GENTA INCORPORATED /DE/
SC 13D, 1997-02-24
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934


                               Genta Incorporated
                                (Name of Issuer)


                     Common Stock, par value $.001 per share
                         (Title of Class of Securities)

                                  372 45 M 108
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                                 with a copy to:

David R. Walner, Esq.                                       Monica C. Lord, Esq.
Paramount Capital Asset                                     Kramer, Levin,
   Management, Inc.                                           Naftalis & Frankel
787 Seventh Avenue                                          919 Third Avenue
New York, NY 10019                                          New York, NY  10022
(212) 554-4372                                             (212) 715-9100

       (Name, Address and Telephone Number of Person Authorized to Receive
                           Notices and Communications)


                                February 13, 1997
             (Date of Event which Requires Filing of this Statement)



If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following: |_|



                               Page 1 of 99 Pages


<PAGE>

                                       
CUSIP No. 375 45 M 108                 13D                   Page 2 of 99 Pages
- --------------------------------------------------------------------------------
1) NAMES OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

   Paramount Capital Asset Management, Inc.               
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    |_|

                                                          (b)    |_|
- --------------------------------------------------------------------------------
3)       SEC USE ONLY


- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*

         OO (see Item 3)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          
                                                                 |_|
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION

         Delaware         
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          40,915,000
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER

                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER

                        40,915,000
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 

         40,915,000
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                  
                                                                 |_|
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         51.1%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON

         CO
- --------------------------------------------------------------------------------
<PAGE>
                                       
CUSIP No. 375 45 M 108                 13D                   Page 3 of 99 Pages
- --------------------------------------------------------------------------------
1) NAMES OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

   Aries Domestic Fund, L.P.               
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    |_|

                                                          (b)    |_|
- --------------------------------------------------------------------------------
3)       SEC USE ONLY


- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*

         OO (see Item 3)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          
                                                                 |_|
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION

         Delaware         
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          14,274,500
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER

                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER

                        14,274,500
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 

         14,274,500
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                  
                                                                 |_|
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         17.8%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON

         PN
- --------------------------------------------------------------------------------


<PAGE>

CUSIP No. 375 45 M 108                 13D                   Page 4 of 99 Pages
- --------------------------------------------------------------------------------
1) NAMES OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

   The Aries Trust
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    |_|

                                                          (b)    |_|
- --------------------------------------------------------------------------------
3)       SEC USE ONLY


- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*

         OO (see Item 3)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          
                                                                 |_|
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION

         Cayman Islands
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          24,640,500
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER

                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER

                        24,640,500
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 

         24,640,500
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                  
                                                                 |_|
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         33.3%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON

         OO (see Item 2)
- --------------------------------------------------------------------------------


<PAGE>


                                       
CUSIP No. 375 45 M 108                 13D                   Page 5 of 99 Pages
- --------------------------------------------------------------------------------
1) NAMES OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

   Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    |_|

                                                          (b)    |_|
- --------------------------------------------------------------------------------
3)       SEC USE ONLY


- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*

         OO (see Item 3)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          
                                                                 |_|
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION

         United States
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          40,915,000
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER

                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER

                        40,915,000
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 

         40,915,000
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES                                                  
                                                                 |_|
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         51.1%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON

         IN
- --------------------------------------------------------------------------------


<PAGE>

Item 1.   Security and Issuer.

     (a)  This Statement on Schedule 13D (the "Statement") relates to the Common
          Stock, $.001 par value (the "Common Stock") of Genta  Incorporated,  a
          Delaware  corporation (the "Issuer").  The principal executive offices
          of the Issuer are located at 3550 General  Atomics  Court,  San Diego,
          California 92121.

Item 2.   Identity and Background.

     Names of Persons Filing:

     (a)  This  statement  is  filed  on  behalf  of  Paramount   Capital  Asset
          Management,  Inc.  ("Paramount  Capital"),  Aries Domestic Fund,  L.P.
          ("Aries Domestic"), The Aries Trust ("Aries Trust") and Dr. Lindsay A.
          Rosenwald (collectively,  "Reporting Persons"). See attached Exhibit A
          which is a copy of their  agreement in writing to file this  statement
          jointly on behalf of each of them.

     (b)  The business  address of  Paramount  Capital,  Aries  Domestic and Dr.
          Rosenwald  is 787  Seventh  Avenue,  44th Floor,  New York,  New York,
          10019.  The  business  address  for  Aries  Trust  is c/o  MeesPierson
          (Cayman) Limited, P.O. Box 2003, British American Centre, Phase 3, Dr.
          Roy's Drive, George Town, Grand Cayman.

     (c)  Dr.  Rosenwald  is an  investment  banker,  venture  capitalist,  fund
          manager and sole shareholder of Paramount  Capital/1/,  a Subchapter S
          corporation  incorporated in the State of Delaware.  Paramount Capital
          is the General  Partner of Aries  Domestic/2/,  a limited  partnership
          incorporated in Delaware.  Paramount Capital is the Investment Manager
          to Aries Trust/3/, a Cayman Islands Trust.

     (d)  Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Trust and
          their respective  officers,  directors,  general partners,  investment
          managers,  and trustees  have not,  during the five years prior to the
          date  hereof,  been  convicted  in a  criminal  proceeding  (excluding
          traffic violations or similar misdemeanors).

     (e)  Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Trust and
          their respective  officers,  directors,  general partners,  investment
          managers,  and trustees have not been,  during the five years prior to
          the date  hereof,  parties  to a civil  proceeding  of a  judicial  or
          administrative  body of competent  jurisdiction,  as a result of which
          such  person was or is subject to a  judgment,  decree or final  order
          enjoining future violations of, or prohibiting or mandating activities
          subject to, Federal or State  securities laws or finding any violation
          with respect to such laws.

     (f)  Dr. Rosenwald is a citizen of the United States.

- --------
                  
     /1/  Please see attached  Exhibit B indicating  the executive  officers and
          directors of Paramount Capital and providing information called for by
          Items 2-6 of this statement as to said officers and directors. Exhibit
          B is herein incorporated by reference. 

     /2/  Please see attached  Exhibit C indicating the general partner of Aries
          Domestic and the general  partner's  executive  officers and directors
          and providing information called for by Items 2-6 of this statement as
          to said general partners, officers and directors.  Exhibit C is herein
          incorporated by reference.  

     /3/  Please see attached Exhibit D indicating the investment manager of the
          Aries  Trust  and the  investment  manager's  executive  officers  and
          directors  and providing  information  called for by Items 2-6 of this
          statement as to said  investment  manager and officers and  directors.
          Exhibit D is herein incorporated by reference.


                               Page 6 of 99 Pages


<PAGE>

Item 3.   Source and Amount of Funds or Other Consideration.

          On February 13, 1997,  pursuant to Senior Secured  Convertible  Bridge
          Notes (the  "Notes"),  Aries  Domestic  used its general funds to lend
          $1,050,000 to the Issuer and the Aries Trust used its general funds to
          lend $1,950,000 to the Issuer (collectively,  the "Loans").  The Notes
          are convertible  upon certain events into a number of shares of Series
          D  Convertible  Preferred  Stock at a  conversion  rate  equal to five
          dollars ($5.00) per share subject to adjustment upon the occurrence of
          certain events.  Section 3 of the Note and Warrant Purchase  Agreement
          provides  that if a Note is not paid in full at maturity  and upon the
          occurrence  of an Event of  Default  referred  to in  Section 7 of the
          Notes, in addition to other available remedies,  the lesser of (i) the
          then-outstanding  principal  amount  of such  Note or (ii)  10% of the
          original principal amount of such Note is convertible into a number of
          shares of Common Stock equal to the amount converted divided by $.001.
          The shares of Series D  Convertible  Preferred  Stock are  convertible
          into  20,000,000  shares of Common Stock of the Issuer at a conversion
          rate equal to $.30 per share subject to adjustment upon the occurrence
          of certain events. Additionally,  on February 13, 1997, Aries Domestic
          acquired  (a) Class A Bridge  Warrants  for the  purchase of 2,730,000
          shares of Common  Stock of the Issuer at an  exercise  price  equal to
          $.001 per share and (b) Class B Bridge  Warrants  for the  purchase of
          4,270,000  shares of Common  Stock of the Issuer at an exercise  price
          equal to $.55 per share.  The Aries Trust  acquired (a) Class A Bridge
          Warrants for the  purchase of 5,070,000  shares of Common Stock of the
          Issuer at an  exercise  price equal to $.001 per share and (b) Class B
          Bridge  Warrants for the purchase of 7,930,000  shares of Common Stock
          of the  Issuer  at an  exercise  price  equal  to $.55 per  share.  In
          addition to the  foregoing,  prior to February 13, 1997 the  Reporting
          Persons  acquired  a total of  915,000  shares  of Common  Stock  (the
          "Purchased Common Stock") in open market transactions. See Item 5. The
          Reporting  Persons  disclaim  beneficial  ownership  of all the Common
          Stock except the Purchased Common Stock.

Item 4.   Purpose of Transaction.

          The  Reporting  Persons  acquired  securities  of  the  Issuer  as  an
          investment  in the  Issuer.  While  the  Reporting  Persons  have  had
          discussions  with management and others  concerning the operations and
          capital  structure  of the  Issuer  and  changes  to  management,  the
          Reporting  Persons have not formulated any definitive  plans regarding
          the operations and business of the Issuer. Pursuant to Section 7.20 of
          the Note and Warrant Purchase  Agreement,  the Reporting  Persons have
          the  right to  appoint  a  majority  of the  members  of the  Board of
          Directors  of the  Issuer;  provided,  however,  that in the event the
          Issuer has not obtained Future  Financings (as defined in the Note and
          Warrant  Purchase  Agreement) in excess of $3,500,000 on or before the
          date which is six months  after the Bridge  Closing  Date  referred to
          therein,  then the Reporting  Persons shall have the contractual right
          to  appoint  only  two  directors  or  observers  and,  if  additional
          directors  have been  appointed,  they are  required  to  resign.  The
          Reporting Persons have to date not exercised such right. In connection
          with  the  Loan  and  the  related  transactions  (collectively,   the
          "Transactions"),  the Issuer amended its Shareholder  Rights Agreement
          (the  "Plan")  dated as of October 1, 1993,  to provide  that the Plan
          would not be applicable to the Reporting Persons and the Transactions.
          The Reporting  Persons may from time to time  acquire,  or dispose of,
          Common Stock and/or  other  securities  of the Issuer if and when they
          deem  it  appropriate.  The  Reporting  Persons  may  formulate  other
          purposes, plans or proposals relating to any of such securities of the
          Issuer to the extent deemed  advisable in light of market  conditions,
          investment  policies  and other  factors.  On  February  5, 1997,  two
          holders of Series A Convertible  Preferred  Stock filed an action (the
          "Action") in the Delaware Court of Chancery (the "Court")  against the
          Issuer, the members of the Issuer's Board of Directors, as well as the
          Aries Trust and Aries  Domestic,  challenging the  Transactions.  In a
          conference with counsel for the parties on February 7, 1997, the Court
          denied a request by the plaintiffs to preclude certain elements of the
          Transactions.  The  defendants in the Action have filed answers to the
          complaint  which  deny the  material  allegations  and  raise  various
          affirmative defenses.  Aries Domestic and the Aries Trust believe that
          they have meritorious  defenses to the claims asserted against them in
          the Action, and they intend to vigorously contest the claims.


                               Page 7 of 99 Pages


<PAGE>

          Except as  indicated  in this  Schedule  13D,  the  Reporting  Persons
          currently have no plans or proposals that relate to or would result in
          any of the matters  described in subparagraphs (a) through (j) of Item
          4 of Schedule 13D.

Item 5.   Interest in Securities of the Issuer.

          (a)  As of February 13, 1997,  Dr.  Rosenwald and  Paramount  Capital,
               through  acquisition  of the shares by the Aries  Trust and Aries
               Domestic,  may be deemed to beneficially own 40,915,000 shares or
               51.1% of the  Issuer's  securities,  and Aries  Domestic  and the
               Aries  Trust  may be  deemed to  beneficially  own the  following
               number of shares of Common Stock:


               Aries Domestic                                14,274,500
               Aries Trust                                         26,640,500

               The Reporting  Persons disclaim  beneficial  ownership of all the
               Common Stock except the Purchased Common Stock.

               (b)  Dr. Rosenwald and Paramount  Capital share the power to vote
                    or  to  direct  the  vote,  to  dispose  or  to  direct  the
                    disposition  of those shares owned by each of Aries Domestic
                    and Aries Trust.

               (c)  Other than the  purchase of the Notes and the receipt of the
                    Class A Warrants  and the Class B  Warrants,  the  Reporting
                    Persons have not engaged in any  transactions  in the Common
                    Stock of the Issuer in the past 60 days. See Item 3.

               (d)  & (e) Not applicable.



Item 6.        Contracts,  Arrangements,  Understandings  or Relationships  with
               respect to Securities of the Issuer

               Paramount  Capital is the  investment  manager of the Aries Trust
               and the General  Partner of Aries Domestic and in such capacities
               has the authority to make certain investment  decisions on behalf
               of such entities,  including decisions relating to the securities
               of the  Issuer.  In  connection  with its  investment  management
               duties,  Paramount  Capital receives certain  management fees and
               performance  allocations from the Aries Trust and Aries Domestic.
               Dr.  Rosenwald  is the sole  shareholder  of  Paramount  Capital.
               Additionally,  on January 28,  1997,  the Issuer  entered  into a
               Letter of Intent with Paramount  Capital,  Inc. pursuant to which
               it is  contemplated  that  Paramount  Capital,  Inc.  will act as
               financial  advisor and investment banker for the Issuer in future
               capital raising and other strategic  transactions for the Issuer.
               Dr. Rosenwald is the sole shareholder of Paramount Capital,  Inc.
               Except  as  indicated  in this  13D  and  exhibits,  there  is no
               contract, arrangement,  understanding or relationship between the
               Reporting  Persons  and any other  person,  with  respect  to any
               securities of the Issuer.


Item 7.        Material to be Filed as Exhibits:

Exhibit A:     Agreement  of Joint  Filing of Schedule  13D dated as of February
               13, 1997.

Exhibit B:     List of executive officers and directors of Paramount Capital and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

Exhibit C:     List of executive  officers and  directors of Aries  Domestic and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

Exhibit D:     List of  executive  officers  and  directors  of Aries  Trust and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.


                               Page 8 of 99 Pages


<PAGE>

Exhibit E:     Note and Warrant Purchase Agreement dated as of January 28, 1997.

Exhibit F:     Senior  Convertible  Bridge Note for  $1,050,000  issued to Aries
               Domestic dated January 28, 1997.

Exhibit G:     Senior Secured  Convertible  Bridge Note for $1,950,000 issued to
               Aries Trust dated January 28, 1997.

Exhibit H:     Class A Bridge  Warrant for the Purchase of  2,730,000  shares of
               Common Stock issued to Aries Domestic dated January 28, 1997.

Exhibit I:     Class A Bridge  Warrant for the Purchase of  5,070,000  shares of
               Common Stock issued to Aries Trust dated January 28, 1997.

Exhibit J:     Class B Bridge  Warrant for the Purchase of  4,270,000  shares of
               Common Stock issued to Aries Domestic dated January 28, 1997.

Exhibit K:     Class B Bridge  Warrant for the Purchase of  7,930,000  shares of
               Common Stock issued to Aries Trust dated January 28, 1997.

Exhibit L:     Letter of Intent dated January 28, 1997.


                               Page 9 of 99 Pages


<PAGE>

                                   SIGNATURES

         After  reasonable  inquiry and to the best  knowledge and belief of the
undersigned,  the  undersigned  certify that the  information  set forth in this
statement is true,  complete and correct.  

                                    PARAMOUNT  CAPITAL ASSET  MANAGEMENT, INC.

Dated: February 24, 1997
       New York, NY                 By: /s/Lindsay A. Rosenwald, M.D.
                                        ---------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President

                                    ARIES DOMESTIC FUND, L.P.
                                    By: Paramount Capital Asset Management, Inc.
                                        General Partner

Dated: February 24, 1997
       New York, NY                 By: /s/Lindsay A. Rosenwald, M.D.
                                        ---------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President



                                    THE ARIES TRUST
                                    By: Paramount Capital Asset Management, Inc.
                                        Investment Manager

Dated: February 24, 1997
       New York, NY                 By: /s/Lindsay A. Rosenwald, M.D.
                                        ---------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President


Dated: February 24, 1997
       New York, NY                 By: /s/Lindsay A. Rosenwald, M.D.
                                        ---------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        


                              Page 10 of 99 Pages


<PAGE>

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D


         The  undersigned  hereby  agrees  to  jointly  prepare  and  file  with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting   each  of  the   undersigned's   ownership  of  securities  of  Genta
Incorporated  and hereby  affirm that such Schedule 13D is being filed on behalf
of each of the undersigned.


                                    PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated: February 13, 1997
       New York, NY                 By: /s/Lindsay A. Rosenwald, M.D.
                                        ---------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President



                                    ARIES DOMESTIC FUND, L.P.
                                    By Paramount Capital Asset Management, Inc.
                                    General Partner

Dated: February 13, 1997
       New York, NY                 By: /s/Lindsay A. Rosenwald, M.D.
                                        ---------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President


                                    THE ARIES TRUST
                                    By Paramount Capital Asset Management, Inc.
                                    Investment Manager

Dated: February 13, 1997            By: /s/Lindsay A. Rosenwald, M.D.
       New York, NY                     ---------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President
                       
Dated: February 13, 1997            By: /s/Lindsay A. Rosenwald, M.D.
       New York, NY                     ---------------------------------
                                        Lindsay A. Rosenwald, M.D.
                                        President
                       
           
                              Page 11 of 99 Pages


<PAGE>

                                    EXHIBIT B

         The name and principal occupation or employment, which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  44th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                               PRINCIPAL OCCUPATION
         NAME                                      OR EMPLOYMENT

Lindsay A. Rosenwald, M.D.            Chairman of the Board, President of
                                      Paramount Capital Asset Management, Inc.,
                                      Paramount Capital Investments LLC and
                                      Paramount Capital, Inc.

Peter Morgan Kash                     Director of Paramount Capital Asset
                                      Management, Inc., Inc., Senior Managing
                                      Director, Paramount Capital, Inc.

Dr. Yuichi Iwaki                      Director of Paramount Capital Asset
                                      Management, Inc., Inc., Professor, Univer-
                                      sity of Southern California School of Med-
                                      icine


Item 2.

         During  the five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                              Page 12 of 99 Pages


<PAGE>

                                    EXHIBIT C

         The name and principal  occupation or employment of the General Partner
of Aries Domestic, which is located at 787 Seventh Avenue, 44th Floor, New York,
New York, 10019, is as follows:

                                                   PRINCIPAL OCCUPATION
         NAME                                         OR EMPLOYMENT

Paramount Capital Asset Management, Inc.     General Partner; Investment Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years prior to the date  hereof,  the above  person (to
the best of Aries  Domestic's  knowledge)  has not been  convicted in a criminal
proceeding  (excluding traffic violations or similar misdemeanors) and was not a
party to a civil  proceeding of a judicial or  administrative  body of competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                              Page 13 of 99 Pages


<PAGE>

                                    EXHIBIT D

         The name and principal  occupation or employment,  which in the case of
Paramount Capital Asset Management,  Inc. is located at 787 Seventh Avenue, 44th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                     PRINCIPAL OCCUPATION
         NAME                                             OR EMPLOYMENT

Paramount Capital Asset Management, Inc.             Investment Manager

MeesPierson (Cayman) Limited                         Trustee
P.O. Box 2003
British American Centre
Phase 3, Dr. Roy's Drive
George Town, Grand Cayman

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years  prior to the date  hereof,  neither of the above
persons  (to the best of Aries  Trust's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                              Page 14 of 99 Pages

<PAGE>
                                    EXHIBIT E

                       NOTE AND WARRANT PURCHASE AGREEMENT


         PURCHASE  AGREEMENT (this "Agreement") dated as of January 28, 1997, by
and among GENTA INCORPORATED., a Delaware corporation (the "Company"), THE ARIES
FUND, A CAYMAN ISLAND TRUST (the "Trust"),  and THE ARIES DOMESTIC FUND, L.P., a
Delaware limited partnership (the  "Partnership")  (collectively with the Trust,
the "Purchasers").

         The Company  desires to issue and sell to  Purchasers,  and  Purchasers
desire to purchase from the Company,  $3,000,000 aggregate face amount of Senior
Secured Bridge Notes (the "Bridge Notes") in the form attached hereto as Exhibit
A,  7,800,000  Class A Bridge  Warrants (the "Class A Warrants") to purchase one
share of the Common  Stock,  par value  $.001 per  share,  of the  Company  (the
"Common Stock") in the form attached as Exhibit B hereto, and 12,200,000 Class B
Bridge  Warrants to purchase  one share of the Common  Stock of the Company (the
"Class B Warrants",  and collectively with the Class A Warrants, the "Warrants")
in the form  attached  hereto as  Exhibit  C, upon and  subject to the terms and
conditions hereinafter set forth. Accordingly,  in consideration of the premises
and the mutual agreements  contained  herein,  Purchasers and the Company hereby
agree as follows:

         1. Purchase of Company Securities.

         1.1.  Purchase and Sale of the Notes and the  Warrants.  Subject to the
terms and  conditions  set forth herein,  the Company hereby agrees to issue and
sell to Purchasers,  and Purchasers,  severally and not jointly, hereby agree to
purchase from the Company,  the Bridge Notes and the Warrants (allocated amongst
the  Purchasers as set forth on Exhibit D hereof),  at the Closing (as such term
is defined in Section 2.1 hereof).  The aggregate  purchase price for the Bridge
Notes and the Warrants sold pursuant to this Agreement (including any additional
shares of Common Stock  issuable  pursuant to Section  8.6) shall be  $3,000,000
(the "Purchase Price") (allocated amongst the Purchasers as set forth on Exhibit
D hereof).  "Operative Documents" as used herein shall mean this Agreement,  the
Bridge  Notes,  the Warrants,  the Security  Agreement  and the  Certificate  of
Designations for the Series D Preferred Stock.

         2. Closing.

         2.1. Closing.  The closing of the purchase and sale of the Bridge Notes
and the Warrants  will take place at the offices of Paramount  Capital,  Inc. at
787 Seventh Avenue, New York, New York, 10019. Such closing (the "Closing") will
take place at 10:00 A.M.,  local time,  on January 30, 1997;  provided  that the
Closing  may  take  place at such  other  time,  place  or later  date as may be
mutually agreed upon by the Company and  Purchasers.  The date of the Closing is
referred to herein as the  "Closing  Date." At the  Closing,  the  Company  will
deliver to Purchasers  the Bridge Notes and the Warrants  purchased as set forth
in Section 1 hereof,  against  payment of the Purchase Price by  Purchasers,  by
wire transfer payable to the Company. The Bridge Notes and the Warrants shall be
registered in  Purchasers'  name or the name of the  nominee(s) of Purchasers in
such   denominations  as  Purchasers  shall  request  pursuant  to  instructions
delivered to the Company not less than two days prior to the Closing Date.

         3.  Conditions to the  Obligations  of  Purchasers at the Closing.  The
obligation  of  Purchasers  to  purchase  and pay for the  Bridge  Notes and the
Warrants  to be  purchased  by  Purchasers  at the  Closing  is  subject  to the
satisfaction on or prior to the Closing Date of the following conditions,  which
may only be waived by written consent of Purchasers:

         3.1. Opinion of Counsel to the Company.  Purchasers shall have received
from Pillsbury  Madison & Sutro LLP, counsel for the Company,  its opinion dated
the Closing Date in the form of Exhibit D hereto.

         3.2.  Representations  and Warranties.  All of the  representations and
warranties of the Company  contained in this Agreement shall be true and correct
at and as of the  Closing  Date,  except to the extent of changes  caused by the
transactions contemplated hereby.


                                  Page 15 of 99 Pages


<PAGE>

         3.3.  Performance of Covenants.  All of the covenants and agreements of
the Company contained in this Agreement and required to be performed on or prior
to the Closing Date shall have been  performed in a manner  satisfactory  in all
respects to Purchasers.

         3.4. Legal Action. No injunction,  order, investigation,  claim, action
or  proceeding  before  any  court or  governmental  body  shall be  pending  or
threatened  wherein an  unfavorable  judgment,  decree or order would  restrain,
impair or prevent the carrying out of this Agreement or any of the  transactions
contemplated  hereby,  declare  unlawful the  transactions  contemplated by this
Agreement or cause any such transaction to be rescinded.

         3.5.  Consents.  The Company shall have obtained in writing or made all
consents, waivers,  approvals,  orders, permits, licenses and authorizations of,
and registrations,  declarations,  notices to and filings and applications with,
any  governmental  authority or any other person or entity  (including,  without
limitation,  securityholders  and  creditors  of  the  Company)  required  to be
obtained  or made in order to enable the  Company to observe and comply with all
its  obligations  under  this  Agreement  and  to  consummate  the  transactions
contemplated hereby.

         3.6. Closing Documents.  The Company shall have delivered to Purchasers
the following:

         (a) a certificate  executed by the President or Chief Executive Officer
of the Company dated the Closing Date stating that the  conditions  set forth in
Sections 3.2 through 3.5 have been satisfied;

         (b) an incumbency  certificate  dated the Closing Date for the officers
of the Company  executing this Agreement,  the Bridge Notes and the Warrants and
any other  documents or instruments  delivered in connection with this Agreement
at the Closing;

         (c) a  certificate  of the  Secretary  or  Assistant  Secretary  of the
Company,  dated the Closing Date, as to the continued and valid existence of the
Company,  certifying  the  attached  copy of the  By-laws  of the  Company,  the
authorization of the execution,  delivery and performance of this Agreement, and
the resolutions adopted by the Board of Directors of the Company authorizing the
actions to be taken by the Company under this Agreement;

         (d) a  certificate  of the Secretary of State of the State of Delaware,
dated a recent date,  to the effect that the Company is in good  standing in the
State of  Delaware  and that all  annual  reports,  if any,  have been  filed as
required and that all taxes and fees have been paid in connection therewith;

         (e) a certified copy of the Certificate of Incorporation of the Company
as filed with the Secretary of State of the State of Delaware and any amendments
thereto; and

         (f) such  certificates,  other  documents and instruments as Purchasers
and their counsel may reasonably  request in connection with, and to effect, the
transactions contemplated by this Agreement.

         3.7.  Proceedings.  All corporate and other  proceedings taken or to be
taken in connection with the transactions  contemplated hereby to be consummated
at the Closing and all documents  incident thereto shall be satisfactory in form
and substance to Purchasers.

         3.8. Due  Diligence.  Prior to the Closing Date,  Purchasers  and their
counsel shall have  completed  their due  diligence  and business  review of the
Company,  its  business,  assets,  liabilities,  corporate  and legal status and
intellectual property,  including patents, licenses and technical processes, all
of which shall be satisfactory in form and substance to each Purchaser and their
counsel in each Purchaser's sole discretion.

         3.9. Closing Financial Statements;  Absence of Changes. (a) The Company
shall have provided to Purchasers (i) the unaudited balance sheet of the Company
as of September 30, 1996, and the related unaudited  statement of operations for
the  three-month  (and  nine-month)  periods then ended,  as well as the related
unaudited  statements of  stockholders'  equity (deficit) and cash flows for the
nine-month  period  then ended,  accompanied  by the  unqualified  certification
thereon of the Chief Financial Officer or Vice President--Finance of the Company
(together with any notes thereto, the "September 30


                              Page 16 of 99 Pages

<PAGE>

Financial  Statements")  and  (ii)  a  "bring-down"  certificate  of  the  Chief
Executive  Officer  of the  Company  and the  Chief  Financial  Officer  or Vice
President--Finance  of the Company with respect to the financial position of the
Company as of the Closing Date and as to results for the period from the date of
the September 30 Financial Statements to the Closing Date, in form and substance
satisfactory to Purchaser and its counsel.

         (b)  Except  as  set  forth  on the  schedules  hereto  of the  Company
delivered to Purchaser as of the date hereof,  there shall have been no material
adverse  change in the  financial  condition,  operating  results,  employee  or
customer  relations or prospects  of, or otherwise  with respect to, the Company
from the date of the September 30 Financial Statements to the Closing Date.

         3.10.  Security  Agreement.  The  Company  shall  have  entered  into a
security agreement (the "Security  Agreement") with Paramount Capital,  Inc., as
collateral  agent,  reasonably  acceptable  to the  Partnership  and  the  Trust
pursuant  to which the Company  shall  grant the  holders of the Bridge  Notes a
first  lien  security  interest  in all of the assets of the  Company  which the
Company is not otherwise  restricted from granting such a security  interest and
the  Company  shall have taken all steps  necessary  to  perfect  such  security
interest.

         3.11. Schedules.  The Company shall have provided to the Purchasers all
schedules  required  pursuant  to  this  Agreement,  which  schedules  shall  be
satisfactory to Purchasers in their sole discretion.

         4.  Conditions to the  Obligations  of the Company at the Closing.  The
obligation  of the  Company  to issue  and sell the Notes  and the  Warrants  to
Purchasers  at the  Closing is subject  to the  satisfaction  on or prior to the
Closing  Date of the  following  conditions,  any of which  may be waived by the
Company:

         4.1. Representations and Warranties. The representations and warranties
of Purchasers contained in this Agreement shall be true and correct at and as of
the Closing Date.

         4.2. Legal Action. No injunction,  order, investigation,  claim, action
or  proceeding  before  any  court or  governmental  body  shall be  pending  or
threatened  wherein an  unfavorable  judgment,  decree or order would  restrain,
impair or prevent the carrying out of this Agreement or any of the  transactions
contemplated  hereby,  declare  unlawful the  transactions  contemplated by this
Agreement or cause any such transaction to be rescinded.

         5.  Representations  and Warranties of the Company.  The Company hereby
represents and warrants to Purchasers as follows:

         5.1. Organization. The Company is a corporation duly organized, validly
existing  and in good  standing  under  the laws of the State of  Delaware.  The
Company has all requisite corporate power and authority, and holds all licenses,
permits  and  other  required  authorizations  from  governmental   authorities,
necessary to conduct its business as it is now being conducted or proposed to be
conducted  and to own or lease the  properties  and  assets it now owns or holds
under  lease  (except  that the  Company may in the future be required to obtain
certain  approvals of the U.S. Food and Drug  Administration  in connection with
its  business as proposed to be  conducted).  The Company is duly  qualified  or
licensed  and in good  standing as a foreign  corporation  in each  jurisdiction
wherein  the  character  of its  properties  or  the  nature  of the  activities
conducted by it makes such qualification or licensing necessary.

         5.2.  Charter  Documents.  The  Company  has  heretofore  delivered  to
Purchasers  true,  correct and complete  copies of the Company's  Certificate of
Incorporation and By-Laws as in full force and effect on the date hereof.

         5.3.  Capitalization.  As of the date hereof, the Company's  authorized
capitalization  consists  of:  150,000,000  shares  of  Common  Stock,  of which
39,991,626  shares are presently  issued and  outstanding;  5,000,000  shares of
preferred  stock,  par value  $.001  per  share,  of which  600,000  shares  are
designated as Series A Convertible  Preferred Stock (528,100 of which are issued
and  outstanding),  3,000 of  which  are  designated  as  Series  B  Convertible
Preferred Stock (none of which are issued and outstanding) and 7100 of which are
designated as Series C Convertible Preferred Stock (1424 of which are issued and
outstanding)  and  20,000  of which  are  designated  as  Series  F  Convertible
Preferred  Stock  (none of which are issued  and  outstanding);  and  18,423,610
shares of Common Stock are


                              Page 17 of 99 Pages


<PAGE>

reserved for issuance upon the  conversion or exercise of presently  outstanding
convertible  securities,  options,  warrants or other rights to purchase  Common
Stock. All outstanding  securities of the Company are validly issued, fully paid
and  nonassessable.  No stockholder of the Company is entitled to any preemptive
rights with  respect to the purchase or sale of any  securities  by the Company.
Except as has been set forth in Schedule  5.3 hereto,  there are no  outstanding
options, warrants or other rights, commitments or arrangements, written or oral,
to purchase or otherwise  acquire any authorized but unissued  shares of capital
stock of the Company or any security directly or indirectly  convertible into or
exchangeable  for any  capital  stock of the  Company  or under  which  any such
option,  warrant or convertible  security may be issued in the future, and there
are no voting trusts or agreements, stockholders' agreements, pledge agreements,
buy-sell,  rights of first offer,  negotiation  or refusal or proxies or similar
arrangements relating to any securities of the Company to which the Company is a
party,  and to the best knowledge of the Company after due  investigation  there
are no such trusts,  agreement,  rights,  proxies or similar  arrangements as to
which the  Company is not a party.  Except as set forth on  Schedule  5.3 and as
contemplated  herein,  none of the  shares of  capital  stock of the  Company is
reserved for any purpose,  and the Company is neither  subject to any obligation
(contingent or otherwise), nor has any option to repurchase or otherwise acquire
or retire  any  shares of its  capital  stock.  Schedule  5.3 sets forth (i) the
number of shares of Common Stock  authorized  for issuance  under the  Company's
1991 Stock Option Plan, as amended and restated, and the Company's Non- Employee
Director  Stock  Option  Plan;  (ii) the number of shares of Common  Stock as to
which  options  under  such plan have been (a)  reserved  for  issuance  and (b)
exercised;  and (iii) the exercise prices for all outstanding options under such
plan.  Except as set forth on Schedule  5.3, no  antidilution  adjustments  with
respect to the  outstanding  securities  of the Company will be triggered by the
issuance of the securities contemplated hereby.

         5.4 Due Authorization,  Valid Issuance,  Etc.. The Notes have been duly
authorized  and, when issued in accordance  with this Agreement upon the Closing
Date, will be free and clear of all liens imposed by or through the Company. The
Warrants have been duly  authorized  and,  when issued in  accordance  with this
Agreement  upon the Closing Date,  will be validly  issued and free and clear of
all liens imposed by or through the Company.  The Common Stock issuable upon the
exercise of the Warrants have been duly  authorized  and reserved,  and upon the
exercise of the Warrants in accordance with the terms and conditions thereof and
this Agreement,  will be validly issued,  fully paid and nonassessable shares of
Common  Stock and will be free and clear of all liens  imposed by or through the
Company.  The issuance,  sale and clear delivery of the Notes,  the Warrants and
the Common Stock  issuable upon the exercise of the Warrants will not be subject
to any preemptive  right of stockholders of the Company or to any right of first
refusal or other right in favor of any person.

         5.5.  Subsidiaries.  The  Company  has no  wholly  or  partially  owned
Subsidiaries  (as  defined in Section  9.10) and does not  control,  directly or
indirectly,   any  other  corporation,   business  trust,   firm,   partnership,
association, joint venture, entity or organization. The Company does not own any
shares of stock,  partnership  interest,  joint  venture  interest  or any other
security,  equity or interest in any other corporation or other  organization or
entity.

         5.6. Authorization; No Breach. The Company has the full corporate power
and authority to execute,  deliver and enter into this  Agreement and to perform
its obligations hereunder,  and the execution,  delivery and performance of this
Agreement,  the Notes,  the  Warrants,  the Security  Agreement  and any related
financing   statement  and  the  Certificate  of  Designations   and  all  other
transactions  contemplated hereby have been duly authorized by the Company,  and
this Agreement constitutes a legal, valid and binding obligation of the Company,
enforceable in accordance with its terms except as the enforceability hereof may
be limited by (a) bankruptcy,  insolvency, moratorium and similar laws affecting
creditors'  rights  generally and (b) the availability of remedies under general
equitable  principles  and  (c) to the  extent  the  indemnification  provisions
contained  in section 8.5 hereof may be limited by  applicable  federal or state
securities laws.  Except as set forth on Schedule 5.6 hereto,  the execution and
delivery by the Company of this  Agreement,  the offering,  sale and issuance of
the Notes and the Warrants  pursuant to this Agreement,  and the performance and
fulfillment of the Company of its obligations  under this  Agreement,  the Notes
and the Warrants, do not and will not (i) conflict with or result in a breach of
the terms,  conditions or provisions  of, (ii)  constitute a default  under,  or
event which,  with notice or lapse of time or both, would constitute a breach of
or default under, (iii) result in the creation of any lien, security
interest,  adverse claim, charge or encumbrance upon the capital stock or assets
of the Company  pursuant  to, (iv) give any 


                              Page 18 of 99 Pages
<PAGE>

third party the right to  accelerate  any  obligation  under or  terminate,  (v)
result in a violation  of, (vi) result in the loss of any license,  certificate,
legal  privilege or legal right  enjoyed or possessed by the Company  under,  or
(vii) require any authorization, consent, approval, exemption or other action by
or notice to any court or  administrative  or  governmental  body pursuant to or
require the consent of any other person under,  the Certificate of Incorporation
or By-Laws of the Company or any law,  statute,  rule or regulation to which the
Company  is  subject  or by  which  any  of its  properties  are  bound,  or any
agreement, instrument, order, judgment or decree to which the Company is subject
or by which its properties are bound.

         5.7.  Financial  Statements and SEC Documents.  (a) Attached  hereto as
Schedule  5.7 are (i) the audited  financial  statements  of the Company for the
fiscal year ended  December 31, 1995,  including the balance sheet as at the end
of such fiscal  year and the related  statements  of  operations,  stockholders'
equity (deficit) and cash flows for such fiscal year, certified by Ernst & Young
L.L.P. and (ii) the September 30 Financial  Statements (the financial statements
referred to in clauses (i) and (ii) are referred to herein  collectively  as the
"Financial  Statements").  For purposes of this  Agreement,  September 30. 1996,
shall be  hereinafter  referred to as the "Balance  Sheet  Date." The  Financial
Statements  have been prepared in  accordance  with the books and records of the
Company and generally accepted accounting principles,  applied consistently with
the past practices of the Company  (except as otherwise  noted in such Financial
Statements), reflect all liabilities and obligations of the Company, as of their
respective  dates, and present fairly the financial  position of the Company and
the  results  of its  operations  as of the time and for the  periods  indicated
therein.

(b) The Company has made  available to  Purchasers  a true and complete  copy of
each report,  schedule,  registration  statement and definitive  proxy statement
filed by the Company with the Securities and Exchange  Commission  since January
1, 1993 (as such documents have since the time of their filing been amended, the
"SEC Documents")  which are all the documents (other than preliminary  material)
that  the  Company  was  required  to file  with  the  Securities  and  Exchange
Commission  since such date.  As of their  respective  dates,  the SEC Documents
complied in all respects with the requirements of the Securities Act (as defined
in Section  9.7) and/or the Exchange Act (as defined in Section 9.8) as the case
may be, and the rules and regulations of the Securities and Exchange  Commission
thereunder  applicable  to such  SEC  Documents  and  none of the SEC  Documents
contained  any untrue  statement  of a material  fact or omitted to statement of
material fact required to be stated  therein or necessary to make the statements
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading.  The  financial  statements  of the  Company  included  in  the  SEC
Documents comply as to form in all material respects with applicable  accounting
requirements  and with the published rules and regulations of the Securities and
Exchange Commission with respect thereto,  have been prepared in accordance with
generally  accepted  accounting  principles applied on a consistent basis during
the periods involved (except as may be indicated in the notes thereto or, in the
case of the unaudited  statements,  as permitted by Form 10-Q of the  Securities
and  Exchange  Commission)  and  fairly  present  (subject,  in the  case of the
unaudited  statements,  to normal,  recurring audit  adjustments)  the financial
position of the Company as at the dates thereof and the consolidated  results of
their operations and cash flows for the periods then ended.

         5.8. No Material Adverse  Changes.  Except as set forth on Schedule 5.8
hereto,  since the  Balance  Sheet  Date  there has not at any time been (a) any
material adverse change in the financial condition,  operating results, business
prospects, employee relations or customer relations of the Company, or (b) other
adverse  changes,  which in the aggregate  have been  materially  adverse to the
Company.

         5.9.  Absence of Certain  Developments.  Except as contemplated by this
Agreement,  and except as set forth in Schedule  5.9  hereto,  since the Balance
Sheet Date, the Company has not, nor will have prior to the Closing:  (a) issued
any  securities;  (b) borrowed  any amount or incurred or became  subject to any
liabilities  (absolute or contingent),  other than  liabilities  incurred in the
ordinary course of business and liabilities  under contracts entered into in the
ordinary  course of  business,  none of which are or shall be material and which
are less than $75,000;  (c)  discharged or satisfied any lien,  adverse claim or
encumbrance or paid any obligation or liability (absolute or contingent),  other
than current  liabilities paid in the ordinary course of business;  (d) declared
or  made  any  payment  or  distribution  of  cash  or  other  property  to  the
stockholders  of the Company  with  respect to the Common  Stock or purchased or
redeemed any shares of Common Stock; (e) mortgaged,  pledged or subjected to any
lien, adverse claim,  charge or any other encumbrance,  any of its properties or
assets,  except for liens for taxes not yet 


                              Page 19 of 99 Pages


<PAGE>

due and payable;  (f) sold, assigned or transferred any of its assets,  tangible
or intangible,  except in the ordinary  course of business and in an amount less
than  $75,000,  or  disclosed  to any  person,  firm or  entity  not  party to a
confidentiality   agreement  with  the  Company  any  proprietary   confidential
information;  (g)  suffered  any  extraordinary  losses or waived  any rights of
material value; (h) made any capital expenditures or commitments  therefor;  (i)
entered into any other transaction other than in the ordinary course of business
in an amount less than $75,000 or entered into any material transaction, whether
or not in the ordinary course of business; (j) made any charitable contributions
or pledges;  (k) suffered damages,  destruction or casualty loss, whether or not
covered by insurance,  affecting any of the  properties or assets of the Company
or any other  properties  or assets of the  Company  which could have a material
adverse effect on the business or operations of the Company; (l) made any change
in the nature or operations  of the business of the Company;  or (m) resolved or
entered  into  any  agreement  or  understanding  with  respect  to  any  of the
foregoing.

         5.10.  Properties.  The Company has good and marketable title to all of
the real  property and good title to all of the personal  property and assets it
purports to own, including those reflected as owned on the Company Balance Sheet
or acquired thereafter,  and a good and valid leasehold interest in all property
indicated as leased on the Company Balance Sheet,  whether such property is real
or personal, free and clear of all liens, adverse claims, charges,  encumbrances
or  restrictions of any nature  whatsoever,  except (a) such as are reflected on
the Company  Balance  Sheet or  described  in  Schedule  5.10 hereto and (b) for
receivables and charges collected in the ordinary course of business.  Except as
disclosed  in  Schedule  5.10  hereto,  the  Company  owns or  leases  all  such
properties as are necessary to its  operations as now conducted and as presently
proposed to be conducted and all such properties are, in all material  respects,
in good operating condition and repair.

