GENTA INCORPORATED /DE/
SC 13D/A, 1997-12-31
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 4)*

                               Genta Incorporated
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                     Common Stock, par value $.001 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                  372 45 M 20 7
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                                 with a copy to:
David R. Walner, Esq.                                    Monica C. Lord, Esq.
Paramount Capital Asset                                  Kramer, Levin,
   Management, Inc.                                        Naftalis & Frankel
787 Seventh Avenue                                       919 Third Avenue
New York, NY 10019                                       New York, NY  10022
(212) 554-4372                                           (212) 715-9100

   (Name, Address and Telephone Number of Person Authorized to Receive Notices
                              and Communications)

                                December 29, 1997
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following:     [_]

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule 13d- 1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


                               Page 1 of 11 Pages

<PAGE>

- --------------------------                       -------------------------------
CUSIP No. 372 45 M 20 7              13D                     Page 2 of 11 Pages
- --------------------------                       -------------------------------

- -------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Paramount Capital Asset Management, Inc.
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [_]
- -------------------------------------------------------------------------------
    3      SEC USE ONLY

- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

           OO (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          None
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 14,469,496**
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   None 
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          14,469,496**
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           14,469,496**
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           64.7% (37.7% of the outstanding voting power)***
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           CO
- -------------------------------------------------------------------------------
** Does not include shares of Common Stock (the "Note Interest  Common  Shares")
issuable upon  conversion of the Series D Convertible  Preferred  Stock issuable
upon  conversion of the interest on the 12% Senior  Secured  Convertible  Bridge
Notes. As of December 31, 1997, Paramount Capital Asset Management,  Inc. may be
deemed  beneficially  to  own  (within  the  meaning of  Rule 13d-3  under  the
Securities  Exchange  Act of 1934, as amended)  573,777 Note  Interest  Common
Shares. 
*** The  outstanding  shares  of  Series D  Preferred  Stock of the  Issuer  are
entitled  to vote  together  with the  holders  of Common  Stock on all  matters
submitted  to a vote of  stockholders  of the Issuer.  As of December  29, 1997,
Paramount  Capital  Asset  Management, Inc.  may be deemed  beneficially  to own
(within the meaning of Rule 13d-3 under the Securities  Exchange Act of 1934, as
amended)  37.7% of the aggregate  voting power of the Common Stock and Series D
Preferred Stock outstanding.


<PAGE>

- --------------------------                       -------------------------------
CUSIP No. 372 45 M 20 7              13D                     Page 3 of 11 Pages
- --------------------------                       -------------------------------

- -------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Aries Domestic Fund, L.P.
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [_]
- -------------------------------------------------------------------------------
    3      SEC USE ONLY

- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

           OO (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          None
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 5,053,220**
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   None 
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          5,053,220**
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           5,053,220**
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           22.6% (13.2% of the outstanding voting power)***
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           PN
- -------------------------------------------------------------------------------
** Does not include any Note Interest Common Shares.  As of December 31, 1997, 
the Aries Domestic Fund,  L.P. may be deemed  beneficially to own (within the
meaning of Rule 13d-3 under the  Securities  Exchange  Act of 1934,  as amended)
200,822 Note Interest  Common  Shares.  
*** The  outstanding  shares  of  Series D  Preferred  Stock of the  Issuer  are
entitled  to vote  together  with the  holders  of Common  Stock on all  matters
submitted to a vote of stockholders of the Issuer.  As of December 29, 1997, the
Aries Domestic Fund, L.P. may be deemed  beneficially to own (within the meaning
of Rule 13d-3 under the Securities  Exchange Act of 1934, as amended)  13.2% of
the  aggregate  voting  power of the Common  Stock and Series D Preferred  Stock
outstanding.


<PAGE>

- --------------------------                       -------------------------------
CUSIP No. 372 45 M 20 7              13D                     Page 4 of 11 Pages
- --------------------------                       -------------------------------

- -------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           The Aries Trust
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [_]

- -------------------------------------------------------------------------------
    3      SEC USE ONLY

- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

           OO (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Cayman Islands

- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          None
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 9,416,276**
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   None 
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          9,416,276**
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           9,416,276**
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           42.1% (24.5% of the outstanding voting power)***
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           OO (see Item 2)
- -------------------------------------------------------------------------------
** Does not include any Note Interest Common Shares.  As of December 31, 1997, 
The Aries Trust may be deemed beneficially to own (within the meaning of Rule
13d-3 under the Securities Exchange Act of 1934, as amended)  372,955 Note
Interest Common Shares.  
*** The  outstanding  shares  of  Series D  Preferred  Stock of the  Issuer  are
entitled  to vote  together  with the  holders  of Common  Stock on all  matters
submitted to a vote of stockholders of the Issuer.  As of December 29, 1997, The
Aries Trust may be deemed  beneficially to own (within the meaning of Rule 13d-3
under the Securities  Exchange Act of 1934, as amended)  24.5% of the aggregate
voting power of the Common Stock and Series D Preferred Stock outstanding.


