GENTA INCORPORATED /DE/
8-K, 1997-02-28
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                    FORM 8-K

                                 CURRENT REPORT


     PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934


       Date of Report (Date of earliest event reported): January 28, 1997


                               GENTA INCORPORATED
             (Exact name of registrant as specified in its charter)


                         Commission file number 0-19635


            DELAWARE                                     33-0326866
 (State or other jurisdiction of            (IRS Employer Identification Number)
 incorporation or organization)

                 3550 GENERAL ATOMICS COURT, SAN DIEGO, CA 92121
                    (Address of principal executive offices)
                                   (Zip Code)

                                 (619) 455-2700
              (Registrant's telephone number, including area code)


<PAGE>


                               GENTA INCORPORATED

                                    FORM 8-K

                                 CURRENT REPORT

                                TABLE OF CONTENTS


Item 5.  Other Events

Item 7.  Financial Statements and Exhibits

Signature


                                      - 2 -


<PAGE>

ITEM 5.  OTHER EVENTS

         Effective as of the close of business on January 28,  1997,  David Hale
resigned from the Company's Board of Directors.

         On February 6, 1997, the Company announced that,  effective February 7,
1997, the Company's Common Stock, formerly listed on The Nasdaq National Market,
would be listed on The  Nasdaq  SmallCap  Market via an  exception  from the bid
price and  capital  and  surplus  requirements  of The Nasdaq  SmallCap  Market.
Although the Company failed to meet these  requirements  as of February 4, 1997,
it was  granted a  temporary  exception  from  these  standards  subject  to the
Company's meeting certain conditions. In the event the Company is deemed to have
met the terms of the  exception,  it shall  continue  to be listed on The Nasdaq
SmallCap  Market.  The Company  believes that it can meet these terms,  however,
there can be no assurance that the Company will be able to comply with the terms
of the exception.  If at some future date the Company's  securities should cease
to be listed on The Nasdaq  SmallCap  Market,  they may continue to be listed on
the OTC Bulletin Board. For the duration of the exception,  the Company's Nasdaq
symbol will be GNTAC.

         Genta Incorporated (the "Company")  announced on February 13, 1997 that
The Aries  Fund and The Aries  Domestic  Fund,  L.P.  (collectively  the  "Aries
Funds")  had  invested a total of  $3,000,000  in the  Company.  As part of this
transaction  (the  "Transaction"),  the  Company  issued to the Aries  Funds (i)
Senior  Secured  Convertible  Bridge Notes (the  "Notes"),  which are  initially
convertible  into  600,000  shares of Series D Preferred  Stock (the  "Preferred
Stock"),  which are in turn  initially  convertible  into  20,000,000  shares of
Common Stock, subject to antidilution adjustments, and (ii) warrants to purchase
an additional 20,000,000 shares of Common Stock. Further, upon the occurrence of
certain events of default, if elected by the holders, a portion of the Notes are
convertible into the number of shares of Common Stock determined by dividing the
amount  converted by $.001 per share.  Pursuant to the Note and Warrant Purchase
Agreement set forth in Exhibit 10.1, the Aries Funds have the right to appoint a
majority  of the members of the Board of  Directors  of the  Company;  provided,
however,  that in the event the Company has not obtained  Future  Financings (as
defined in the Note and Warrant  Purchase  Agreement) in excess of $3,500,000 on
or before the date which is six months after the Bridge Closing Date referred to
therein,  then the Aries Funds shall have the contractual  right to appoint only
two directors or observers  and, if additional  directors  have been  appointed,
they shall be  required to resign.  To date the Aries  Funds have not  exercised
such right.

         The  Aries  Funds  presently  own  915,000  shares  (or  2.3%)  of  the
outstanding  Common  Stock.  Through  conversion  of the Notes and the Preferred
Stock  and the  exercise  of the  warrants,  the Aries  Funds  have the right to
acquire  an  additional  40,000,000  shares  of Common  Stock  and  accordingly,
pursuant to Rule 13d-3 under the  Securities  Exchange Act of 1934,  as amended,
the Aries Funds may be deemed to beneficially own 51.1% of the Common Stock.

         Following  announcement  of the  Transaction,  two  stockholders of the
Company filed suit in the Delaware  Court of Chancery  against the Company,  its
directors and the Aries Funds  challenging the Transaction.  The complaint seeks
an  injunction,  unspecified  damages,  attorneys'  fees and other  relief.  The
Company  believes  that the  lawsuit  is without  merit,  and that it intends to
vigorously defend such action.

ITEM 7.  FINANCIAL STATEMENTS AND EXHIBITS

         (c)      Exhibits

3(i)  Certificate of Designations of Series D Convertible Preferred Stock of the
      Company.

10.1  Note and Warrant  Purchase  Agreement dated as of January 28, 1997, by and
      among the Company, The Aries Fund, A Cayman Island Trust (the "Trust") and
      The Aries Domestic Fund, L.P. (the "Partnership").

10.2  Letter dated January 28, 1997 from Genta Incorporated.

10.3  Senior  Secured  Convertible  Bridge Note of the Company dated January 28,
      1997 for $1,050,000.

10.4  Senior  Secured  Convertible  Bridge Note of the Company dated January 28,
      1997 for $1,950,000.


                                      - 3 -


<PAGE>

10.5  Class A Bridge Warrant of the Company for the purchase of 2,730,000 shares
      of Common Stock.

10.6  Class A Bridge Warrant of the Company for the purchase of 5,070,000 shares
      of Common Stock.

10.7  Class B Bridge Warrant of the Company for the purchase of 4,270,000 shares
      of Common Stock.

10.8  Class B Bridge Warrant of the Company for the purchase of 7,930,000 shares
      of Common Stock.

10.9  Security  Agreement  dated as of January 28, 1997  between the Company and
      Paramount Capital, Inc.

10.10 Letter  Agreement  dated  January  28, 1997 among the  Company,  Paramount
      Capital, Inc., the Partnership and the Trust.

10.11 Amendment No. 1, dated as of January 28, 1997, to Rights Agreement,  dated
      as of December 16, 1997,  between the Company and ChaseMellon  Shareholder
      Services L.L.C.


                                      - 4 -


<PAGE>


                                    SIGNATURE


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                                  GENTA INCORPORATED

                                                  /s/ Thomas H. Adams
Date:  February 25, 1997                          --------------------------
                                                     Thomas H. Adams
                                                    Chairman of the Board and
                                                    Chief Executive Officer


                                      - 5 -


<PAGE>

                                  EXHIBIT INDEX

Exhibit
Number   Description


3(i)  Certificate of Designations of Series D Convertible Preferred Stock of the
      Company.

10.1  Note and Warrant  Purchase  Agreement dated as of January 28, 1997, by and
      among the Company, The Aries Fund, A Cayman Island Trust (the "Trust") and
      The Aries Domestic Fund, L.P. (the "Partnership").

10.2  Letter dated January 28, 1997 from Genta Incorporated.

10.3  Senior  Secured  Convertible  Bridge Note of the Company dated January 28,
      1997 for $1,050,000.

10.4  Senior  Secured  Convertible  Bridge Note of the Company dated January 28,
      1997 for $1,950,000.

10.5  Class A Bridge Warrant of the Company for the purchase of 2,730,000 shares
      of Common Stock.

10.6  Class A Bridge Warrant of the Company for the purchase of 5,070,000 shares
      of Common Stock.

10.7  Class B Bridge Warrant of the Company for the purchase of 4,270,000 shares
      of Common Stock.

10.8  Class B Bridge Warrant of the Company for the purchase of 7,930,000 shares
      of Common Stock.

10.9  Security  Agreement  dated as of January 28, 1997  between the Company and
      Paramount Capital, Inc.

10.10 Letter  Agreement  dated  January  28, 1997 among the  Company,  Paramount
      Capital, Inc., the Partnership and the Trust.

10.11 Amendment No. 1 dated as of January 28, 1997 to Rights Agreement, dated as
      of December  16,  1997,  between the Company and  ChaseMellon  Shareholder
      Services L.L.C.


                                      - 6 -




                           CERTIFICATE OF DESIGNATIONS

                                       of

                      SERIES D CONVERTIBLE PREFERRED STOCK

                                       of

                               GENTA INCORPORATED

                         Pursuant to Section 151 of the
                General Corporation Law of the State of Delaware

         GENTA INCORPORATED, a corporation organized and existing under the laws
of the State of Delaware (the "Corporation"), does hereby certify that, pursuant
to the authority  conferred on the Board of Directors of the  Corporation by the
Certificate  of   Incorporation,   as  amended  to  date  (the  "Certificate  of
Incorporation"),  of the  Corporation  and in accordance with Section 151 of the
General Corporation Law of the State of Delaware,  the Board of Directors of the
Corporation adopted the following resolution  establishing a series of 3,750,000
shares of Preferred Stock of the Corporation designated as "Series D Convertible
Preferred Stock":

                  RESOLVED,  that  pursuant to the  authority  conferred  on the
         Board  of  Directors  of  this   Corporation  by  the   Certificate  of
         Incorporation,  a series of Preferred Stock, par value $.001 per share,
         of the  Corporation  is hereby  established  and created,  and that the
         designation  and  number of shares  thereof  and the  voting  and other
         powers,  preferences  and  relative,  participating,  optional or other
         rights of the shares of such series and the qualifications, limitations
         and restrictions thereof are as follows:

                      Series D Convertible Preferred Stock

         1.  Designation and Amount.  There shall be a series of Preferred Stock
designated  as "Series D Convertible  Preferred  Stock" and the number of shares
constituting  such series shall be 3,750,000.  Such series is referred to herein
as the "Series D Preferred Stock".  Notwithstanding  any other provision in this
Certificate of  Designations  to the contrary,  such series shall be on a parity
with the Series A Preferred  Stock and Series C  Preferred  Stock of the Company
with respect to dividends,  distribution of assets, liquidation,  dissolution or
winding up. Such number of shares may be  increased  prior to the Final  Closing
Date (as defined  below) or decreased by resolution of the Board of Directors of
the Corporation;  provided, however, that no decrease shall reduce the number of
shares of Series D Preferred Stock to less than the number of shares then issued
and outstanding.


<PAGE>

         2.  Dividends and  Distributions.  (a) Commencing on the Reset Date (as
defined in Section  4(a)  below),  the holders of the Series D  Preferred  Stock
shall be  entitled  to receive  cumulative  dividends  on each share of Series D
Preferred Stock, payable in shares of Common Stock, at the rate of 10% per annum
(computed  on the  basis of a  360-day  year of  twelve  30 day  months)  of the
Dividend Base Amount (as defined below),  payable semi-annually in arrears. Such
dividends  shall  be paid in  additional  duly  authorized,  fully  paid and non
assessable shares of Common Stock. In calculating the number of shares of Common
Stock to be paid with respect to each dividend, each share of Common Stock shall
be deemed to have the value of the Conversion  Price (as defined in Section 4(a)
hereof) at the time such  dividend  is paid.  Such  dividends  shall  accrue and
accumulate  whether or not they have been  declared and whether or not there are
profits,  surplus or other funds of the  Corporation  legally  available for the
payment of  dividends.  The  "Dividend  Base  Amount"  shall be $14.00  plus all
accrued but unpaid dividends  (subject to appropriate  adjustment to reflect any
stock split,  combination,  reclassification  or  reorganization of the Series D
Preferred Stock).

               (b) In  addition  to the  foregoing,  subject  to the  prior  and
superior  rights of the  holders of any shares of any series or class of capital
stock ranking prior and superior to the shares of Series D Preferred  Stock with
respect to dividends, the holders of shares of Series D Preferred Stock shall be
entitled to receive,  as, when and if declared by the Board of  Directors of the
Corporation,  out of assets  legally  available for that  purpose,  dividends or
distributions in cash, stock or otherwise.

               (c)  The   Corporation   shall  not  declare   any   dividend  or
distribution  on any Junior Stock (as defined  below) of the Company  unless and
until a special  dividend  or  distribution  of $14.00  per  share  (subject  to
appropriate adjustment to reflect any stock split, combination, reclassification
or reorganization of the Series D Preferred Stock) has been declared and paid on
the Series D Preferred Stock. In the event such special dividend or distribution
is declared and paid on the Series D Preferred  Stock,  an  aggregate  per share
dividend  or  distribution  equal to (i) $14.00  divided  by (ii) the  effective
Conversion  Rate at the time of such  special  dividend or  distribution  on the
Series D Preferred Stock may be declared and paid on the Common Stock. Except as
aforesaid, the Corporation shall not declare any dividend or distribution on any
Junior  Stock or stock on parity with the Series D Preferred  Stock,  unless the
Corporation  shall,  concurrently  with  the  declaration  of such  dividend  or
distribution  on the Junior Stock or stock on parity with the Series D Preferred
Stock,  declare  a like  dividend  or  distribution,  as the case may be, on the
Series D Preferred Stock.

               (d) Any dividend or  distribution  (other than that referenced in
the first  sentence  of Section  2(b))  payable  to the  holders of the Series D
Preferred  Stock pursuant to this Section 2 shall be paid to such holders at the
same time as the  dividend  or  distribution  on the  Junior  Stock or any other
capital stock of the Company by which it is measured is paid.

               (e) All  dividends or  distributions  declared  upon the Series D
Preferred Stock shall be declared pro rata per share.


                                       -2-


<PAGE>

               (f) Any reference to  "distribution"  contained in this Section 2
shall not be deemed to include any  distribution  made in connection  with or in
lieu of any Liquidation Event (as defined below).

               (g) "Junior  Stock" shall mean the Common Stock and any shares of
preferred  stock of any series or class of the  Corporation,  whether  presently
outstanding  or  hereafter  issued,  which are  junior to the shares of Series D
Preferred Stock with respect to (i) the  distribution of assets on any voluntary
or involuntary liquidation,  dissolution or winding up of the Corporation,  (ii)
dividends  or (iii)  voting  except that the Junior  Stock shall not include the
Series A Preferred Stock of the Company.

         3.  Liquidation  Preference.  (a) In the  event  of a (i)  liquidation,
dissolution or winding up of the Corporation,  whether voluntary or involuntary,
(ii) a sale or other  disposition of all or  substantially  all of the assets of
the Corporation or (iii) any consolidation, merger, combination,  reorganization
or other transaction in which the Corporation is not the surviving entity or the
shares of Common Stock  constituting in excess of 50% of the voting power of the
Corporation  are  exchanged  for or changed into stock or  securities of another
entity, cash and/or any other property (a "Merger  Transaction")  (subparagraphs
(i), (ii) and (iii) being  collectively  referred to as a "Liquidation  Event"),
after  payment or provision  for payment of debts and other  liabilities  of the
Corporation,  the holders of the Series D Preferred Stock then outstanding shall
be  entitled  to be paid out of the  assets  of the  Corporation  available  for
distribution to its stockholders on a pari passu basis with the shares of Series
A Preferred  Stock and Series C Preferred  Stock of the  Company,  whether  such
assets are capital,  surplus, or earnings, before any payment or declaration and
setting  apart for payment of any amount  shall be made in respect of any Junior
Stock of the  Company,  an amount equal to $14.00 per share plus an amount equal
to all declared and/or unpaid dividends thereon; provided,  however, in the case
of a Merger  Transaction,  such  $14.00 per share may be paid in cash,  property
(valued as provided in Section  3(b)) and/or  securities  (valued as provided in
Section 3(b)) of the entity  surviving such Merger  Transaction.  In the case of
property or in the event that any such securities are  restricted,  the value of
such  property  or  securities  shall be  determined  by  agreement  between the
Corporation and a the holders of a majority of the Series D Preferred Stock then
outstanding.  If upon any Liquidation  Event,  whether voluntary or involuntary,
the assets to be dis  tributed to the  holders of the Series D  Preferred  Stock
shall be  insufficient  to permit the payment to such  shareholders  of the full
preferential amounts aforesaid,  then all of the assets of the Corporation to be
distributed  shall be so  distributed  ratably  to the  holders  of the Series D
Preferred Stock on the basis of the number of shares of Series D Preferred Stock
held.  A  consolidation  or  merger  of the  Corporation  with or  into  another
corporation,  other than in a transaction  described in this Section 3(a) above,
shall  not  be  considered  a  liquidation,  dissolution  or  winding  up of the
Corporation or a sale or other  disposition of all or  substantially  all of the
assets of the Corporation and accordingly the Corporation shall make appropriate
provision to ensure that the terms of this  Certificate of Designations  survive
any such  transaction.  All shares of Series D Preferred  Stock shall rank as to
payment upon the occurrence of any Liquidation  Event senior to the Common Stock
as provided herein,  on a pari passu basis with the shares of Series A Preferred
Stock and Series C Preferred Stock of the Company,  and unless the terms of such
series shall provide otherwise,  senior to all other series of the Corporation's
preferred stock.


                                       -3-


<PAGE>


         (b) Any  securities or other property to be delivered to the holders of
the Series D Preferred  Stock pursuant to Section 3(a) hereof shall be valued as
follows:

               (i)  Securities  not  subject  to an  investment  letter or other
               similar restriction on free marketability:

                    (A) If  traded on a  securities  exchange  or on Nasdaq  (as
                    defined below), or if actively traded over-the-counter,  the
                    value  shall be deemed to be the  Market  Price (as  defined
                    below)  of the  securities  as of the third day prior to the
                    date of valuation.

                    (B) If  there  is no  such  active  public  market  for  the
                    securities,  the value  shall be the Fair  Market  Value (as
                    defined below) of the securities.

               "Market Price" of a security  shall mean the average  Closing Bid
               Price of such security, for twenty (20) consecutive trading days,
               ending  with the day  prior to the  date as of which  the  Market
               Price is being determined.

               "Fair Market Value" of any asset  (including any security)  means
               the fair  market  value  thereof as  mutually  determined  by the
               Corporation  and the holders of a majority  (measured in terms of
               voting power) of the outstanding Series D Preferred Stock.

               The  "Closing  Bid Price" for any  security  for each trading day
               shall be the reported  closing bid price of such  security on the
               national  securities exchange on which such security is listed or
               admitted  to  trading,  or,  if such  security  is not  listed or
               admitted to trading on any national  securities  exchange,  shall
               mean the  reported  closing  bid  price of such  security  on the
               Nasdaq  SmallCap  Market or the  Nasdaq  National  Market  System
               (collectively  referred to as,  "Nasdaq") or, if such security is
               not listed or  admitted  to trading  on any  national  securities
               exchange or quoted on Nasdaq, shall mean the reported closing bid
               price of such  security on the principal  securities  exchange on
               which such  security is listed or  admitted to trading  (based on
               the aggregate  dollar value of all securities  listed or admitted
               to  trading)  or, if such  security  is not listed or admitted to
               trading on a national  securities  exchange,  quoted on Nasdaq or
               listed or admitted to trading on any other  securities  exchange,
               shall mean the closing bid price in the  over-the-counter  market
               as furnished by any NASD member firm  selected  from time to time
               by the Corporation for that purpose.

               "Trading day" shall mean a day on which the  securities  exchange
               or NASDAQ used to determine the Closing Bid Price is open for the
               transaction  of  business or the  reporting  of trades or, if the
               Closing  Bid  Price is not so  determined,  a day on  which  such
               securities exchange is open for the transaction of business.

               "Trading  Price" shall mean the lesser of (i) the average Closing
               Bid Price of the Common Stock for the thirty consecutive  trading
               days,  ending  with the day  prior  to the  date as of which  the
               Trading Price is being determined or (ii) the average Closing


                                       -4-


<PAGE>

               Bid Price of the Common  Stock for the five  consecutive  trading
               days,  ending  with the day  prior  to the  date as of which  the
               Trading Price is being determined.

               (ii) For  securities  for which there is an active  public market
               but  which  are  subject  to  an   investment   letter  or  other
               restrictions on free  marketability,  the value shall be the Fair
               Market Value thereof, determined by discounting appropriately the
               Market Price thereof.

               (iii)  For all  other  securities,  the  value  shall be the Fair
               Market Value thereof.

If the holders of a majority of the Series D Preferred Stock and the Corporation
are unable to reach agreement on any valuation  matter,  such valuation shall be
submitted to and determined by a nationally  recognized  independent  investment
bank selected by the Board of Directors of the  Corporation and the holders of a
majority of the Series D Preferred Stock (or, if such selection cannot be agreed
upon promptly,  or in any event within ten days,  then such  valuation  shall be
made by a nationally recognized  independent investment banking firm selected by
the American  Arbitration  Association  in New York City in accordance  with its
rules), the costs of which valuation shall be paid for by the Corporation.

               4. Conversion.

               (a) Right of Conversion.  The shares of Series D Preferred  Stock
shall be  convertible,  in whole or in part, at the option of the holder thereof
and upon notice to the  Corporation  as set forth in Section  4(b)  below,  into
fully paid and  nonassessable  shares of Common Stock and such other  securities
and property as hereinafter provided.  The initial conversion price per share of
Common  Stock  shall be equal to $0.30  (the  "Conversion  Price")  and shall be
subject to adjustment as provided herein. The rate at which each share of Series
D Preferred Stock is convertible at any time into Common Stock (the  "Conversion
Rate") shall be determined by dividing the then existing  Conversion  Price into
$10.00.

               Subject to adjustment  pursuant to the provisions of Section 4(c)
below,  in the  event  that the  Conversion  Price in  effect at the time of the
Initial Closing Date (as defined  below),  each Interim Closing Date (as defined
below) and the Final Closing Date (as defined  below) is greater than 50% of the
Trading  Price (as  defined in Section  3(b)) of the Common  Stock as of (x) the
initial closing date of the issuance and sale of Qualified  Offering  Securities
(as defined below) (the "Initial  Closing Date") (y) any interim closing date of
the issuance and sale of Qualified Offering Securities (each an "Interim Closing
Date") or (z) the  final  closing  date of the  issuance  and sale of  Qualified
Offering  Securities  (the "Final  Closing Date")  pursuant to the  subscription
agreements entered into in connection therewith, then the Conversion Price shall
be adjusted to equal 50% of the lesser of any such  Trading  Price.  If there is
any change in the Conversion Price as a result of the preceding  sentence,  then
the  Conversion  Rate  shall be  changed  accordingly  as set forth  above.  For
purposes of this Section 4, in the event the prices referenced in the definition
of Closing Bid Price in Section 3(b) cannot be determined,  the Trading Price of
the Common  Stock  shall be deemed to be the Fair  Market  Value (as  defined in
Section  3(b)) of the  Common  Stock as of the date of  determination.  "Initial
Closing  Date",  "Interim  Closing Date" and "Final Closing Date" as used herein
shall refer 


                                       -5-


<PAGE>

to the  initial,  interim  and final  closing  date,  respectively,  in the next
offering  (or  series of related  offerings)  of the  equity  securities  of the
Company  (or  any  securities  convertible  into  equity)  ("Qualified  Offering
Securities") with gross proceeds in excess of $2,500,000.

               The  Board  of  Directors  of  the  Corporation,  or a  committee
designated  by it for such  purpose,  may  specify an initial  conversion  price
applicable to the shares of Series D Preferred Stock issued at any closing lower
than the initial  conversion  price that would otherwise  obtain pursuant to the
preceding  paragraphs  and,  in the  event  an  initial  conversion  price is so
specified, it shall be applicable to all shares of the Series D Preferred Stock.

               The  Corporation  shall  prepare  a  certificate  signed  by  the
Chairman or  President,  and by the  Treasurer or an Assistant  Treasurer or the
Secretary  or an  Assistant  Secretary,  of the  Corporation  setting  forth the
Conversion Rate as of the Final Closing Date,  showing in reasonable  detail the
facts upon which such adjusted  Conversion Rate is based,  and such  certificate
shall  forthwith  be filed with the  transfer  agent of the  Series D  Preferred
Stock. A notice stating that the Conversion  Rate has been adjusted  pursuant to
the second preceding paragraph, or that no adjustment is necessary,  and setting
forth the Conversion Rate in effect as of the Final Closing Date shall be mailed
as promptly as  practicable  after the Final Closing Date by the  Corporation to
all record  holders of the Series D Preferred  Stock at their last  addresses as
they shall appear in the stock transfer books of the Corporation.

