MAGAININ PHARMACEUTICALS INC
5, 1999-02-12
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>
 
 
                    U.S. SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549


              ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

FORM 5                                                      OMB APPROVAL
                                                   -----------------------------
[_] Check this box if no longer                    OMB NUMBER:  3235-0362
    subject to Section 16. Form 4                  Expires:  September 30, 1998
    or Form 5 obligations may                      Estimated average burden
    continue. SEE Instruction 1(b).                hours per response ...... 1.0
                                                   -----------------------------
[_] Form 3 Holdings Reported

[_] Form 4 Transaction Reported


              ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP



    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
      Section 17(a) of the Public Utility Holding Company Act of 1935 or
              Section 30(f) of the Investment Company Act of 1940




1. Name and Address of Reporting Person

Bigger,                               Thomas                            J.
- --------------------------------------------------------------------------------
  (Last)                             (First)                         (Middle)

c/o Magainin Pharmaceutical, Inc. 5110 Campus Drive
- --------------------------------------------------------------------------------
                                    (Street)

Plymouth Meeting,                       PA                            19462
- --------------------------------------------------------------------------------
  (City)                             (State)                          (Zip)


- --------------------------------------------------------------------------------
2. Issuer Name and Ticker or Trading Symbol

Maganin Pharmaceuticals, Inc. -- MAGN
- --------------------------------------------------------------------------------
3. IRS Number of Reporting Person (Voluntary)


- --------------------------------------------------------------------------------
4. Statement for Month/Year

12/98
- --------------------------------------------------------------------------------
5. If Amendment, Date of Original   (Month/Day/Year)


- --------------------------------------------------------------------------------
6. Relationship of Reporting Person to Issuer
       (Check all applicable)


                  Director                         10% Owner
           -----                           ------ 

             X    Officer (give                    Other (Specify
           -----           title below)    ------         below)

        Senior Vice-President, Business Development, Marketing & Sales
        -------------------------------------------------------------- 
- --------------------------------------------------------------------------------
7. Individual or Joint/Group Reporting
        (Check applicable line)

  X   Form Filed by One Reporting Person
- -----
      Form Filed by More than One Reporting Person
- -----


<TABLE> 
<CAPTION> 
                         Table 1 -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1. Title of Security        2. Trans-   3. Trans-      4. Securities Acquired (A)  5. Amount of        6. Ownership  7. Nature
   (Instr. 3)                  action      action         or Disposed of (D)          Securities          Form:         of Indirect 
                               Date        Code                                       Beneficially        Direct        Beneficial
                                          (Instr. 8)      (Instr. 3,4 and 5)          Owned at End       (D) or         Ownership
                              (Month/                  --------------------------     Of Issuer's         Indirect     (Instr. 4)
                               Day/                     Amount   (A) or    Price      Fiscal Year        (I)      
                               Year)                             (D)                 (Instr. 3 and 4)    (Instr. 4)
- --------------------------  ----------  ------  ----   --------  ------    ------   ----------------   ------------  ------------- 
<S>                           <C>         <C>     <C>    <C>       <C>       <C>        <C>            <C>           <C> 
None
- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 

- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 

- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 

- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 

- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 

- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 

- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 

- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 

- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 

- --------------------------    ----------  ------  ----   --------  ------    ------     -------------- ------------  ------------- 
</TABLE> 

*If the form is filed                   Potential persons who are to respond to 
by more than one reporting person,       the collection of information contained
see instruction 4(b)(v).                in this form are not required to respond
                                        unless the form displays a currently 
                                        valid OMB control number.

                                                                 

<PAGE>
 
                                                                         (Over)
                                                                SEC 2270 (3/91)

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++

FORM 5 (continued)   

<TABLE> 
<CAPTION> 

                          Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned 
                                  (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security  2. Conversion    3. Transaction  4. Transaction    5. Number of Derivative      6. Date Exercisable
  (Instr. 3)                        or Exercise      Date            Code              Securities Acquired (A)      and Expiration 
                                    Price of        (Month Day       (Instr. 8)        or Disposed of (D)           Date
                                    Derivative       Year)                            (Instr. 3, 4, and 5)         (Month, Day
                                    Security                                                                        Year)
                                                                                    --------------------------   -------------------
                                                                                        (A)        (D)            Date    Expiration
                                                                                                                  Exer-   Date 
                                                                                                                  cisable  
- -------------------------------  --------------   --------------  --------  -----   --------------- ----------   -------------------
<S>                              <C>              <C>             <C>       <C>     <C>             <C>          <C>      <C> 
Option to Buy                             $5.75         7/24/98       A                      20,000              7/24/99+ 7/24/2008 
- -------------------------------  --------------   --------------  --------  -----   --------------- ----------   -------------------

- -------------------------------  --------------   --------------  --------  -----   --------------- ----------   -------------------

- -------------------------------  --------------   --------------  --------  -----   --------------- ----------   -------------------

- -------------------------------  --------------   --------------  --------  -----   --------------- ----------   -------------------

- -------------------------------  --------------   --------------  --------  -----   --------------- ----------   -------------------

- -------------------------------  --------------   --------------  --------  -----   --------------- ----------   -------------------

- -------------------------------  --------------   --------------  --------  -----   --------------- ----------   -------------------

- -------------------------------  --------------   --------------  --------  -----   --------------- ----------   -------------------
</TABLE> 


<TABLE> 
<CAPTION> 
7. Title and Amount of    8. Price of Derivative  9. Number of Derivative     10. Ownership of             11. Nature of the 
   Underlying Securities     Security (Instr. 5)     Securities Beneficially      Derivative Security:         Indirect Beneficial
  (Instr. 3 AND 4)                                   Owned at End of Year         Direct (D) or                Ownership (Instr. 4) 
                                                     Instr. 4)                    Indirect (I) (Instr. 4)      
- ------------------------  
  Title       Amount or
              Number of
              Shares
- ------------------------  ----------------------  --------------------------  ---------------------------  ------------------------ 
<S>                       <C>                     <C>                         <C>                          <C> 
Common Stock      20,000                       0                     172,500                             
- ------------------------  ----------------------  --------------------------  ---------------------------  ------------------------ 

- ------------------------  ----------------------  --------------------------  ---------------------------  ------------------------ 

- ------------------------  ----------------------  --------------------------  ---------------------------  ------------------------ 

- ------------------------  ----------------------  --------------------------  ---------------------------  ------------------------ 

- ------------------------  ----------------------  --------------------------  ---------------------------  ------------------------ 

- ------------------------  ----------------------  --------------------------  ---------------------------  ------------------------ 

- ------------------------  ----------------------  --------------------------  ---------------------------  ------------------------ 

- ------------------------  ----------------------  --------------------------  ---------------------------  ------------------------ 
</TABLE> 

Explanation of Responses:

+Options exercisable at a rate of 25% of such option on each of the first four 
 anniversary dates of the date of the grant, which was July 24, 1998.

                                      /s/Thomas J. Bigger         2/11/99

                                  ------------------------    ----------------
                                  **Signature of Reporting     Date   

** Intentional misstatements or omissions of facts constitute Federal Criminal 
   Violations
   See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed.
     If space provided is insufficient, see Instructions 6 for procedure.

Potential persons who are to respond to the collection of information contained 
in this form are not required to respond unless the form displays a currently 
valid OMB number.






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