<PAGE>

- --------------------------                       -------------------------------
CUSIP No. 372 45 M 20 7              13D                     Page 5 of 11 Pages
- --------------------------                       -------------------------------

- -------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Lindsay A Rosenwald, M.D.
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [_]
- -------------------------------------------------------------------------------
    3      SEC USE ONLY

- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

           OO (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          3,525,214
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 14,469,496**
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   3,525,214
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          14,469,496**
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           17,994,710**
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           80.5% (46.8% of the outstanding voting power)**
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           IN
- -------------------------------------------------------------------------------
** Does not include any Note  Interest  Common  Shares.  As of December 31, 1997
Lindsay A. Rosenwald,  M.D. may be deemed beneficially to own (within the
meaning of Rule 13d-3 under the  Securities  Exchange  Act of 1934,  as amended)
573,777 Note Interest  Common  Shares.  
*** The  outstanding  shares  of  Series D  Preferred  Stock of the  Issuer  are
entitled  to vote  together  with the  holders  of Common  Stock on all  matters
submitted  to a vote of  stockholders  of the Issuer.  As of December  29, 1997,
Lindsay A. Rosenwald, M.D. may be deemed beneficially to own (within the meaning
of Rule 13d-3 under the Securities  Exchange Act of 1934, as amended)  46.8% of
the  aggregate  voting  power of the Common  Stock and Series D Preferred  Stock
outstanding.


<PAGE>

- -----------------------------------            ---------------------------------
          CUSIP No. 372 45 M 20 7      13D        Page 6 of 11 Pages
- -----------------------------------            ---------------------------------
                                            
- --------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Paramount Capital, Inc.
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [_]
- -------------------------------------------------------------------------------
    3      SEC USE ONLY

- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

             OO (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

              New York
- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          None
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 None
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   None 
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          None
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           None
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           None 
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           CO
- -------------------------------------------------------------------------------


<PAGE>

- --------------------------                       -------------------------------
CUSIP No. 372 45 M 20 7              13D                     Page 7 of 11 Pages
- --------------------------                       -------------------------------

- -------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Mr. Michael S. Weiss
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [x]
- -------------------------------------------------------------------------------
    3      SEC USE ONLY

- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

           PF (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          16,644
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 650,929**
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   16,644 
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          650,929**
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           677,573**
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           13.2% (2.9% of the outstanding voting power)**
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           IN
- -------------------------------------------------------------------------------

**  Includes  650,929  shares  underlying  Placement  Warrants  and/or  Advisory
Warrants held by Hawkins Group,  LLC, a limited  liability  company of which Mr.
Weiss is a managing member.
*** The  outstanding  shares  of  Series D  Preferred  Stock of the  Issuer  are
entitled  to vote  together  with the  holders  of Common  Stock on all  matters
submitted to a vote of stockholders of the Issuer.  As of December 29, 1997, Mr.
Michael S. Weiss may be deemed  beneficially  to own (within the meaning of Rule
13d-3 under the  Securities  Exchange Act of 1934,  as amended) than 2.9% of the
aggregate  voting  power  of the  Common  Stock  and  Series D  Preferred  Stock
outstanding.


<PAGE>

                                  SCHEDULE 13D

         This Amendment No. 4 amends and  supplements the following Items of the
Reporting  Persons'  Statement on Schedule  13D,  dated  February  24, 1997,  as
amended to date, (the "Schedule").