         5.11. Taxes. Except as referred to in Schedule 5.11 hereto, the Company
has timely filed all federal,  state,  local and foreign tax returns and reports
required to be filed, and all taxes, fees,  assessments and governmental charges
of any nature  shown by such returns and reports to be due and payable have been
timely paid except for those amounts being contested in good faith and for which
appropriate  amounts have been reserved in accordance  with  generally  accepted
accounting  principles and are reflected on the Company Balance Sheet.  There is
no tax deficiency  which has been, or, to the knowledge of the Company might be,
asserted  against  the  Company  which would  adversely  affect the  business or
operations,  or proposed  business or operations,  of the Company.  All such tax
returns and reports were  prepared in  accordance  with the  relevant  rules and
regulations of each taxing  authority having  jurisdiction  over the Company and
are true and correct.  The Company has neither given nor been  requested to give
any waiver of any  statute of  limitations  relating  to the payment of federal,
state,  local or foreign  taxes.  The Company has not been, nor is it now being,
audited by any federal, state, local or foreign tax authorities. The Company has
made all required  deposits for taxes  applicable  to the current tax year.  The
Company is not, and has never been, a member of any  "affiliated  group"  within
the meaning of Section 1504 of the Internal Revenue Code, as in effect from time
to time.

         5.12.  Litigation.  Except as set forth on Schedule 5.12 hereto,  there
are no actions, suits, proceedings, orders, investigations or claims pending or,
to the Company's knowledge,  threatened against or affecting the Company, at law
or in equity or before or by any federal, state, municipal or other governmental
department,  commission, board, bureau, agency or instrumentality;  there are no
arbitration  proceedings  pending  under  collective  bargaining  agreements  or
otherwise;  and, to the  knowledge of the Company,  there is no basis for any of
the foregoing.

         5.13.  Compliance  with Law.  The Company has  complied in all respects
with all  applicable  statutes and  regulations  of the United States and of all
states,  municipalities  and applicable  agencies and foreign  jurisdictions  or
bodies in  respect  of the  conduct  of its  business  and  operations,  and the
failure,  if any, by the Company to have fully complied with any such statute or
regulation  does not and will not  materially  adversely  affect the business or
operations of the Company.

         5.14.  Trademarks and Patents.  Schedule 5.14 annexed hereto contains a
true,  complete and correct  list of all  trademarks,  trade names,  patents and
copyrights (and applications  therefor) if any, heretofore or presently owned or
licensed or used or required  to be used by the Company in  connection  with its
business; and, except as set forth on Schedule 5.14, each such trademark,  trade
name, patent and copyright (and 


                              Page 20 of 99 Pages


<PAGE>

application  therefor)  listed in Schedule 5.14 as being owned by the Company is
not subject to any license,  royalty arrangement,  option or dispute and is free
and  clear of all  liens.  To the best  knowledge  of the  Company,  none of the
trademarks, trade names, patents or copyrights used by the Company in connection
with its business  infringe any  trademark,  trade name,  patent or copyright of
others in the United States or in any other country,  in any way which adversely
affects or which in the future may  adversely  affect the business or operations
of the Company. Except as set forth in Schedule 5.14, no stockholder, officer or
director  of the  Company or any other  person  owns or has any  interest in any
trademark,  trade name, service mark, patent, copyright or application therefor,
or trade  secret,  licenses,  invention,  information  or  proprietary  right or
process,  if any,  used by the  Company in  connection  with its  business.  The
Company has no notice or knowledge of any  objection or claim being  asserted by
any person with respect to the ownership,  validity enforceability or use of any
such trademarks, trade names, patents and copyrights (and applications therefor)
listed  on  Schedule  5.14  or  challenging  or  questioning   the  validity  or
effectiveness of any license relating thereto. There are no unresolved conflicts
with,  or  pending  claims  of,  any other  person,  whether  in  litigation  or
otherwise,  involving the trademarks,  trade names,  patents and copyrights (and
applications therefor), and there are no liens, encumbrances, adverse claims, or
rights of any other person which would prevent the Company form  fulfilling  its
obligations  under this  Agreement.  To the best  knowledge of the Company,  the
business of the Company,  as presently conducted and as proposed to be conducted
does not and will not cause the  Company to violate any  trademark,  trade name,
patent,  copyright,  trade secret,  license or proprietary interest of any other
person or entity,  in any way which adversely affects or which in the future may
adversely affect the business or operations of the Company.  Except as disclosed
in Schedule  5.14  hereto,  the Company  possesses  all  proprietary  technology
necessary  for the  conduct  of  business  by the  Company,  both  as  presently
conducted and as presently proposed to be conducted.

         5.15.  Insurance.   Schedule  5.15  annexed  hereto  contains  a  brief
description of each insurance  policy  maintained by the Company with respect to
its  properties,  assets  and  business;  each such  policy is in full force and
effect;  and the Company is not in default with respect to its obligations under
any of such  insurance  policies.  The  insurance  coverage of the Company is in
amounts not less than is customarily  maintained by corporations  engaged in the
same or similar business and similarly situated,  including, without limitation,
insurance against loss, damage,  fire, theft,  public liability and other risks.
The  activities and operations of the Company have been conducted in a manner so
as to conform to all applicable  provisions of these insurance  policies and the
Company  has not taken or failed to take any action  which  would cause any such
insurance policy to lapse.

         5.16.  Agreements.  Except as set forth in Schedule  5.16  hereto,  the
Company is neither a party to nor bound by any agreement or commitment,  written
or oral,  which  obligates the Company to make payments to any person,  or which
obligates any person to make  payments to the Company,  in the case of each such
agreement in an amount exceeding $75,000,  or which is otherwise material to the
conduct and operation of the Company's  business or proposed  business or any of
its  properties  or assets,  including,  without  limitation,  all  shareholder,
employment, non-competition and consulting agreements and employee benefit plans
and arrangements and collective  bargaining agreements to which the Company is a
party or by which it is bound. All such agreements are legal,  valid and binding
obligations  of the  Company,  in full  force and  effect,  and  enforceable  in
accordance with their respective terms, except as the enforceability thereof may
be limited by (a) bankruptcy, insolvency, moratorium, and similar laws affecting
creditors'  rights  generally and (b) the availability of remedies under general
equitable  principles.  The Company has performed all obligations required to be
performed  by it, and is not in default,  or in receipt of any claim,  under any
such  agreement or  commitment,  and the Company has no present  expectation  or
intention of not fully performing all of such obligations,  nor does the Company
have any knowledge of any breach or  anticipated  breach by the other parties to
any such  agreement or  commitment.  The Company is not a party to any contract,
agreement,  instrument or understanding  which materially  adversely affects the
business,  properties,  operations, assets or condition (financial or otherwise)
of the Company.  Purchasers  have been  furnished  with, or the Company has made
available for the  Purchaser's  review,  a true and correct copy of each written
agreement referred to in Schedule 5.16, together with all amendments, waivers or
other changes thereto.

         5.17.  Undisclosed  Liabilities.  Except as set forth on Schedule  5.17
hereto, the Company has no obligation or liability  (whether accrued,  absolute,
contingent,  unliquidated,  or  otherwise,  whether or not known to the Company,
whether due or to become 


                              Page 21 of 99 Pages


<PAGE>

due) arising out of transactions entered into at or prior to the Closing of this
Agreement,  or any  action  or  inaction  at or  prior  to the  Closing  of this
Agreement,  or any state of facts  existing  at or prior to the  Closing of this
Agreement,  except (a) liabilities  reflected on the Company Balance Sheet;  (b)
liabilities  in an amount less than $75,000  incurred in the ordinary  course of
business  since the Balance  Sheet Date (none of which is a liability for breach
of contract, breach of warranty, torts, infringements,  claims or lawsuits); and
(c) liabilities or obligations disclosed in the schedules hereto.

         5.18. Employees;  Conflicting  Agreements.  (a) The Company shall cause
all members of management and all professional  employees of and consultants and
advisors to the Company,  including all employees and  consultants  and advisors
involved in its  research  and  development,  to be subject to  agreements  with
respect to (i)  nondisclosure  of confidential  information,  (ii) assignment of
patents, trademarks,  copyrights and proprietary rights to the Company and (iii)
disclosure to the Company of inventions.

         (b) Except as set forth on Schedule  5.18, to the best of the Company's
knowledge, no stockholder, director, officer or key employee of the Company is a
party to or bound by any agreement,  contract or  commitment,  or subject to any
restrictions in connection  with any previous or current  employment of any such
person,  which adversely  affects,  or which in the future may adversely affect,
the business or the proposed business of the Company or the rights of Purchasers
under this  Agreement  and in respect of its rights as a holder of the Notes and
the Warrants.

         5.19.  Disclosure.  Neither this  Agreement  nor any of the  schedules,
exhibits, written statements,  documents or certificates prepared or supplied by
the Company with respect to the  transactions  contemplated  hereby  contain any
untrue  statement of a material fact or omit a material  fact  necessary to make
the  statements  contained  herein or  therein  not  misleading  in light of the
circumstances  under which made.  Except as disclosed  in Schedule  5.19 hereto,
there exists no fact or circumstance which, to the knowledge of the Company upon
due  inquiry,  materially  adversely  affects,  or  which  could  reasonably  be
anticipated  to have a material  adverse  effect on, the  existing  or  expected
financial condition,  operating results,  assets,  customer relations,  employee
relations or business prospects of the Company.

         5.20.  Compliance  with the  Securities  Laws.  Except  as set forth on
Schedule  5.20 hereto,  neither the Company nor anyone  acting on its behalf has
directly or indirectly offered the Notes and the Warrants or any part thereof or
any similar  security of the Company  (or any other  securities  convertible  or
exchangeable for the Notes and the Warrants or any similar  security),  for sale
to, or solicited any offer to buy the same from,  anyone other than  Purchasers.
Assuming the accuracy and truth of each of the Purchasers'  representations  set
forth in Section 6 of this Agreement,  all securities of the Company  heretofore
sold and issued by it were sold and issued,  and the Notes and the Warrants were
offered and will be sold and issued,  in compliance with all applicable  federal
and state securities laws.

         5.21. Brokers. Except as set forth on Schedule 5.21, no finder, broker,
agent, financial person or other intermediary has acted on behalf of the Company
in  connection  with  the  offering  of  the  Notes  and  the  Warrants  or  the
consummation of this Agreement or any of the transactions contemplated hereby.

         5.22.  Transactions  with  Affiliates.  Except as set forth in Schedule
5.22, no director,  officer,  employee,  consultant or agent of the Company,  or
member of the family of any such person or any corporation,  partnership,  trust
or other  entity in which any such  person,  or any  member of the family of any
such person, has a substantial interest in or is an officer, director,  trustee,
partner or holder of more than 5% of the outstanding capital stock thereof, is a
party to any transaction with the Company, including any contract,  agreement or
other arrangement  providing for the employment of, furnishing of services by or
requiring payments to any such person or firm.

         5.23.  Environmental  Matters (a) The Company and all properties owned,
operated or leased by the Company  have  obtained  and  currently  maintain  all
environmental  permits  required for their  business and  operations  and are in
compliance  with  all  such  environmental  permits;  (ii)  there  are no  legal
proceedings  pending nor, to the best  knowledge of the Company,  threatened  to
modify or revoke any such environmental  permits;  and (iii) neither Company nor
any  property  owned,  operated or leased by the Company has received any notice
from any source that there is lacking any environmental  permit 


                              Page 22 of 99 Pages


<PAGE>

required for the current use or operation of the business of the Company, or any
property owned, operated or leased by the Company.

         (b) Except as set forth in Schedule 5.23 hereto,  (i) all real property
owned,  operated or leased by the  Company,  and, to the best  knowledge  of the
Company,  all property adjacent to such properties,  are free from contamination
by any hazardous material; and the Company is not subject to environmental costs
and  liabilities  with  respect  to  hazardous   materials,   and  no  facts  or
circumstances exist which could give rise to environmental costs and liabilities
with respect to hazardous materials.

         (c) Except as set forth in Schedule 5.23 hereto,  there is not now, nor
has there been in the past, on, in, or under any real property owned, leased, or
operated   by  the   Company,   or  by  any  of   its   predecessors   (i)   any
asbestos-containing   materials,  (ii)  any  underground  storage  tanks,  (iii)
above-ground storage tanks, (iv) impoundments,  (v) poly- chlorinated  biphenyls
or (vi) radioactive substances.

         (d) The Company  has  provided or made  available  to Buyer  drafts and
final versions of all environmental site assessments (including, but not limited
to  Phase  I and  Phase  II  reports),  risk  management  studies  and  internal
environmental  audits  that have been  conducted  by or on behalf of the Company
("Environmental  Studies"), with respect to any real property that now or in the
past  has  been  owned,  operated  or  leased  by  the  Company,  or  any of its
predecessors.

         (e) Except as set forth in Schedule  5.23  hereto,  the Company and all
properties  owned,  operated  or leased by the Company  are in  compliance  with
environmental law.

         (f) Except as set forth in Schedule  5.23  hereto,  neither the Company
nor any property  owned,  leased or operated by the Company has received or been
issued any written  request for  information,  or has been notified that it is a
potentially  responsible party under the environmental  laws with respect to any
on-site or off-site for which environmental costs and liabilities are asserted.

         6.  Representations  and  Warranties of Purchasers.  Purchasers  hereby
severally represent and warrant to the Company as follows:

         6.1.  Investment  Intent.  Each  of the  Purchasers  is an  "accredited
investor"  within the meaning of Regulation D under the Securities  Act. Each of
the  Purchasers  has  experience  in making  investments  in  development  stage
biotechnology  companies and is acquiring the Notes and the Warrants for its own
account  and not with a present  view to, or for sale in  connection  with,  any
distribution  thereof  in  violation  of the  registration  requirements  of the
Securities  Act.   Purchasers  consent  to  the  placing  of  a  legend  on  the
certificates  representing  the Notes and the  Warrants  to the effect  that the
shares of Common Stock issuable upon exercise or conversion, as the case may be,
of the  Warrants,  and the Purchase  Option have not been  registered  under the
Securities Act and may not be transferred  except in accordance  with applicable
securities laws or an exception therefrom.

         6.2.  Authorization.  Each of Purchasers has the power and authority to
execute and deliver this  Agreement  and to perform its  obligations  hereunder,
having obtained all required consents, if any, and this Agreement, when executed
and  delivered,  will  constitute a legal valid and binding  obligation  of such
Purchaser.

         6.3.  Brokers.  No finder,  broker,  agent,  financial  person or other
intermediary  has acted on behalf of Purchasers in connection  with the offering
of the Notes and the Warrants or the  consummation  of this  Agreement or any of
the transactions contemplated hereby.

         7.  Covenants of the Company.  Until such time as Purchasers  and their
affiliates beneficially own less than one percent (1%) of the Common Stock after
giving  effect to the  conversion  or exercise of all  securities of the Company
beneficially owned by Purchasers and their affiliates, the Company covenants and
agrees with Purchasers as follows:

         7.1.  Books and Accounts.  The Company  will:  (a) make and keep books,
records and accounts, which, in reasonable detail, accurately and fairly reflect
its transactions,  


                              Page 23 of 99 Pages


<PAGE>

including  without  limitation,  dispositions of its assets;  and (b) devise and
maintain  a  system  of  internal  accounting  controls  sufficient  to  provide
reasonable  assurances  that (i)  transactions  are executed in accordance  with
management's general or specific  authorization,  (ii) transactions are recorded
as necessary to permit  preparation of financial  statements in conformity  with
generally  accepted  accounting  principles and in accordance with the Company's
past  practices or any other  criteria  applicable  to such  statements,  and to
maintain  accountability for assets, (iii) access to assets is permitted only in
accordance with  management's  general or specific  authorization,  and (iv) the
recorded  accountability  for assets is  compared  with the  existing  assets at
reasonable  intervals  and  appropriate  action  is taken  with  respect  to any
differences.

         7.2.  Periodic  Reports.  (a) The Company will furnish to Purchasers as
soon as  practicable,  and in any  event  within  90 days  after the end of each
fiscal year of the Company  (commencing  with the fiscal year ended December 31,
1996, an annual  report of the Company,  including a balance sheet as at the end
of such fiscal year and statement of operations,  stockholders' equity (deficit)
and cash flows for such fiscal year,  together with the related  notes  thereto,
setting forth in each case in  comparative  form  corresponding  figures for the
preceding  fiscal  year,  all of which will be  correct  and  complete  and will
present  fairly the  financial  position  of the  Company and the results of its
operations  and  changes in its  financial  position  as of the time and for the
period  then  ended.  Such  financial  statements  shall  be  accompanied  by an
unqualified  report  (other than  qualifications  contingent  upon the Company's
ability  to  obtain  additional  financing),  in form and  substance  reasonably
satisfactory  to  Purchasers,   of  independent  public  accountants  reasonably
satisfactory  to Purchasers to the effect that such  financial  statements  have
been  prepared  in  accordance  with the books and  records of the  Company  and
generally  accepted  accounting  principles  applied on a basis  consistent with
prior years (except as otherwise  specified in such report),  and present fairly
the  financial  position of the Company  and the results of its  operations  and
changes  in their  financial  position  as of the time and for the  period  then
ended.  The Company  will use its best  efforts to conduct its  business so that
such  report  of  the  independent  public  accountants  will  not  contain  any
qualifications as to the scope of the audit, the continuance of the Company,  or
with respect to the Company's  compliance  with  generally  accepted  accounting
principles  consistently applied, except for changes in methods of accounting in
which such accountants concur.

         (b) The Company will furnish to Purchasers,  as soon as practicable and
in any event  within 45 days  after  the end of each of the first  three  fiscal
quarters of the  Company  during each  fiscal  year,  a quarterly  report of the
Company  consisting of an unaudited  balance sheet as at the end of such quarter
and an unaudited  statement of operations,  stockholders'  equity  (deficit) and
cash flows for such  quarter  and the  portion of the  fiscal  year then  ended,
setting forth in each case in  comparative  form  corresponding  figures for the
preceding  fiscal  year.  All such  reports  shall  be  certified  by the  Chief
Financial  Officer or Vice President--  Finance of the Company to be correct and
complete,  to present  fairly the  financial  position  of the  Company  and the
consolidated  results of its operations and changes in its financial position as
of the  time  and  for the  period  then  ended  and to have  been  prepared  in
accordance with generally accepted accounting principles.

         (c) The Company shall furnish to  Purchasers,  within 30 days after the
end of each calendar month, an unaudited  balance sheet of the Company as of the
end  of  such  month  and  the  related   unaudited   statement  of  operations,
stockholders'  equity (deficit) and cash flows for such month and for the fiscal
year to date,  setting  forth in each case  comparative  form the  corresponding
figures  for the budget for the current  fiscal  year,  or such other  financial
information as otherwise  agreed to by the parties  hereto.  All such statements
shall be certified by the Chief Financial Officer or Vice  President--Finance of
the  Company to the effect that such  statements  fairly  present the  financial
condition of the Company as of the dates shown and the results of its operations
for the  periods  then  ended and that such  statements  have been  prepared  in
conformity with generally accepted accounting  principles  consistently  applied
except for normal,  recurring,  year-end  audit  adjustments  and the absence of
footnotes.

         (d) Commencing  with the Company's  fiscal year  commencing  January 1,
1997, the Company shall furnish to Purchasers, as soon as practicable and in any
event not less than 60 days prior to the end of each fiscal year of the Company,
(i) an annual operating budget for the Company,  for the succeeding fiscal year,
containing  projections of profit and loss,  cash flow and ending balance sheets
for each month of such fiscal  year and (ii)


                              Page 24 of 99 Pages


<PAGE>

a business plan for the Company as specified in Section 7.19.  The Company shall
furnish to Purchasers within five days after the date the Board of Directors has
approved the annual operating budget and business plan referred to above,  which
shall be no later than 60 days after the  beginning  of each fiscal  year,  such
operating  budget  and  business  plan as  approved  by the Board of  Directors.
Promptly upon preparation  thereof,  the Company shall furnish to Purchasers any
other  operating  budgets or business plans that the Company may prepare and any
revisions or  modifications  of such  previously  furnished  budgets or business
plans.

         (e) The annual statements and quarterly  statements  furnished pursuant
to Sections 7.02(a) and (b) shall include a narrative discussion prepared by the
Company  describing  the business  operations  of the Company  during the period
covered by such statements. The monthly statements furnished pursuant to Section
7.02(c) shall be  accompanied  by a statement  describing  any material  events,
transactions or deviations  from the Company's  Business Plan (as defined below)
contemplated  by Section 7.19 and  containing an  explanation  of the causes and
circumstances thereof.

         7.3.  Certificates of Compliance.  The Company  covenants that promptly
after the occurrence of any default  hereunder or any default under or breach of
any material  agreement,  or any other  material  adverse event or  circumstance
affecting the Company,  it will deliver to  Purchasers an Officers'  Certificate
specifying in reasonable detail the nature and period of existence thereof,  and
what actions the Company has taken and proposes to take with respect thereto.

         7.4.  Other  Reports and  Inspection.  (a) The Company  will furnish to
Purchasers (a) as soon as practicable  after  issuance,  copies of any financial
statements  or reports  prepared by the Company for, or otherwise  furnished to,
its  stockholders  or the Securities  and Exchange  Commission and (b) promptly,
such other  documents,  reports and financial  data as Purchasers may reasonably
request.  In addition the Company  will,  upon  reasonable  prior  notice,  make
available to  Purchasers  or its  representatives  or designees  (a) all assets,
properties and business records of the Company for inspection and/or copying and
(b)  the  directors,  officers  and  employees  of the  Company  for  interviews
concerning the business, affairs and finances of the Company.

         7.5. [Intentionally Omitted.]

         7.6.  Insurance.  The Company will at all times maintain valid policies
of worker's compensation and such other insurance with respect to its properties
and business of the kinds and in amounts not less than is customarily maintained
by corporations  engaged in the same or similar business and similarly situated,
including,  without  limitation,  insurance against fire, loss,  damage,  theft,
public  liability and other risks.  The activities and operations of the Company
shall be conducted in a manner to as to conform in all material  respects to all
applicable provisions of such policies.

         7.7. Use of Proceeds;  Restriction  on Payments.  The Company shall use
the net  proceeds  from the sale of the Bridge  Notes and Warrants to bridge its
working  capital needs through such time as it can consummate an offering of its
securities.  The  Company  covenants  and agrees  that it will not  directly  or
indirectly use any of the proceeds to (i) repay any indebtedness of the Company,
including but not limited to any indebtedness to officers, employees,  directors
or  principal  stockholders  of the  Company,  but  excluding  accounts  payable
incurred  in the  ordinary  course of  business or (ii)  redeem,  repurchase  or
otherwise  acquire  any equity  security  of the  Company.  Notwithstanding  the
foregoing,  the Company  shall not make any payments to any parties which exceed
$10,000 without the prior written consent of the Partnership and the Trust.

         7.8. Material  Changes.  The Company will promptly notify Purchasers of
any material  adverse change in the business,  properties,  assets or condition,
financial or otherwise,  of the Company,  or any other material adverse event or
circumstance  affecting  the  Company,  and of any  litigation  or  governmental
proceeding  pending or, to the knowledge of the Company,  threatened against the
Company or against any director or officer of the Company.

         7.9.   Transactions  with  Affiliates.   Except  for  the  transactions
contemplated  by  this  Agreement,  the  Company  shall  not (a)  engage  in any
transaction  with,  (b) make any loans  to,  nor (c)  enter  into any  contract,
agreement or other  arrangement (i) providing for (x) the employment of, (y) the
furnishing of services by, or (z) the rental of real or personal  property from,
or (ii) otherwise  requiring payments to, any officer,  director or 


                              Page 25 of 99 Pages


<PAGE>

key  employee  of the  Company  or any  relative  of such  persons  or any other
"affiliate"  or  "associate"  of such  persons (as such terms are defined in the
rules and regulations  promulgated under the Securities Act),  without the prior
written approval of the Partnership and the Trust.

         7.10.  Corporate  Existence,   Licenses  and  Permits;  Maintenance  of
Properties;  New Businesses.  The Company will at all times conduct its business
in the  ordinary  course and cause to be done all things  necessary to maintain,
preserve and renew its existence and will preserve and keep in force and effect,
all  licenses,  permits and  authorizations  necessary to the conduct of its and
their  respective  businesses.  The  Company  will  also  maintain  and keep its
properties in good repair,  working order and condition,  and from time to time,
to make all needful and proper repairs,  renewals and replacements,  so that the
business  carried on in connection  therewith  may be properly  conducted at all
times.

         7.11. Other Material Obligations. The Company will comply with, (a) all
material  obligations which it is subject to, or becomes subject to, pursuant to
any contract or  agreement,  whether oral or written,  as such  obligations  are
required to be observed or performed, unless and to the extent that the same are
being contested in good faith and by appropriate proceedings and the Company has
set aside on its books  adequate  reserves  with  respect  thereto,  and (b) all
applicable laws,  rules, and regulations of all  governmental  authorities,  the
violation of which could have a material adverse effect upon the business of the
Company.

         7.12.  Amendment to the Certificate of  Incorporation  and the By-Laws.
The  Company  will  perform  and be in  compliance  with and  observe all of the
provisions  set forth in its  Certificate  of  Incorporation  and By-Laws to the
extent that the performance of such obligations is legally permissible; provided
that the fact that performance is not legally  permissible will not prevent such
nonperformance  from constituting an event of default under this Agreement.  The
Company  will not amend its  Certificate  of  Incorporation  or  By-Laws  or any
Certificate  of  Designations  for any other  series of  Preferred  Stock of the
Company so as to adversely affect the rights of Purchasers under this Agreement,
the Certificate of  Incorporation,  the By-Laws,  the Warrants,  the Notes,  the
Security Agreement or the Series D Preferred Stock Certificate of Designations.

         7.13.  Merger;  Sale of Assets.  The Company will not become a party to
any merger, consolidation or reorganization, or sell, lease, license, sublicense
or  otherwise  dispose of all or  substantially  all of its assets,  without the
prior approval of Purchasers.

         7.14.  Acquisition.  The Company  will not acquire any  interest in any
business  from any  person,  firm or entity  (whether  by a purchase  of assets,
purchase  of  stock,   merger  or  otherwise)  without  the  prior  approval  of
Purchasers,  except the  acquisition  of 1% or less of any class of  outstanding
securities of a company  whose  securities  are listed on a national  securities
exchange or which has not fewer than 1,000  stockholders and except as otherwise
specifically permitted pursuant to the provisions of this Agreement.

         7.15. Dividends;  Distributions;  Repurchases of Common Stock; Treasury
Stock.  The Company shall not declare or pay any dividends on, or make any other
distribution  with  respect to, its  capital  stock,  whether  now or  hereafter
outstanding,  or purchase,  acquire,  redeem or retire any shares of its capital
stock, without the consent of Purchasers, provided, however, the foregoing shall
not prohibit the Company from  repurchasing  any shares of its Common Stock from
any present or former officer, Director or employee of the Company, or complying
with the terms and  provisions  of the  Series A  Preferred  Stock and  Series C
Preferred Stock.

         7.16.  Consents and Waivers.  (a) Except as set forth on Schedule 7.16,
the Company has obtained all consents and waivers needed to enable it to perform
all of its obligations  under this Agreement and the  transactions  contemplated
hereby.

         (b) Except as set forth on Schedule 7.16, the Company has obtained from
all holders of options,  warrants and other securities of the Company having any
right  of  first  refusal,   offer,  sale,  negotiation  or  similar  rights  or
antidilution or other rights to have the terms (including,  without  limitation,
conversion or exercise prices or rates) of such  instruments  adjusted by virtue
of the purchase and sale of the Notes and the Warrants or the other transactions
contemplated  by  this  Agreement,  a  written  waiver  in  form  and  substance
satisfactory to Purchasers and their counsel.


                              Page 26 of 99 Pages


<PAGE>

         7.17.  Taxes and Liens.  The Company will duly pay and  discharge  when
payable, all taxes, assessments and governmental charges imposed upon or against
the Company or its properties, or any part thereof or upon the income or profits
therefrom,  in each case before the same become  delinquent and before penalties
accrue thereon, as well as all claims for labor,  materials or supplies which if
unpaid  might by law become a lien upon any of its  property,  unless and to the
extent  that the same are  being  contested  in good  faith  and by  appropriate
proceedings  and the Company has set aside on its books  adequate  reserves with
respect thereto.

         7.18.  Restrictive  Agreement.  The Company  covenants  and agrees that
subsequent to the Closing, it will not be a party to any agreement or instrument
which by its terms would restrict the Company's  performance of its  obligations
pursuant to this  Agreement,  the  Certificate of  Incorporation,  By-laws,  the
Warrants or the Notes.

         7.19.  Business  Plan.   Commencing  with  the  Company's  fiscal  year
commencing  January 1,  1997,  the  Company's  Chief  Financial  Officer or Vice
President--  Finance  shall  prepare or have prepared and submit to the Board of
Directors  not less than 60 days prior to the  beginning  of each fiscal year of
the Company,  an updated business plan (the "Business Plan") for such year which
shall set forth the  Company's  product  development,  marketing  and  servicing
plans,  capital expenditures and expense budgets and shall encompass a statement
of long range strategy over a five-year  period and  short-range  tactics over a
two-year  period.  The Business Plan shall specify  quantitative and qualitative
goals for the Company and relate the  attainment of those goals to the Company's
strategic objectives.

         7.20.  Director and Observer.  (a) For a period of five years after the
Closing  Date,  the  Partnership  and the Trust shall be entitled to designate a
majority of the voting Directors of the Company provided,  however,  that in the
event that the Company has not obtained Future  Financings (as defined below) in
excess of  $3,500,000  on or before the date which is 6 months  after the Bridge
Closing Date (as defined in Exhibit B), then the Partnership and the Trust shall
have the right to appoint only 2 Directors or observers and the remainder of the
Partnership and the Trust's designated  Directors shall resign. In addition,  if
the holders of the Series A Preferred  Stock  exercise their right to appoint up
to 2 additional  Directors pursuant to Section 9(c) of the Restated  Certificate
of  Incorporation  of  the  Company  (the  "Restated  Certificate"),   then  the
Partnership  and the Trust  shall have the right to  appoint up to 2  additional
Directors  per  Director  appointed  by the Series A  Preferred  Stock.  "Future
Financings"  shall  mean the  aggregate  gross  proceeds  of any sales of equity
securities  of  the  Company  (including  the  Notes  or  any  other  securities
convertible  into equity  securities  of the Company),  and the aggregate  gross
proceeds of any corporate  partnering or corporate licensing  transactions,  but
shall  exclude  the sale of  products in the  ordinary  course of  business  and
revenues  resulting from any agreement in effect as of the Closing Date. Without
limiting the generality of the foregoing,  such Future Financing  includes:  (a)
all  payments  made for equity  securities,  equity  security  rights or similar
rights, (b) technology  acquisition or access fees or similar up-front payments,
(c) other future  payments to be made to the Company,  any of its  affiliates or
its employees  for the benefit of the Company,  for which the payor is obligated
either absolutely or upon the attainment of milestones,  (d) funding provided by
any  investor  (through  reimbursement  or  otherwise)  relative to research and
development,  clinical trials and related expenditures,  provided that such work
is  performed  or managed by the  Company or any of its  affiliates  and (e) the
repayment or assumption by any party of obligations of the Company or any of its
affiliates,  including  indebtedness  for money  borrowed or amounts owed by the
Company or any of its affiliates to


                                 Page of Pages


<PAGE>

inventors  or  owners  of  technology.  It is  further  understood  that  Future
Financings shall not be reduced by the amount of any expenses,  fees,  discounts
or commissions incurred during the undertaking of such financing.  If necessary,
the  Directors  of the  Company  will  elect  each  such  person to the Board of
Directors  of the Company by creating a new  position on the Board of  Directors
promptly  following  such person's  nomination by Purchasers  and shall nominate
such person for election in connection with any stockholder  vote for Directors,
and the Company will use its best efforts to ensure that the stockholders of the
Company agree to vote all their  securities in favor of such person's  election.
The Company  agrees to vote all voting  securities  for which the Company  holds
proxies,  granting it voting  discretion,  or is otherwise  entitled to vote, in
favor of, and to use its best  efforts in all respect to cause,  the election of
each such  individual  proposed by the  Partnership  and the Trust. In the event
that a vacancy is created  on the Board of  Directors  at any time by the death,
disability,  resignation  or  removal  (with  or  without  cause)  of  any  such
individual proposed and nominated by the Partnership and the Trust,  pursuant to
this  Agreement,  the Company will, and will use its best efforts to ensure that
the  stockholders of the Company, vote 


                              Page 27 of 99 Pages


<PAGE>

all its voting  securities to elect each individual  proposed by the Partnership
and the Trust and  approved  by the Company and  nominated  for  election by the
Partnership and the Trusts to fill such vacancy and serve as a voting Director.

         (b) In  addition to the rights set forth in Section  7.20(a),  from and
after the Closing Date,  until such time as Purchasers or their affiliates shall
not  beneficially  own any securities of the Company,  the  Partnership  and the
Trust shall be entitled to designate  nonvoting  observers who shall be entitled
to attend all meetings of the Board of Directors and any of its  committees  and
who shall be provided (i)  reasonable  prior notice of all meetings of the Board
of Directors  and any of its  committees,  (ii)  reasonable  prior notice of any
action that the Board of Directors or any of its  committees may take by written
consent,  (iii)  promptly  delivered  copies of all minutes and other records of
action by, and all written  information  furnished to, the Board of Directors or
any of its committees and (iv) any other information  requested by such observer
which a member  of the  Board of  Directors  would be  entitled  to  request  to
discharge his or her duties. Such observers shall be entitled to the same rights
to  reimbursement  for the  expense of  attendance  at  meeting  as any  outside
Director.

         (c) If the  Partnership  and the Trust give notice to the Company  that
the  Partnership  and the  Trust  desire to remove a  Director  proposed  by the
Partnership  and the Trust pursuant to this  Agreement,  the Company shall,  and
shall use its best effort to ensure that the  stockholders of the Company shall,
vote all its voting  securities  in favor of removing such Director if a vote of
holders of such  securities  shall be required to remove the  Director,  and the
Company agrees to take any action necessary to facilitate such removal.

         (d) Each Director  nominated by the  Partnership and the Trust shall be
entitled  to the same type and an amount of  compensation  at least equal to the
highest amount payable to any other Director for serving in such capacity.

         (e) Concurrently with the Closing Date, if requested by the Partnership
and the Trust,  the  Company  shall have caused the  appointment  of the initial
Directors  nominated by the Partnership and the Trust, to its Board of Directors
in accordance with the provisions of this Section 7.20, which  individuals shall
be identified in writing to the Company by such time.

         (f) At any time that a designee or designees of the Partnership and the
Trust serve on the Company's  Board of Directors,  the Partnership and the Trust
shall be entitled to  representation  on any committee of the Board of Directors
proportionate with their representation of the Board as a whole.

         7.21. Board of Directors. (a) The Company shall promptly reimburse each
director or observer of the Company  designated by the Partnership and the Trust
who  is not an  employee  of the  Company  for  all of his  reasonable  expenses
incurred in  attending  each meeting of the Board of Directors of the Company or
any committee thereof.

         (b) The Company shall at all times  maintain  provisions in its By-laws
and/or Certificate of Incorporation indemnifying all directors against liability
and absolving all directors from  liability to the Company and its  stockholders
to the maximum extent permitted under the laws of the State of Delaware.

         (c)  The  By-laws  of  the  Company  shall  always  contain  provisions
consistent  with the  provisions  of this Section 7.21 except to the extent this
Section 7.21 deals with the possible observer.

         (d) For so long as any  designee  of  Purchasers  is a director  of the
Company,  procure and maintain Director and Officer  Liability  Insurance with a
reputable insurance carrier.

         7.22.  No  Subsidiaries.  The  Company  will not create or acquire  any
entity  that would be a  Subsidiary  (as  defined in Section  9.10)  without the
Partnership's and the Trust's consents.

         7.23.  Publicity.  (a) The Company shall not issue any press release or
make any  other  public  announcement  with  respect  to this  Agreement  or the
transactions  contemplated  hereby or utilizing the names of Purchasers or their
officers, directors, employees, agents or affiliates without obtaining the prior
approval of Purchaser,  except 


                              Page 28 of 99 Pages
<PAGE>

as may be required by law or the  regulations of any securities  exchange or the
Nasdaq National Market.

         (b)  Except  as may be  required  by  law  or  the  regulations  of any
securities  exchange  or the  Nasdaq  National  Market,  the  Company  shall not
disclose the names, identity,  addresses or any other information regarding each
of the Purchasers or any of its officers,  directors,  employees,  shareholders,
nominees  and/or  designees  without such  Purchaser's  prior  written  consent;
provided,  however,  each of the names of Purchasers (but not its addresses) may
be disclosed in the Shelf Registration Statement.

         (c) After the Closing  Date,  upon request of the  Partnership  and the
Trust, the Company shall cause, at its sole expense,  the immediate  publication
of a "tombstone"  advertisement  in the Wall Street Journal  (National  Edition)
announcing the consummation of this Agreement and the transactions  contemplated
herein,  the exact form and substance of which shall be mutually  agreed upon by
the Company and the Partnership and the Trust.

         7.24. Restriction on Securities. (a) During the 18 months following the
Closing  Date,  the  Company  shall not  without  prior  written  consent of the
Partnership  and the  Trust,  issue,  offer  or sell any of its  equity  or debt
securities  (including,  without limitation,  any securities convertible into or
exercisable for such securities);  provided that the Company may issue shares of
Common Stock upon conversion or exercise of the Company's outstanding securities
and  pursuant to exercise of options  under the  Company's  Stock Option Plan in
accordance with the terms of such plan (it being agreed that the issuance of any
additional  options  under such plan may be effected only with the prior written
consent of the Partnership and the Trust;  provided,  further,  that the Company
without the consent of the Partnership and the Trust may issue options under the
Company's  Non-Employee  Director Stock Option Plan in accordance with the terms
of such plan which will not be amended  without the consents of the  Partnership
and the Trust); provided, further, that this Section 7.24 shall not apply to the
offerings to be conducted by the Company with Paramount Capital,  Inc. acting as
placement agent as contemplated in the Letter Agreement  between the Company and
Paramount  Capital,  Inc.  dated as of January 28,  1997.  During the  18-months
following  the Closing Date,  the Company  shall not,  without the prior written
consents  of the  Partnership  and the  Trust,  offer or sell any of its debt or
equity  securities in reliance on Regulation S of the Securities Act. During the
36-month  period  following  the Closing  Date,  the Company will not extend the
expiration date or lower the exercise price of any options or warrants,  or take
any similar  action with respect to any  convertible  securities of the Company,
without the prior written consents of the Partnership and the Trust.

         (b) Prior to the Closing  Date,  the Company  shall  obtain the written
agreement of all executive  officers and directors of the Company (and shall use
its  best  efforts  to  obtain  a  wrtten  agreement  from  all  5%  or  greater
stockholders  of the  Company) to  "lock-up"  all of the shares of Common  Stock
owned by each of them at any time until 24 months  following  the Closing  Date,
and to agree not to directly or indirectly, issue, agree or offer to sell, grant
an option for the purchase or sale, assign, sell, contract to sell, sell "short"
or "short  against the box" (as those terms are generally  understood),  pledge,
hypothecate,  distribute  or  otherwise  encumber or dispose of, any such shares
(including  options,  rights,  warrants or other  securities  convertible  into,
exchangeable,  exercisable  for or evidencing any right to purchase or subscribe
for shares of capital stock of the Company (whether or not beneficially owned by
the undersigned) or any beneficial  interest therein of any shares of the Common
Stock,  all in form and substance  satisfactory to the Partnership and the Trust
and their counsel.

         7.25.  Restriction on Liens. The Company shall not create or permit the
imposition  of any liens on any of its assets  from and after the  Closing  Date
without the prior written consent of the Partnership and the Trust.

         7.27.  Restrictions  on  Indebtedness.  The  Company  shall not  incur,
create,  assume  or permit to exist any  indebtedness  except  (i)  indebtedness
represented by the Notes, (ii)  indebtedness  which by its terms is subordinated
to the Notes in an amount less than $25,000 in the aggregate (iii)  indebtedness
in an amount less than fifty thousand dollars ($50,000) incurred in the ordinary
course of business,  and (iv)  indebtedness  for borrowed  money existing on the
date  hereof and  disclosed  in writing to the Holder,  but not any  extensions,
renewals or replacements of such indebtedness.

         7.28. Repayment Upon Certain Events. In the event that the Company does
not obtain the  Required  Shareholder  Approvals  (as  hereafter  defined),  the
Company shall, on 


                              Page 29 of 99 Pages


<PAGE>

the date that the Required Shareholder Approvals are denied,  immediately pay to
the Purchasers by wire transfer $3,000,000 or in the event that the Company does
not have $3,000,000, the remainder of the money that the Company has as a result
of the  investment  made by  Purchasers  in the  Company  pursuant  to the terms
hereof.  The "Required  Shareholder  Approvals" shall mean the authorization and
approval  by the holders of Common  Stock of the Company of the  issuance of the
Notes,  the issuance of the shares of Series D Preferred Stock  underlying these
Notes,  the  Bridge  Warrants  or the New  Warrants  (as  defined  in the Bridge
Warrants),  or any Common  Stock  underlying  the  foregoing  to the extent such
authorization  is necessary  pursuant to the rules of the Nasdaq National Market
or any other applicable law, rule or regulation.

         8. Registration of Common Stock.

         8.1.  Registration.  (i) Not later than 30 days after consummation of a
Qualified  Offering  (as  defined  below) or, (ii) in the event that a Qualified
Offering (as defined  below) has not been  consummated  by the date which is 180
days after the Closing Date,  immediately  thereafter and in no event later than
the date which is 195 days from the Closing Date,  the Company will file a shelf
registration statement (the "Shelf Registration  Statement") with respect to the
resale  of  the   Registrable   Securities  with  the  Securities  and  Exchange
Commission.  The Company will use its best efforts to effect the  registrations,
qualifications or compliances (including,  without limitation,  the execution of
any  required  undertaking  to  file  post-effective   amendments,   appropriate
qualifications  under  applicable  blue sky or other state  securities  laws and
appropriate   compliance  with  applicable  securities  laws,   requirements  or
regulations)  as may be  reasonably  requested and as would permit or facilitate
that sale and distribution of all Registrable  Securities until the distribution
thereof is complete.  A "Qualified  Offering"  shall mean any equity offering or
series of Offerings with gross proceeds in excess of $2,500,000.