               The  Conversion  Price  (subject to  adjustments  pursuant to the
provisions of Section 4(c) below) in effect  immediately  prior to the date that
is 12 months after the Final Closing Date of the issuance and sale of the Series
D Preferred Stock (the "Reset Date") shall be adjusted and reset effective as of
the Reset Date if the Market Price as of the Reset Date (the  "12-Month  Trading
Price")  is less than  140% of the then  applicable  Conversion  Price (a "Reset
Event").  Upon the occurrence of a Reset Event,  the  Conversion  Price shall be
reduced to be equal to the greater of (A) the 12-Month  Trading Price divided by
1.40,  and (B) 50% of the  then  applicable  Conversion  Price.  If there is any
change in the Conversion Price as a result of the preceding  sentence,  then the
Conversion Rate shall be changed accordingly as set forth above. The Corporation
shall prepare a certificate  signed by the  principal  financial  officer of the
Corporation  setting forth the Conversion Rate as of the Reset Date,  showing in
reasonable  detail the facts upon which such Conversion Rate is based,  and such
certificate  shall  forthwith be filed with the  transfer  agent of the Series D
Preferred  Stock. A notice  stating that the  Conversion  Rate has been adjusted
pursuant to this  paragraph,  or that no adjustment  is  necessary,  and setting
forth the  Conversion  Rate in effect  as of the Reset  Date  shall be mailed as
promptly as  practicable  after the Reset Date by the  Corporation to all record
holders of the Series D Preferred  Stock at their last  addresses  as they shall
appear in the stock transfer books of the Corporation.

               (b)  Conversion  Procedures.  Any  holder  of  shares of Series D
Preferred  Stock  desiring  to convert  such  shares  into  Common  Stock  shall
surrender the  certificate or  certificates  evidencing  such shares of Series D
Preferred  Stock at the office of the transfer  agent for the Series D Preferred
Stock,  which certificate or certificates,  if the Corporation shall so require,
shall be duly endorsed to the  Corporation or in blank, or accompanied by proper
instruments  of  transfer  to  the  Corporation  or  in  blank,  accompanied  by
irrevocable written notice to the Corporation that the holder


                                       -6-


<PAGE>

elects so to convert such shares of Series D Preferred  Stock and specifying the
name or names (with address) in which a certificate or  certificates  evidencing
shares of Common Stock are to be issued.  The Corporation need not deem a notice
of conversion to be received  unless the holder complies with all the provisions
hereof.  The  Corporation  will  instruct the  transfer  agent (which may be the
Corporation)  to make a  notation  of the date  that a notice of  conversion  is
received,  which  date shall be deemed to be the date of  receipt  for  purposes
hereof.

         The  Corporation  shall,  as soon as practicable  after such deposit of
certificates  evidencing  shares of Series D Preferred Stock  accompanied by the
written  notice  and  compliance  with any other  conditions  herein  contained,
deliver at such office of such  transfer  agent to the person for whose  account
such shares of Series D Preferred Stock were so  surrendered,  or to the nominee
or nominees of such person, certificates evidencing the number of full shares of
Common Stock to which such person shall be entitled as aforesaid,  together with
a cash adjustment of any fraction of a share as hereinafter provided. Subject to
the following  provisions of this paragraph,  such conversion shall be deemed to
have  been  made as of the date of such  surrender  of the  shares  of  Series D
Preferred Stock to be converted,  and the person or persons  entitled to receive
the Common Stock  deliverable  upon  conversion of such Series D Preferred Stock
shall be treated for all purposes as the record holder or holders of such Common
Stock on such  date;  provided,  however,  that  the  Corporation  shall  not be
required  to convert  any  shares of Series D  Preferred  Stock  while the stock
transfer books of the Corporation are closed for any purpose,  but the surrender
of Series D Preferred  Stock for  conversion  during any period while such books
are so  closed  shall  become  effective  for  conversion  immediately  upon the
reopening  of such books as if the  surrender  had been made on the date of such
reopening,  and the conversion shall be at the conversion rate in effect on such
date.  No  adjustments  in respect of any  dividends on shares  surrendered  for
conversion or any dividend on the Common Stock issued upon  conversion  shall be
made upon the conversion of any shares of Series D Preferred Stock.

         The Corporation shall, at all times following the date which is 90 days
after the Final Closing Date,  reserve and keep  available out of its authorized
but unissued  shares of Common  Stock,  solely for the purpose of effecting  the
conversion of the shares of Series D Preferred  Stock,  such number of shares of
Common Stock as shall from time to time be sufficient  to effect the  conversion
of all outstanding shares of the Series D Preferred Stock.

         In the event that any holder of Preferred  Stock shall  surrender  such
Preferred  Stock for conversion in accordance  with the foregoing  provisions of
this  Section  4(b) and as of the date  such  conversion  is deemed to occur the
Corporation shall have insufficient  authorized,  unissued and unreserved shares
of Common  Stock  remaining  to permit the  issuance  to such holder of the full
number of  shares  of  Common  Stock  otherwise  issuable  upon such  conversion
("Conversion  Shares")  (including,  without limitation,  shares of Common Stock
issuable upon  conversion of the Series D Preferred Stock in the case of a Reset
Event),  the  Corporation  shall instead deliver to such holder a notice that in
the absence of revocation of such conversion as hereinafter provided such holder
shall  receive  upon  conversion  of the Series D Preferred  Stock  tendered for
conversion  (x) a number of Conversion  Shares equal to the remaining  number of
authorized,  unissued and  unreserved  shares of Common Stock and (y) in lieu of
the Conversion Shares in excess of such number (the "Excess Shares"), either (i)
cash in the amount of (A) the Closing Bid Price on the day prior to the date of


                                       -7-


<PAGE>

conversion  multiplied by (B) such number of Excess Shares (the "Cash Equivalent
Conversion  Amount") or (ii) if the Company has no cash or cash  equivalents,  a
secured demand promissory note (each a "Secured Note") of the Corporation in the
principal amount of such Cash Equivalent Conversion Amount bearing interest at a
rate six  percentage  points in excess of the prime  lending rate most  recently
announced by  Citibank,  N.A.  prior to the date of issuance of such  promissory
note (the actual  consideration to be delivered in lieu of such Excess Shares to
be specified in such notice). Such holder shall have until the 20th day from the
date of such notice  (which shall also be the date of its mailing) to revoke the
conversion of such Series D Preferred Stock, or any portion  thereof,  by notice
to the Corporation (it being  understood  that any partial  revocation  shall be
applied  first to the Series D  Preferred  Stock upon  conversion  of which such
Excess Shares would have been issuable).  To the extent the Corporation does not
receive  notice  of  such  revocation  by the  end of such  20-day  period,  the
Corporation  shall  deliver the  consideration  specified  to such holder in the
aforementioned notice within three business days thereafter.

         Except  as set  forth  in  the  preceding  paragraph,  all  notices  of
conversion shall be irrevocable;  provided, however, that if the Corporation has
sent notice of an event  pursuant to Section 4(f)  hereof,  a holder of Series D
Preferred  Stock may, at its election,  provide in its notice of conversion that
the  conversion  of its shares of Series D Preferred  Stock shall be  contingent
upon the  occurrence  of the  record  date or  effectiveness  of such  event (as
specified by such  holder),  provided that such notice of conversion is received
by the Corporation  prior to such record date or effective date, as the case may
be.

         (c) Adjustment of Conversion Rate and Conversion Price.

         (i) Except as otherwise  provided herein,  in the event the Corporation
shall, at any time or from time to time after the date hereof, (1) sell or issue
any shares of Common  Stock for a  consideration  per share less than either (i)
the Conversion  Price in effect on the date of such sale or issuance or (ii) the
Market  Price of the Common  Stock as of the date of the sale or  issuance,  (2)
issue any shares of Common  Stock as a stock  dividend  to the holders of Common
Stock, or (3) subdivide or combine the outstanding shares of Common Stock into a
greater or lesser  number of shares  (any such sale,  issuance,  subdivision  or
combination being herein called a "Change of Shares"), then, and thereafter upon
each further Change of Shares,  the Conversion Price in effect immediately prior
to such  Change of Shares  shall be changed to a price  (rounded  to the nearest
cent) determined by multiplying the Conversion Price in effect immediately prior
thereto by a fraction,  the numerator of which shall be the sum of the number of
shares of Common Stock outstanding  immediately prior to the sale or issuance of
such  additional  shares or such  subdivision or  combination  and the number of
shares of Common Stock which the aggregate consideration received (determined as
provided in  subsection  4(c)(v)(F)  below) for the issuance of such  additional
shares would  purchase at the greater of (i) the  Conversion  Price in effect on
the date of such  issuance  or (ii) the Market  Price as of such  date,  and the
denominator  of which shall be the number of shares of Common Stock  outstanding
immediately  after  the  sale or  issuance  of such  additional  shares  or such
subdivision or combination.  Such adjustment shall be made successively whenever
such an issuance is made.

         (ii) In case of any reclassification,  capital  reorganization or other
change of outstanding shares of Common Stock, or in case of any consolidation or
merger of the Corporation


                                       -8-


<PAGE>

with or into another  corporation (other than a consolidation or merger in which
the  Corporation is the continuing  corporation and which does not result in any
reclassification,  capital  reorganization or other change of outstanding shares
of  Common  Stock  other  than the  number  thereof),  or in case of any sale or
conveyance  to another  corporation  of the property of the  Corporation  as, or
substantially  as, an entirety (other than a  sale/leaseback,  mortgage or other
financing  transaction),  the Corporation shall cause effective  provision to be
made so that  each  holder  of a share of  Series  D  Preferred  Stock  shall be
entitled to receive,  upon conversion of such share of Series D Preferred Stock,
the  kind and  number  of  shares  of stock  or  other  securities  or  property
(including cash) receivable upon such  reclassification,  capital reorganization
or other change,  consolidation,  merger,  sale or conveyance by a holder of the
number of shares of Common  Stock into  which  such share of Series D  Preferred
Stock  was  convertible  immediately  prior  to such  reclassification,  capital
reorganization or other change,  consolidation,  merger, sale or conveyance. Any
such provision shall include  provision for adjustments  that shall be as nearly
equivalent as may be practicable to the adjustments provided for in this Section
4(c). The Corporation  shall not effect any such  consolidation,  merger or sale
unless prior to or  simultaneously  with the consummation  thereof the successor
(if other than the Corporation)  resulting from such  consolidation or merger or
the corporation  purchasing  assets or other  appropriate  corporation or entity
shall assume, by written instrument executed and delivered to the transfer agent
for the Series D Preferred  Stock (the  "Transfer  Agent"),  the  obligation  to
deliver to the holder of each share of Series D  Preferred  Stock such shares of
stock,  securities  or assets as, in accordance  with the foregoing  provisions,
such  holders may be entitled  to receive and the other  obligations  under this
Agreement.   The  foregoing  provisions  shall  similarly  apply  to  successive
reclassifications,  capital  reorganizations  and other  changes of  outstanding
shares  of Common  Stock and to  successive  consolidations,  mergers,  sales or
conveyances.

         (iii) If, at any time or from time to time, the Corporation shall issue
or  distribute  to the  holders  of  shares  of  Common  Stock  evidence  of its
indebtedness,  any other securities of the Corporation or any cash,  property or
other  assets  (excluding  an  issuance or  distribution  governed by one of the
preceding  subsections of this Section 4(c) and also excluding cash dividends or
cash  distributions  paid out of net profits legally  available  therefor in the
full amount thereof (any such non-excluded  event being herein called a "Special
Dividend")), then in each case the holders of the Series D Preferred Stock shall
be entitled to a proportionate share of any such Special Dividend as though they
were the holders of the number of shares of Common Stock of the Corporation into
which their shares of Series D Preferred  Stock are convertible as of the record
date  fixed  for  the  determination  of the  holders  of  Common  Stock  of the
Corporation entitled to receive such Special Dividend.

         (iv) After each  adjustment of the  Conversion  Price  pursuant to this
Section 4(c), the Corporation will promptly prepare a certificate  signed by the
Chairman or  President,  and by the  Treasurer or an Assistant  Treasurer or the
Secretary or an Assistant  Secretary,  of the Corporation setting forth: (i) the
Conversion Price as so adjusted,  (ii) the Conversion Rate corresponding to such
Conversion  and  (iii)  a brief  statement  of the  facts  accounting  for  such
adjustment.  The  Corporation  will  promptly  file  such  certificate  with the
Transfer  Agent and cause a brief summary  thereof to be sent by ordinary  first
class mail to each  registered  holder of Series D  Preferred  Stock at his last
address as it shall  appear on the  registry  books of the  Transfer  Agent.  No
failure to mail such  notice 


                                       -9-


<PAGE>

nor any defect  therein or in the mailing  thereof  shall affect the validity of
such  adjustment.  The  affidavit  of an  officer of the  Transfer  Agent or the
Secretary or an Assistant Secretary of the Corporation that such notice has been
mailed  shall,  in the absence of fraud,  be prima  facie  evidence of the facts
stated  therein.  The  Transfer  Agent  may  rely  on  the  information  in  the
certificate  as true and correct and has no duty or obligation to  independently
verify the amounts or calculations set forth therein.

         (v) For purposes of Section  4(c)(i) hereof,  the following  provisions
(A) to (F) shall also be applicable:

               (A) The number of shares of Common  Stock deemed  outstanding  at
          any given time shall include all shares of capital  stock  convertible
          into or exchangeable  for Common Stock (on an as converted  basis) and
          all  shares  of  Common  Stock  issuable  upon  the  exercise  of  any
          convertible debt, warrants  outstanding on the date hereof and options
          outstanding on the date hereof.

               (B) No  adjustment of the  Conversion  Price shall be made unless
          such adjustment would require an increase or decrease of at least $.01
          in such price;  provided that any adjustments  which by reason of this
          clause (B) are not  required  to be made shall be carried  forward and
          shall be made at the  time of and  together  with the next  subsequent
          adjustment which,  together with any adjustment(s) so carried forward,
          shall  require  an  increase  or  decrease  of at  least  $.01  in the
          Conversion Price then in effect hereunder.

               (C) In case of (1) the sale by the  Corporation  (including  as a
          component  of a unit) of any rights or  warrants to  subscribe  for or
          purchase,  or any options for the  purchase  of,  Common  Stock or any
          securities  convertible  into or  exchangeable  for Common Stock (such
          securities convertible,  exercisable or exchangeable into Common Stock
          being herein called "Convertible Securities"),  or (2) the issuance by
          the  Corporation,  without  the  receipt  by  the  Corporation  of any
          consideration  therefor, of any rights or warrants to subscribe for or
          purchase,  or any  options  for  the  purchase  of,  Common  Stock  or
          Convertible  Securities,  whether  or not  such  rights,  warrants  or
          options,  or  the  right  to  convert  or  exchange  such  Convertible
          Securities,  are immediately  exercisable,  and the  consideration per
          share for which  Common  Stock is issuable  upon the  exercise of such
          rights, warrants or options or upon the conversion or exchange of such
          Convertible   Securities  (determined  by  dividing  (x)  the  minimum
          aggregate  consideration,  as set  forth  in the  instrument  relating
          thereto  without  regard to any  antidilution  or  similar  provisions
          contained therein for a subsequent adjustment of such amount,  payable
          to the  Corporation  upon the  exercise  of such  rights,  warrants or
          options,  plus the  consideration  received by the Corporation for the
          issuance or sale of such  rights,  warrants or options,  plus,  in the
          case of such Convertible Securities,  the minimum aggregate amount, as
          set forth in the  instrument  relating  thereto  without regard to any
          antidilution or similar provisions  contained therein for a subsequent
          adjustment of such amount, of additional consideration,  if any, other
          than such  Convertible  Securities,  payable  upon the  


                                      -10-


<PAGE>

          conversion or exchange  thereof,  by (y) the total maximum number,  as
          set forth in the  instrument  relating  thereto  without regard to any
          antidilution or similar provisions  contained therein for a subsequent
          adjustment of such amount, of shares of Common Stock issuable upon the
          exercise of such rights, warrants or options or upon the conversion or
          exchange of such Convertible  Securities issuable upon the exercise of
          such rights,  warrants or options) is less than either the  Conversion
          Price or the Market  Price of the  Common  Stock as of the date of the
          issuance or sale of such rights,  warrants or options, then such total
          maximum number of shares of Common Stock issuable upon the exercise of
          such rights, warrants or options or upon the conversion or exchange of
          such Convertible Securities (as of the date of the issuance or sale of
          such rights, warrants or options) shall be deemed to be "Common Stock"
          for  purposes  of Section  4(c)(i)  hereof and shall be deemed to have
          been  sold for an  amount  equal to such  consideration  per share and
          shall  cause  an  adjustment  to be made in  accordance  with  Section
          4(c)(i).

               (D) In case of the  sale by the  Corporation  of any  Convertible
          Securities,  whether  or not  the  right  of  conversion  or  exchange
          thereunder  is  immediately  exercisable,  and the price per share for
          which Common Stock is issuable upon the conversion or exchange of such
          Convertible Securities (determined by dividing (x) the total amount of
          consideration  received  by the  Corporation  for  the  sale  of  such
          Convertible  Securities,  plus the minimum  aggregate  amount,  as set
          forth  in  the  instrument  relating  thereto  without  regard  to any
          antidilution or similar provisions  contained therein for a subsequent
          adjustment of such amount, of additional consideration,  if any, other
          than such  Convertible  Securities,  payable  upon the  conversion  or
          exchange thereof, by (y) the total maximum number, as set forth in the
          instrument  relating  thereto  without regard to any  antidilution  or
          similar  provisions  contained therein for a subsequent  adjustment of
          such amount, of shares of Common Stock issuable upon the conversion or
          exchange  of such  Convertible  Securities)  is less than  either  the
          Conversion  Price or the Market  Price of the  Common  Stock as of the
          date of the  sale of such  Convertible  Securities,  then  such  total
          maximum  number of shares of Common Stock issuable upon the conversion
          or exchange of such Convertible Securities (as of the date of the sale
          of such Convertible  Securities)  shall be deemed to be "Common Stock"
          for  purposes  of Section  4(c)(i)  hereof and shall be deemed to have
          been  sold for an  amount  equal to such  consideration  per share and
          shall  cause  an  adjustment  to be made in  accordance  with  Section
          4(c)(i).

               (E)  In  case  the   Corporation   shall  modify  the  rights  of
          conversion,  exchange or exercise of any of the securities referred to
          in (C)  and (D)  above  or any  other  securities  of the  Corporation
          convertible,  exchangeable  or exercisable for shares of Common Stock,
          for any reason other than an event that would  require  adjustment  to
          prevent dilution,  so that the consideration per share received by the
          Corporation after such modification is less than either the Conversion
          Price or the Market  Price as of the date prior to such  modification,
          then  such  securities,  to  the  extent  not  theretofore  exercised,
          converted or exchanged,  shall be deemed to have expired or terminated
          immediately prior to the date of such modification and the 


                                      -11-


<PAGE>

          Corporation   shall  be  deemed  for  purposes  of   calculating   any
          adjustments  pursuant  to this  Section  4(c) to have  issued such new
          securities  upon  such new  terms on the  date of  modification.  Such
          adjustment  shall  become  effective  as of the date upon  which  such
          modification  shall take effect.  On the expiration or cancellation of
          any such right,  warrant or option or the  termination or cancellation
          of any  such  right  to  convert  or  exchange  any  such  Convertible
          Securities,  the  Conversion  Price  then in  effect  hereunder  shall
          forthwith  be  readjusted  to such  Conversion  Price  as  would  have
          obtained  (a) had the  adjustments  made upon the  issuance or sale of
          such rights,  warrants,  options or Convertible  Securities  been made
          upon the basis of the  issuance of only the number of shares of Common
          Stock  theretofore  actually  delivered  (and the total  consideration
          received  therefor)  upon the  exercise  of such  rights,  warrants or
          options  or upon  the  conversion  or  exchange  of  such  Convertible
          Securities  and (b) had  adjustments  been  made on the  basis  of the
          Conversion  Price as adjusted  under  clause (a) for all  transactions
          (which would have affected such adjusted  Conversion Price) made after
          the issuance or sale of such rights, warrants,  options or Convertible
          Securities.

               (F) In case of the  sale  of any  shares  of  Common  Stock,  any
          Convertible  Securities,  any rights or warrants to  subscribe  for or
          purchase,  or any  options  for  the  purchase  of,  Common  Stock  or
          Convertible Securities,  the consideration received by the Corporation
          therefor shall be deemed to be the gross sales price therefor  without
          deducting therefrom any expense paid or incurred by the Corporation or
          any  underwriting  discounts or  commissions  or  concessions  paid or
          allowed by the Corporation in connection therewith.  In the event that
          any securities shall be issued in connection with any other securities
          of the Corporation,  together  comprising one integral  transaction in
          which no specific  consideration  is allocated  among the  securities,
          then each of such  securities  shall be deemed to have been issued for
          such  consideration  as the  Board  of  Directors  of the  Corporation
          determines  in good  faith;  provided,  however  that if holders of in
          excess  of  10% of the  then  outstanding  Series  D  Preferred  Stock
          disagree with such determination, the Corporation shall retain, at its
          own expense, an independent investment banking firm for the purpose of
          obtaining an appraisal.

         (vi)  Notwithstanding  any other provision hereof, no adjustment to the
Conversion Price will be made

               (A) upon the  exercise of any of the options  outstanding  on the
          date hereof under the Corporation's existing stock option plans; or

               (B) upon the issuance or exercise of options  which may hereafter
          be granted with the approval of the Board of Directors,  or exercised,
          under any employee benefit plan of the Company to officers,  directors
          or employees, but only with respect to such options as are exercisable
          at prices no lower  than the  Closing  Bid Price  (or,  if the  prices
          referenced   in  the   definition  of  Closing  Bid  Price  cannot  


                                      -12-


<PAGE>

          be  determined,  the Fair Market  Value) of the Common Stock as of the
          date of grant thereof; or

               (C) upon the sale of any  shares of  Common  Stock,  warrants  to
          purchase  Common Stock or Convertible  Securities in a firm commitment
          underwritten public offering,  including,  without limitation,  shares
          sold upon the  exercise  of any  overallotment  option  granted to the
          underwriters in connection with such offering; or

               (D) upon  issuance  or exercise of the  Placement  Warrants,  the
          Advisory Warrants, the Warrants, the Notes (in each case as defined in
          the Letter  Agreement  between the Corporation and Paramount  Capital,
          Inc. dated as of January 28, 1997 (the "Letter  Agreement")),  or upon
          the issuance or  conversion  of the  Preferred  Stock  included in the
          Premium  Preferred  Units (as defined in the Letter  Agreement) of the
          Corporation  issued (i) on or prior to the Final  Closing Date or (ii)
          pursuant to the exercise or conversion of the Placement Warrants,  the
          Advisory Warrants, the Warrants or the Notes, or

               (E) upon the  issuance  or sale of  Common  Stock or  Convertible
          Securities pursuant to the exercise of any rights, options or warrants
          to receive, subscribe for or purchase, or any options for the purchase
          of,  Common  Stock  or  Convertible  Securities,  whether  or not such
          rights,  warrants  or  options  were  outstanding  on the  date of the
          original  sale of the  Series D  Preferred  Stock  or were  thereafter
          issued or sold,  provided  that an  adjustment  was either made or not
          required to be made in accordance  with Section  4(c)(i) in connection
          with the issuance or sale of such  securities or any  modification  of
          the terms thereof; or

               (F) upon the issuance or sale of Common Stock upon  conversion or
          exchange of any Convertible Securities,  provided that any adjustments
          required  to be made  upon the  issuance  or sale of such  Convertible
          Securities or any  modification of the terms thereof were so made, and
          whether or not such  Convertible  Securities  were  outstanding on the
          date of the  original  sale of the  Series D  Preferred  Stock or were
          thereafter issued or sold.

Section 4(c)(v)(E) shall nevertheless apply to any modification of the rights of
conversion,  exchange or exercise  of any of the  securities  referred to in (A)
through  (C) or, to the  extent  effected  with  respect to less than all of the
outstanding Series D Preferred Stock, as the case may be, (D) above.

