GENTA INCORPORATED /DE/
DEF 14A, 1997-03-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934


Filed by the Registrant [x] 
Filed by a party other than the Registrant [ ] 
Check the appropriate box: 
[ ] Preliminary  Proxy Statement 
[ ] Confidential, for Use of the Commission Only (as permitted by 
    Rule 14a-6(e)(2))
[x] Definitive Proxy Statement 
[ ] Definitive  Additional Materials 
[ ] Soliciting Material Pursuant to ss. 240.a-11(c) or ss. 240.a-12

                               Genta Incorporated
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

                                       N/A
- --------------------------------------------------------------------------------

    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[x]      No fee required

[ ]    Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
       1)    Title of each class of securities to which transaction applies:

             -----------------------------------------------------------------


       2)    Aggregate number of securities to which transaction applies:

             -----------------------------------------------------------------


       3)    Per  unit  price  or other  underlying  value  of  transaction
             computed  pursuant  to  Exchange  Act Rule 0-11 (set forth the
             amount on which the filing fee is calculated  and state how it
             was determined):

             -----------------------------------------------------------------


       4)    Proposed maximum aggregate value of transaction:

             -----------------------------------------------------------------


<PAGE>

       5)   Total fee paid:

            -----------------------------------------------------------------

[ ]    Fee paid previously with preliminary materials.

[ ]    Check box if any part of the fee is offset as provided  by  Exchange  Act
       Rule  0-11(a)(2) and identify the filing for which the offsetting fee was
       paid previously.  Identify the previous filing by registration  statement
       number, or the Form or Schedule and the date of its filing.

       1)       Amount Previously Paid:

                ---------------------------------------------------------------

       2)       Form, Schedule or Registration Statement No.:

                ---------------------------------------------------------------

       3)       Filing Party:

                ---------------------------------------------------------------

       4)       Date Filed:

                ---------------------------------------------------------------


<PAGE>

                                 [Company Logo]


                           3550 GENERAL ATOMICS COURT
                               SAN DIEGO, CA 92121
                                 (619) 455-2700

                                                                 March 14, 1997


Dear Stockholder:

         You are cordially  invited to attend the Annual Meeting of Stockholders
which will be held on April 4, 1997, at 11:00 a.m., at the Hyatt  Regency,  3777
La Jolla Village Drive, La Jolla, California.

         The Board of Directors  unanimously  recommends adoption of a proposal,
referred to in the Proxy Statement, which would effectuate a one for ten reverse
stock split of the Company's  outstanding Common Stock. The Nasdaq Stock Market,
Inc. has  indicated  that shares of Common Stock of the Company will be delisted
from the Nasdaq Stock Market unless a minimum bid price,  which this proposal is
designed to effect,  is achieved.  See "Threat of Nasdaq  Delisting"  on page 4.
Your vote is therefore especially important.

         The formal notice of the Annual  Meeting and the Proxy  Statement  have
been made a part of this invitation.

         After reading the Proxy Statement,  please mark, date, sign and return,
at an early date, the enclosed proxy in the prepaid envelope to ensure that your
shares will be  represented  at the meeting.  If you have any  questions or need
assistance  in voting your shares,  please call our proxy  solicitor,  MacKenzie
Partners, Inc., at (800) 322-2885 or (212) 929-5500 (call collect).

         A copy of the Company's  Form 10-K for the year ended December 31, 1996
is enclosed.

         The Board of Directors and Management look forward to seeing you at the
meeting.

                                                  Sincerely yours,

                                                  /s/ Thomas H. Adams
                                                  -------------------
                                                  Thomas H. Adams, Ph.D.
                                                  Chairman of the Board and
                                                  Chief Executive Officer


<PAGE>



                               GENTA INCORPORATED



                                  ------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD APRIL 4, 1997



                                  ------------

         The  Annual  Meeting  of  Stockholders   ("Annual  Meeting")  of  Genta
Incorporated  (the "Company")  will be held at the Hyatt Regency,  3777 La Jolla
Village  Drive,  La Jolla,  California,  on April 4, 1997 at 11:00 a.m., for the
following purposes:

         1.       To consider  and vote upon a proposal  to amend the  Company's
                  Restated  Certificate of Incorporation to effectuate a one for
                  ten  reverse  stock  split (if  approved,  each ten  shares of
                  outstanding  Common Stock will be converted  into one share of
                  Common  Stock and the  conversion  ratios  of the  outstanding
                  shares of Preferred  Stock will be  commensurately  adjusted),
                  while reducing the authorized number of shares of Common Stock
                  of the Company from 150,000,000 to 70,000,000.

         2.       To elect one Class III director.

         3.       To ratify the  selection of Ernst & Young LLP as the Company's
                  independent auditors.

         4.       To transact  such other  business as may properly  come before
                  the Annual Meeting and any adjournment of the Annual Meeting.

         The Board of Directors has fixed the close of business on March 4, 1997
as the record date for determining the stockholders entitled to notice of and to
vote at the Annual  Meeting  and any  adjournment  thereof.  A complete  list of
stockholders  entitled to vote will be  available at the  Assistant  Secretary's
office, 3550 General Atomics Court, San Diego,  California,  for ten days before
the meeting.

March 14, 1997                             By Order of the Board of Directors,



                                           /s/ Thomas H. Adams
                                           -------------------
                                           Thomas H. Adams, Ph.D.
                                           Chairman of the Board and
                                           Chief Executive Officer

         IT IS IMPORTANT THAT YOUR SHARES ARE REPRESENTED AT THIS MEETING.  EVEN
IF YOU PLAN TO ATTEND IN PERSON, PLEASE PROMPTLY MARK, DATE, SIGN AND RETURN THE
ENCLOSED PROXY. THIS WILL NOT LIMIT YOUR RIGHT TO ATTEND OR VOTE AT THE MEETING.




<PAGE>



                               GENTA INCORPORATED
                           3550 GENERAL ATOMICS COURT
                           SAN DIEGO, CALIFORNIA 92121
                                 (619) 455-2700
                                  ------------

                                 PROXY STATEMENT

                                  ------------

         This Proxy Statement is furnished in connection  with the  solicitation
by the Board of Directors of Genta  Incorporated,  a Delaware  corporation  (the
"Company"), of proxies in the accompanying form to be used at the Annual Meeting
of Stockholders to be held at the Hyatt Regency, 3777 La Jolla Village Drive, La
Jolla, California,  on April 4, 1997 at 11 a.m. and any adjournment thereof (the
"Annual Meeting"). The shares represented by the proxies received in response to
this  solicitation and not revoked will be voted at the Annual Meeting.  A proxy
may be revoked at any time before it is exercised  by filing with the  Secretary
of the Company a written  revocation  or a duly  executed  proxy bearing a later
date or by voting in person at the Annual Meeting.  On the matters coming before
the Annual  Meeting for which a choice has been  specified by a  stockholder  by
means of the ballot on the proxy,  the shares will be voted  accordingly.  If no
choice is  specified,  the shares will be voted FOR the approval of Proposal One
described in this Proxy Statement, FOR the election of the nominee for Class III
director  listed in this Proxy  Statement and FOR the approval of Proposal Three
described in this Proxy Statement.

         Stockholders  of record of the  Company's  Common  Stock  (the  "Common
Stock")  at the  close of  business  on March 4, 1997 (the  "Record  Date")  are
entitled  to notice  of and to vote at the  Annual  Meeting.  As of the close of
business on the Record Date, the Company had  39,991,626  shares of Common Stock
outstanding and entitled to vote. Each holder of Common Stock is entitled to one
vote for each share held as of the Record  Date.  As of the close of business on
the Record  Date,  the Company also had 528,100  shares of Series A  Convertible
Preferred  Stock (the  "Series A Preferred  Stock") and 1,424 shares of Series C
Convertible  Preferred  Stock ("the Series C Preferred  Stock")  outstanding and
entitled to notice of the Annual  Meeting.  Holders of the Series A and Series C
Preferred Stock are not entitled to vote at the Annual Meeting.

         Proposal  One to be approved  will  require the  affirmative  vote of a
majority of the shares of outstanding  Common Stock.  Directors are elected by a
plurality  vote of shares present in person or represented by proxy and entitled
to vote on the  election  of  directors.  Proposal  Three and any other  matters
submitted for stockholder approval at this Annual Meeting will be decided by the
affirmative  vote of a majority of shares  present in person or  represented  by
proxy and entitled to vote on each such matter.  Abstentions with respect to any
matter are treated as shares present or represented and entitled to vote on that
matter and thus have the same effect as negative  votes.  Broker  non-votes  and
other  circumstances  in which proxy authority has been withheld with respect to
any  matter  are not  deemed  to be  present  or  represented  for  purposes  of
determining whether stockholder approval of that matter has been obtained.

         The entire expense of printing, preparing, assembling and mailing proxy
materials  and the cost of soliciting  proxies will be borne by the Company.  In
addition to the  solicitation  of proxies by mail,  solicitation  may be made by
certain  directors,  officers  and other  employees  of the  Company by personal
interview,  telephone, telegram or facsimile. No additional compensation will be
paid to such persons for such solicitation. In addition, the Company


<PAGE>

has retained MacKenzie  Partners,  Inc. to assist in the solicitation of proxies
for an estimated cost not to exceed $10,000,  plus  reimbursement  of reasonable
out-of-pocket  expenses.  MacKenzie  Partners,  Inc.  will solicit  proxies from
individuals,   brokers,   banks,  nominees  and  other  institutional   holders.
Approximately 20 persons will be utilized by MacKenzie  Partners,  Inc. in their
solicitation efforts, which may be made by telephone, facsimile, telegram and in
person.

         The  Company  will  reimburse  brokerage  firms  and  others  for their
reasonable expenses in forwarding solicitation materials to beneficial owners of
the Company's Common Stock and Series A and Series C Preferred Stock.

         This  Proxy  Statement  and the  accompanying  form of proxy  are being
mailed to stockholders on or about March 14, 1997.


