other qualification which the Board shall, in its
                           absolute discretion and upon the advice of counsel,
                           deem necessary or advisable;

                  (3)      The obtaining of any other consent, approval or
                           permit from any state or federal governmental agency
                           which the Board shall, in its absolute discretion and
                           upon the advice of counsel, determine to be necessary
                           or advisable; and

                  (4)      The execution by the Grantee (or the Grantee's legal
                           representative) of such written representation that
                           the Committee may in its sole discretion deem
                           necessary or advisable to the effect that the shares
                           then being purchased are being purchased for
                           investment with no present intention of reselling or
                           otherwise disposing of such shares in any manner
                           which may result in a violation of the Securities Act
                           of 1933, as amended, and the placement upon
                           certificates for such shares of an appropriate legend
                           in connection therewith.

         (f)      The issuance of shares of Stock to Grantees or to their legal
                  representatives shall be subject to any applicable taxes and
                  other laws or regulations of the United States or of any state
                  having jurisdiction thereof.

         (g)      In the case of a grant of an Option to any Employee or
                  Consultant of a Subsidiary, the Corporation may, if the
                  Committee so directs, issue or transfer the shares covered by
                  the Option to the Subsidiary, for such lawful consideration as
                  the Committee may specify, upon the condition or understanding
                  that the Subsidiary will transfer the shares to the Employee
                  or Consultant in accordance with the terms of the Plan and the
                  stock option agreement relating to such Option.

Section 11.       Amendment or Termination

         The Committee may, at any time, alter, amend, suspend, discontinue or
terminate this Plan; provided, however, that no such action shall adversely
affect the rights of Grantees to Options previously granted hereunder and,
provided further, however, that any shareholder approval necessary or desirable
in order to comply with Rule 16b-3 under the Exchange Act or with Section 422 of
the Code (or other applicable law or regulation) shall be obtained in the manner
required therein.

Section 12.       Duration of Plan

         This Plan was effective upon its adoption by the Board on May 5, 1992,
subject to the approval of the Corporation's stockholders at the next annual
meeting following such adoption. This Plan as amended is effective upon its
adoption by the Board on March 25, 1996, subject to the approval of such
amendment by the Corporation's stockholders at the next annual meeting following
such adoption. This Plan shall terminate at the close of business on May 5,
2002, and no Option may be granted under the Plan thereafter, but such
termination shall not affect any Options theretofore granted.



<PAGE>   1
                                                                    EXHIBIT 5.1


                           Morgan, Lewis & Bockius LLP
                                Counselors at Law
                              2000 One Logan Square
                      Philadelphia, Pennsylvania 19103-6993
                            Telephone: (215) 963-5000
                               Fax: (215) 963-5299




August 27, 1996

Magainin Pharmaceuticals Inc.
5110 Campus Drive
Plymouth Meeting, PA 19462

Re:      Magainin Pharmaceuticals Inc.
         Registration Statement on Form S-8
         Relating to the Company's 1992 Stock Option Plan

Ladies and Gentlemen:

We have acted as counsel to Magainin Pharmaceuticals Inc., a Delaware
corporation (the "Company"), in connection with the preparation of a
registration statement on Form S-8 (the "Registration Statement") filed with the
Securities and Exchange Commission under the Securities Act of 1933, as amended
(the "Act"), relating to the offering of up to 1,000,000 shares of Common Stock
to be issued pursuant to stock options to be granted under the Magainin
Pharmaceuticals Inc. 1992 Stock Option Plan, as amended (the "1992 Plan"), and
which represent the registration of additional shares of Common Stock for which
Registration Statements filed on Form S-8 (Registration Nos. 33-52882 and
33-71984) relating to the same employee benefit plan are effective. We have
examined such records, documents, statutes and decisions as we have deemed
relevant in rendering this opinion. In our examination we have assumed the
genuineness of documents submitted to us as originals and the conformity with
the original of all documents submitted to us as copies thereof.

In our opinion, the shares of the Company's Common Stock to be issued upon
exercise of the options granted or to be granted in accordance with the terms of
the 1992 Plan will be, when issued in accordance with the terms of the 1992 Plan
for a price not less than the par value thereof, validly issued, fully paid and
nonassessable shares of the Common Stock of the Company.

The opinion set forth above is limited to the General Corporation Law of the
State of Delaware.
<PAGE>   2
Magainin Pharmaceuticals Inc.
August 27, 1996
Page 2

We hereby consent to the use of this opinion as Exhibit 5.1 to the Registration
Statement. In giving such opinion, we do not thereby admit that we are acting
within the category of persons whose consent is required under Section 7 of the
Act or the rules or regulations of the Securities and Exchange Commission
thereunder.

Very truly yours,

MORGAN, LEWIS & BOCKIUS LLP





<PAGE>   1
                                                                    EXHIBIT 23.1




                         CONSENT OF INDEPENDENT AUDITORS


                  We consent to the incorporation by reference in the
Registration Statement on Form S-8 of our report dated January 26, 1996 on the
financial statements included in the annual report of Magainin Pharmaceuticals
Inc. as at and for the year ended December 31, 1995. 



Richard A. Eisner & Company, LLP

New York, New York
August 26, 1996




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