         (vii) As used in this Section 4(c),  the term "Common Stock" shall mean
and  include  the  Corporation's  Common  Stock  authorized  on the  date of the
original  issue of the Units and shall also  include  any  capital  stock of any
class of the Corporation  thereafter  authorized which shall not be limited to a
fixed sum or  percentage  in  respect of the  rights of the  holders  thereof to
participate  in dividends and in the  distribution  of assets upon the voluntary
liquidation,  dissolution or winding up of the Corporation;  provided,  however,
that the shares  issuable upon  conversion of the Series D Preferred Stock shall
include only shares of such class designated in the Corporation's 


                                      -13-


<PAGE>

Certificate of  Incorporation  as Common Stock on the date of the original issue
of the Units or (i), in the case of any reclassification, change, consolidation,
merger,  sale or  conveyance of the  character  referred to in Section  4(c)(ii)
hereof, the stock,  securities or property provided for in such section or (ii),
in the case of any  reclassification  or  change  in the  outstanding  shares of
Common  Stock  issuable  upon  conversion  of the Series D Preferred  Stock as a
result of a subdivision  or  combination or consisting of a change in par value,
or from par  value to no par  value,  or from no par  value to par  value,  such
shares of Common Stock as so reclassified or changed.

         (ix) Any  determination  as to whether an adjustment in the  Conversion
Price in effect  hereunder is required  pursuant to Section  4(c),  or as to the
amount of any such adjustment, if required, shall be binding upon the holders of
the Series D Preferred  Stock and the Company if made in good faith by the Board
of Directors of the Company.

         (d) No Fractional  Shares. No fractional  shares or scrip  representing
fractional  shares of Common Stock shall be issued upon  conversion  of Series D
Preferred  Stock.  If more than one  certificate  evidencing  shares of Series D
Preferred  Stock shall be  surrendered  for  conversion  at one time by the same
holder,  the number of full shares  issuable  upon  conversion  thereof shall be
computed  on the basis of the  aggregate  number of shares of Series D Preferred
Stock so  surrendered.  Instead of any  fractional  share of Common  Stock which
would  otherwise be issuable upon conversion of any shares of Series D Preferred
Stock, the Corporation shall pay a cash adjustment in respect of such fractional
interest in an amount  equal to the same  fraction of the Market Price as of the
close of business on the day of conversion.

         (e) Reservation of Shares;  Transfer Taxes;  Etc. The Corporation shall
at all times  reserve and keep  available,  out of its  authorized  and unissued
shares of Common Stock,  solely for the purpose of effecting  the  conversion of
the Series D Preferred Stock,  such number of shares of its Common Stock free of
preemptive  rights as shall be sufficient to effect the conversion of all shares
of Series D Preferred Stock from time to time  outstanding  (including,  without
limitation,  shares of Common Stock  issuable  upon  conversion  of the Series D
Preferred  Stock in the case of a Reset Event).  The  Corporation  shall use its
best  efforts  from time to time,  in  accordance  with the laws of the State of
Delaware,  to increase the authorized number of shares of Common Stock if at any
time the number of shares of authorized,  unissued and  unreserved  Common Stock
shall not be  sufficient to permit the  conversion  of all the  then-outstanding
shares of Series D Preferred Stock.

         The Corporation  shall pay any and all issue or other taxes that may be
payable  in  respect  of any issue or  delivery  of  shares  of Common  Stock on
conversion of the Series D Preferred Stock. The Corporation  shall not, however,
be  required  to pay any tax which may be payable  in  respect  of any  transfer
involved  in the issue or  delivery  of Common  Stock  (or other  securities  or
assets)  in a name  other  than that in which the  shares of Series D  Preferred
Stock so converted were registered,  and no such issue or delivery shall be made
unless and until the person  requesting  such issue has paid to the  Corporation
the  amount  of  such  tax  or  has  established,  to  the  satisfaction  of the
Corporation, that such tax has been paid.


                                      -14-


<PAGE>

         (f) Prior Notice of Certain Events. In case:

               (i) the  Corporation  shall  declare any  dividend  (or any other
          distribution); or

               (ii) the Corporation  shall authorize the granting to the holders
          of Common Stock of rights or warrants to subscribe for or purchase any
          shares of stock of any class or of any other rights or warrants; or

               (iii) of any  reclassification  of  Common  Stock  (other  than a
          subdivision  or  combination  of the  outstanding  Common Stock,  or a
          change in par value, or from par value to no par value, or from no par
          value to par value); or

               (iv)  of  any   consolidation  or  merger   (including,   without
          limitation,  a Merger Transaction) to which the Corporation is a party
          and for which approval of any stockholders of the Corporation shall be
          required,  or of the sale or transfer of all or  substantially  all of
          the assets of the  Corporation  or of any  compulsory  share  exchange
          whereby the Common Stock is converted into other  securities,  cash or
          other property; or

               (v) of the voluntary or involuntary  dissolution,  liquidation or
          winding  up of  the  Corporation  (including,  without  limitation,  a
          Liquidation Event);

then the  Corporation  shall cause to be filed with the  transfer  agent for the
Series D Preferred  Stock, and shall cause to be mailed to the holders of record
of the Series D Preferred  Stock,  at their last  addresses as they shall appear
upon the stock transfer books of the Corporation,  at least 20 days prior to the
applicable record date hereinafter  specified,  a notice stating (x) the date on
which a  record  (if  any) is to be  taken  for the  purpose  of such  dividend,
distribution  or  granting  of rights or  warrants  or, if a record is not to be
taken, the date as of which the holders of Common Stock of record to be entitled
to such  dividend,  distribution,  rights or warrants are to be determined and a
description  of the cash,  securities  or other  property to be received by such
holders upon such  dividend,  distribution  or granting of rights or warrants or
(y) the  date on  which  such  reclassification,  consolidation,  merger,  sale,
transfer,  share  exchange,  dissolution,  liquidation  or  winding  up or other
Liquidation  Event is expected to become  effective,  the date as of which it is
expected  that  holders of Common  Stock of record shall be entitled to exchange
their shares of Common Stock for securities or other property  deliverable  upon
such exchange, dissolution, liquidation or winding up or other Liquidation Event
and the consideration, including securities or other property, to be received by
such holders upon such exchange; provided, however, that no failure to mail such
notice or any defect therein or in the mailing thereof shall affect the validity
of the corporate action required to be specified in such notice.

         (g) Other Changes in Conversion Rate. The Corporation from time to time
may  increase  the  Conversion  Rate by any amount for any period of time if the
period is at least 20 days and if the increase is irrevocable during the period.
Whenever the  Conversion  Rate is so increased,  the  Corporation  shall mail to
holders of record of the Series D  Preferred  Stock a notice of the  increase at
least 15 days before the date the increased  Conversion  Rate takes effect,  and
such notice shall state the increased  Conversion Rate and the period it will be
in effect.


                                      -15-


<PAGE>

         The  Corporation  may make such  increases in the  Conversion  Rate, in
addition to those  required or allowed by this Section 4, as shall be determined
by it, as evidenced by a resolution of the Board of  Directors,  to be advisable
in  order to avoid or  diminish  any  income  tax to  holders  of  Common  Stock
resulting  from any dividend or  distribution  of stock or issuance of rights or
warrants to purchase or  subscribe  for stock or from any event  treated as such
for income tax purposes.

         Notwithstanding  anything to the contrary herein,  in no case shall the
Conversion Price be adjusted to an amount less than $.001 per share, the current
par value of the  Common  Stock  into  which  the  Series D  Preferred  Stock is
convertible.

         (h) Ambiguities/Errors. The Board of Directors of the Corporation shall
have the power to resolve any  ambiguity or correct any error in the  provisions
relating to the  convertibility of the Series D Preferred Stock, and its actions
in so doing shall be final and conclusive.

         5.  Mandatory  Conversion.  At any time on or after the Reset Date, the
Corporation,  at its  option,  may  cause  the  Series D  Preferred  Stock to be
converted  in  whole,  or in part,  on a pro rata  basis,  into  fully  paid and
nonassessable  shares of Common Stock at the then effective  Conversion Rate and
such other  securities and property as herein  provided if the Closing Bid Price
of the Common Stock (or, if the prices  referenced in the  definition of Closing
Bid Price  cannot be  determined,  the Fair Market  Value (as defined in Section
3(b)) of the Common  Stock)  shall  have  exceeded  300% of the then  applicable
Conversion Price for at least 20 trading days in any 30 consecutive  trading day
period  ending 3 days  prior to the date of  conversion.  Any shares of Series D
Preferred Stock so converted shall be treated as having been  surrendered by the
holder  thereof  for  conversion  pursuant  to  Section  4 on the  date  of such
mandatory  conversion (unless previously converted at the option of the holder).
The  Corporation  shall not be entitled to cause any Series D Preferred Stock to
be converted pursuant to this Section 5 if, as a result of such conversion,  the
holder of such Series D Preferred  Stock would be entitled to receive  cash or a
promissory  note of the  Corporation  as provided in Section  4(b). In addition,
notwithstanding  the  foregoing,  the Company  shall not have the right to force
such mandatory  conversion at any time any shares of Series A Preferred Stock of
the Company remain outstanding.

         Not more  than 60 nor less  than 20 days  prior to the date of any such
mandatory  conversion,  notice by first class mail,  postage  prepaid,  shall be
given to the holders of record of the Series D Preferred  Stock to be converted,
addressed to such holders at their last addresses as shown on the stock transfer
books of the  Corporation.  Each such  notice  shall  specify the date fixed for
conversion,  the place or places for  surrender  of shares of Series D Preferred
Stock, and the then effective Conversion Rate pursuant to Section 4.

         Any notice  which is mailed as herein  provided  shall be  conclusively
presumed to have been duly given by the Corporation on the date deposited in the
mail,  whether or not the holder of the Series D Preferred  Stock  receives such
notice;  and failure properly to give such notice by mail, or any defect in such
notice,  to the  holders  of the  shares to be  converted  shall not  affect the
validity of the  proceedings  for the conversion of any other shares of Series D
Preferred  Stock.  On or after the date fixed for  conversion  as stated in such
notice,  each  holder  of shares  called to be  converted  


                                      -16-


<PAGE>

shall surrender the certificate evidencing such shares to the Corporation at the
place  designated  in such  notice  for  conversion.  Notwithstanding  that  the
certificates evidencing any shares properly called for conversion shall not have
been  surrendered,  the  shares  shall no longer be deemed  outstanding  and all
rights  whatsoever  with respect to the shares so called for conversion  (except
the  right of the  holders  to  convert  such  shares  upon  surrender  of their
certificates therefor) shall terminate.

         6. Voting Rights.

         (a) General. Except as otherwise provided herein, in the Certificate of
Incorporation or the By-laws, the holders of shares of Series D Preferred Stock,
the  holders of shares of Common  Stock and the  holders  of any other  class or
series of shares  entitled to vote with the Common Stock shall vote  together as
one class on all matters submitted to a vote of stockholders of the Corporation.
In any such vote,  each share of Series D  Preferred  Stock  shall  entitle  the
holder  thereof to cast the number of votes  equal to the number of votes  which
could be cast in such vote by a holder of the Common Stock into which such share
of Series D Preferred  Stock is convertible on the record date for such vote, or
if no record  date has been  established,  on the date  such vote is taken.  Any
shares  of  Series D  Preferred  Stock  held by the  Corporation  or any  entity
controlled by the Corporation  shall not have voting rights  hereunder and shall
not be counted in determining the presence of a quorum.

         (b) Class Voting  Rights.  In addition to any vote specified in Section
6(a), so long as 50% of the shares of Series D Preferred Stock  (including those
shares of Series D Preferred  Stock issued or issuable  upon the exercise of the
warrants  issued to Paramount  Capital,  Inc., the placement agent in connection
with the offer and sale of the Series D Preferred Stock or any other options for
the purchase of Series D Preferred Stock) shall be outstanding,  the Corporation
shall not,  without the  affirmative  vote or consent of the holders of at least
66.67% of all outstanding Series D Preferred Stock voting separately as a class,
(i) amend, alter or repeal any provision of the Certificate of Incorporation, or
the Bylaws of the  Corporation  so as adversely  to affect the relative  rights,
preferences,  qualifications,  limitations  or  restrictions  of  the  Series  D
Preferred  Stock,   (ii)  approve  the  alteration  or  change  to  the  rights,
preferences  or privileges of the  Preferred  Stock,  (iii) incur or pay off any
indebtedness in excess of $500,000  incurred in the ordinary course of business;
(iv)  authorize  or issue,  or increase the  authorized  amount of, any security
ranking prior to, or on a parity with,  the Series D Preferred  Stock (A) upon a
Liquidation  Event  or (B) with  respect  to the  payment  of any  dividends  or
distributions  or (C) with  respect to voting  rights  (except for class  voting
rights  required  by law);  (v)  approve  the  incorporation  of any  subsidiary
company;  or  (vi)  approve  any  transactions   between  the  Company  and  its
affiliates.  The vote as contemplated  herein shall specifically not be required
for (x) issuances of Common Stock, (y) the  authorization,  issuance or increase
in the amount of the Series D Preferred Stock prior to the Final Closing Date or
(z) any  consolidation  or  merger  of the  Corporation  with  or  into  another
corporation  in which the  Corporation  is not the surviving  entity,  a sale or
transfer  of all or part of the  Corporation's  assets for cash,  securities  or
other property, or a compulsory share exchange.

         7.   Outstanding   Shares.   For  purposes  of  this   Certificate   of
Designations,  a share of Series D Preferred Stock, when issued, shall be deemed
outstanding  except  (i) from the date,  or 


                                      -17-


<PAGE>

the deemed  date,  of surrender of  certificates  evidencing  shares of Series D
Preferred  Stock,  all shares of Series D Preferred  Stock converted into Common
Stock,  (ii) from the date of registration  of transfer,  all shares of Series D
Preferred  Stock  held of record by the  Corporation  or any  subsidiary  of the
Corporation  and (iii) any and all  shares of Series D  Preferred  Stock held in
escrow  prior to  delivery  of such  stock  by the  Corporation  to the  initial
beneficial owners thereof.

         8.  Status of  Acquired  Shares.  Shares of  Series D  Preferred  Stock
received  upon  conversion  pursuant  to  Section 4 or  Section  5 or  otherwise
acquired by the  Corporation  will be restored to the status of  authorized  but
unissued shares of Preferred  Stock,  without  designation as to class,  and may
thereafter be issued, but not as shares of Series D Preferred Stock.

         9. Preemptive  Rights.  The Series D Preferred Stock is not entitled to
any  preemptive  or  subscription  rights in  respect of any  securities  of the
Corporation.

         10. No Amendment or  Impairment.  The  Corporation  shall not amend its
Certificate of Incorporation or participate in any  reorganization,  transfer of
assets, consolidation,  merger, dissolution,  issue or sale of securities or any
other  voluntary  action,  for the  purpose of avoid ing or seeking to avoid the
observance  or  performance  of any of the  terms to be  observed  or  performed
hereunder  by the  Corporation,  but will at all times in good  faith  assist in
carrying out all such action as may be reasonably  necessary or  appropriate  in
order to protect  the rights of the  holders  of the  Series D  Preferred  Stock
against impairment.

         11.  Severability  of  Provisions.  Whenever  possible,  each provision
hereof  shall be  interpreted  in a manner as to be  effective  and valid  under
applicable  law,  but if any  provision  hereof is held to be  prohibited  by or
invalid under  applicable law, such provision  shall be ineffective  only to the
extent of such  prohibition or  invalidity,  without  invalidating  or otherwise
adversely  affecting the remaining  provisions  hereof.  If a court of competent
jurisdiction  should  determine  that a  provision  hereof  would  be  valid  or
enforceable  if a period of time were  extended  or  shortened  or a  particular
percentage were increased or decreased,  then such court may make such change as
shall be necessary to render the provision in question effective and valid under
applicable law.

         12.  Mandatory  Redemption.  If the Company is required to  repurchase,
redeem or otherwise acquire shares of Series A Preferred Stock representing more
than 5% of the aggregate  stated value of the Series A Preferred  Stock then the
Company  shall offer to  repurchase,  redeem or otherwise  acquire the shares of
Series D  Preferred  Stock,  on a pari passu  basis with the Series A  Preferred
Stock  based on the  relative  liquidation  preferences  of each such  series of
Preferred Stock. The Company shall  repurchase,  redeem or otherwise acquire the
shares  of  Preferred  Stock  with the same  consideration  which is paid to the
holders of Series A Preferred Stock.


                                      -18-


<PAGE>


         IN WITNESS WHEREOF, Genta Incorporated,  has caused this certificate to
be signed on its  behalf by Thomas  Adams,  its  President  and Chief  Executive
Officer, this ______ day of ______,1997.


                                   GENTA INCORPORATED




                                   By:_______________________________
                                   Name:  Thomas H. Adams
                                   Title:  President and Chief Executive Officer



ATTEST:



- ------------------------------
Secretary


                                      -19-

                                                                    EXHIBIT 10.1

                       NOTE AND WARRANT PURCHASE AGREEMENT


         PURCHASE  AGREEMENT (this "Agreement") dated as of January 28, 1997, by
and among GENTA INCORPORATED., a Delaware corporation (the "Company"), THE ARIES
FUND, A CAYMAN ISLAND TRUST (the "Trust"),  and THE ARIES DOMESTIC FUND, L.P., a
Delaware limited partnership (the  "Partnership")  (collectively with the Trust,
the "Purchasers").

         The Company  desires to issue and sell to  Purchasers,  and  Purchasers
desire to purchase from the Company,  $3,000,000 aggregate face amount of Senior
Secured Bridge Notes (the "Bridge Notes") in the form attached hereto as Exhibit
A,  7,800,000  Class A Bridge  Warrants (the "Class A Warrants") to purchase one
share of the Common  Stock,  par value  $.001 per  share,  of the  Company  (the
"Common Stock") in the form attached as Exhibit B hereto, and 12,200,000 Class B
Bridge  Warrants to purchase  one share of the Common  Stock of the Company (the
"Class B Warrants",  and collectively with the Class A Warrants, the "Warrants")
in the form  attached  hereto as  Exhibit  C, upon and  subject to the terms and
conditions hereinafter set forth. Accordingly,  in consideration of the premises
and the mutual agreements  contained  herein,  Purchasers and the Company hereby
agree as follows:

         1. Purchase of Company Securities.

         1.1.  Purchase and Sale of the Notes and the  Warrants.  Subject to the
terms and  conditions  set forth herein,  the Company hereby agrees to issue and
sell to Purchasers,  and Purchasers,  severally and not jointly, hereby agree to
purchase from the Company,  the Bridge Notes and the Warrants (allocated amongst
the  Purchasers as set forth on Exhibit D hereof),  at the Closing (as such term
is defined in Section 2.1 hereof).  The aggregate  purchase price for the Bridge
Notes and the Warrants sold pursuant to this Agreement (including any additional
shares of Common Stock  issuable  pursuant to Section  8.6) shall be  $3,000,000
(the "Purchase Price") (allocated amongst the Purchasers as set forth on Exhibit
D hereof).  "Operative Documents" as used herein shall mean this Agreement,  the
Bridge  Notes,  the Warrants,  the Security  Agreement  and the  Certificate  of
Designations for the Series D Preferred Stock.

         2. Closing.

         2.1. Closing.  The closing of the purchase and sale of the Bridge Notes
and the Warrants  will take place at the offices of Paramount  Capital,  Inc. at
787 Seventh Avenue, New York, New York, 10019. Such closing (the "Closing") will
take place at 10:00 A.M.,  local time,  on January 30, 1997;  provided  that the
Closing  may  take  place at such  other  time,  place  or later  date as may be
mutually agreed upon by the Company and  Purchasers.  The date of the Closing is
referred to herein as the  "Closing  Date." At the  Closing,  the  Company  will
deliver to Purchasers  the Bridge Notes and the Warrants  purchased as set forth
in Section 1 hereof,  against  payment of the Purchase Price by  Purchasers,  by
wire transfer payable to the Company. The Bridge Notes and the Warrants shall be
registered in  Purchasers'  name or the name of the  nominee(s) of Purchasers in
such   denominations  as  Purchasers  shall  request  pursuant  to  instructions
delivered to the Company not less than two days prior to the Closing Date.

         3.  Conditions to the  Obligations  of  Purchasers at the Closing.  The
obligation  of  Purchasers  to  purchase  and pay for the  Bridge  Notes and the
Warrants  to be  purchased  by  Purchasers  at the  Closing  is  subject  to the
satisfaction on or prior to the Closing Date of the following conditions,  which
may only be waived by written consent of Purchasers:

         3.1. Opinion of Counsel to the Company.  Purchasers shall have received
from Pillsbury  Madison & Sutro LLP, counsel for the Company,  its opinion dated
the Closing Date in the form of Exhibit D hereto.

         3.2.  Representations  and Warranties.  All of the  representations and
warranties of the Company  contained in this Agreement shall be true and correct
at and as of the  Closing  Date,  except to the extent of changes  caused by the
transactions contemplated hereby.


                                       -1-


<PAGE>

         3.3.  Performance of Covenants.  All of the covenants and agreements of
the Company contained in this Agreement and required to be performed on or prior
to the Closing Date shall have been  performed in a manner  satisfactory  in all
respects to Purchasers.

         3.4. Legal Action. No injunction,  order, investigation,  claim, action
or  proceeding  before  any  court or  governmental  body  shall be  pending  or
threatened  wherein an  unfavorable  judgment,  decree or order would  restrain,
impair or prevent the carrying out of this Agreement or any of the  transactions
contemplated  hereby,  declare  unlawful the  transactions  contemplated by this
Agreement or cause any such transaction to be rescinded.

         3.5.  Consents.  The Company shall have obtained in writing or made all
consents, waivers,  approvals,  orders, permits, licenses and authorizations of,
and registrations,  declarations,  notices to and filings and applications with,
any  governmental  authority or any other person or entity  (including,  without
limitation,  securityholders  and  creditors  of  the  Company)  required  to be
obtained  or made in order to enable the  Company to observe and comply with all
its  obligations  under  this  Agreement  and  to  consummate  the  transactions
contemplated hereby.

         3.6. Closing Documents.  The Company shall have delivered to Purchasers
the following:

         (a) a certificate  executed by the President or Chief Executive Officer
of the Company dated the Closing Date stating that the  conditions  set forth in
Sections 3.2 through 3.5 have been satisfied;

         (b) an incumbency  certificate  dated the Closing Date for the officers
of the Company  executing this Agreement,  the Bridge Notes and the Warrants and
any other  documents or instruments  delivered in connection with this Agreement
at the Closing;

         (c) a  certificate  of the  Secretary  or  Assistant  Secretary  of the
Company,  dated the Closing Date, as to the continued and valid existence of the
Company,  certifying  the  attached  copy of the  By-laws  of the  Company,  the
authorization of the execution,  delivery and performance of this Agreement, and
the resolutions adopted by the Board of Directors of the Company authorizing the
actions to be taken by the Company under this Agreement;

         (d) a  certificate  of the Secretary of State of the State of Delaware,
dated a recent date,  to the effect that the Company is in good  standing in the
State of  Delaware  and that all  annual  reports,  if any,  have been  filed as
required and that all taxes and fees have been paid in connection therewith;

         (e) a certified copy of the Certificate of Incorporation of the Company
as filed with the Secretary of State of the State of Delaware and any amendments
thereto; and

         (f) such  certificates,  other  documents and instruments as Purchasers
and their counsel may reasonably  request in connection with, and to effect, the
transactions contemplated by this Agreement.

         3.7.  Proceedings.  All corporate and other  proceedings taken or to be
taken in connection with the transactions  contemplated hereby to be consummated
at the Closing and all documents  incident thereto shall be satisfactory in form
and substance to Purchasers.

         3.8. Due  Diligence.  Prior to the Closing Date,  Purchasers  and their
counsel shall have  completed  their due  diligence  and business  review of the
Company,  its  business,  assets,  liabilities,  corporate  and legal status and
intellectual property,  including patents, licenses and technical processes, all
of which shall be satisfactory in form and substance to each Purchaser and their
counsel in each Purchaser's sole discretion.