                                    IMPORTANT

         PLEASE  MARK,  DATE AND SIGN THE  ENCLOSED  PROXY AND RETURN IT AT YOUR
EARLIEST  CONVENIENCE IN THE ENCLOSED  POSTAGE-PREPAID  RETURN ENVELOPE SO THAT,
WHETHER  YOU INTEND TO BE PRESENT AT THE ANNUAL  MEETING OR NOT,  YOUR SHARES OF
COMMON  STOCK CAN BE VOTED.  THIS WILL NOT LIMIT YOUR RIGHT TO ATTEND OR VOTE AT
THE ANNUAL MEETING.


                                       -2-


<PAGE>

                                  PROPOSAL ONE

   APPROVAL FOR A ONE FOR TEN REVERSE STOCK SPLIT OF THE COMPANY'S OUTSTANDING
  COMMON STOCK AND DECREASE IN THE NUMBER OF AUTHORIZED SHARES OF COMMON STOCK

         The  Company's  Board  of  Directors  has   unanimously   approved  and
recommended  that the  stockholders  of the Company  approve an amendment to the
Company's   Restated   Certificate  of   Incorporation   (the   "Certificate  of
Incorporation"),  to effect a one for ten reverse  stock split of the  Company's
outstanding Common Stock and to reduce the Company's authorized shares of Common
Stock from  150,000,000 to 70,000,000 (the "Reverse Split  Amendment").  If this
proposal is approved,  the Certificate of  Incorporation  will be amended in the
form attached hereto as Exhibit A.

ADVANTAGES

         The Nasdaq Stock Market,  Inc.  ("Nasdaq") has indicated that shares of
Common Stock of the Company will be delisted from the Nasdaq Stock Market unless
a minimum bid price, which this proposal is designed to effect, is achieved. See
"Threat of Nasdaq Delisting" below. The Board of Directors  believes that such a
delisting  could  adversely  affect the  ability of the  Company to attract  new
investors.

         The increase in the portion of authorized shares that would be unissued
after the reverse  stock  split (the  "Increased  Available  Portion of Shares")
could  be used  for any  proper  corporate  purpose  approved  by the  Board  of
Directors of the Company. The Increased Available Portion of Shares will provide
the Company with additional flexibility to issue additional shares in connection
with future financings.  The Company has entered into a Letter of Intent,  dated
January 28, 1997,  with an  investment  banking firm pursuant to which such firm
confirmed its interest in acting as placement  agent, on a "best efforts" basis,
of a private  placement of convertible  preferred stock,  convertible  notes and
warrants to purchase  common  stock for  proceeds  of up to  $7,500,00  (plus an
over-allotment  option),  subject  to  certain  conditions  set  forth  therein.
Additional shares could also be used for employee benefit plans or in connection
with acquisitions by the Company.

DISADVANTAGES

         Because  the  Reverse  Split  Amendment  will  result in the  Increased
Available  Portion of Shares,  it may be  construed  as having an  anti-takeover
effect,  although  neither  the Board of  Directors  nor the  management  of the
Company views this proposal in that perspective.  However, the Company could use
the Increased Available Portion of Shares to frustrate persons seeking to effect
a takeover or otherwise  gain control of the Company by, for example,  privately
placing  shares with  purchasers  who might side with the Board of  Directors in
opposing a hostile  takeover  bid. In  addition,  shares of Common  Stock may be
issued in the event  that the rights  issued in  connection  with the  Company's
Stockholder  Rights  Plan are  exercised.  Shares of Common  Stock could also be
issued to a holder that would thereafter have sufficient  voting power to assure
that any  proposal to amend or repeal the By-Laws or certain  provisions  of the
Certificate of Incorporation  would not receive the requisite vote. Such uses of
the Common  Stock could  render more  difficult,  or  discourage,  an attempt to
acquire control of the Company, if such transaction were opposed by the Board of
Directors.  Further,  the  Increased  Available  Portion of Shares not otherwise
required  to  meet  the  Company's   obligations   under  its   Certificate   of
Incorporation  (including  shares of Common  Stock  which the  Company  could be
required to issue upon an Event of Default under the Senior Secured  Convertible
Bridge Notes issued by the Company in February,  1997 (the "Convertible  Notes")
could be issued by the Company without further stockholder approval, which could
result in further dilution to the holders of Common Stock.

         As of March 5, 1997 there were (i)  39,991,626  shares of Common  Stock
outstanding;  (ii) 528,100 shares of Series A Preferred  Stock,  par value $.001
per share outstanding; (iii) 1,424 shares of Series C Preferred Stock, par value
$.001 per share  outstanding;  (iv) 1,649,302  options  granted and not expired,
cancelled nor exercised;  and (v) warrants granted to purchase 21,557,685 shares
of Common  Stock.  As of March 5,  1997,  pursuant  to the terms of  outstanding
convertible instruments,  options,  warrants and other obligations,  the Company
may be required to issue in the future up to approximately 100,000,000 shares of
Common Stock;  an additional  approximately  300,000,000  shares of Common Stock
might also be issuable upon an Event of Default under the Convertible  Notes. As
the conversion rates and anti-dilution  adjustments of some of these convertible
instruments are influenced by the market price of the Company's  Common Stock at
any given time, the numbers of shares of Common Stock  issuable upon  conversion
of such  instruments will be affected by fluctuations in the market price of the
Company's Common Stock.


                                       -3-


<PAGE>

REQUIRED VOTE

         In order to be adopted, this proposal must receive the affirmative vote
of the holders of a majority of the outstanding shares of Common Stock.

THREAT OF NASDAQ DELISTING

         Since October 22, 1996 the  Company's  Common Stock has been trading at
less than $1.00 per share.  Effective  February 7, 1997,  the  Company's  Common
Stock was removed from the Nasdaq  National  Market  System and began trading on
the Nasdaq SmallCap Market under a conditional  exception from the bid price and
capital surplus requirements of the Nasdaq SmallCap Market. Nasdaq has indicated
that, unless the Company's Common Stock achieves a minimum bid price of at least
$1.50 per share by April 7, 1997,  and maintains a minimum bid price of at least
$1.50 per share for a period of ten consecutive days  thereafter,  the Company's
Common  Stock will be  delisted  from the Nasdaq  SmallCap  Market.  The Company
believes  that,  if the Reverse Split  Amendment is approved,  it can meet these
requirements;  however,  there can be no assurance  that,  even with the reverse
stock  split,  the Company  will be able to  maintain  its listing on the Nasdaq
SmallCap  Market.  To maintain  such Nasdaq  listing,  the Company  will also be
required  to make a public  filing  with the SEC and Nasdaq  evidencing  minimum
capital and surplus of $6,000,000 on or before April 7, 1997.  While the Company
believes that it can meet this capital and surplus level by such date, there can
be no  assurance  that  the  Company  will  succeed  in  timely  achieving  this
requirement.  There can be no  assurance  that  approval  of the  Reverse  Split
Amendment  will succeed in raising the bid price of the  Company's  Common Stock
above $1.50 per share, that such minimum price, if achieved, would be maintained
for the requisite period, or that even if Nasdaq's minimum bid price requirement
were satisfied, the Company's Common Stock would not be delisted from the Nasdaq
SmallCap Market for other reasons.

EXCHANGE OF STOCK CERTIFICATES

         If  the  Reverse   Split   Amendment  is  approved  by  the   Company's
stockholders,  the  Company  will  instruct  its  transfer  agent  to act as its
exchange agent (the "Exchange  Agent") and to act for holders of Common Stock in
implementing the exchange of their certificates.

         Commencing on the effective  date of the Reverse Split  Amendment  (the
"Effective  Date"),  stockholders  will be notified  and  requested to surrender
their certificates  representing shares of Common Stock to the Exchange Agent in
exchange for  certificates  representing  post-reverse  split Common Stock.  One
share of new Common  Stock  will be issued in  exchange  for each ten  presently
issued and outstanding shares of Common Stock.  Beginning on the Effective Date,
each  certificate  representing  shares of the  Company's  Common  Stock will be
deemed  for  all  corporate   purposes  to  evidence   ownership  of  shares  of
post-reverse split Common Stock.


                                       -4-


<PAGE>

LIQUIDATION OF FRACTIONAL SHARES

         No scrip or fractional  certificates  will be issued in connection with
the reverse stock split. Stockholders who would otherwise be entitled to receive
fractional  shares  because  they hold a number  of  shares of Common  Stock not
evenly  divisible by ten will be entitled,  upon surrender to the Exchange Agent
of certificates  representing  such shares,  to receive one additional  share of
Common Stock for any fractional share to which they would otherwise be entitled.
As a result of the reverse  stock split,  stockholders  who now own "round lots"
may hold "odd lots" and, as a result,  may be subject to  increased  transaction
costs on the sale of their Common Stock.

         Stockholders  are  encouraged to surrender  their  certificates  to the
Exchange Agent for certificates  evidencing whole shares of the Common Stock due
them for fractional interests.

FEDERAL INCOME TAX CONSEQUENCES

         The reverse stock split should not result in the recognition of gain or
loss.  The holding  period of the shares of postsplit  Common Stock will include
the stockholder's respective holding periods for the shares of pre-reverse split
Common Stock exchanged  therefor,  provided that the shares of Common Stock were
held as a capital asset. The adjusted basis of the shares of post-reverse  split
Common  Stock  will be the  same  as the  adjusted  basis  of the  Common  Stock
exchanged therefor.

         Although  not free from doubt,  the above  treatment  should also apply
with respect to additional shares received for fractional shares. However, it is
possible  that the  receipt  of  additional  shares  could be  wholly  or partly
taxable. Holders should consult with their own tax advisors.

NO DISSENTER'S RIGHTS

         Under Delaware law, stockholders are not entitled to dissenter's rights
of appraisal with respect to the reverse stock split.

         THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL ONE.