Item 3. Source and Amount of Funds or Other Consideration

         The  information  contained in Item 3 to the Schedule is hereby amended
by adding the following:

         On December  2, 1997,  Aries Trust and Aries  Domestic  entered  into a
Letter Agreement  whereby they purchased an aggregate of 54,000 shares of Series
A  Convertible  Preferred  Stock,  par value $.001 per share (Series A Preferred
Stock) of the  Issuer  from  various  holders  thereof.  Each  share of Series A
Preferred  Stock,  together  with  accrued but unpaid  interest  thereon,  has a
liquidation value of $60.00. The Series A Preferred Stock is convertible, at the
option of the  holder,  into  Common  Stock at a  conversion  price of $8.27 per
share.  Aries Trust used  $261,986.30  of its general  funds to purchase  36,000
shares of Series A Preferred  Stock,  which shares are convertible  into 261,185
shares of Common Stock.  Aries Domestic used $130,993.14 of its general funds to
purchase 18,000 shares of Series A Preferred Stock, which shares are convertible
into  130,593  shares of Common  Stock.  On  December 29, 1997,  PCI  designated
recipients (the  "Paramount  Warrant  Designees") of the Placement  Warrants and
Advisory Warrants. Aries Trust, Aries Domestic, Dr. Rosenwald and Mr. Weiss were
among the Paramount Warrant Designees and each received such Placement  Warrants
and Advisory  Warrants in connection with the Private  Placement,  for which PCI
acted as placement agent (see Item 5).

Item 5. Interest in Securities of Issuer.

         The  information  contained in Item 5 to the Schedule is hereby amended
and supplemented to read in its entirety as follows:

     (a)  As of December 29, 1997:  Dr.  Rosenwald,  as the sole  shareholder of
          Paramount Capital and as the holder of Placement Warrants and Advisory
          Warrants, may be deemed beneficially to own 17,994,710 shares or 80.5%
          of the Issuer's  Common Stock (not including any Note Interest  Common
          Shares); PCI, through its allocation of the Placement Warrants and the
          Advisory  Warrants to Paramount  Warrant Designees (as defined below),
          may be deemed  beneficially  to own no shares of the  Issuer's  Common
          Stock;  Paramount  Capital,  through the acquisitions of securities by
          Aries  Trust and Aries  Domestic,  may be deemed  beneficially  to own
          14,469,496 shares or 64.7% of the Issuer's Common Stock (not including
          any Note Interest Common Shares); and Aries Domestic,  Aries Trust and
          Mr. Weiss may be deemed  beneficially to own the following  numbers of
          shares of Common Stock (in each case,  not including any Note Interest
          Common Shares):

                     Aries Domestic            5,053,220
                     Aries Trust               9,416,276
                     Mr. Weiss                   677,533


                               Page 8 of 11 Pages

<PAGE>

          Pursuant to Rule 13d-4 promulgated  under the Securities  Exchange Act
          of 1934, as amended,  the Filing Persons disclaim beneficial ownership
          of all the Common Stock except the Purchased Common Stock. Pursuant to
          Rule 13d-4 promulgated  under the Securities  Exchange Act of 1934, as
          amended,  the Aries  Reporting  Persons  and Mr.  Weiss each  disclaim
          beneficial ownership of all securities held by the other.

          The  outstanding  shares of Series D Preferred Stock of the Issuer are
          entitled  to vote  together  with the  holders of Common  Stock on all
          matters  submitted  to a vote of  stockholders  of the  Issuer.  As of
          December 29, 1997, Dr.  Rosenwald and Paramount  Capital may be deemed
          beneficially  to own  (within  the  meaning  of Rule  13d-3  under the
          Securities  Exchange  Act  of  1934,  as  amended)  46.8%  and  37.7%,
          respectively,  of the  aggregate  voting power of the Common Stock and
          Series D Preferred Stock  outstanding (not including any Note Interest
          Common Shares).

     (b)  Dr.  Rosenwald  and  Paramount  Capital  share the power to vote or to
          direct the vote,  to dispose  or to direct  the  disposition  of those
          shares owned by each of Aries Domestic and Aries Trust.  Dr. Rosenwald
          has the sole  power to vote or to direct the vote and to dispose or to
          direct the disposition of the shares underlying the Placement Warrants
          and  Advisory  Warrants  held by him.  Mr. Weiss has the sole power to
          vote or to direct the vote and to dispose or to direct the disposition
          of the shares  that he owns and has shares  power to vote or to direct
          the vote and to  dispose or to direct  the  disposition  of the shares
          underlying  the  Placement  Warrants  and  Advisory  Warrants  held by
          Hawkins Group, LLC.

     (c)  Other than the  purchase  of Series A  Preferred  Stock on December 2,
          1997 (see  Item 3) and  PCI's  designation  of  recipients  of all the
          Placement  Warrants and the Advisory  Warrants and Aries Trust,  Aries
          Domestic, Dr. Rosenwald and Mr. Weiss being among those so designated,
          (see  Item  3),  the  Reporting   Persons  have  not  engaged  in  any
          transactions  in the  Common  Stock of the Issuer in the past 60 days,
          except  to the  extent  that the  accrual  of  interest  on the  Notes
          pursuant to their terms may be deemed a transaction.