         8.2.  Registration  Procedures.  In connection with the registration of
any Registrable  Securities under the Securities Act as provided in this Section
8, the Company will use its best efforts, as expeditiously as possible:

         (a) Prepare and file with the  Securities  and Exchange  Commission the
Shelf Registration Statement with respect to such Registrable Securities and use
its best efforts to cause such Shelf Registration Statement to become effective;

         (b) Prepare and file with the Securities and Exchange  Commission  such
amendments  and  supplements  to  such  Shelf  Registration  Statement  and  the
prospectus  used in connection  therewith as may be necessary to keep such Shelf
Registration  Statement  effective  until the  disposition  of all securities in
accordance  with the intended  methods of  disposition  by the seller or sellers
thereof set forth in such Shelf Registration  Statement shall be completed,  and
to comply with the provisions of the Securities Act (to the extent applicable to
the Company) with respect to such dispositions;

         (c) Furnish to each seller of such  Registrable  Securities such number
of copies of such Shelf  Registration  Statement and of each such  amendment and
supplement thereto (in each case including all exhibits),  such number of copies
of the prospectus included in such Shelf Registration  Statement (including each
preliminary  prospectus),  in conformity with the requirements of the Securities
Act, and such other documents,  as such seller may reasonably  request, in order
to  facilitate  the  disposition  of the  Registrable  Securities  owned by such
seller;

         (d) Use its best  efforts  to  register  or  qualify  such  Registrable
Securities  covered  by such  Shelf  Registration  Statement  under  such  other
securities  or blue  sky laws of such  jurisdictions  as any  seller  reasonably
requests,  and do any and all other  acts and  things  which  may be  reasonably
necessary or advisable to enable such seller to consummate  the  disposition  in
such  jurisdictions of the Registrable  Securities owned by such seller,  except
that the Company will not for any such purpose be required to qualify  generally
to do business as a foreign  corporation  in any  jurisdiction  wherein it would
not,  but for the  requirements  of  this  Section  8.2(d)  be  obligated  to be
qualified, to subject itself to taxation in any such jurisdiction, or to consent
to general service of process in any such jurisdiction;

         (e) Provide a transfer  agent and  registrar  for all such  Registrable
Securities  covered  by such  Shelf  Registration  Statement  not later than the
effective date of such Shelf Registration Statement;


                              Page 30 of 99 Pages


<PAGE>

         (f) Notify each seller of such Registrable  Securities at any time when
a prospectus  relating  thereto is required to be delivered under the Securities
Act, of the happening of any event as a result of which the prospectus  included
in such Shelf Registration  Statement contains an untrue statement of a material
fact or omits any fact necessary to make the statements  therein not misleading,
and, at the request of any such seller, the Company will prepare a supplement or
amendment to such prospectus so that, as thereafter  delivered to the purchasers
of such  Registrable  Securities,  such  prospectus  will not  contain an untrue
statement  of a material  fact or omit to state any fact  necessary  to make the
statements therein not misleading;

         (g)  Cause  all  such  Registrable  Securities  to be  listed  on  each
securities  exchange  or  automated  over-the-counter  trading  system  on which
similar securities issued by the Company are then listed;

         (h)  Enter  into  such  customary  agreements  and take all such  other
actions  as  reasonably   required  in  order  to  expedite  or  facilitate  the
disposition of such Registrable Securities; and

         (i)  Make  available  for  inspection  by  any  seller  of  Registrable
Securities, all financial and other records, pertinent corporation documents and
properties  of the Company,  and cause the  Company's  officers,  directors  and
employees to supply all information  reasonably  requested by any such seller in
connection with the Shelf Registration Statement pursuant to Section 8.1.

         8.3 Registration and Selling Expenses. (a) All expenses incurred by the
Company in connection with the Company's  performance of or compliance with this
Section 8, including,  without  limitation (i) all  registration and filing fees
(including  all  expenses  incident to filing with the National  Association  of
Securities Dealers, Inc.), (ii) blue sky fees and expenses,  (iii) all necessary
printing and duplicating expenses and (iv) all fees and disbursements of counsel
and  accountants  for the  Company  (including  the  expenses  of any  audit  of
financial  statements),  retained by the Company (all such expenses being herein
called "Registration Expenses"), will be paid by the Company except as otherwise
expressly provided in this Section 8.3.

         (b) The Company will, in any event, in connection with any registration
statement,  pay  its  internal  expenses  (including,  without  limitation,  all
salaries and expenses of its officers and employees performing legal, accounting
or other  duties in  connection  therewith  and  expenses  of audits of year-end
financial  statements),  the expense of liability insurance and the expenses and
fees for listing  the  securities  to be  registered  on one or more  securities
exchanges  or  automated  over-the-counter  trading  systems  on  which  similar
securities issued by the Company are then listed.

         (c) Nothing  herein shall be construed to prevent any holder or holders
of  Registrable  Securities  from  retaining  such  counsel  (the  Trust and the
Partnership  to be limited to one counsel  representing  them both and any other
purchasers to be  represented by one counsel  separately  from the Trust and the
Partnership)  as they shall choose,  the expenses of which shall be borne by the
Company.

         8.4. Other Public Sales and  Registrations.  The Company agrees that it
will  not,  on its own  behalf,  file or cause to  become  effective  any  other
registration  of any of its  securities  under the  Securities  Act or otherwise
effect a public  sale or  distribution  of its  securities  (except  pursuant to
registration on Form S-8 or any successor form relating to a special offering to
the employees or security  holders of the Company)  until at least 180 days have
elapsed  after  the  effective  date of the  Shelf  Registration  Statement.  In
addition,  the Company  agrees that it will use its best efforts to obtain prior
to the  filing of the Shelf  Registration  Statement  an  agreement  in form and
substance  satisfactory  to  Purchasers  and  their  counsel  in their  sole and
absolute discretion from each person that has the right to have the Company file
or cause to become  effective any other  registration  of any of its  securities
under the Securities Act or otherwise  effect a public sale or  distribution  of
its securities  (except  pursuant to  registration  on Form S-8 or any successor
form relating to a special  offering to the employees or security holders of the
Company),  pursuant  to which each such person will agree for the benefit of the
Company and  Purchasers to waive any and all such rights until at least 180 days
have elapsed after the effective date of the Shelf Registration Statement.

         8.5.  Indemnification.  (a) The Company hereby agrees to indemnify,  to
the extent permitted by law, each holder of Registrable Securities, its officers
and 


                              Page 31 of 99 Pages


<PAGE>

directors,  if any, and each person, if any, who controls such holder within the
meaning of the Securities Act, against all losses, claims, damages,  liabilities
and expenses (under the Securities Act or common law or otherwise) caused by any
untrue statement or alleged untrue statement of a material fact contained in any
registration  statement or  prospectus  (and as amended or  supplemented  if the
Company has furnished any amendments or supplements  thereto) or any preliminary
prospectus,  which registration statement,  prospectus or preliminary prospectus
shall be prepared  in  connection  with the  registration  contemplated  by this
Section 8, or caused by any  omission  or alleged  omission  to state  therein a
material fact required to be stated  therein or necessary to make the statements
therein  not  misleading,  except  insofar  as  such  losses,  claims,  damages,
liabilities  or expenses are caused by any untrue  statement  or alleged  untrue
statement  contained in or by any omission or alleged  omission from information
furnished  in  writing by such  holder to the  Company  in  connection  with the
registration  contemplated  by this Section 8,  provided the Company will not be
liable pursuant to this Section 8.5 if such losses, claims, damages, liabilities
or expenses have been caused by any selling security holder's failure to deliver
a copy  of the  registration  statement  or  prospectus,  or any  amendments  or
supplements thereto, after the Company has furnished such holder with the number
of copies required by Section 8.2(c).

         (b) In connection with any registration  statement in which a holder of
Registrable  Securities is participating,  each such holder shall furnish to the
Company in writing such  information  as is reasonably  requested by the Company
for use in any such  registration  statement or prospectus and shall  severally,
but not jointly,  indemnify,  to the extent  permitted by law, the Company,  its
directors and officers and each person,  if any, who controls the Company within
the  meaning  of the  Securities  Act,  against  any  losses,  claims,  damages,
liabilities and expenses  resulting from any untrue  statement or alleged untrue
statement of a material  fact or any omission or alleged  omission of a material
fact  required to be stated in the  registration  statement or prospectus or any
amendment  thereof or  supplement  thereto or necessary  to make the  statements
therein not  misleading,  but only to the extent such losses,  claims,  damages,
liabilities  or expenses  are caused by an untrue  statement  or alleged  untrue
statement contained in or by an omission or alleged omission from information so
furnished  in  writing  by such  holder  in  connection  with  the  registration
contemplated  by  this  Section  8.  If  the  offering   pursuant  to  any  such
registration is made through underwriters, each such holder agrees to enter into
an  underwriting  agreement  in  customary  form with such  underwriters  and to
indemnify such  underwriters,  their  officers and  directors,  if any, and each
person who controls such  underwriters  within the meaning of the Securities Act
to the same extent as hereinabove  provided with respect to  indemnification  by
such holder of the Company. Notwithstanding the foregoing or any other provision
of this  Agreement,  in no event  shall a holder of  Registrable  Securities  be
liable for any such losses, claims,  damages,  liabilities or expenses in excess
of the lesser of (a) the net proceeds received by such holder in the offering or
(b) $1,000,000.

         (c) Promptly  after receipt by an  indemnified  party under Section 8.5
(a) or (b) of notice of the  commencement  of any  action  or  proceeding,  such
indemnified  party  will,  if a claim in  respect  thereof is made  against  the
indemnifying party under such Section,  notify the indemnifying party in writing
of the  commencement  thereof;  but the  omission so to notify the  indemnifying
party  will  not  relieve  it  from  any  liability  which  it may  have  to any
indemnified party otherwise than under such Section.  In case any such action or
proceeding  is brought  against  any  indemnified  party,  and it  notifies  the
indemnifying party of the commencement  thereof,  the indemnifying party will be
entitled to participate therein, and, to the extent that it wishes, jointly with
any other indemnifying party similarly notified,  to assume the defense thereof,
with  counsel  approved by such  indemnified  party,  and after  notice from the
indemnifying  party to such  indemnified  party of its election so to assume the
defense thereof,  the indemnifying  party will not be liable to such indemnified
party  under  such  Section  for any  legal or any other  expenses  subsequently
incurred by such indemnified party in connection with the defense thereof (other
than reasonable costs of  investigation)  unless incurred at the written request
of the indemnifying party. Notwithstanding the above, the indemnified party will
have the  right to  employ  counsel  of its own  choice  in any such  action  or
proceeding if the indemnified  party has reasonably  concluded that there may be
defenses  available to it which are different from or additional to those of the
indemnifying  party, or counsel to the indemnified  party is of the opinion that
it  would  not  be  desirable  for  the  same  counsel  to  represent  both  the
indemnifying party and the indemnified party because such  representation  might
result in a conflict  of  interest  (in either of which  cases the  indemnifying
party  will not have the  right to  assume  the  defense  of any such  action or
proceeding  on behalf of the  indemnified  party or  parties  and such legal and
other expenses 


                              Page 32 of 99 Pages


<PAGE>

will be borne by the  indemnifying  party).  An  indemnifying  party will not be
liable  to any  indemnified  party  for any  settlement  of any such  action  or
proceeding effected without the consent of such indemnifying party.

         (d) If the  indemnification  provided  for in Section  8.5(a) or (b) is
unavailable  under  applicable  law to an  indemnified  party in  respect of any
losses, claims, damages or liabilities referred to therein, then each applicable
indemnifying  party,  in lieu of  indemnifying  such  indemnified  party,  shall
contribute to the amount paid or payable by such  indemnified  party as a result
of  such  losses,  claims,  damages  or  liabilities  in such  proportion  as is
appropriate  to reflect the relative fault of the Company on the one hand and of
the  holders  of  Registrable  Securities  on the other in  connection  with the
statements  or omissions  which  resulted in such losses,  claims,  damages,  or
liabilities,  as  well  as any  other  relevant  equitable  considerations.  The
relative  fault of the Company on the one hand and of the holders of Registrable
Securities on the other shall be determined by reference to, among other things,
whether  the  untrue or  alleged  untrue  statement  of a  material  fact or the
omission to state a material fact relates to information supplied by the Company
or by the holders of Registrable  Securities and the parties'  relative  intent,
knowledge,  access to  information  and  opportunity  to correct or prevent such
statement or omission.  The amount paid or payable by a party as a result of the
losses,  claims,  damages and  liabilities  referred to above shall be deemed to
include,  subject to the limitations  set forth in Section 8.5(c),  any legal or
other fees or  expenses  reasonably  incurred by such party in  connection  with
investigating  or defending any action or claim.  No person guilty of fraudulent
misrepresentation  (within the meaning of Section 11(f) of the  Securities  Act)
will be  entitled  to  contribution  from any  person  who is not guilty of such
fraudulent misrepresentation.

         (e) Promptly  after  receipt by the Company or any holder of Securities
of notice of the commencement of any action or proceeding, such party will, if a
claim for  contribution  in respect  thereof is to be made against another party
(the  "contributing  party"),  notify the contributing party of the commencement
thereof;  but the omission so to notify the contributing  party will not relieve
it from any  liability  which  it may have to any  other  party  other  than for
contribution  hereunder. In case any such action, suit, or proceeding is brought
against  any  party,  and  such  party  notifies  a  contributing  party  of the
commencement  thereof,  the  contributing  party will be entitled to participate
therein with the  notifying  party and any other  contributing  party  similarly
notified.

         8.6.  Additional Common Stock Issuable Upon Delay of Registration.  (a)
Except to the extent any delay is due to the  failure of a holder to  reasonably
cooperate in providing to the Company such  information  as shall be  reasonably
requested by the Company in writing for use in the Shelf Registration Statement,
if the  Shelf  Registration  Statement  is not  filed  with the  Securities  and
Exchange  Commission  within the target dates set forth in the first sentence of
Section 8.1 (the "Outside  Target Date"),  the Company shall declare and pay for
no additional  consideration  to Purchasers  additional  Bridge  Warrants or New
Warrants,  as the case may be,  equal to 1.5% of the Bridge  Warrants or the New
Warrants,  as the case may be,  then held by  Purchasers  for each day after the
Outside Target Date that the Registration Statement remains unfiled.

         (b) If the Shelf  Registration  Statement is not declared  effective by
the  Securities  and Exchange  Commission  within 210 days following the Closing
Date (the "Targeted  Effective Date"),  the Company shall declare and pay for no
additional  consideration  to  Purchasers  additional  Bridge  Warrants  or  New
Warrants,  as the case may be,  equal to 1.5% of the Bridge  Warrants or the New
Warrants,  as the case may be,  then held by  Purchasers  for each day the Shelf
Registration  Statement is not declared effective by the Securities and Exchange
Commission following the occurrence of the Targeted Effective Date.

         (c) All shares of Common Stock issuable  pursuant to Section 8.6(a) and
(b) shall be duly  authorized,  fully  paid and  nonassessable  shares of Common
Stock and shall be included in the Shelf Registration  Statement contemplated by
Section 8.1. Such shares shall be registered in Purchasers' names or the name of
the nominee(s) of Purchasers in such  denominations  as Purchasers shall request
pursuant to instructions delivered to the Company.

         9.  Certain  Definitions.  For  the  purposes  of  this  Agreement  the
following terms have the respective meanings set forth below:


                              Page 33 of 99 Pages


<PAGE>

         9.1.  "Affiliate" means any person,  corporation,  firm or entity which
directly or indirectly  controls,  is controlled  by, or is under common control
with the indicated person, corporation, firm or entity.

         9.2. "Common Stock" means the Company's Common Stock.

         9.3.  "Generally   Accepted  Accounting   Principles"  means  generally
accepted accounting principles consistently applied.

         9.4. "Officers'  Certificate" means a certificate executed on behalf of
the Company by its President,  Chairman of the Board,  Chief Executive  Officer,
Chief Financial Officer,  Vice  President--Finance,  Secretary and/or one of its
other Vice- Presidents.

         9.5. "Registrable  Securities" means (i) the Common Stock issuable upon
conversion of the Series D Preferred Stock  underlying the Notes and exercise of
the  Warrants  purchased  pursuant  to Section  1.1 or (ii) any other  shares of
Common Stock now owned or hereafter acquired by Purchasers (whether Common Stock
owned  directly  or  underlying  convertible  securities  of the  Company).  For
purposes  of this  Agreement,  any shares of Common  Stock  issued  pursuant  to
Section 8.6 shall be deemed to be  Registrable  Securities and shall be included
in the Shelf Registration Statement contemplated by Section 8.1.

         9.6. "Securities" means the Notes, the Warrants and any Preferred Stock
or Common  Stock  underlying  the  foregoing  whether  issued at the  Closing or
thereafter.

         9.7.  "Securities  Act" means, as of any given time, the Securities Act
of 1933, as amended, or any similar federal law then in force.

         9.8.  "Securities  Exchange  Act"  means,  as of any  given  time,  the
Securities  Exchange Act of 1934, as amended, or any similar federal law then in
force.

         9.9.  "Securities and Exchange  Commission"  includes any  governmental
body or agency succeeding to the functions thereof.

         9.10.  "Subsidiary"  means any person,  corporation,  firm or entity at
least the majority of the equity  securities (or  equivalent  interest) of which
are, at the time as of which any determination is being made, owned of record or
beneficially by the Company,  directly or indirectly,  through any Subsidiary or
otherwise.

         10.1 Company Indemnities.  (a) The Company agrees to indemnify,  defend
and  hold  Purchasers  and  their  officers,  directors,   partners,  employees,
consultants and agents (the "Purchasers' Indemnitees") harmless from and against
any  liability,  obligation,  claim,  cost,  loss,  judgment,  damage or expense
(including  reasonable  legal fees and expenses)  (collectively,  "Liabilities")
incurred or suffered by any of Purchasers' Indemnitees as a result of or arising
out of or in  connection  with  the  Company's  breach  of  any  representation,
warranty, covenant or agreement of the Company contained herein.

         11. Miscellaneous.

         11.1.   Termination;   Survival  of  Representations,   Warranties  and
Covenants.   Except  as   otherwise   provided   for  in  this   Agreement   all
representations,   warranties,   covenants  and  agreements  contained  in  this
Agreement,  or in any document,  exhibit,  schedule or  certificate by any party
delivered in  connection  herewith  shall  survive the execution and delivery of
this  Agreement and the Closing Date and the  consummation  of the  transactions
contemplated  hereby,  regardless of any investigation  made by Purchasers or on
their behalf.

         11.2.  Expenses.  The  Company  shall  pay  all  its  own  expenses  in
connection with this Agreement and the  transactions  contemplated  herein.  The
Company agrees to pay promptly and save the  Partnership  and the Trust harmless
against  liability for the payment all expenses  incurred by the Company and the
Partnership and the Trust in connection with the preparation and consummation of
the  Agreement  and the  transactions  contemplated  herein,  including  but not
limited  to:  all  costs  and  expenses  under  Section  8,  including   without
limitation, the costs of preparing,  printing and filing with the Securities and
Exchange   Commission   the  Shelf   Registration   Statement  and   amendments,
post-effective  amendments,  and supplements  thereto;  preparing,  printing and
delivering   exhibits  thereto  and  copies  of  the   preliminary,   final  and
supplemental  prospectuses;  preparing,  


                              Page 34 of 99 Pages
<PAGE>

printing and delivering all selling documents,  including but not limited to the
subscription   agreement,   the   warrant   agreement   and  stock  and  warrant
certificates;  legal fees and  disbursements  of the Partnership and the Trusts'
counsel (which amount shall be offset against  payment of the purchase price for
legal  fees that have been  accrued up to such date and the  remainder  of which
shall be paid  within  30 days of  submission  of any  statements  therefor)  in
connection  with the  preparation  and  consummation  of this  Agreement and the
transactions  contemplated  herein,  including  the  legal  fees  and  costs  of
negotiating  and drafting  any  transaction  documents,  due  diligence  and any
necessary   regulatory  filings  (including,   without  limitation,   the  Shelf
Registration Statement, Forms 3, 4 and 5 and Schedule 13-D filings); the cost of
a total of two sets of bound closing  volumes for the  Partnership and the Trust
and  their  counsel;  and the cost of the  tombstone  advertisement  in the Wall
Street  Journal  (National  Edition)  pursuant  to  Section  7.23(c),  provided,
however,  that with respect to costs  incurred as a result of the actual  Bridge
Loan transaction (the "Bridge Loan Costs"),  the Company shall only be obligated
to reimburse the  Partnership  and the Trust in an amount not to exceed $35,000.
The "Bridge Loan Costs" shall not include any costs and expenses  under  Section
8, including  without  limitation,  the costs of preparing,  printing and filing
with the Securities and Exchange Commission the Shelf Registration Statement and
amendments,  post-effective  amendments,  and supplements thereto and preparing,
printing and delivering  exhibits thereto and copies of the  preliminary,  final
and supplemental prospectuses which such costs shall in all cases be paid by the
Company.  The  provisions of this Section shall survive any  termination of this
Agreement  in  all  instances,   including  without   limitation,   (i)  if  the
transactions contemplated by this Agreement have not been consummated or (ii) if
the transactions have been terminated by Purchasers for any reason.

         11.3.  Amendments and Waivers.  Except for the letter agreement between
the parties hereto and Paramount Capital,  Inc. dated as of January 28, 1997 and
the Operative  Documents,  this Agreement and all exhibits and schedules  hereto
set forth the entire  agreement  and  understanding  among the parties as to the
subject  matter  hereof  and  merges  and  supersedes  all  prior   discussions,
agreements and understandings of any and every nature among them. This Agreement
may be amended only by mutual  written  agreement of the Company and the holders
of a majority  of  principal  amount of the Notes,  and the Company may take any
action  herein  prohibited  or omit to take any  action  herein  required  to be
performed  by it,  and  any  breach  of any  covenant,  agreement,  warranty  or
representation  may be waived,  only if the  Company  has  obtained  the written
consent or waiver of the holders of a majority of principal  value of the Notes.
No course of dealing  between or among any persons  having any  interest in this
Agreement  will be deemed  effective to modify,  amend or discharge  any part of
this  Agreement or any rights or obligations of any person under or by reason of
this Agreement.

         11.4. Successors and Assigns. This Agreement may not be assigned by the
Company  except with the prior  written  consent of the holders of a majority of
principal value of the Notes.  This Agreement shall be binding upon and inure to
the  benefit  of the  Company  and its  permitted  successors  and  assigns  and
Purchasers and their successors and assigns. The provisions hereof which are for
Purchasers'  benefit as  purchasers or holders of the Notes and the Warrants are
also for the benefit of, and enforceable by, any subsequent holder of such Notes
and Warrants.

         11.5.  Notices.  All notices,  demands and other  communications  to be
given or delivered  under or by reason of the provisions of this Agreement shall
be in writing and shall be deemed to have been given  personally  or when mailed
by certified or registered mail,  return receipt  requested and postage prepaid,
and addressed to the addresses of the  respective  parties set forth below or to
such  changed  addresses  as such  parties  may have fixed by notice;  provided,
however,  that any  notice of change of  address  shall be  effective  only upon
receipt:


                           If to the Company:
                           Genta Incorporated.
                           3550 General Atomics Court
                           Building 9, 2nd Floor
                           San Diego, CA 92121
                           Attn: Thomas Adams


                              Page 35 of 99 Pages


<PAGE>

                           With a Copy to:
                           Pillsbury Madison & Sutro, LLP
                           235 Montgomery Street
                           San Francisco, CA 94104
                           Attn: Thomas E. Sparks, Jr.

                           If to the Partnership or the Trust:
                           Paramount Capital Asset Management, Inc.
                           787 Seventh Avenue
                           New York, NY 10019
                           Attn: David Walner

                           With a Copy to:
                           Kramer, Levin, Naftalis & Frankel
                           919 Third Avenue
                           New York, New York 10022
                           Attention: Ezra Levin

         11.6. Governing Law. The validity, performance, construction and effect
of this  Agreement  shall be governed by the  internal  laws of the State of New
York without giving effect to such State's principles of conflict of laws.

         11.7.  Counterparts.  This  Agreement  may be executed in any number of
counterparts  and,  notwithstanding  that any of the parties did not execute the
same counterpart,  each of such counterparts shall, for all purposes,  be deemed
an  original,  and all  such  counterparts  shall  constitute  one and the  same
instrument binding on all of the parties thereto.

         11.8.  Headings.  The headings of the Sections hereof are inserted as a
matter of  convenience  and for  reference  only and in no way define,  limit or
describe the scope of this Agreement or the meaning of any provision hereof.

         11.9.  Severability.  In the event that any provision of this Agreement
or the application of any provision hereof is declared to be illegal, invalid or
otherwise unenforceable by a court of competent  jurisdiction,  the remainder of
this Agreement  shall not be affected  except to the extent  necessary to delete
such illegal,  invalid or  unenforceable  provision  unless the  provision  held
invalid shall substantially  impair the benefit of the remaining portion of this
Agreement.

         11.10.  Freedom of Action.  (a) The Partnership and the Trust and their
affiliates shall not have any obligation to the Company not to (i) engage in the
same or similar  activities  or lines of  business  as the Company or develop or
market any  products,  services or  technologies  that does or may in the future
compete,  directly or indirectly,  with those of the Company, (ii) invest or own
any interest publicly or privately in, or develop a business  relationship with,
any  corporation,  partnership  or other person or entity engaged in the same or
similar  activities or lines or business as, or otherwise in  competition  with,
the  Company  or (iii) do  business  with any  client,  collaborator,  licensor,
consultant, vendor or customer of the Company. The Partnership and the Trust and
its officers, directors,  employees or former employees and affiliates shall not
have any  obligation,  or be  liable,  to the  Company  solely on account of the
conduct  described in the  preceding  sentence.  In the event that either of the
Partnership or the Trust and any officer, director,  employee or former employee
or affiliate thereof acquires knowledge of a potential  transaction,  agreement,
arrangement  or other matter which may be a corporate  opportunity  for both the
Partnership  and the Trust and the Company,  neither of the  Partnership and the
Trust nor their officers, directors, employees or former employees or affiliates
shall have any duty to communicate  or offer such  corporate  opportunity to the
Company  and  neither  of the  Partnership  and the Trust  nor  their  officers,
directors,  employees or former  employees or affiliates  shall be liable to the
Company for breach of any fiduciary duty, as a stockholder or otherwise,  solely
by reason of the fact that  Partnership  and the Trust or any of their officers,
directors,  employees or former  employees or affiliates  pursue or acquire such
corporate  opportunity for either of the  Partnership or the Trust,  direct such
corporate  opportunity  to another  person or entity or  communicate  or fail to
communicate such corporate opportunity or entity to the Company. As used in this
Section,  the  Partnership  and the  Trust  shall  mean  either  and both of the
Partnership  and the Trust and their  affiliates  (excluding  the  Company as an
affiliate of the Partnership and the Trust).


                              Page 36 of 99 Pages


<PAGE>

         (b) The  provisions of this Section 11.10 shall be  enforceable  to the
fullest extent permitted by law.

         11.11. Rights of Holders Inter Se. Each Holder of securities shall have
the absolute  right to exercise or refrain from  exercising  any right or rights
which  such  Holder  may  have by  reason  of  this  Agreement  or any  security
including,  without  limitation,  the  right to  consent  to the  waiver  of any
obligation  of the Company  under this  Agreement and to enter into an agreement
with the Company for the purpose of modifying  this  Agreement or any  agreement
effecting  such  modification,  and such Holder shall not incur any liability to
any other  Holder or  Holders  of  securities  with  respect  to  exercising  or
refraining from exercising any such right or rights.

         11.12.   Exculpation  Among  Purchasers  and  Holders.  Each  Purchaser
acknowledges and agrees that it is not relying upon any other Purchaser,  or any
officer, director, employee partner or affiliate of any such other Purchaser, in
making its investment or decision to invest in the Company or in monitoring such
investment.  Each Purchaser agrees that no Purchaser nor any controlling person,
officer,  director,  stockholder,  partner,  agent or employee of any  Purchaser
shall be liable for any action  heretofore  or hereafter  taken or omitted to be
taken  by any of them  relating  to or in  connection  with the  Company  or the
securities, or both.

         11.13.  Actions by  Purchasers.  Any actions  permitted  to be taken by
holders or Purchasers of Notes and/or  Warrants or the  Partnership or the Trust
and any consents required to be obtained from the same under this Agreement, may
be taken or given only by, in the case of consents or actions requiring approval
of the  Partnership or the Trust,  by the  Partnership or the Trust,  and in all
other cases,  only by holders of a majority of (i) in the case of the Notes, the
face amount of the principal and (ii) in the case of the Warrants, the number of
underlying   shares  of  Common  Stock,   and  if  such  holders  or  Purchasers
constituting  a majority  the  ("Majority  Holders") as set forth in (i) or (ii)
above or the  Partnership  or Trust take any action or grant any  consent,  such
action or consent  shall be deemed given or taken by all holders or  Purchasers'
who shall be bound by the decision or action  taken by the  Majority  Holders or
the  Partnership  or the Trust without any liability on the part of the Majority
Holders or the  Partnership  or the Trust to any other holder or  Purchasers  of
securities hereto.

         11.14.  Secured Party. The Purchasers hereby acknowledge and agree that
Paramount  Capital,  Inc.  shall act as the secured party (the "Secured  Party")
under and for all purposes of the Security  Agreement.  Without giving notice to
any holder of Notes, the Secured Party shall have full and irrevocable authority
on behalf of the undersigned and all other holders of Notes, with respect to the
Security Agreement,  Financing  Statements,  to (i) deal with the Company,  (ii)
accept and give  notices and other  communications,  (iii)  settle any  disputes
relating to the terms thereof,  (iv) waive any  conditions,  (v) modify or amend
the Security Agreement or the Subordination  Agreement (but not the Notes), (vi)
execute any  instrument  or document  that the Secured  Party may  determine  is
necessary  or  desirable  in the  exercise of its  authority  under this Section
11.14,  and  (vii) act in  connection  with all other  matters  relating  to the
Security  Agreement.  The Secured  Party shall be authorized to act on behalf of
the Purchasers as provided in the Security  Agreement,  and the Company shall be
entitled to act and rely upon any request,  notice, consent, waiver or agreement
given on behalf  of the  undersigned  when the same  shall  have  been  given by
Paramount  Capital,  Inc. on such behalf  pursuant to the terms of such Security
Agreement or this Agreement.  Paramount  Capital,  Inc. may act in reliance upon
the advice of counsel in reference to any matter  relating  hereto and shall not
be liable for any acts or omissions of any kind.

         11.15 Consent to Jurisdiction.  The parties hereto irrevocably  consent
to the  jurisdiction  of the courts of the State of New York and of any  federal
court located in such State in connection with any action or proceeding  arising
out of or relating to this  Agreement,  any  document  or  instrument  delivered
pursuant to, in connection  with or  simultaneously  with this  Agreement,  or a
breach of this Agreement or any such document or instrument.  In any such action
or  proceeding,  each party  hereto  waives  personal  service  of any  summons,
complaint  or other  process  and agrees  that  service  thereof  may be made in
accordance with Section 11.15.  Within 30 days after such service, or such other
time as may be mutually  agreed upon in writing by the attorneys for the parties
to such action or  proceeding,  the party so served  shall appear or answer such
summons, complaint or other process.


                                 Page 37 of 99 Pages


<PAGE>

         IN WITNESS WHEREOF,  the parties hereto have executed this Agreement as
of the day and year first above written.


                               GENTA INCORPORATED.


                               By: /s/ Thomas H. Adams
                                   ---------------------------
                                   Name: Dr. Thomas H. Adams
                                   Title:  President and Chief
                                           Executive Officer

                               THE ARIES FUND, A CAYMAN
                               ISLAND TRUST

                               By:  its Investment Manager,
                               PARAMOUNT CAPITAL ASSET
                               MANAGEMENT, INC.


                               By: /s/Lindsay A. Rosenwald
                                   ---------------------------------
                                   Name:  Lindsay A. Rosenwald, M.D.
                                   Title:  President


                               THE ARIES DOMESTIC FUND, L.P.


                               By:  its General Partner, PARAMOUNT
                               CAPITAL ASSET MANAGEMENT, INC..


                               By: /s/Lindsay A. Rosenwald
                                   ---------------------------------
                                   Name:  Lindsay A. Rosenwald, M.D.
                                   Title:  President


                              Page 38 of 99 Pages


<PAGE>


                                    EXHIBIT F

THIS NOTE IS NOT  TRANSFERABLE  WITHOUT  THE  EXPRESS  WRITTEN  CONSENT OF GENTA
INCORPORATED,  (THE "COMPANY"). THE SECURITIES REPRESENTED BY THIS NOTE HAVE NOT
BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF  1933 OR ANY  APPLICABLE  STATE
SECURITIES LAWS, AND MAY NOT BE SOLD,  OFFERED FOR SALE, PLEDGED OR HYPOTHECATED
OR OTHERWISE  TRANSFERRED IN THE ABSENCE OF A  REGISTRATION  STATEMENT IN EFFECT
WITH RESPECT TO THE  SECURITIES  UNDER SUCH ACT OR AN EXEMPTION  THEREFROM.  ANY
SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE STATE SECURITIES LAWS.


                               GENTA INCORPORATED

                                                                          No.B-1
                     SENIOR SECURED CONVERTIBLE BRIDGE NOTE

$1,050,000                                                    New York, New York
                                                              January 28, 1997

         Genta Incorporated, a Delaware corporation,  (the "Company"), for value
received,  hereby promises to pay to THE ARIES DOMESTIC FUND, LP (the "Holder"),
or registered  assigns,  the principal sum of ONE MILLION FIFTY THOUSAND DOLLARS
($1,050,000),  with  interest  from the date of issuance of this Senior  Secured
Convertible  Bridge  Note on the  unpaid  principal  balance  at a rate equal to
twelve percent (12%) per annum, on the earlier of (a) June 30, 1997 and (b) five
(5) business days following the  completion of any equity  offering or series of
equity  offerings  with gross  proceeds in excess of $2,500,000  (the  "Maturity
Date").  Payment  shall be made at such place as  designated  by the Holder upon
surrender of this Senior Secured  Convertible  Bridge Note, and shall be in such
coin or currency of the United States of America as at the time of payment shall
be legal tender for the payment of public and private  debts.  Interest shall be
computed on the basis of a 360-day  year of twelve  30-day  months.  This Senior
Secured  Convertible  Bridge  Note is one of a duly  authorized  issue  of Genta
Incorporated  12% Senior  Convertible  Bridge  Notes in an  aggregate  principal
amount of $3,000,000 (individually a "Note" and collectively the "Notes") issued
pursuant to a Note and Warrant Purchase  Agreement of even date herewith between
the  Company  and the Holder  (the  "Purchase  Agreement").  The Senior  Secured
Convertible  Bridge  Notes  shall be  senior to all  other  indebtedness  of the
Company ("Other  Indebtedness") and all Other Indebtedness shall be subordinated
to the Senior  Bridge  Notes.  These Notes are secured  pursuant to the Security
Agreement  dated as of January 28, 1997 by and  between the  Company,  Paramount
Capital, Inc. and the Purchasers.

SECTION 1. PREPAYMENT.

         This Note (including  interest accrued on the principal  hereof) may be
prepaid by the Company, at any time without penalty or premium provided that the
Company  shall  provide  the  holders  of the Notes  with at least 30 days prior
written notice of prepayment,  and prior to such prepayment,  the holders of the
Notes shall have the  opportunity to exercise their optional  conversion  rights
pursuant to Section 2 hereof.

SECTION 2. OPTIONAL CONVERSION

         (a) Right of Conversion. (i) Immediately,  or, (ii) if the rules of the
Nasdaq National  Market or any other law or regulation,  require the approval of
the shareholders of the Company to permit convertibility of the Notes, then upon
the receipt of such approvals,  the Notes shall be  convertible,  in whole or in
part, at the option of the holder thereof and upon notice to the  Corporation as
set  forth in  paragraph  2(b)  below,  into the  number  of  shares of Series D
Preferred Stock of the Company (the  "Preferred  Stock") equal to the Conversion
Amount  divided by the then current  Conversion  Price (as defined  below).  The
Conversion  Amount shall be the Liquidation  Amount, or in the case of a partial
conversion,  such lesser  amount as  designated by the  converting  holder.  The
Liquidation  Amount shall be the aggregate  principal value of the Notes held by
such Holder plus any accrued and unpaid  interest.  The  Conversion  Price shall
initially be $5.00,  subject to adjustment as provided  below,  representing  an
initial  conversion  rate  (subject to  adjustment)  of 2000 shares of Preferred
Stock per $10,000 of Conversion Amount.


                              Page 39 of 99 Pages


<PAGE>

         (b) Conversion Procedures. Any holder of Notes desiring to convert such
Notes into  Preferred  Stock  shall  surrender  the Notes at the  offices of the
Company,  which Notes shall be accompanied by irrevocable  written notice to the
Corporation  that the holder elects so to convert such Notes and  specifying the
name or names (with address) in which a certificate or  certificates  evidencing
shares of Preferred Stock are to be issued. The Corporation will make a notation
of the date that a notice of conversion is received,  which date shall be deemed
to be the date of receipt for purposes hereof.

         The Corporation shall deliver to the holder converting the Notes, or to
the nominee or nominees of such person,  certificates  evidencing  the number of
full  shares of  Preferred  Stock to which  such  person  shall be  entitled  as
aforesaid,  together  with a cash  adjustment  of any  fraction  of a  share  as
hereinafter  provided.  Subject to the following  provisions of this  paragraph,
such  conversion  shall  be  deemed  to have  been  made as of the  date of such
surrender  of the Notes and the  person  or  persons  entitled  to  receive  the
Preferred Stock  deliverable  upon conversion of such Notes shall be treated for
all  purposes as the record  holder or holders of such  Preferred  Stock on such
date; provided,  however,  that the Corporation shall not be required to convert
any Notes while the stock transfer books of the  Corporation  are closed for any
purpose,  but the surrender of Notes for conversion during any period while such
books are so closed shall become  effective for conversion  immediately upon the
reopening  of such books as if the  surrender  had been made on the date of such
reopening,  and the conversion shall be at the conversion rate in effect on such
date.

         All notices of conversion shall be irrevocable; provided, however, that
if the  Corporation  has sent  notice of an event  pursuant  to  paragraph  2(e)
hereof,  a holder  of Notes  may,  at its  election,  provide  in its  notice of
conversion  that  the  conversion  of its  Notes  shall be  contingent  upon the
occurrence  of the record date or  effectiveness  of such event (as specified by
such  holder),  provided  that such  notice of  conversion  is  received  by the
Corporation prior to such record date or effective date, as the case may be.

         (c) Protection From Dilution.  (i) If, at any time or from time to time
after the date of this  Note,  the  Company  shall  issue or  distribute  to the
holders of shares of Preferred  Stock  evidence of its  indebtedness,  any other
securities  of the Company or any cash,  property or other  assets  (excluding a
subdivision,  combination  or  reclassification,  or  dividend  or  distribution
payable  solely to  holders of  Preferred  Stock in shares of  Preferred  Stock,
referred to in Subsection  (c)(ii),  and also  excluding  cash dividends or cash
distributions  paid out of net profits  legally  available  therefor in the full
amount  thereof  (any such  non-excluded  event being  herein  called a "SPECIAL
DIVIDEND"), the Conversion Price shall be adjusted by multiplying the Conversion
Price then in effect by a  fraction,  the  numerator  of which shall be the then
Current  Market Price Per Share of Preferred  Stock in effect on the record date
of such issuance or  distribution  less the fair market value (as  determined in
good faith by the Company's Board of Directors) of the evidence of indebtedness,
cash,  securities  or property,  or other assets issued or  distributed  in such
Special Dividend  applicable to one share of Preferred Stock and the denominator
of which shall be the then Current Market Price Per Share of Preferred  Stock in
effect on the record date of such issuance or  distribution.  An adjustment made
pursuant to this Subsection 2(a) shall become  effective  immediately  after the
record date of any such Special  Dividend.  The then  "CURRENT  MARKET PRICE PER
SHARE OF PREFERRED  STOCK" shall equal the then Current Market Price  multiplied
by the then effective  "conversion rate" (as defined and used in the Certificate
of Designation for the Series D Preferred Stock).

The then Current  Market Price per share (the "CURRENT  MARKET  PRICE") shall be
deemed to be the last sale price of the Common Stock on the trading day prior to
such date or, in case no such reported sales take place on such day, the average
of the last  reported  bid and asked  prices of the Common Stock on such day, in
either case on the principal  national  securities  exchange on which the Common
Stock is admitted to trading or listed,  or if not listed or admitted to trading
on any such exchange,  the representative  closing bid price of the Common Stock
as reported by the National  Association of Securities  Dealers,  Inc. Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined in good faith by the Board of Directors.

         (ii) In case the Company  shall  hereafter (i) pay a dividend or make a
distribution on its capital stock in shares of Preferred  Stock,  (ii) subdivide
its outstanding shares of Preferred Stock into a greater number of shares, (iii)
combine  its  outstanding  shares of  Preferred  Stock into a smaller  number of
shares or (iv) issue by  


                              Page 40 of 99 Pages
<PAGE>

reclassification  of its  Preferred  Stock any  shares of  capital  stock of the
Company  (other  than the  Conversion  Shares),  the  Conversion  Price shall be
proportionately  adjusted so that the Notes shall be  convertible  into a number
and kind of  securities  which the holders  would have been  entitled to receive
after any such event had they converted the Notes immediately prior thereto.  An
adjustment  made pursuant to this  Subsection  2(c)(ii)  shall become  effective
immediately  after the record date in the case of a dividend or distribution and
shall become  effective  immediately  after the effective  date in the case of a
subdivision, combination or reclassification.

         (iii) Except as provided in Subsections (c)(i) and (c)(iv), in case the
Company  shall  hereafter  issue or sell any  Preferred  Stock,  any  securities
convertible into Preferred  Stock,  any rights,  options or warrants to purchase
Preferred Stock or any securities convertible into Preferred Stock, in each case
for a price per share or  entitling  the holders  thereof to purchase  Preferred
Stock at a price per share (determined by dividing (i) the total amount, if any,
received or receivable by the Company in  consideration  of the issuance or sale
of such securities plus the total consideration,  if any, payable to the Company
upon  exercise or  conversion  thereof (the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of  Preferred  Stock  issuable  upon  exercise  or
conversion of such securities) which is less than either the then Current Market
Price Per Share of  Preferred  Stock in effect on the date of such  issuance  or
sale or the Conversion  Price,  the Conversion Price shall be adjusted as of the
date of such issuance or sale by multiplying the Conversion Price then in effect
by a fraction,  the numerator of which shall be (x) the sum of (A) the number of
shares of Preferred  Stock  outstanding  on the record date of such  issuance or
sale plus (B) the Total  Consideration  divided by the Current  Market Price Per
Share of Preferred Stock or the current Conversion Price,  whichever is greater,
and the  denominator  of which  shall be (y) the  number of shares of  Preferred
Stock  outstanding  on the record date of such issuance or sale plus the maximum
number of additional  shares of Preferred  Stock  issued,  sold or issuable upon
exercise or conversion of such securities.