         3.9. Closing Financial Statements;  Absence of Changes. (a) The Company
shall have provided to Purchasers (i) the unaudited balance sheet of the Company
as of September 30, 1996, and the related unaudited  statement of operations for
the  three-month  (and  nine-month)  periods then ended,  as well as the related
unaudited  statements of  stockholders'  equity (deficit) and cash flows for the
nine-month  period  then ended,  accompanied  by the  unqualified  certification
thereon of the Chief Financial Officer or Vice President--Finance of the Company
(together with any notes thereto, the "September 30


                                       -2-

<PAGE>

Financial  Statements")  and  (ii)  a  "bring-down"  certificate  of  the  Chief
Executive  Officer  of the  Company  and the  Chief  Financial  Officer  or Vice
President--Finance  of the Company with respect to the financial position of the
Company as of the Closing Date and as to results for the period from the date of
the September 30 Financial Statements to the Closing Date, in form and substance
satisfactory to Purchaser and its counsel.

         (b)  Except  as  set  forth  on the  schedules  hereto  of the  Company
delivered to Purchaser as of the date hereof,  there shall have been no material
adverse  change in the  financial  condition,  operating  results,  employee  or
customer  relations or prospects  of, or otherwise  with respect to, the Company
from the date of the September 30 Financial Statements to the Closing Date.

         3.10.  Security  Agreement.  The  Company  shall  have  entered  into a
security agreement (the "Security  Agreement") with Paramount Capital,  Inc., as
collateral  agent,  reasonably  acceptable  to the  Partnership  and  the  Trust
pursuant  to which the Company  shall  grant the  holders of the Bridge  Notes a
first  lien  security  interest  in all of the assets of the  Company  which the
Company is not otherwise  restricted from granting such a security  interest and
the  Company  shall have taken all steps  necessary  to  perfect  such  security
interest.

         3.11. Schedules.  The Company shall have provided to the Purchasers all
schedules  required  pursuant  to  this  Agreement,  which  schedules  shall  be
satisfactory to Purchasers in their sole discretion.

         4.  Conditions to the  Obligations  of the Company at the Closing.  The
obligation  of the  Company  to issue  and sell the Notes  and the  Warrants  to
Purchasers  at the  Closing is subject  to the  satisfaction  on or prior to the
Closing  Date of the  following  conditions,  any of which  may be waived by the
Company:

         4.1. Representations and Warranties. The representations and warranties
of Purchasers contained in this Agreement shall be true and correct at and as of
the Closing Date.

         4.2. Legal Action. No injunction,  order, investigation,  claim, action
or  proceeding  before  any  court or  governmental  body  shall be  pending  or
threatened  wherein an  unfavorable  judgment,  decree or order would  restrain,
impair or prevent the carrying out of this Agreement or any of the  transactions
contemplated  hereby,  declare  unlawful the  transactions  contemplated by this
Agreement or cause any such transaction to be rescinded.

         5.  Representations  and Warranties of the Company.  The Company hereby
represents and warrants to Purchasers as follows:

         5.1. Organization. The Company is a corporation duly organized, validly
existing  and in good  standing  under  the laws of the State of  Delaware.  The
Company has all requisite corporate power and authority, and holds all licenses,
permits  and  other  required  authorizations  from  governmental   authorities,
necessary to conduct its business as it is now being conducted or proposed to be
conducted  and to own or lease the  properties  and  assets it now owns or holds
under  lease  (except  that the  Company may in the future be required to obtain
certain  approvals of the U.S. Food and Drug  Administration  in connection with
its  business as proposed to be  conducted).  The Company is duly  qualified  or
licensed  and in good  standing as a foreign  corporation  in each  jurisdiction
wherein  the  character  of its  properties  or  the  nature  of the  activities
conducted by it makes such qualification or licensing necessary.

         5.2.  Charter  Documents.  The  Company  has  heretofore  delivered  to
Purchasers  true,  correct and complete  copies of the Company's  Certificate of
Incorporation and By-Laws as in full force and effect on the date hereof.

         5.3.  Capitalization.  As of the date hereof, the Company's  authorized
capitalization  consists  of:  150,000,000  shares  of  Common  Stock,  of which
39,991,626  shares are presently  issued and  outstanding;  5,000,000  shares of
preferred  stock,  par value  $.001  per  share,  of which  600,000  shares  are
designated as Series A Convertible  Preferred Stock (528,100 of which are issued
and  outstanding),  3,000 of  which  are  designated  as  Series  B  Convertible
Preferred Stock (none of which are issued and outstanding) and 7100 of which are
designated as Series C Convertible Preferred Stock (1424 of which are issued and
outstanding)  and  20,000  of which  are  designated  as  Series  F  Convertible
Preferred  Stock  (none of which are issued  and  outstanding);  and  18,423,610
shares of Common Stock are


                                       -3-


<PAGE>

reserved for issuance upon the  conversion or exercise of presently  outstanding
convertible  securities,  options,  warrants or other rights to purchase  Common
Stock. All outstanding  securities of the Company are validly issued, fully paid
and  nonassessable.  No stockholder of the Company is entitled to any preemptive
rights with  respect to the purchase or sale of any  securities  by the Company.
Except as has been set forth in Schedule  5.3 hereto,  there are no  outstanding
options, warrants or other rights, commitments or arrangements, written or oral,
to purchase or otherwise  acquire any authorized but unissued  shares of capital
stock of the Company or any security directly or indirectly  convertible into or
exchangeable  for any  capital  stock of the  Company  or under  which  any such
option,  warrant or convertible  security may be issued in the future, and there
are no voting trusts or agreements, stockholders' agreements, pledge agreements,
buy-sell,  rights of first offer,  negotiation  or refusal or proxies or similar
arrangements relating to any securities of the Company to which the Company is a
party,  and to the best knowledge of the Company after due  investigation  there
are no such trusts,  agreement,  rights,  proxies or similar  arrangements as to
which the  Company is not a party.  Except as set forth on  Schedule  5.3 and as
contemplated  herein,  none of the  shares of  capital  stock of the  Company is
reserved for any purpose,  and the Company is neither  subject to any obligation
(contingent or otherwise), nor has any option to repurchase or otherwise acquire
or retire  any  shares of its  capital  stock.  Schedule  5.3 sets forth (i) the
number of shares of Common Stock  authorized  for issuance  under the  Company's
1991 Stock Option Plan, as amended and restated, and the Company's Non- Employee
Director  Stock  Option  Plan;  (ii) the number of shares of Common  Stock as to
which  options  under  such plan have been (a)  reserved  for  issuance  and (b)
exercised;  and (iii) the exercise prices for all outstanding options under such
plan.  Except as set forth on Schedule  5.3, no  antidilution  adjustments  with
respect to the  outstanding  securities  of the Company will be triggered by the
issuance of the securities contemplated hereby.

         5.4 Due Authorization,  Valid Issuance,  Etc.. The Notes have been duly
authorized  and, when issued in accordance  with this Agreement upon the Closing
Date, will be free and clear of all liens imposed by or through the Company. The
Warrants have been duly  authorized  and,  when issued in  accordance  with this
Agreement  upon the Closing Date,  will be validly  issued and free and clear of
all liens imposed by or through the Company.  The Common Stock issuable upon the
exercise of the Warrants have been duly  authorized  and reserved,  and upon the
exercise of the Warrants in accordance with the terms and conditions thereof and
this Agreement,  will be validly issued,  fully paid and nonassessable shares of
Common  Stock and will be free and clear of all liens  imposed by or through the
Company.  The issuance,  sale and clear delivery of the Notes,  the Warrants and
the Common Stock  issuable upon the exercise of the Warrants will not be subject
to any preemptive  right of stockholders of the Company or to any right of first
refusal or other right in favor of any person.

         5.5.  Subsidiaries.  The  Company  has no  wholly  or  partially  owned
Subsidiaries  (as  defined in Section  9.10) and does not  control,  directly or
indirectly,   any  other  corporation,   business  trust,   firm,   partnership,
association, joint venture, entity or organization. The Company does not own any
shares of stock,  partnership  interest,  joint  venture  interest  or any other
security,  equity or interest in any other corporation or other  organization or
entity.

         5.6. Authorization; No Breach. The Company has the full corporate power
and authority to execute,  deliver and enter into this  Agreement and to perform
its obligations hereunder,  and the execution,  delivery and performance of this
Agreement,  the Notes,  the  Warrants,  the Security  Agreement  and any related
financing   statement  and  the  Certificate  of  Designations   and  all  other
transactions  contemplated hereby have been duly authorized by the Company,  and
this Agreement constitutes a legal, valid and binding obligation of the Company,
enforceable in accordance with its terms except as the enforceability hereof may
be limited by (a) bankruptcy,  insolvency, moratorium and similar laws affecting
creditors'  rights  generally and (b) the availability of remedies under general
equitable  principles  and  (c) to the  extent  the  indemnification  provisions
contained  in section 8.5 hereof may be limited by  applicable  federal or state
securities laws.  Except as set forth on Schedule 5.6 hereto,  the execution and
delivery by the Company of this  Agreement,  the offering,  sale and issuance of
the Notes and the Warrants  pursuant to this Agreement,  and the performance and
fulfillment of the Company of its obligations  under this  Agreement,  the Notes
and the Warrants, do not and will not (i) conflict with or result in a breach of
the terms,  conditions or provisions  of, (ii)  constitute a default  under,  or
event which,  with notice or lapse of time or both, would constitute a breach of
or default under, (iii) result in the creation of any lien, security
interest,  adverse claim, charge or encumbrance upon the capital stock or assets
of the Company  pursuant  to, (iv) give any 


                                       -4-


<PAGE>

third party the right to  accelerate  any  obligation  under or  terminate,  (v)
result in a violation  of, (vi) result in the loss of any license,  certificate,
legal  privilege or legal right  enjoyed or possessed by the Company  under,  or
(vii) require any authorization, consent, approval, exemption or other action by
or notice to any court or  administrative  or  governmental  body pursuant to or
require the consent of any other person under,  the Certificate of Incorporation
or By-Laws of the Company or any law,  statute,  rule or regulation to which the
Company  is  subject  or by  which  any  of its  properties  are  bound,  or any
agreement, instrument, order, judgment or decree to which the Company is subject
or by which its properties are bound.

         5.7.  Financial  Statements and SEC Documents.  (a) Attached  hereto as
Schedule  5.7 are (i) the audited  financial  statements  of the Company for the
fiscal year ended  December 31, 1995,  including the balance sheet as at the end
of such fiscal  year and the related  statements  of  operations,  stockholders'
equity (deficit) and cash flows for such fiscal year, certified by Ernst & Young
L.L.P. and (ii) the September 30 Financial  Statements (the financial statements
referred to in clauses (i) and (ii) are referred to herein  collectively  as the
"Financial  Statements").  For purposes of this  Agreement,  September 30. 1996,
shall be  hereinafter  referred to as the "Balance  Sheet  Date." The  Financial
Statements  have been prepared in  accordance  with the books and records of the
Company and generally accepted accounting principles,  applied consistently with
the past practices of the Company  (except as otherwise  noted in such Financial
Statements), reflect all liabilities and obligations of the Company, as of their
respective  dates, and present fairly the financial  position of the Company and
the  results  of its  operations  as of the time and for the  periods  indicated
therein.

(b) The Company has made  available to  Purchasers  a true and complete  copy of
each report,  schedule,  registration  statement and definitive  proxy statement
filed by the Company with the Securities and Exchange  Commission  since January
1, 1993 (as such documents have since the time of their filing been amended, the
"SEC Documents")  which are all the documents (other than preliminary  material)
that  the  Company  was  required  to file  with  the  Securities  and  Exchange
Commission  since such date.  As of their  respective  dates,  the SEC Documents
complied in all respects with the requirements of the Securities Act (as defined
in Section  9.7) and/or the Exchange Act (as defined in Section 9.8) as the case
may be, and the rules and regulations of the Securities and Exchange  Commission
thereunder  applicable  to such  SEC  Documents  and  none of the SEC  Documents
contained  any untrue  statement  of a material  fact or omitted to statement of
material fact required to be stated  therein or necessary to make the statements
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading.  The  financial  statements  of the  Company  included  in  the  SEC
Documents comply as to form in all material respects with applicable  accounting
requirements  and with the published rules and regulations of the Securities and
Exchange Commission with respect thereto,  have been prepared in accordance with
generally  accepted  accounting  principles applied on a consistent basis during
the periods involved (except as may be indicated in the notes thereto or, in the
case of the unaudited  statements,  as permitted by Form 10-Q of the  Securities
and  Exchange  Commission)  and  fairly  present  (subject,  in the  case of the
unaudited  statements,  to normal,  recurring audit  adjustments)  the financial
position of the Company as at the dates thereof and the consolidated  results of
their operations and cash flows for the periods then ended.

         5.8. No Material Adverse  Changes.  Except as set forth on Schedule 5.8
hereto,  since the  Balance  Sheet  Date  there has not at any time been (a) any
material adverse change in the financial condition,  operating results, business
prospects, employee relations or customer relations of the Company, or (b) other
adverse  changes,  which in the aggregate  have been  materially  adverse to the
Company.

         5.9.  Absence of Certain  Developments.  Except as contemplated by this
Agreement,  and except as set forth in Schedule  5.9  hereto,  since the Balance
Sheet Date, the Company has not, nor will have prior to the Closing:  (a) issued
any  securities;  (b) borrowed  any amount or incurred or became  subject to any
liabilities  (absolute or contingent),  other than  liabilities  incurred in the
ordinary course of business and liabilities  under contracts entered into in the
ordinary  course of  business,  none of which are or shall be material and which
are less than $75,000;  (c)  discharged or satisfied any lien,  adverse claim or
encumbrance or paid any obligation or liability (absolute or contingent),  other
than current  liabilities paid in the ordinary course of business;  (d) declared
or  made  any  payment  or  distribution  of  cash  or  other  property  to  the
stockholders  of the Company  with  respect to the Common  Stock or purchased or
redeemed any shares of Common Stock; (e) mortgaged,  pledged or subjected to any
lien, adverse claim,  charge or any other encumbrance,  any of its properties or
assets,  except for liens for taxes not yet 


                                       -5-


<PAGE>

due and payable;  (f) sold, assigned or transferred any of its assets,  tangible
or intangible,  except in the ordinary  course of business and in an amount less
than  $75,000,  or  disclosed  to any  person,  firm or  entity  not  party to a
confidentiality   agreement  with  the  Company  any  proprietary   confidential
information;  (g)  suffered  any  extraordinary  losses or waived  any rights of
material value; (h) made any capital expenditures or commitments  therefor;  (i)
entered into any other transaction other than in the ordinary course of business
in an amount less than $75,000 or entered into any material transaction, whether
or not in the ordinary course of business; (j) made any charitable contributions
or pledges;  (k) suffered damages,  destruction or casualty loss, whether or not
covered by insurance,  affecting any of the  properties or assets of the Company
or any other  properties  or assets of the  Company  which could have a material
adverse effect on the business or operations of the Company; (l) made any change
in the nature or operations  of the business of the Company;  or (m) resolved or
entered  into  any  agreement  or  understanding  with  respect  to  any  of the
foregoing.

         5.10.  Properties.  The Company has good and marketable title to all of
the real  property and good title to all of the personal  property and assets it
purports to own, including those reflected as owned on the Company Balance Sheet
or acquired thereafter,  and a good and valid leasehold interest in all property
indicated as leased on the Company Balance Sheet,  whether such property is real
or personal, free and clear of all liens, adverse claims, charges,  encumbrances
or  restrictions of any nature  whatsoever,  except (a) such as are reflected on
the Company  Balance  Sheet or  described  in  Schedule  5.10 hereto and (b) for
receivables and charges collected in the ordinary course of business.  Except as
disclosed  in  Schedule  5.10  hereto,  the  Company  owns or  leases  all  such
properties as are necessary to its  operations as now conducted and as presently
proposed to be conducted and all such properties are, in all material  respects,
in good operating condition and repair.

         5.11. Taxes. Except as referred to in Schedule 5.11 hereto, the Company
has timely filed all federal,  state,  local and foreign tax returns and reports
required to be filed, and all taxes, fees,  assessments and governmental charges
of any nature  shown by such returns and reports to be due and payable have been
timely paid except for those amounts being contested in good faith and for which
appropriate  amounts have been reserved in accordance  with  generally  accepted
accounting  principles and are reflected on the Company Balance Sheet.  There is
no tax deficiency  which has been, or, to the knowledge of the Company might be,
asserted  against  the  Company  which would  adversely  affect the  business or
operations,  or proposed  business or operations,  of the Company.  All such tax
returns and reports were  prepared in  accordance  with the  relevant  rules and
regulations of each taxing  authority having  jurisdiction  over the Company and
are true and correct.  The Company has neither given nor been  requested to give
any waiver of any  statute of  limitations  relating  to the payment of federal,
state,  local or foreign  taxes.  The Company has not been, nor is it now being,
audited by any federal, state, local or foreign tax authorities. The Company has
made all required  deposits for taxes  applicable  to the current tax year.  The
Company is not, and has never been, a member of any  "affiliated  group"  within
the meaning of Section 1504 of the Internal Revenue Code, as in effect from time
to time.

         5.12.  Litigation.  Except as set forth on Schedule 5.12 hereto,  there
are no actions, suits, proceedings, orders, investigations or claims pending or,
to the Company's knowledge,  threatened against or affecting the Company, at law
or in equity or before or by any federal, state, municipal or other governmental
department,  commission, board, bureau, agency or instrumentality;  there are no
arbitration  proceedings  pending  under  collective  bargaining  agreements  or
otherwise;  and, to the  knowledge of the Company,  there is no basis for any of
the foregoing.

         5.13.  Compliance  with Law.  The Company has  complied in all respects
with all  applicable  statutes and  regulations  of the United States and of all
states,  municipalities  and applicable  agencies and foreign  jurisdictions  or
bodies in  respect  of the  conduct  of its  business  and  operations,  and the
failure,  if any, by the Company to have fully complied with any such statute or
regulation  does not and will not  materially  adversely  affect the business or
operations of the Company.

         5.14.  Trademarks and Patents.  Schedule 5.14 annexed hereto contains a
true,  complete and correct  list of all  trademarks,  trade names,  patents and
copyrights (and applications  therefor) if any, heretofore or presently owned or
licensed or used or required  to be used by the Company in  connection  with its
business; and, except as set forth on Schedule 5.14, each such trademark,  trade
name, patent and copyright (and 


                                       -6-


<PAGE>

application  therefor)  listed in Schedule 5.14 as being owned by the Company is
not subject to any license,  royalty arrangement,  option or dispute and is free
and  clear of all  liens.  To the best  knowledge  of the  Company,  none of the
trademarks, trade names, patents or copyrights used by the Company in connection
with its business  infringe any  trademark,  trade name,  patent or copyright of
others in the United States or in any other country,  in any way which adversely
affects or which in the future may  adversely  affect the business or operations
of the Company. Except as set forth in Schedule 5.14, no stockholder, officer or
director  of the  Company or any other  person  owns or has any  interest in any
trademark,  trade name, service mark, patent, copyright or application therefor,
or trade  secret,  licenses,  invention,  information  or  proprietary  right or
process,  if any,  used by the  Company in  connection  with its  business.  The
Company has no notice or knowledge of any  objection or claim being  asserted by
any person with respect to the ownership,  validity enforceability or use of any
such trademarks, trade names, patents and copyrights (and applications therefor)
listed  on  Schedule  5.14  or  challenging  or  questioning   the  validity  or
effectiveness of any license relating thereto. There are no unresolved conflicts
with,  or  pending  claims  of,  any other  person,  whether  in  litigation  or
otherwise,  involving the trademarks,  trade names,  patents and copyrights (and
applications therefor), and there are no liens, encumbrances, adverse claims, or
rights of any other person which would prevent the Company form  fulfilling  its
obligations  under this  Agreement.  To the best  knowledge of the Company,  the
business of the Company,  as presently conducted and as proposed to be conducted
does not and will not cause the  Company to violate any  trademark,  trade name,
patent,  copyright,  trade secret,  license or proprietary interest of any other
person or entity,  in any way which adversely affects or which in the future may
adversely affect the business or operations of the Company.  Except as disclosed
in Schedule  5.14  hereto,  the Company  possesses  all  proprietary  technology
necessary  for the  conduct  of  business  by the  Company,  both  as  presently
conducted and as presently proposed to be conducted.

         5.15.  Insurance.   Schedule  5.15  annexed  hereto  contains  a  brief
description of each insurance  policy  maintained by the Company with respect to
its  properties,  assets  and  business;  each such  policy is in full force and
effect;  and the Company is not in default with respect to its obligations under
any of such  insurance  policies.  The  insurance  coverage of the Company is in
amounts not less than is customarily  maintained by corporations  engaged in the
same or similar business and similarly situated,  including, without limitation,
insurance against loss, damage,  fire, theft,  public liability and other risks.
The  activities and operations of the Company have been conducted in a manner so
as to conform to all applicable  provisions of these insurance  policies and the
Company  has not taken or failed to take any action  which  would cause any such
insurance policy to lapse.

         5.16.  Agreements.  Except as set forth in Schedule  5.16  hereto,  the
Company is neither a party to nor bound by any agreement or commitment,  written
or oral,  which  obligates the Company to make payments to any person,  or which
obligates any person to make  payments to the Company,  in the case of each such
agreement in an amount exceeding $75,000,  or which is otherwise material to the
conduct and operation of the Company's  business or proposed  business or any of
its  properties  or assets,  including,  without  limitation,  all  shareholder,
employment, non-competition and consulting agreements and employee benefit plans
and arrangements and collective  bargaining agreements to which the Company is a
party or by which it is bound. All such agreements are legal,  valid and binding
obligations  of the  Company,  in full  force and  effect,  and  enforceable  in
accordance with their respective terms, except as the enforceability thereof may
be limited by (a) bankruptcy, insolvency, moratorium, and similar laws affecting
creditors'  rights  generally and (b) the availability of remedies under general
equitable  principles.  The Company has performed all obligations required to be
performed  by it, and is not in default,  or in receipt of any claim,  under any
such  agreement or  commitment,  and the Company has no present  expectation  or
intention of not fully performing all of such obligations,  nor does the Company
have any knowledge of any breach or  anticipated  breach by the other parties to
any such  agreement or  commitment.  The Company is not a party to any contract,
agreement,  instrument or understanding  which materially  adversely affects the
business,  properties,  operations, assets or condition (financial or otherwise)
of the Company.  Purchasers  have been  furnished  with, or the Company has made
available for the  Purchaser's  review,  a true and correct copy of each written
agreement referred to in Schedule 5.16, together with all amendments, waivers or
other changes thereto.

         5.17.  Undisclosed  Liabilities.  Except as set forth on Schedule  5.17
hereto, the Company has no obligation or liability  (whether accrued,  absolute,
contingent,  unliquidated,  or  otherwise,  whether or not known to the Company,
whether due or to become 


                                       -7-


<PAGE>

due) arising out of transactions entered into at or prior to the Closing of this
Agreement,  or any  action  or  inaction  at or  prior  to the  Closing  of this
Agreement,  or any state of facts  existing  at or prior to the  Closing of this
Agreement,  except (a) liabilities  reflected on the Company Balance Sheet;  (b)
liabilities  in an amount less than $75,000  incurred in the ordinary  course of
business  since the Balance  Sheet Date (none of which is a liability for breach
of contract, breach of warranty, torts, infringements,  claims or lawsuits); and
(c) liabilities or obligations disclosed in the schedules hereto.

         5.18. Employees;  Conflicting  Agreements.  (a) The Company shall cause
all members of management and all professional  employees of and consultants and
advisors to the Company,  including all employees and  consultants  and advisors
involved in its  research  and  development,  to be subject to  agreements  with
respect to (i)  nondisclosure  of confidential  information,  (ii) assignment of
patents, trademarks,  copyrights and proprietary rights to the Company and (iii)
disclosure to the Company of inventions.

         (b) Except as set forth on Schedule  5.18, to the best of the Company's
knowledge, no stockholder, director, officer or key employee of the Company is a
party to or bound by any agreement,  contract or  commitment,  or subject to any
restrictions in connection  with any previous or current  employment of any such
person,  which adversely  affects,  or which in the future may adversely affect,
the business or the proposed business of the Company or the rights of Purchasers
under this  Agreement  and in respect of its rights as a holder of the Notes and
the Warrants.