     (d)  Not applicable.

     (e)  As of December 29, 1997, PCI ceased to be the beneficial owner of more
          than 5% of the Common  Stock,  when it  designated  recipients  of the
          Placement Warrants and Advisory Warrants. Aries Trust, Aries Domestic,
          Dr.  Rosenwald  and were  designated  as the  recipients  of Placement
          Warrants  and/or  Advisory  Warrants.  The  number of shares of Common
          Stock issuable upon exercise of the Class D Warrants and conversion of
          the Series D Preferred Stock issuable upon exercise of Dr. Rosenwald's
          and Mr. Weiss'  Placement  Warrants and Advisory  Warrants are 72,399,
          38,984, 3,525,214 and 650,929 shares, respectively.


                               Page 9 of 11 Pages

<PAGE>

Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to
        Secuirities of the Issuer.

         The  information  contained in Item 6 to the Schedule is hereby amended
by adding the following:

         On December  2, 1997,  Aries Trust and Aries  Domestic  entered  into a
Letter  Agreement,  pursuant to which Aries  Trust,  Aries  Domestic and a third
party purchased shares of Series A Preferred Stock (see Item 3).

Item 7. Material to be Filed as Exhibits.

         The  information  contained in Item 7 to the Schedule is hereby amended
by adding the following:

         Exhibit Z:       Letter  Agreement  between  Aries  Trust,
                          Aries Domestic and third parties relating to 
                          the purchase of  Series  A Preferred Stock.


                               Page 10 of 11 Pages

<PAGE>

                                   SIGNATURES

         After  reasonable  inquiry and to the best  knowledge and belief of the
undersigned,  the  undersigned  certify that the  information  set forth in this
statement is true, complete and correct.

                    PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:   December 29, 1997
         New York, NY            By: /s/ Lindsay A. Rosenwald
                                     ---------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President

                                 ARIES DOMESTIC FUND, L.P.
                                 By: Paramount Capital Asset Management, Inc.
                                 General Partner

Dated:   December 29, 1997
         New York, NY             By: /s/ Lindsay A. Rosenwald
                                     ---------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President


                                 THE ARIES TRUST
                                 By: Paramount Capital Asset Management, Inc.
                                 General Partner

Dated:   December 29, 1997
         New York, NY             By: /s/ Lindsay A. Rosenwald
                                     ---------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President


Dated:   December 29, 1997
         New York, NY             By: /s/ Lindsay A. Rosenwald
                                     ---------------------------------------
                                     Lindsay A. Rosenwald, M.D.



Dated:   December 29, 1997
         New York, NY             By: /s/ Michael S. Weiss
                                     ---------------------------------------
                                     Mr. Michael S. Weiss


                               Page 11 of 11 Pages

<PAGE>

                                                                       EXHIBIT Z

                                December 2, 1997

VIA FACSIMILE
- -------------

Zesiger Capital Group LLC
320 Park Avenue
New York, NY 10022
ATTN: Albert L. Zesiger

                    Re: Letter Agreement
                        ----------------

         This  letter  agreement  (the   "Agreement")   sets  forth  the  entire
understanding among the Aries Fund, a Series of The Aries Trust, a Cayman Island
Trust  (the  "Trust"),  the  Aries  Domestic  Fund,  L.P.,  a  Delaware  limited
partnership (the  "Partnership",  and collectively with the Trust, the "Funds"),
Mr. Sydney Kimmel ("Kimmel",  and collectively with the Funds, the "Purchasers")
Zesiger Capital Group,  L.L.C. (the "Advisor") and the Sellers listed on Exhibit
A, hereto  (each of which is herein  referred to as a "Seller")  with respect to
the purchase of an aggregate of 107,800 shares of Series A Preferred  Stock (the
"Shares")  of Genta  Incorporated  (the  "Company")  (together  with any and all
rights, claims and causes of action of any kind, known or unknown, contingent or
mature arising out of or relating to Seller's acquisition,  ownership or sale of
such Shares which such Seller has or may have  against the  Company,  the Funds,
Paramount  Capital,  Inc.,  Paramount Capital Asset  Management,  Inc. or any of
their respective present or former officers, directors, employees, shareholders,
affiliates,   agents  or  advisors  (other  than  claims  arising  out  of  this
Agreement)) by the Funds and Kimmel from the Sellers:

Purchasers:                        The Aries Fund, a Series of The Aries
                                   Trust, a Cayman Island Trust

                                   The Aries Domestic Fund, L.P., a Delaware
                                   limited partnership

                                   Mr. Sydney Kimmel

                                   The allocation as between the Trust,
                                   the  Partnership  and  Kimmel is set
                                   forth on Exhibit A attached hereto.