         (iv) In case of any capital reorganization or reclassification,  or any
consolidation  or merger to which the  Company is a party other than a merger or
consolidation in which the Company is the continuing corporation,  or in case of
any sale or  conveyance  to another  entity of the property of the Company as an
entirety  or  substantially  as a  entirety,  or in the  case  of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Note shall have the right  thereafter  to receive on the  conversion  of
this Note the kind and amount of  securities,  cash or other  property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had  this  Note  been  converted  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 2 with respect to the rights and  interests  thereafter of
the Holder of this Note to the end that the provisions set forth in this Section
2  shall  thereafter  correspondingly  be  made  applicable,  as  nearly  as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  Note.  The above  provisions  of this
Subsection   (c)(iv)  shall  similarly  apply  to  successive   reorganizations,
reclassifications,   consolidations,  mergers,  statutory  exchanges,  sales  or
conveyances.  The  Company  shall  require  the issuer of any shares of stock or
other securities or property thereafter deliverable on the exercise of this Note
to be  responsible  for all of the  agreements  and  obligations  of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the Notes not less than
30 days prior to such event. A sale of all or substantially all of the assets of
the Company for a  consideration  consisting  primarily of  securities  shall be
deemed a consolidation or merger for the foregoing purposes.

         (v) In case any event shall occur as to which the other  provisions  of
this Section 2 are not strictly  applicable  but as to which the failure to make
any adjustment  would not fairly protect the  conversion  rights  represented by
this Note in accordance with the essential intent and principles hereof then, in
each such case,  the Holders of Notes may appoint a firm of  independent  public
accountants  of  recognized  national  standing  reasonably  acceptable  to  the
Company, which shall give their opinion as to the adjustment, if any, on a basis
consistent  with  the  essential  intent  and  principles   established  herein,
necessary to preserve the conversion rights.  Upon receipt of such opinion,  the
Company will  promptly  mail a copy thereof to the Holder of this Note and shall
make  the  adjustments   described  therein.  The  fees  and  expenses  of  such
independent public accountants shall be borne by the Company.

         
                              Page 41 of 99 Pages
<PAGE>

(vi) For purposes of the anti-dilution protection contained in this Section (c),
at all times  following  the  conversion  of all shares of Preferred  Stock into
shares of Common  Stock,  the term  Preferred  Stock  shall be read to be Common
Stock, context permitting, so that the anti-dilution provisions will continue to
protect the conversion  rights  represented by this Note after the conversion of
all the Preferred  Stock into the Common Stock in accordance  with the essential
intent and principles of this Section 3 (it being  understood that prior to such
conversion,  the anti-dilution provisions of the Preferred Stock underlying this
Note shall be applicable to any dilutive events with respect to the Common Stock
and protect the Holder from dilution of the Common Stock).

         (d) Reservation of Shares;  Transfer Taxes;  Etc. The Corporation shall
at all times  reserve and keep  available,  out of its  authorized  and unissued
shares of Preferred Stock, solely for the purpose of effecting the conversion of
the Notes,  such  number of shares of its  Preferred  Stock  free of  preemptive
rights as shall be sufficient to effect the conversion of all Notes from time to
time outstanding.  The Corporation shall use its best efforts from time to time,
in accordance with the laws of the State of Delaware, to increase the authorized
number  of  shares  of  Preferred  Stock if at any time the  number of shares of
Preferred Stock not outstanding shall not be sufficient to permit the conversion
of all the then-outstanding Notes.

         The Corporation  shall pay any and all issue or other taxes that may be
payable in  respect of any issue or  delivery  of shares of  Preferred  Stock on
conversion of the Notes. The Corporation shall not, however,  be required to pay
any tax which may be payable in respect of any transfer involved in the issue or
delivery of Preferred Stock (or other securities or assets) in a name other than
that in which the  Notes so  converted  were  registered,  and no such  issue or
delivery  shall be made  unless and until the person  requesting  such issue has
paid to the  Corporation  the  amount  of such  tax or has  established,  to the
satisfaction of the Corporation, that such tax has been paid.

         (e) Prior Notice of Certain Events. In case:

               (i) the  Corporation  shall  declare any  dividend  (or any other
               distribution); or

               (ii) the Corporation  shall authorize the granting to the holders
               of  Preferred  Stock of rights or  warrants to  subscribe  for or
               purchase  any shares of stock of any class or of any other rights
               or warrants; or

               (iii) of any  reclassification  of Preferred  Stock (other than a
               subdivision or combination of the outstanding Preferred Stock, or
               a change in par value, or from par value to no par value, or from
               no par value to par value); or

               (iv) of any consolidation or merger to which the Corporation is a
               party  and  for  which  approval  of  any   stockholders  of  the
               Corporation shall be required,  or of the sale or transfer of all
               or  substantially  all of the assets of the Corporation or of any
               compulsory   share  exchange   whereby  the  Preferred  Stock  is
               converted into other securities, cash or other property; or

               (v) of the voluntary or involuntary  dissolution,  liquidation or
               winding up of the Corporation;

then the Corporation  shall cause to be mailed to the holders of Notes, at their
last addresses as they shall appear upon the books of the Corporation,  at least
20 days prior to the  applicable  record date  hereinafter  specified,  a notice
stating  (x) the date on which a record (if any) is to be taken for the  purpose
of such dividend, distribution or granting of rights or warrants or, if a record
is not to be  taken,  the date as of which the  holders  of  Preferred  Stock of
record to be entitled to such dividend, distribution,  rights or warrants are to
be determined and a description of the cash,  securities or other property to be
received by such holders upon such dividend,  distribution or granting of rights
or  warrants  or (y) the date on  which  such  reclassification,  consolidation,
merger, sale, transfer, share exchange,  dissolution,  liquidation or winding up
or other liquidation event is expected to become effective, the date as of which
it is expected  that holders of  Preferred  Stock of record shall be entitled to
exchange  their  shares of  Preferred  Stock for  securities  or other  property
deliverable upon such exchange, dissolution,  liquidation or winding up or other
liquidation event and the consideration, including securities or other property,
to be received by such holders upon such exchange;  provided,  however,  that no
failure to mail such


                              Page 42 of 99 Pages


<PAGE>

notice or any defect therein or in the mailing thereof shall affect the validity
of the corporate action required to be specified in such notice.

         (f) Other Changes in Conversion Rate. The Corporation from time to time
may  increase  the  Conversion  Rate by any amount for any period of time if the
period is at least 20 days and if the increase is irrevocable during the period.
Whenever the  Conversion  Rate is so increased,  the  Corporation  shall mail to
holders of record of Notes a notice of the  increase at least 15 days before the
date the increased Conversion Rate takes effect, and such notice shall state the
increased Conversion Rate and the period it will be in effect.

         The  Corporation  may make such  increases in the  Conversion  Rate, in
addition  to  those  required  or  allowed  by this  paragraph  4, as  shall  be
determined by it, as evidenced by a resolution of the Board of Directors,  to be
advisable  in order to avoid or  diminish  any  income  tax to holders of Common
Stock resulting from any dividend or distribution of stock or issuance of rights
or warrants to purchase or subscribe for stock or from any event treated as such
for income tax purposes.

SECTION 3. DEFAULT CONVERSION.

         (a) If this Note and all accrued  interest  shall not have been paid in
full on or  before  the  Maturity  Date or upon  the  occurrence  of an Event of
Default (as defined in Section 7 hereof),  the Holder  shall have the right (the
"Default  Conversion  Right"),  in addition to any other available  remedies set
forth in Section 8 hereof or at law or in equity, to convert up to the lesser of
(i) the  then  outstanding  principal  amount  of this  Note or (ii)  10% of the
original  principal  amount of this  Note,  into the  number of shares of Common
Stock of the Company  ("Common  Stock"),  equal to the amount  converted  by the
Noteholder upon such Event of Default (the "Default  Conversion Amount") divided
by $.001 (the "Default  Conversion Price").  Upon conversion,  the Company shall
pay all accrued and unpaid interest on the Default Conversion Amount.

         (b) To exercise the Default  Conversion Right, the Holder, on or before
the 60th day after the  Maturity  Date,  but before  payment in full of the then
outstanding  principal  and  interest  under  this  Note,  shall  deliver to the
Company,  at its office at as set forth in section 11, or at such other place as
is  designated  in writing by the Company,  a notice (the  "Conversion  Notice")
stating that the Holder is exercising the Default  Conversion Right, the Default
Conversion  Amount  and the  name or  names  in  which  the  Holder  wishes  the
certificates for shares of Common Stock to be issued.

         (c) To the extent  permitted by  applicable  law,  upon exercise of the
Default  Conversion Right, the Holder shall be deemed to be the holder of record
of the shares of Common  Stock  issuable  upon such  exercise  (the  "Conversion
Shares"),  notwithstanding  that the transfer books of the Company shall then be
closed or certificates  representing  such Conversion Shares shall not then have
been actually  delivered to the Holder.  As soon as practicable and in any event
within five (5) days after exercise of the Default Conversion Right, the Company
shall issue and deliver to the Holder a certificate or  certificates  evidencing
the  Conversion  Shares  registered  in the name of the Holder or its  designee,
provided that the Company may require the holder,  by notice given to the Holder
promptly after receipt of the Conversion  Notice, as a condition to the delivery
of such certificate or certificates, to present this Note to the Company for the
placement  hereon of a legend  indicating that the Default  Conversion Right has
been  exercised to the extent of the Default  Conversion  Amount,  and this Note
(unless thereby paid in full) shall be immediately returned to the Holder.

         (d) The issuance of any shares or other securities upon the exercise of
the  Default  Conversion  Right,  and the  delivery  of  certificates  or  other
instruments representing such shares or other securities,  shall be made without
charge to the  Holder for any tax or other  charge in respect of such  issuance.
The Company shall not, however,  be required to pay any tax which may be payable
in respect of any transfer involved in the issue and delivery of any certificate
in a name other than that of the Holder and the Company shall not be required to
issue or  deliver  any such  certificate  unless and until the person or persons
requesting  the issue  thereof shall have paid to the Company the amount of such
tax or shall have  established to the  satisfaction of the Company that such tax
has been paid.

         (e) The Holder  shall not have,  solely on account of such  status as a
Holder of this Note, any rights of a stockholder  of the Company,  either at law
or in  equity,  or any  notice  of  meetings  of  stockholders  or of any  other
proceedings of the Company except as provided in this Note.


                              Page 43 of 99 Pages
<PAGE>

         (f) The Company shall at all times following the Issuance Date, reserve
and keep available out of its  authorized  and unissued  shares of Common Stock,
solely for the purpose of providing  for the exercise of the Default  Conversion
Right,  such number of shares of Common  Stock as shall,  from time to time,  be
sufficient for the exercise of the Default Conversion Right in full. The Company
covenants  that all shares of Common Stock issuable upon exercise of the Default
Conversion Right shall be validly issued, fully paid and nonassessable.

         (g) The  anti-dilution  protections  set forth in Section  2(c)  hereof
shall apply as well to the Default  Conversion  Right and the  adjustment of the
Default Conversion Price hereunder, provided, however, that for purposes of such
application  all  appropriate  references  to  Preferred  Stock shall be read as
references to Common Stock and all references to the  Conversion  Price shall be
read as references to the Default  Conversion  Price,  so as to give the Default
Conversion  Rights,  as  nearly  as  practicable,  the  anti-dilution  and other
protections provided for in section 2(c) with respect to the Optional Conversion
Right.

SECTION 4. FRACTIONAL SHARES.

         (a) The Company  shall not be required to issue  fractions of shares of
Common  Stock or other  capital  stock of the Company  upon the  exercise of the
Optional  and  Default  Conversion  Right.  If any  fraction of a share would be
issuable  on any  exercise  of the  Optional  or  Default  Conversion  Right (or
specified  portions  thereof),  the Company shall  purchase such fraction for an
amount in cash equal to the same  fraction of the  closing  price for the Common
Stock on the  trading  date  immediately  preceding  the date of exercise of the
Optional or Default Conversion Right.


SECTION 5. AFFIRMATIVE COVENANTS OF THE COMPANY.

         The Company covenants and agrees that until the payment in full of this
Note, the Company shall:

         (a) Existence; Business. (i) Preserve, renew and keep in full force and
effect its legal existence and (ii) obtain, preserve,  renew, extend and keep in
full force and effect the licenses, permits, authorizations, patents, trademarks
and trade names material to its business.

         (b) Use of Proceeds. Use the proceeds of the Notes of this issue solely
as set forth in Section 7.7 of the Note and Warrant Purchase  Agreement  between
the  Company  and  various  purchasers  dated  the date  hereof  (the  "Purchase
Agreement")

         (c)  Reports.  Furnish  to the  Holder,  at the time  furnished  to the
Company's   stockholders,   reports   furnished   generally  to  the   Company's
stockholders, and copies of Current Reports on Form 8-K.

         (d) Notice of Events of Default.  Furnish to the Holder prompt  written
notice of any Event of  Default,  specifying  the nature and extent  thereof and
corrective action, if any, proposed to be taken with respect thereto.

         (e) Authorization of Stock Issuable Upon Conversion.  No later than the
Maturity  Date,  authorize  and  reserve a  sufficient  number of its shares for
exercise of the Default Conversion Right.


SECTION 6. NEGATIVE COVENANTS OF THE COMPANY.

         The Company covenants and agrees with the Holder that until the payment
in full of this Note, the Company shall not:

         (a)  Indebtedness.  Incur,  create,  assume  or  permit  to  exist  any
indebtedness except (i) indebtedness represented by the Notes, (ii) indebtedness
which by its terms is  subordinated  to the Notes in an amount less than $25,000
in the  aggregate  (iii)  indebtedness  in an amount  less than  fifty  thousand
dollars ($50,000) incurred in the ordinary course of business, and (iv)
indebtedness  for borrowed  money  existing on the date hereof and  disclosed in
writing to the Holder on or prior to the date  hereof,  but not any  extensions,
renewals or replacements of such indebtedness;


                              Page 44 of 99 Pages


<PAGE>

         (b)  Liens.  Create,  incur,  assume or permit to exist any lien on any
property or assets (including stock or other securities of any person) now owned
or hereafter acquired by the Company,  except (i) liens for taxes not yet due or
which  are  being   contested  by  appropriate   proceedings;   (ii)  carriers',
warehousemen's,  mechanic's,  materialmen's,  repairmen's  or other  like  liens
arising in the ordinary course of business and securing obligations that are not
due or which are being  contested;  or (iii) liens of attachments,  judgments or
awards against the Company (X) which could not reasonably be expected to have an
adverse material effect on the Company or (Y) with respect to which an appeal or
proceeding  for review shall be pending or a stay of  execution  shall have been
obtained,  or  which  are  otherwise  being  contested  in  good  faith  and  by
appropriate  proceedings,  or (iv) purchase  money liens,  equipment  leases and
financings incurred in the ordinary course of business.

         (c) Sale  and  Lease-Back  Transactions.  Enter  into any  arrangement,
directly or  indirectly,  with any person  whereby it shall sell or transfer any
property, real or personal, used or useful in its business, whether now owned or
hereafter acquired, and thereafter rent (including intellectual property), lease
or  license  such  property  or  other  property  which  it  intends  to use for
substantially  the same  purpose  or  purposes  as the  property  being  sold or
transferred.

         (d) Mergers,  Consolidations,  Sales of Assets and Acquisitions.  Merge
into or consolidate  with any other person,  or permit any other person to merge
into or consolidate with it, or sell,  transfer,  lease or otherwise  dispose of
(in one transaction or in a series of transactions) all or a substantial part of
its assets  (whether  now owned or hereafter  acquired)  or  purchase,  lease or
otherwise  acquire (in one  transaction  or a series of  transactions)  all or a
substantial part of the assets of any other person.

         (e)  Dividends  and   Distributions.   Declare  or  pay,   directly  or
indirectly, any dividend or make any other distribution (by reduction of capital
or otherwise),  whether in cash, property,  securities or a combination thereof,
with  respect to any  shares of its  capital  stock or  directly  or  indirectly
redeem, purchase,  retire or otherwise acquire for value any shares of any class
of its  capital  stock or set aside any amount for any such  purpose,  except as
permitted by Section 7.15 of the Note and Warrant Agreement.

         (f)  No   Impairment.   By   amendment   of  its   charter  or  through
reorganization,  consolidation, merger, dissolution, sale of assets or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the  terms of this  Note,  but will at all  times in good  faith  assist  in the
carrying  out of all such terms and in the  taking of all such  action as may be
necessary  or  appropriate  in order to protect the rights of the Holder of this
Note against impairment.


SECTION 7. EVENTS OF DEFAULT DEFINED.

         The following shall each constitute an "Event of Default" hereunder:

         (a) the failure of the Company to make any payment of  principal  of or
interest on this Note when due and payable;

         (b) the failure of the  Company to observe or perform  any  covenant in
this Note or in the Purchase  Agreement,  and such failure shall have  continued
unremedied for a period of five (5) days;

         (c) if the Company shall:

               (1) admit in writing its inability to pay its debts  generally as
               they become due,

               (2) file a petition in bankruptcy or a petition to take advantage
               of any insolvency act,

               (3) make an assignment for the benefit of its creditors,

               (4) consent to the  appointment of a receiver of itself or of the
               whole or any substantial part of its property,


                              Page 45 of 99 Pages


<PAGE>

               (5) on a petition in bankruptcy  filed against,  be adjudicated a
               bankrupt, or

               (6)  file  a  petition  or  answer  seeking   reorganization   or
               arrangement  under  the  federal  bankruptcy  laws  or any  other
               applicable  law or statute of the United States of America or any
               state thereof;

         (d) if a court of competent jurisdiction shall enter an order, judgment
or decree  appointing,  without  the consent of the  Company,  a receiver of the
Company or of the whole or any substantial part of its property,  or approving a
petition filed against it seeking  reorganization  or arrangement of the Company
under the federal  bankruptcy laws or any other applicable law or statute of the
United  States of America or any State  thereof,  and such  order,  judgment  or
decree shall not be vacated or set aside or stayed  within thirty (30) days from
the date of entry thereof;

         (e) if, under the  provisions of any other law for the relief or aid of
debtors, any court of competent  jurisdiction shall assume custody or control of
the  Company  or the  whole or any  substantial  part of its  property  and such
custody or control  shall not be  terminated  or stayed  within thirty (30) days
from the date of assumption of such custody or control;

         (f) the liquidation, dissolution or winding up of the Company;

         (g) the  failure of the  shareholders  to  authorize  and  approve  the
issuance  of these  Notes or the  issuance  of the shares of Series D  Preferred
Stock  underlying  these Notes, the Bridge Warrants or the New Warrants (as such
terms are defined in the Purchase Agreement), or any Common Stock underlying the
foregoing to the extent such authorization is necessary pursuant to the rules of
the Nasdaq National Market or any other applicable law, rule or regulation.

         (h) A default or event of default which remains  uncured  following any
applicable cure period under the Security Agreement; or

         (i) A final judgment or judgments for the payment of money in excess of
$1,000,000  in  the  aggregate   shall  be  rendered  by  one  or  more  courts,
administrative or arbitral tribunals or other bodies having jurisdiction against
the Company and the same shall not be discharged (or provision shall not be made
for such  discharge),  or a stay of  execution  thereof  shall not be  procured,
within 30 days from the date of entry thereof and the Company shall not,  within
such 30-day  period,  or such longer period  during which  execution of the same
shall have been stayed,  appeal therefrom and cause the execution  thereof to be
stayed during such appeal; or


SECTION 8. REMEDIES UPON EVENT OF DEFAULT.

         (a)  Upon  the  occurrence  of an  Event  of  Default,  (i) the  entire
principal  amount of, and all  accrued and unpaid  interest  on, this Note shall
automatically  become immediately due and payable without  presentment,  demand,
protest or other  formalities  of any kind,  all of which are  hereby  expressly
waived by the Company and (ii)  additional  interest shall begin to accrue,  and
shall be considered  immediately due and payable, on the unpaid principal amount
of this Note at the rate of eighteen  percent (18%) per annum and shall continue
to accrue  until the  initial  interest  and  additional  interest  is paid.  In
addition,  the  Holder may take any action  available  to it under the  Purchase
Agreement or at law or in equity or by statute or otherwise.

         (b) No remedy herein conferred upon the Holder of this Note is intended
to be  exclusive  of any other  remedy and each and every such  remedy  shall be
cumulative and shall be in addition to every other remedy given hereunder or now
or hereafter existing at law or in equity or by statute or otherwise.


SECTION 9. NOTE REGISTER.

         (a) The Company shall keep at its principal executive office a register
(herein sometimes referred to as the "Note Register"), in which, subject to such
reasonable  regulations  as it may  prescribe,  but at its  expense  (other than
transfer  taxes,  if any),  the Company shall provide for the  registration  and
transfer of this Note.


                              Page 46 of 99 Pages


<PAGE>

         (b) Whenever this Note shall be surrendered at the principal  executive
office  of the  Company  for  transfer  or  exchange,  accompanied  by a written
instrument  of  transfer in form  reasonably  satisfactory  to the Company  duly
executed by the Holder  hereof or his attorney duly  authorized in writing,  the
Company shall execute and deliver in exchange  therefor a new Note or Notes,  as
may be requested by such Holder,  in the same aggregate  unpaid principal amount
and  payable  on the same date as the  principal  amount of the Note or Notes so
surrendered;  each such new Note shall be dated as of the date to which interest
has been paid on the unpaid principal amount of the Note or Notes so surrendered
and shall be in such  principal  amount and  registered in such name or names as
such Holder may designate in writing.

         (c) Upon receipt by the Company of evidence reasonably  satisfactory to
it of the loss,  theft,  destruction or mutilation of this Note and of indemnity
reasonably  satisfactory  to it, and upon  reimbursement  to the  Company of all
reasonable expenses  incidental thereto,  and upon surrender and cancellation of
this Note (in case of  mutilation)  the Company will make and deliver in lieu of
this Note a new Note of like tenor and unpaid  principal  amount and dated as of
the date to which interest has been paid on the unpaid  principal amount of this
Note in lieu of which such new Note is made and delivered.


SECTION 10. REGISTRATION UNDER SECURITIES ACT OF 1933.

         The Holder of this Note shall have  registration  rights as provided in
Section 8 of the Purchase Agreement,  with respect to the shares of Common Stock
underlying the Series D Preferred  Stock  issuable upon  conversion of the Notes
pursuant to the Optional and Default  Conversion  Right.  If the Holder is not a
party to the Purchase  Agreement,  by acceptance of this Note, the Holder agrees
to comply with  provisions  of Section 8 of the  Purchase  Agreement to the same
extent as if it were a party thereto.


SECTION 11. MISCELLANEOUS.

         (a)  Amendments  and Waivers.  The holders of sixty-six and  two-thirds
percent (66 2/3%) or more in principal amount of outstanding Notes of this issue
may waive or otherwise consent to the amendment of any of the provisions hereof,
provided that no such waiver or amendment may reduce the principal  amount of or
interest on any of the Notes of this issue or change the stated  maturity of the
principal or reduce the  percentage of holders of Notes of this issue  necessary
to waive or amend the  provisions  of this  Note,  without  the  consent of each
holder of any Note affected thereby.

         (b)  Restrictions on  Transferability.  In addition to the restrictions
set forth in Section 9(a) of this Note, the securities  represented by this Note
have  been  acquired  for  investment  and have not been  registered  under  the
Securities Act of 1933, as amended, or the securities laws of any state or other
jurisdiction.  Without  such  registration,  such  securities  may not be  sold,
pledged,  hypothecated or otherwise  transferred,  except pursuant to exemptions
from the Securities  Act of 1933, and the securities  laws of any state or other
jurisdiction.  Notwithstanding  the  above,  the  holder  of this  Note has been
provided  the  registration  rights  contained  in  Section  8 of  the  Purchase
Agreement with respect to the shares of the Company's  Common Stock which may be
acquired upon exercise of the Optional and Default Conversion Right.

         (c)  Forbearance  from  Suit.  No holder of Notes of this  issue  shall
institute any suit or proceeding for the enforcement of the payment of principal
or interest unless the holders of at least fifty-one  percent (51%) in principal
amount  of all of the  outstanding  Notes  of this  issue  join in such  suit or
proceeding.

         (d)  Governing  Law.  This Note shall be governed by and  construed  in
accordance  with the laws of the  State of New York,  excluding  the body of law
relating to conflict of laws. Notwithstanding anything to the contrary contained
herein, in no event may the effective rate of interest  collected or received by
the Holder exceed that which may be charged, collected or received by the Holder
under applicable law.


                              Page 47 of 99 Pages


<PAGE>

         (e) Interpretation. If any term or provision of this Note shall be held
invalid,  illegal  or  unenforceable,  the  validity  of  all  other  terms  and
provisions hereof shall in no way be affected thereby.

         (f) Successors and Assigns. This Note shall be binding upon the Company
and its  successors and assigns and shall inure to the benefit of the Holder and
its successors and assigns.

         (g) Notices. All notices, requests,  consents and demands shall be made
in writing and shall be mailed  postage  prepaid,  or delivered by hand,  to the
Company or to the Holder thereof at their  respective  addresses set forth below
or to such other  address  as may be  furnished  in  writing to the other  party
hereto:

                  If to the Holder:         At the address shown on Schedule A 
                                            attached hereto.

                  with a copy to:           Paramount Capital, Inc.
                                            787 Seventh Avenue
                                            New York, NY  10019
                                            Attn: David R. Walner

                  If to the Company:        Genta Incorporated
                                            3350 General Atomics Court
                                            San Diego, CA 92121
                                            Attention: Chief Executive Officer

         (h) Saturdays,  Sundays,  Holidays. If any date that may at any time be
specified  in this Note as a date for the making of any payment of  principal or
interest under this Note shall fall on Saturday, Sunday or on a day which in New
York  shall be a legal  holiday,  then the date for the  making of that  payment
shall be the  next  subsequent  day  which is not a  Saturday,  Sunday  or legal
holiday.

         (i) Purchase Agreement.  This Note is subject to the terms contained in
the  Purchase  Agreement  dated the date hereof  between the Company and certain
purchasers of the Senior Secured Convertible Bridge Notes and the holder of this
Note is entitled to the benefits of such Purchase Agreement and may, in addition
to any rights hereunder, enforce the agreements of the Company contained therein
and exercise the remedies provided for thereby or otherwise available in respect
thereof.


                                 Page 48 of 99 Pages


<PAGE>

         IN WITNESS  WHEREOF,  this Note has been  executed  and  delivered as a
sealed  instrument  on the date  first  above  written  by the  duly  authorized
representative of the Company.


ATTEST:                               GENTA INCORPORATED


                                      By: /s/ Thomas H. Adams
- -----------------------                   -----------------------
                                      Name: Dr. Thomas H. Adams
                                      Its: President and Chief Executive Officer



(Corporate Seal)


                                 Page 49 of 99 Pages


<PAGE>


                                    EXHIBIT G

THIS NOTE IS NOT  TRANSFERABLE  WITHOUT  THE  EXPRESS  WRITTEN  CONSENT OF GENTA
INCORPORATED,  (THE "COMPANY"). THE SECURITIES REPRESENTED BY THIS NOTE HAVE NOT
BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF  1933 OR ANY  APPLICABLE  STATE
SECURITIES LAWS, AND MAY NOT BE SOLD,  OFFERED FOR SALE, PLEDGED OR HYPOTHECATED
OR OTHERWISE  TRANSFERRED IN THE ABSENCE OF A  REGISTRATION  STATEMENT IN EFFECT
WITH RESPECT TO THE  SECURITIES  UNDER SUCH ACT OR AN EXEMPTION  THEREFROM.  ANY
SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE STATE SECURITIES LAWS.


                               GENTA INCORPORATED

                                                                          No.B-2
                     SENIOR SECURED CONVERTIBLE BRIDGE NOTE

$1,950,000                                                    New York, New York
                                                              January 28, 1997

         Genta Incorporated, a Delaware corporation,  (the "Company"), for value
received,  hereby  promises  to  pay to  THE  ARIES  TRUST  (the  "Holder"),  or
registered assigns, the principal sum of ONE MILLION NINE HUNDRED FIFTY THOUSAND
DOLLARS  ($1,950,000),  with  interest  from the date of issuance of this Senior
Secured  Convertible Bridge Note on the unpaid principal balance at a rate equal
to twelve  percent (12%) per annum,  on the earlier of (a) June 30, 1997 and (b)
five (5) business days following the completion of any equity offering or series
of equity  offerings with gross proceeds in excess of $2,500,000  (the "Maturity
Date").  Payment  shall be made at such place as  designated  by the Holder upon
surrender of this Senior Secured  Convertible  Bridge Note, and shall be in such
coin or currency of the United States of America as at the time of payment shall
be legal tender for the payment of public and private  debts.  Interest shall be
computed on the basis of a 360-day  year of twelve  30-day  months.  This Senior
Secured  Convertible  Bridge  Note is one of a duly  authorized  issue  of Genta
Incorporated  12% Senior  Convertible  Bridge  Notes in an  aggregate  principal
amount of $3,000,000 (individually a "Note" and collectively the "Notes") issued
pursuant to a Note and Warrant Purchase  Agreement of even date herewith between
the  Company  and the Holder  (the  "Purchase  Agreement").  The Senior  Secured
Convertible  Bridge  Notes  shall be  senior to all  other  indebtedness  of the
Company ("Other  Indebtedness") and all Other Indebtedness shall be subordinated
to the Senior  Bridge  Notes.  These Notes are secured  pursuant to the Security
Agreement  dated as of January 28, 1997 by and  between the  Company,  Paramount
Capital, Inc. and the Purchasers.

SECTION 1. PREPAYMENT.

         This Note (including  interest accrued on the principal  hereof) may be
prepaid by the Company, at any time without penalty or premium provided that the
Company  shall  provide  the  holders  of the Notes  with at least 30 days prior
written notice of prepayment,  and prior to such prepayment,  the holders of the
Notes shall have the  opportunity to exercise their optional  conversion  rights
pursuant to Section 2 hereof.

SECTION 2. OPTIONAL CONVERSION

         (a) Right of Conversion. (i) Immediately,  or, (ii) if the rules of the
Nasdaq National  Market or any other law or regulation,  require the approval of
the shareholders of the Company to permit convertibility of the Notes, then upon
the receipt of such approvals,  the Notes shall be  convertible,  in whole or in
part, at the option of the holder thereof and upon notice to the  Corporation as
set  forth in  paragraph  2(b)  below,  into the  number  of  shares of Series D
Preferred Stock of the Company (the  "Preferred  Stock") equal to the Conversion
Amount  divided by the then current  Conversion  Price (as defined  below).  The
Conversion  Amount shall be the Liquidation  Amount, or in the case of a partial
conversion,  such lesser  amount as  designated by the  converting  holder.  The
Liquidation  Amount shall be the aggregate  principal value of the Notes held by
such Holder plus any accrued and unpaid  interest.  The  Conversion  Price shall
initially be $5.00,  subject to adjustment as provided  below,  representing  an
initial  conversion  rate  (subject to  adjustment)  of 2000 shares of Preferred
Stock per $10,000 of Conversion Amount.


                              Page 50 of 100 Pages


<PAGE>

         (b) Conversion Procedures. Any holder of Notes desiring to convert such
Notes into  Preferred  Stock  shall  surrender  the Notes at the  offices of the
Company,  which Notes shall be accompanied by irrevocable  written notice to the
Corporation  that the holder elects so to convert such Notes and  specifying the
name or names (with address) in which a certificate or  certificates  evidencing
shares of Preferred Stock are to be issued. The Corporation will make a notation
of the date that a notice of conversion is received,  which date shall be deemed
to be the date of receipt for purposes hereof.

         The Corporation shall deliver to the holder converting the Notes, or to
the nominee or nominees of such person,  certificates  evidencing  the number of
full  shares of  Preferred  Stock to which  such  person  shall be  entitled  as
aforesaid,  together  with a cash  adjustment  of any  fraction  of a  share  as
hereinafter  provided.  Subject to the following  provisions of this  paragraph,
such  conversion  shall  be  deemed  to have  been  made as of the  date of such
surrender  of the Notes and the  person  or  persons  entitled  to  receive  the
Preferred Stock  deliverable  upon conversion of such Notes shall be treated for
all  purposes as the record  holder or holders of such  Preferred  Stock on such
date; provided,  however,  that the Corporation shall not be required to convert
any Notes while the stock transfer books of the  Corporation  are closed for any
purpose,  but the surrender of Notes for conversion during any period while such
books are so closed shall become  effective for conversion  immediately upon the
reopening  of such books as if the  surrender  had been made on the date of such
reopening,  and the conversion shall be at the conversion rate in effect on such
date.

         All notices of conversion shall be irrevocable; provided, however, that
if the  Corporation  has sent  notice of an event  pursuant  to  paragraph  2(e)
hereof,  a holder  of Notes  may,  at its  election,  provide  in its  notice of
conversion  that  the  conversion  of its  Notes  shall be  contingent  upon the
occurrence  of the record date or  effectiveness  of such event (as specified by
such  holder),  provided  that such  notice of  conversion  is  received  by the
Corporation prior to such record date or effective date, as the case may be.

         (c) Protection From Dilution.  (i) If, at any time or from time to time
after the date of this  Note,  the  Company  shall  issue or  distribute  to the
holders of shares of Preferred  Stock  evidence of its  indebtedness,  any other
securities  of the Company or any cash,  property or other  assets  (excluding a
subdivision,  combination  or  reclassification,  or  dividend  or  distribution
payable  solely to  holder of  Preferred  Stock in  shares of  Preferred  Stock,
referred to in Subsection  (c)(ii),  and also  excluding  cash dividends or cash
distributions  paid out of net profits  legally  available  therefor in the full
amount  thereof  (any such  non-excluded  event being  herein  called a "SPECIAL
DIVIDEND"), the Conversion Price shall be adjusted by multiplying the Conversion
Price then in effect by a  fraction,  the  numerator  of which shall be the then
Current  Market Price Per Share of Preferred  Stock in effect on the record date
of such issuance or  distribution  less the fair market value (as  determined in
good faith by the Company's Board of Directors) of the evidence of indebtedness,
cash,  securities  or property,  or other assets issued or  distributed  in such
Special Dividend  applicable to one share of Preferred Stock and the denominator
of which shall be the then Current Market Price Per Share of Preferred  Stock in
effect on the record date of such issuance or  distribution.  An adjustment made
pursuant to this Subsection 2(a) shall become  effective  immediately  after the
record date of any such Special  Dividend.  The then  "CURRENT  MARKET PRICE PER
SHARE OF PREFERRED  STOCK" shall equal the then Current Market Price  multiplied
by the then effective  "conversion rate" (as defined and used in the Certificate
of Designation for the Series D Preferred Stock).

The then Current  Market Price per share (the "CURRENT  MARKET  PRICE") shall be
deemed to be the last sale price of the Common Stock on the trading day prior to
such date or, in case no such reported sales take place on such day, the average
of the last  reported  bid and asked  prices of the Common Stock on such day, in
either case on the principal  national  securities  exchange on which the Common
Stock is admitted to trading or listed,  or if not listed or admitted to trading
on any such exchange,  the representative  closing bid price of the Common Stock
as reported by the National  Association of Securities  Dealers,  Inc. Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined in good faith by the Board of Directors.


                              Page 51 of 99 Pages


<PAGE>

         (ii) In case the Company  shall  hereafter (i) pay a dividend or make a
distribution on its capital stock in shares of Preferred  Stock,  (ii) subdivide
its outstanding shares of Preferred Stock into a greater number of shares, (iii)
combine  its  outstanding  shares of  Preferred  Stock into a smaller  number of
shares or (iv) issue by  reclassification  of its Preferred  Stock any shares of
capital stock of the Company (other than the Conversion Shares),  the Conversion
Price shall be  proportionately  adjusted so that the Notes shall be convertible
into a number and kind of securities  which the holders would have been entitled
to receive after any such event had they converted the Notes  immediately  prior
thereto.  An  adjustment  made  pursuant to this  Subsection  2(b) shall  become
effective  immediately  after  the  record  date in the  case of a  dividend  or
distribution and shall become effective  immediately after the effective date in
the case of a subdivision, combination or reclassification.

         (iii) Except as provided in Subsections (c)(i) and (c)(iv), in case the
Company  shall  hereafter  issue or sell any  Preferred  Stock,  any  securities
convertible into Preferred  Stock,  any rights,  options or warrants to purchase
Preferred Stock or any securities convertible into Preferred Stock, in each case
for a price per share or  entitling  the holders  thereof to purchase  Preferred
Stock at a price per share (determined by dividing (i) the total amount, if any,
received or receivable by the Company in  consideration  of the issuance or sale
of such securities plus the total consideration,  if any, payable to the Company
upon  exercise or  conversion  thereof (the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of  Preferred  Stock  issuable  upon  exercise  or
conversion of such securities) which is less than either the then Current Market
Price Per Share of  Preferred  Stock in effect on the date of such  issuance  or
sale or the Conversion  Price,  the Conversion Price shall be adjusted as of the
date of such issuance or sale by multiplying the Conversion Price then in effect
by a fraction,  the numerator of which shall be (x) the sum of (A) the number of
shares of Preferred  Stock  outstanding  on the record date of such  issuance or
sale plus (B) the Total  Consideration  divided by the Current  Market Price Per
Share of Preferred Stock or the current Conversion Price,  whichever is greater,
and the  denominator  of which  shall be (y) the  number of shares of  Preferred
Stock  outstanding  on the record date of such issuance or sale plus the maximum
number of additional  shares of Preferred  Stock  issued,  sold or issuable upon
exercise or conversion of such securities.

         (iv) In case of any capital reorganization or reclassification,  or any
consolidation  or merger to which the  Company is a party other than a merger or
consolidation in which the Company is the continuing corporation,  or in case of
any sale or  conveyance  to another  entity of the property of the Company as an
entirety  or  substantially  as a  entirety,  or in the  case  of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Note shall have the right  thereafter  to receive on the  conversion  of
this Note the kind and amount of  securities,  cash or other  property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had  this  Note  been  converted  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 2 with respect to the rights and  interests  thereafter of
the Holder of this Note to the end that the provisions set forth in this Section
2  shall  thereafter  correspondingly  be  made  applicable,  as  nearly  as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  Note.  The above  provisions  of this
Subsection   (c)(iv)  shall  similarly  apply  to  successive   reorganizations,
reclassifications,   consolidations,  mergers,  statutory  exchanges,  sales  or
conveyances.  The  Company  shall  require  the issuer of any shares of stock or
other securities or property thereafter deliverable on the exercise of this Note
to be  responsible  for all of the  agreements  and  obligations  of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the Notes not less than
30 days prior to such event. A sale of all or substantially all of the assets of
the Company for a  consideration  consisting  primarily of  securities  shall be
deemed a consolidation or merger for the foregoing purposes.

         (v) In case any event shall occur as to which the other  provisions  of
this Section 2 are not strictly  applicable  but as to which the failure to make
any adjustment  would not fairly protect the  conversion  rights  represented by
this Note in accordance with 


                              Page 52 of 99 Pages


<PAGE>

the essential intent and principles  hereof then, in each such case, the Holders
of Notes may appoint a firm of  independent  public  accountants  of  recognized
national standing reasonably  acceptable to the Company,  which shall give their
opinion as to the adjustment,  if any, on a basis  consistent with the essential
intent and principles  established herein,  necessary to preserve the conversion
rights.  Upon receipt of such  opinion,  the Company will  promptly  mail a copy
thereof  to the  Holder of this Note and shall  make the  adjustments  described
therein.  The fees and expenses of such independent  public accountants shall be
borne by the Company.

         (vi) For  purposes of the  anti-dilution  protection  contained in this
Section (c), at all times  following  the  conversion of all shares of Preferred
Stock into shares of Common Stock,  the term Preferred Stock shall be read to be
Common Stock,  context  permitting,  so that the  anti-dilution  provisions will
continue to protect the  conversion  rights  represented  by this Note after the
conversion of all the Preferred  Stock into the Common Stock in accordance  with
the essential  intent and principles of this Section 3 (it being understood that
prior to such conversion,  the  anti-dilution  provisions of the Preferred Stock
underlying  this Note shall be applicable to any dilutive events with respect to
the Common Stock and protect the Holder from dilution of the Common Stock).

         (d) Reservation of Shares;  Transfer Taxes;  Etc. The Corporation shall
at all times  reserve and keep  available,  out of its  authorized  and unissued
shares of Preferred Stock, solely for the purpose of effecting the conversion of
the Notes,  such  number of shares of its  Preferred  Stock  free of  preemptive
rights as shall be sufficient to effect the conversion of all Notes from time to
time outstanding.  The Corporation shall use its best efforts from time to time,
in accordance with the laws of the State of Delaware, to increase the authorized
number  of  shares  of  Preferred  Stock if at any time the  number of shares of
Preferred Stock not outstanding shall not be sufficient to permit the conversion
of all the then-outstanding Notes.

         The Corporation  shall pay any and all issue or other taxes that may be
payable in  respect of any issue or  delivery  of shares of  Preferred  Stock on
conversion of the Notes. The Corporation shall not, however,  be required to pay
any tax which may be payable in respect of any transfer involved in the issue or
delivery of Preferred Stock (or other securities or assets) in a name other than
that in which the  Notes so  converted  were  registered,  and no such  issue or
delivery  shall be made  unless and until the person  requesting  such issue has
paid to the  Corporation  the  amount  of such  tax or has  established,  to the
satisfaction of the Corporation, that such tax has been paid.