                                       -5-


<PAGE>

                                  PROPOSAL TWO

                              ELECTION OF DIRECTOR

         The Company has three classes of directors serving staggered three-year
terms. Class I and Class II each consist of two directors and Class III consists
of three directors. Currently, there is one director vacancy in Class II and two
director  vacancies in Class III. One Class III director is to be elected at the
Annual  Meeting for a term of three years expiring at the Annual Meeting in 2000
or until such director's  successor  shall have been elected and qualified.  The
other directors of the Company will continue in office for their existing terms,
which expire in 1998 and 1999 for Class I and Class II directors, respectively.

         Unless authority to vote for directors is withheld, the Company intends
that the shares represented by the enclosed proxy will be voted for the election
of Robert E. Klem,  Ph.D, who is currently a member of the Board of Directors of
the Company, and a Class III Director.  In the event such nominee becomes unable
or unwilling to accept  nomination or election,  the shares  represented  by the
enclosed  proxy will be voted for the  election  of such  person as the Board of
Directors may select.  The Board of Directors has no reason to believe that such
nominee will be unable or unwilling to serve.

         The Board of Directors has not  nominated  anyone to fill the two Class
III  Director  vacancies.  Proxies  cannot  be voted for more than one Class III
Director.

         Set forth below is information  regarding the nominee for the Class III
director  and the  continuing  directors  of  Class I and  Class  II,  including
information  furnished by them as to their principal  occupations at present and
for the past five years,  certain  directorships  held by each, their ages as of
February, 1997 and the year in which each became a director of the Company.

         Name                                                          Age
         ----                                                          ---

         CLASS III

Robert E. Klem, Ph.D.  ...............................................  52

Dr.  Klem has been a director  of the  Company  since  February  1991 and a Vice
President of the Company since October 1991. Dr. Klem co-founded JBL Scientific,
Inc. ("JBL"), a wholly owned subsidiary of the Company, in 1973 and, since then,
has  been  Chairman  of the  Board  and  Chief  Technical  Officer  of JBL  with
responsibility for research,  development and marketing activities.  Previously,
Dr. Klem was the Plant Manager for E.I.  DuPont in Victoria,  Texas from 1970 to
1974.  Dr. Klem received his Ph.D. in Organic  Chemistry  from the University of
California at Riverside.

         CLASS I

Thomas H. Adams, Ph.D. ..............................................   54

Dr. Adams was the founder of the Company and has been  Chairman of the Board and
Chief Executive Officer of the Company since February 1989. He previously served
as Chairman of the Board and Chief Executive  Officer of Gen-Probe  Incorporated
("Gen-Probe"),  which he co-founded in 1984. Prior to joining Gen-Probe, he held
the  positions  of Senior Vice  President  of Research &  Development  and Chief
Technical Officer at Hybritech Incorporated ("Hybritech"),  a leading monoclonal
antibody  products  company which was acquired by Eli Lilly and Company in 1986.
He had previously  held senior  scientific  management  positions with Technicon
Instruments  Corp., the Hyland  Laboratories  Division of Baxter  Travenol,  and
DuPont.  Dr. Adams is a director of Life  Technologies,  Inc.,  a life  sciences
company,  and three  private  biotechnology  firms.  He  received  his Ph.D.  in
Biochemistry from the University of California at Riverside.

Sharon B. Webster, Ph.D.  ..........................................   59

Dr. Webster has been a director of the Company since February 1989. She has been
President,  Chief Executive Officer, Chairman of the Board and Managing Director
of A. A. Global, Inc., a consulting firm, since 1989. From 1988 to 1989,


                                       -6-


<PAGE>

she was a financial  consultant at Shearson Lehman Hutton Inc. From 1983 to 1988
Dr. Webster was an investment banker and account executive at Johnston,  Lemen &
Co.  Inc.  She  received  her Ph.D.  in  International  Political  and  Economic
Relations from the University of Virginia.

         CLASS II

Paul O.P. Ts'o, Ph.D.  .............................................   67

Dr.  Ts'o has been a director  of the Company  since its  inception  in February
1988. Dr. Ts'o is currently Professor of Biophysics,  Department of Biochemistry
at The Johns Hopkins University ("Johns Hopkins"). Dr. Ts'o has been a professor
at Johns Hopkins since 1967, and was Director of the Division of Biophysics from
1973 to 1990. He received his Ph.D. from the California Institute of Technology.

         The Board of Directors held 27 meetings  during the year ended December
31,  1996.  All  directors  attended  at least  75% of the  aggregate  number of
meetings of the Board of Directors and of the committees on which such directors
had  served.  Directors  receive no fees for their  services,  but  non-employee
directors  are  eligible  for stock  options  (see  "Compensation  of  Executive
Officers and Directors -- Compensation of Directors").

         By letter dated October 8, 1996, James C. Blair,  Ph.D.  announced that
he would  be  resigning  as a  Director  and as Vice  Chairman  of the  Board of
Directors of the Company,  effective immediately.  Dr. Blair cited as the reason
for the  resignation  his perception that his views regarding the proper program
to  resolve  the  financial  and  strategic  issues  faced by the  Company  were
irreconcilably  different from those held by the Company's Chairman of the Board
of Directors and by a majority of the Company's Board of Directors.

         Effective  as of the close of business on October 22,  1996,  Samuel D.
Colella  resigned  from the Company's  Board of  Directors.  Effective as of the
close of business on January 28, 1997, David F. Hale resigned from the Company's
Board of Directors. Neither cited a reason.

         The Board of Directors appointed an Executive Committee, a Compensation
Committee,  a Stock  Plan  Committee,  and an  Audit  Committee  in 1995 and the
designated members of such committees were designated to continue to serve until
such members'  respective  successors are duly designated and qualified or until
such members' earlier resignation or removal.

         The  Company  does  not  have  a  standing  Nominating  Committee.  The
functions  customarily  performed by a nominating committee are performed by the
Board of Directors as a whole.  Any  stockholder who wishes to make a nomination
at an  annual  or  special  meeting  for  election  of  directors  must do so in
compliance  with the applicable  procedures set forth in the Company's  By-laws.
The Company will furnish copies of such By-law provision upon written request to
the Company,  Attention:  Investor Relations,  at the offices of the Company, at
3550 General Atomics Court, San Diego, California 92121.

          The members of the Executive  Committee were Thomas H. Adams, James C.
Blair, David F. Hale and Samuel D. Colella.  The Executive  Committee held three
meetings during 1996. Subject to the ultimate direction and control of the Board
of Directors,  the Executive  Committee's function is to exercise,  with certain
exceptions,  all of the powers and  authority  of the Board of  Directors in the
management of the business and affairs of the Company.

         The members of the Stock Plan  Committee  were James C. Blair and David
F. Hale.  The Stock Plan  Committee held one meeting during 1996. The Stock Plan
Committee's  functions are to supervise the administration of, and grant options
under, the 1991 Stock Plan of the Company (the "1991 Stock Plan").

          The members of the Compensation  Committee were Thomas H. Adams, James
C. Blair and David F. Hale. The  Compensation  Committee held one meeting during
1996. The  compensation  of the officers was not addressed at this meeting.  The
Compensation  Committee's  functions are to assist in the implementation of, and
provide  recommendations  with  respect to,  general and  specific  compensation
policies and practices of the Company.

          The members of the Audit  Committee  were  Thomas H.  Adams,  James C.
Blair and  Samuel D.  Colella.  The Audit  Committee  did not hold any  meetings
during  1996.  The Audit  Committee's  functions  are to review the scope of the
annual


                                       -7-


<PAGE>

audit, monitor the independent auditor's  relationship with the Company,  advise
and assist the Board of Directors in evaluating the auditor's review,  supervise
the Company's financial and accounting organization and financial reporting, and
nominate for stockholder  approval at the annual  meeting,  with the approval of
the Board of Directors,  a firm of certified public accountants whose duty it is
to audit the financial records of the Company for the fiscal year for which they
are appointed.

         THE BOARD OF DIRECTORS UNANIMOUSLY  RECOMMENDS A VOTE FOR THE CLASS III
NOMINEE FOR DIRECTOR LISTED ABOVE.


                                       -8-


<PAGE>

           STOCK OWNERSHIP OF MANAGEMENT AND CERTAIN BENEFICIAL OWNERS

         The following  table sets forth  information  as of March 5, 1997 as to
shares of Common Stock beneficially owned by (i) the Company's  directors,  (ii)
the Company's  executive  officers named in the Summary  Compensation  Table set
forth herein,  (iii) the  directors  and executive  officers of the Company as a
group and (iv) each person  known by the Company to be the  beneficial  owner of
more than five  percent of the  outstanding  shares of the  Common  Stock of the
Company.  As of March 5,  1997,  each  share of  Series A  Preferred  Stock  was
convertible at the option of the holder, unless previously redeemed,  into 21.31
shares of Common Stock. In addition,  the Series A Preferred Stock is subject to
mandatory  redemption,  as described in the following  paragraph.  Each share of
Series C  Preferred  Stock is  convertible  into that number of shares of Common
Stock  determined  by dividing the sum of $1,000 plus accrued  dividends on each
share  of  Series C  Preferred  Stock by the  conversion  price of the  Series C
Preferred  Stock.  The conversion price of the Series C Preferred Stock is equal
to 75% of the average of the closing bid prices of the Company's Common Stock on
the Nasdaq Stock Market for a specified period prior to the conversion date. The
number of shares  of Common  Stock  issuable  upon  conversion  of the  Series C
Preferred  Stock  included in the table set forth below is based upon the Nasdaq
Stock Market  closing bid price of the Company's  Common Stock on March 5, 1997,
which was $.4375.  Except as required by law or with  respect to the creation or
amendment of senior classes of preferred  stock or creation of different  series
or classes of Common  Stock,  and in certain  other  instances,  the  holders of
Series A and Series C Preferred Stock do not have voting rights until conversion
into Common Stock.  As the  conversion  rates and  anti-dilution  adjustments of
these  convertible  preferred  stocks are  influenced by the market price of the
Company's  Common Stock at any given time, the numbers of shares of Common Stock
issuable upon conversion of such instruments will be affected by fluctuations in
the market price of the Common Stock.
<TABLE>
<CAPTION>