Aggregate Price:                   $784,503.42


<PAGE>

Transaction:                       Subject to the terms and conditions set
                                   forth herein, the Seller hereby agrees to
                                   sell and transfer to the Purchasers, and
                                   the Purchasers hereby agree to purchase
                                   from the Seller in the amounts set forth
                                   on Exhibit A hereto, the Shares (together
                                   with any and all rights, claims and
                                   causes of action of any kind, known or
                                   unknown, contingent or matured, arising
                                   out of or relating to Seller's
                                   acquisition, ownership of sale of such
                                   Shares which such Seller has or may have
                                   against the Company, the Funds, Paramount
                                   Capital, Inc., Paramount Capital Asset
                                   Management, Inc. or any of their
                                   respective present or former officers,
                                   directors, employees, shareholders,
                                   affiliates, agents or advisors (other
                                   than claims arising out of this
                                   agreement)) at the Closing (as defined
                                   below) for the Aggregate Price set forth
                                   above.  At such Closing, the Seller, or
                                   its nominee, will deliver to the Funds
                                   certificates for the Shares with duly
                                   endorsed stock powers, against payment of
                                   the purchase price therefor by the Funds,
                                   by wire transfer or certified check
                                   payable to the Seller.

Closing:                           The Closing  shall take place at the
                                   officers of Proskauer Rose LLP, 1585
                                   Broadway,  New York, New York on the
                                   date  hereof or at such  other  time
                                   and place as  mutually  agreed to by
                                   the parties.

Conditions to Purchasers'
Obligations:                       The obligation of the Purchasers to
                                   purchase and pay for the Shares at the
                                   Closing is subject to the satisfaction on
                                   or prior to the date of the Closing of
                                   the following conditions, which may only
                                   be waived by written consent of the
                                   Purchasers:


                                      - 2 -

<PAGE>

                                   (a) all of the  representations  and
                                   warranties  of the Seller  contained
                                   in this Agreement  shall be true and
                                   correct at and as of the date of the
                                   Closing  with the same  effect as if
                                   made  on the  date  of the  Closing,
                                   except  to  the  extent  of  changes
                                   caused    by    the     transactions
                                   contemplated hereby;

                                   (b)   all  of  the   covenants   and
                                   agreements  of the Seller  contained
                                   in this Agreement and required to be
                                   performed on or prior to the date of
                                   the   Closing    shall   have   been
                                   performed  in a manner  satisfactory
                                   in all respects to the Purchasers;

                                   (c) no action or  proceeding  before
                                   any court or governmental body shall
                                   be pending or threatened  wherein an
                                   unfavorable judgment decree or order
                                   would  prevent the  carrying  out of
                                   this   Agreement   or   any  of  the
                                   transactions   contemplated  hereby,
                                   declare  unlawful  the  transactions
                                   contemplated  by this  Agreement  or
                                   cause   such   transactions   to  be
                                   rescinded; and

                                   (d)  the   Purchasers   shall   have
                                   received     such      certificates,
                                   assignments of rights and such other
                                   documents  and  instruments  as  the
                                   Purchasers may reasonably request in
                                   connection with, and to effect,  the
                                   transactions  contemplated  by  this
                                   Agreement.

Conditions to Seller's
Obligations:                       The obligation of the Seller to sell the
                                   Shares to Purchasers as set forth herein
                                   at the Closing is subject to the
                                   satisfaction on or prior to the date of
                                   the Closing of the following conditions,
                                   any of which may be waived by the Seller:

                                   (a)   all  of  the   covenants   and
                                   agreements    of   the    Purchasers
                                   contained  in  this   Agreement  and
                                   required to performed on or prior to
                                   the date of the  Closing  shall have
                                   been    performed    in   a   manner
                                   satisfactory  in all respects to the
                                   Sellers;


                                      - 3 -

<PAGE>

                                   (b)    the    representations    and
                                   warranties    of   the    Purchasers
                                   contained in this Agreement shall be
                                   true  and  correct  at and as of the
                                   date of the  Closing  with  the same
                                   effect as if made on the date of the
                                   Closing,  except  to the  extent  of
                                   changes  caused by the  transactions
                                   contemplated hereby; and

                                   (c) no action or  proceeding  before
                                   any court or governmental body shall
                                   be pending or threatened  wherein an
                                   unfavorable   judgment,   decree  or
                                   order would prevent the carrying out
                                   of  this  Agreement  or  any  of the
                                   transactions   contemplated  hereby,
                                   declare  unlawful  the  transactions
                                   contemplated  by this  Agreement  or
                                   cause   such   transactions   to  be
                                   rescinded.