         (e) Prior Notice of Certain Events. In case:

               (i) the  Corporation  shall  declare any  dividend  (or any other
               distribution); or

               (ii) the Corporation  shall authorize the granting to the holders
               of  Preferred  Stock of rights or  warrants to  subscribe  for or
               purchase  any shares of stock of any class or of any other rights
               or warrants; or

               (iii) of any  reclassification  of Preferred  Stock (other than a
               subdivision or combination of the outstanding Preferred Stock, or
               a change in par value, or from par value to no par value, or from
               no par value to par value); or

               (iv) of any consolidation or merger to which the Corporation is a
               party  and  for  which  approval  of  any   stockholders  of  the
               Corporation shall be required,  or of the sale or transfer of all
               or  substantially  all of the assets of the Corporation or of any
               compulsory   share  exchange   whereby  the  Preferred  Stock  is
               converted into other securities, cash or other property; or

               (v) of the voluntary or involuntary  dissolution,  liquidation or
               winding up of the Corporation;

then the Corporation  shall cause to be mailed to the holders of Notes, at their
last addresses as they shall appear upon the books of the Corporation,  at least
20 days prior to the  applicable  record date  hereinafter  specified,  a notice
stating  (x) the date on which a record (if any) is to be taken for the  purpose
of such dividend, distribution or granting of rights or warrants or, if a record
is not to be  taken,  the date as of which the  holders  of  


                              Page 53 of 99 Pages


<PAGE>

Preferred Stock of record to be entitled to such dividend, distribution,  rights
or warrants are to be determined  and a description  of the cash,  securities or
other property to be received by such holders upon such  dividend,  distribution
or   granting   of  rights  or   warrants   or  (y)  the  date  on  which   such
reclassification,   consolidation,   merger,  sale,  transfer,  share  exchange,
dissolution, liquidation or winding up or other liquidation event is expected to
become effective,  the date as of which it is expected that holders of Preferred
Stock of record shall be entitled to exchange  their  shares of Preferred  Stock
for securities or other property  deliverable  upon such exchange,  dissolution,
liquidation  or winding  up or other  liquidation  event and the  consideration,
including securities or other property, to be received by such holders upon such
exchange;  provided,  however, that no failure to mail such notice or any defect
therein or in the mailing  thereof  shall affect the  validity of the  corporate
action required to be specified in such notice.

         (f) Other Changes in Conversion Rate. The Corporation from time to time
may  increase  the  Conversion  Rate by any amount for any period of time if the
period is at least 20 days and if the increase is irrevocable during the period.
Whenever the  Conversion  Rate is so increased,  the  Corporation  shall mail to
holders of record of Notes a notice of the  increase at least 15 days before the
date the increased Conversion Rate takes effect, and such notice shall state the
increased Conversion Rate and the period it will be in effect.

         The  Corporation  may make such  increases in the  Conversion  Rate, in
addition  to  those  required  or  allowed  by this  paragraph  4, as  shall  be
determined by it, as evidenced by a resolution of the Board of Directors,  to be
advisable  in order to avoid or  diminish  any  income  tax to holders of Common
Stock resulting from any dividend or distribution of stock or issuance of rights
or warrants to purchase or subscribe for stock or from any event treated as such
for income tax purposes.


SECTION 3. DEFAULT CONVERSION.

         (a) If this Note and all accrued  interest  shall not have been paid in
full on or  before  the  Maturity  Date or upon  the  occurrence  of an Event of
Default (as defined in Section 7 hereof),  the Holder  shall have the right (the
"Default  Conversion  Right"),  in addition to any other available  remedies set
forth in Section 8 hereof or at law or in equity, to convert up to the lesser of
(i) the  then  outstanding  principal  amount  of this  Note or (ii)  10% of the
original  principal  amount of this  Note,  into the  number of shares of Common
Stock of the Company  ("Common  Stock"),  equal to the amount  converted  by the
Noteholder upon such Event of Default (the "Default  Conversion Amount") divided
by $.001 (the "Default  Conversion Price").  Upon conversion,  the Company shall
pay all accrued and unpaid interest on the Default Conversion Amount.

         (b) To exercise the Default  Conversion Right, the Holder, on or before
the 60th day after the  Maturity  Date,  but before  payment in full of the then
outstanding  principal  and  interest  under  this  Note,  shall  deliver to the
Company,  at its office at as set forth in section 11, or at such other place as
is  designated  in writing by the Company,  a notice (the  "Conversion  Notice")
stating that the Holder is exercising the Default  Conversion Right, the Default
Conversion  Amount  and the  name or  names  in  which  the  Holder  wishes  the
certificates for shares of Common Stock to be issued.

         (c) To the extent  permitted by  applicable  law,  upon exercise of the
Default  Conversion Right, the Holder shall be deemed to be the holder of record
of the shares of Common  Stock  issuable  upon such  exercise  (the  "Conversion
Shares"),  notwithstanding  that the transfer books of the Company shall then be
closed or certificates  representing  such Conversion Shares shall not then have
been actually  delivered to the Holder.  As soon as practicable and in any event
within five (5) days after exercise of the Default Conversion Right, the Company
shall issue and deliver to the Holder a certificate or  certificates  evidencing
the  Conversion  Shares  registered  in the name of the Holder or its  designee,
provided that the Company may require the holder,  by notice given to the Holder
promptly after receipt of the Conversion  Notice, as a condition to the delivery
of such certificate or certificates, to present this Note to the Company for the
placement  hereon of a legend  indicating that the Default  Conversion Right has
been  exercised to the extent of the Default  Conversion  Amount,  and this Note
(unless thereby paid in full) shall be immediately returned to the Holder.


                              Page 54 of 99 Pages


<PAGE>

         (d) The issuance of any shares or other securities upon the exercise of
the  Default  Conversion  Right,  and the  delivery  of  certificates  or  other
instruments representing such shares or other securities,  shall be made without
charge to the  Holder for any tax or other  charge in respect of such  issuance.
The Company shall not, however,  be required to pay any tax which may be payable
in respect of any transfer involved in the issue and delivery of any certificate
in a name other than that of the Holder and the Company shall not be required to
issue or  deliver  any such  certificate  unless and until the person or persons
requesting  the issue  thereof shall have paid to the Company the amount of such
tax or shall have  established to the  satisfaction of the Company that such tax
has been paid.

         (e) The Holder  shall not have,  solely on account of such  status as a
Holder of this Note, any rights of a stockholder  of the Company,  either at law
or in  equity,  or any  notice  of  meetings  of  stockholders  or of any  other
proceedings of the Company except as provided in this Note.

         (f) The Company shall at all times following the Issuance Date, reserve
and keep available out of its  authorized  and unissued  shares of Common Stock,
solely for the purpose of providing  for the exercise of the Default  Conversion
Right,  such number of shares of Common  Stock as shall,  from time to time,  be
sufficient for the exercise of the Default Conversion Right in full. The Company
covenants  that all shares of Common Stock issuable upon exercise of the Default
Conversion Right shall be validly issued, fully paid and nonassessable.

         (g) The  anti-dilution  protections  set forth in Section  2(c)  hereof
shall apply as well to the Default  Conversion  Right and the  adjustment of the
Default Conversion Price hereunder, provided, however, that for purposes of such
application  all  appropriate  references  to  Preferred  Stock shall be read as
references to Common Stock and all references to the  Conversion  Price shall be
read as references to the Default  Conversion  Price,  so as to give the Default
Conversion  Rights,  as  nearly  as  practicable,  the  anti-dilution  and other
protections provided for in section 2(c) with respect to the Optional Conversion
Right.


SECTION 4. FRACTIONAL SHARES.

         (a) The Company  shall not be required to issue  fractions of shares of
Common  Stock or other  capital  stock of the Company  upon the  exercise of the
Optional  and  Default  Conversion  Right.  If any  fraction of a share would be
issuable  on any  exercise  of the  Optional  or  Default  Conversion  Right (or
specified  portions  thereof),  the Company shall  purchase such fraction for an
amount in cash equal to the same  fraction of the  closing  price for the Common
Stock on the  trading  date  immediately  preceding  the date of exercise of the
Optional or Default Conversion Right.


SECTION 5. AFFIRMATIVE COVENANTS OF THE COMPANY.

         The Company covenants and agrees that until the payment in full of this
Note, the Company shall:

         (a) Existence; Business. (i) Preserve, renew and keep in full force and
effect its legal existence and (ii) obtain, preserve,  renew, extend and keep in
full force and effect the licenses, permits, authorizations, patents, trademarks
and trade names material to its business.

         (b) Use of Proceeds. Use the proceeds of the Notes of this issue solely
as set forth in Section 7.7 of the Note and Warrant Purchase  Agreement  between
the  Company  and  various  purchasers  dated  the date  hereof  (the  "Purchase
Agreement")

         (c)  Reports.  Furnish  to the  Holder,  at the time  furnished  to the
Company's   stockholders,   reports   furnished   generally  to  the   Company's
stockholders, and copies of Current Reports on Form 8-K.

         (d) Notice of Events of Default.  Furnish to the Holder prompt  written
notice of any Event of  Default,  specifying  the nature and extent  thereof and
corrective action, if any, proposed to be taken with respect thereto.


                              Page 55 of 99 Pages


<PAGE>

         (e) Authorization of Stock Issuable Upon Conversion.  No later than the
Maturity  Date,  authorize  and  reserve a  sufficient  number of its shares for
exercise of the Default Conversion Right.


SECTION 6. NEGATIVE COVENANTS OF THE COMPANY.

         The Company covenants and agrees with the Holder that until the payment
in full of this Note, the Company shall not:

         (a)  Indebtedness.  Incur,  create,  assume  or  permit  to  exist  any
indebtedness except (i) indebtedness represented by the Notes, (ii) indebtedness
which by its terms is  subordinated  to the Notes in an amount less than $25,000
in the  aggregate  (iii)  indebtedness  in an amount  less than  fifty  thousand
dollars  ($50,000)  incurred  in the  ordinary  course  of  business,  and  (iv)
indebtedness  for borrowed  money  existing on the date hereof and  disclosed in
writing to the Holder on or prior to the date  hereof,  but not any  extensions,
renewals or replacements of such indebtedness;

         (b)  Liens.  Create,  incur,  assume or permit to exist any lien on any
property or assets (including stock or other securities of any person) now owned
or hereafter acquired by the Company,  except (i) liens for taxes not yet due or
which  are  being   contested  by  appropriate   proceedings;   (ii)  carriers',
warehousemen's,  mechanic's,  materialmen's,  repairmen's  or other  like  liens
arising in the ordinary course of business and securing obligations that are not
due or which are being  contested;  or (iii) liens of attachments,  judgments or
awards against the Company (X) which could not reasonably be expected to have an
adverse material effect on the Company or (Y) with respect to which an appeal or
proceeding  for review shall be pending or a stay of  execution  shall have been
obtained,  or  which  are  otherwise  being  contested  in  good  faith  and  by
appropriate  proceedings,  or (iv) purchase  money liens,  equipment  leases and
financings incurred in the ordinary course of business.

         (c) Sale  and  Lease-Back  Transactions.  Enter  into any  arrangement,
directly or  indirectly,  with any person  whereby it shall sell or transfer any
property, real or personal, used or useful in its business, whether now owned or
hereafter acquired, and thereafter rent (including intellectual property), lease
or  license  such  property  or  other  property  which  it  intends  to use for
substantially  the same  purpose  or  purposes  as the  property  being  sold or
transferred.

         (d) Mergers,  Consolidations,  Sales of Assets and Acquisitions.  Merge
into or consolidate  with any other person,  or permit any other person to merge
into or consolidate with it, or sell,  transfer,  lease or otherwise  dispose of
(in one transaction or in a series of transactions) all or a substantial part of
its assets  (whether  now owned or hereafter  acquired)  or  purchase,  lease or
otherwise  acquire (in one  transaction  or a series of  transactions)  all or a
substantial part of the assets of any other person.

         (e)  Dividends  and   Distributions.   Declare  or  pay,   directly  or
indirectly, any dividend or make any other distribution (by reduction of capital
or otherwise),  whether in cash, property,  securities or a combination thereof,
with  respect to any  shares of its  capital  stock or  directly  or  indirectly
redeem, purchase,  retire or otherwise acquire for value any shares of any class
of its  capital  stock or set aside any amount for any such  purpose,  except as
permitted by Section 7.15 of the Note and Warrant Agreement.

         (f)  No   Impairment.   By   amendment   of  its   charter  or  through
reorganization,  consolidation, merger, dissolution, sale of assets or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the  terms of this  Note,  but will at all  times in good  faith  assist  in the
carrying  out of all such terms and in the  taking of all such  action as may be
necessary  or  appropriate  in order to protect the rights of the Holder of this
Note against impairment.


SECTION 7. EVENTS OF DEFAULT DEFINED.

         The following shall each constitute an "Event of Default" hereunder:


                              Page 56 of 99 Pages


<PAGE>

         (a) the failure of the Company to make any payment of  principal  of or
interest on this Note when due and payable;

         (b) the failure of the  Company to observe or perform  any  covenant in
this Note or in the Purchase  Agreement,  and such failure shall have  continued
unremedied for a period of five (5) days;

         (c) if the Company shall:

               (1) admit in writing its inability to pay its debts  generally as
               they become due,

               (2) file a petition in bankruptcy or a petition to take advantage
               of any insolvency act,

               (3) make an assignment for the benefit of its creditors,

               (4) consent to the  appointment of a receiver of itself or of the
               whole or any substantial part of its property,

               (5) on a petition in bankruptcy  filed against,  be adjudicated a
               bankrupt, or

               (6)  file  a  petition  or  answer  seeking   reorganization   or
               arrangement  under  the  federal  bankruptcy  laws  or any  other
               applicable  law or statute of the United States of America or any
               state thereof;

         (d) if a court of competent jurisdiction shall enter an order, judgment
or decree  appointing,  without  the consent of the  Company,  a receiver of the
Company or of the whole or any substantial part of its property,  or approving a
petition filed against it seeking  reorganization  or arrangement of the Company
under the federal  bankruptcy laws or any other applicable law or statute of the
United  States of America or any State  thereof,  and such  order,  judgment  or
decree shall not be vacated or set aside or stayed  within thirty (30) days from
the date of entry thereof;

         (e) if, under the  provisions of any other law for the relief or aid of
debtors, any court of competent  jurisdiction shall assume custody or control of
the  Company  or the  whole or any  substantial  part of its  property  and such
custody or control  shall not be  terminated  or stayed  within thirty (30) days
from the date of assumption of such custody or control;

         (f) the liquidation, dissolution or winding up of the Company;

         (g) the  failure of the  shareholders  to  authorize  and  approve  the
issuance  of these  Notes or the  issuance  of the shares of Series D  Preferred
Stock  underlying  these Notes, the Bridge Warrants or the New Warrants (as such
terms are defined in the Purchase Agreement), or any Common Stock underlying the
foregoing to the extent such authorization is necessary pursuant to the rules of
the Nasdaq National Market or any other applicable law, rule or regulation.

         (h) A default or event of default which remains  uncured  following any
applicable cure period under the Security Agreement;

         (i) A final judgment or judgments for the payment of money in excess of
$1,000,000  in  the  aggregate   shall  be  rendered  by  one  or  more  courts,
administrative or arbitral tribunals or other bodies having jurisdiction against
the Company and the same shall not be discharged (or provision shall not be made
for such  discharge),  or a stay of  execution  thereof  shall not be  procured,
within 30 days from the date of entry thereof and the Company shall not,  within
such 30-day  period,  or such longer period  during which  execution of the same
shall have been stayed,  appeal therefrom and cause the execution  thereof to be
stayed during such appeal; or

SECTION 8. REMEDIES UPON EVENT OF DEFAULT.


                              Page 57 of 99 Pages


<PAGE>

         (a)  Upon  the  occurrence  of an  Event  of  Default,  (i) the  entire
principal  amount of, and all  accrued and unpaid  interest  on, this Note shall
automatically  become immediately due and payable without  presentment,  demand,
protest or other  formalities  of any kind,  all of which are  hereby  expressly
waived by the Company and (ii)  additional  interest shall begin to accrue,  and
shall be considered  immediately due and payable, on the unpaid principal amount
of this Note at the rate of eighteen  percent (18%) per annum and shall continue
to accrue  until the  initial  interest  and  additional  interest  is paid.  In
addition,  the  Holder may take any action  available  to it under the  Purchase
Agreement or at law or in equity or by statute or otherwise.

         (b) No remedy herein conferred upon the Holder of this Note is intended
to be  exclusive  of any other  remedy and each and every such  remedy  shall be
cumulative and shall be in addition to every other remedy given hereunder or now
or hereafter existing at law or in equity or by statute or otherwise.


SECTION 9. NOTE REGISTER.

         (a) The Company shall keep at its principal executive office a register
(herein sometimes referred to as the "Note Register"), in which, subject to such
reasonable  regulations  as it may  prescribe,  but at its  expense  (other than
transfer  taxes,  if any),  the Company shall provide for the  registration  and
transfer of this Note.

         (b) Whenever this Note shall be surrendered at the principal  executive
office  of the  Company  for  transfer  or  exchange,  accompanied  by a written
instrument  of  transfer in form  reasonably  satisfactory  to the Company  duly
executed by the Holder  hereof or his attorney duly  authorized in writing,  the
Company shall execute and deliver in exchange  therefor a new Note or Notes,  as
may be requested by such Holder,  in the same aggregate  unpaid principal amount
and  payable  on the same date as the  principal  amount of the Note or Notes so
surrendered;  each such new Note shall be dated as of the date to which interest
has been paid on the unpaid principal amount of the Note or Notes so surrendered
and shall be in such  principal  amount and  registered in such name or names as
such Holder may designate in writing.

         (c) Upon receipt by the Company of evidence reasonably  satisfactory to
it of the loss,  theft,  destruction or mutilation of this Note and of indemnity
reasonably  satisfactory  to it, and upon  reimbursement  to the  Company of all
reasonable expenses  incidental thereto,  and upon surrender and cancellation of
this Note (in case of  mutilation)  the Company will make and deliver in lieu of
this Note a new Note of like tenor and unpaid  principal  amount and dated as of
the date to which interest has been paid on the unpaid  principal amount of this
Note in lieu of which such new Note is made and delivered.


SECTION 10. REGISTRATION UNDER SECURITIES ACT OF 1933.

         The Holder of this Note shall have  registration  rights as provided in
Section 8 of the Purchase Agreement,  with respect to the shares of Common Stock
underlying the Series D Preferred  Stock  issuable upon  conversion of the Notes
pursuant to the Optional and Default  Conversion  Right.  If the Holder is not a
party to the Purchase  Agreement,  by acceptance of this Note, the Holder agrees
to comply with  provisions  of Section 8 of the  Purchase  Agreement to the same
extent as if it were a party thereto.


SECTION 11. MISCELLANEOUS.

         (a)  Amendments  and Waivers.  The holders of sixty-six and  two-thirds
percent (66 2/3%) or more in principal amount of outstanding Notes of this issue
may waive or otherwise consent to the amendment of any of the provisions hereof,
provided that no such waiver or amendment may reduce the principal  amount of or
interest on any of the Notes of this issue or change the stated  maturity of the
principal or reduce the  percentage of holders of Notes of this issue  necessary
to waive or amend the  provisions  of this  Note,  without  the  consent of each
holder of any Note affected thereby.


                              Page 58 of 99 Pages


<PAGE>

         (b)  Restrictions on  Transferability.  In addition to the restrictions
set forth in Section 9(a) of this Note, the securities  represented by this Note
have  been  acquired  for  investment  and have not been  registered  under  the
Securities Act of 1933, as amended, or the securities laws of any state or other
jurisdiction.  Without  such  registration,  such  securities  may not be  sold,
pledged,  hypothecated or otherwise  transferred,  except pursuant to exemptions
from the Securities  Act of 1933, and the securities  laws of any state or other
jurisdiction.  Notwithstanding  the  above,  the  holder  of this  Note has been
provided  the  registration  rights  contained  in  Section  8 of  the  Purchase
Agreement with respect to the shares of the Company's  Common Stock which may be
acquired upon exercise of the Optional and Default Conversion Right.

         (c)  Forbearance  from  Suit.  No holder of Notes of this  issue  shall
institute any suit or proceeding for the enforcement of the payment of principal
or interest unless the holders of at least fifty-one  percent (51%) in principal
amount  of all of the  outstanding  Notes  of this  issue  join in such  suit or
proceeding.

         (d)  Governing  Law.  This Note shall be governed by and  construed  in
accordance  with the laws of the  State of New York,  excluding  the body of law
relating to conflict of laws. Notwithstanding anything to the contrary contained
herein, in no event may the effective rate of interest  collected or received by
the Holder exceed that which may be charged, collected or received by the Holder
under applicable law.

         (e) Interpretation. If any term or provision of this Note shall be held
invalid,  illegal  or  unenforceable,  the  validity  of  all  other  terms  and
provisions hereof shall in no way be affected thereby.

         (f) Successors and Assigns. This Note shall be binding upon the Company
and its  successors and assigns and shall inure to the benefit of the Holder and
its successors and assigns.

         (g) Notices. All notices, requests,  consents and demands shall be made
in writing and shall be mailed  postage  prepaid,  or delivered by hand,  to the
Company or to the Holder thereof at their  respective  addresses set forth below
or to such other  address  as may be  furnished  in  writing to the other  party
hereto:

                  If to the Holder:         At the address shown on Schedule A 
                                            attached hereto.

                  with a copy to:           Paramount Capital, Inc.
                                            787 Seventh Avenue
                                            New York, NY  10019
                                            Attn: David R. Walner

                  If to the Company:        Genta Incorporated
                                            3350 General Atomics Court
                                            San Diego, CA 92121
                                            Attention: Chief Executive Officer

         (h) Saturdays,  Sundays,  Holidays. If any date that may at any time be
specified  in this Note as a date for the making of any payment of  principal or
interest under this Note shall fall on Saturday, Sunday or on a day which in New
York  shall be a legal  holiday,  then the date for the  making of that  payment
shall be the  next  subsequent  day  which is not a  Saturday,  Sunday  or legal
holiday.

         (i) Purchase Agreement.  This Note is subject to the terms contained in
the  Purchase  Agreement  dated the date hereof  between the Company and certain
purchasers of the Senior Secured Convertible Bridge Notes and the holder of this
Note is entitled to the benefits of such Purchase Agreement and may, in addition
to any rights hereunder, enforce the agreements of the Company contained therein
and exercise the remedies provided for thereby or otherwise available in respect
thereof.


                              Page 59 of 99 Pages


<PAGE>

         IN WITNESS  WHEREOF,  this Note has been  executed  and  delivered as a
sealed  instrument  on the date  first  above  written  by the  duly  authorized
representative of the Company.


ATTEST:                             GENTA INCORPORATED


                                    By: /s/Thomas H. Adams
- --------------------                    -------------------------
                                    Name: Dr. Thomas H. Adams
                                    Its: President and Chief Executive Officer



(Corporate Seal)


                              Page 60 of 99 Pages


<PAGE>


                                    EXHIBIT H

THESE  SECURITIES HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933 OR
ANY APPLICABLE STATE  SECURITIES  LAWS. THEY MAY NOT BE SOLD,  OFFERED FOR SALE,
PLEDGED  OR  HYPOTHECATED   OR  OTHERWISE   TRANSFERRED  IN  THE  ABSENCE  OF  A
REGISTRATION  STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES  UNDER SUCH ACT
OR AN EXEMPTION  THEREFROM.  ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE
STATE SECURITIES LAWS.



                               GENTA INCORPORATED


              Class A Bridge Warrant for the Purchase of Shares of
                                  Common Stock


No. CA-1                                                        2,730,000 Shares


         FOR VALUE RECEIVED,  GENTA  INCORPORATED.,  a Delaware corporation (the
"COMPANY"),  hereby certifies that THE ARIES DOMESTIC FUND, LP or its registered
assigns (the "Holder") is entitled to purchase from the Company,  subject to the
provisions of this Warrant (the "Warrant"), at any time commencing upon the date
hereof (the  "INITIAL  EXERCISE  DATE"),  and prior to 5:00 P.M.,  New York City
time, on the date which is five (5) years from the date hereof (the "TERMINATION
DATE"),  2,730,000  fully paid and  non-assessable  shares of the Common  Stock,
$.001 par value, of the Company ("Common Stock"), at an exercise price of $0.001
per share of Common Stock for an aggregate  exercise price of TWO THOUSAND SEVEN
HUNDRED AND THIRTY DOLLARS ($2,730.00) (the aggregate purchase price payable for
the  Warrant  Shares  hereunder  is  hereinafter  sometimes  referred  to as the
"AGGREGATE EXERCISE PRICE"). The number of shares of Common Stock to be received
upon  exercise of this Warrant and the price to be paid for each share of Common
Stock are subject to possible  adjustment  from time to time as hereinafter  set
forth.  The shares of Common Stock or other  securities or property  deliverable
upon  such  exercise  as  adjusted  from time to time is  hereinafter  sometimes
referred to as the "WARRANT  SHARES."  The  exercise  price of a share of Common
Stock in effect  at any time and as  adjusted  from time to time is  hereinafter
sometimes  referred to as the "PER SHARE EXERCISE PRICE." The Per Share Exercise
Price is subject to adjustment as hereinafter provided; in the event of any such
adjustment,  the number of Warrant  Shares  shall be adjusted  by  dividing  the
Aggregate  Exercise Price by the Per Share Exercise Price in effect  immediately
after  such  adjustment.   The  Aggregate  Exercise  Price  is  not  subject  to
adjustment.

         1. EXERCISE OF WARRANT.

         (a) This Warrant may be  exercised in whole or in part,  at any time by
the Holder  commencing on the Initial Exercise Date and prior to the Termination
Date, by  presentation  and  surrender of this  Warrant,  together with the duly
executed  subscription form attached at the end hereof, at the address set forth
in subsection 8(a) hereof,  together with payment, by certified or official bank
check or wire  transfer  payable to the order of the Company,  of the  Aggregate
Exercise Price or the proportionate part thereof if exercised in part.

         (b) If this Warrant is exercised in part only, the Company shall,  upon
presentation of this Warrant upon such exercise, execute and deliver (along with
the certificate for the Warrant Shares  purchased) a new Warrant  evidencing the
rights of the  Holder  hereof to  purchase  the  balance of the  Warrant  Shares
purchasable  hereunder  upon the same terms and  conditions as herein set forth.
Upon  proper  exercise  of this  Warrant,  the Company  promptly  shall  deliver
certificates for the Warrant Shares to the Holder duly legended as authorized by
the subscription  form. No fractional  shares or scrip  representing  fractional
shares shall be issued upon exercise of this Warrant;  provided that the Company
shall pay to the holders of the Warrant cash in lieu of such fractional shares.


                               Page 61 of 99 Pages


<PAGE>

         2. RESERVATION OF WARRANT SHARES; FULLY PAID SHARES; TAXES. The Company
hereby  represents that it has, and until expiration of this Warrant agrees that
it shall,  reserve for issuance or delivery upon exercise of this Warrant,  such
number of shares of the Common Stock as shall be required  for  issuance  and/or
delivery  upon  exercise  of this  Warrant in full,  and agrees that all Warrant
Shares so  issued  and/or  delivered  will be  validly  issued,  fully  paid and
non-assessable,  and  further  agrees to pay all taxes and  charges  that may be
imposed upon such issuance and/or delivery.

         3. PROTECTION AGAINST DILUTION.

         (a) In the event the  Company  shall,  at any time or from time to time
after the date of issuance of this  Warrant,  issue or  distribute to all of the
holders of its shares of Common Stock  evidence of its  indebtedness,  any other
securities of the Company or any cash,  property or other assets (any such event
being herein called a "SPECIAL DIVIDEND"), the Per Share Exercise Price shall be
adjusted  by  multiplying  the Per  Share  Exercise  Price  then in  effect by a
fraction,  the  numerator  of which shall be the then  Current  Market Price (as
defined in paragraph  3(k) below) of the Common Stock,  less the Current  Market
Price of the Special  Dividend  issued or distributed in respect of one share of
Common Stock,  and the denominator of which shall be the Current Market Price of
the Common Stock.  Such adjustment  shall be made  successively  whenever such a
record  date  is  fixed.  Such  adjustment  shall  be  made  whenever  any  such
distribution  is made and shall become  effective  immediately  after the record
date  for  the   determination   of   shareholders   entitled  to  receive  such
distribution.

         (b) In case the Company  shall  hereafter  (i) pay a dividend or make a
distribution on its capital stock in shares of Common Stock,  (ii) subdivide its
outstanding  shares  of Common  Stock  into a greater  number of  shares,  (iii)
combine its  outstanding  shares of Common Stock into a smaller number of shares
or (iv)  issue by  reclassification  of its  Common  Stock any shares of capital
stock of the Company, the Per Share Exercise Price shall be adjusted to be equal
to a fraction,  the numerator of which shall be the Aggregate Exercise Price and
the  denominator of which shall be the number of shares of Common Stock or other
capital stock of the Company  issuable  upon  exercise of this Warrant  assuming
this Warrant had been exercised  immediately prior to such action. An adjustment
made pursuant to this subsection 3(b) shall become effective  immediately  after
the  record  date in the case of a dividend  or  distribution  and shall  become
effective  immediately  after the effective  date in the case of a  subdivision,
combination or reclassification.

         (c)(i) Except as provided in subsections 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share  (determined by dividing (i) the total amount,  if any, received
or  receivable by the Company in  consideration  of the issuance or sale of such
securities plus the consideration,  if any, payable to the Company upon exercise
or conversion  thereof  (collectively,  the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of Common  Stock  issued,  sold or  issuable  upon
exercise or conversion of such  securities)  which is less than the then Current
Market  Price of the Common  Stock (as defined  below) but not below the current
Per Share Exercise Price (which event is governed by subsection  3(c)(ii)),  the
Per Share  Exercise  Price shall be adjusted as of the date of such  issuance or
sale by  multiplying  the Per Share Exercise Price then in effect by a fraction,
the  numerator  of which  shall be (x) the sum of (A) the  number  of  shares of
Common Stock  outstanding  on the record date of such  issuance or sale plus (B)
the Total Consideration divided by the Current Market Price of the Common Stock,
and the  denominator  of which shall be (y) the number of shares of Common Stock
outstanding  on the record date of such issuance or sale plus the maximum number
of additional  shares of Common Stock issued,  sold or issuable upon exercise or
conversion of such securities.

         (c)(ii) Except as provided in subsection 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share (the  "ISSUE  PRICE"),  (determined  by  dividing  (i) the Total
Consideration  by (ii) the number of additional  


                               Page 62 of 99 Pages


<PAGE>

shares of Common Stock issuable upon exercise or conversion of such  securities)
which is less than the then  current Per Share  Exercise  Price in effect on the
record date of such issuance,  the Per Share Exercise Price shall be adjusted to
equal the Issue Price.

         (d) In the event of any capital reorganization or reclassification,  or
any  consolidation or merger to which the Company is a party other than a merger
or consolidation in which the Company is the continuing corporation,  or in case
of any sale or conveyance to another entity of the property of the Company as an
entirety  or  substantially  as an  entirety,  or in the  case of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Warrant  shall have the right  thereafter  to receive on the exercise of
this Warrant the kind and amount of securities, cash or other property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had this Warrant been  exercised  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 3 with respect to the rights and  interests  thereafter of
the  Holder of this  Warrant  to the end that the  provisions  set forth in this
Section 3 shall thereafter  correspondingly be made applicable, as nearly as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  exercise of this  Warrant.  The above
provisions  of  this   subsection  3(e)  shall  similarly  apply  to  successive
reorganizations,    reclassifications,    consolidations,   mergers,   statutory
exchanges,  sales or  conveyances.  The  issuer of any  shares of stock or other
securities or property  thereafter  deliverable  on the exercise of this Warrant
shall be responsible  for all of the  agreements and  obligations of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the  Warrants  not less
than 30 days  prior to such  event.  A sale of all or  substantially  all of the
assets of the Company for a  consideration  consisting  primarily of  securities
shall be deemed a consolidation or merger for the foregoing purposes.

         (e) In case any event shall occur as to which the other  provisions  of
this Section 3 are not strictly  applicable  but as to which the failure to make
any adjustment would not fairly protect the purchase rights  represented by this
Warrant in accordance with the essential  intent and principles  hereof then, in
each such case,  the  Holders of Warrants  representing  the right to purchase a
majority of the Warrant Shares subject to all outstanding Warrants may appoint a
firm  of  independent  public   accountants  of  recognized   national  standing
reasonably  acceptable to the Company,  which shall give their opinion as to the
adjustment,  if  any,  on a basis  consistent  with  the  essential  intent  and
principles  established  herein,  necessary  to  preserve  the  purchase  rights
represented  by the  Warrants.  Upon receipt of such  opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants shall be borne by the Company.

         (f) Whenever the Per Share Exercise Price payable upon exercise of each
Warrant is adjusted  pursuant to this  Section 3, the number of shares of Common
Stock underlying a Warrant shall  simultaneously be adjusted to equal the number
obtained by dividing  the  Aggregate  Exercise  Price by the  adjusted Per Share
Exercise Price.

         (g) No  adjustment  in the Per Share  Exercise  Price shall be required
unless such  adjustment  would require an increase or decrease of at least $0.01
per share of Common Stock;  provided,  however,  that any  adjustments  which by
reason of this  subsection  3(g) are not  required  to be made  shall be carried
forward and taken into account in any subsequent  adjustment.  All  calculations
under this Section 3 shall be made to the nearest cent or to the nearest 1/100th
of a share,  as the case may be.  Anything  in this  Section  3 to the  contrary
notwithstanding,  the Company  shall be entitled to make such  reductions in the
Per Share Exercise Price, in addition to those required by this Section 3, as it
in its discretion  shall deem to be advisable in order that any stock  dividend,
subdivision of shares or  distribution of rights to purchase stock or securities
convertible  or  exchangeable  for stock  hereafter  made by the  Company to its
stockholders shall not be taxable.


                               Page 63 of 99 Pages


<PAGE>

         (h)  Whenever the Per Share  Exercise  Price is adjusted as provided in
this Section 3 and upon any  modification  of the rights of a Holder of Warrants
in accordance  with this Section 3, the Company shall  promptly  obtain,  at its
expense, a certificate of a firm of independent public accountants of recognized
standing  selected by the Board of Directors (who may be the regular auditors of
the  Company)  setting  forth the Per  Share  Exercise  Price and the  number of
Warrant Shares after such adjustment or the effect of such modification, a brief
statement of the facts requiring such adjustment or modification  and the manner
of computing the same and cause copies of such  certificate  to be mailed to the
Holders of the Warrants.

         (i) If the Board of Directors of the Company shall declare any dividend
or other  distribution  with respect to the Common Stock, the Company shall mail
notice thereof to the Holders of the Warrants not less than 30 days prior to the
record date fixed for determining  stockholders  entitled to participate in such
dividend or other distribution.

         (j) If, as a result of an  adjustment  made pursuant to this Section 3,
the Holder of any Warrant  thereafter  surrendered  for  exercise  shall  become
entitled to receive  shares of two or more classes of capital stock or shares of
Common  Stock and other  capital  stock of the  Company,  the Board of Directors
(whose  determination  shall be  conclusive  and shall be described in a written
notice to the  Holder of any  Warrant  promptly  after  such  adjustment)  shall
determine  the  allocation of the adjusted Per Share  Exercise  Price between or
among  shares or such  classes  of capital  stock or shares of Common  Stock and
other capital stock.

         (k) For the purpose of any computation  under Section 3 above, the then
Current  Market Price per share (the "CURRENT  MARKET PRICE") shall be deemed to
be the last sale price of the Common Stock on the trading day prior to such date
or, in case no such  reported  sales take place on such day,  the average of the
last  reported  bid and asked  prices of the Common Stock on such day, in either
case on the principal national  securities exchange on which the Common Stock is
admitted  to trading or listed,  or if not listed or  admitted to trading on any
such  exchange,  the  representative  closing  bid price of the Common  Stock as
reported by the National  Association  of  Securities  Dealers,  Inc.  Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined by agreement between the Company's Board of Directors,  on the one
part, and the Holders of Warrants  representing the right to purchase a majority
of the Warrant Shares subject to all outstanding  Warrants,  on the second part.
If the Board of Directors  and such Holders fail to agree on the Current  Market
Price  within 60 days of the date of the action  giving  rise to any  adjustment
pursuant to this Section 3, such Holders  shall be entitled to appoint a firm of
independent  public  accountants or appraisers of recognized  national  standing
reasonably acceptable to the Company,  which shall give their opinion as to such
Current  Market  Price on a basis  consistent  with  the  essential  intent  and
principles  established herein.  Upon receipt of such opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants or appraisers shall be borne by the Company.

         4. REGISTRATION UNDER SECURITIES ACT OF 1933. The resale of the Warrant
Shares shall be  registered on the Shelf  Registration  Statement (as defined in
Article 8 of the Note and Warrant Purchase Agreement (the "Purchase  Agreement")
dated as of January 28, 1997, by and among the Company, The Aries Fund, a Cayman
Island Trust, and The Aries Domestic Fund, L.P., a Delaware limited partnership)
and  certain   purchasers  and  the  Holder  of  this  Warrant  shall  have  the
registration rights as provided in Article 8 of the Purchase  Agreement.  If the
Holder is not a party to the Purchase  Agreement,  by acceptance of this Warrant
the  Holder  agrees to  comply  with  provisions  of  Article 8 of the  Purchase
Agreement to the same extent as if it were a party thereto.

         5. LIMITED TRANSFERABILITY.  This Warrant may not be sold, transferred,
assigned or  hypothecated by the Holder except in compliance with the provisions
of the Act and the  applicable  state  securities  "blue  sky"  laws,  and is so
transferable  only  upon the  books of the  Company  which it shall  cause to be
maintained for such purpose. The Company may treat the registered Holder of this
Warrant as he or it appears on the Company's books 


                               Page 64 of 99 Pages
<PAGE>

at any time as the Holder for all purposes.  The Company shall permit any Holder
of a Warrant  or his duly  authorized  attorney,  upon  written  request  during
ordinary  business  hours,  to inspect and copy or make  extracts from its books
showing  the  registered  holders of  Warrants.  All  Warrants  issued  upon the
transfer  or  assignment  of this  Warrant  will be dated  the same date as this
Warrant, and all rights of the holder thereof shall be identical to those of the
Holder.

         6. LOSS, ETC., OF WARRANT. Upon receipt of evidence satisfactory to the
Company of the loss,  theft,  destruction or mutilation of this Warrant,  and of
indemnity reasonably  satisfactory to the Company, if lost, stolen or destroyed,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall  execute and  deliver to the Holder a new Warrant of like date,  tenor and
denomination.

         7. STATUS OF HOLDER.  This  Warrant does not confer upon the Holder any
right  to vote or to  consent  to or  receive  notice  as a  stockholder  of the
Company, as such, in respect of any matters  whatsoever,  or any other rights or
liabilities as a stockholder, prior to the exercise hereof.

         8. NOTICES.  No notice or other  communication under this Warrant shall
be effective unless,  but any notice or other  communication  shall be effective
and shall be deemed to have been given if, the same is in writing  and is mailed
by first-class mail, postage prepaid, addressed to:

          (a) the  Company  at  3550  General  Atomic  Corporation,  San  Diego,
          California 92121, Attention: Thomas H. Adams, or such other address as
          the Company has designated in writing to the Holder; or

          (b) the Holder at the address  indicated in the notice  provisions  to
          the  Purchase  Agreement,  or other  such  address  as the  Holder has
          designated in writing to the Company.

         9. OPTIONAL  CONVERSION.  Each warrant shall be convertible  into a New
Warrant (as  hereinafter  defined) on a one for one basis.  "New Warrants" shall
mean a new class of warrants  entitling the holders thereof to purchase,  at any
time on or before  the date which is five (5) years  from the date  hereof,  one
share of Common Stock at an exercise price equal to the lesser of (a) $0.15, and
(b) fifty percent (50%) of the average closing bid price of the Common Stock for
either (i) the thirty (30) consecutive  trading days immediately  succeeding the
date of the Required Shareholder Approval, if any (the "Approval Date"), or (ii)
the five (5) consecutive  trading days preceding the Approval Date if any. Other
than the exercise price, the New Warrants shall have the same terms as the Class
A  Warrants.  To the  extent  that  there is no  Required  Shareholder  Approval
necessary the foregoing clause (b) shall ignored.

         Notwithstanding  the foregoing,  the New Warrants' exercise price shall
be  adjusted at the time of the Final  Closing  Date (as that term is defined in
the Letter between Genta and Paramount  Capital Inc., dated January 28, 1997) if
the exercise price of the Offering  Warrants (as defined below) is less than the
exercise  price of the New  Warrants.  In such event the New  Warrants  exercise
price shall be reduced to equal 50% of the then  current  exercise  price of the
Offering  Warrants (as hereafter  defined).  "Offering  Warrants" shall mean the
warrants  described  in  paragraph  7 of the  Letter  between  the  Company  and
Paramount Capital, Inc. dated January 28, 1997.

         "Required  Shareholder  Approval"  shall  mean  the  authorization  and
approval  by the holders of the Common  Stock of the Company of the  issuance of
the shares of Common Stock underlying the Company's  Senior Secured  Convertible
Bridge Notes, to the extent such authorization is required pursuant to the rules
of the Nasdaq National Market or any other statute, rule or regulation.

         10.  HEADINGS.  The headings of this  Warrant  have been  inserted as a
matter of convenience and shall not affect the construction hereof.

         11.  APPLICABLE LAW. This Warrant shall be governed by and construed in
accordance  with the law of the  State  of New York  without  giving  effect  to
principles of conflicts of law thereof.


                                 Page 65 of 99 Pages


<PAGE>

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its Chief  Executive  Officer and its corporate seal to be hereunto  affixed and
attested by its Secretary this January 28, 1997


                                        GENTA INCORPORATED



                                        By: /s/Thomas H. Adams
                                            ----------------------
                                               Name: Thomas H. Adams
                                               Title:    Chairman


ATTEST:


/s/
- --------------------
     Secretary



[Corporate Seal]


                                 Page 66 of 99 Pages


<PAGE>

                                  SUBSCRIPTION

         The   undersigned,   ____________________________,   pursuant   to  the
provisions  of the  foregoing  Warrant,  hereby  elects to  exercise  the within
Warrant to the extent of purchasing _____________________ shares of Common Stock
thereunder and hereby makes payment of $_______________ by certified or official
bank check in payment of the exercise price therefor.

Dated:_______________                    Signature:_____________________________

                                         Address:_______________________________


                                   ASSIGNMENT

         FOR  VALUE  RECEIVED   _______________________________________   hereby
sells,  assigns and  transfers  unto  _____________________________________  the
foregoing  Warrant  and all  rights  evidenced  thereby,  and  does  irrevocably
constitute and appoint _____________________________, attorney, to transfer said
Warrant on the books of Genta, Inc.


Dated:_______________                    Signature:_____________________________

                                         Address:______________________________


                               PARTIAL ASSIGNMENT

         FOR  VALUE  RECEIVED   __________________________  hereby  assigns  and
transfers unto _________________________ the right to purchase __________ shares
of the Common  Stock,  no par value per  share,  of Genta,  Inc.  covered by the
foregoing  Warrant,  and a  proportionate  part of said  Warrant  and the rights
evidenced    thereby,    and   does    irrevocably    constitute   and   appoint
__________________________,  attorney,  to transfer that part of said Warrant on
the books of Genta, Inc.