                                                                              Amount and Nature
                                                                                 of Beneficial         Percent
Name and Address of Beneficial Owner                                             Ownership(1)          of Class
- ------------------------------------                                             ------------          --------
<S>                                                                               <C>                    <C>   
Paramount Capital Asset Management, Inc.....................................      40,915,000(2)          51.15%
    787 Seventh Avenue
    New York, New York  10019

Desai Capital Management Incorporated.......................................       3,411,853(3)           7.93%
    540 Madison Avenue
    New York, New York  10022

Institutional Venture Partners IV...........................................       2,543,783(4)           6.12%
    3000 Sand Hill Road
    Building 2, Suite 290
    Menlo Park, California 94025

SkyePharma PLC
    105 Piccadilly
    London W1V 9FN, England.................................................       2,320,561(5)           5.48%

Paul O.P. Ts'o..............................................................       887,000(6)             2.22%
Thomas H. Adams.............................................................       635,397(7)             1.58%
Robert E. Klem..............................................................       283,154(8)                 *
Lauren Brown................................................................       213,443(9)                 *
Robert Wang.................................................................       85,945(10)                 *
Zofia E. Dziewanowska.......................................................       85,233(11)                 *
Guy Van de Winckel..........................................................       60,000(11)                 *
Sharon B. Webster...........................................................        24,000(6)                 *

All directors and executive officers
    as a group (8 persons)..................................................       2,274,172(12)          5.62%

- ---------------
*        Less than one percent
</TABLE>


                                                      -9-


<PAGE>

(1)      The  number of shares  beneficially  owned is  determined  under  rules
         promulgated by the Securities and Exchange  Commission (the "SEC"), and
         the information is not necessarily  indicative of beneficial  ownership
         for any other purpose. Under such rules,  beneficial ownership includes
         any shares as to which the  individual  has sole or shared voting power
         or investment  power and also any shares which the  individual  has the
         right to  acquire  within 60 days  after  March 5,  1997,  through  the
         exercise of any stock option,  convertible  security,  warrant or other
         right.  The  inclusion  herein  of  such  shares,   however,  does  not
         constitute  an  admission  that the  named  stockholder  is a direct or
         indirect beneficial owner of such shares.  Unless otherwise  indicated,
         each  person or entity  named in the  table has sole  voting  power and
         investment  power (or shares  such power with his or her  spouse)  with
         respect to all shares of capital  stock  listed as owned by such person
         or entity.

(2)      Based on  information  as of February 24, 1996 contained in a Statement
         on  Schedule  13D  filed  with  the  SEC  by  Paramount  Capital  Asset
         Management, Inc. ("PCAM"), Dr. Lindsay A. Rosenwald, The Aries Fund and
         The Aries  Domestic  Fund,  L.P.  According  to the  Schedule  13D, Dr.
         Rosenwald and PCAM may be deemed to have shared  voting and  investment
         power  over the  26,640,500  and  14,274,500  shares of  Common  Stock,
         respectively, which may be deemed to be beneficially owned by The Aries
         Fund  and  The  Aries  Domestic  Fund,  L.P.(collectively,  the  "Aries
         Funds"). According to the Schedule 13D, The Aries Fund owns (i) 640,500
         shares of Common Stock,  (ii) $1,950,000  principal  amount of a Senior
         Secured Convertible Bridge Note (a "Convertible  Note") which,  subject
         to  antidilution  adjustments,  is initially  convertible  into 390,000
         shares of Series D Preferred  Stock (the  "Series D Preferred  Stock"),
         which,  in turn,  subject to  antidilution  adjustments,  are initially
         convertible into 13,000,000 shares of Common Stock, and (iii) five-year
         warrants to purchase  13,000,000  shares of Common Stock.  According to
         the Schedule 13D, The Aries Domestic Fund, L.P. owns (i) 274,500 shares
         of Common Stock, (ii) $1,050,000 principal amount of a Convertible Note
         which, subject to antidilution  adjustments,  is initially  convertible
         into  210,000  shares  of Series D  Preferred  Stock,  which,  in turn,
         subject to antidilution  adjustments,  are initially  convertible  into
         7,000,000  shares of Common  Stock,  and (iii)  five-year  warrants  to
         purchase  7,000,000  shares of  Common  Stock.  Pursuant  to a Note and
         Warrant Purchase Agreement dated January 28, 1997 with the Company, the
         Aries  Funds have the right to appoint a majority of the members of the
         Board of Directors of the Company; provided, however, that in the event
         the Company has not obtained Future  Financings (as defined in the Note
         and Warrant  Purchase  Agreement)  in excess of $3,500,000 on or before
         the date which is six months after the Bridge  Closing Date referred to
         therein,  then the Aries  Funds  shall  have the  contractual  right to
         appoint only two directors or observers  and, if  additional  directors
         have been appointed,  they shall be required to resign.  As of the date
         of this Proxy Statement, the Aries Funds had not exercised such right.

(3)      Desai Capital  Management  Incorporated  ("DCMI") acts as an investment
         advisor to  Equity-Linked  Investors,  L.P.  ("ELI") and  Equity-Linked
         Investors-II ("ELI-II"). Rohit M. Desai is the managing general partner
         of Rohit M.  Desai  Associates  and Rohit M. Desai  Associates-II,  the
         general partners of ELI and ELI-II, respectively. Mr. Desai is the sole
         stockholder,  Chairman  of the Board and  President  of DCMI.  Includes
         2,920,543 shares of Common Stock currently issuable upon the conversion
         of the Series A Preferred  Stock and 137,000  shares  issuable upon the
         exercise  of  warrants  beneficially  owned  by ELI  and  ELI-II.  Also
         includes  176,379  and 177,931  shares of Common  Stock held by ELI and
         ELI-II,  respectively.  Does not include  2,400  shares of Common Stock
         owned  directly  by DCMI and 600  shares  of Common  Stock  owned by an
         individually   managed  account  for  which  DCMI  provides  investment
         advisory services.

(4)      Consists of: (i) 875,618 shares of Common Stock and 1,628,693 shares of
         Common Stock issuable upon the  conversion of Series C Preferred  Stock
         beneficially  owned by  Institutional  Venture  Partners  IV;  and (ii)
         13,334 shares of Common Stock,  22,138 shares of Common Stock  issuable
         upon the  conversion  of Series C  Preferred  Stock  and  4,000  vested
         options to purchase Common Stock  beneficially  owned by  Institutional
         Venture Management IV.

(5)      Based on  information  as of June 26, 1996  contained in a Statement on
         Schedule 13D filed with the SEC by Jagotec AG ("Jagotec"), Jago Finance
         Limited,   Jago   Holding   AG  and   SkyePharma   PLC   ("SkyePharma";
         collectively,  the "Reporting Persons"). According to the Schedule 13D,
         as a result of SkyePharma's  acquisition of Jago Holding AG, SkyePharma
         has become a  beneficial  owner of the Common Stock held by Jagotec and
         Jago Finance  Limited,  and each of the Reporting  Persons has become a
         member of a "group"  within  the  meaning of  Section  13(d)(3)  of the
         Securities Exchange Act of 1934, as amended.

(6)      Includes  4,000 shares of Common Stock which Dr. Ts'o and Dr.  Webster
         may each  acquire  within 60 days after March 5, 1997  pursuant to the
         exercise of options.


                                      -10-


<PAGE>

(7)      Includes  115,000 shares of Common Stock held in several trusts for Dr.
         Adams' children, as to which Dr. Adams has shared voting and investment
         power.  Also  includes  217,075  shares  of Common  Stock  which may be
         acquired within 60 days after March 5, 1997 pursuant to the exercise of
         options.

(8)      Includes  18,750  shares of Common Stock held by a trust for Dr. Klem's
         children,  as to which Dr. Klem has shared voting and investment power.
         Includes  1,500 shares of Common Stock owned by Dr.  Klem's wife, as to
         which he disclaims beneficial ownership. Also includes 48,076 shares of
         Common  Stock which may be acquired  within 60 days after March 5, 1997
         pursuant to the exercise of options.

(9)      Includes 12,865 shares of Common Stock which may be acquired within 60
         days after March 5, 1997 pursuant to the exercise of options.

(10)     Includes 42,945 shares of Common Stock which may be acquired within 60
         days after March 5, 1997 pursuant to the exercise of options.

(11)     These  shares  may be  acquired  within  60 days  after  March 5, 1997
         pursuant to the exercise of options.

(12)     Includes 474,194 shares of Common Stock which may be acquired within 60
         days after March 5, 1997 pursuant to the exercise of options.  Includes
         133,750 shares of Common Stock held by family trusts for the benefit of
         family members of directors and officers as to which such directors and
         officers have voting and investment power.

         The Series A Preferred Stock was subject to a mandatory redemption (the
"Mandatory  Redemption")  by the Company on September 23, 1996 (the  "Redemption
Date").  Under  the  terms  of the  Mandatory  Redemption,  as set  forth in the
Company's  Certificate of Incorporation,  the Redemption Price of $50 per share,
plus accrued dividends, was to be paid, subject to certain conditions, in Common
Stock valued at an average  trading price for ten trading days before August 20,
1996 (the "Redemption Stock Value"). The Company elected to effect the Mandatory
Redemption  through the use of Common  Stock,  and then was  required to use its
best efforts to arrange with an  investment  bank  acceptable  to the holders of
Series A Preferred  Stock for a firm  commitment  underwriting  relating to such
shares.  The Company was unable to arrange for such a firm  commitment  offering
and  is now  required  to use  its  reasonable  efforts  to  arrange  for a firm
commitment  underwriting  as promptly as practicable and to redeem any remaining
outstanding  shares of Series A  Preferred  Stock upon  arranging  for such firm
commitment  underwriting.  Upon the issuance of such Common Stock (valued at the
Redemption Stock Value), the following holders of Series A Preferred Stock would
beneficially own more than five percent of the then outstanding shares of Common
Stock of the Company:

                             Number of Shares of                    Percent of
                                Common Stock                           Class
                             -------------------                    ----------
DCMI                              7,133,002(1)                        15.25%

Orefund                            3,878,361                           8.84%

Bridge & Co.                      2,553,285(2)                         6.02%

- ---------------

(1)      Includes an aggregate of 6,641,692  shares of Common Stock  issuable in
         redemption of the Series A Preferred  Stock and 137,000 shares issuable
         upon the  exercise  of warrants  beneficially  owned by ELI and ELI-II.
         Also  includes  176,379 and 177,931  shares of Common Stock held by ELI
         and ELI-II, respectively.

