<PAGE>
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. 3 )*
Magainin Pharmaceuticals Inc.
---------------------------------------------
(Name of Issuer)
Common Stock, $.002 par value
---------------------------------------------
(Title of Class of Securities)
559036108
---------------------------------------------
(CUSIP Number)
Check the following box if a fee is being paid with this statement [ ]. (A fee
is not required only if the filing person: (1) has a previous statement on file
reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)
* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
(Continued on following page(s))
Page 1 of 15 Pages
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- ------------------------------- -----------------------------
CUSIP NO. 559036108 13G Page 2 of 15 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Ventures I, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF
SHARES ----------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH 361,845
REPORTING
PERSON ----------------------------------------------------
WITH
7 SOLE DISPOSITIVE POWER
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
361,845
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
361,845
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
1.9%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 559036108 13G Page 3 of 15 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Partners I, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF
SHARES ----------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH 389,790
REPORTING
PERSON ----------------------------------------------------
WITH
7 SOLE DISPOSITIVE POWER
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
389,790
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
389,790
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 559036108 13G Page 4 of 15 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Ventures II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF
SHARES ----------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH 145,131
REPORTING
PERSON ----------------------------------------------------
WITH
7 SOLE DISPOSITIVE POWER
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
145,131
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
145,131
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
.7%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 559036108 13G Page 5 of 15 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Partners II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF
SHARES ----------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH 145,131
REPORTING
PERSON ----------------------------------------------------
WITH
7 SOLE DISPOSITIVE POWER
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
145,131
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
145,131
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
.7%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 559036108 13G Page 6 of 15 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
James H. Cavanaugh, Ph.D.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF 2,321
SHARES ----------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH 534,921
REPORTING
PERSON ----------------------------------------------------
WITH
7 SOLE DISPOSITIVE POWER
2,321
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
534,921
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
534,921
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
2.8%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 559036108 13G Page 7 of 15 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
Harold R. Werner
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF 4,859
SHARES ----------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH 534,921
REPORTING
PERSON ----------------------------------------------------
WITH
7 SOLE DISPOSITIVE POWER
4,859
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
534,921
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
534,921
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
2.8%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 559036108 13G Page 8 of 15 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
John W. Littlechild
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF
SHARES ----------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH 534,921
REPORTING
PERSON ----------------------------------------------------
WITH
7 SOLE DISPOSITIVE POWER
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
534,921
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
534,921
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
2.7%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 559036108 13G Page 9 of 15 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
William Crouse
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF
SHARES ----------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH 534,921
REPORTING
PERSON ----------------------------------------------------
WITH
7 SOLE DISPOSITIVE POWER
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
534,921
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
534,921
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE OF CLASS REPRESENTED BY AMOUNT IN ROW 9
2.7%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
Page 10 of 15 Pages
Item 1.
(a) Name of Issuer:
Magainin Pharmaceuticals Inc.
(b) Address of Issuer's Principal Executive Offices:
5110 Campus Drive
Plymouth Meeting, Pennsylvania 19462
Item 2.
(a) Name of Person Filing:
HealthCare Ventures I, L.P. ("HCV I"), HealthCare Partners I,
L.P. ("HCP I"), HealthCare Ventures II, L.P. ("HCV II"),
HealthCare Partners II, L.P. ("HCP II"), Dr. Cavanaugh and
Messrs. Werner, Littlechild and Crouse. See attached Exhibit A
which is a copy of their agreement in writing to file this
statement on behalf of each of them.(1)
(b) Address of Principal Business Office or, if none, Residence:
The business address for HCV I, HCP I, HCV II, HCP II, Dr.
Cavanaugh and Messrs. Werner and Crouse is Twin Towers at
Metro Park, 379 Thornall Street, Edison, New Jersey 08837. The
business address for Mr. Littlechild is One Kendall Square,
Building 300, Cambridge, Massachusetts 02139.
(c) Citizenship:
HCV I, HCP I, HCV II and HCP II are limited partnerships
organized under the laws of the State of Delaware. Dr.
Cavanaugh and Messrs. Werner, Littlechild and Crouse are each
United States citizens.
(d) Title of Class of Securities:
Common Stock, par value $.01 ("Shares").
- --------
(1) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are
general partners of HCP I and HCP II, which are the general
partners of HCV I and HCV II, respectively, the record holder
of Issuer's securities.
<PAGE>
Page 11 of 15 Pages
(e) CUSIP Number:
559036108
Item 3. If this statement is filed pursuant to Rule 13d-1(b), or
13d-2(b), check whether the person filing is a:
Inapplicable.
Item 4. Ownership.
(a) Amount Beneficially Owned:
As of December 31, 1996: HCV I beneficially owned 361,845
Shares of Issuer's Securities, consisting of 259,526 Shares of
Issuer's Common Stock and immediately exercisable warrants to
purchase 102,319 Shares of Issuer's Common Stock; HCP I
beneficially owned 389,790 Shares of Issuer's Securities,
consisting of 287,471 Shares of Issuer's Common Stock and
immediately exercisable warrants to purchase 102,319 Shares of
Issuer's Common Stock; HCV II and HCP II beneficially owned
145,131 Shares of Issuer's Securities consisting of 106,234
Shares of Issuer's Common Stock and immediately exercisable
warrants to purchase 38,897 Shares of Issuer's Common Stock;
Dr. Cavanaugh beneficially owned 537,242 Shares of Issuer's
Securities, consisting of 396,026 Shares of Issuer's Common
Stock and immediately exercisable warrants to purchase 102,319
Shares of Issuer's Common Stock; Mr. Werner beneficially owned
539,780 Shares of Issuer's Securities, consisting of 398,564
Shares of Issuer's Common Stock and immediately exercisable
warrants to purchase 102,319 Share of Issuer's Common Stock;
and Messrs. Littlechild and Crouse beneficially owned 534,921
Shares of Issuer's Securities, consisting of 445,236 Shares of
Issuer's Common Stock and immediately exercisable warrants to
purchase 141,216 Shares of Issuer's Common Stock.