Dated:_______________                    Signature:___________________________

                                         Address:_____________________________


                                 Page 67 of 99 Pages


<PAGE>


                                    EXHIBIT I

THESE  SECURITIES HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933 OR
ANY APPLICABLE STATE  SECURITIES  LAWS. THEY MAY NOT BE SOLD,  OFFERED FOR SALE,
PLEDGED  OR  HYPOTHECATED   OR  OTHERWISE   TRANSFERRED  IN  THE  ABSENCE  OF  A
REGISTRATION  STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES  UNDER SUCH ACT
OR AN EXEMPTION  THEREFROM.  ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE
STATE SECURITIES LAWS.



                               GENTA INCORPORATED


              Class A Bridge Warrant for the Purchase of Shares of
                                  Common Stock


No. CA-2                                                        5,070,000 Shares


         FOR VALUE RECEIVED,  GENTA  INCORPORATED.,  a Delaware corporation (the
"COMPANY"), hereby certifies that THE ARIES TRUST or its registered assigns (the
"Holder") is entitled to purchase from the Company, subject to the provisions of
this Warrant (the  "Warrant"),  at any time commencing upon the date hereof (the
"INITIAL  EXERCISE  DATE"),  and prior to 5:00 P.M.,  New York City time, on the
date  which is five (5) years from the date  hereof  (the  "TERMINATION  DATE"),
5,070,000 fully paid and  non-assessable  shares of the Common Stock,  $.001 par
value, of the Company ("Common Stock"), at an exercise price of $0.001 per share
of Common Stock for an aggregate exercise price of FIVE THOUSAND SEVENTY DOLLARS
($5,070.00)  (the  aggregate  purchase  price  payable  for the  Warrant  Shares
hereunder  is  hereinafter  sometimes  referred  to as the  "AGGREGATE  EXERCISE
PRICE").  The number of shares of Common Stock to be received  upon  exercise of
this Warrant and the price to be paid for each share of Common Stock are subject
to possible adjustment from time to time as hereinafter set forth. The shares of
Common Stock or other  securities or property  deliverable upon such exercise as
adjusted from time to time is hereinafter  sometimes referred to as the "WARRANT
SHARES." The exercise price of a share of Common Stock in effect at any time and
as adjusted from time to time is hereinafter  sometimes  referred to as the "PER
SHARE EXERCISE  PRICE." The Per Share Exercise Price is subject to adjustment as
hereinafter provided; in the event of any such adjustment, the number of Warrant
Shares shall be adjusted by dividing  the  Aggregate  Exercise  Price by the Per
Share Exercise Price in effect immediately after such adjustment.  The Aggregate
Exercise Price is not subject to adjustment.

          1. EXERCISE OF WARRANT.

         (a) This Warrant may be  exercised in whole or in part,  at any time by
the Holder  commencing on the Initial Exercise Date and prior to the Termination
Date, by  presentation  and  surrender of this  Warrant,  together with the duly
executed  subscription form attached at the end hereof, at the address set forth
in subsection 8(a) hereof,  together with payment, by certified or official bank
check or wire  transfer  payable to the order of the Company,  of the  Aggregate
Exercise Price or the proportionate part thereof if exercised in part.

         (b) If this Warrant is exercised in part only, the Company shall,  upon
presentation of this Warrant upon such exercise, execute and deliver (along with
the certificate for the Warrant Shares  purchased) a new Warrant  evidencing the
rights of the  Holder  hereof to  purchase  the  balance of the  Warrant  Shares
purchasable  hereunder  upon the same terms and  conditions as herein set forth.
Upon  proper  exercise  of this  Warrant,  the Company  promptly  shall  deliver
certificates for the Warrant Shares to the Holder duly legended as authorized by
the subscription  form. No fractional  shares or scrip  representing  fractional
shares shall be issued upon exercise of this Warrant;  provided that the Company
shall pay to the holders of the Warrant cash in lieu of such fractional shares.


                               Page 68 of 99 Pages


<PAGE>

         2. RESERVATION OF WARRANT SHARES; FULLY PAID SHARES; TAXES. The Company
hereby  represents that it has, and until expiration of this Warrant agrees that
it shall,  reserve for issuance or delivery upon exercise of this Warrant,  such
number of shares of the Common Stock as shall be required  for  issuance  and/or
delivery  upon  exercise  of this  Warrant in full,  and agrees that all Warrant
Shares so  issued  and/or  delivered  will be  validly  issued,  fully  paid and
non-assessable,  and  further  agrees to pay all taxes and  charges  that may be
imposed upon such issuance and/or delivery.

         3. PROTECTION AGAINST DILUTION.

         (a) In the event the  Company  shall,  at any time or from time to time
after the date of issuance of this  Warrant,  issue or  distribute to all of the
holders of its shares of Common Stock  evidence of its  indebtedness,  any other
securities of the Company or any cash,  property or other assets (any such event
being herein called a "SPECIAL DIVIDEND"), the Per Share Exercise Price shall be
adjusted  by  multiplying  the Per  Share  Exercise  Price  then in  effect by a
fraction,  the  numerator  of which shall be the then  Current  Market Price (as
defined in paragraph  3(k) below) of the Common Stock,  less the Current  Market
Price of the Special  Dividend  issued or distributed in respect of one share of
Common Stock,  and the denominator of which shall be the Current Market Price of
the Common Stock.  Such adjustment  shall be made  successively  whenever such a
record  date  is  fixed.  Such  adjustment  shall  be  made  whenever  any  such
distribution  is made and shall become  effective  immediately  after the record
date  for  the   determination   of   shareholders   entitled  to  receive  such
distribution.

         (b) In case the Company  shall  hereafter  (i) pay a dividend or make a
distribution on its capital stock in shares of Common Stock,  (ii) subdivide its
outstanding  shares  of Common  Stock  into a greater  number of  shares,  (iii)
combine its  outstanding  shares of Common Stock into a smaller number of shares
or (iv)  issue by  reclassification  of its  Common  Stock any shares of capital
stock of the Company, the Per Share Exercise Price shall be adjusted to be equal
to a fraction,  the numerator of which shall be the Aggregate Exercise Price and
the  denominator of which shall be the number of shares of Common Stock or other
capital stock of the Company  issuable  upon  exercise of this Warrant  assuming
this Warrant had been exercised  immediately prior to such action. An adjustment
made pursuant to this subsection 3(b) shall become effective  immediately  after
the  record  date in the case of a dividend  or  distribution  and shall  become
effective  immediately  after the effective  date in the case of a  subdivision,
combination or reclassification.

         (c)(i) Except as provided in subsections 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share  (determined by dividing (i) the total amount,  if any, received
or  receivable by the Company in  consideration  of the issuance or sale of such
securities plus the consideration,  if any, payable to the Company upon exercise
or conversion  thereof  (collectively,  the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of Common  Stock  issued,  sold or  issuable  upon
exercise or conversion of such  securities)  which is less than the then Current
Market  Price of the Common  Stock (as defined  below) but not below the current
Per Share Exercise Price (which event is governed by subsection  3(c)(ii)),  the
Per Share  Exercise  Price shall be adjusted as of the date of such  issuance or
sale by  multiplying  the Per Share Exercise Price then in effect by a fraction,
the  numerator  of which  shall be (x) the sum of (A) the  number  of  shares of
Common Stock  outstanding  on the record date of such  issuance or sale plus (B)
the Total Consideration divided by the Current Market Price of the Common Stock,
and the  denominator  of which shall be (y) the number of shares of Common Stock
outstanding  on the record date of such issuance or sale plus the maximum number
of additional  shares of Common Stock issued,  sold or issuable upon exercise or
conversion of such securities.

         (c)(ii) Except as provided in subsection 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share (the  "ISSUE  PRICE"),  (determined  by  dividing  (i) the Total
Consideration  by (ii) the number of additional  


                               Page 69 of 99 Pages


<PAGE>

shares of Common Stock issuable upon exercise or conversion of such  securities)
which is less than the then  current Per Share  Exercise  Price in effect on the
record date of such issuance,  the Per Share Exercise Price shall be adjusted to
equal the Issue Price.

         (d) In the event of any capital reorganization or reclassification,  or
any  consolidation or merger to which the Company is a party other than a merger
or consolidation in which the Company is the continuing corporation,  or in case
of any sale or conveyance to another entity of the property of the Company as an
entirety  or  substantially  as an  entirety,  or in the  case of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Warrant  shall have the right  thereafter  to receive on the exercise of
this Warrant the kind and amount of securities, cash or other property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had this Warrant been  exercised  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 3 with respect to the rights and  interests  thereafter of
the  Holder of this  Warrant  to the end that the  provisions  set forth in this
Section 3 shall thereafter  correspondingly be made applicable, as nearly as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  exercise of this  Warrant.  The above
provisions  of  this   subsection  3(e)  shall  similarly  apply  to  successive
reorganizations,    reclassifications,    consolidations,   mergers,   statutory
exchanges,  sales or  conveyances.  The  issuer of any  shares of stock or other
securities or property  thereafter  deliverable  on the exercise of this Warrant
shall be responsible  for all of the  agreements and  obligations of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the  Warrants  not less
than 30 days  prior to such  event.  A sale of all or  substantially  all of the
assets of the Company for a  consideration  consisting  primarily of  securities
shall be deemed a consolidation or merger for the foregoing purposes.

         (e) In case any event shall occur as to which the other  provisions  of
this Section 3 are not strictly  applicable  but as to which the failure to make
any adjustment would not fairly protect the purchase rights  represented by this
Warrant in accordance with the essential  intent and principles  hereof then, in
each such case,  the  Holders of Warrants  representing  the right to purchase a
majority of the Warrant Shares subject to all outstanding Warrants may appoint a
firm  of  independent  public   accountants  of  recognized   national  standing
reasonably  acceptable to the Company,  which shall give their opinion as to the
adjustment,  if  any,  on a basis  consistent  with  the  essential  intent  and
principles  established  herein,  necessary  to  preserve  the  purchase  rights
represented  by the  Warrants.  Upon receipt of such  opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants shall be borne by the Company.

         (f) Whenever the Per Share Exercise Price payable upon exercise of each
Warrant is adjusted  pursuant to this  Section 3, the number of shares of Common
Stock underlying a Warrant shall  simultaneously be adjusted to equal the number
obtained by dividing  the  Aggregate  Exercise  Price by the  adjusted Per Share
Exercise Price.

         (g) No  adjustment  in the Per Share  Exercise  Price shall be required
unless such  adjustment  would require an increase or decrease of at least $0.01
per share of Common Stock;  provided,  however,  that any  adjustments  which by
reason of this  subsection  3(g) are not  required  to be made  shall be carried
forward and taken into account in any subsequent  adjustment.  All  calculations
under this Section 3 shall be made to the nearest cent or to the nearest 1/100th
of a share,  as the case may be.  Anything  in this  Section  3 to the  contrary
notwithstanding,  the Company  shall be entitled to make such  reductions in the
Per Share Exercise Price, in addition to those required by this Section 3, as it
in its discretion  shall deem to be advisable in order that any stock  dividend,
subdivision of shares or  distribution of rights to purchase stock or securities
convertible  or  exchangeable  for stock  hereafter  made by the  Company to its
stockholders shall not be taxable.


                               Page 70 of 99 Pages


<PAGE>

         (h)  Whenever the Per Share  Exercise  Price is adjusted as provided in
this Section 3 and upon any  modification  of the rights of a Holder of Warrants
in accordance  with this Section 3, the Company shall  promptly  obtain,  at its
expense, a certificate of a firm of independent public accountants of recognized
standing  selected by the Board of Directors (who may be the regular auditors of
the  Company)  setting  forth the Per  Share  Exercise  Price and the  number of
Warrant Shares after such adjustment or the effect of such modification, a brief
statement of the facts requiring such adjustment or modification  and the manner
of computing the same and cause copies of such  certificate  to be mailed to the
Holders of the Warrants.

         (i) If the Board of Directors of the Company shall declare any dividend
or other  distribution  with respect to the Common Stock, the Company shall mail
notice thereof to the Holders of the Warrants not less than 30 days prior to the
record date fixed for determining  stockholders  entitled to participate in such
dividend or other distribution.

         (j) If, as a result of an  adjustment  made pursuant to this Section 3,
the Holder of any Warrant  thereafter  surrendered  for  exercise  shall  become
entitled to receive  shares of two or more classes of capital stock or shares of
Common  Stock and other  capital  stock of the  Company,  the Board of Directors
(whose  determination  shall be  conclusive  and shall be described in a written
notice to the  Holder of any  Warrant  promptly  after  such  adjustment)  shall
determine  the  allocation of the adjusted Per Share  Exercise  Price between or
among  shares or such  classes  of capital  stock or shares of Common  Stock and
other capital stock.

         (k) For the purpose of any computation  under Section 3 above, the then
Current  Market Price per share (the "CURRENT  MARKET PRICE") shall be deemed to
be the last sale price of the Common Stock on the trading day prior to such date
or, in case no such  reported  sales take place on such day,  the average of the
last  reported  bid and asked  prices of the Common Stock on such day, in either
case on the principal national  securities exchange on which the Common Stock is
admitted  to trading or listed,  or if not listed or  admitted to trading on any
such  exchange,  the  representative  closing  bid price of the Common  Stock as
reported by the National  Association  of  Securities  Dealers,  Inc.  Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined by agreement between the Company's Board of Directors,  on the one
part, and the Holders of Warrants  representing the right to purchase a majority
of the Warrant Shares subject to all outstanding  Warrants,  on the second part.
If the Board of Directors  and such Holders fail to agree on the Current  Market
Price  within 60 days of the date of the action  giving  rise to any  adjustment
pursuant to this Section 3, such Holders  shall be entitled to appoint a firm of
independent  public  accountants or appraisers of recognized  national  standing
reasonably acceptable to the Company,  which shall give their opinion as to such
Current  Market  Price on a basis  consistent  with  the  essential  intent  and
principles  established herein.  Upon receipt of such opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants or appraisers shall be borne by the Company.

         4. REGISTRATION UNDER SECURITIES ACT OF 1933. The resale of the Warrant
Shares shall be  registered on the Shelf  Registration  Statement (as defined in
Article 8 of the Note and Warrant Purchase Agreement (the "Purchase  Agreement")
dated as of January 28, 1997, by and among the Company, The Aries Fund, a Cayman
Island Trust, and The Aries Domestic Fund, L.P., a Delaware limited partnership)
and  certain   purchasers  and  the  Holder  of  this  Warrant  shall  have  the
registration rights as provided in Article 8 of the Purchase  Agreement.  If the
Holder is not a party to the Purchase  Agreement,  by acceptance of this Warrant
the  Holder  agrees to  comply  with  provisions  of  Article 8 of the  Purchase
Agreement to the same extent as if it were a party thereto.

         5. LIMITED TRANSFERABILITY.  This Warrant may not be sold, transferred,
assigned or  hypothecated by the Holder except in compliance with the provisions
of the Act and the  applicable  state  securities  "blue  sky"  laws,  and is so
transferable  only  upon the  books of the  Company  which it shall  cause to be
maintained for such purpose. The Company may treat the registered Holder of this
Warrant as he or it appears on the Company's books 


                               Page 71 of 99 Pages


<PAGE>

at any time as the Holder for all purposes.  The Company shall permit any Holder
of a Warrant  or his duly  authorized  attorney,  upon  written  request  during
ordinary  business  hours,  to inspect and copy or make  extracts from its books
showing  the  registered  holders of  Warrants.  All  Warrants  issued  upon the
transfer  or  assignment  of this  Warrant  will be dated  the same date as this
Warrant, and all rights of the holder thereof shall be identical to those of the
Holder.

         6. LOSS, ETC., OF WARRANT. Upon receipt of evidence satisfactory to the
Company of the loss,  theft,  destruction or mutilation of this Warrant,  and of
indemnity reasonably  satisfactory to the Company, if lost, stolen or destroyed,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall  execute and  deliver to the Holder a new Warrant of like date,  tenor and
denomination.

         7. STATUS OF HOLDER.  This  Warrant does not confer upon the Holder any
right  to vote or to  consent  to or  receive  notice  as a  stockholder  of the
Company, as such, in respect of any matters  whatsoever,  or any other rights or
liabilities as a stockholder, prior to the exercise hereof.

         8. NOTICES.  No notice or other  communication under this Warrant shall
be effective unless,  but any notice or other  communication  shall be effective
and shall be deemed to have been given if, the same is in writing  and is mailed
by first-class mail, postage prepaid, addressed to:

          (a) the  Company  at  3550  General  Atomic  Corporation,  San  Diego,
          California 92121, Attention: Thomas H. Adams, or such other address as
          the Company has designated in writing to the Holder; or

          (b) the Holder at the address  indicated in the notice  provisions  to
          the  Purchase  Agreement,  or other  such  address  as the  Holder has
          designated in writing to the Company.

         9. OPTIONAL  CONVERSION.  Each warrant shall be convertible  into a New
Warrant (as  hereinafter  defined) on a one for one basis.  "New Warrants" shall
mean a new class of warrants  entitling the holders thereof to purchase,  at any
time on or before  the date which is five (5) years  from the date  hereof,  one
share of Common Stock at an exercise price equal to the lesser of (a) $0.15, and
(b) fifty percent (50%) of the average closing bid price of the Common Stock for
either (i) the thirty (30) consecutive  trading days immediately  succeeding the
date of the Required Shareholder Approval, if any (the "Approval Date"), or (ii)
the five (5) consecutive trading days preceding the Approval Date, if any. Other
than the exercise price, the New Warrants shall have the same terms as the Class
A  Warrants.  To the  extent  that  there is no  Required  Shareholder  Approval
necessary the foregoing clause (b) shall be ignored.

         Notwithstanding  the foregoing,  the New Warrants' exercise price shall
be  adjusted at the time of the Final  Closing  Date (as that term is defined in
the Letter between Genta and Paramount  Capital Inc., dated January 28, 1997) if
the exercise price of the Offering  Warrants (as defined below) is less than the
exercise  price of the New  Warrants.  In such event the New  Warrants  exercise
price shall be reduced to equal 50% of the then  current  exercise  price of the
Offering  Warrants (as hereafter  defined).  "Offering  Warrants" shall mean the
warrants  described  in  paragraph  7 of the  Letter  between  the  Company  and
Paramount Capital, Inc. dated January 28, 1997.

         "Required  Shareholder  Approval"  shall  mean  the  authorization  and
approval  by the holders of the Common  Stock of the Company of the  issuance of
the shares of Common Stock underlying the Company's  Senior Secured  Convertible
Bridge Notes, to the extent such authorization is required pursuant to the rules
of the Nasdaq National Market or any other statute, rule or regulation.

         10.  HEADINGS.  The headings of this  Warrant  have been  inserted as a
matter of convenience and shall not affect the construction hereof.

         11.  APPLICABLE LAW. This Warrant shall be governed by and construed in
accordance  with the law of the  State  of New York  without  giving  effect  to
principles of conflicts of law thereof.


                               Page 72 of 99 Pages


<PAGE>

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its Chief  Executive  Officer and its corporate seal to be hereunto  affixed and
attested by its Secretary this January 28, 1997


                                          GENTA INCORPORATED



                                          By: /s/Thomas H. Adams
                                              ----------------------
                                                  Name: Thomas H. Adams
                                                  Title:    Chairman


ATTEST:


/s/
- --------------------
     Secretary



[Corporate Seal]


                                 Page 73 of 99 Pages


<PAGE>

                                  SUBSCRIPTION

         The   undersigned,   ____________________________,   pursuant   to  the
provisions  of the  foregoing  Warrant,  hereby  elects to  exercise  the within
Warrant to the extent of purchasing _____________________ shares of Common Stock
thereunder and hereby makes payment of $_______________ by certified or official
bank check in payment of the exercise price therefor.

Dated:_______________                    Signature:_____________________________

                                         Address:_______________________________


                                   ASSIGNMENT

         FOR  VALUE  RECEIVED   _______________________________________   hereby
sells,  assigns and  transfers  unto  _____________________________________  the
foregoing  Warrant  and all  rights  evidenced  thereby,  and  does  irrevocably
constitute and appoint _____________________________, attorney, to transfer said
Warrant on the books of Genta, Inc.


Dated:_______________                    Signature:_____________________________

                                         Address:______________________________


                               PARTIAL ASSIGNMENT

         FOR  VALUE  RECEIVED   __________________________  hereby  assigns  and
transfers unto _________________________ the right to purchase __________ shares
of the Common  Stock,  no par value per  share,  of Genta,  Inc.  covered by the
foregoing  Warrant,  and a  proportionate  part of said  Warrant  and the rights
evidenced    thereby,    and   does    irrevocably    constitute   and   appoint
__________________________,  attorney,  to transfer that part of said Warrant on
the books of Genta, Inc.


Dated:_______________                    Signature:___________________________

                                         Address:_____________________________


                               Page 74 of 99 Pages

                                      
<PAGE>


                                    EXHIBIT J

THESE  SECURITIES HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933 OR
ANY APPLICABLE STATE  SECURITIES  LAWS. THEY MAY NOT BE SOLD,  OFFERED FOR SALE,
PLEDGED  OR  HYPOTHECATED   OR  OTHERWISE   TRANSFERRED  IN  THE  ABSENCE  OF  A
REGISTRATION  STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES  UNDER SUCH ACT
OR AN EXEMPTION  THEREFROM.  ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE
STATE SECURITIES LAWS.



                               GENTA INCORPORATED


              Class B Bridge Warrant for the Purchase of Shares of
                                  Common Stock


No. CB-1                                                        4,270,000 Shares


         FOR VALUE RECEIVED,  GENTA  INCORPORATED.,  a Delaware corporation (the
"COMPANY"), hereby certifies that THE ARIES DOMESTIC FUND, LP, or its registered
assigns (the "Holder") is entitled to purchase from the Company,  subject to the
provisions of this Warrant (the "Warrant"), at any time commencing upon the date
hereof (the  "INITIAL  EXERCISE  DATE"),  and prior to 5:00 P.M.,  New York City
time, on the date which is five (5) years from the date hereof (the "TERMINATION
DATE"),  4,270,000  fully paid and  non-assessable  shares of the Common  Stock,
$.001 par value, of the Company ("Common Stock"),  at an exercise price equal to
$.55 per share of Common  Stock for an aggregate  exercise  price of TWO MILLION
THREE HUNDRED FORTY EIGHT  THOUSAND FIVE HUNDRED  DOLLARS  ($2,348,500.00)  (the
aggregate purchase price payable for the Warrant Shares hereunder is hereinafter
sometimes referred to as the "AGGREGATE  EXERCISE PRICE").  The number of shares
of Common Stock to be received upon exercise of this Warrant and the price to be
paid for each share of Common Stock are subject to possible adjustment from time
to time as hereinafter set forth. The shares of Common Stock or other securities
or property  deliverable  upon such  exercise  as adjusted  from time to time is
hereinafter sometimes referred to as the "WARRANT SHARES." The exercise price of
a share of Common Stock in effect at any time and as adjusted  from time to time
is hereinafter  sometimes referred to as the "PER SHARE EXERCISE PRICE." The Per
Share Exercise Price is subject to adjustment as  hereinafter  provided;  in the
event of any such adjustment,  the number of Warrant Shares shall be adjusted by
dividing the Aggregate  Exercise Price by the Per Share Exercise Price in effect
immediately after such adjustment.  The Aggregate  Exercise Price is not subject
to adjustment.

         1. EXERCISE OF WARRANT.

         (a) This Warrant may be  exercised in whole or in part,  at any time by
the Holder  commencing on the Initial Exercise Date and prior to the Termination
Date, by  presentation  and  surrender of this  Warrant,  together with the duly
executed  subscription form attached at the end hereof, at the address set forth
in subsection 8(a) hereof,  together with payment, by certified or official bank
check or wire  transfer  payable to the order of the Company,  of the  Aggregate
Exercise Price or the proportionate part thereof if exercised in part.

         (b) If this Warrant is exercised in part only, the Company shall,  upon
presentation of this Warrant upon such exercise, execute and deliver (along with
the certificate for the Warrant Shares  purchased) a new Warrant  evidencing the
rights of the  Holder  hereof to  purchase  the  balance of the  Warrant  Shares
purchasable  hereunder  upon the same terms and  conditions as herein set forth.
Upon  proper  exercise  of this  Warrant,  the Company  promptly  shall  deliver
certificates for the Warrant Shares to the Holder duly legended as authorized by
the subscription  form. No fractional  shares or scrip  representing  fractional
shares shall be issued upon exercise of this Warrant;  provided 


                               Page 75 of 99 Pages


<PAGE>

that the Company  shall pay to the  holders of the Warrant  cash in lieu of such
fractional shares.

         2. RESERVATION OF WARRANT SHARES; FULLY PAID SHARES; TAXES. The Company
hereby  represents that it has, and until expiration of this Warrant agrees that
it shall,  reserve for issuance or delivery upon exercise of this Warrant,  such
number of shares of the Common Stock as shall be required  for  issuance  and/or
delivery  upon  exercise  of this  Warrant in full,  and agrees that all Warrant
Shares so  issued  and/or  delivered  will be  validly  issued,  fully  paid and
non-assessable,  and  further  agrees to pay all taxes and  charges  that may be
imposed upon such issuance and/or delivery.

         3. PROTECTION AGAINST DILUTION.

         (a) In the event the  Company  shall,  at any time or from time to time
after the date of issuance of this  Warrant,  issue or  distribute to all of the
holders of its shares of Common Stock  evidence of its  indebtedness,  any other
securities of the Company or any cash,  property or other assets (any such event
being herein called a "SPECIAL DIVIDEND"), the Per Share Exercise Price shall be
adjusted  by  multiplying  the Per  Share  Exercise  Price  then in  effect by a
fraction,  the  numerator  of which shall be the then  Current  Market Price (as
defined in paragraph  3(k) below) of the Common Stock,  less the Current  Market
Price of the Special  Dividend  issued or distributed in respect of one share of
Common Stock,  and the denominator of which shall be the Current Market Price of
the Common Stock.  Such adjustment  shall be made  successively  whenever such a
record  date  is  fixed.  Such  adjustment  shall  be  made  whenever  any  such
distribution  is made and shall become  effective  immediately  after the record
date  for  the   determination   of   shareholders   entitled  to  receive  such
distribution.

         (b) In case the Company  shall  hereafter  (i) pay a dividend or make a
distribution on its capital stock in shares of Common Stock,  (ii) subdivide its
outstanding  shares  of Common  Stock  into a greater  number of  shares,  (iii)
combine its  outstanding  shares of Common Stock into a smaller number of shares
or (iv)  issue by  reclassification  of its  Common  Stock any shares of capital
stock of the Company,  the number of shares to be delivered upon exercise of any
share of this  Warrant  will be  appropriately  increased  so that each  Warrant
holder  thereafter  will be entitled to receive the number of Common Shares that
such holder would have owned immediately  following such action had such Warrant
been exercised  immediately prior thereto, and the Per Share Exercise Price will
be appropriately  adjusted.  An adjustment made pursuant to this subsection 3(b)
shall  become  effective  immediately  after  the  record  date in the case of a
dividend  or  distribution  and shall  become  effective  immediately  after the
effective date in the case of a subdivision, combination or reclassification.

         (c)(i) Except as provided in subsections 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share  (determined by dividing (i) the total amount,  if any, received
or  receivable by the Company in  consideration  of the issuance or sale of such
securities plus the consideration,  if any, payable to the Company upon exercise
or conversion  thereof  (collectively,  the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of Common  Stock  issued,  sold or  issuable  upon
exercise or conversion of such  securities)  which is less than the then Current
Market  Price of the Common  Stock (as defined  below) but not below the current
Per Share Exercise Price (which event is governed by subsection  3(c)(ii)),  the
Per Share  Exercise  Price shall be adjusted as of the date of such  issuance or
sale by  multiplying  the Per Share Exercise Price then in effect by a fraction,
the  numerator  of which  shall be (x) the sum of (A) the  number  of  shares of
Common Stock  outstanding  on the record date of such  issuance or sale plus (B)
the Total Consideration divided by the Current Market Price of the Common Stock,
and the  denominator  of which shall be (y) the number of shares of Common Stock
outstanding  on the record date of such issuance or sale plus the maximum number
of additional  shares of Common Stock issued,  sold or issuable upon exercise or
conversion of such securities.

         (c)(ii) Except as provided in subsection 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or


                               Page 76 of 99 Pages


<PAGE>

securities  convertible into Common Stock, in each case for a price per share or
entitling the holders thereof to purchase Common Stock at a price per share (the
"ISSUE PRICE"),  (determined by dividing (i) the Total Consideration by (ii) the
number of additional shares of Common Stock issuable upon exercise or conversion
of such securities) which is less than the then current Per Share Exercise Price
in effect on the record  date of such  issuance,  the Per Share  Exercise  Price
shall be adjusted to equal the Issue Price.

         (d) In the event of any capital reorganization or reclassification,  or
any  consolidation or merger to which the Company is a party other than a merger
or consolidation in which the Company is the continuing corporation,  or in case
of any sale or conveyance to another entity of the property of the Company as an
entirety  or  substantially  as an  entirety,  or in the  case of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Warrant  shall have the right  thereafter  to receive on the exercise of
this Warrant the kind and amount of securities, cash or other property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had this Warrant been  exercised  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 3 with respect to the rights and  interests  thereafter of
the  Holder of this  Warrant  to the end that the  provisions  set forth in this
Section 3 shall thereafter  correspondingly be made applicable, as nearly as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  exercise of this  Warrant.  The above
provisions  of  this   subsection  3(e)  shall  similarly  apply  to  successive
reorganizations,    reclassifications,    consolidations,   mergers,   statutory
exchanges,  sales or  conveyances.  The  issuer of any  shares of stock or other
securities or property  thereafter  deliverable  on the exercise of this Warrant
shall be responsible  for all of the  agreements and  obligations of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the  Warrants  not less
than 30 days  prior to such  event.  A sale of all or  substantially  all of the
assets of the Company for a  consideration  consisting  primarily of  securities
shall be deemed a consolidation or merger for the foregoing purposes.

         (e) In case any event shall occur as to which the other  provisions  of
this Section 3 are not strictly  applicable  but as to which the failure to make
any adjustment would not fairly protect the purchase rights  represented by this
Warrant in accordance with the essential  intent and principles  hereof then, in
each such case,  the  Holders of Warrants  representing  the right to purchase a
majority of the Warrant Shares subject to all outstanding Warrants may appoint a
firm  of  independent  public   accountants  of  recognized   national  standing
reasonably  acceptable to the Company,  which shall give their opinion as to the
adjustment,  if  any,  on a basis  consistent  with  the  essential  intent  and
principles  established  herein,  necessary  to  preserve  the  purchase  rights
represented  by the  Warrants.  Upon receipt of such  opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants shall be borne by the Company.

         (f) Whenever the Per Share Exercise Price payable upon exercise of each
Warrant is adjusted  pursuant to this  Section 3, the number of shares of Common
Stock underlying a Warrant shall  simultaneously be adjusted to equal the number
obtained by dividing  the  Aggregate  Exercise  Price by the  adjusted Per Share
Exercise Price.

         (g) No  adjustment  in the Per Share  Exercise  Price shall be required
unless such  adjustment  would require an increase or decrease of at least $0.01
per share of Common Stock;  provided,  however,  that any  adjustments  which by
reason of this  subsection  3(g) are not  required  to be made  shall be carried
forward and taken into account in any subsequent  adjustment.  All  calculations
under this Section 3 shall be made to the nearest cent or to the nearest 1/100th
of a share,  as the case may be.  Anything  in this  Section  3 to the  contrary
notwithstanding,  the Company  shall be entitled to make such  reductions in the
Per Share Exercise Price, in addition to those required by this Section 3, as it
in its discretion  shall deem to be advisable in order that any stock  dividend,
subdivision of shares or  distribution of rights to purchase stock or securities
convertible  or  


                               Page 77 of 99 Pages


<PAGE>

exchangeable for stock hereafter made by the Company to its  stockholders  shall
not be taxable.

         (h)  Whenever the Per Share  Exercise  Price is adjusted as provided in
this Section 3 and upon any  modification  of the rights of a Holder of Warrants
in accordance  with this Section 3, the Company shall  promptly  obtain,  at its
expense, a certificate of a firm of independent public accountants of recognized
standing  selected by the Board of Directors (who may be the regular auditors of
the  Company)  setting  forth the Per  Share  Exercise  Price and the  number of
Warrant Shares after such adjustment or the effect of such modification, a brief
statement of the facts requiring such adjustment or modification  and the manner
of computing the same and cause copies of such  certificate  to be mailed to the
Holders of the Warrants.

         (i) If the Board of Directors of the Company shall declare any dividend
or other  distribution  with respect to the Common Stock, the Company shall mail
notice thereof to the Holders of the Warrants not less than 30 days prior to the
record date fixed for determining  stockholders  entitled to participate in such
dividend or other distribution.

         (j) If, as a result of an  adjustment  made pursuant to this Section 3,
the Holder of any Warrant  thereafter  surrendered  for  exercise  shall  become
entitled to receive  shares of two or more classes of capital stock or shares of
Common  Stock and other  capital  stock of the  Company,  the Board of Directors
(whose  determination  shall be  conclusive  and shall be described in a written
notice to the  Holder of any  Warrant  promptly  after  such  adjustment)  shall
determine  the  allocation of the adjusted Per Share  Exercise  Price between or
among  shares or such  classes  of capital  stock or shares of Common  Stock and
other capital stock.

         (k) For the purpose of any computation  under Section 3 above, the then
Current  Market Price per share (the "CURRENT  MARKET PRICE") shall be deemed to
be the last sale price of the Common Stock on the trading day prior to such date
or, in case no such  reported  sales take place on such day,  the average of the
last  reported  bid and asked  prices of the Common Stock on such day, in either
case on the principal national  securities exchange on which the Common Stock is
admitted  to trading or listed,  or if not listed or  admitted to trading on any
such  exchange,  the  representative  closing  bid price of the Common  Stock as
reported by the National  Association  of  Securities  Dealers,  Inc.  Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined by agreement between the Company's Board of Directors,  on the one
part, and the Holders of Warrants  representing the right to purchase a majority
of the Warrant Shares subject to all outstanding  Warrants,  on the second part.
If the Board of Directors  and such Holders fail to agree on the Current  Market
Price  within 60 days of the date of the action  giving  rise to any  adjustment
pursuant to this Section 3, such Holders  shall be entitled to appoint a firm of
independent  public  accountants or appraisers of recognized  national  standing
reasonably acceptable to the Company,  which shall give their opinion as to such
Current  Market  Price on a basis  consistent  with  the  essential  intent  and
principles  established herein.  Upon receipt of such opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants or appraisers shall be borne by the Company.

         4. REGISTRATION UNDER SECURITIES ACT OF 1933. The resale of the Warrant
Shares shall be  registered on the Shelf  Registration  Statement (as defined in
Article 8 of the Note and Warrant Purchase Agreement (the "Purchase  Agreement")
dated as of January 28, 1997, by and among the Company, The Aries Fund, a Cayman
Island Trust, and The Aries Domestic Fund, L.P., a Delaware limited partnership)
and  certain   purchasers  and  the  Holder  of  this  Warrant  shall  have  the
registration rights as provided in Article 8 of the Purchase  Agreement.  If the
Holder is not a party to the Purchase  Agreement,  by acceptance of this Warrant
the  Holder  agrees to  comply  with  provisions  of  Article 8 of the  Purchase
Agreement to the same extent as if it were a party thereto.

         5. LIMITED TRANSFERABILITY.  This Warrant may not be sold, transferred,
assigned or  hypothecated by the Holder except in compliance with the provisions
of the Act 


                               Page 78 of 99 Pages


<PAGE>

and the applicable state securities "blue sky" laws, and is so transferable only
upon the books of the  Company  which it shall cause to be  maintained  for such
purpose. The Company may treat the registered Holder of this Warrant as he or it
appears on the Company's  books at any time as the Holder for all purposes.  The
Company  shall permit any Holder of a Warrant or his duly  authorized  attorney,
upon written request during ordinary business hours, to inspect and copy or make
extracts from its books showing the registered holders of Warrants. All Warrants
issued upon the  transfer or  assignment  of this Warrant will be dated the same
date as this Warrant, and all rights of the holder thereof shall be identical to
those of the Holder.

         6. LOSS, ETC., OF WARRANT. Upon receipt of evidence satisfactory to the
 Company of the loss, theft, destruction or mutilation of this Warrant, and of
indemnity reasonably  satisfactory to the Company, if lost, stolen or destroyed,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall  execute and  deliver to the Holder a new Warrant of like date,  tenor and
denomination.

         7. STATUS OF HOLDER.  This  Warrant does not confer upon the Holder any
right  to vote or to  consent  to or  receive  notice  as a  stockholder  of the
Company, as such, in respect of any matters  whatsoever,  or any other rights or
liabilities as a stockholder, prior to the exercise hereof.

         8. NOTICES.  No notice or other  communication under this Warrant shall
be effective unless,  but any notice or other  communication  shall be effective
and shall be deemed to have been given if, the same is in writing  and is mailed
by first-class mail, postage prepaid, addressed to:

          (a) the  Company  at  3550  General  Atomic  Corporation,  San  Diego,
          California 92121, Attention: Thomas H. Adams, or such other address as
          the Company has designated in writing to the Holder; or

          (b) the Holder at the address  indicated in the notice  provisions  to
          the  Purchase  Agreement,  or other  such  address  as the  Holder has
          designated in writing to the Company.

         9. OPTIONAL  CONVERSION.  Each warrant shall be convertible  into a New
Warrant (as  hereinafter  defined) on a one for one basis.  "New Warrants" shall
mean a new class of warrants  entitling the holders thereof to purchase,  at any
time on or before  the date which is five (5) years  from the date  hereof,  one
share of Common Stock at an exercise price equal to the lesser of (a) $0.15, and
(b) fifty percent (50%) of the average closing bid price of the Common Stock for
either (i) the thirty (30) consecutive  trading days immediately  succeeding the
date of the Required Shareholder Approval, if any (the "Approval Date"), or (ii)
the five (5) consecutive trading days preceding the Approval Date, if any. Other
than the exercise price, the New Warrants shall have the same terms as the Class
A  Warrants.  To the  extent  that  there is no  Required  Shareholder  Approval
necessary the foregoing clause (b) shall be ignored.

         Notwithstanding  the foregoing,  the New Warrants' exercise price shall
be  adjusted at the time of the Final  Closing  Date (as that term is defined in
the Letter between Genta and Paramount  Capital Inc., dated January 28, 1997) if
the exercise price of the Offering  Warrants (as defined below) is less than the
exercise  price of the New  Warrants.  In such event the New  Warrants  exercise
price shall be reduced to equal 50% of the then  current  exercise  price of the
Offering  Warrants (as hereafter  defined).  "Offering  Warrants" shall mean the
warrants  described  in  paragraph  7 of the  Letter  between  the  Company  and
Paramount Capital, Inc. dated January 28, 1997.

         "Required  Shareholder  Approval"  shall  mean  the  authorization  and
approval  by the holders of the Common  Stock of the Company of the  issuance of
the shares of Common Stock underlying the Company's  Senior Secured  Convertible
Bridge Notes, to the extent such authorization is required pursuant to the rules
of the Nasdaq National Market or any other statute, rule or regulation.

         10.  HEADINGS.  The headings of this  Warrant  have been  inserted as a
matter of convenience and shall not affect the construction hereof.


                               Page 79 of 99 Pages


<PAGE>

         11.  APPLICABLE LAW. This Warrant shall be governed by and construed in
accordance  with the law of the  State  of New York  without  giving  effect  to
principles of conflicts of law thereof.

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its Chief  Executive  Officer and its corporate seal to be hereunto  affixed and
attested by its Secretary this January 28, 1997


                                     GENTA INCORPORATED



                                     By: /s/Thomas H. Adams
                                         ----------------------
                                            Name: Thomas H. Adams
                                            Title:    President and CEO


ATTEST:


/s/
- --------------------
     Secretary



[Corporate Seal]


                                 Page 80 of 99 Pages


<PAGE>


                                  SUBSCRIPTION

         The   undersigned,   ____________________________,   pursuant   to  the
provisions  of the  foregoing  Warrant,  hereby  elects to  exercise  the within
Warrant to the extent of purchasing _____________________ shares of Common Stock
thereunder and hereby makes payment of $_______________ by certified or official
bank check in payment of the exercise price therefor.

Dated:_______________                    Signature:_____________________________

                                         Address:_______________________________


                                   ASSIGNMENT

         FOR  VALUE  RECEIVED   _______________________________________   hereby
sells,  assigns and  transfers  unto  _____________________________________  the
foregoing  Warrant  and all  rights  evidenced  thereby,  and  does  irrevocably
constitute and appoint _____________________________, attorney, to transfer said
Warrant on the books of Genta, Inc.


Dated:_______________                    Signature:_____________________________

                                         Address:______________________________


                               PARTIAL ASSIGNMENT

         FOR  VALUE  RECEIVED   __________________________  hereby  assigns  and
transfers unto _________________________ the right to purchase __________ shares
of the Common  Stock,  no par value per  share,  of Genta,  Inc.  covered by the
foregoing  Warrant,  and a  proportionate  part of said  Warrant  and the rights
evidenced    thereby,    and   does    irrevocably    constitute   and   appoint
__________________________,  attorney,  to transfer that part of said Warrant on
the books of Genta, Inc.


Dated:_______________                    Signature:___________________________

                                         Address:_____________________________


                                 Page 81 of 99 Pages

                                       
<PAGE>


                                    EXHIBIT K

THESE  SECURITIES HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933 OR
ANY APPLICABLE STATE  SECURITIES  LAWS. THEY MAY NOT BE SOLD,  OFFERED FOR SALE,
PLEDGED  OR  HYPOTHECATED   OR  OTHERWISE   TRANSFERRED  IN  THE  ABSENCE  OF  A
REGISTRATION  STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES  UNDER SUCH ACT
OR AN EXEMPTION  THEREFROM.  ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE
STATE SECURITIES LAWS.