(2)      Includes  2,423,975  shares of Common Stock  issuable in redemption of
         the Series A Preferred  Stock and 129,310 shares of Common Stock owned
         by Bridge & Co.

                                LEGAL PROCEEDINGS

                  On  February  5,  1997,  ELI  and  ELI II  (collectively,  the
"Plaintiffs")  who, as a group, may be deemed to beneficially own more than five
percent of the outstanding  shares of the Common Stock of the Company as holders
of Series A Preferred  Stock,  filed suit (the "Suit") in the Delaware  Court of
Chancery (the "Court") against the Company,  each of the Company's directors and
the Aries  Funds.  Through the Suit,  the  Plaintiffs  are seeking to enjoin the
transactions contemplated


                                      -11-


<PAGE>

by the Note and Warrant Purchase Agreement (the  "Transactions"),  rescission of
the Transactions,  damages,  attorney fees, and such other and further relief as
the Court may deem just and proper. The Suit alleges that the Board of Directors
of the  Company  breached  fiduciary  duties by  failing to  consider  financing
alternatives to the Transactions and further alleges that the Transactions  were
not in the best interests of the  stockholders.  Additionally,  the Suit alleges
that the Aries Funds aided and abetted  such breach of  fiduciary  duty  through
their  participation  in the  Transactions.  On March 4 and 5, 1997, a trial was
held before the Court.  The Court has established a briefing  schedule and set a
hearing for post-trial arguments on April 1, 1997. The Company believes that the
lawsuit is without merit.


                COMPENSATION OF EXECUTIVE OFFICERS AND DIRECTORS

         The  following  table  sets  forth  compensation  for  services  in all
capacities to the Company,  for the fiscal years ended  December 31, 1994,  1995
and 1996 of: (i) those persons who were, respectively,  at December 31, 1996 the
Company's  Chief  Executive  Officer and the other four most highly  compensated
executive officers of the Company whose total annual salary and bonus for fiscal
year 1996 exceeded $100,000;  and (ii) one additional  individual who would have
been one of such other four most highly  compensated  executive officers if such
individual  had  served as an  executive  officer  for the  entire  fiscal  year
(collectively, the "Named Officers").

                                                      SUMMARY COMPENSATION TABLE
<TABLE>
<CAPTION>

                                                                                                           Long-Term
                                                          Annual Compensation                            Compensation
                                       ---------------------------------------------------------            Awards
                                                                                                          Securities
Name and                                                                          Other Annual            Underlying
Principal Position                    Year      Salary ($)       Bonus ($)       Compensation($)          Options(#)
- ------------------                    ----      ----------       ---------       ---------------          ----------
<S>                                   <C>       <C>               <C>             <C>                      <C>      
Thomas H. Adams, Ph.D.                1996      $285,000(5)          --                --                  27,990(5)
Chairman of the                       1995         285,000           --                --                 200,000(1)
Board and Chief                       1994         283,542           --                --                   --
Executive Officer

Zofia E. Dziewanowska,                1996      $235,000(5)          --                --                  15,735(5)
Ph.D., M.D., Senior Vice              1995         235,000           --            14,759(3)              120,000(1)
President, Global Clinical            1994       137,348(2)       10,000           14,362(3)                --
Affairs

Guy Van de Winckel                    1996        $170,000           --                --                   --
Vice President, European              1995         170,000           --                --                  60,000(1)
Operations and President              1994         170,000           --             37,000(3)               --
of Genta Pharmaceuticals
Europe, S.A.

Robert E. Klem, Ph.D.                 1996      $155,000(5)          --           2,580(4)                  8,533(5)
Vice President, Chairman              1995       161,458(8)          --           2,580(4)                 45,000(1)
of the Board of JBL                   1994         154,292           --           2,580(4)                  --

Robert Wang                           1996        $150,000           --                --                   --
Vice President                        1995       135,833(6)          --                --                  60,000(1)
Corporate Operations                  1994         130,000           --                --                   --

</TABLE>


                                                      -12-


<PAGE>
<TABLE>
<CAPTION>
                                                                                                           Long-Term
                                                          Annual Compensation                            Compensation
                                       ---------------------------------------------------------            Awards
                                                                                                          Securities
Name and                                                                          Other Annual            Underlying
Principal Position                    Year      Salary ($)       Bonus ($)       Compensation($)          Options(#)
- ------------------                    ----      ----------       ---------       ---------------          ----------
<S>                                   <C>       <C>               <C>             <C>                      <C>      
Howard Sampson(7)                     1996        $175,000           --                --                   --
Vice President and Chief              1995         132,671           --                --                    65,000
Financial Officer                     1994         123,958           --                --                   --

- ---------------
</TABLE>

(1)      These  options  (the  "New  Options")  were  granted  in  exchange  for
         unexercised  options  granted  prior to April 20, 1995 with an exercise
         price above $2.25 per share (the "Old  Options").  The New Options were
         granted  at fair  market  value at the date of grant  and have the same
         vesting schedule as the Old Options.  However, the New Options were not
         exercisable until after April 20, 1997,  regardless of the Old Option's
         vesting schedule, unless the holder is terminated involuntarily without
         cause  prior  to  April  20,  1997.  None of these  options  have  been
         exercised to date.

(2)      Dr.  Dziewanowska  joined the Company in May 1994.  Dr.  Dziewanowska's
         salary for 1994 reflects a partial year of service.

(3)      Represents payments for expenses incurred in connection with relocation
         including applicable tax gross-ups.

(4)      Represents payments for an insurance policy covering Dr. Klem.

(5)      Options were granted to Named  Officers  during the year ended December
         31, 1996 to compensate them for accepting  deferral of the payment of a
         portion of base  salary.  The  portions of  salaries  so  deferred  are
         included  in the 1996  salary  figures  in this  table,  consisting  of
         $35,625,  $19,583 and $12,917 for Dr. Adams,  Dr.  Dziewanowska and Dr.
         Klem, respectively.

(6)      Effective  September  1, 1995 Dr.  Wang  received a salary  increase of
         $20,000  and stock  options  exercisable  for  20,000  shares of Common
         Stock.  The  additional  40,000  options  are New  Options  granted  in
         exchange for Old Options.

(7)      In October,  1996, Mr. Sampson  entered into an executive  compensation
         agreement with the Company which requires (i) the continued  payment of
         Mr. Sampson's salary at his then current rate of $175,000 until October
         18, 1997, the first anniversary of the date of Mr. Sampson's  voluntary
         resignation  from the Company;  (ii) eligibility for coverage under the
         Company's  health  insurance plan; and (iii) the grant of 75,000 shares
         of the Company Common Stock at no cost to Mr.  Sampson.  As of the date
         of this  Proxy  Statement,  such  shares  have not been  issued  to Mr.
         Sampson.  In 1996,  Mr.  Sampson  received an  aggregate  of $37,522 in
         severance payments under the agreement.

(8)      Represents 25 bi-monthly pay periods during 1995 that resulted from Dr.
         Klem's having been transferred  from the Company's  payroll calendar to
         JBL's payroll calendar in September of 1995.

COMPENSATION OF DIRECTORS

         Directors  of the  Company  receive  no  fees  for  their  services  as
directors or committee  members.  Non-employee  directors are  reimbursed by the
Company for their  out-of-pocket  expenses incurred in attending meetings of the
Board of Directors and its committees.  In addition,  non-employee directors are
eligible to receive  automatic grants of nonstatutory  stock options pursuant to
the 1991 Stock Plan.

         During 1996, Dr. Ts'o, a non-employee director,  received $38,333 under
a consulting  agreement  between Dr. Ts'o and the Company.  The agreement may be
terminated by either party upon giving written notice to that effect.


                                      -13-


<PAGE>

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         For the Company's fiscal year ended December 31, 1996, Thomas H. Adams,
James C. Blair and David F. Hale were the members of the Company's  Compensation
Committee.  Mr. Blair  resigned  from the Board of Directors on October 8, 1996.
Mr. Hale resigned from the Board of Directors on January 28, 1997.  Dr. Adams is
Chairman of the Board of Directors and Chief  Executive  Officer of the Company.
None of the executive  officers of the Company had any "interlock"  relationship
to report during the Company's fiscal year ended December 31, 1996.

         The Company's  Relationship with Jagotec. In December 1992, the Company
and Jagotec formed Genta Jago  Technologies  B.V ("Genta  Jago"),  a 50/50 joint
venture to develop and commercialize  therapeutic products on a worldwide basis.
In 1996,  SkyePharma acquired Jagotec. Dr. Adams is a managing director of Genta
Jago.

         Among other  things,  the Company is required to provide loans to Genta
Jago pursuant to a working capital  agreement which expires in October 1998. The
loans are advanced up to a mutually agreed upon maximum commitment amount, which
amount is  established  by the parties on a periodic  basis.  As of December 31,
1996,  the  Company  had  advanced   working  capital  loans  of   approximately
$15,300,000 to Genta Jago, net of principal repayments and credits, which amount
fully satisfied the loan commitment  established by the parties through December
31, 1996.  Such loans bear  interest and are payable in full in October 1998, or
earlier in the event  certain  revenues  are  received  by Genta Jago from third
parties.  There can be no  assurance,  however,  that Genta Jago will obtain the
necessary financial resources to repay such loans to the Company.