Sellers' Representations
and Warranties:                    Each Seller represents and warranties to
                                   the Purchaser acquiring its shares
                                   hereunder as follows:

                                   (a) the  Seller  has full  power and
                                   authority   to   enter   into   this
                                   Agreement   and   to   perform   its
                                   obligations     hereunder.      This
                                   Agreement constitutes a legal, valid
                                   and binding obligation of the Seller
                                   enforceable  in accordance  with its
                                   terms  and  conditions.  The  Seller
                                   need not give any  notice  to,  make
                                   any  filing  with,   or  obtain  any
                                   authorization,  consent or  approval
                                   of any  government  or  governmental
                                   agency  in order to  consummate  the
                                   transactions  contemplated  by  this
                                   Agreement;

                                   (b)   neither  the   execution   and
                                   delivery of this Agreement,  nor the
                                   consummation  of  the   transactions
                                   contemplated    hereby,   will   (i)
                                   violate   any   provision   of   the
                                   Seller's charter or bylaws,  or (ii)
                                   conflict   with,   result   in   the
                                   acceleration of, create in any party
                                   the right to accelerate,  terminate,
                                   modify, cancel or require any notice
                                   under   any   agreement,   contract,
                                   lease, license,  instrument or other
                                   arrangement to which the Seller is a
                                   party or by which the


                                      - 4 -

<PAGE>

                                   Seller is bound or to which any of its
                                   assets is subject;

                                   (c) the Seller has no  obligation to
                                   pay any fees or  commissions  to any
                                   broker,   finder,  agent,  financial
                                   person  or other  intermediary  with
                                   respect    to    the    transactions
                                   contemplated  by this  Agreement for
                                   which the  Purchasers  could  become
                                   liable;

                                   (d)  the  Seller  is the  holder  of
                                   record  of, and  beneficially  owns,
                                   the  Shares  free  and  clear of any
                                   restrictions on transfer (other than
                                   any  restrictions  under the Act (as
                                   defined below), and state securities
                                   laws),  taxes,  security  interests,
                                   warrants,  options, purchase rights,
                                   contracts,  commitments,   equities,
                                   claims  and  demands.  The Seller is
                                   not a party to any option,  warrant,
                                   purchase right, or other contract or
                                   commitment  that could  require  the
                                   Seller   to   sell,    transfer   or
                                   otherwise  dispose  of  any  capital
                                   stock  of the  Company  (other  than
                                   this Agreement). The Seller is not a
                                   party to any voting trust, proxy, or
                                   other  agreement  or   understanding
                                   with  respect  to the  voting of any
                                   capital stock of the Company. All of
                                   the Shares are validly issued, fully
                                   paid and non-assessable;

                                   (e)   the   rights    assigned   and
                                   transferred  by  the  Seller  to the
                                   Purchasers    pursuant    to    this
                                   Agreement     shall     be,     upon
                                   consummation    of   the    Closing,
                                   enforceable  against  the Company by
                                   the  Funds  as  assignee  of  Seller
                                   after  the  date of the  Closing  in
                                   accordance with the terms hereof.

Advisor's
Representations
and Warranties:                    The Advisor represents and warrants to
                                   the Purchasers as follows:

                                   (a) the  Advisor  has full power and
                                   authority   to   enter   into   this
                                   Agreement  on behalf of the  Sellers
                                   and  to  bind  the  Sellers  to  the
                                   obligations and agreements


                                      - 5 -

<PAGE>

                                   contained herein; and

                                   (b) the  Advisor  has  discretionary
                                   investment authority with respect to
                                   the   Shares   and  has   the   full
                                   irrevocable  power  to  act  on  the
                                   Seller's as true and lawful attorney
                                   in  fact  pursuant  to   appropriate
                                   legal documentation  provided to the
                                   Purchasers.