                               GENTA INCORPORATED


              Class B Bridge Warrant for the Purchase of Shares of
                                  Common Stock


No. CB-2                                                        7,930,000 Shares


         FOR VALUE RECEIVED,  GENTA  INCORPORATED.,  a Delaware corporation (the
"COMPANY"),  hereby  certifies that THE ARIES TRUST,  or its registered  assigns
(the  "Holder")  is  entitled  to  purchase  from the  Company,  subject  to the
provisions of this Warrant (the "Warrant"), at any time commencing upon the date
hereof (the  "INITIAL  EXERCISE  DATE"),  and prior to 5:00 P.M.,  New York City
time, on the date which is five (5) years from the date hereof (the "TERMINATION
DATE"),  7,930,000  fully paid and  non-assessable  shares of the Common  Stock,
$.001 par value, of the Company ("Common Stock"),  at an exercise price equal to
$.55 per share of Common Stock for an aggregate  exercise  price of FOUR MILLION
THREE  HUNDRED SIXTY ONE FIVE HUNDRED  DOLLARS  ($4,361,500.00)  (the  aggregate
purchase price payable for the Warrant Shares hereunder is hereinafter sometimes
referred to as the "AGGREGATE  EXERCISE PRICE").  The number of shares of Common
Stock to be received  upon exercise of this Warrant and the price to be paid for
each share of Common Stock are subject to possible  adjustment from time to time
as  hereinafter  set forth.  The shares of Common Stock or other  securities  or
property  deliverable  upon  such  exercise  as  adjusted  from  time to time is
hereinafter sometimes referred to as the "WARRANT SHARES." The exercise price of
a share of Common Stock in effect at any time and as adjusted  from time to time
is hereinafter  sometimes referred to as the "PER SHARE EXERCISE PRICE." The Per
Share Exercise Price is subject to adjustment as  hereinafter  provided;  in the
event of any such adjustment,  the number of Warrant Shares shall be adjusted by
dividing the Aggregate  Exercise Price by the Per Share Exercise Price in effect
immediately after such adjustment.  The Aggregate  Exercise Price is not subject
to adjustment.

         1. EXERCISE OF WARRANT.

         (a) This Warrant may be  exercised in whole or in part,  at any time by
the Holder  commencing on the Initial Exercise Date and prior to the Termination
Date, by  presentation  and  surrender of this  Warrant,  together with the duly
executed  subscription form attached at the end hereof, at the address set forth
in subsection 8(a) hereof,  together with payment, by certified or official bank
check or wire  transfer  payable to the order of the Company,  of the  Aggregate
Exercise Price or the proportionate part thereof if exercised in part.

         (b) If this Warrant is exercised in part only, the Company shall,  upon
presentation of this Warrant upon such exercise, execute and deliver (along with
the certificate for the Warrant Shares  purchased) a new Warrant  evidencing the
rights of the  Holder  hereof to  purchase  the  balance of the  Warrant  Shares
purchasable  hereunder  upon the same terms and  conditions as herein set forth.
Upon  proper  exercise  of this  Warrant,  the Company  promptly  shall  deliver
certificates for the Warrant Shares to the Holder duly legended as authorized by
the subscription  form. No fractional  shares or scrip  representing  fractional
shares shall be issued upon exercise of this Warrant;  provided that the Company
shall pay to the holders of the Warrant cash in lieu of such fractional shares.


                               Page 82 of 99 Pages


<PAGE>

         2. RESERVATION OF WARRANT SHARES; FULLY PAID SHARES; TAXES. The Company
hereby  represents that it has, and until expiration of this Warrant agrees that
it shall,  reserve for issuance or delivery upon exercise of this Warrant,  such
number of shares of the Common Stock as shall be required  for  issuance  and/or
delivery  upon  exercise  of this  Warrant in full,  and agrees that all Warrant
Shares so  issued  and/or  delivered  will be  validly  issued,  fully  paid and
non-assessable,  and  further  agrees to pay all taxes and  charges  that may be
imposed upon such issuance and/or delivery.

         3. PROTECTION AGAINST DILUTION.

         (a) In the event the  Company  shall,  at any time or from time to time
after the date of issuance of this  Warrant,  issue or  distribute to all of the
holders of its shares of Common Stock  evidence of its  indebtedness,  any other
securities of the Company or any cash,  property or other assets (any such event
being herein called a "SPECIAL DIVIDEND"), the Per Share Exercise Price shall be
adjusted  by  multiplying  the Per  Share  Exercise  Price  then in  effect by a
fraction,  the  numerator  of which shall be the then  Current  Market Price (as
defined in paragraph  3(k) below) of the Common Stock,  less the Current  Market
Price of the Special  Dividend  issued or distributed in respect of one share of
Common Stock,  and the denominator of which shall be the Current Market Price of
the Common Stock.  Such adjustment  shall be made  successively  whenever such a
record  date  is  fixed.  Such  adjustment  shall  be  made  whenever  any  such
distribution  is made and shall become  effective  immediately  after the record
date  for  the   determination   of   shareholders   entitled  to  receive  such
distribution.

         (b) In case the Company  shall  hereafter  (i) pay a dividend or make a
distribution on its capital stock in shares of Common Stock,  (ii) subdivide its
outstanding  shares  of Common  Stock  into a greater  number of  shares,  (iii)
combine its  outstanding  shares of Common Stock into a smaller number of shares
or (iv)  issue by  reclassification  of its  Common  Stock any shares of capital
stock of the Company, the Per Share Exercise Price shall be adjusted to be equal
to a fraction,  the numerator of which shall be the Aggregate Exercise Price and
the  denominator of which shall be the number of shares of Common Stock or other
capital stock of the Company  issuable  upon  exercise of this Warrant  assuming
this Warrant had been exercised  immediately prior to such action. An adjustment
made pursuant to this subsection 3(b) shall become effective  immediately  after
the  record  date in the case of a dividend  or  distribution  and shall  become
effective  immediately  after the effective  date in the case of a  subdivision,
combination or reclassification.

         (c)(i) Except as provided in subsections 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share  (determined by dividing (i) the total amount,  if any, received
or  receivable by the Company in  consideration  of the issuance or sale of such
securities plus the consideration,  if any, payable to the Company upon exercise
or conversion  thereof  (collectively,  the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of Common  Stock  issued,  sold or  issuable  upon
exercise or conversion of such  securities)  which is less than the then Current
Market  Price of the Common  Stock (as defined  below) but not below the current
Per Share Exercise Price (which event is governed by subsection  3(c)(ii)),  the
Per Share  Exercise  Price shall be adjusted as of the date of such  issuance or
sale by  multiplying  the Per Share Exercise Price then in effect by a fraction,
the  numerator  of which  shall be (x) the sum of (A) the  number  of  shares of
Common Stock  outstanding  on the record date of such  issuance or sale plus (B)
the Total Consideration divided by the Current Market Price of the Common Stock,
and the  denominator  of which shall be (y) the number of shares of Common Stock
outstanding  on the record date of such issuance or sale plus the maximum number
of additional  shares of Common Stock issued,  sold or issuable upon exercise or
conversion of such securities.

         (c)(ii) Except as provided in subsection 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share (the  "ISSUE  PRICE"),  (determined  by  dividing  (i) the Total
Consideration  by (ii) the number of additional  


                               Page 83 of 99 Pages


<PAGE>

shares of Common Stock issuable upon exercise or conversion of such  securities)
which is less than the then  current Per Share  Exercise  Price in effect on the
record date of such issuance,  the Per Share Exercise Price shall be adjusted to
equal the Issue Price.

         (d) In the event of any capital reorganization or reclassification,  or
any  consolidation or merger to which the Company is a party other than a merger
or consolidation in which the Company is the continuing corporation,  or in case
of any sale or conveyance to another entity of the property of the Company as an
entirety  or  substantially  as an  entirety,  or in the  case of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Warrant  shall have the right  thereafter  to receive on the exercise of
this Warrant the kind and amount of securities, cash or other property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had this Warrant been  exercised  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 3 with respect to the rights and  interests  thereafter of
the  Holder of this  Warrant  to the end that the  provisions  set forth in this
Section 3 shall thereafter  correspondingly be made applicable, as nearly as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  exercise of this  Warrant.  The above
provisions  of  this   subsection  3(e)  shall  similarly  apply  to  successive
reorganizations,    reclassifications,    consolidations,   mergers,   statutory
exchanges,  sales or  conveyances.  The  issuer of any  shares of stock or other
securities or property  thereafter  deliverable  on the exercise of this Warrant
shall be responsible  for all of the  agreements and  obligations of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the  Warrants  not less
than 30 days  prior to such  event.  A sale of all or  substantially  all of the
assets of the Company for a  consideration  consisting  primarily of  securities
shall be deemed a consolidation or merger for the foregoing purposes.

         (e) In case any event shall occur as to which the other  provisions  of
this Section 3 are not strictly  applicable  but as to which the failure to make
any adjustment would not fairly protect the purchase rights  represented by this
Warrant in accordance with the essential  intent and principles  hereof then, in
each such case,  the  Holders of Warrants  representing  the right to purchase a
majority of the Warrant Shares subject to all outstanding Warrants may appoint a
firm  of  independent  public   accountants  of  recognized   national  standing
reasonably  acceptable to the Company,  which shall give their opinion as to the
adjustment,  if  any,  on a basis  consistent  with  the  essential  intent  and
principles  established  herein,  necessary  to  preserve  the  purchase  rights
represented  by the  Warrants.  Upon receipt of such  opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants shall be borne by the Company.

         (f) Whenever the Per Share Exercise Price payable upon exercise of each
Warrant is adjusted  pursuant to this  Section 3, the number of shares of Common
Stock underlying a Warrant shall  simultaneously be adjusted to equal the number
obtained by dividing  the  Aggregate  Exercise  Price by the  adjusted Per Share
Exercise Price.

         (g) No  adjustment  in the Per Share  Exercise  Price shall be required
unless such  adjustment  would require an increase or decrease of at least $0.01
per share of Common Stock;  provided,  however,  that any  adjustments  which by
reason of this  subsection  3(g) are not  required  to be made  shall be carried
forward and taken into account in any subsequent  adjustment.  All  calculations
under this Section 3 shall be made to the nearest cent or to the nearest 1/100th
of a share,  as the case may be.  Anything  in this  Section  3 to the  contrary
notwithstanding,  the Company  shall be entitled to make such  reductions in the
Per Share Exercise Price, in addition to those required by this Section 3, as it
in its discretion  shall deem to be advisable in order that any stock  dividend,
subdivision of shares or  distribution of rights to purchase stock or securities
convertible  or  exchangeable  for stock  hereafter  made by the  Company to its
stockholders shall not be taxable.


                               Page 84 of 99 Pages


<PAGE>

         (h)  Whenever the Per Share  Exercise  Price is adjusted as provided in
this Section 3 and upon any  modification  of the rights of a Holder of Warrants
in accordance  with this Section 3, the Company shall  promptly  obtain,  at its
expense, a certificate of a firm of independent public accountants of recognized
standing  selected by the Board of Directors (who may be the regular auditors of
the  Company)  setting  forth the Per  Share  Exercise  Price and the  number of
Warrant Shares after such adjustment or the effect of such modification, a brief
statement of the facts requiring such adjustment or modification  and the manner
of computing the same and cause copies of such  certificate  to be mailed to the
Holders of the Warrants.

         (i) If the Board of Directors of the Company shall declare any dividend
or other  distribution  with respect to the Common Stock, the Company shall mail
notice thereof to the Holders of the Warrants not less than 30 days prior to the
record date fixed for determining  stockholders  entitled to participate in such
dividend or other distribution.

         (j) If, as a result of an  adjustment  made pursuant to this Section 3,
the Holder of any Warrant  thereafter  surrendered  for  exercise  shall  become
entitled to receive  shares of two or more classes of capital stock or shares of
Common  Stock and other  capital  stock of the  Company,  the Board of Directors
(whose  determination  shall be  conclusive  and shall be described in a written
notice to the  Holder of any  Warrant  promptly  after  such  adjustment)  shall
determine  the  allocation of the adjusted Per Share  Exercise  Price between or
among  shares or such  classes  of capital  stock or shares of Common  Stock and
other capital stock.

         (k) For the purpose of any computation  under Section 3 above, the then
Current  Market Price per share (the "CURRENT  MARKET PRICE") shall be deemed to
be the last sale price of the Common Stock on the trading day prior to such date
or, in case no such  reported  sales take place on such day,  the average of the
last  reported  bid and asked  prices of the Common Stock on such day, in either
case on the principal national  securities exchange on which the Common Stock is
admitted  to trading or listed,  or if not listed or  admitted to trading on any
such  exchange,  the  representative  closing  bid price of the Common  Stock as
reported by the National  Association  of  Securities  Dealers,  Inc.  Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined by agreement between the Company's Board of Directors,  on the one
part, and the Holders of Warrants  representing the right to purchase a majority
of the Warrant Shares subject to all outstanding  Warrants,  on the second part.
If the Board of Directors  and such Holders fail to agree on the Current  Market
Price  within 60 days of the date of the action  giving  rise to any  adjustment
pursuant to this Section 3, such Holders  shall be entitled to appoint a firm of
independent  public  accountants or appraisers of recognized  national  standing
reasonably acceptable to the Company,  which shall give their opinion as to such
Current  Market  Price on a basis  consistent  with  the  essential  intent  and
principles  established herein.  Upon receipt of such opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants or appraisers shall be borne by the Company.

         4. REGISTRATION UNDER SECURITIES ACT OF 1933. The resale of the Warrant
Shares shall be  registered on the Shelf  Registration  Statement (as defined in
Article 8 of the Note and Warrant Purchase Agreement (the "Purchase  Agreement")
dated as of January 28, 1997, by and among the Company, The Aries Fund, a Cayman
Island Trust, and The Aries Domestic Fund, L.P., a Delaware limited partnership)
and  certain   purchasers  and  the  Holder  of  this  Warrant  shall  have  the
registration rights as provided in Article 8 of the Purchase  Agreement.  If the
Holder is not a party to the Purchase  Agreement,  by acceptance of this Warrant
the  Holder  agrees to  comply  with  provisions  of  Article 8 of the  Purchase
Agreement to the same extent as if it were a party thereto.

         5. LIMITED TRANSFERABILITY.  This Warrant may not be sold, transferred,
assigned or  hypothecated by the Holder except in compliance with the provisions
of the Act and the  applicable  state  securities  "blue  sky"  laws,  and is so
transferable  only  upon the  books of the  Company  which it shall  cause to be
maintained for such purpose. The Company may treat the registered Holder of this
Warrant as he or it appears on the Company's books 


                               Page 85 of 99 Pages


<PAGE>

at any time as the Holder for all purposes.  The Company shall permit any Holder
of a Warrant  or his duly  authorized  attorney,  upon  written  request  during
ordinary  business  hours,  to inspect and copy or make  extracts from its books
showing  the  registered  holders of  Warrants.  All  Warrants  issued  upon the
transfer  or  assignment  of this  Warrant  will be dated  the same date as this
Warrant, and all rights of the holder thereof shall be identical to those of the
Holder.

         6. LOSS, ETC., OF WARRANT. Upon receipt of evidence satisfactory to the
Company of the loss,  theft,  destruction or mutilation of this Warrant,  and of
indemnity reasonably  satisfactory to the Company, if lost, stolen or destroyed,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall  execute and  deliver to the Holder a new Warrant of like date,  tenor and
denomination.

         7. STATUS OF HOLDER.  This  Warrant does not confer upon the Holder any
right  to vote or to  consent  to or  receive  notice  as a  stockholder  of the
Company, as such, in respect of any matters  whatsoever,  or any other rights or
liabilities as a stockholder, prior to the exercise hereof.

         8. NOTICES.  No notice or other  communication under this Warrant shall
be effective unless,  but any notice or other  communication  shall be effective
and shall be deemed to have been given if, the same is in writing  and is mailed
by first-class mail, postage prepaid, addressed to:

          (a) the  Company  at  3550  General  Atomic  Corporation,  San  Diego,
          California 92121, Attention: Thomas H. Adams, or such other address as
          the Company has designated in writing to the Holder; or

          (b) the Holder at the address  indicated in the notice  provisions  to
          the  Purchase  Agreement,  or other  such  address  as the  Holder has
          designated in writing to the Company.

         9. OPTIONAL  CONVERSION.  Each warrant shall be convertible  into a New
Warrant (as  hereinafter  defined) on a one for one basis.  "New Warrants" shall
mean a new class of warrants  entitling the holders thereof to purchase,  at any
time on or before  the date which is five (5) years  from the date  hereof,  one
share of Common Stock at an exercise price equal to the lesser of (a) $0.15, and
(b) fifty percent (50%) of the average closing bid price of the Common Stock for
either (i) the thirty (30) consecutive  trading days immediately  succeeding the
date of the Required Shareholder Approval, if any (the "Approval Date"), or (ii)
the five (5) consecutive trading days preceding the Approval Date, if any. Other
than the exercise price, the New Warrants shall have the same terms as the Class
A  Warrants.  To the  extent  that  there is no  Required  Shareholder  Approval
necessary the foregoing clause (b) shall be ignored.

         Notwithstanding  the foregoing,  the New Warrants' exercise price shall
be  adjusted at the time of the Final  Closing  Date (as that term is defined in
the Letter between Genta and Paramount  Capital Inc., dated January 28, 1997) if
the exercise price of the Offering  Warrants (as defined below) is less than the
exercise  price of the New  Warrants.  In such event the New  Warrants  exercise
price shall be reduced to equal 50% of the then  current  exercise  price of the
Offering  Warrants (as hereafter  defined).  "Offering  Warrants" shall mean the
warrants  described  in  paragraph  7 of the  Letter  between  the  Company  and
Paramount Capital, Inc. dated January 28, 1997.

         "Required  Shareholder  Approval"  shall  mean  the  authorization  and
approval  by the holders of the Common  Stock of the Company of the  issuance of
the shares of Common Stock underlying the Company's  Senior Secured  Convertible
Bridge Notes, to the extent such authorization is required pursuant to the rules
of the Nasdaq National Market or any other statute, rule or regulation.

         10.  HEADINGS.  The headings of this  Warrant  have been  inserted as a
matter of convenience and shall not affect the construction hereof.

         11.  APPLICABLE LAW. This Warrant shall be governed by and construed in
accordance  with the law of the  State  of New York  without  giving  effect  to
principles of conflicts of law thereof.


                                 Page 86 of 99 Pages

<PAGE>

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its Chief  Executive  Officer and its corporate seal to be hereunto  affixed and
attested by its Secretary this January 28, 1997


                                       GENTA INCORPORATED



                                       By: /s/Thomas H. Adams
                                           ----------------------
                                              Name: Thomas H. Adams
                                              Title:    Chairman


ATTEST:



- --------------------
    Secretary



[Corporate Seal]


                                 Page 87 of 99 Pages


<PAGE>

                                  SUBSCRIPTION

         The   undersigned,   ____________________________,   pursuant   to  the
provisions  of the  foregoing  Warrant,  hereby  elects to  exercise  the within
Warrant to the extent of purchasing _____________________ shares of Common Stock
thereunder and hereby makes payment of $_______________ by certified or official
bank check in payment of the exercise price therefor.

Dated:_______________                    Signature:_____________________________

                                         Address:_______________________________


                                   ASSIGNMENT

         FOR  VALUE  RECEIVED   _______________________________________   hereby
sells,  assigns and  transfers  unto  _____________________________________  the
foregoing  Warrant  and all  rights  evidenced  thereby,  and  does  irrevocably
constitute and appoint _____________________________, attorney, to transfer said
Warrant on the books of Genta, Inc.


Dated:_______________                    Signature:_____________________________

                                         Address:______________________________


                               PARTIAL ASSIGNMENT

         FOR  VALUE  RECEIVED   __________________________  hereby  assigns  and
transfers unto _________________________ the right to purchase __________ shares
of the Common  Stock,  no par value per  share,  of Genta,  Inc.  covered by the
foregoing  Warrant,  and a  proportionate  part of said  Warrant  and the rights
evidenced    thereby,    and   does    irrevocably    constitute   and   appoint
__________________________,  attorney,  to transfer that part of said Warrant on
the books of Genta, Inc.


Dated:_______________                    Signature:___________________________

                                         Address:_____________________________


                              Page 88 of 99 Pages

                              
<PAGE>

                                    EXHIBIT L


                                                                JANUARY 28, 1997

VIA FACSIMILE
(619) 455-2712

GENTA INCORPORATED
3550 GENERAL ATOMICS COURT
SAN DIEGO, CA 92121

DEAR SIRS:

         REFERENCE  IS MADE TO OUR  RECENT  DISCUSSIONS  RELATING  TO A PROPOSED
OFFERING OF UNITS (THE "UNITS")  CONSISTING OF SENIOR SECURED CONVERTIBLE NOTES,
SERIES D PREFERRED  STOCK AND WARRANTS TO BE ISSUED BY GENTA  INCORPORATED  (THE
"COMPANY")  AS  HEREINAFTER  DESCRIBED.  BASED UPON OUR  DISCUSSIONS,  FINANCIAL
MATERIALS WHICH YOU HAVE SUBMITTED TO US AND REPRESENTATIONS WHICH YOU HAVE MADE
TO US  DESCRIBING  THE COMPANY  AND ITS  PRINCIPALS,  THE  PRESENT AND  PROPOSED
BUSINESS  ACTIVITIES OF THE COMPANY AND THE COMPANY'S  OPERATIONS  AND FINANCIAL
CONDITION,  WE HEREBY  CONFIRM OUR  INTEREST IN ACTING AS  PLACEMENT  AGENT (THE
"PLACEMENT  AGENT"),  ON A "BEST EFFORTS" BASIS, OF A PRIVATE PLACEMENT OFFERING
OF THE COMPANY'S  UNITS (THE  "OFFERING"),  UPON THE  FOLLOWING  BASIC TERMS AND
CONDITIONS:

         1. THE  PLACEMENT  AGENT WILL  INTRODUCE  THE  COMPANY  TO  "ACCREDITED
INVESTORS" AS DEFINED IN REGULATION D PROMULGATED  UNDER THE  SECURITIES  ACT OF
1933, AS AMENDED (THE "ACT") FOR THE PURCHASE OF UNITS AND THE COMPANY WILL SELL
DIRECTLY TO SUCH PURCHASERS A MINIMUM OF 25 UNITS (THE "MINIMUM OFFERING") AND A
MAXIMUM OF 75 UNITS  (THE  "MAXIMUM  OFFERING"),  WITH AN OPTION IN FAVOR OF THE
PLACEMENT AGENT TO OFFER UP TO AN ADDITIONAL 50 UNITS TO COVER  OVER-ALLOTMENTS.
EACH  UNIT WILL  CONSIST  OF (A)  $70,000  PRINCIPAL  AMOUNT  OF SENIOR  SECURED
CONVERTIBLE  NOTES (THE "NOTES"),  (B) 3000 SHARES OF SERIES D PREFERRED  STOCK,
STATED VALUE $10.00 PER SHARE,  OF THE COMPANY  (ALSO  REFERRED TO HEREIN AS THE
"PREFERRED  STOCK")  AND (C)  333,334  WARRANTS  (THE  "WARRANTS").  SUBJECT  TO
RESTRICTIONS ON TRANSFERABILITY UNDER APPLICABLE SECURITIES LAWS, THE COMPONENTS
OF THE UNITS WILL BE IMMEDIATELY  SEPARABLE.  THE RIGHTS AND  PREFERENCES OF THE
PREFERRED  STOCK  ARE  SUBSTANTIALLY  AS SET FORTH IN  EXHIBIT  A HERETO.  FOR A
DESCRIPTION OF THE NOTES PLEASE REFER TO EXHIBIT B.

         2. SUBJECT TO MARKET AND OTHER  CONDITIONS  AT THE TIME OF THE OFFERING
CONTEMPLATED  HEREIN,  THE  UNITS  WILL BE  OFFERED  AT  $100,000  PER UNIT (THE
"INITIAL OFFERING PRICE").

         3. AN  ESCROW  AGENT  REASONABLY  ACCEPTABLE  TO THE  COMPANY  SHALL BE
DESIGNATED  BY THE  PLACEMENT  AGENT TO HOLD  SUBSCRIPTIONS  FOR THE  BENEFIT OF
CUSTOMERS  PENDING THE CLOSING OF THE  OFFERING.  THE FINAL  CLOSING DATE OF THE
OFFERING  WILL OCCUR NO LATER THAN  SIXTY  (60) DAYS  FOLLOWING  THE DATE OF THE
OFFERING  MEMORANDUM (THE  "MEMORANDUM"),  SUBJECT TO EXTENSION AT THE OPTION OF
THE  PLACEMENT  AGENT FOR AN  ADDITIONAL  SIXTY  (60) DAYS (THE  "FINAL  CLOSING
DATE").  IN THE EVENT  THAT  VALID  SUBSCRIPTIONS  FOR AT LEAST 25 UNITS ARE NOT
RECEIVED BY THE FINAL CLOSING DATE,  SUBSCRIPTIONS  WILL BE RELEASED FROM ESCROW
AND RETURNED TO CUSTOMERS,  WITH INTEREST.  UPON RECEIPT OF THE MINIMUM OFFERING
AMOUNT,  THE PLACEMENT AGENT MAY HOLD A CLOSING (THE "INITIAL  CLOSING") AND MAY
HOLD SUBSEQUENT  CLOSINGS ON AN INTERIM BASIS UNTIL THE MAXIMUM  OFFERING AMOUNT
(INCLUDING  ANY  OVER-ALLOTMENT  AMOUNT)  HAS BEEN  REACHED  OR UNTIL  THE FINAL
CLOSING DATE, WHICHEVER IS EARLIER.

         4. PENDING COMPLETION OR TERMINATION (PURSUANT TO PARAGRAPH 9 BELOW) OF
THE OFFERING,  THE COMPANY  AGREES THAT IT WILL NOT (A) NEGOTIATE WITH ANY OTHER
PERSON OR ENTITY RELATING TO A POSSIBLE PUBLIC OR PRIVATE  OFFERING OR PLACEMENT
OF ITS  SECURITIES  OR (B)  DISPOSE  OF ANY  ASSETS OF THE  COMPANY  (INCLUDING,
WITHOUT  LIMITATION,  CREATING OR PERMITTING  THE IMPOSITION OF ANY LIENS) OTHER
THAN IN THE ORDINARY COURSE OF BUSINESS.


                               Page 89 of 99 Pages


<PAGE>

         5. THE COMPANY WILL, AS SOON AS PRACTICABLE, BUT NOT LATER THAN 30 DAYS
AFTER THE FINAL CLOSING DATE OR A QUALIFIED  OFFERING (AS DEFINED IN EXHIBIT B),
(A) FILE A SHELF  REGISTRATION  STATEMENT (THE "SHELF  REGISTRATION  STATEMENT")
WITH  RESPECT  TO (I) THE  RESALE OF THE SHARES OF COMMON  STOCK  ISSUABLE  UPON
CONVERSION OF THE PREFERRED STOCK  (INCLUDING THE PREFERRED STOCK UNDERLYING THE
NOTES AND THE BRIDGE  NOTES),  (II) THE  WARRANTS AND (III) THE SHARES OF COMMON
STOCK ISSUABLE UPON EXERCISE OF THE WARRANTS  (INCLUDING THE BRIDGE  WARRANTS OR
THE NEW WARRANTS (AS DEFINED IN EXHIBIT B), AS THE CASE MAY BE)  (TOGETHER,  THE
"REGISTRABLE  CAPITAL STOCK") WITH THE SEC AND USE ITS BEST EFFORTS TO HAVE SUCH
SHELF  REGISTRATION  STATEMENT  DECLARED  EFFECTIVE BY THE SEC PRIOR TO THE DATE
WHICH IS 75 DAYS AFTER THE FINAL  CLOSING DATE (SUBJECT TO PENALTIES FOR FAILURE
TO EFFECT  SUCH  REGISTRATION  IN THE TIME FRAMES  REQUIRED)  AND (B) CAUSE SUCH
SHELF REGISTRATION  STATEMENT TO REMAIN EFFECTIVE UNTIL SUCH DATE AS THE HOLDERS
OF THE  SECURITIES  HAVE  COMPLETED  THE  DISTRIBUTION  DESCRIBED  IN THE  SHELF
REGISTRATION STATEMENT OR AT SUCH TIME THAT SUCH SHARES ARE NO LONGER, BY REASON
OF RULE 144(K) UNDER THE SECURITIES ACT,  REQUIRED TO BE REGISTERED FOR THE SALE
THEREOF BY SUCH HOLDERS.  IF REQUESTED BY THE PLACEMENT AGENT, AND IN ACCORDANCE
WITH APPLICABLE  SECURITIES LAWS, THE SHELF  REGISTRATION  STATEMENT SHALL COVER
THE  DIRECT  SALE OF SUCH  REGISTRABLE  CAPITAL  STOCK  TO THE  HOLDERS  OF SUCH
SECURITIES.  THE  REGISTRABLE  CAPITAL  STOCK  WILL BE  SUBJECT  TO A  STAGGERED
"LOCK-UP" AS MAY BE DEEMED ADVISABLE BY THE PLACEMENT AGENT.

         6. THE PLACEMENT AGENT WILL RECEIVE CASH COMMISSIONS EQUAL TO 9% OF THE
PRICE  OF THE  UNITS  ISSUED  IN THE  OFFERING  (THE  "CASH  COMMISSIONS").  THE
PLACEMENT AGENT MAY, IN ITS DISCRETION, RETAIN OTHER PLACEMENT AGENTS, WHO SHALL
BE MEMBERS IN GOOD STANDING OF THE NATIONAL  ASSOCIATION OF SECURITIES  DEALERS,
INC.  ("NASD"),  TO ACT AS  SELECTED  DEALERS IN PLACING  THE UNITS.  SUCH OTHER
PLACEMENT  AGENTS  WILL  BE  COMPENSATED  BY  THE  PLACEMENT  AGENT  OUT  OF ITS
COMMISSIONS.  THE  COMPANY HAS  ADVISED  THE  PLACEMENT  AGENT THAT NO PERSON IS
ENTITLED,  DIRECTLY OR INDIRECTLY, TO COMPENSATION FROM THE COMPANY FOR SERVICES
AS A FINDER IN CONNECTION  WITH THE PROPOSED  OFFERING OR ANY OTHER  TRANSACTION
CONTEMPLATED BY THIS LETTER OF INTENT.

         7. EACH WARRANT  ENTITLES THE HOLDER  THEREOF TO PURCHASE,  AT ANY TIME
OVER A FIVE YEAR PERIOD ONE SHARE OF COMMON STOCK AT AN EXERCISE  PRICE EQUAL TO
THE LESSER OF (A) $.30 PER SHARE AND (B) 50% OF THE AVERAGE CLOSING BID PRICE OF
THE COMMON STOCK FOR EITHER (I) THE THIRTY CONSECUTIVE  TRADING DAYS IMMEDIATELY
PRECEDING ANY CLOSING DATE OR (II) THE FIVE CONSECUTIVE TRADING DAYS IMMEDIATELY
PRECEDING ANY CLOSING DATE,  WHICHEVER IS THE LOWEST. THE WARRANT EXERCISE PRICE
IS SUBJECT TO ANTIDILUTION  ADJUSTMENTS UNDER CERTAIN  CUSTOMARY  CIRCUMSTANCES,
INCLUDING BELOW MARKET AND/OR EXERCISE PRICE ISSUANCES. THE WARRANTS ARE SUBJECT
TO  REDEMPTION  BY THE COMPANY AT $.01 PER SHARE FOR EACH SHARE  SUBJECT TO EACH
WARRANT  ON 60  DAYS'  PRIOR  WRITTEN  NOTICE,  PROVIDED  THAT THE  CLOSING  BID
QUOTATION FOR THE COMMON STOCK AS REPORTED ON THE NASDAQ, OR ON SUCH EXCHANGE ON
WHICH THE COMMON  STOCK IS THEN TRADED OR LISTED,  EXCEEDS  300% OF THE EXERCISE
PRICE PER SHARE FOR 20  CONSECUTIVE  TRADING DAYS ENDING THREE DAYS PRIOR TO THE
DATE OF THE NOTICE OF REDEMPTION. THE WARRANTS ARE NOT REDEEMABLE ON OR PRIOR TO
THE FIRST ANNIVERSARY OF THEIR ISSUANCE OR AT ANY TIME THAT ANY SHARES OF SERIES
A  PREFERRED  STOCK  REMAIN  OUTSTANDING.  NOTWITHSTANDING  THE  FOREGOING,  THE
WARRANTS ARE REDEEMABLE AFTER THE FIRST ANNIVERSARY REGARDLESS OF WHETHER ANY OR
ALL OF THE SERIES A  PREFERRED  STOCK  REMAINS  OUTSTANDING  IF THE  CLOSING BID
QUOTATION FOR THE COMMON STOCK AS REPORTED ON THE NASDAQ, OR ON SUCH EXCHANGE ON
WHICH THE COMMON  STOCK IS THEN TRADED OR LISTED,  EXCEEDS  600% OF THE EXERCISE
PRICE PER SHARE FOR 20  CONSECUTIVE  TRADING DAYS ENDING THREE DAYS PRIOR TO THE
DATE OF THE NOTICE OF  REDEMPTION.  THE COMPANY WILL PAY THE  PLACEMENT  AGENT A
COMMISSION OF 5% UPON THE EXERCISE OF ANY OF THE WARRANTS,  THE NEW WARRANTS AND
THE BRIDGE WARRANTS.  THE PLACEMENT AGENT MAY ALLOW A PORTION OF THIS COMMISSION
TO MEMBERS IN GOOD  STANDING OF THE NASD.  ANY COSTS  INCURRED BY THE  PLACEMENT
AGENT IN CONNECTION WITH THE SOLICITATION OF WARRANT EXERCISES OR THE REDEMPTION
OF WARRANTS SHALL BE BORNE BY THE COMPANY.

         8.  PENDING  COMPLETION  OF  THE  OFFERING  AND  FOR  A 30  DAY  PERIOD
THEREAFTER,  THE  COMPANY  WILL NOT  ISSUE  PRESS  RELEASES  OR  ENGAGE IN OTHER
PUBLICITY  WITHOUT  ADVISING THE PLACEMENT  AGENT IN ADVANCE.  THE COMPANY SHALL
MAKE A RULE 135(C) (UNDER THE SECURITIES  ACT OF 1933, AS AMENDED)  ANNOUNCEMENT
PRIOR TO THE  COMMENCEMENT OF THE OFFERING.  DURING THE 18 MONTHS  FOLLOWING THE
CLOSING OF THE BRIDGE LOAN,  THE COMPANY  SHALL NOT,  WITHOUT THE PRIOR  WRITTEN
CONSENT OF THE PLACEMENT AGENT,  OFFER OR SELL ANY OF ITS SECURITIES IN RELIANCE
ON REGULATION S OF THE SECURITIES  ACT OF 1933, AS AMENDED.  DURING THE 18 MONTH
PERIOD FOLLOWING THE CLOSING OF THE BRIDGE LOAN, THE PLACEMENT AGENT


                               Page 90 of 99 Pages


<PAGE>

SHALL HAVE THE RIGHT OF FIRST REFUSAL TO ACT AS PLACEMENT  AGENT FOR THE PRIVATE
OFFERING OF ANY SECURITIES OF THE COMPANY.  DURING THE 36 MONTH PERIOD FOLLOWING
THE CLOSING OF THE BRIDGE LOAN (AS DEFINED IN PARAGRAPH  14 BELOW),  THE COMPANY
WILL NOT EXTEND THE  EXPIRATION  DATE OR LOWER THE  EXERCISE  OR THE  CONVERSION
PRICE OF ANY  OPTIONS,  WARRANTS OR  CONVERTIBLE  SECURITIES,  WITHOUT THE PRIOR
WRITTEN CONSENT OF THE PLACEMENT  AGENT.  DURING THE 5 YEAR PERIOD FOLLOWING THE
CLOSING  OF THE  BRIDGE  LOAN,  THE  PLACEMENT  AGENT  SHALL  HAVE THE  RIGHT TO
DESIGNATE A MAJORITY OF THE  DIRECTORS OR OBSERVERS TO THE BOARD OF DIRECTORS OF
THE  COMPANY;  PROVIDED,  HOWEVER,  THAT IN THE EVENT THAT THE  COMPANY  HAS NOT
OBTAINED  FUTURE  FINANCINGS  (AS DEFINED  BELOW) IN EXCESS OF  $3,500,000 ON OR
BEFORE THE DATE WHICH IS 6 MONTHS  AFTER THE BRIDGE  CLOSING DATE (AS DEFINED IN
EXHIBIT B),  THEN THE  PLACEMENT  AGENT  SHALL HAVE THE RIGHT TO APPOINT  ONLY 2
DIRECTORS OR OBSERVERS  AND THE REMAINDER OF THE  PLACEMENT  AGENT'S  DESIGNATED
DIRECTORS  SHALL RESIGN.  IN ADDITION,  IF THE HOLDERS OF THE SERIES A PREFERRED
STOCK EXERCISE THEIR RIGHT TO APPOINT UP TO 2 ADDITIONAL  DIRECTORS  PURSUANT TO
SECTION 9(C) OF THE RESTATED  CERTIFICATE OF  INCORPORATION  OF THE COMPANY (THE
"RESTATED  CERTIFICATE"),  THEN THE  PLACEMENT  AGENT  SHALL  HAVE THE  RIGHT TO
APPOINT UP TO 2  ADDITIONAL  DIRECTORS  PER  DIRECTOR  APPOINTED BY THE SERIES A
PREFERRED STOCK AND, IF REQUESTED BY THE PLACEMENT  AGENT, THE COMPANY SHALL USE
ITS BEST EFFORTS TO OBTAIN THE  RESIGNATIONS  FROM THE BOARD OF DIRECTORS OF ANY
DIRECTORS  SPECIFIED BY THE PLACEMENT  AGENT. THE COMPANY SHALL NOT USE THE NAME
OF THE PLACEMENT AGENT OR ANY OFFICER, DIRECTOR, EMPLOYEE OR SHAREHOLDER WITHOUT
THE EXPRESS WRITTEN CONSENT OF THE PLACEMENT AGENT AND SUCH PERSON.

         "FUTURE  FINANCINGS"  SHALL MEAN THE  AGGREGATE  GROSS  PROCEEDS OF ANY
SALES OF EQUITY  SECURITIES  OF THE  COMPANY  (INCLUDING  THE NOTES OR ANY OTHER
SECURITIES CONVERTIBLE INTO EQUITY SECURITIES OF THE COMPANY), AND THE AGGREGATE
GROSS PROCEEDS OF ANY CORPORATE PARTNERING OR CORPORATE LICENSING  TRANSACTIONS,
BUT SHALL  EXCLUDE THE SALE OF PRODUCTS IN THE  ORDINARY  COURSE OF BUSINESS AND
REVENUES  RESULTING  FROM ANY AGREEMENT IN EFFECT AS OF THE BRIDGE CLOSING DATE.
WITHOUT  LIMITING  THE  GENERALITY  OF  THE  FOREGOING,  SUCH  FUTURE  FINANCING
INCLUDES: (A) ALL PAYMENTS MADE FOR EQUITY SECURITIES, EQUITY SECURITY RIGHTS OR
SIMILAR RIGHTS,  (B) TECHNOLOGY  ACQUISITION OR ACCESS FEES OR SIMILAR  UP-FRONT
PAYMENTS,  (C) OTHER FUTURE PAYMENTS TO BE MADE TO THE  CORPORATION,  ANY OF ITS
AFFILIATES OR ITS EMPLOYEES  FOR THE BENEFIT OF THE  CORPORATION,  FOR WHICH THE
PAYOR IS OBLIGATED EITHER  ABSOLUTELY OR UPON THE ATTAINMENT OF MILESTONES,  (D)
FUNDING PROVIDED BY ANY INVESTOR (THROUGH  REIMBURSEMENT OR OTHERWISE)  RELATIVE
TO RESEARCH AND DEVELOPMENT, CLINICAL TRIALS AND RELATED EXPENDITURES,  PROVIDED
THAT  SUCH  WORK  IS  PERFORMED  OR  MANAGED  BY THE  CORPORATION  OR ANY OF ITS
AFFILIATES  AND (E) THE REPAYMENT OR ASSUMPTION BY ANY PARTY OF  OBLIGATIONS  OF
THE CORPORATION ANY OF ITS AFFILIATES, INCLUDING INDEBTEDNESS FOR MONEY BORROWED
OR AMOUNTS  OWED BY THE  CORPORATION  OR ANY OF ITS  AFFILIATES  TO INVENTORS OR
OWNERS OF TECHNOLOGY.  IT IS FURTHER UNDERSTOOD THAT FUTURE FINANCINGS SHALL NOT
BE  REDUCED  BY THE  AMOUNT OF ANY  EXPENSES,  FEES,  DISCOUNTS  OR  COMMISSIONS
INCURRED DURING THE UNDERTAKING OF SUCH FINANCING.