         Under the terms of the joint venture,  Genta Jago has  contracted  with
the  Company to conduct  research  and  development  and provide  certain  other
services.  Revenues associated with providing such services, totaling $1,500,000
in 1996, were recorded by the Company as a reduction of the related research and
development and general and  administrative  expenses.  Terms of the arrangement
also grant the Company an option to purchase SkyePharma's interest in Genta Jago
exercisable from December 1998 through 2000.

         Genta Jago's  Collaboration  with Gensia.  In January 1993,  Genta Jago
entered into a  collaboration  agreement  with Gensia,  Inc.  ("Gensia") for the
development   and   commercialization   of   certain   oral   controlled-release
pharmaceutical  products for  treatment of  cardiovascular  disease (the "Gensia
Agreement").  Under the agreement, Gensia was to provide funding for formulation
and  preclinical  development  to be  conducted  by  Genta  Jago  and  was to be
responsible  for clinical  development,  regulatory  submissions  and marketing.
Gensia in turn in 1994 entered into a  collaboration  with  Boehringer  Mannheim
Pharmaceuticals  Corporation  ("Boehringer")  to develop  and  co-promote  Genta
Jago's potential  nifedipine  product.  Gensia  transferred its rights under the
collaboration   agreement   with  Genta  Jago  to   Brightstone   Pharma,   Inc.
("Brightstone"),  SkyePharma's  U.S.  subsidiary,  in October,  1996. In January
1993,  Genta Jago  entered into a  collaboration  agreement  with  Gensia,  Inc.
("Gensia")  for  the   development  and   commercialization   of  a  potentially
bioequivalent  nifedipine  product,  an oral  controlled-release  pharmaceutical
product for treatment of cardiovascular disease. Under the agreement, Gensia was
to provide funding for formulation  and  preclinical  development.  Terms of the
agreement provided Gensia exclusive rights to market and distribute the products
in North America,  Europe and certain other countries.  Genta Jago received $2.2
million,  $1.9 million and $4.9 million of research and  development  funding in
1996,  1995 and 1994,  respectively,  pursuant to the  agreement.  Collaborative
revenues of $2.8 million,  $3 million and $4.2 million were recognized under the
agreement during the years ended December 31, 1996, 1995 and 1994, respectively.

         Dr. Adams is a member of Gensia's  Scientific Advisory Board. Mr. Hale,
a former outside director, is Chairman of the Board of Directors,  President and
Chief Executive Officer of Gensia.

PENSION AND LONG-TERM INCENTIVE PLANS

         The Company has no pension or long-term incentive plans.


                                      -14-


<PAGE>

                                  STOCK OPTIONS

         The  following  tables  summarize the option grants to and exercises by
the Named  Officers  and the value of these  options held by such persons at the
end of fiscal 1996. The Company does not grant Stock Appreciation Rights. Grants
of options to  purchase a total of 128,323  shares  were made in 1996  solely to
compensate employees for accepting deferral of a portion of their salaries.  The
Company  granted  options to purchase a total of 128,323  shares to employees in
fiscal 1996.

<TABLE>
<CAPTION>

                                              OPTION GRANTS IN FISCAL YEAR 1996
                                                                                              POTENTIAL REALIZABLE VALUE
                                                                                              AT ASSUMED ANNUAL RATES
                                                                                              STOCK PRICE APPRECIATION
                                                        INDIVIDUAL GRANTS                         FOR OPTION TERM(1)
                                          -------------------------------------------------    ------------------------ 
                                           NUMBER OF     % OF
                                          SECURITIES TOTAL OPTIONS   EXERCISE
                                          UNDERLYING  GRANTED TO      OR BASE
                                            OPTIONS  EMPLOYEES IN      PRICE       EXPIRATION
NAME                                      GRANTED (#) FISCAL YEAR     ($/SH)          DATE         5%($)        10%($)
- ----                                      ----------- -----------     ------        --------     ---------    --------
<S>                                         <C>           <C>      <C>    <C>          <C>        <C>           <C>   
Thomas H. Adams, Ph.D.................      27,990        22%      17,812 2.06         2006       23,156        58,601
                                                                   10,178 1.75         2006       11,196        28,396

Zofia E. Dziewanowska, Ph.D., M.D.....      15,735        12%       7,343 2.06         2006        9,546        24,158
                                                                    8,392 1.75         2006        9,231        23,414

Guy Van De Winckel....................        --          --             --              --        --           --

Robert E. Klem, Ph.D..................       8,533         6%       4,843 2.06         2006        6,296        15,933
                                                                    3,690 1.75         2006        4,059        10,295

Robert Wang...........................        --          --             --              --        --           --

Howard Sampson........................        --          --             --              --        --           --
</TABLE>

- ---------------

(1)      Assumes that the stock prices on the relevant  grant dates ($2.0625 and
         $1.75 on February 8, 1996 and June 18,  1996,  respectively)  will have
         grown, as indicated,  at: (a) 5% per annum over the term of the option,
         to $3.3596  and  $2.8506,  respectively;  or (b) 10% per annum over the
         term of the option,  to $5.3496 and $4.5390,  respectively.  The 5% and
         10%  assumed  rates of  appreciation  are  calculated  pursuant  to the
         regulations  promulgated  by the SEC and do not represent the Company's
         estimate or projection of the future Common Stock price.


                                      -15-


<PAGE>

                    OPTION EXERCISES IN LAST FISCAL YEAR AND
                          FISCAL YEAR END OPTION VALUES
<TABLE>
<CAPTION>

                                                                  Number of
                                                                 Securities                 Value of
                                                                 Underlying                Unexercised
                                                                 Unexercised              In-the-Money
                                                                 Options at                Options at
                                                             Fiscal Year End(#)       Fiscal Year End($)(1)
                                                             ------------------      -----------------------
                        Shares Acquired       Value
Name                    On Exercise (#)   Realized ($)     Exercisable Unexercisable  Exercisable Unexercisable
- ----                    ---------------   ------------     ----------- -------------  ----------- -------------
<S>                      <C>               <C>              <C>             <C>       <C>            <C>
Thomas H. Adams, Ph.D.   --                  --             217,075         10,915     --            --

Zofia E. Dziewanowska,
   Ph.D., M.D.           --                  --              95,908         39,827     --            --

Guy Van de Winckel       --                  --              60,000          --        --            --

Robert E. Klem, Ph.D.    --                  --              48,076          5,457     --            --

Howard Sampson           --                  --              82,624         32,376     --            --

Robert Wang              --                  --              42,945         17,055     --            --

- ---------------------
</TABLE>

(1)      Calculated  on the  basis of the fair  market  value of the  underlying
         securities  as of  December  31, 1996  ($.4375  per  share),  minus the
         exercise price.

                  BOARD REPORT TO STOCKHOLDERS ON COMPENSATION

OVERVIEW

         Although the Board of  Directors  appointed a  Compensation  Committee,
each of its independent  members resigned from the Board of Directors before the
Committee had met to make any  determinations or recommendations to the Board of
Directors as to the  compensation of the Company's  Chief Executive  Officer and
other  executive  officers.  Accordingly,  this Report is being made by the full
Board of Directors.

         The Company seeks to achieve three objectives which serve as guidelines
in making compensation decisions:

         o        Providing a total  compensation  package which is  competitive
                  and, therefore,  enables the Company to attract and retain, on
                  a long-term basis, high-caliber executive personnel;

         o        Integrating   compensation   programs   with   the   Company's
                  short-term   and   long-term   strategic   plan  and  business
                  objectives; and

         o        Encouraging achievement of business objectives and enhancement
                  of  stockholder  value  by  providing   executive   management
                  long-term incentive through equity ownership.

     In making its compensation determinations, the Board of Directors and prior
years' Compensation  Committees have relied, in part, on independent surveys and
analyses of  management  compensation  of  companies  in the  biotechnology  and
pharmaceutical  industries  (including  companies  in the Nasdaq  Pharmaceutical
Stock Index used in the  Company's  Stock Price  Performance  Graph set forth in
this Proxy Statement) and recommendations of management.  The Board of Directors
believes it has established executive  compensation levels which are competitive
with companies in the  biotechnology and  pharmaceutical  industries when taking
into  account   relative   company  size,   stage  of  development,   individual
responsibilities  and experience,  individual and overall corporate  performance
and geographic location.


                                      -16-


<PAGE>

COMPONENTS OF EXECUTIVE COMPENSATION

     The  Company's  potential  therapeutic  products  are in various  stages of
research  and  development,  and no  revenues  have as yet been  generated  from
therapeutic  product  sales.  As a result,  the use of  traditional  performance
standards,  such as corporate profitability,  are not believed to be appropriate
in  the  evaluation  of  the  performance  of  the  Company  or  its  individual
executives.  The compensation of the Company's  executive  officers is based, in
substantial  part,  on the  achievement  of  individual  and  overall  corporate
objectives. Such objectives are established and modified as necessary to reflect
changes  in  market  conditions,  and  other  factors.  Individual  and  overall
corporate   performance  is  measured  by  reviewing   whether  these  corporate
objectives have been achieved.

     The  Company's   compensation  package  for  executive  officers  generally
consists of annual cash  compensation and long-term  compensation in the form of
stock  options.  In light of the Company's  stage of  development,  considerable
emphasis is placed on equity-based compensation in an effort to preserve cash to
finance the Company's research and development efforts.