(b) Percent of Class:
As of December 31, 1996: the 361,845 Shares of Issuer's
Securities beneficially owned by HCV I constitute 1.9% of
Issuer's Shares outstanding; the 389,790 Shares of Issuer's
Securities beneficially owned by HCP I constitute 2% of
Issuer's Shares outstanding; the 145,131 Shares of Issuer's
Securities beneficially owned by HCV II and HCP II constitute
.7% of Issuer's Shares outstanding; the 537,242 Shares of
Issuer's Securities beneficially owned by Dr. Cavanaugh
constitute 2.8% of Issuer's Shares outstanding; the 539,780
Shares of Issuer's Securities beneficially owned by Mr. Werner
constitutes 2.8% of Issuer's Shares outstanding; and the
534,921 Shares of Issuer's Securities beneficially owned by
Messrs. Littlechild and Crouse constitute 2.7% of Issuer's
Shares outstanding.
<PAGE>
Page 12 of 15
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
Dr. Cavanaugh has the sole power to vote or direct
the vote of the 2,321 Shares of Issuer's Common Stock
beneficially owned by him.
Mr. Werner has the sole power to vote or direct the
vote of the 4,859 Shares of Issuer's Common Stock
beneficially owned by him.
(ii) shared power to vote or to direct the vote:
HCV I, HCP I, Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse share the power to vote or
direct the vote of those Shares owned by HCV I and
Dr. Cavanaugh and Messrs. Werner, Littlechild and
Crouse share the power to vote or direct the vote of
those Shares owned by HCP I.
HCV II, HCP II and Messrs. Cavanaugh, Werner,
Littlechild and Crouse share the power to vote or to
direct the vote of those Shares owned by HCV II.
(iii) sole power to dispose or to direct the disposition
of:
Dr. Cavanaugh has the sole power to dispose of or
direct the disposition of the 2,321 Shares of
Issuer's Common Stock beneficially owned by him.
Mr. Werner has the sole power to dispose of or direct
the disposition of the 4,859 Shares of Issuer's
Common Stock beneficially owned by him.
(iv) shared power to dispose of or to direct the
disposition of:
HCV I, HCP I, Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse share the power to dispose of
or direct the disposition of those Shares owned by
HCV I and Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse share the power to dispose of
or direct the disposition of those Shares owned by
HCP I.
<PAGE>
Page 13 of 15 Pages
HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse share the power to dispose of
or to direct the disposition of those Shares owned by
HCV II.
Item 5. Ownership of Five Percent or less of a Class:
If this statement is being filed to report the fact that as of
the date hereof the reporting person has ceased to be the
beneficial owner of more than five percent of the Class of the
Securities, check the following [X].
Item 6. Ownership of More than Five Percent on Behalf of Another
Person:
Inapplicable.
Item 7. Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on by the Parent Holding
Company:
Inapplicable.
Item 8. Identification and Classification of Members of the Group:
Inapplicable.
Item 9. Notice of Dissolution of Group:
Inapplicable.
Item 10. Certification:
Inapplicable.
<PAGE>
Page 14 of 15 Pages
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
Dated: February 13, 1997 HealthCare Ventures I, L.P.,
Edison, New Jersey by its General Partner,
HealthCare Partners I, L.P.
By: /s/ Jeffrey Steinberg
------------------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners I, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
------------------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Ventures II, L.P.,
Edison, New Jersey by its General Partner
HealthCare Partners II, L.P.
By: /s/ Jeffrey Steinberg
------------------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners II, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
------------------------------------------
Administrative Partner
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
Edison, New Jersey -----------------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
Edison, New Jersey -----------------------------------------
Harold R. Werner
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
Cambridge, -----------------------------------------
Massachusetts John W. Littlechild
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
Edison, New Jersey -----------------------------------------
William Crouse
<PAGE>
Page 15 of 15 Pages
EXHIBIT A
AGREEMENT
JOINT FILING OF SCHEDULE 13G
The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13G and any future amendments thereto
reporting each of the undersigned's ownership of securities of Magainin
Pharmaceuticals Inc. and hereby affirm that such Schedule 13G is being filed on
behalf of each of the undersigned.
Dated: February 13, 1997 HealthCare Ventures I, L.P.,
Edison, New Jersey by its General Partner,
HealthCare Partners I, L.P.
By: /s/ Jeffrey Steinberg
-----------------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners I, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Ventures II, L.P.,
Edison, New Jersey by its General Partner
HealthCare Partners II, L.P.
By: /s/ Jeffrey Steinberg
-----------------------------------------
Administrative Partner
Dated: February 13, 1997 HealthCare Partners II, L.P.
Edison, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------------------
Administrative Partner
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
Edison, New Jersey -----------------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
Edison, New Jersey -----------------------------------------
Harold R. Werner
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
Cambridge, -----------------------------------------
Massachusetts John W. Littlechild
Dated: February 13, 1997 By: /s/ Jeffrey Steinberg as Attorney-in-Fact
Edison, New Jersey -----------------------------------------
William Crouse