         9. THE COMPANY  SHALL BE  RESPONSIBLE  FOR AND SHALL BEAR ALL  EXPENSES
DIRECTLY AND  NECESSARILY  INCURRED IN  CONNECTION  WITH THE PROPOSED  OFFERING,
INCLUDING BUT NOT LIMITED TO, THE COSTS OF PREPARING AND PRINTING THE MEMORANDUM
AND ALL EXHIBITS THERETO;  PREPARING,  PRINTING AND DELIVERING  EXHIBITS THERETO
AND COPIES OF THE PRELIMINARY,  FINAL AND SUPPLEMENTAL PROSPECTUS;  THE COSTS OF
PREPARING,  PRINTING AND FILING WITH THE SECURITIES AND EXCHANGE COMMISSION (THE
"SEC")  THE  SHELF   REGISTRATION   STATEMENT  AND  AMENDMENTS,   POST-EFFECTIVE
AMENDMENTS AND SUPPLEMENTS THERETO; PREPARING,  PRINTING AND DELIVERING EXHIBITS
THERETO  AND  COPIES  OF THE  PRELIMINARY,  FINAL AND  SUPPLEMENTAL  PROSPECTUS;
PREPARING,  PRINTING AND  DELIVERING  ALL SELLING  DOCUMENTS,  INCLUDING BUT NOT
LIMITED TO THE PLACEMENT  AGENCY  AGREEMENT,  SUBSCRIPTION  AGREEMENTS,  WARRANT
AGREEMENTS,  BLUE SKY  MEMORANDUM AND STOCK AND WARRANT  CERTIFICATES;  BLUE SKY
FEES,  FILING FEES AND LEGAL FEES AND DISBURSEMENTS OF OUR COUNSEL IN CONNECTION
WITH BLUE SKY MATTERS; FEES AND DISBURSEMENTS OF THE TRANSFER AND WARRANT AGENT;
THE COST OF A TOTAL OF TWO SETS OF BOUND CLOSING VOLUMES FOR THE PLACEMENT AGENT
AND ITS COUNSEL; AND THE COST OF THREE TOMBSTONE ADVERTISEMENTS, AT LEAST ONE OF
WHICH SHALL BE IN A NATIONAL  BUSINESS  NEWSPAPER AND ONE OF WHICH SHALL BE IN A
MAJOR NEW YORK  NEWSPAPER (OR AT THE PLACEMENT  AGENT'S  OPTION,  40 LUCITE DEAL
MEMENTOS)(COLLECTIVELY,  THE "COMPANY  EXPENSES").  THE COMPANY  AGREES TO USE A
PRINTER DESIGNATED BY THE PLACEMENT AGENT AND WHICH IS REASONABLY  ACCEPTABLE TO
THE COMPANY.  THE COMPANY  SHALL PAY TO THE  PLACEMENT  AGENT A  NON-ACCOUNTABLE
EXPENSE  ALLOWANCE  EQUAL  TO 4% OF THE  TOTAL  PROCEEDS  OF THE  OFFERING  (THE
"EXPENSE  ALLOWANCE"),  OF  WHICH  $20,000  SHALL  BE DUE AND  PAYABLE  UPON THE
EXECUTION OF THIS LETTER OF INTENT AND OF WHICH ANOTHER $20,000 SHALL BE DUE AND
PAYABLE UPON THE DATE THAT THE  


                               Page 91 of 99 Pages


<PAGE>

MEMORANDUM IS COMPLETED (BOTH OF WHICH $20,000 PAYMENTS SHALL BE CREDITED TO THE
COMPANY AND OFFSET AGAINST THE TOTAL EXPENSE ALLOWANCE DUE THE PLACEMENT AGENT),
TO COVER THE COST OF OUR MAILING,  TELEPHONE,  TELEGRAPH,  TRAVEL, DUE DILIGENCE
MEETINGS AND OTHER SIMILAR  EXPENSES  INCLUDING LEGAL FEES OF OUR COUNSEL (OTHER
THAN LEGAL FEES IN  CONNECTION  WITH BLUE SKY MATTERS AS TO WHICH FEES YOU SHALL
BE RESPONSIBLE). SUCH PREPAID EXPENSE ALLOWANCES SHALL BE NON-REFUNDABLE. IF THE
PROPOSED  FINANCING IS NOT COMPLETED  BECAUSE THE COMPANY PREVENTS IT OR BECAUSE
OF A BREACH BY THE  COMPANY  OF ANY  COVENANTS,  REPRESENTATIONS  OR  WARRANTIES
CONTAINED HEREIN, THE COMPANY SHALL PAY TO THE PLACEMENT AGENT A FEE OF $100,000
(IN ADDITION TO THE COMPANY  EXPENSES FOR WHICH THE COMPANY  SHALL IN ALL EVENTS
REMAIN  LIABLE).  IN ADDITION,  THE COMPANY SHALL BE  RESPONSIBLE  FOR AND SHALL
REIMBURSE THE PLACEMENT  AGENT AND/OR THE  PARTNERSHIP AND THE TRUST (AS DEFINED
IN PARAGRAPH 16 BELOW) FOR ALL COSTS INCURRED IN CONNECTION WITH THE BRIDGE LOAN
(INCLUDING, WITHOUT LIMITATION,  ATTORNEY'S FEES, EXPENSES AND DISBURSEMENTS) IN
AN AGGREGATE AMOUNT NOT TO EXCEED $35,000  PROVIDED,  HOWEVER,  THAT THE $35,000
CAP ON COST REIMBURSEMENT SHALL APPLY ONLY TO THE ACTUAL BRIDGE LOAN TRANSACTION
AND NOT TO ANY COSTS  INCURRED  AS A RESULT OF THE  REGISTRATION  OF  SECURITIES
ACQUIRED IN SUCH  TRANSACTION  UNDER THE FEDERAL AND STATE SECURITIES LAWS WHICH
SUCH COSTS, AS SET FORTH HEREIN, SHALL BE THE RESPONSIBILITY OF THE COMPANY.

         10. UPON THE FINAL CLOSING OF THE SALE OF THE UNITS BEING OFFERED,  THE
COMPANY WILL GRANT TO THE PLACEMENT AGENT AND/OR ITS DESIGNEES (I) WARRANTS (THE
"PLACEMENT  WARRANTS")  TO PURCHASE  ADDITIONAL  UNITS EQUAL TO 10% OF THE UNITS
SOLD IN THE  OFFERING  EXERCISABLE  FOR A PERIOD OF FIVE  YEARS  COMMENCING  SIX
MONTHS AFTER THE FINAL  CLOSING  DATE AT AN EXERCISE  PRICE EQUAL TO 110% OF THE
INITIAL  OFFERING PRICE OF THE UNITS.  THE  SECURITIES  UNDERLYING THE PLACEMENT
WARRANTS  WILL NOT BE SUBJECT  TO  MANDATORY  CONVERSION  OR  REDEMPTION  BY THE
COMPANY NOR WILL THEY BE CALLABLE BY THE COMPANY.  THE PLACEMENT WARRANTS CANNOT
BE TRANSFERRED,  SOLD,  ASSIGNED OR HYPOTHECATED FOR SIX MONTHS EXCEPT THAT THEY
MAY BE  ASSIGNED  IN WHOLE OR IN PART  DURING  SUCH  PERIOD  TO ANY NASD  MEMBER
PARTICIPATING  IN THE OFFERING OR ANY OFFICER OR EMPLOYEE OF THE PLACEMENT AGENT
OR ANY SUCH NASD MEMBER. THE PLACEMENT WARRANTS WILL CONTAIN A CASHLESS EXERCISE
FEATURE,  ANTIDILUTION  PROVISIONS  AND THE  RIGHT  TO HAVE  THE  RESALE  OF THE
SECURITIES  UNDERLYING THE PLACEMENT WARRANTS INCLUDED ON THE SHELF REGISTRATION
STATEMENT.

         11. IF REQUESTED BY THE PLACEMENT  AGENT,  THE COMPANY WILL OBTAIN FROM
THE EXECUTIVE  OFFICERS AND DIRECTORS OF THE COMPANY,  AND WILL USE BEST EFFORTS
TO OBTAIN FROM ITS 5%  STOCKHOLDERS,  AN AGREEMENT  THAT,  FOR A PERIOD OF UP TO
TWENTY-FOUR MONTHS FROM THE CLOSING OF THE OFFERING,  THEY WILL NOT SELL, ASSIGN
OR  TRANSFER  ANY OF  THEIR  SHARES  OF THE  COMPANY'S  SECURITIES  WITHOUT  THE
PLACEMENT AGENT'S PRIOR WRITTEN CONSENT. IN ADDITION,  THE COMPANY WILL COVENANT
TO USE ITS BEST EFFORTS TO OBTAIN THE REQUISITE  SHAREHOLDER APPROVALS NECESSARY
TO CONSUMMATE THE OFFERINGS AND RELATED  TRANSACTIONS  AS  CONTEMPLATED  BY THIS
LETTER OF INTENT AS SOON AS POSSIBLE FOLLOWING THE CLOSING OF THE BRIDGE LOAN.

         12. THE CASH COMMISSIONS, EXPENSES ALLOWANCE AND PLACEMENT AND ADVISORY
WARRANTS  AS SET  FORTH  IN THIS  LETTER  OF  INTENT  WILL  APPLY  TO  INVESTORS
INTRODUCED  TO THE  COMPANY BY THE  PLACEMENT  AGENT WHO  INVEST IN THE  COMPANY
DURING THE TWELVE MONTHS  FOLLOWING  THE FINAL CLOSING DATE OF THE OFFERING.  IN
ADDITION,  UPON THE CLOSING OF THE BRIDGE  LOAN,  THE COMPANY AND THE  PLACEMENT
AGENT WILL ENTER INTO AN ENGAGEMENT  AGREEMENT WHEREBY PARAMOUNT WILL ACT AS THE
COMPANY'S  NON-EXCLUSIVE  FINANCIAL  ADVISOR.  SUCH  ENGAGEMENT  AGREEMENT  WILL
PROVIDE THAT THE PLACEMENT  AGENT RECEIVE A MONTHLY  RETAINER OF $4,000 (MINIMUM
ENGAGEMENT OF TWENTY-FOUR MONTHS),  OUT-OF-POCKET  EXPENSES AND STANDARD SUCCESS
FEES. IN ADDITION,  UPON COMPLETION OF THE OFFERING AND PURSUANT TO THE TERMS OF
SUCH ENGAGEMENT  AGREEMENT,  THE COMPANY WILL SELL TO THE PLACEMENT AGENT AND/OR
ITS DESIGNEES,  FOR $.001 PER WARRANT SHARE,  WARRANTS (THE "ADVISORY WARRANTS")
TO  PURCHASE  ADDITIONAL  UNITS  EQUAL TO 15% OF THE UNITS SOLD IN THE  OFFERING
EXERCISABLE  FOR A PERIOD OF FIVE YEARS  COMMENCING  SIX MONTHS  AFTER THE FINAL
CLOSING DATE AT AN EXERCISE PRICE EQUAL TO 110% OF THE INITIAL  OFFERING  PRICE.
THE SECURITIES UNDERLYING THE ADVISORY WARRANTS WILL NOT BE SUBJECT TO MANDATORY
CONVERSION  OR  REDEMPTION  BY THE  COMPANY  NOR WILL  THEY BE  CALLABLE  BY THE
COMPANY.  THE  ADVISORY  WARRANTS  WILL  CONTAIN A  CASHLESS  EXERCISE  FEATURE,
ANTIDILUTION  PROVISIONS  AND THE RIGHT TO HAVE THE  SECURITIES  UNDERLYING  THE
ADVISORY WARRANTS INCLUDED ON THE SHELF REGISTRATION STATEMENT.

         13.  THE  COMPANY  SHALL  NOT USE ANY  PROCEEDS  FROM THE  OFFERING  TO
REPURCHASE,  REDEEM OR OTHERWISE  ACQUIRE ANY SHARES OF SERIES A PREFERRED STOCK
OR TO REPAY ANY  INDEBTEDNESS  OF THE COMPANY,  INCLUDING BUT NOT LIMITED TO ANY
INDEBTEDNESS  TO CURRENT  


                               Page 92 of 99 Pages


<PAGE>

EXECUTIVE  OFFICERS OR  PRINCIPAL  STOCKHOLDERS  OF THE COMPANY,  BUT  EXCLUDING
ACCOUNTS PAYABLE INCURRED IN THE ORDINARY COURSE. IN ADDITION, THE COMPANY SHALL
NOT FOR A PERIOD OF 5 YEARS FROM THE INITIAL  CLOSING DATE  OPTIONALLY  AGREE TO
REPURCHASE,  REDEEM OR OTHERWISE  ACQUIRE THE SHARES OF SERIES A PREFERRED STOCK
FOR CASH,  INCLUDING,  WITHOUT LIMITATION,  IN THE EVENT OF A FUNDAMENTAL CHANGE
PURSUANT  TO  THE  RESTATED   CERTIFICATE  AS  SUCH  TERM  IS  DEFINED  THEREIN.
ADDITIONALLY,  PROCEEDS FROM THE BRIDGE LOAN RECEIVED BY THE COMPANY MAY BE USED
BY THE COMPANY AS WORKING CAPITAL IN THE ORDINARY COURSE OF BUSINESS.

         14. AS  EXPEDITIOUSLY  AS  PRACTICABLE  FOLLOWING THE EXECUTION OF THIS
LETTER  OF INTENT  BUT NO LATER  THAN  FEBRUARY  7,  1996,  AND  SUBJECT  TO THE
COMPLETION  OF  NECESSARY  CORPORATE  AND LEGAL DUE  DILIGENCE  (AS TO WHICH THE
PLACEMENT  AGENT SHALL BE THE SOLE JUDGE),  THE  PLACEMENT  AGENT SHALL SERVE AS
PLACEMENT AGENT, ON A "BEST EFFORTS" BASIS, OF A PRIVATE  PLACEMENT (THE "BRIDGE
LOAN") OF $3,000,000 OF SENIOR  SECURED  PROMISSORY  NOTES ISSUED BY THE COMPANY
(THE "BRIDGE  NOTES") AND WARRANTS  (THE  "BRIDGE  WARRANTS"),  ON THE TERMS AND
CONDITIONS CONTAINED IN EXHIBIT B HERETO.  SUBJECT TO THE IMMEDIATELY SUCCEEDING
SENTENCE,  IN  CONNECTION  WITH THE BRIDGE LOAN,  THE  PLACEMENT  AGENT SHALL BE
ENTITLED TO: (X) A COMMISSION  EQUAL TO 9% OF THE TOTAL PROCEEDS  RESULTING FROM
THE SALE OF THE BRIDGE  UNITS AND (Y)  WARRANTS TO PURCHASE 10% OF THE SHARES OF
COMMON STOCK UNDERLYING THE BRIDGE WARRANTS AND THE COMPANY SHALL BE RESPONSIBLE
FOR ALL APPLICABLE COMPANY EXPENSES.  THERE SHALL BE NO EXPENSE ALLOWANCE AND NO
ADVISORY WARRANT COMPENSATION IN CONNECTION WITH THE BRIDGE LOAN.

         15. THE PLACEMENT AGENT RECOGNIZES THE COMPANY'S  CONCERNS WITH RESPECT
TO  THE  ANTISENSE  PROGRAM  AND  FUTURE  FINANCING  PRICING  AND  ALTERNATIVES.
ACCORDINGLY,  THE  PLACEMENT  AGENT  AGREES (I) THAT TO THE  EXTENT  ALTERNATIVE
FINANCINGS ARE AVAILABLE  OTHER THAN THE OFFERING AT BETTER TIMING,  PRICING AND
TERMS,  THEN THE PLACEMENT  AGENT SHALL WAIVE ITS RIGHT TO CONDUCT THE OFFERING,
ITS RIGHT TO RECEIVE  COMPENSATION  THEREFOR  AND ITS RIGHT OF FIRST  REFUSAL AS
DESCRIBED IN PARAGRAPH 8 AND (II) TO USE ITS REASONABLE BEST EFFORTS TO MAINTAIN
THE ANTISENSE PROGRAM. IT IS NOT THE CURRENT INTENTION OF THE PLACEMENT AGENT TO
LIQUIDATE THE COMPANY.

         16.  SUBJECT TO THE  COMPLETION  OF NECESSARY  CORPORATE  AND LEGAL DUE
DILIGENCE  AND THE  EXECUTION OF DEFINITIVE  DOCUMENTATION  SATISFACTORY  TO THE
ARIES DOMESTIC FUND, L.P. (THE "PARTNERSHIP") AND THE ARIES TRUST (THE "TRUST"),
IN THEIR SOLE DISCRETION, THE PARTNERSHIP AND THE TRUST SHALL PARTICIPATE IN THE
BRIDGE  LOAN  REFERENCED  IN  PARAGRAPH  14  IN  AN  AGGREGATE  AMOUNT  OF UP TO
$3,000,000  AND  SHALL BE  ENTITLED  TO  REIMBURSEMENT  FOR  COSTS  INCURRED  IN
CONNECTION WITH THE BRIDGE LOAN AS PROVIDED IN PARAGRAPH 9 HEREOF.

         THE  FOREGOING IS ONLY A BRIEF  OUTLINE OF THE PROPOSED  FINANCING  AND
EACH OF THE FOREGOING  TERMS MUST BE INTERPRETED IN THE FORM IN WHICH IT FINALLY
APPEARS IN THE PROPOSED  PLACEMENT  AGENCY AGREEMENT AND RELATED  DOCUMENTS.  WE
WILL,  OF COURSE,  CONTINUE TO CONDUCT OUR DUE  DILIGENCE  INVESTIGATION  OF THE
COMPANY  UNTIL THE OFFERING IS COMPLETED,  AND SUCH DUE DILIGENCE  INVESTIGATION
SHALL, IN ALL EVENTS,  BE SUBJECT TO OUR SATISFACTION AS TO WHICH WE SHALL BE TO
SOLE JUDGE. WHILE IT IS THE INTENTION OF THE PARTIES HERETO THAT THE OFFERING OF
THE  COMPANY'S  UNITS BE MADE,  THIS LETTER  CANNOT IN ANY WAY BE CONSTRUED AS A
COMMITMENT  BY US TO COMPLETE THE PLACEMENT OF THE UNITS AND WE MAY, IN OUR SOLE
JUDGEMENT  AND  DISCRETION,  DETERMINE  AT ANY  TIME  NOT TO  PROCEED  WITH  THE
OFFERING.  THIS LETTER SHALL BE  CONDITIONED  IN ITS ENTIRETY UPON THE EXECUTION
AND DELIVERY OF A SATISFACTORY  PLACEMENT AGENCY  AGREEMENT  BETWEEN THE COMPANY
AND US (AND THIS  LETTER IS NOT TO BE  CONSTRUED  AS SUCH A  CONTRACT  NOR AS AN
AGREEMENT TO ENTER INTO SUCH CONTRACTS) TO BE ENTERED INTO IMMEDIATELY  PRIOR TO
THE TIME OF THE OFFERING AND SHALL BE CONDITIONED FURTHER UPON COMPLIANCE BY THE
COMPANY  WITH THE TERMS  CONTAINED IN THIS LETTER AND IN SUCH  PLACEMENT  AGENCY
AGREEMENT.  NOTWITHSTANDING THE FOREGOING, THE PROVISIONS OF PARAGRAPHS 4, 8 AND
9 HEREOF  SHALL,  HOWEVER,  BE  EFFECTIVE  AND BINDING UPON THE COMPANY UPON THE
EXECUTION HEREOF.


                               Page 93 of 99 Pages


<PAGE>

         IF THE FOREGOING CONFORMS TO YOUR UNDERSTANDING,  PLEASE SIGN, DATE AND
RETURN TO US THE ENCLOSED COPY OF THIS LETTER.

                                       VERY TRULY YOURS,

                                       PARAMOUNT CAPITAL, INC.


                                       BY: /s/Lindsay A. Rosenwald
                                           ---------------------------
                                           LINDSAY A. ROSENWALD, M.D.
                                           CHAIRMAN

THE FOREGOING IS IN CONFORMITY
WITH OUR UNDERSTANDING:

GENTA INCORPORATED


BY: 
    -----------------------
    THOMAS ADAMS
    PRESIDENT AND CHIEF EXECUTIVE OFFICER


FOR PURPOSES OF PARAGRAPHS 9 AND 16 ONLY:

ARIES DOMESTIC FUND, L.P.


BY: 
    -----------------------
    LINDSAY A. ROSENWALD, M.D.
    PRESIDENT, PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.
    GENERAL PARTNER OF ARIES DOMESTIC FUND, L.P.


FOR PURPOSES OF PARAGRAPHS 9 AND 16 ONLY:

THE ARIES TRUST

BY: 
    -----------------------
    LINDSAY A. ROSENWALD, M.D.
    PRESIDENT, PARAMOUNT CAPITAL ASSET MANAGEMENT, INC


                               Page 94 of 99 Pages


<PAGE>

                                                                       EXHIBIT A


               RIGHTS AND PREFERENCES OFSERIES D PREFERRED STOCKTM


SERIES D PREFERRED STOCK

THE COMPANY WILL FILE A CERTIFICATE OF DESIGNATION  DESIGNATING 3,750,000 SHARES
OF PREFERRED STOCK AS SERIES D PREFERRED STOCK (THE "PREFERRED  STOCK").  GIVING
EFFECT TO THE SALE OF THE MINIMUM  OFFERING,  25,000  SHARES OF PREFERRED  STOCK
WILL BE FULLY PAID, VALIDLY ISSUED AND NON-ASSESSABLE. GIVING EFFECT TO THE SALE
OF THE MAXIMUM  OFFERING,  75,000 SHARES OF PREFERRED  STOCK WILL BE FULLY PAID,
VALIDLY ISSUED AND NON-ASSESSABLE. THE STATED VALUE PER SHARE OF PREFERRED STOCK
SHALL BE $10.00.

         VOTING

THE HOLDERS OF THE  PREFERRED  STOCK WILL HAVE THE RIGHT AT ALL  MEETINGS OF THE
STOCKHOLDERS  TO THAT  NUMBER OF VOTES  EQUAL TO THE  NUMBER OF SHARES OF COMMON
STOCK  ISSUABLE  UPON  CONVERSION  OF SUCH  SHARES  AT THE  RECORD  DATE FOR THE
DETERMINATION  OF THE  STOCKHOLDERS  ENTITLED TO VOTE ON SUCH  MATTERS OR, IF NO
SUCH RECORD DATE IS  ESTABLISHED,  AT THE DATE SUCH VOTE IS TAKEN.  AS LONG AS A
MAJORITY OF THE SHARES OF  PREFERRED  STOCK REMAIN  OUTSTANDING,  THE HOLDERS OF
66-2/3% OF THE OUTSTANDING SHARES OF THE PREFERRED STOCK WILL BE ENTITLED TO (I)
APPROVE ANY  SECURITIES  ISSUED BY THE COMPANY  WHICH ARE SENIOR TO OR ON PARITY
WITH THE PREFERRED STOCK WITH RESPECT TO LIQUIDATION OR DIVIDENDS,  (II) APPROVE
ANY  SECURITIES  ISSUED BY THE COMPANY WHICH ARE SENIOR TO THE  PREFERRED  STOCK
WITH RESPECT TO VOTING (EXCEPT FOR CLASS VOTING RIGHTS  REQUIRED BY LAW),  (III)
APPROVE ANY ALTERATION OR CHANGE TO THE RIGHTS, PREFERENCES OR PRIVILEGES OF THE
PREFERRED   STOCK,   (IV)  APPROVE  ANY   LIQUIDATION,   DISSOLUTION,   SALE  OF
SUBSTANTIALLY ALL OF THE ASSETS OF THE COMPANY, (V) APPROVE THE INCORPORATION OF
ANY SUBSIDIARY  COMPANY,  (VI) APPROVE ANY TRANSACTIONS  BETWEEN THE COMPANY AND
ITS  AFFILIATES  AND (VII)  APPROVE THE ISSUANCE OF ANY DEBT  SECURITIES  OF THE
COMPANY IN EXCESS IN THE AGGREGATE OF $50,000.

         DIVIDENDS

THE HOLDERS OF THE  PREFERRED  STOCK SHALL BE ENTITLED TO RECEIVE  DIVIDENDS AS,
WHEN AND IF DECLARED BY THE BOARD OF DIRECTORS  OUT OF FUNDS  LEGALLY  AVAILABLE
THEREFOR. NO DIVIDEND OR DISTRIBUTION,  AS THE CASE MAY BE, SHALL BE DECLARED OR
PAID ON ANY JUNIOR  STOCK  UNLESS THE SAME IS PAID TO THE  PREFERRED  STOCK.  IN
ADDITION, FOLLOWING THE RESET DATE AS DEFINED BELOW, THE PREFERRED STOCK WILL BE
ENTITLED TO A PAYMENT-IN-KIND DIVIDEND OF 10% PER ANNUM, PAYABLE ANNUALLY.

         LIQUIDATION

UPON (I) A  LIQUIDATION,  DISSOLUTION,  OR  WINDING UP OF THE  COMPANY,  WHETHER
VOLUNTARY  OR  INVOLUNTARY  OR  (II)  A  SALE  OR  OTHER  DISPOSITION  OF ALL OR
SUBSTANTIALLY  ALL OF THE ASSETS OF THE COMPANY (A "LIQUIDATION  EVENT"),  AFTER
PAYMENT  OR  PROVISION  FOR  PAYMENT OF THE DEBTS AND OTHER  LIABILITIES  OF THE
COMPANY,  THE  HOLDERS OF THE  PREFERRED  STOCK THEN  OUTSTANDING  WILL FIRST BE
ENTITLED  TO  RECEIVE,  PRO RATA (ON THE  BASIS OF THE  NUMBER  OF SHARES OF THE
PREFERRED  STOCK THEN  OUTSTANDING),  ON A PARI  PASSU  BASIS WITH THE SHARES OF
SERIES A PREFERRED  STOCK AND IN  PREFERENCE  TO THE HOLDERS OF THE COMMON STOCK
AND ANY OTHER SERIES OF PREFERRED  STOCK,  AN AMOUNT PER SHARE EQUAL TO $14 PLUS
ACCRUED BUT UNPAID  DIVIDENDS,  IF ANY.  MERGERS  AND SIMILAR  EVENTS IN WHICH A
MAJORITY OF THE VOTING  CONTROL OF THE COMPANY'S  CAPITAL  STOCK IS  TRANSFERRED
WILL BE TREATED SIMILARLY WITH RESPECT TO THE MERGER CONSIDERATION.

         CONVERSION

THE PREFERRED STOCK WILL BE CONVERTED INTO COMMON STOCK AT AN INITIAL CONVERSION
PRICE  EQUAL TO THE LESSER OF (I) $.30 AND (II) 50% OF THE  AVERAGE  CLOSING BID
PRICE OF THE COMMON STOCK FOR EITHER THE THIRTY CONSECUTIVE  TRADING DAYS OR THE
FIVE CONSECUTIVE  TRADING DAYS (THE "TRADING PRICE")  IMMEDIATELY  PRECEDING (A)
THE INITIAL CLOSING DATE (THE "INITIAL  CLOSING DATE"),  (B) ANY INTERIM CLOSING
DATE (EACH AN "INTERIM  CLOSING DATE") OR (C) THE FINAL CLOSING DATE (THE "FINAL
CLOSING DATE") OF THIS OFFERING,  WHICHEVER IS THE 


                               Page 95 of 99 Pages


<PAGE>

LOWEST,  SUBJECT TO  ADJUSTMENT  AS SET FORTH BELOW (THE  "PREFERRED  CONVERSION
PRICE"), REPRESENTING AN INITIAL CONVERSION RATE OF [].

THE  PREFERRED  STOCK MAY BE  CONVERTED  AT THE OPTION OF THE HOLDER AT ANY TIME
AFTER  THE  INITIAL  ISSUANCE  DATE  OF  THE  PREFERRED  STOCK  FOR  FULLY  PAID
NONASSESSABLE  SHARES OF COMMON STOCK. THE PREFERRED CONVERSION PRICE IS SUBJECT
TO ADJUSTMENT  UPON THE OCCURRENCE OF A MERGER,  REORGANIZATION,  CONSOLIDATION,
RECLASSIFICATION, STOCK DIVIDEND OR STOCK SPLIT WHICH WILL RESULT IN AN INCREASE
OR DECREASE IN THE NUMBER OF SHARES OF
COMMON STOCK OUTSTANDING.

IN ADDITION,  THE CONVERSION PRICE IN EFFECT  IMMEDIATELY PRIOR TO THE DATE THAT
IS 12 MONTHS AFTER THE FINAL  CLOSING  DATE (THE "RESET  DATE") WILL BE ADJUSTED
AND RESET EFFECTIVE AS OF THE RESET DATE IF THE AVERAGE CLOSING PRICE FOR THE 20
CONSECUTIVE  TRADING DAYS  IMMEDIATELY  PRECEDING THE RESET DATE (THE  "12-MONTH
TRADING  PRICE") IS LESS THAN 140% OF THE THEN APPLICABLE  PREFERRED  CONVERSION
PRICE  (A  "RESET  EVENT").  UPON  THE  OCCURRENCE  OF A RESET  EVENT,  THE THEN
APPLICABLE PREFERRED CONVERSION PRICE WILL BE REDUCED TO BE EQUAL TO THE GREATER
OF (I) THE  12-MONTH  TRADING  PRICE  DIVIDED  BY 1.4 AND  (II)  25% OF THE THEN
APPLICABLE PREFERRED CONVERSION PRICE.

         MANDATORY CONVERSION

UNLESS CONVERTED EARLIER,  THE COMPANY HAS THE RIGHT AT ANY TIME AFTER THE RESET
DATE TO CAUSE THE PREFERRED STOCK TO BE CONVERTED, IN WHOLE OR IN PART, ON A PRO
RATA  BASIS,  INTO  SHARES OF COMMON  STOCK ON 60 DAYS'  PRIOR  WRITTEN  NOTICE,
PROVIDED  THAT THE CLOSING BID QUOTATION FOR THE COMMON STOCK AS REPORTED ON THE
NASDAQ,  OR ON SUCH EXCHANGE ON WHICH THE COMMON STOCK IS THEN TRADED OR LISTED,
EXCEEDS 300% OF THE PREFERRED  CONVERSION PRICE FOR 20 CONSECUTIVE  TRADING DAYS
ENDING  THREE  DAYS  PRIOR TO THE DATE OF THE  NOTICE OF  MANDATORY  CONVERSION.
NOTWITHSTANDING  THE  FOREGOING,  THE COMPANY  SHALL NOT HAVE THE RIGHT TO FORCE
SUCH  MANDATORY  CONVERSION  AT ANY TIME ANY SHARES OF SERIES A PREFERRED  STOCK
REMAIN OUTSTANDING.

         MANDATORY REDEMPTION

IF THE COMPANY IS REQUIRED TO REPURCHASE,  REDEEM OR OTHERWISE ACQUIRE SHARES OF
SERIES A PREFERRED STOCK REPRESENTING MORE THAN 5% OF THE AGGREGATE STATED VALUE
OF THE SERIES A  PREFERRED  STOCK THEN THE COMPANY  SHALL  OFFER TO  REPURCHASE,
REDEEM OR OTHERWISE ACQUIRE THE SHARES OF PREFERRED STOCK, ON A PARI PASSU BASIS
WITH THE SERIES A PREFERRED STOCK BASED ON THE RELATIVE LIQUIDATION  PREFERENCES
OF EACH SUCH SERIES OF PREFERRED STOCK. THE COMPANY SHALL REPURCHASE,  REDEEM OR
OTHERWISE  ACQUIRE  THE SHARES OF  PREFERRED  STOCK WITH THE SAME  CONSIDERATION
WHICH IS PAID TO THE HOLDERS OF SERIES A PREFERRED STOCK.


                               Page 96 of 99 Pages


<PAGE>

                                                                       EXHIBIT B


         TERMS OF BRIDGE FINANCING AND SENIOR SECURED CONVERTIBLE NOTES

THE  FOLLOWING IS A SUMMARY OF THE PROPOSED  TERMS OF THE SALE OF  $3,000,000 OF
BRIDGE NOTES (AS DEFINED BELOW) AND BRIDGE  WARRANTS (AS DEFINED BELOW) OF GENTA
INCORPORATED, A DELAWARE CORPORATION (THE "COMPANY") PURSUANT TO A UNIT PURCHASE
AGREEMENT.


ISSUER:              GENTA INCORPORATED, A DELAWARE CORPORATION (THE "COMPANY").

ISSUE:              $3,000,000  AGGREGATE  FACE AMOUNT OF SENIOR  SECURED BRIDGE
                    NOTES  (THE   "BRIDGE   NOTES")  AND  AN  AGGREGATE  OF  (A)
                    [7,800,000]  WARRANTS (THE "CLASS A BRIDGE  WARRANTS") AT AN
                    EXERCISE PRICE OF $.001 AND (B)  [12,200,000]  WARRANTS (THE
                    "CLASS B BRIDGE  WARRANTS")  AN EXERCISE  PRICE EQUAL TO THE
                    LESSER OF THE AVERAGE  CLOSING BID PRICE OF THE COMMON STOCK
                    FOR  EITHER  (I)  THE  THIRTY   CONSECUTIVE   TRADING   DAYS
                    IMMEDIATELY  PRECEDING THE CLOSING OF THE SALE OF THE BRIDGE
                    NOTES  (THE  "BRIDGE  CLOSING  DATE"),   OR  (II)  THE  FIVE
                    CONSECUTIVE  TRADING DAYS  IMMEDIATELY  PRECEDING THE BRIDGE
                    CLOSING  DATE (THE CLASS A BRIDGE  WARRANTS  AND THE CLASS B
                    BRIDGE  WARRANTS  BEING  COLLECTIVELY  REFERRED  TO  AS  THE
                    "BRIDGE WARRANTS").


MINIMUM 
 SUBSCRIPTION
 AMOUNT PER 
 INVESTOR:          $500,000,  SUBJECT TO THE  COMPANY'S  RIGHT TO ACCEPT LESSER
                    AMOUNTS.


INTEREST ON THE
 BRIDGE NOTES:      THE BRIDGE NOTES WILL PAY INTEREST OF 1% PER MONTH. INTEREST
                    SHALL BE PAYABLE AT MATURITY OR UPON DEFAULT OR LIQUIDATION,
                    AS DESCRIBED BELOW. UPON CONVERSION,  ANY ACCRUED BUT UNPAID
                    INTEREST SHALL BE CONVERTED INTO SHARES OF PREFERRED STOCK.


MATURITY:           UNLESS SHAREHOLDER  APPROVAL IS OBTAINED EARLIER, THE BRIDGE
                    NOTES (AND ALL ACCRUED INTEREST THEREON) ARE DUE AND PAYABLE
                    ON THE  EARLIER  OF (I)  SIX (6)  MONTHS  AFTER  THE  BRIDGE
                    CLOSING DATE AND (II) FIVE (5) BUSINESS  DAYS  FOLLOWING THE
                    CLOSING OF THE  COMPLETION OF ANY EQUITY  OFFERING OR SERIES
                    OF  EQUITY  OFFERINGS  WITH  GROSS  PROCEEDS  IN  EXCESS  OF
                    $2,500,000 (A "QUALIFIED OFFERING").


SECURITY:           ON OR PRIOR TO THE BRIDGE  CLOSING  DATE,  THE COMPANY SHALL
                    ENTER  INTO A SECURITY  AGREEMENT  WITH A  COLLATERAL  AGENT
                    REASONABLY  ACCEPTABLE  TO THE PLACEMENT  AGENT  PURSUANT TO
                    WHICH THE  COMPANY  SHALL  GRANT THE  HOLDERS  OF THE BRIDGE
                    NOTES A FIRST LIEN SECURITY INTEREST IN ALL OF THE ASSETS OF
                    THE COMPANY  WHICH THE COMPANY IS NOT  OTHERWISE  RESTRICTED
                    FROM  GRANTING SUCH A SECURITY  INTEREST.  THE COMPANY SHALL
                    TAKE ALL STEPS  NECESSARY TO PERFECT SUCH SECURITY  INTEREST
                    AT THE TIME OF THE BRIDGE  CLOSING  DATE.  THE COMPANY  WILL
                    COVENANT NOT TO CREATE OR PERMIT THE IMPOSITION OF ANY LIENS
                    ON ANY OF ITS ASSETS FROM AND AFTER THE INITIAL CLOSING DATE
                    AND SHALL MAKE SUCH OTHER  REPRESENTATIONS,  WARRANTIES  AND
                    COVENANTS AS REQUESTED BY THE PLACEMENT AGENT.


CONVERSION
UPON SHAREHOLDER
 APPROVAL:          UPON  RECEIPT  OF  THE   REQUISITE   SHAREHOLDER   APPROVALS
                    NECESSARY   TO   CONSUMMATE   THE   OFFERINGS   AND  RELATED
                    TRANSACTIONS AS CONTEMPLATED BY THIS LETTER OF INTENT:

                    (A)  THE BRIDGE NOTES  TOGETHER  WITH THE ACCRUED AND UNPAID
                         INTEREST THEREON SHALL AUTOMATICALLY BECOME CONVERTIBLE
                         INTO PREFERRED STOCK AT AN INITIAL  CONVERSION PRICE OF
                         $5; AND


                               Page 97 of 99 Pages


<PAGE>

                    (B)  EACH  BRIDGE  WARRANT  SHALL  BE  CONVERTED  INTO A NEW
                         WARRANT (AS HEREINAFTER DEFINED).  "NEW WARRANTS" SHALL
                         MEAN A NEW  CLASS OF  WARRANTS  ENTITLING  THE  HOLDERS
                         THEREOF  TO  PURCHASE,  AT ANY  TIME  OVER A FIVE  YEAR
                         PERIOD ONE SHARE OF COMMON  STOCK AT AN EXERCISE  PRICE
                         EQUAL  TO THE  LESSER  OF (X)  $.15  OR (Y)  50% OF THE
                         AVERAGE  CLOSING  BID  PRICE OF THE  COMMON  STOCK  FOR
                         EITHER  (I)  THE  THIRTY   CONSECUTIVE   TRADING   DAYS
                         IMMEDIATELY SUCCEEDING THE DATE OF SHAREHOLDER APPROVAL
                         (THE  "APPROVAL  DATE")  OR (II) THE  FIVE  CONSECUTIVE
                         TRADING DAYS  IMMEDIATELY  PRECEDING  THE APPROVAL DATE
 
                         NOTWITHSTANDING   THE   FOREGOING,   THE  NEW  WARRANTS
                         EXERCISE  PRICE ARE SUBJECT TO AN  ADDITIONAL  ONE TIME
                         RESET ADJUSTMENT AT THE TIME OF THE FINAL CLOSING DATE,
                         IF THE EXERCISE  PRICE OF THE WARRANTS IS LESS THAN THE
                         EXERCISE  PRICE OF THE NEW WARRANTS.  IN SUCH EVENT THE
                         NEW WARRANTS EXERCISE PRICE SHALL BE REDUCED TO EQUAL A
                         50% DISCOUNT TO THE NEW WARRANTS EXERCISE PRICE.


DEFAULT/
 LIQUIDATION:       IN THE EVENT OF ANY DEFAULT (INCLUDING,  WITHOUT LIMITATION,
                    THE FAILURE OF THE  SHAREHOLDERS TO APPROVE THE TRANSACTIONS
                    CONTEMPLATED  BY THIS LETTER OF INTENT OR A  REQUIREMENT  TO
                    REDEEM,  REPURCHASE OR OTHERWISE  ACQUIRE SHARES OF SERIES A
                    PREFERRED STOCK), LIQUIDATION,  DISSOLUTION OR WINDING UP OF
                    THE COMPANY,  WHETHER VOLUNTARY OR INVOLUNTARY,  THE HOLDERS
                    OF  THE  BRIDGE  NOTES  WILL  BE  ENTITLED  TO  RECEIVE  THE
                    AGGREGATE  OUTSTANDING  PRINCIPAL AMOUNT OF SUCH BRIDGE NOTE
                    TOGETHER WITH THE ACCRUED AND UNPAID  INTEREST  THEREON.  IN
                    ADDITION,  UPON SUCH AN EVENT,  THE HOLDERS OF BRIDGE  NOTES
                    SHALL BE ABLE TO CONVERT  10% OF THEIR  NOTES INTO SHARES OF
                    COMMON STOCK AT A CONVERSION PRICE EQUAL TO $.001.


USE OF
 PROCEEDS:          THE COMPANY INTENDS TO USE THE NET PROCEEDS FROM THE SALE OF
                    THE BRIDGE NOTES TO BRIDGE ITS WORKING CAPITAL NEEDS THROUGH
                    SUCH  TIME  AS  IT  CAN   CONSUMMATE   AN  OFFERING  OF  ITS
                    SECURITIES.  THE COMPANY  COVENANTS  AND AGREES THAT IT WILL
                    NOT USE ANY OF THE PROCEEDS TO (I) REPAY ANY INDEBTEDNESS OF
                    THE COMPANY,  INCLUDING BUT NOT LIMITED TO ANY  INDEBTEDNESS
                    TO OFFICERS, EMPLOYEES,  DIRECTORS OR PRINCIPAL STOCKHOLDERS
                    OF THE COMPANY,  BUT EXCLUDING  ACCOUNTS PAYABLE INCURRED IN
                    THE ORDINARY COURSE OR (II) REDEEM,  REPURCHASE OR OTHERWISE
                    ACQUIRE ANY EQUITY SECURITY OF THE COMPANY.


REGISTRATION
 RIGHTS:            IN  THE  EVENT  THAT  A  QUALIFIED  OFFERING  HAS  NOT  BEEN
                    CONSUMMATED  BY THE DATE  WHICH IS 180 DAYS AFTER THE BRIDGE
                    CLOSING  DATE,  THE COMPANY  WILL  IMMEDIATELY  FILE A SHELF
                    REGISTRATION   STATEMENT  (THE   "REGISTRATION   STATEMENT")
                    COVERING THE RESALE OF THE SHARES OF COMMON STOCK UNDERLYING
                    THE PREFERRED STOCK  UNDERLYING THE BRIDGE NOTES, THE BRIDGE
                    WARRANTS  OR THE NEW  WARRANTS,  AS THE CASE MAY BE, AND USE
                    ITS BEST EFFORTS TO EFFECT THE REGISTRATION AND MAINTAIN THE
                    EFFECTIVENESS  OF  SUCH  REGISTRATION  STATEMENT  UNTIL  THE
                    COMPLETION OF THE DISTRIBUTION OF COMMON STOCK  CONTEMPLATED
                    THEREBY. IN THE EVENT THAT THE REGISTRATION STATEMENT IS NOT
                    EFFECTIVE  WITHIN  TWO  HUNDRED  AND TEN  (210)  DAYS OF THE
                    BRIDGE  CLOSING  DATE,  EACH  PURCHASER  OF THE BRIDGE NOTES
                    SHALL RECEIVE ADDITIONAL BRIDGE WARRANTS OR NEW WARRANTS, AS
                    THE CASE MAY BE, EQUAL TO 1.5% OF THE BRIDGE WARRANTS OR THE
                    NEW WARRANTS, AS THE CASE MAY BE, THEN HELD BY THEM FOR EACH
                    DAY  THEREAFTER  UNTIL THE  REGISTRATION  STATEMENT  BECOMES
                    EFFECTIVE.


                               Page 98 of 99 Pages


<PAGE>

TERMS OF THE 
 SENIOR SECURED 
 CONVERTIBLE 
 NOTES:             THE TERMS AND CONDITIONS OF THE SENIOR  SECURED  CONVERTIBLE
                    NOTES (THE  "NOTES")  SHALL BE  SUBSTANTIALLY  EQUIVALENT TO
                    THOSE  OF THE  BRIDGE  NOTES  EXCEPT  THAT  (I) THE  INITIAL
                    CONVERSION  PRICE  OF THE  NOTES  SHALL  BE  $10,  (II)  THE
                    MATURITY  SHALL BE 10 YEARS  FROM THE DATE OF  ISSUANCE  AND
                    (III) THE COMPANY SHALL HAVE THE RIGHT TO FORCE THE NOTES TO
                    BE CONVERTED  INTO  PREFERRED  STOCK AT ANYTIME AFTER ALL OF
                    THE  SHARES  OF SERIES A  PREFERRED  STOCK  SHALL  HAVE BEEN
                    CONVERTED  INTO COMMON STOCK OR OTHER  SECURITIES  JUNIOR TO
                    THE  PREFERRED  STOCK OR HAVE  OTHERWISE  BEEN  RETIRED IN A
                    MANNER  APPROVED  BY  HOLDERS  OF  66-2/3  OF THE  AGGREGATE
                    PRINCIPAL AMOUNT OF THE NOTES AND THE BRIDGE NOTES.




                              Page 99 of 99 Pages

                                      


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