         5.19.  Disclosure.  Neither this  Agreement  nor any of the  schedules,
exhibits, written statements,  documents or certificates prepared or supplied by
the Company with respect to the  transactions  contemplated  hereby  contain any
untrue  statement of a material fact or omit a material  fact  necessary to make
the  statements  contained  herein or  therein  not  misleading  in light of the
circumstances  under which made.  Except as disclosed  in Schedule  5.19 hereto,
there exists no fact or circumstance which, to the knowledge of the Company upon
due  inquiry,  materially  adversely  affects,  or  which  could  reasonably  be
anticipated  to have a material  adverse  effect on, the  existing  or  expected
financial condition,  operating results,  assets,  customer relations,  employee
relations or business prospects of the Company.

         5.20.  Compliance  with the  Securities  Laws.  Except  as set forth on
Schedule  5.20 hereto,  neither the Company nor anyone  acting on its behalf has
directly or indirectly offered the Notes and the Warrants or any part thereof or
any similar  security of the Company  (or any other  securities  convertible  or
exchangeable for the Notes and the Warrants or any similar  security),  for sale
to, or solicited any offer to buy the same from,  anyone other than  Purchasers.
Assuming the accuracy and truth of each of the Purchasers'  representations  set
forth in Section 6 of this Agreement,  all securities of the Company  heretofore
sold and issued by it were sold and issued,  and the Notes and the Warrants were
offered and will be sold and issued,  in compliance with all applicable  federal
and state securities laws.

         5.21. Brokers. Except as set forth on Schedule 5.21, no finder, broker,
agent, financial person or other intermediary has acted on behalf of the Company
in  connection  with  the  offering  of  the  Notes  and  the  Warrants  or  the
consummation of this Agreement or any of the transactions contemplated hereby.

         5.22.  Transactions  with  Affiliates.  Except as set forth in Schedule
5.22, no director,  officer,  employee,  consultant or agent of the Company,  or
member of the family of any such person or any corporation,  partnership,  trust
or other  entity in which any such  person,  or any  member of the family of any
such person, has a substantial interest in or is an officer, director,  trustee,
partner or holder of more than 5% of the outstanding capital stock thereof, is a
party to any transaction with the Company, including any contract,  agreement or
other arrangement  providing for the employment of, furnishing of services by or
requiring payments to any such person or firm.

         5.23.  Environmental  Matters (a) The Company and all properties owned,
operated or leased by the Company  have  obtained  and  currently  maintain  all
environmental  permits  required for their  business and  operations  and are in
compliance  with  all  such  environmental  permits;  (ii)  there  are no  legal
proceedings  pending nor, to the best  knowledge of the Company,  threatened  to
modify or revoke any such environmental  permits;  and (iii) neither Company nor
any  property  owned,  operated or leased by the Company has received any notice
from any source that there is lacking any environmental  permit 


                                       -8-


<PAGE>

required for the current use or operation of the business of the Company, or any
property owned, operated or leased by the Company.

         (b) Except as set forth in Schedule 5.23 hereto,  (i) all real property
owned,  operated or leased by the  Company,  and, to the best  knowledge  of the
Company,  all property adjacent to such properties,  are free from contamination
by any hazardous material; and the Company is not subject to environmental costs
and  liabilities  with  respect  to  hazardous   materials,   and  no  facts  or
circumstances exist which could give rise to environmental costs and liabilities
with respect to hazardous materials.

         (c) Except as set forth in Schedule 5.23 hereto,  there is not now, nor
has there been in the past, on, in, or under any real property owned, leased, or
operated   by  the   Company,   or  by  any  of   its   predecessors   (i)   any
asbestos-containing   materials,  (ii)  any  underground  storage  tanks,  (iii)
above-ground storage tanks, (iv) impoundments,  (v) poly- chlorinated  biphenyls
or (vi) radioactive substances.

         (d) The Company  has  provided or made  available  to Buyer  drafts and
final versions of all environmental site assessments (including, but not limited
to  Phase  I and  Phase  II  reports),  risk  management  studies  and  internal
environmental  audits  that have been  conducted  by or on behalf of the Company
("Environmental  Studies"), with respect to any real property that now or in the
past  has  been  owned,  operated  or  leased  by  the  Company,  or  any of its
predecessors.

         (e) Except as set forth in Schedule  5.23  hereto,  the Company and all
properties  owned,  operated  or leased by the Company  are in  compliance  with
environmental law.

         (f) Except as set forth in Schedule  5.23  hereto,  neither the Company
nor any property  owned,  leased or operated by the Company has received or been
issued any written  request for  information,  or has been notified that it is a
potentially  responsible party under the environmental  laws with respect to any
on-site or off-site for which environmental costs and liabilities are asserted.

         6.  Representations  and  Warranties of Purchasers.  Purchasers  hereby
severally represent and warrant to the Company as follows:

         6.1.  Investment  Intent.  Each  of the  Purchasers  is an  "accredited
investor"  within the meaning of Regulation D under the Securities  Act. Each of
the  Purchasers  has  experience  in making  investments  in  development  stage
biotechnology  companies and is acquiring the Notes and the Warrants for its own
account  and not with a present  view to, or for sale in  connection  with,  any
distribution  thereof  in  violation  of the  registration  requirements  of the
Securities  Act.   Purchasers  consent  to  the  placing  of  a  legend  on  the
certificates  representing  the Notes and the  Warrants  to the effect  that the
shares of Common Stock issuable upon exercise or conversion, as the case may be,
of the  Warrants,  and the Purchase  Option have not been  registered  under the
Securities Act and may not be transferred  except in accordance  with applicable
securities laws or an exception therefrom.

         6.2.  Authorization.  Each of Purchasers has the power and authority to
execute and deliver this  Agreement  and to perform its  obligations  hereunder,
having obtained all required consents, if any, and this Agreement, when executed
and  delivered,  will  constitute a legal valid and binding  obligation  of such
Purchaser.

         6.3.  Brokers.  No finder,  broker,  agent,  financial  person or other
intermediary  has acted on behalf of Purchasers in connection  with the offering
of the Notes and the Warrants or the  consummation  of this  Agreement or any of
the transactions contemplated hereby.

         7.  Covenants of the Company.  Until such time as Purchasers  and their
affiliates beneficially own less than one percent (1%) of the Common Stock after
giving  effect to the  conversion  or exercise of all  securities of the Company
beneficially owned by Purchasers and their affiliates, the Company covenants and
agrees with Purchasers as follows:

         7.1.  Books and Accounts.  The Company  will:  (a) make and keep books,
records and accounts, which, in reasonable detail, accurately and fairly reflect
its transactions,  


                                       -9-


<PAGE>

including  without  limitation,  dispositions of its assets;  and (b) devise and
maintain  a  system  of  internal  accounting  controls  sufficient  to  provide
reasonable  assurances  that (i)  transactions  are executed in accordance  with
management's general or specific  authorization,  (ii) transactions are recorded
as necessary to permit  preparation of financial  statements in conformity  with
generally  accepted  accounting  principles and in accordance with the Company's
past  practices or any other  criteria  applicable  to such  statements,  and to
maintain  accountability for assets, (iii) access to assets is permitted only in
accordance with  management's  general or specific  authorization,  and (iv) the
recorded  accountability  for assets is  compared  with the  existing  assets at
reasonable  intervals  and  appropriate  action  is taken  with  respect  to any
differences.

         7.2.  Periodic  Reports.  (a) The Company will furnish to Purchasers as
soon as  practicable,  and in any  event  within  90 days  after the end of each
fiscal year of the Company  (commencing  with the fiscal year ended December 31,
1996, an annual  report of the Company,  including a balance sheet as at the end
of such fiscal year and statement of operations,  stockholders' equity (deficit)
and cash flows for such fiscal year,  together with the related  notes  thereto,
setting forth in each case in  comparative  form  corresponding  figures for the
preceding  fiscal  year,  all of which will be  correct  and  complete  and will
present  fairly the  financial  position  of the  Company and the results of its
operations  and  changes in its  financial  position  as of the time and for the
period  then  ended.  Such  financial  statements  shall  be  accompanied  by an
unqualified  report  (other than  qualifications  contingent  upon the Company's
ability  to  obtain  additional  financing),  in form and  substance  reasonably
satisfactory  to  Purchasers,   of  independent  public  accountants  reasonably
satisfactory  to Purchasers to the effect that such  financial  statements  have
been  prepared  in  accordance  with the books and  records of the  Company  and
generally  accepted  accounting  principles  applied on a basis  consistent with
prior years (except as otherwise  specified in such report),  and present fairly
the  financial  position of the Company  and the results of its  operations  and
changes  in their  financial  position  as of the time and for the  period  then
ended.  The Company  will use its best  efforts to conduct its  business so that
such  report  of  the  independent  public  accountants  will  not  contain  any
qualifications as to the scope of the audit, the continuance of the Company,  or
with respect to the Company's  compliance  with  generally  accepted  accounting
principles  consistently applied, except for changes in methods of accounting in
which such accountants concur.

         (b) The Company will furnish to Purchasers,  as soon as practicable and
in any event  within 45 days  after  the end of each of the first  three  fiscal
quarters of the  Company  during each  fiscal  year,  a quarterly  report of the
Company  consisting of an unaudited  balance sheet as at the end of such quarter
and an unaudited  statement of operations,  stockholders'  equity  (deficit) and
cash flows for such  quarter  and the  portion of the  fiscal  year then  ended,
setting forth in each case in  comparative  form  corresponding  figures for the
preceding  fiscal  year.  All such  reports  shall  be  certified  by the  Chief
Financial  Officer or Vice President--  Finance of the Company to be correct and
complete,  to present  fairly the  financial  position  of the  Company  and the
consolidated  results of its operations and changes in its financial position as
of the  time  and  for the  period  then  ended  and to have  been  prepared  in
accordance with generally accepted accounting principles.

         (c) The Company shall furnish to  Purchasers,  within 30 days after the
end of each calendar month, an unaudited  balance sheet of the Company as of the
end  of  such  month  and  the  related   unaudited   statement  of  operations,
stockholders'  equity (deficit) and cash flows for such month and for the fiscal
year to date,  setting  forth in each case  comparative  form the  corresponding
figures  for the budget for the current  fiscal  year,  or such other  financial
information as otherwise  agreed to by the parties  hereto.  All such statements
shall be certified by the Chief Financial Officer or Vice  President--Finance of
the  Company to the effect that such  statements  fairly  present the  financial
condition of the Company as of the dates shown and the results of its operations
for the  periods  then  ended and that such  statements  have been  prepared  in
conformity with generally accepted accounting  principles  consistently  applied
except for normal,  recurring,  year-end  audit  adjustments  and the absence of
footnotes.

         (d) Commencing  with the Company's  fiscal year  commencing  January 1,
1997, the Company shall furnish to Purchasers, as soon as practicable and in any
event not less than 60 days prior to the end of each fiscal year of the Company,
(i) an annual operating budget for the Company,  for the succeeding fiscal year,
containing  projections of profit and loss,  cash flow and ending balance sheets
for each month of such fiscal  year and (ii)


                                      -10-


<PAGE>

a business plan for the Company as specified in Section 7.19.  The Company shall
furnish to Purchasers within five days after the date the Board of Directors has
approved the annual operating budget and business plan referred to above,  which
shall be no later than 60 days after the  beginning  of each fiscal  year,  such
operating  budget  and  business  plan as  approved  by the Board of  Directors.
Promptly upon preparation  thereof,  the Company shall furnish to Purchasers any
other  operating  budgets or business plans that the Company may prepare and any
revisions or  modifications  of such  previously  furnished  budgets or business
plans.

         (e) The annual statements and quarterly  statements  furnished pursuant
to Sections 7.02(a) and (b) shall include a narrative discussion prepared by the
Company  describing  the business  operations  of the Company  during the period
covered by such statements. The monthly statements furnished pursuant to Section
7.02(c) shall be  accompanied  by a statement  describing  any material  events,
transactions or deviations  from the Company's  Business Plan (as defined below)
contemplated  by Section 7.19 and  containing an  explanation  of the causes and
circumstances thereof.

         7.3.  Certificates of Compliance.  The Company  covenants that promptly
after the occurrence of any default  hereunder or any default under or breach of
any material  agreement,  or any other  material  adverse event or  circumstance
affecting the Company,  it will deliver to  Purchasers an Officers'  Certificate
specifying in reasonable detail the nature and period of existence thereof,  and
what actions the Company has taken and proposes to take with respect thereto.

         7.4.  Other  Reports and  Inspection.  (a) The Company  will furnish to
Purchasers (a) as soon as practicable  after  issuance,  copies of any financial
statements  or reports  prepared by the Company for, or otherwise  furnished to,
its  stockholders  or the Securities  and Exchange  Commission and (b) promptly,
such other  documents,  reports and financial  data as Purchasers may reasonably
request.  In addition the Company  will,  upon  reasonable  prior  notice,  make
available to  Purchasers  or its  representatives  or designees  (a) all assets,
properties and business records of the Company for inspection and/or copying and
(b)  the  directors,  officers  and  employees  of the  Company  for  interviews
concerning the business, affairs and finances of the Company.

         7.5. [Intentionally Omitted.]

         7.6.  Insurance.  The Company will at all times maintain valid policies
of worker's compensation and such other insurance with respect to its properties
and business of the kinds and in amounts not less than is customarily maintained
by corporations  engaged in the same or similar business and similarly situated,
including,  without  limitation,  insurance against fire, loss,  damage,  theft,
public  liability and other risks.  The activities and operations of the Company
shall be conducted in a manner to as to conform in all material  respects to all
applicable provisions of such policies.

         7.7. Use of Proceeds;  Restriction  on Payments.  The Company shall use
the net  proceeds  from the sale of the Bridge  Notes and Warrants to bridge its
working  capital needs through such time as it can consummate an offering of its
securities.  The  Company  covenants  and agrees  that it will not  directly  or
indirectly use any of the proceeds to (i) repay any indebtedness of the Company,
including but not limited to any indebtedness to officers, employees,  directors
or  principal  stockholders  of the  Company,  but  excluding  accounts  payable
incurred  in the  ordinary  course of  business or (ii)  redeem,  repurchase  or
otherwise  acquire  any equity  security  of the  Company.  Notwithstanding  the
foregoing,  the Company  shall not make any payments to any parties which exceed
$10,000 without the prior written consent of the Partnership and the Trust.

         7.8. Material  Changes.  The Company will promptly notify Purchasers of
any material  adverse change in the business,  properties,  assets or condition,
financial or otherwise,  of the Company,  or any other material adverse event or
circumstance  affecting  the  Company,  and of any  litigation  or  governmental
proceeding  pending or, to the knowledge of the Company,  threatened against the
Company or against any director or officer of the Company.

         7.9.   Transactions  with  Affiliates.   Except  for  the  transactions
contemplated  by  this  Agreement,  the  Company  shall  not (a)  engage  in any
transaction  with,  (b) make any loans  to,  nor (c)  enter  into any  contract,
agreement or other  arrangement (i) providing for (x) the employment of, (y) the
furnishing of services by, or (z) the rental of real or personal  property from,
or (ii) otherwise  requiring payments to, any officer,  director or 


                                      -11-


<PAGE>

key  employee  of the  Company  or any  relative  of such  persons  or any other
"affiliate"  or  "associate"  of such  persons (as such terms are defined in the
rules and regulations  promulgated under the Securities Act),  without the prior
written approval of the Partnership and the Trust.

         7.10.  Corporate  Existence,   Licenses  and  Permits;  Maintenance  of
Properties;  New Businesses.  The Company will at all times conduct its business
in the  ordinary  course and cause to be done all things  necessary to maintain,
preserve and renew its existence and will preserve and keep in force and effect,
all  licenses,  permits and  authorizations  necessary to the conduct of its and
their  respective  businesses.  The  Company  will  also  maintain  and keep its
properties in good repair,  working order and condition,  and from time to time,
to make all needful and proper repairs,  renewals and replacements,  so that the
business  carried on in connection  therewith  may be properly  conducted at all
times.

         7.11. Other Material Obligations. The Company will comply with, (a) all
material  obligations which it is subject to, or becomes subject to, pursuant to
any contract or  agreement,  whether oral or written,  as such  obligations  are
required to be observed or performed, unless and to the extent that the same are
being contested in good faith and by appropriate proceedings and the Company has
set aside on its books  adequate  reserves  with  respect  thereto,  and (b) all
applicable laws,  rules, and regulations of all  governmental  authorities,  the
violation of which could have a material adverse effect upon the business of the
Company.

         7.12.  Amendment to the Certificate of  Incorporation  and the By-Laws.
The  Company  will  perform  and be in  compliance  with and  observe all of the
provisions  set forth in its  Certificate  of  Incorporation  and By-Laws to the
extent that the performance of such obligations is legally permissible; provided
that the fact that performance is not legally  permissible will not prevent such
nonperformance  from constituting an event of default under this Agreement.  The
Company  will not amend its  Certificate  of  Incorporation  or  By-Laws  or any
Certificate  of  Designations  for any other  series of  Preferred  Stock of the
Company so as to adversely affect the rights of Purchasers under this Agreement,
the Certificate of  Incorporation,  the By-Laws,  the Warrants,  the Notes,  the
Security Agreement or the Series D Preferred Stock Certificate of Designations.

         7.13.  Merger;  Sale of Assets.  The Company will not become a party to
any merger, consolidation or reorganization, or sell, lease, license, sublicense
or  otherwise  dispose of all or  substantially  all of its assets,  without the
prior approval of Purchasers.

         7.14.  Acquisition.  The Company  will not acquire any  interest in any
business  from any  person,  firm or entity  (whether  by a purchase  of assets,
purchase  of  stock,   merger  or  otherwise)  without  the  prior  approval  of
Purchasers,  except the  acquisition  of 1% or less of any class of  outstanding
securities of a company  whose  securities  are listed on a national  securities
exchange or which has not fewer than 1,000  stockholders and except as otherwise
specifically permitted pursuant to the provisions of this Agreement.

         7.15. Dividends;  Distributions;  Repurchases of Common Stock; Treasury
Stock.  The Company shall not declare or pay any dividends on, or make any other
distribution  with  respect to, its  capital  stock,  whether  now or  hereafter
outstanding,  or purchase,  acquire,  redeem or retire any shares of its capital
stock, without the consent of Purchasers, provided, however, the foregoing shall
not prohibit the Company from  repurchasing  any shares of its Common Stock from
any present or former officer, Director or employee of the Company, or complying
with the terms and  provisions  of the  Series A  Preferred  Stock and  Series C
Preferred Stock.

         7.16.  Consents and Waivers.  (a) Except as set forth on Schedule 7.16,
the Company has obtained all consents and waivers needed to enable it to perform
all of its obligations  under this Agreement and the  transactions  contemplated
hereby.

         (b) Except as set forth on Schedule 7.16, the Company has obtained from
all holders of options,  warrants and other securities of the Company having any
right  of  first  refusal,   offer,  sale,  negotiation  or  similar  rights  or
antidilution or other rights to have the terms (including,  without  limitation,
conversion or exercise prices or rates) of such  instruments  adjusted by virtue
of the purchase and sale of the Notes and the Warrants or the other transactions
contemplated  by  this  Agreement,  a  written  waiver  in  form  and  substance
satisfactory to Purchasers and their counsel.


                                      -12-


<PAGE>

         7.17.  Taxes and Liens.  The Company will duly pay and  discharge  when
payable, all taxes, assessments and governmental charges imposed upon or against
the Company or its properties, or any part thereof or upon the income or profits
therefrom,  in each case before the same become  delinquent and before penalties
accrue thereon, as well as all claims for labor,  materials or supplies which if
unpaid  might by law become a lien upon any of its  property,  unless and to the
extent  that the same are  being  contested  in good  faith  and by  appropriate
proceedings  and the Company has set aside on its books  adequate  reserves with
respect thereto.

         7.18.  Restrictive  Agreement.  The Company  covenants  and agrees that
subsequent to the Closing, it will not be a party to any agreement or instrument
which by its terms would restrict the Company's  performance of its  obligations
pursuant to this  Agreement,  the  Certificate of  Incorporation,  By-laws,  the
Warrants or the Notes.

         7.19.  Business  Plan.   Commencing  with  the  Company's  fiscal  year
commencing  January 1,  1997,  the  Company's  Chief  Financial  Officer or Vice
President--  Finance  shall  prepare or have prepared and submit to the Board of
Directors  not less than 60 days prior to the  beginning  of each fiscal year of
the Company,  an updated business plan (the "Business Plan") for such year which
shall set forth the  Company's  product  development,  marketing  and  servicing
plans,  capital expenditures and expense budgets and shall encompass a statement
of long range strategy over a five-year  period and  short-range  tactics over a
two-year  period.  The Business Plan shall specify  quantitative and qualitative
goals for the Company and relate the  attainment of those goals to the Company's
strategic objectives.

         7.20.  Director and Observer.  (a) For a period of five years after the
Closing  Date,  the  Partnership  and the Trust shall be entitled to designate a
majority of the voting Directors of the Company provided,  however,  that in the
event that the Company has not obtained Future  Financings (as defined below) in
excess of  $3,500,000  on or before the date which is 6 months  after the Bridge
Closing Date (as defined in Exhibit B), then the Partnership and the Trust shall
have the right to appoint only 2 Directors or observers and the remainder of the
Partnership and the Trust's designated  Directors shall resign. In addition,  if
the holders of the Series A Preferred  Stock  exercise their right to appoint up
to 2 additional  Directors pursuant to Section 9(c) of the Restated  Certificate
of  Incorporation  of  the  Company  (the  "Restated  Certificate"),   then  the
Partnership  and the Trust  shall have the right to  appoint up to 2  additional
Directors  per  Director  appointed  by the Series A  Preferred  Stock.  "Future
Financings"  shall  mean the  aggregate  gross  proceeds  of any sales of equity
securities  of  the  Company  (including  the  Notes  or  any  other  securities
convertible  into equity  securities  of the Company),  and the aggregate  gross
proceeds of any corporate  partnering or corporate licensing  transactions,  but
shall  exclude  the sale of  products in the  ordinary  course of  business  and
revenues  resulting from any agreement in effect as of the Closing Date. Without
limiting the generality of the foregoing,  such Future Financing  includes:  (a)
all  payments  made for equity  securities,  equity  security  rights or similar
rights, (b) technology  acquisition or access fees or similar up-front payments,
(c) other future  payments to be made to the Company,  any of its  affiliates or
its employees  for the benefit of the Company,  for which the payor is obligated
either absolutely or upon the attainment of milestones,  (d) funding provided by
any  investor  (through  reimbursement  or  otherwise)  relative to research and
development,  clinical trials and related expenditures,  provided that such work
is  performed  or managed by the  Company or any of its  affiliates  and (e) the
repayment or assumption by any party of obligations of the Company or any of its
affiliates,  including  indebtedness  for money  borrowed or amounts owed by the
Company or any of its  affiliates  to inventors or owners of  technology.  It is
further  understood that Future Financings shall not be reduced by the amount of
any expenses,  fees, discounts or commissions incurred during the undertaking of
such financing. If necessary,  the Directors of the Company will elect each such
person to the Board of  Directors  of the Company by creating a new  position on
the Board of Directors promptly following such person's nomination by Purchasers
and shall nominate such person for election in connection  with any  stockholder
vote for Directors, and the Company will use its best efforts to ensure that the
stockholders of the Company agree to vote all their  securities in favor of such
person's  election.  The Company agrees to vote all voting  securities for which
the Company  holds  proxies,  granting  it voting  discretion,  or is  otherwise
entitled  to vote,  in favor of, and to use its best  efforts in all  respect to
cause, the election of each such individual  proposed by the Partnership and the
Trust.  In the event that a vacancy is created on the Board of  Directors at any
time by the death, disability, resignation or removal (with or without cause) of
any such  individual  proposed and nominated by the  Partnership  and the Trust,
pursuant to this  Agreement,  the Company will, and will use its best efforts to
ensure that the stockholders of the Company, vote


                                      -13-


<PAGE>

all its voting  securities to elect each individual  proposed by the Partnership
and the Trust and  approved  by the Company and  nominated  for  election by the
Partnership and the Trusts to fill such vacancy and serve as a voting Director.