The Purchasers'
Representations
and Warranties:                    The Purchasers represent and warrant to
                                   the Sellers as follows:

                                   (a) the  Purchasers  have full power
                                   and  authority  to enter  into  this
                                   Agreement   and  to  perform   their
                                   obligations     hereunder.      This
                                   Agreement constitutes a legal, valid
                                   and  binding  obligation  of each of
                                   the   Purchasers,   enforceable   in
                                   accordance   with  its   terms   and
                                   conditions.  The Purchasers need not
                                   give any notice to,  make any filing
                                   with,  or obtain any  authorization,
                                   consent   or    approval    of   any
                                   government or governmental agency in
                                   order to consummate the transactions
                                   contemplated by this Agreement;

                                   (b)   neither  the   execution   and
                                   delivery of this Agreement,  nor the
                                   consummation  of  the   transactions
                                   contemplated    hereby,   will   (i)
                                   violate any  provision of the Funds'
                                   certificate of limited  partnership,
                                   partnership  agreement,  declaration
                                   of trust,  trust  agreement or other
                                   organizational   document,  or  (ii)
                                   conflict   with,   result   in   the
                                   acceleration of, create in any party
                                   the right to accelerate,  terminate,
                                   modify, cancel or require any notice
                                   under   any   agreement,   contract,
                                   lease, license,  instrument or other
                                   arrangement  to  which  any  of  the
                                   Purchasers  is a party  or by  which
                                   any of the Purchasers is bound or to
                                   which any of its assets is subject;

                                   (c)   the    Purchasers    have   no
                                   obligation   to  pay  any   fees  or
                                   commissions  to any broker,  finder,
                                   agent,  financial  person  or  other
                                   intermediary with respect to the


                                      - 6 -

<PAGE>

                                   transactions contemplated by this
                                   Agreement for which the Seller could
                                   become liable;

                                   (d) the Purchasers are not acquiring
                                   the  Shares  with a view to, or for,
                                   sale   in   connection    with   any
                                   distribution   thereof   within  the
                                   meaning  of  the  Act.  Each  of the
                                   Purchasers  is acquiring  the Shares
                                   to be  purchased  by it for  its own
                                   account,  beneficially  and not as a
                                   nominee  for or for the  account  of
                                   another.  Each of the  Purchasers is
                                   an "accredited  investor" within the
                                   meaning of  Regulation D promulgated
                                   under the Securities Act of 1933, as
                                   amended (the  "Act");  Kimmel has an
                                   individual  net  worth in  excess of
                                   $1,000,000,    is   an   experienced
                                   investor in  securities of companies
                                   like the Company,  understands  that
                                   the   Shares    are   an    illiquid
                                   investment  which  may not be resold
                                   without  an  effective  registration
                                   statement    or    exemption    from
                                   registration  being  available under
                                   the Act,  and can  afford a complete
                                   loss  of  his   investment   in  the
                                   Shares; and

                                   (e) the  Purchasers  have received a
                                   copy   of   the   Prospectus   dated
                                   February 1, 1996 covering the resale
                                   of the Shares.

Additional Provision:              Each of the Sellers and the Advisor and
                                   its personnel responsible for managing
                                   and conducting its affairs (i) have been
                                   afforded an opportunity to make such
                                   inquiry regarding the business and
                                   affairs of the Company as they have
                                   deemed appropriate, (ii) have made a
                                   thorough investigation of the prospects
                                   of the Company, (iii) acknowledge and
                                   understand that the Funds have previously
                                   made and retain a substantial investment
                                   in the Company, and may have superior
                                   access to information regarding its
                                   affairs and prospects which, if known to
                                   the Sellers, might be material to the
                                   Sellers decisions to enter into this
                                   Agreement, (iv) acknowledge and under-
                                   stand that the Funds may possess and may
                                   come into possession of certain
                                   information which is not known to the


                                      - 7 -

<PAGE>

                                   Sellers  and the  Advisor  and which
                                   may be  material  to a  decision  to
                                   acquire and/or sell the Shares,  and
                                   (v)   have   such    knowledge   and
                                   experience in financial and business
                                   matter  to enable  them to  evaluate
                                   the   merits   and   risks   of  the
                                   transactions  contemplated  by  this
                                   Agreement.

Covenants of the
Seller:                            (a)  Until closing, the Sellers shall
                                   take no action to enforce their rights as
                                   Series A or common stockholders (i) under
                                   the Company's Amended and Restated
                                   Articles of Incorporation, (ii) pursuant
                                   to the Unit Purchase Agreement (as de-
                                   fined below) or (iii) by contract, at
                                   common law, by statute, rule or
                                   regulation or otherwise at law or equity,
                                   with respect to the Shares (including any
                                   common stock into which the Shares are
                                   convertible).