ANNUAL CASH COMPENSATION

     Compensation levels for the Company's executive officers are determined, in
part, through comparisons with companies of a similar size, stage of development
and level of complexity in the biotechnology and pharmaceutical  industries, and
other companies with which the Company competes for personnel.  In addition, the
compensation  level for each  executive  officer  reflects an  evaluation of the
responsibilities  required for each respective position,  individual  experience
levels, and individual  performance and contributions  toward achievement of the
Company's  business  objectives.  The  compensation  levels  for  the  Company's
executive  officers,  including the Chief Executive Officer,  are designed to be
competitive  within a range that the  Compensation  Committee  determines  to be
reasonable  in light of the  aforementioned  factors.  Compensation  levels  are
generally  set at the  midrange of the  comparable  companies in order to remain
competitive  and  attract key  personnel.  The salary  levels of each  executive
officer  are  reviewed  on an annual  basis and  adjustments  are made as deemed
necessary.

STOCK OPTIONS

      The Board of  Directors  of the Company  believes  that by  providing  all
full-time  employees,  including  executive officers who have responsibility for
the  management  and growth of the  Company,  with an  opportunity  to obtain an
equity  interest  in  the  Company,  the  best  interests  of  stockholders  and
executives  will be  closely  aligned.  Accordingly,  all  full-time  employees,
including executive  officers,  are eligible to receive stock option grants from
time to time,  giving them the right to purchase shares of the Company's  Common
Stock at a specified price.

COMPENSATION OF EXECUTIVE OFFICERS

     In making compensation decisions for 1996, the Board of Directors took into
account the Company's limited cash resources,  its weakened financial condition,
the general  financial  performance of the Company and its  subsidiaries  during
1996  and  the  importance  of  retaining  the  Company's  cash to  finance  its
development  programs.  The Board of Directors also considered the importance to
the Company of retaining  highly  qualified key personnel due to the complex and
technologically  sophisticated  nature of the  Company's  business.  In light of
these  factors,  it was decided to increase the base  salaries of Drs.  Klem and
Brown,  based on JBL's  performance,  but not to increase the base salary of any
other executive  (other than Mr.  Sampson) beyond 1995 levels,  not to award any
bonuses and to request that certain  executives,  including Drs. Klem and Brown,
defer a portion of their  base  salary.  The Board of  Directors  granted  stock
options in 1996 only to  compensate  the  executives  for such  deferral of base
salary. The above disclosure is not applicable to Mr. Sampson,  the former Chief
Financial  Officer of the Company,  who informed the Company in September,  1996
that he would not continue to perform  essential  duties for the Company  unless
the Company entered an employment contract,  effective as of January 1, 1996, on
terms  acceptable to him. See footnote 7 to the Summary  Compensation  Table set
forth under the caption  "Compensation of Executive  Officers and Directors." In
light of the serious economic issues then faced by the Company, the Company felt
it had no alternative but to enter into such employment contract.


                                      -17-


<PAGE>

     This Compensation  Report shall not be deemed  incorporated by reference by
any general  statement  incorporating by reference this Proxy Statement into any
filing under the  Securities  Act of 1933, as amended,  or under the  Securities
Exchange Act of 1934, as amended,  except to the extent the Company specifically
incorporates  this report by reference,  and shall not otherwise be deemed filed
under such Acts.

                                                   Thomas H. Adams, Ph.D.

                                                   Robert E. Klem, Ph.D.

                                                   Paul O.P. Ts'o, Ph.D.

                                                   Sharon B. Webster, Ph.D.


                                      -18-


<PAGE>

                          STOCK PRICE PERFORMANCE GRAPH

     The following  graph  illustrates a comparison of the five-year  cumulative
total  stockholder  return (change in stock price plus reinvested  dividends) of
the  Company's  Common  Stock  with the CRSP Total  Return  Index for The Nasdaq
National Market (U.S. and Foreign) (the "Nasdaq  Composite  Index") and the CRSP
Total Return Index for Nasdaq Pharmaceutical Stocks (the "Nasdaq  Pharmaceutical
Index").1  The  comparisons  in the  graph are  required  by the SEC and are not
intended to forecast or be  indicative  of possible  future  performance  of the
Company's Common Stock.

                               [GRAPHIC OMITTED]


<TABLE>
<CAPTION>


                                    December 31,  December 31,    December 31,   December 31,   December 31,   December 31,
                                        1991         1992            1993            1994           1995           1996
                                        ----         ----            ----            ----           ----           ----
<S>                                      <C>         <C>             <C>           <C>            <C>            <C>  
Genta Incorporated..................     $100        $92.31          $75.69        $52.56         $25.64         $4.99
Nasdaq Composite....................      100        116.03          134.32        130.28         182.96        224.06
Nasdaq Pharmaceutical...............      100         83.22           74.17         55.83         102.05        102.44

</TABLE>

         Assumes a $100 investment on December 31, 1991 in each of the Company's
Common Stock,  the securities  comprising the Nasdaq  Composite  Index,  and the
securities comprising the Nasdaq Pharmaceutical Index.

- --------
1 The Nasdaq  Pharmaceutical  Index  includes all companies on Nasdaq within SIC
code  283.  A  copy  of  the  list  of  companies   which  comprise  the  Nasdaq
Pharmaceutical   Index  may  be  obtained  upon  request  by  contacting   Genta
Incorporated,  Investor  Relations,  3550  General  Atomics  Court,  San  Diego,
California 92121 (619) 455-2700.


                                      -19-


<PAGE>

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         In February  1989,  the Company  entered into a license  agreement with
Drs. Paul Ts'o and Paul Miller (the "Ts'o/Miller  Agreement")  pursuant to which
Drs.  Ts'o and Miller  granted an  exclusive  license to the  Company to certain
issued patents,  patent applications and related technology regarding the use of
nucleic   aids   and   oligonucleotides,    including   methylphosphonates,   as
pharmaceutical  agents. Dr. Ts'o is a Director of the Company and a Professor of
Biophysics,  Department of  Biochemistry  at Johns Hopkins,  and Dr. Miller is a
Professor of  Biochemistry,  at the School of Public  Health and Hygiene,  Johns
Hopkins.  In May 1990, the Company  entered into a license  agreement with Johns
Hopkins (the "Johns Hopkins  Agreement," and such  agreement,  together with the
Ts'o/Miller  Agreement,  being  referred  to herein as the  "Ts'o/Miller/Hopkins
Agreements")  pursuant to which Johns  Hopkins  granted the Company an exclusive
license to its rights in certain issued patents, patent applications and related
technology  developed as a result of research conducted at Johns Hopkins by Drs.
Ts'o and Miller and related to the use of nucleic acids and obligonucleotides as
pharmaceutical  agents.  In  addition,  Johns  Hopkins  has  granted the Company
certain rights of first  negotiation to inventions  made by Drs. Ts'o and Miller
in their  laboratories  in the area of  oligonucleotides  and inventions made by
investigators  at Johns Hopkins in the course of research funded by the Company,
which  inventions  are  not  otherwise   included  in  the   Ts'o/Miller/Hopkins
Agreements. The Company has agreed to pay Dr. Ts'o, Dr. Miller and Johns Hopkins
royalties  on net sales of  products  covered by the issued  patents  and patent
applications, but not the related technology,  licensed to the Company under the
Ts'o/Miller/Hopkins  Agreement.  The  Company  has also  agreed  to pay  certain
minimum  royalties prior to  commencement of commercial  sales of such products,
which  royalties may be credited  under  certain  conditions  against  royalties
payable on subsequent sales. Subject to certain rights of early termination, the
Ts'o/Miller/Hopkins   Agreements   remain  in   effect   for  the  life  of  the
last-to-expire   patent  licensed  under  the  respective  agreements  or  until
abandonment of the last-pending patent application licensed under the respective
agreements.

         As of December 31, 1996 the Company  owed Johns  Hopkins  $627,271,  of
which  $200,000  consists of royalty  payments for 1995 and 1996.  The remainder
consists  of  the  Company's  outstanding  obligation  to  provide  funds  for a
post-doctoral program at Johns Hopkins. In February, 1997 the Company paid Johns
Hopkins $100,000 towards the Company's  post-doctoral  support obligations.  The
Company is in the process of  negotiations  with Johns Hopkins as to the payment
of a portion of the balance due in securities  rather than cash. On February 14,
1997,  the Company  received  notice from Johns  Hopkins that the Company was in
material  breach of the Johns Hopkins  Agreement.  The Johns  Hopkins  Agreement
provides  that,  if a material  payment  default is not cured  within 90 days of
receipt of the notice of the  breach,  Johns  Hopkins  may  terminate  the Johns
Hopkins  Agreement.  Such a termination  could have a material adverse effect on
the Company.

         In July 1991, a trust as to which Mr. Hale, a former Board member,  has
shared  voting  and  investment  power  acquired  25,000  shares of  convertible
preferred  stock of the  Company  (which  converted  into  12,500  shares of the
Company's Common Stock upon the closing of the Company's initial public offering
in December 1991) at a purchase price of $50,000, including a promissory note of
$49,975,  secured by the shares of stock.  The note, which bears interest at the
rate of 8% per annum (compounded annually), had an outstanding balance including
accrued interest of approximately $76,380 at December 31, 1996, and, as amended,
was  forgiven by the Board of  Directors  on December 30, 1996 in return for the
cancellation  of the 12,500 shares of Common Stock which secured the note. As of
March 5, 1997, this cancellation had not yet been effected.

         In February  1991,  in  connection  with the  acquisition  of JBL,  the
Company  assumed  certain leases  between JBL and Granada  Associates and Sueldo
Associates,  both of which are  affiliates of Drs.  Brown and Klem. Dr. Brown is
currently  Vice  President of the Company and President of JBL. Dr. Klem is Vice
President of the Company and Chairman of the Board of JBL. The current aggregate
monthly payment under such leases is approximately $32,000.

         See "Compensation Committee Interlocks and Insider Participation" for a
description  of certain  arrangements  between  Genta Jago and  Gensia.  Genta's
Chairman and Chief Executive Officer is a member of Gensia's Scientific Advisory
Board.