         (b) In  addition to the rights set forth in Section  7.20(a),  from and
after the Closing Date,  until such time as Purchasers or their affiliates shall
not  beneficially  own any securities of the Company,  the  Partnership  and the
Trust shall be entitled to designate  nonvoting  observers who shall be entitled
to attend all meetings of the Board of Directors and any of its  committees  and
who shall be provided (i)  reasonable  prior notice of all meetings of the Board
of Directors  and any of its  committees,  (ii)  reasonable  prior notice of any
action that the Board of Directors or any of its  committees may take by written
consent,  (iii)  promptly  delivered  copies of all minutes and other records of
action by, and all written  information  furnished to, the Board of Directors or
any of its committees and (iv) any other information  requested by such observer
which a member  of the  Board of  Directors  would be  entitled  to  request  to
discharge his or her duties. Such observers shall be entitled to the same rights
to  reimbursement  for the  expense of  attendance  at  meeting  as any  outside
Director.

         (c) If the  Partnership  and the Trust give notice to the Company  that
the  Partnership  and the  Trust  desire to remove a  Director  proposed  by the
Partnership  and the Trust pursuant to this  Agreement,  the Company shall,  and
shall use its best effort to ensure that the  stockholders of the Company shall,
vote all its voting  securities  in favor of removing such Director if a vote of
holders of such  securities  shall be required to remove the  Director,  and the
Company agrees to take any action necessary to facilitate such removal.

         (d) Each Director  nominated by the  Partnership and the Trust shall be
entitled  to the same type and an amount of  compensation  at least equal to the
highest amount payable to any other Director for serving in such capacity.

         (e) Concurrently with the Closing Date, if requested by the Partnership
and the Trust,  the  Company  shall have caused the  appointment  of the initial
Directors  nominated by the Partnership and the Trust, to its Board of Directors
in accordance with the provisions of this Section 7.20, which  individuals shall
be identified in writing to the Company by such time.

         (f) At any time that a designee or designees of the Partnership and the
Trust serve on the Company's  Board of Directors,  the Partnership and the Trust
shall be entitled to  representation  on any committee of the Board of Directors
proportionate with their representation of the Board as a whole.

         7.21. Board of Directors. (a) The Company shall promptly reimburse each
director or observer of the Company  designated by the Partnership and the Trust
who  is not an  employee  of the  Company  for  all of his  reasonable  expenses
incurred in  attending  each meeting of the Board of Directors of the Company or
any committee thereof.

         (b) The Company shall at all times  maintain  provisions in its By-laws
and/or Certificate of Incorporation indemnifying all directors against liability
and absolving all directors from  liability to the Company and its  stockholders
to the maximum extent permitted under the laws of the State of Delaware.

         (c)  The  By-laws  of  the  Company  shall  always  contain  provisions
consistent  with the  provisions  of this Section 7.21 except to the extent this
Section 7.21 deals with the possible observer.

         (d) For so long as any  designee  of  Purchasers  is a director  of the
Company,  procure and maintain Director and Officer  Liability  Insurance with a
reputable insurance carrier.

         7.22.  No  Subsidiaries.  The  Company  will not create or acquire  any
entity  that would be a  Subsidiary  (as  defined in Section  9.10)  without the
Partnership's and the Trust's consents.

         7.23.  Publicity.  (a) The Company shall not issue any press release or
make any  other  public  announcement  with  respect  to this  Agreement  or the
transactions  contemplated  hereby or utilizing the names of Purchasers or their
officers, directors, employees, agents or affiliates without obtaining the prior
approval of Purchaser,  except 


                                      -14-


<PAGE>

as may be required by law or the  regulations of any securities  exchange or the
Nasdaq National Market.

         (b)  Except  as may be  required  by  law  or  the  regulations  of any
securities  exchange  or the  Nasdaq  National  Market,  the  Company  shall not
disclose the names, identity,  addresses or any other information regarding each
of the Purchasers or any of its officers,  directors,  employees,  shareholders,
nominees  and/or  designees  without such  Purchaser's  prior  written  consent;
provided,  however,  each of the names of Purchasers (but not its addresses) may
be disclosed in the Shelf Registration Statement.

         (c) After the Closing  Date,  upon request of the  Partnership  and the
Trust, the Company shall cause, at its sole expense,  the immediate  publication
of a "tombstone"  advertisement  in the Wall Street Journal  (National  Edition)
announcing the consummation of this Agreement and the transactions  contemplated
herein,  the exact form and substance of which shall be mutually  agreed upon by
the Company and the Partnership and the Trust.

         7.24. Restriction on Securities. (a) During the 18 months following the
Closing  Date,  the  Company  shall not  without  prior  written  consent of the
Partnership  and the  Trust,  issue,  offer  or sell any of its  equity  or debt
securities  (including,  without limitation,  any securities convertible into or
exercisable for such securities);  provided that the Company may issue shares of
Common Stock upon conversion or exercise of the Company's outstanding securities
and  pursuant to exercise of options  under the  Company's  Stock Option Plan in
accordance with the terms of such plan (it being agreed that the issuance of any
additional  options  under such plan may be effected only with the prior written
consent of the Partnership and the Trust;  provided,  further,  that the Company
without the consent of the Partnership and the Trust may issue options under the
Company's  Non-Employee  Director Stock Option Plan in accordance with the terms
of such plan which will not be amended  without the consents of the  Partnership
and the Trust); provided, further, that this Section 7.24 shall not apply to the
offerings to be conducted by the Company with Paramount Capital,  Inc. acting as
placement agent as contemplated in the Letter Agreement  between the Company and
Paramount  Capital,  Inc.  dated as of January 28,  1997.  During the  18-months
following  the Closing Date,  the Company  shall not,  without the prior written
consents  of the  Partnership  and the  Trust,  offer or sell any of its debt or
equity  securities in reliance on Regulation S of the Securities Act. During the
36-month  period  following  the Closing  Date,  the Company will not extend the
expiration date or lower the exercise price of any options or warrants,  or take
any similar  action with respect to any  convertible  securities of the Company,
without the prior written consents of the Partnership and the Trust.

         (b) Prior to the Closing  Date,  the Company  shall  obtain the written
agreement of all executive  officers and directors of the Company (and shall use
its  best  efforts  to  obtain  a  wrtten  agreement  from  all  5%  or  greater
stockholders  of the  Company) to  "lock-up"  all of the shares of Common  Stock
owned by each of them at any time until 24 months  following  the Closing  Date,
and to agree not to directly or indirectly, issue, agree or offer to sell, grant
an option for the purchase or sale, assign, sell, contract to sell, sell "short"
or "short  against the box" (as those terms are generally  understood),  pledge,
hypothecate,  distribute  or  otherwise  encumber or dispose of, any such shares
(including  options,  rights,  warrants or other  securities  convertible  into,
exchangeable,  exercisable  for or evidencing any right to purchase or subscribe
for shares of capital stock of the Company (whether or not beneficially owned by
the undersigned) or any beneficial  interest therein of any shares of the Common
Stock,  all in form and substance  satisfactory to the Partnership and the Trust
and their counsel.

         7.25.  Restriction on Liens. The Company shall not create or permit the
imposition  of any liens on any of its assets  from and after the  Closing  Date
without the prior written consent of the Partnership and the Trust.

         7.27.  Restrictions  on  Indebtedness.  The  Company  shall not  incur,
create,  assume  or permit to exist any  indebtedness  except  (i)  indebtedness
represented by the Notes, (ii)  indebtedness  which by its terms is subordinated
to the Notes in an amount less than $25,000 in the aggregate (iii)  indebtedness
in an amount less than fifty thousand dollars ($50,000) incurred in the ordinary
course of business,  and (iv)  indebtedness  for borrowed  money existing on the
date  hereof and  disclosed  in writing to the Holder,  but not any  extensions,
renewals or replacements of such indebtedness.

         7.28. Repayment Upon Certain Events. In the event that the Company does
not obtain the  Required  Shareholder  Approvals  (as  hereafter  defined),  the
Company shall, on 


                                      -15-


<PAGE>

the date that the Required Shareholder Approvals are denied,  immediately pay to
the Purchasers by wire transfer $3,000,000 or in the event that the Company does
not have $3,000,000, the remainder of the money that the Company has as a result
of the  investment  made by  Purchasers  in the  Company  pursuant  to the terms
hereof.  The "Required  Shareholder  Approvals" shall mean the authorization and
approval  by the holders of Common  Stock of the Company of the  issuance of the
Notes,  the issuance of the shares of Series D Preferred Stock  underlying these
Notes,  the  Bridge  Warrants  or the New  Warrants  (as  defined  in the Bridge
Warrants),  or any Common  Stock  underlying  the  foregoing  to the extent such
authorization  is necessary  pursuant to the rules of the Nasdaq National Market
or any other applicable law, rule or regulation.

         8. Registration of Common Stock.

         8.1.  Registration.  (i) Not later than 30 days after consummation of a
Qualified  Offering  (as  defined  below) or, (ii) in the event that a Qualified
Offering (as defined  below) has not been  consummated  by the date which is 180
days after the Closing Date,  immediately  thereafter and in no event later than
the date which is 195 days from the Closing Date,  the Company will file a shelf
registration statement (the "Shelf Registration  Statement") with respect to the
resale  of  the   Registrable   Securities  with  the  Securities  and  Exchange
Commission.  The Company will use its best efforts to effect the  registrations,
qualifications or compliances (including,  without limitation,  the execution of
any  required  undertaking  to  file  post-effective   amendments,   appropriate
qualifications  under  applicable  blue sky or other state  securities  laws and
appropriate   compliance  with  applicable  securities  laws,   requirements  or
regulations)  as may be  reasonably  requested and as would permit or facilitate
that sale and distribution of all Registrable  Securities until the distribution
thereof is complete.  A "Qualified  Offering"  shall mean any equity offering or
series of Offerings with gross proceeds in excess of $2,500,000.

         8.2.  Registration  Procedures.  In connection with the registration of
any Registrable  Securities under the Securities Act as provided in this Section
8, the Company will use its best efforts, as expeditiously as possible:

         (a) Prepare and file with the  Securities  and Exchange  Commission the
Shelf Registration Statement with respect to such Registrable Securities and use
its best efforts to cause such Shelf Registration Statement to become effective;

         (b) Prepare and file with the Securities and Exchange  Commission  such
amendments  and  supplements  to  such  Shelf  Registration  Statement  and  the
prospectus  used in connection  therewith as may be necessary to keep such Shelf
Registration  Statement  effective  until the  disposition  of all securities in
accordance  with the intended  methods of  disposition  by the seller or sellers
thereof set forth in such Shelf Registration  Statement shall be completed,  and
to comply with the provisions of the Securities Act (to the extent applicable to
the Company) with respect to such dispositions;

         (c) Furnish to each seller of such  Registrable  Securities such number
of copies of such Shelf  Registration  Statement and of each such  amendment and
supplement thereto (in each case including all exhibits),  such number of copies
of the prospectus included in such Shelf Registration  Statement (including each
preliminary  prospectus),  in conformity with the requirements of the Securities
Act, and such other documents,  as such seller may reasonably  request, in order
to  facilitate  the  disposition  of the  Registrable  Securities  owned by such
seller;

         (d) Use its best  efforts  to  register  or  qualify  such  Registrable
Securities  covered  by such  Shelf  Registration  Statement  under  such  other
securities  or blue  sky laws of such  jurisdictions  as any  seller  reasonably
requests,  and do any and all other  acts and  things  which  may be  reasonably
necessary or advisable to enable such seller to consummate  the  disposition  in
such  jurisdictions of the Registrable  Securities owned by such seller,  except
that the Company will not for any such purpose be required to qualify  generally
to do business as a foreign  corporation  in any  jurisdiction  wherein it would
not,  but for the  requirements  of  this  Section  8.2(d)  be  obligated  to be
qualified, to subject itself to taxation in any such jurisdiction, or to consent
to general service of process in any such jurisdiction;

         (e) Provide a transfer  agent and  registrar  for all such  Registrable
Securities  covered  by such  Shelf  Registration  Statement  not later than the
effective date of such Shelf Registration Statement;


                                      -16-


<PAGE>

         (f) Notify each seller of such Registrable  Securities at any time when
a prospectus  relating  thereto is required to be delivered under the Securities
Act, of the happening of any event as a result of which the prospectus  included
in such Shelf Registration  Statement contains an untrue statement of a material
fact or omits any fact necessary to make the statements  therein not misleading,
and, at the request of any such seller, the Company will prepare a supplement or
amendment to such prospectus so that, as thereafter  delivered to the purchasers
of such  Registrable  Securities,  such  prospectus  will not  contain an untrue
statement  of a material  fact or omit to state any fact  necessary  to make the
statements therein not misleading;

         (g)  Cause  all  such  Registrable  Securities  to be  listed  on  each
securities  exchange  or  automated  over-the-counter  trading  system  on which
similar securities issued by the Company are then listed;

         (h)  Enter  into  such  customary  agreements  and take all such  other
actions  as  reasonably   required  in  order  to  expedite  or  facilitate  the
disposition of such Registrable Securities; and

         (i)  Make  available  for  inspection  by  any  seller  of  Registrable
Securities, all financial and other records, pertinent corporation documents and
properties  of the Company,  and cause the  Company's  officers,  directors  and
employees to supply all information  reasonably  requested by any such seller in
connection with the Shelf Registration Statement pursuant to Section 8.1.

         8.3 Registration and Selling Expenses. (a) All expenses incurred by the
Company in connection with the Company's  performance of or compliance with this
Section 8, including,  without  limitation (i) all  registration and filing fees
(including  all  expenses  incident to filing with the National  Association  of
Securities Dealers, Inc.), (ii) blue sky fees and expenses,  (iii) all necessary
printing and duplicating expenses and (iv) all fees and disbursements of counsel
and  accountants  for the  Company  (including  the  expenses  of any  audit  of
financial  statements),  retained by the Company (all such expenses being herein
called "Registration Expenses"), will be paid by the Company except as otherwise
expressly provided in this Section 8.3.

         (b) The Company will, in any event, in connection with any registration
statement,  pay  its  internal  expenses  (including,  without  limitation,  all
salaries and expenses of its officers and employees performing legal, accounting
or other  duties in  connection  therewith  and  expenses  of audits of year-end
financial  statements),  the expense of liability insurance and the expenses and
fees for listing  the  securities  to be  registered  on one or more  securities
exchanges  or  automated  over-the-counter  trading  systems  on  which  similar
securities issued by the Company are then listed.

         (c) Nothing  herein shall be construed to prevent any holder or holders
of  Registrable  Securities  from  retaining  such  counsel  (the  Trust and the
Partnership  to be limited to one counsel  representing  them both and any other
purchasers to be  represented by one counsel  separately  from the Trust and the
Partnership)  as they shall choose,  the expenses of which shall be borne by the
Company.

         8.4. Other Public Sales and  Registrations.  The Company agrees that it
will  not,  on its own  behalf,  file or cause to  become  effective  any  other
registration  of any of its  securities  under the  Securities  Act or otherwise
effect a public  sale or  distribution  of its  securities  (except  pursuant to
registration on Form S-8 or any successor form relating to a special offering to
the employees or security  holders of the Company)  until at least 180 days have
elapsed  after  the  effective  date of the  Shelf  Registration  Statement.  In
addition,  the Company  agrees that it will use its best efforts to obtain prior
to the  filing of the Shelf  Registration  Statement  an  agreement  in form and
substance  satisfactory  to  Purchasers  and  their  counsel  in their  sole and
absolute discretion from each person that has the right to have the Company file
or cause to become  effective any other  registration  of any of its  securities
under the Securities Act or otherwise  effect a public sale or  distribution  of
its securities  (except  pursuant to  registration  on Form S-8 or any successor
form relating to a special  offering to the employees or security holders of the
Company),  pursuant  to which each such person will agree for the benefit of the
Company and  Purchasers to waive any and all such rights until at least 180 days
have elapsed after the effective date of the Shelf Registration Statement.

         8.5.  Indemnification.  (a) The Company hereby agrees to indemnify,  to
the extent permitted by law, each holder of Registrable Securities, its officers
and 


                                      -17-


<PAGE>

directors,  if any, and each person, if any, who controls such holder within the
meaning of the Securities Act, against all losses, claims, damages,  liabilities
and expenses (under the Securities Act or common law or otherwise) caused by any
untrue statement or alleged untrue statement of a material fact contained in any
registration  statement or  prospectus  (and as amended or  supplemented  if the
Company has furnished any amendments or supplements  thereto) or any preliminary
prospectus,  which registration statement,  prospectus or preliminary prospectus
shall be prepared  in  connection  with the  registration  contemplated  by this
Section 8, or caused by any  omission  or alleged  omission  to state  therein a
material fact required to be stated  therein or necessary to make the statements
therein  not  misleading,  except  insofar  as  such  losses,  claims,  damages,
liabilities  or expenses are caused by any untrue  statement  or alleged  untrue
statement  contained in or by any omission or alleged  omission from information
furnished  in  writing by such  holder to the  Company  in  connection  with the
registration  contemplated  by this Section 8,  provided the Company will not be
liable pursuant to this Section 8.5 if such losses, claims, damages, liabilities
or expenses have been caused by any selling security holder's failure to deliver
a copy  of the  registration  statement  or  prospectus,  or any  amendments  or
supplements thereto, after the Company has furnished such holder with the number
of copies required by Section 8.2(c).

         (b) In connection with any registration  statement in which a holder of
Registrable  Securities is participating,  each such holder shall furnish to the
Company in writing such  information  as is reasonably  requested by the Company
for use in any such  registration  statement or prospectus and shall  severally,
but not jointly,  indemnify,  to the extent  permitted by law, the Company,  its
directors and officers and each person,  if any, who controls the Company within
the  meaning  of the  Securities  Act,  against  any  losses,  claims,  damages,
liabilities and expenses  resulting from any untrue  statement or alleged untrue
statement of a material  fact or any omission or alleged  omission of a material
fact  required to be stated in the  registration  statement or prospectus or any
amendment  thereof or  supplement  thereto or necessary  to make the  statements
therein not  misleading,  but only to the extent such losses,  claims,  damages,
liabilities  or expenses  are caused by an untrue  statement  or alleged  untrue
statement contained in or by an omission or alleged omission from information so
furnished  in  writing  by such  holder  in  connection  with  the  registration
contemplated  by  this  Section  8.  If  the  offering   pursuant  to  any  such
registration is made through underwriters, each such holder agrees to enter into
an  underwriting  agreement  in  customary  form with such  underwriters  and to
indemnify such  underwriters,  their  officers and  directors,  if any, and each
person who controls such  underwriters  within the meaning of the Securities Act
to the same extent as hereinabove  provided with respect to  indemnification  by
such holder of the Company. Notwithstanding the foregoing or any other provision
of this  Agreement,  in no event  shall a holder of  Registrable  Securities  be
liable for any such losses, claims,  damages,  liabilities or expenses in excess
of the lesser of (a) the net proceeds received by such holder in the offering or
(b) $1,000,000.

         (c) Promptly  after receipt by an  indemnified  party under Section 8.5
(a) or (b) of notice of the  commencement  of any  action  or  proceeding,  such
indemnified  party  will,  if a claim in  respect  thereof is made  against  the
indemnifying party under such Section,  notify the indemnifying party in writing
of the  commencement  thereof;  but the  omission so to notify the  indemnifying
party  will  not  relieve  it  from  any  liability  which  it may  have  to any
indemnified party otherwise than under such Section.  In case any such action or
proceeding  is brought  against  any  indemnified  party,  and it  notifies  the
indemnifying party of the commencement  thereof,  the indemnifying party will be
entitled to participate therein, and, to the extent that it wishes, jointly with
any other indemnifying party similarly notified,  to assume the defense thereof,
with  counsel  approved by such  indemnified  party,  and after  notice from the
indemnifying  party to such  indemnified  party of its election so to assume the
defense thereof,  the indemnifying  party will not be liable to such indemnified
party  under  such  Section  for any  legal or any other  expenses  subsequently
incurred by such indemnified party in connection with the defense thereof (other
than reasonable costs of  investigation)  unless incurred at the written request
of the indemnifying party. Notwithstanding the above, the indemnified party will
have the  right to  employ  counsel  of its own  choice  in any such  action  or
proceeding if the indemnified  party has reasonably  concluded that there may be
defenses  available to it which are different from or additional to those of the
indemnifying  party, or counsel to the indemnified  party is of the opinion that
it  would  not  be  desirable  for  the  same  counsel  to  represent  both  the
indemnifying party and the indemnified party because such  representation  might
result in a conflict  of  interest  (in either of which  cases the  indemnifying
party  will not have the  right to  assume  the  defense  of any such  action or
proceeding  on behalf of the  indemnified  party or  parties  and such legal and
other expenses 


                                      -18-


<PAGE>

will be borne by the  indemnifying  party).  An  indemnifying  party will not be
liable  to any  indemnified  party  for any  settlement  of any such  action  or
proceeding effected without the consent of such indemnifying party.

         (d) If the  indemnification  provided  for in Section  8.5(a) or (b) is
unavailable  under  applicable  law to an  indemnified  party in  respect of any
losses, claims, damages or liabilities referred to therein, then each applicable
indemnifying  party,  in lieu of  indemnifying  such  indemnified  party,  shall
contribute to the amount paid or payable by such  indemnified  party as a result
of  such  losses,  claims,  damages  or  liabilities  in such  proportion  as is
appropriate  to reflect the relative fault of the Company on the one hand and of
the  holders  of  Registrable  Securities  on the other in  connection  with the
statements  or omissions  which  resulted in such losses,  claims,  damages,  or
liabilities,  as  well  as any  other  relevant  equitable  considerations.  The
relative  fault of the Company on the one hand and of the holders of Registrable
Securities on the other shall be determined by reference to, among other things,
whether  the  untrue or  alleged  untrue  statement  of a  material  fact or the
omission to state a material fact relates to information supplied by the Company
or by the holders of Registrable  Securities and the parties'  relative  intent,
knowledge,  access to  information  and  opportunity  to correct or prevent such
statement or omission.  The amount paid or payable by a party as a result of the
losses,  claims,  damages and  liabilities  referred to above shall be deemed to
include,  subject to the limitations  set forth in Section 8.5(c),  any legal or
other fees or  expenses  reasonably  incurred by such party in  connection  with
investigating  or defending any action or claim.  No person guilty of fraudulent
misrepresentation  (within the meaning of Section 11(f) of the  Securities  Act)
will be  entitled  to  contribution  from any  person  who is not guilty of such
fraudulent misrepresentation.

         (e) Promptly  after  receipt by the Company or any holder of Securities
of notice of the commencement of any action or proceeding, such party will, if a
claim for  contribution  in respect  thereof is to be made against another party
(the  "contributing  party"),  notify the contributing party of the commencement
thereof;  but the omission so to notify the contributing  party will not relieve
it from any  liability  which  it may have to any  other  party  other  than for
contribution  hereunder. In case any such action, suit, or proceeding is brought
against  any  party,  and  such  party  notifies  a  contributing  party  of the
commencement  thereof,  the  contributing  party will be entitled to participate
therein with the  notifying  party and any other  contributing  party  similarly
notified.

         8.6.  Additional Common Stock Issuable Upon Delay of Registration.  (a)
Except to the extent any delay is due to the  failure of a holder to  reasonably
cooperate in providing to the Company such  information  as shall be  reasonably
requested by the Company in writing for use in the Shelf Registration Statement,
if the  Shelf  Registration  Statement  is not  filed  with the  Securities  and
Exchange  Commission  within the target dates set forth in the first sentence of
Section 8.1 (the "Outside  Target Date"),  the Company shall declare and pay for
no additional  consideration  to Purchasers  additional  Bridge  Warrants or New
Warrants,  as the case may be,  equal to 1.5% of the Bridge  Warrants or the New
Warrants,  as the case may be,  then held by  Purchasers  for each day after the
Outside Target Date that the Registration Statement remains unfiled.

         (b) If the Shelf  Registration  Statement is not declared  effective by
the  Securities  and Exchange  Commission  within 210 days following the Closing
Date (the "Targeted  Effective Date"),  the Company shall declare and pay for no
additional  consideration  to  Purchasers  additional  Bridge  Warrants  or  New
Warrants,  as the case may be,  equal to 1.5% of the Bridge  Warrants or the New
Warrants,  as the case may be,  then held by  Purchasers  for each day the Shelf
Registration  Statement is not declared effective by the Securities and Exchange
Commission following the occurrence of the Targeted Effective Date.