                                   (b) Along with the  transfer  of the
                                   Shares, the Seller hereby assigns to
                                   the Funds the following rights:  (a)
                                   all  rights  of  Seller   under  the
                                   September  23,  1993  Unit  Purchase
                                   Agreement,  pursuant  to  which  the
                                   Seller  purchased  the  Shares  (the
                                   "Unit  Purchase  Agreement"),   with
                                   respect  to  the  Shares;   (b)  all
                                   rights of the Seller  granted to the
                                   Seller under the  Company's  Amended
                                   and     Restated     Articles     of
                                   Incorporation   and/or  bylaws  with
                                   respect  to  the  Shares;   (c)  all
                                   rights,  claims and causes of action
                                   of  any  kind,   known  or  unknown,
                                   contingent  or matured,  arising out
                                   of   or    relating    to   Seller's
                                   acquisition,  ownership  or  sale of
                                   such Shares which such Seller has or
                                   may have  against the  Company,  the
                                   Funds,   Paramount  Capital,   Inc.,
                                   Paramount  Capital Asset Management,
                                   Inc.  or  any  of  their  respective
                                   present    or    former    officers,
                                   directors, employees,  shareholders,
                                   affiliates,   agents   or   advisors
                                   (other  than  claims  arising out of
                                   this  agreement))  and (d) any other
                                   rights of the Seller with respect to
                                   the Shares  whether by contract,  at
                                   common  law,  by  statute,  rule  or
                                   regulation or otherwise


                                      - 8 -

<PAGE>

                                   at law or equity.

Non-solicitation:                  Pending the Closing, the Sellers shall
                                   not, directly or indirectly, through any
                                   officer, director, agent or otherwise,
                                   negotiate or discuss with any third
                                   party, any proposal with respect to a
                                   sale or any other transaction regarding
                                   the Shares or the shares of common stock
                                   underlying the Shares, other than to
                                   notify the Company of the Seller's intent
                                   to sell as required in the Unit Purchase
                                   Agreement.

Miscellaneous:                     (a)   All representations, warranties,
                                   covenants and agreements contained in
                                   this Agreement, or in any document,
                                   exhibit, schedule or certificate by any
                                   party delivered in connection herewith
                                   shall survive the execution and delivery
                                   of this Agreement and the date of the
                                   Closing and the consummation of the
                                   transactions contemplated hereby,
                                   regardless of any investigation made by
                                   any of the Purchasers or Sellers or on
                                   their behalf.

                                   (b) The  parties  hereto  shall  not
                                   disclose  to any  (other  than their
                                   respective  advisors) the content or
                                   the   existence   of   this   letter
                                   agreement   or   the    transactions
                                   contemplated  herein,  except as may
                                   be required by law,  until such time
                                   as a closing has occurred.

                                   (c)   The   validly,    performance,
                                   construction   and  effect  of  this
                                   Agreement  shall be  governed by the
                                   internal  laws of the  State  of New
                                   York   without   giving   effect  to
                                   principles of conflicts of law.


                                      - 9 -

<PAGE>

         This letter shall  constitute the definitive  agreement with respect to
the purchase of the Shares and is intended to be binding  upon the  parties.  If
the foregoing  accurately  reflects your  understanding  of the definitive terms
pursuant  to which the  Purchasers  will  acquire the above  referenced  Shares,
please so indicate by signing this letter  agreement on the space provided below
and returning a facsimile copy of this letter to us at (212) 554-4355, whereupon
this Agreement shall constitute a binding agreement among us.

                              Sincerely,

                              THE ARIES TRUST

                              By:  /s/ Lindsay A. Rosenwald, M.D.
                                   ------------------------------
                                   Lindsay A. Rosenwald, M.D., President
                                   Paramount Capital Asset Management, Inc.
                                   Investment Advisor to The Aries Trust

                              ARIES DOMESTIC FUND, L.P.

                              By:  /s/ Lindsay A. Rosenwald, M.D.
                                   ------------------------------
                                   Lindsay A. Rosenwald, M.D., President
                                   Paramount Capital Asset Management, Inc.
                                   General Partner, Aries Domestic Fund L.P.




                                   ---------------------------------------
                                   Sydney Kimmel


AGREED TO AND ACCEPTED AS OF
THE DATE FIRST WRITTEN ABOVE:

ZESIGER CAPITAL GROUP LLC, as agent and  attorney-in-fact for the Sellers listed
on Exhibit A attached hereto



By:  
     ----------------------
     Name:
     Title:


                                     - 10 -


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