                                      -20-


<PAGE>

                                 PROPOSAL THREE
               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS

         The Board of  Directors  has  selected the firm of Ernst & Young LLP as
the Company's  independent auditors for the fiscal year ended December 31, 1997,
subject to ratification by the stockholders at the Annual Meeting. Ernst & Young
LLP has audited the Company's financial statements since the Company's inception
in  February  1988.  Representatives  of Ernst & Young  LLP are  expected  to be
present  at the  Annual  Meeting.  They  will  have  an  opportunity  to  make a
statement,  if they desire to do so, and are expected to be available to respond
to appropriate questions.

         THE  BOARD OF  DIRECTORS  UNANIMOUSLY  RECOMMENDS  A VOTE FOR  PROPOSAL
THREE.


                                      -21-


<PAGE>

                              STOCKHOLDER PROPOSALS

         Proposals of  stockholders  intended to be presented at the 1998 annual
meeting of  stockholders  of the Company  must be received by the Company at the
offices of the Company,  at 3550 General  Atomics Court,  San Diego,  California
92121 no later  than  November  14,  1997 in order to be  included  in the proxy
statement and form of proxy relating to such annual meeting.

             SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

         Under Section 16(a) of the Securities Exchange Act of 1934, as amended,
the Company's  directors,  executive  officers and any persons holding more than
10% of the Company's Common Stock are required to report their initial ownership
of the Company's  Common Stock and any  subsequent  changes in that ownership to
the SEC.  Specific  due dates for these  reports have been  established  and the
Company is required to identify in this proxy statement those persons who failed
to timely file these  reports.  All of the filing  requirements  were  satisfied
except  for an Annual  Statement  on Form 5 for  Robert  Wang.  In  making  this
disclosure,  the Company  has relied  solely on written  representations  of its
directors and executive  officers and copies of the reports that have been filed
with the SEC.

                                  OTHER MATTERS

         The  Board  of  Directors  knows  of no  other  business  that  will be
presented  at the Annual  Meeting.  If any other  business is  properly  brought
before the Annual Meeting, it is intended that proxies in the enclosed form will
be voted in accordance with the judgment of the persons voting the proxies.

         Whether you intend to be present at the Annual  Meeting or not, we urge
you to return your signed proxy promptly.

                                          By order of the Board of Directors,

                                          /s/ Thomas H. Adams
                                          -------------------
                                          Thomas H. Adams, Ph.D.
                                          Chairman of the Board and
                                          Chief Executive Officer

Dated:  March 14, 1997


<PAGE>

                                                                      EXHIBIT A
                            CERTIFICATE OF AMENDMENT
                                       OF
                      RESTATED CERTIFICATE OF INCORPORATION
                                       OF
                               GENTA INCORPORATED

         GENTA INCORPORATED,  a corporation  organized and existing under and by
virtue of the General Corporation Law of the State of Delaware,

         DOES HEREBY CERTIFY:

         FIRST:   That  at  a  meeting  of  the  Board  of  Directors  of  Genta
Incorporated,  resolutions were duly adopted setting forth a proposed  amendment
of the Restated  Certificate of Incorporation of the corporation,  and declaring
that such amendment is advisable and that such amendment  should be submitted to
the stockholders of the corporation for approval.  The resolution  setting forth
the proposed amendment is as follows:

                  RESOLVED,  that the first paragraph of Section A of Article IV
of the Restated Certificate of Incorporation, as amended, of this corporation be
amended to substantially read as follows:

                  "A.  Classes  of  Stock.  The  total  number  of shares of all
         classes of capital stock which the corporation  shall have authority to
         issue is  seventy-five  million  (75,000,000)  of which seventy million
         (70,000,000)  shares of the par value of One Tenth of One Cent  ($.001)
         each  shall be Common  Stock  (the  "Common  Stock")  and Five  Million
         (5,000,000)  shares of the par  value of One Tenth of One Cent  ($.001)
         each shall be Preferred Stock (the "Preferred Stock"). At the time this
         amendment becomes  effective,  each ten shares of the Common Stock, par
         value  of  One  Tenth  of  One  Cent  ($.001)  per  share,  issued  and
         outstanding  at such  time  shall  be,  and  hereby  are,  reduced  and
         converted into one fully paid and nonassessable  share of Common Stock,
         par  value  of  One  Tenth  of  One  Cent  ($.001)  per  share,  of the
         corporation as herein authorized. Each outstanding stock certificate of
         this  corporation  which  immediately  prior to the time this amendment
         becomes  effective  represented one or more shares of Common Stock, par
         value of One Tenth of One Cent  ($.001)  per  share,  shall  thereafter
         represent the number of whole shares of Common Stock,  par value of One
         Tenth of One Cent ($.001) per share,  determined by dividing the number
         of shares represented by such certificate immediately prior to the time
         this amendment  becomes effective by ten and rounding such number up to
         the next whole  integer.  The amount of capital  represented by the new
         shares in the  aggregate  at the time  this  Certificate  of  Amendment
         becomes effective shall be adjusted by the transfer of One Tenth of One
         Cent  ($.001)  from the  capital  account  of the  Common  Stock to the
         additional  paid in capital  account for each new share issued  (except
         for new shares issued as the result of rounding up fractional shares in
         which case no capital  adjustment  shall be made),  such transfer to be
         made at such time.  The  corporation  shall not be required to issue or
         deliver  any  fractional  shares  of  Common  Stock.   There  shall  be
         designated  as capital in respect of such new shares an amount equal to
         the aggregate par value of such shares.  Upon  surrender by a holder of
         Common Stock of a certificate  or  certificates  for Common Stock,  par
         value of One Tenth of One Cent ($.001), duly endorsed, at the office of
         the  corporation,   the  corporation  shall,  as  soon  as  practicable
         thereafter,  issue and  deliver at such office to such holder of Common
         Stock,  or to the nominee or nominees of such holder,  a certificate or
         certificates for the number of shares of Common Stock, par value of One
         Tenth of One Cent  ($.001)  per share,  to which such  holder  shall be
         entitled as aforesaid."

         SECOND: Thereafter,  pursuant to resolutions of the corporation's Board
of Directors, the amendment was submitted to the stockholders of the corporation
for approval at a Meeting of Stockholders,  and such meeting was called and held
upon notice in accordance with Section 222 of the General Corporation Law of the
State of Delaware.  The  necessary  number of shares as required by statute were
voted in favor of the amendment.

         THIRD:  The said  amendment  was duly  adopted in  accordance  with the
provisions  of  Section  242 of the  General  Corporation  Law of the  State  of
Delaware.


                                       -1-


<PAGE>

         IN WITNESS WHEREOF,  said corporation has caused this certificate to be
signed by Thomas H. Adams,  its Chairman of the Board,  and by Robert Wang,  its
Vice President, as of this ____ day of ________, 1997.

                                             GENTA INCORPORATED


                                             By 
                                             ----------------------
                                               Thomas H. Adams
                                             Chairman of the Board

Attest:



- ------------------------------
            Robert Wang
           Vice President


                                       -2-


<PAGE>

                               GENTA INCORPORATED
               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                      FOR ANNUAL MEETING ON APRIL 4, 1997.

         The  undersigned  stockholder  of Genta  Incorporated  (the  "Company")
acknowledges  receipt of Notice of Annual Meeting of Stockholders  and the Proxy
Statement  each  dated  March 14,  1997 and the  undersigned  revokes  all prior
proxies and appoints  Thomas H. Adams,  Robert Wang, or either of them,  proxies
for the  undersigned to vote all shares of Common Stock of the Company which the
undersigned  would be entitled to vote at the Meeting of Stockholders to be held
at the Hyatt Regency, 3777 La Jolla Village Drive, La Jolla, California at 11:00
a.m. on April 4, 1997 and any postponement or adjournment thereof, and instructs
said proxies to vote as follows:

         1.       APPROVAL FOR A ONE FOR TEN REVERSE SPLIT OF THE COMPANY'S
                  OUTSTANDING COMMON STOCK AND DECREASE IN THE NUMBER OF
                  AUTHORIZED SHARES OF COMMON STOCK:

         [  ]      FOR            [  ]    AGAINST         [  ]  ABSTAIN


         2.       ELECTION OF DIRECTORS:

         [  ]     FOR the Class III nominee listed below



         [  ]     WITHHOLD AUTHORITY  to vote for the Class  III nominee listed
                  below


         Robert E. Klem, Ph.D.

         3.       TO  RATIFY  THE  APPOINTMENT  OF  ERNST  &  YOUNG  LLP  AS THE
                  INDEPENDENT AUDITORS OF THE COMPANY:

         [  ]     FOR            [  ]    AGAINST         [  ]  ABSTAIN

         4.       In their  discretion,  the proxies are authorized to vote upon
                  such other business as may properly come before the meeting.


<PAGE>

THIS PROXY  WILL BE VOTED IN  ACCORDANCE  WITH THE  SPECIFICATIONS  MADE.  IF NO
SPECIFICATIONS  ARE MADE,  THIS PROXY WILL BE VOTED FOR  APPROVAL OF THE REVERSE
STOCK SPLIT AND REDUCTION IN THE NUMBER OF AUTHORIZED  SHARES OF COMPANY  COMMON
STOCK,  FOR THE  ELECTION  OF THE CLASS III NOMINEE  FOR  DIRECTOR,  AND FOR THE
RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP AS INDEPENDENT AUDITORS.

                                        GENTA INCORPORATED
                                        BOARD OF DIRECTORS PROXY
                                        Meeting of Stockholders April 4, 1997


                                        Dated:_______________________________


                                        ---------------------------------------
                                              (Signature of Stockholder)


                                        ---------------------------------------
                                              (Signature of Stockholder)

         Please sign exactly as your name or names appear  hereon.  When signing
as attorney,  executor,  administrator,  trustee or  guardian,  please give full
title as such. If shares are held jointly, each holder must sign.

         PLEASE MARK,  SIGN,  DATE AND MAIL THIS PROXY CARD PROMPTLY,  USING THE
ENCLOSED ENVELOPE.


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