         (c) All shares of Common Stock issuable  pursuant to Section 8.6(a) and
(b) shall be duly  authorized,  fully  paid and  nonassessable  shares of Common
Stock and shall be included in the Shelf Registration  Statement contemplated by
Section 8.1. Such shares shall be registered in Purchasers' names or the name of
the nominee(s) of Purchasers in such  denominations  as Purchasers shall request
pursuant to instructions delivered to the Company.

         9.  Certain  Definitions.  For  the  purposes  of  this  Agreement  the
following terms have the respective meanings set forth below:


                                      -19-


<PAGE>

         9.1.  "Affiliate" means any person,  corporation,  firm or entity which
directly or indirectly  controls,  is controlled  by, or is under common control
with the indicated person, corporation, firm or entity.

         9.2. "Common Stock" means the Company's Common Stock.

         9.3.  "Generally   Accepted  Accounting   Principles"  means  generally
accepted accounting principles consistently applied.

         9.4. "Officers'  Certificate" means a certificate executed on behalf of
the Company by its President,  Chairman of the Board,  Chief Executive  Officer,
Chief Financial Officer,  Vice  President--Finance,  Secretary and/or one of its
other Vice- Presidents.

         9.5. "Registrable  Securities" means (i) the Common Stock issuable upon
conversion of the Series D Preferred Stock  underlying the Notes and exercise of
the  Warrants  purchased  pursuant  to Section  1.1 or (ii) any other  shares of
Common Stock now owned or hereafter acquired by Purchasers (whether Common Stock
owned  directly  or  underlying  convertible  securities  of the  Company).  For
purposes  of this  Agreement,  any shares of Common  Stock  issued  pursuant  to
Section 8.6 shall be deemed to be  Registrable  Securities and shall be included
in the Shelf Registration Statement contemplated by Section 8.1.

         9.6. "Securities" means the Notes, the Warrants and any Preferred Stock
or Common  Stock  underlying  the  foregoing  whether  issued at the  Closing or
thereafter.

         9.7.  "Securities  Act" means, as of any given time, the Securities Act
of 1933, as amended, or any similar federal law then in force.

         9.8.  "Securities  Exchange  Act"  means,  as of any  given  time,  the
Securities  Exchange Act of 1934, as amended, or any similar federal law then in
force.

         9.9.  "Securities and Exchange  Commission"  includes any  governmental
body or agency succeeding to the functions thereof.

         9.10.  "Subsidiary"  means any person,  corporation,  firm or entity at
least the majority of the equity  securities (or  equivalent  interest) of which
are, at the time as of which any determination is being made, owned of record or
beneficially by the Company,  directly or indirectly,  through any Subsidiary or
otherwise.

         10.1 Company Indemnities.  (a) The Company agrees to indemnify,  defend
and  hold  Purchasers  and  their  officers,  directors,   partners,  employees,
consultants and agents (the "Purchasers' Indemnitees") harmless from and against
any  liability,  obligation,  claim,  cost,  loss,  judgment,  damage or expense
(including  reasonable  legal fees and expenses)  (collectively,  "Liabilities")
incurred or suffered by any of Purchasers' Indemnitees as a result of or arising
out of or in  connection  with  the  Company's  breach  of  any  representation,
warranty, covenant or agreement of the Company contained herein.

         11. Miscellaneous.

         11.1.   Termination;   Survival  of  Representations,   Warranties  and
Covenants.   Except  as   otherwise   provided   for  in  this   Agreement   all
representations,   warranties,   covenants  and  agreements  contained  in  this
Agreement,  or in any document,  exhibit,  schedule or  certificate by any party
delivered in  connection  herewith  shall  survive the execution and delivery of
this  Agreement and the Closing Date and the  consummation  of the  transactions
contemplated  hereby,  regardless of any investigation  made by Purchasers or on
their behalf.

         11.2.  Expenses.  The  Company  shall  pay  all  its  own  expenses  in
connection with this Agreement and the  transactions  contemplated  herein.  The
Company agrees to pay promptly and save the  Partnership  and the Trust harmless
against  liability for the payment all expenses  incurred by the Company and the
Partnership and the Trust in connection with the preparation and consummation of
the  Agreement  and the  transactions  contemplated  herein,  including  but not
limited  to:  all  costs  and  expenses  under  Section  8,  including   without
limitation, the costs of preparing,  printing and filing with the Securities and
Exchange   Commission   the  Shelf   Registration   Statement  and   amendments,
post-effective  amendments,  and supplements  thereto;  preparing,  printing and
delivering   exhibits  thereto  and  copies  of  the   preliminary,   final  and
supplemental  prospectuses;  preparing,  


                                      -20-


<PAGE>

printing and delivering all selling documents,  including but not limited to the
subscription   agreement,   the   warrant   agreement   and  stock  and  warrant
certificates;  legal fees and  disbursements  of the Partnership and the Trusts'
counsel (which amount shall be offset against  payment of the purchase price for
legal  fees that have been  accrued up to such date and the  remainder  of which
shall be paid  within  30 days of  submission  of any  statements  therefor)  in
connection  with the  preparation  and  consummation  of this  Agreement and the
transactions  contemplated  herein,  including  the  legal  fees  and  costs  of
negotiating  and drafting  any  transaction  documents,  due  diligence  and any
necessary   regulatory  filings  (including,   without  limitation,   the  Shelf
Registration Statement, Forms 3, 4 and 5 and Schedule 13-D filings); the cost of
a total of two sets of bound closing  volumes for the  Partnership and the Trust
and  their  counsel;  and the cost of the  tombstone  advertisement  in the Wall
Street  Journal  (National  Edition)  pursuant  to  Section  7.23(c),  provided,
however,  that with respect to costs  incurred as a result of the actual  Bridge
Loan transaction (the "Bridge Loan Costs"),  the Company shall only be obligated
to reimburse the  Partnership  and the Trust in an amount not to exceed $35,000.
The "Bridge Loan Costs" shall not include any costs and expenses  under  Section
8, including  without  limitation,  the costs of preparing,  printing and filing
with the Securities and Exchange Commission the Shelf Registration Statement and
amendments,  post-effective  amendments,  and supplements thereto and preparing,
printing and delivering  exhibits thereto and copies of the  preliminary,  final
and supplemental prospectuses which such costs shall in all cases be paid by the
Company.  The  provisions of this Section shall survive any  termination of this
Agreement  in  all  instances,   including  without   limitation,   (i)  if  the
transactions contemplated by this Agreement have not been consummated or (ii) if
the transactions have been terminated by Purchasers for any reason.

         11.3.  Amendments and Waivers.  Except for the letter agreement between
the parties hereto and Paramount Capital,  Inc. dated as of January 28, 1997 and
the Operative  Documents,  this Agreement and all exhibits and schedules  hereto
set forth the entire  agreement  and  understanding  among the parties as to the
subject  matter  hereof  and  merges  and  supersedes  all  prior   discussions,
agreements and understandings of any and every nature among them. This Agreement
may be amended only by mutual  written  agreement of the Company and the holders
of a majority  of  principal  amount of the Notes,  and the Company may take any
action  herein  prohibited  or omit to take any  action  herein  required  to be
performed  by it,  and  any  breach  of any  covenant,  agreement,  warranty  or
representation  may be waived,  only if the  Company  has  obtained  the written
consent or waiver of the holders of a majority of principal  value of the Notes.
No course of dealing  between or among any persons  having any  interest in this
Agreement  will be deemed  effective to modify,  amend or discharge  any part of
this  Agreement or any rights or obligations of any person under or by reason of
this Agreement.

         11.4. Successors and Assigns. This Agreement may not be assigned by the
Company  except with the prior  written  consent of the holders of a majority of
principal value of the Notes.  This Agreement shall be binding upon and inure to
the  benefit  of the  Company  and its  permitted  successors  and  assigns  and
Purchasers and their successors and assigns. The provisions hereof which are for
Purchasers'  benefit as  purchasers or holders of the Notes and the Warrants are
also for the benefit of, and enforceable by, any subsequent holder of such Notes
and Warrants.

         11.5.  Notices.  All notices,  demands and other  communications  to be
given or delivered  under or by reason of the provisions of this Agreement shall
be in writing and shall be deemed to have been given  personally  or when mailed
by certified or registered mail,  return receipt  requested and postage prepaid,
and addressed to the addresses of the  respective  parties set forth below or to
such  changed  addresses  as such  parties  may have fixed by notice;  provided,
however,  that any  notice of change of  address  shall be  effective  only upon
receipt:


                           If to the Company:
                           Genta Incorporated.
                           3550 General Atomics Court
                           Building 9, 2nd Floor
                           San Diego, CA 92121
                           Attn: Thomas Adams


                                      -21-


<PAGE>

                           With a Copy to:
                           Pillsbury Madison & Sutro, LLP
                           235 Montgomery Street
                           San Francisco, CA 94104
                           Attn: Thomas E. Sparks, Jr.

                           If to the Partnership or the Trust:
                           Paramount Capital Asset Management, Inc.
                           787 Seventh Avenue
                           New York, NY 10019
                           Attn: David Walner

                           With a Copy to:
                           Kramer, Levin, Naftalis & Frankel
                           919 Third Avenue
                           New York, New York 10022
                           Attention: Ezra Levin

         11.6. Governing Law. The validity, performance, construction and effect
of this  Agreement  shall be governed by the  internal  laws of the State of New
York without giving effect to such State's principles of conflict of laws.

         11.7.  Counterparts.  This  Agreement  may be executed in any number of
counterparts  and,  notwithstanding  that any of the parties did not execute the
same counterpart,  each of such counterparts shall, for all purposes,  be deemed
an  original,  and all  such  counterparts  shall  constitute  one and the  same
instrument binding on all of the parties thereto.

         11.8.  Headings.  The headings of the Sections hereof are inserted as a
matter of  convenience  and for  reference  only and in no way define,  limit or
describe the scope of this Agreement or the meaning of any provision hereof.

         11.9.  Severability.  In the event that any provision of this Agreement
or the application of any provision hereof is declared to be illegal, invalid or
otherwise unenforceable by a court of competent  jurisdiction,  the remainder of
this Agreement  shall not be affected  except to the extent  necessary to delete
such illegal,  invalid or  unenforceable  provision  unless the  provision  held
invalid shall substantially  impair the benefit of the remaining portion of this
Agreement.

         11.10.  Freedom of Action.  (a) The Partnership and the Trust and their
affiliates shall not have any obligation to the Company not to (i) engage in the
same or similar  activities  or lines of  business  as the Company or develop or
market any  products,  services or  technologies  that does or may in the future
compete,  directly or indirectly,  with those of the Company, (ii) invest or own
any interest publicly or privately in, or develop a business  relationship with,
any  corporation,  partnership  or other person or entity engaged in the same or
similar  activities or lines or business as, or otherwise in  competition  with,
the  Company  or (iii) do  business  with any  client,  collaborator,  licensor,
consultant, vendor or customer of the Company. The Partnership and the Trust and
its officers, directors,  employees or former employees and affiliates shall not
have any  obligation,  or be  liable,  to the  Company  solely on account of the
conduct  described in the  preceding  sentence.  In the event that either of the
Partnership or the Trust and any officer, director,  employee or former employee
or affiliate thereof acquires knowledge of a potential  transaction,  agreement,
arrangement  or other matter which may be a corporate  opportunity  for both the
Partnership  and the Trust and the Company,  neither of the  Partnership and the
Trust nor their officers, directors, employees or former employees or affiliates
shall have any duty to communicate  or offer such  corporate  opportunity to the
Company  and  neither  of the  Partnership  and the Trust  nor  their  officers,
directors,  employees or former  employees or affiliates  shall be liable to the
Company for breach of any fiduciary duty, as a stockholder or otherwise,  solely
by reason of the fact that  Partnership  and the Trust or any of their officers,
directors,  employees or former  employees or affiliates  pursue or acquire such
corporate  opportunity for either of the  Partnership or the Trust,  direct such
corporate  opportunity  to another  person or entity or  communicate  or fail to
communicate such corporate opportunity or entity to the Company. As used in this
Section,  the  Partnership  and the  Trust  shall  mean  either  and both of the
Partnership  and the Trust and their  affiliates  (excluding  the  Company as an
affiliate of the Partnership and the Trust).


                                      -22-


<PAGE>

         (b) The  provisions of this Section 11.10 shall be  enforceable  to the
fullest extent permitted by law.

         11.11. Rights of Holders Inter Se. Each Holder of securities shall have
the absolute  right to exercise or refrain from  exercising  any right or rights
which  such  Holder  may  have by  reason  of  this  Agreement  or any  security
including,  without  limitation,  the  right to  consent  to the  waiver  of any
obligation  of the Company  under this  Agreement and to enter into an agreement
with the Company for the purpose of modifying  this  Agreement or any  agreement
effecting  such  modification,  and such Holder shall not incur any liability to
any other  Holder or  Holders  of  securities  with  respect  to  exercising  or
refraining from exercising any such right or rights.

         11.12.   Exculpation  Among  Purchasers  and  Holders.  Each  Purchaser
acknowledges and agrees that it is not relying upon any other Purchaser,  or any
officer, director, employee partner or affiliate of any such other Purchaser, in
making its investment or decision to invest in the Company or in monitoring such
investment.  Each Purchaser agrees that no Purchaser nor any controlling person,
officer,  director,  stockholder,  partner,  agent or employee of any  Purchaser
shall be liable for any action  heretofore  or hereafter  taken or omitted to be
taken  by any of them  relating  to or in  connection  with the  Company  or the
securities, or both.

         11.13.  Actions by  Purchasers.  Any actions  permitted  to be taken by
holders or Purchasers of Notes and/or  Warrants or the  Partnership or the Trust
and any consents required to be obtained from the same under this Agreement, may
be taken or given only by, in the case of consents or actions requiring approval
of the  Partnership or the Trust,  by the  Partnership or the Trust,  and in all
other cases,  only by holders of a majority of (i) in the case of the Notes, the
face amount of the principal and (ii) in the case of the Warrants, the number of
underlying   shares  of  Common  Stock,   and  if  such  holders  or  Purchasers
constituting  a majority  the  ("Majority  Holders") as set forth in (i) or (ii)
above or the  Partnership  or Trust take any action or grant any  consent,  such
action or consent  shall be deemed given or taken by all holders or  Purchasers'
who shall be bound by the decision or action  taken by the  Majority  Holders or
the  Partnership  or the Trust without any liability on the part of the Majority
Holders or the  Partnership  or the Trust to any other holder or  Purchasers  of
securities hereto.

         11.14.  Secured Party. The Purchasers hereby acknowledge and agree that
Paramount  Capital,  Inc.  shall act as the secured party (the "Secured  Party")
under and for all purposes of the Security  Agreement.  Without giving notice to
any holder of Notes, the Secured Party shall have full and irrevocable authority
on behalf of the undersigned and all other holders of Notes, with respect to the
Security Agreement,  Financing  Statements,  to (i) deal with the Company,  (ii)
accept and give  notices and other  communications,  (iii)  settle any  disputes
relating to the terms thereof,  (iv) waive any  conditions,  (v) modify or amend
the Security Agreement or the Subordination  Agreement (but not the Notes), (vi)
execute any  instrument  or document  that the Secured  Party may  determine  is
necessary  or  desirable  in the  exercise of its  authority  under this Section
11.14,  and  (vii) act in  connection  with all other  matters  relating  to the
Security  Agreement.  The Secured  Party shall be authorized to act on behalf of
the Purchasers as provided in the Security  Agreement,  and the Company shall be
entitled to act and rely upon any request,  notice, consent, waiver or agreement
given on behalf  of the  undersigned  when the same  shall  have  been  given by
Paramount  Capital,  Inc. on such behalf  pursuant to the terms of such Security
Agreement or this Agreement.  Paramount  Capital,  Inc. may act in reliance upon
the advice of counsel in reference to any matter  relating  hereto and shall not
be liable for any acts or omissions of any kind.

         11.15 Consent to Jurisdiction.  The parties hereto irrevocably  consent
to the  jurisdiction  of the courts of the State of New York and of any  federal
court located in such State in connection with any action or proceeding  arising
out of or relating to this  Agreement,  any  document  or  instrument  delivered
pursuant to, in connection  with or  simultaneously  with this  Agreement,  or a
breach of this Agreement or any such document or instrument.  In any such action
or  proceeding,  each party  hereto  waives  personal  service  of any  summons,
complaint  or other  process  and agrees  that  service  thereof  may be made in
accordance with Section 11.15.  Within 30 days after such service, or such other
time as may be mutually  agreed upon in writing by the attorneys for the parties
to such action or  proceeding,  the party so served  shall appear or answer such
summons, complaint or other process.


                                      -23-


<PAGE>

         IN WITNESS WHEREOF,  the parties hereto have executed this Agreement as
of the day and year first above written.


                               GENTA INCORPORATED.


                               By: /s/ Thomas H. Adams
                                   ---------------------------
                                   Name: Dr. Thomas H. Adams
                                   Title:  President and Chief
                                           Executive Officer

                               THE ARIES FUND, A CAYMAN
                               ISLAND TRUST

                               By:  its Investment Manager,
                               PARAMOUNT CAPITAL ASSET
                               MANAGEMENT, INC.


                               By: /s/Lindsay A. Rosenwald
                                   ---------------------------------
                                   Name:  Lindsay A. Rosenwald, M.D.
                                   Title:  President


                               THE ARIES DOMESTIC FUND, L.P.


                               By:  its General Partner, PARAMOUNT
                               CAPITAL ASSET MANAGEMENT, INC..


                               By: /s/Lindsay A. Rosenwald
                                   ---------------------------------
                                   Name:  Lindsay A. Rosenwald, M.D.
                                   Title:  President


                                      -24-

                                                              January 28, 1997




VIA FACSIMILE:
(212) 554-4490

Lindsay A. Rosenwald, M.D.
Paramount Capital Asset Management, Inc.
787 Seventh Avenue
New York, NY 10019

Dear Lindsay:

                  This letter confirms the agreement between Genta  Incorporated
(the  "Company")  and  the  Aries  Domestic  Fund,  L.P.  and  The  Aries  Trust
(collectively, the "Purchasers") as follows:

                  WHEREAS, as of the date hereof, the Company and the Purchasers
         entered into,  executed and delivered various agreements (the "Purchase
         Documents") pursuant to which the Purchasers,  subject to a Closing (as
         defined  in the Note and  Warrant  Purchase  Agreement),  will  make an
         investment (the "Transaction") in the Company of $3,000,000 in the form
         of Senior Secured Convertible Bridge Notes;

                  WHEREAS,   the  Purchase   Documents   are  comprised  of  the
         following, (i) Note and Warrant Purchase Agreement, (ii) Senior Secured
         Convertible  Bridge Note,  (iii) Class A Bridge  Warrant,  (iv) Class B
         Bridge Warrant,  (v) Security Agreement,  (vi) Letter of Intent,  (vii)
         Certificate  of  Designations  for Series D Preferred  Stock and (viii)
         Security Agreement;

                  WHEREAS,  the Purchase  Documents  have been  executed but the
         Purchasers  have yet to be provided with the final executed  opinion of
         Pillsbury Madison & Sutro LLP (the "Pillsbury  Madison Opinion") or the
         final  version  of the  schedules  (the  "Schedules")  to the  Purchase
         Documents;

                  WHEREAS, the Company has determined that in light of its
         financial situation, it requires funding immediately;

In light of the foregoing the Company and Purchasers agree as follows:

                  (1) The parties  acknowledge  that all the Purchase  Documents
                  have been signed and that  Purchasers  have yet to receive the
                  final executed  Pillsbury  Madison  Opinion and the Schedules,
                  which such documents shall be satisfactory in


<PAGE>


Lindsay A. Rosenwald, M.D.
January 28, 1997
Page 2



                  form and substance to Purchasers in their sole
                  discretion.

                  (2)  Purchasers  agree to  advance  to the  Company  under and
                  subject to the terms of the  Purchase  Documents,  two hundred
                  and fifty thousand  dollars  ($250,000) to provide the Company
                  with immediate  operating capital to be expended in accordance
                  with the attached schedule.

                  (3)  The  Company  agrees  that  if it does  not  deliver  the
                  Schedules  and the  Pillsbury  Madison  Opinion,  in form  and
                  substance satisfactory to Purchasers in their sole discretion,
                  by February 7, it will immediately refund $250,000 (or if less
                  than $250,000 remains from the initial  $250,000,  such lesser
                  amount as remains) to the Purchasers and the Purchasers  shall
                  have an  unconditional  right to rescind their purchase of the
                  $250,000 worth of Senior Secured Convertible Bridge Notes.

                  (4)  Purchasers  agree that upon receipt of the  Schedules and
                  Pillsbury Madison Opinion,  subject to the satisfaction of all
                  of the  conditions  to  Purchasers'  closing  contained in the
                  Purchase  Documents  (which   satisfaction   Purchasers  shall
                  determine in their sole  discretion),  and upon the occurrence
                  of a Closing,  they will provide to the Company the  remaining
                  $2,750,000 of debt financing in exchange for the securities of
                  the Company all as provided  for and set forth in, and subject
                  to the terms of, the Purchase Documents.

                  (5) The Company  agrees that it may not  terminate  any of the
                  Purchase  Documents  and is  obligated  to  proceed  with  the
                  Transaction  as set  forth in the  Purchase  Documents  unless
                  Purchasers terminate such agreements or indicate in writing to
                  the  Company  that  they  have  determined  not to  close  the
                  Transaction.


<PAGE>


Lindsay A. Rosenwald, M.D.
January 28, 1997
Page 3



If the foregoing conforms to your understanding, please sign, date and return to
us the enclosed copy of this letter.

                                       Very truly yours,

                                       GENTA INCORPORATED.

                                       By: /s/Thomas Adams
                                           ---------------
                                           Thomas Adams
                                           President and Chief Executive Officer

The foregoing is in conformity with our understanding:

ARIES DOMESTIC FUND, L.P.

By: /s/Lindsay A. Rosenwald
    ---------------------------
    Lindsay A. Rosenwald, M.D.
    President, Paramount Capital Asset Management, Inc.
    General Partner of Aries Domestic Fund, L.P.

THE ARIES TRUST

By: /s/Lindsay A. Rosenwald
    ---------------------------
    Lindsay A. Rosenwald, M.D.
    President, Paramount Capital Asset Management, Inc
    Investment Adviser to the Aries Trust


<PAGE>


Lindsay A. Rosenwald, M.D.
January 28, 1997
Page 4



                                               Expenditure Schedule
                                               --------------------


Payroll                                              $114,000*
Pillsbury Madison                                    $ 72,000
D&O Insurance                                        $ 39,000
Medical, Dental, Disability                          $ 25,000
                                                     --------

Total                                                $250,000
                                                     --------




*Amounts attributable to 401(k) to be discussed with Paramount
Capital Asset Management



                                                                    EXHIBIT 10.3

THIS NOTE IS NOT  TRANSFERABLE  WITHOUT  THE  EXPRESS  WRITTEN  CONSENT OF GENTA
INCORPORATED,  (THE "COMPANY"). THE SECURITIES REPRESENTED BY THIS NOTE HAVE NOT
BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF  1933 OR ANY  APPLICABLE  STATE
SECURITIES LAWS, AND MAY NOT BE SOLD,  OFFERED FOR SALE, PLEDGED OR HYPOTHECATED
OR OTHERWISE  TRANSFERRED IN THE ABSENCE OF A  REGISTRATION  STATEMENT IN EFFECT
WITH RESPECT TO THE  SECURITIES  UNDER SUCH ACT OR AN EXEMPTION  THEREFROM.  ANY
SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE STATE SECURITIES LAWS.


                               GENTA INCORPORATED

                                                                          No.B-1
                     SENIOR SECURED CONVERTIBLE BRIDGE NOTE

$1,050,000                                                    New York, New York
                                                              January 28, 1997

         Genta Incorporated, a Delaware corporation,  (the "Company"), for value
received,  hereby promises to pay to THE ARIES DOMESTIC FUND, LP (the "Holder"),
or registered  assigns,  the principal sum of ONE MILLION FIFTY THOUSAND DOLLARS
($1,050,000),  with  interest  from the date of issuance of this Senior  Secured
Convertible  Bridge  Note on the  unpaid  principal  balance  at a rate equal to
twelve percent (12%) per annum, on the earlier of (a) June 30, 1997 and (b) five
(5) business days following the  completion of any equity  offering or series of
equity  offerings  with gross  proceeds in excess of $2,500,000  (the  "Maturity
Date").  Payment  shall be made at such place as  designated  by the Holder upon
surrender of this Senior Secured  Convertible  Bridge Note, and shall be in such
coin or currency of the United States of America as at the time of payment shall
be legal tender for the payment of public and private  debts.  Interest shall be
computed on the basis of a 360-day  year of twelve  30-day  months.  This Senior
Secured  Convertible  Bridge  Note is one of a duly  authorized  issue  of Genta
Incorporated  12% Senior  Convertible  Bridge  Notes in an  aggregate  principal
amount of $3,000,000 (individually a "Note" and collectively the "Notes") issued
pursuant to a Note and Warrant Purchase  Agreement of even date herewith between
the  Company  and the Holder  (the  "Purchase  Agreement").  The Senior  Secured
Convertible  Bridge  Notes  shall be  senior to all  other  indebtedness  of the
Company ("Other  Indebtedness") and all Other Indebtedness shall be subordinated
to the Senior  Bridge  Notes.  These Notes are secured  pursuant to the Security
Agreement  dated as of January 28, 1997 by and  between the  Company,  Paramount
Capital, Inc. and the Purchasers.

SECTION 1. PREPAYMENT.

         This Note (including  interest accrued on the principal  hereof) may be
prepaid by the Company, at any time without penalty or premium provided that the
Company  shall  provide  the  holders  of the Notes  with at least 30 days prior
written notice of prepayment,  and prior to such prepayment,  the holders of the
Notes shall have the  opportunity to exercise their optional  conversion  rights
pursuant to Section 2 hereof.

SECTION 2. OPTIONAL CONVERSION

         (a) Right of Conversion. (i) Immediately,  or, (ii) if the rules of the
Nasdaq National  Market or any other law or regulation,  require the approval of
the shareholders of the Company to permit convertibility of the Notes, then upon
the receipt of such approvals,  the Notes shall be  convertible,  in whole or in
part, at the option of the holder thereof and upon notice to the  Corporation as
set  forth in  paragraph  2(b)  below,  into the  number  of  shares of Series D
Preferred Stock of the Company (the  "Preferred  Stock") equal to the Conversion
Amount  divided by the then current  Conversion  Price (as defined  below).  The
Conversion  Amount shall be the Liquidation  Amount, or in the case of a partial
conversion,  such lesser  amount as  designated by the  converting  holder.  The
Liquidation  Amount shall be the aggregate  principal value of the Notes held by
such Holder plus any accrued and unpaid  interest.  The  Conversion  Price shall
initially be $5.00,  subject to adjustment as provided  below,  representing  an
initial  conversion  rate  (subject to  adjustment)  of 2000 shares of Preferred
Stock per $10,000 of Conversion Amount.


                                       -1-


<PAGE>

         (b) Conversion Procedures. Any holder of Notes desiring to convert such
Notes into  Preferred  Stock  shall  surrender  the Notes at the  offices of the
Company,  which Notes shall be accompanied by irrevocable  written notice to the
Corporation  that the holder elects so to convert such Notes and  specifying the
name or names (with address) in which a certificate or  certificates  evidencing
shares of Preferred Stock are to be issued. The Corporation will make a notation
of the date that a notice of conversion is received,  which date shall be deemed
to be the date of receipt for purposes hereof.

         The Corporation shall deliver to the holder converting the Notes, or to
the nominee or nominees of such person,  certificates  evidencing  the number of
full  shares of  Preferred  Stock to which  such  person  shall be  entitled  as
aforesaid,  together  with a cash  adjustment  of any  fraction  of a  share  as
hereinafter  provided.  Subject to the following  provisions of this  paragraph,
such  conversion  shall  be  deemed  to have  been  made as of the  date of such
surrender  of the Notes and the  person  or  persons  entitled  to  receive  the
Preferred Stock  deliverable  upon conversion of such Notes shall be treated for
all  purposes as the record  holder or holders of such  Preferred  Stock on such
date; provided,  however,  that the Corporation shall not be required to convert
any Notes while the stock transfer books of the  Corporation  are closed for any
purpose,  but the surrender of Notes for conversion during any period while such
books are so closed shall become  effective for conversion  immediately upon the
reopening  of such books as if the  surrender  had been made on the date of such
reopening,  and the conversion shall be at the conversion rate in effect on such
date.

         All notices of conversion shall be irrevocable; provided, however, that
if the  Corporation  has sent  notice of an event  pursuant  to  paragraph  2(e)
hereof,  a holder  of Notes  may,  at its  election,  provide  in its  notice of
conversion  that  the  conversion  of its  Notes  shall be  contingent  upon the
occurrence  of the record date or  effectiveness  of such event (as specified by
such  holder),  provided  that such  notice of  conversion  is  received  by the
Corporation prior to such record date or effective date, as the case may be.

         (c) Protection From Dilution.  (i) If, at any time or from time to time
after the date of this  Note,  the  Company  shall  issue or  distribute  to the
holders of shares of Preferred  Stock  evidence of its  indebtedness,  any other
securities  of the Company or any cash,  property or other  assets  (excluding a
subdivision,  combination  or  reclassification,  or  dividend  or  distribution
payable  solely to  holders of  Preferred  Stock in shares of  Preferred  Stock,
referred to in Subsection  (c)(ii),  and also  excluding  cash dividends or cash
distributions  paid out of net profits  legally  available  therefor in the full
amount  thereof  (any such  non-excluded  event being  herein  called a "SPECIAL
DIVIDEND"), the Conversion Price shall be adjusted by multiplying the Conversion
Price then in effect by a  fraction,  the  numerator  of which shall be the then
Current  Market Price Per Share of Preferred  Stock in effect on the record date
of such issuance or  distribution  less the fair market value (as  determined in
good faith by the Company's Board of Directors) of the evidence of indebtedness,
cash,  securities  or property,  or other assets issued or  distributed  in such
Special Dividend  applicable to one share of Preferred Stock and the denominator
of which shall be the then Current Market Price Per Share of Preferred  Stock in
effect on the record date of such issuance or  distribution.  An adjustment made
pursuant to this Subsection 2(a) shall become  effective  immediately  after the
record date of any such Special  Dividend.  The then  "CURRENT  MARKET PRICE PER
SHARE OF PREFERRED  STOCK" shall equal the then Current Market Price  multiplied
by the then effective  "conversion rate" (as defined and used in the Certificate
of Designation for the Series D Preferred Stock).

The then Current  Market Price per share (the "CURRENT  MARKET  PRICE") shall be
deemed to be the last sale price of the Common Stock on the trading day prior to
such date or, in case no such reported sales take place on such day, the average
of the last  reported  bid and asked  prices of the Common Stock on such day, in
either case on the principal  national  securities  exchange on which the Common
Stock is admitted to trading or listed,  or if not listed or admitted to trading
on any such exchange,  the representative  closing bid price of the Common Stock
as reported by the National  Association of Securities  Dealers,  Inc. Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined in good faith by the Board of Directors.

         (ii) In case the Company  shall  hereafter (i) pay a dividend or make a
distribution on its capital stock in shares of Preferred  Stock,  (ii) subdivide
its outstanding shares of Preferred Stock into a greater number of shares, (iii)
combine  its  outstanding  shares of  Preferred  Stock into a smaller  number of
shares or (iv) issue by  


                                       -2-


<PAGE>

reclassification  of its  Preferred  Stock any  shares of  capital  stock of the
Company  (other  than the  Conversion  Shares),  the  Conversion  Price shall be
proportionately  adjusted so that the Notes shall be  convertible  into a number
and kind of  securities  which the holders  would have been  entitled to receive
after any such event had they converted the Notes immediately prior thereto.  An
adjustment  made pursuant to this  Subsection  2(c)(ii)  shall become  effective
immediately  after the record date in the case of a dividend or distribution and
shall become  effective  immediately  after the effective  date in the case of a
subdivision, combination or reclassification.

         (iii) Except as provided in Subsections (c)(i) and (c)(iv), in case the
Company  shall  hereafter  issue or sell any  Preferred  Stock,  any  securities
convertible into Preferred  Stock,  any rights,  options or warrants to purchase
Preferred Stock or any securities convertible into Preferred Stock, in each case
for a price per share or  entitling  the holders  thereof to purchase  Preferred
Stock at a price per share (determined by dividing (i) the total amount, if any,
received or receivable by the Company in  consideration  of the issuance or sale
of such securities plus the total consideration,  if any, payable to the Company
upon  exercise or  conversion  thereof (the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of  Preferred  Stock  issuable  upon  exercise  or
conversion of such securities) which is less than either the then Current Market
Price Per Share of  Preferred  Stock in effect on the date of such  issuance  or
sale or the Conversion  Price,  the Conversion Price shall be adjusted as of the
date of such issuance or sale by multiplying the Conversion Price then in effect
by a fraction,  the numerator of which shall be (x) the sum of (A) the number of
shares of Preferred  Stock  outstanding  on the record date of such  issuance or
sale plus (B) the Total  Consideration  divided by the Current  Market Price Per
Share of Preferred Stock or the current Conversion Price,  whichever is greater,
and the  denominator  of which  shall be (y) the  number of shares of  Preferred
Stock  outstanding  on the record date of such issuance or sale plus the maximum
number of additional  shares of Preferred  Stock  issued,  sold or issuable upon
exercise or conversion of such securities.

         (iv) In case of any capital reorganization or reclassification,  or any
consolidation  or merger to which the  Company is a party other than a merger or
consolidation in which the Company is the continuing corporation,  or in case of
any sale or  conveyance  to another  entity of the property of the Company as an
entirety  or  substantially  as a  entirety,  or in the  case  of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Note shall have the right  thereafter  to receive on the  conversion  of
this Note the kind and amount of  securities,  cash or other  property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had  this  Note  been  converted  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 2 with respect to the rights and  interests  thereafter of
the Holder of this Note to the end that the provisions set forth in this Section
2  shall  thereafter  correspondingly  be  made  applicable,  as  nearly  as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  Note.  The above  provisions  of this
Subsection   (c)(iv)  shall  similarly  apply  to  successive   reorganizations,
reclassifications,   consolidations,  mergers,  statutory  exchanges,  sales  or
conveyances.  The  Company  shall  require  the issuer of any shares of stock or
other securities or property thereafter deliverable on the exercise of this Note
to be  responsible  for all of the  agreements  and  obligations  of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the Notes not less than
30 days prior to such event. A sale of all or substantially all of the assets of
the Company for a  consideration  consisting  primarily of  securities  shall be
deemed a consolidation or merger for the foregoing purposes.

         (v) In case any event shall occur as to which the other  provisions  of
this Section 2 are not strictly  applicable  but as to which the failure to make
any adjustment  would not fairly protect the  conversion  rights  represented by
this Note in accordance with the essential intent and principles hereof then, in
each such case,  the Holders of Notes may appoint a firm of  independent  public
accountants  of  recognized  national  standing  reasonably  acceptable  to  the
Company, which shall give their opinion as to the adjustment, if any, on a basis
consistent  with  the  essential  intent  and  principles   established  herein,
necessary to preserve the conversion rights.  Upon receipt of such opinion,  the
Company will  promptly  mail a copy thereof to the Holder of this Note and shall
make  the  adjustments   described  therein.  The  fees  and  expenses  of  such
independent public accountants shall be borne by the Company.

         
                                       -3-


<PAGE>

(vi) For purposes of the anti-dilution protection contained in this Section (c),
at all times  following  the  conversion  of all shares of Preferred  Stock into
shares of Common  Stock,  the term  Preferred  Stock  shall be read to be Common
Stock, context permitting, so that the anti-dilution provisions will continue to
protect the conversion  rights  represented by this Note after the conversion of
all the Preferred  Stock into the Common Stock in accordance  with the essential
intent and principles of this Section 3 (it being  understood that prior to such
conversion,  the anti-dilution provisions of the Preferred Stock underlying this
Note shall be applicable to any dilutive events with respect to the Common Stock
and protect the Holder from dilution of the Common Stock).

         (d) Reservation of Shares;  Transfer Taxes;  Etc. The Corporation shall
at all times  reserve and keep  available,  out of its  authorized  and unissued
shares of Preferred Stock, solely for the purpose of effecting the conversion of
the Notes,  such  number of shares of its  Preferred  Stock  free of  preemptive
rights as shall be sufficient to effect the conversion of all Notes from time to
time outstanding.  The Corporation shall use its best efforts from time to time,
in accordance with the laws of the State of Delaware, to increase the authorized
number  of  shares  of  Preferred  Stock if at any time the  number of shares of
Preferred Stock not outstanding shall not be sufficient to permit the conversion
of all the then-outstanding Notes.

         The Corporation  shall pay any and all issue or other taxes that may be
payable in  respect of any issue or  delivery  of shares of  Preferred  Stock on
conversion of the Notes. The Corporation shall not, however,  be required to pay
any tax which may be payable in respect of any transfer involved in the issue or
delivery of Preferred Stock (or other securities or assets) in a name other than
that in which the  Notes so  converted  were  registered,  and no such  issue or
delivery  shall be made  unless and until the person  requesting  such issue has
paid to the  Corporation  the  amount  of such  tax or has  established,  to the
satisfaction of the Corporation, that such tax has been paid.

         (e) Prior Notice of Certain Events. In case:

               (i) the  Corporation  shall  declare any  dividend  (or any other
               distribution); or

               (ii) the Corporation  shall authorize the granting to the holders
               of  Preferred  Stock of rights or  warrants to  subscribe  for or
               purchase  any shares of stock of any class or of any other rights
               or warrants; or

               (iii) of any  reclassification  of Preferred  Stock (other than a
               subdivision or combination of the outstanding Preferred Stock, or
               a change in par value, or from par value to no par value, or from
               no par value to par value); or

               (iv) of any consolidation or merger to which the Corporation is a
               party  and  for  which  approval  of  any   stockholders  of  the
               Corporation shall be required,  or of the sale or transfer of all
               or  substantially  all of the assets of the Corporation or of any
               compulsory   share  exchange   whereby  the  Preferred  Stock  is
               converted into other securities, cash or other property; or

               (v) of the voluntary or involuntary  dissolution,  liquidation or
               winding up of the Corporation;

then the Corporation  shall cause to be mailed to the holders of Notes, at their
last addresses as they shall appear upon the books of the Corporation,  at least
20 days prior to the  applicable  record date  hereinafter  specified,  a notice
stating  (x) the date on which a record (if any) is to be taken for the  purpose
of such dividend, distribution or granting of rights or warrants or, if a record
is not to be  taken,  the date as of which the  holders  of  Preferred  Stock of
record to be entitled to such dividend, distribution,  rights or warrants are to
be determined and a description of the cash,  securities or other property to be
received by such holders upon such dividend,  distribution or granting of rights
or  warrants  or (y) the date on  which  such  reclassification,  consolidation,
merger, sale, transfer, share exchange,  dissolution,  liquidation or winding up
or other liquidation event is expected to become effective, the date as of which
it is expected  that holders of  Preferred  Stock of record shall be entitled to
exchange  their  shares of  Preferred  Stock for  securities  or other  property
deliverable upon such exchange, dissolution,  liquidation or winding up or other
liquidation event and the consideration, including securities or other property,
to be received by such holders upon such exchange;  provided,  however,  that no
failure to mail such


                                       -4-


<PAGE>

notice or any defect therein or in the mailing thereof shall affect the validity
of the corporate action required to be specified in such notice.

         (f) Other Changes in Conversion Rate. The Corporation from time to time
may  increase  the  Conversion  Rate by any amount for any period of time if the
period is at least 20 days and if the increase is irrevocable during the period.
Whenever the  Conversion  Rate is so increased,  the  Corporation  shall mail to
holders of record of Notes a notice of the  increase at least 15 days before the
date the increased Conversion Rate takes effect, and such notice shall state the
increased Conversion Rate and the period it will be in effect.

         The  Corporation  may make such  increases in the  Conversion  Rate, in
addition  to  those  required  or  allowed  by this  paragraph  4, as  shall  be
determined by it, as evidenced by a resolution of the Board of Directors,  to be
advisable  in order to avoid or  diminish  any  income  tax to holders of Common
Stock resulting from any dividend or distribution of stock or issuance of rights
or warrants to purchase or subscribe for stock or from any event treated as such
for income tax purposes.

SECTION 3. DEFAULT CONVERSION.

         (a) If this Note and all accrued  interest  shall not have been paid in
full on or  before  the  Maturity  Date or upon  the  occurrence  of an Event of
Default (as defined in Section 7 hereof),  the Holder  shall have the right (the
"Default  Conversion  Right"),  in addition to any other available  remedies set
forth in Section 8 hereof or at law or in equity, to convert up to the lesser of
(i) the  then  outstanding  principal  amount  of this  Note or (ii)  10% of the
original  principal  amount of this  Note,  into the  number of shares of Common
Stock of the Company  ("Common  Stock"),  equal to the amount  converted  by the
Noteholder upon such Event of Default (the "Default  Conversion Amount") divided
by $.001 (the "Default  Conversion Price").  Upon conversion,  the Company shall
pay all accrued and unpaid interest on the Default Conversion Amount.

         (b) To exercise the Default  Conversion Right, the Holder, on or before
the 60th day after the  Maturity  Date,  but before  payment in full of the then
outstanding  principal  and  interest  under  this  Note,  shall  deliver to the
Company,  at its office at as set forth in section 11, or at such other place as
is  designated  in writing by the Company,  a notice (the  "Conversion  Notice")
stating that the Holder is exercising the Default  Conversion Right, the Default
Conversion  Amount  and the  name or  names  in  which  the  Holder  wishes  the
certificates for shares of Common Stock to be issued.

         (c) To the extent  permitted by  applicable  law,  upon exercise of the
Default  Conversion Right, the Holder shall be deemed to be the holder of record
of the shares of Common  Stock  issuable  upon such  exercise  (the  "Conversion
Shares"),  notwithstanding  that the transfer books of the Company shall then be
closed or certificates  representing  such Conversion Shares shall not then have
been actually  delivered to the Holder.  As soon as practicable and in any event
within five (5) days after exercise of the Default Conversion Right, the Company
shall issue and deliver to the Holder a certificate or  certificates  evidencing
the  Conversion  Shares  registered  in the name of the Holder or its  designee,
provided that the Company may require the holder,  by notice given to the Holder
promptly after receipt of the Conversion  Notice, as a condition to the delivery
of such certificate or certificates, to present this Note to the Company for the
placement  hereon of a legend  indicating that the Default  Conversion Right has
been  exercised to the extent of the Default  Conversion  Amount,  and this Note
(unless thereby paid in full) shall be immediately returned to the Holder.

         (d) The issuance of any shares or other securities upon the exercise of
the  Default  Conversion  Right,  and the  delivery  of  certificates  or  other
instruments representing such shares or other securities,  shall be made without
charge to the  Holder for any tax or other  charge in respect of such  issuance.
The Company shall not, however,  be required to pay any tax which may be payable
in respect of any transfer involved in the issue and delivery of any certificate
in a name other than that of the Holder and the Company shall not be required to
issue or  deliver  any such  certificate  unless and until the person or persons
requesting  the issue  thereof shall have paid to the Company the amount of such
tax or shall have  established to the  satisfaction of the Company that such tax
has been paid.

         (e) The Holder  shall not have,  solely on account of such  status as a
Holder of this Note, any rights of a stockholder  of the Company,  either at law
or in  equity,  or any  notice  of  meetings  of  stockholders  or of any  other
proceedings of the Company except as provided in this Note.


                                       -5-
<PAGE>

         (f) The Company shall at all times following the Issuance Date, reserve
and keep available out of its  authorized  and unissued  shares of Common Stock,
solely for the purpose of providing  for the exercise of the Default  Conversion
Right,  such number of shares of Common  Stock as shall,  from time to time,  be
sufficient for the exercise of the Default Conversion Right in full. The Company
covenants  that all shares of Common Stock issuable upon exercise of the Default
Conversion Right shall be validly issued, fully paid and nonassessable.

         (g) The  anti-dilution  protections  set forth in Section  2(c)  hereof
shall apply as well to the Default  Conversion  Right and the  adjustment of the
Default Conversion Price hereunder, provided, however, that for purposes of such
application  all  appropriate  references  to  Preferred  Stock shall be read as
references to Common Stock and all references to the  Conversion  Price shall be
read as references to the Default  Conversion  Price,  so as to give the Default
Conversion  Rights,  as  nearly  as  practicable,  the  anti-dilution  and other
protections provided for in section 2(c) with respect to the Optional Conversion
Right.

SECTION 4. FRACTIONAL SHARES.

         (a) The Company  shall not be required to issue  fractions of shares of
Common  Stock or other  capital  stock of the Company  upon the  exercise of the
Optional  and  Default  Conversion  Right.  If any  fraction of a share would be
issuable  on any  exercise  of the  Optional  or  Default  Conversion  Right (or
specified  portions  thereof),  the Company shall  purchase such fraction for an
amount in cash equal to the same  fraction of the  closing  price for the Common
Stock on the  trading  date  immediately  preceding  the date of exercise of the
Optional or Default Conversion Right.


SECTION 5. AFFIRMATIVE COVENANTS OF THE COMPANY.

         The Company covenants and agrees that until the payment in full of this
Note, the Company shall:

         (a) Existence; Business. (i) Preserve, renew and keep in full force and
effect its legal existence and (ii) obtain, preserve,  renew, extend and keep in
full force and effect the licenses, permits, authorizations, patents, trademarks
and trade names material to its business.

         (b) Use of Proceeds. Use the proceeds of the Notes of this issue solely
as set forth in Section 7.7 of the Note and Warrant Purchase  Agreement  between
the  Company  and  various  purchasers  dated  the date  hereof  (the  "Purchase
Agreement")

         (c)  Reports.  Furnish  to the  Holder,  at the time  furnished  to the
Company's   stockholders,   reports   furnished   generally  to  the   Company's
stockholders, and copies of Current Reports on Form 8-K.

         (d) Notice of Events of Default.  Furnish to the Holder prompt  written
notice of any Event of  Default,  specifying  the nature and extent  thereof and
corrective action, if any, proposed to be taken with respect thereto.

         (e) Authorization of Stock Issuable Upon Conversion.  No later than the
Maturity  Date,  authorize  and  reserve a  sufficient  number of its shares for
exercise of the Default Conversion Right.


SECTION 6. NEGATIVE COVENANTS OF THE COMPANY.

         The Company covenants and agrees with the Holder that until the payment
in full of this Note, the Company shall not:

         (a)  Indebtedness.  Incur,  create,  assume  or  permit  to  exist  any
indebtedness except (i) indebtedness represented by the Notes, (ii) indebtedness
which by its terms is  subordinated  to the Notes in an amount less than $25,000
in the  aggregate  (iii)  indebtedness  in an amount  less than  fifty  thousand
dollars ($50,000) incurred in the ordinary course of business, and (iv)
indebtedness  for borrowed  money  existing on the date hereof and  disclosed in
writing to the Holder on or prior to the date  hereof,  but not any  extensions,
renewals or replacements of such indebtedness;


                                       -6-


<PAGE>

         (b)  Liens.  Create,  incur,  assume or permit to exist any lien on any
property or assets (including stock or other securities of any person) now owned
or hereafter acquired by the Company,  except (i) liens for taxes not yet due or
which  are  being   contested  by  appropriate   proceedings;   (ii)  carriers',
warehousemen's,  mechanic's,  materialmen's,  repairmen's  or other  like  liens
arising in the ordinary course of business and securing obligations that are not
due or which are being  contested;  or (iii) liens of attachments,  judgments or
awards against the Company (X) which could not reasonably be expected to have an
adverse material effect on the Company or (Y) with respect to which an appeal or
proceeding  for review shall be pending or a stay of  execution  shall have been
obtained,  or  which  are  otherwise  being  contested  in  good  faith  and  by
appropriate  proceedings,  or (iv) purchase  money liens,  equipment  leases and
financings incurred in the ordinary course of business.

         (c) Sale  and  Lease-Back  Transactions.  Enter  into any  arrangement,
directly or  indirectly,  with any person  whereby it shall sell or transfer any
property, real or personal, used or useful in its business, whether now owned or
hereafter acquired, and thereafter rent (including intellectual property), lease
or  license  such  property  or  other  property  which  it  intends  to use for
substantially  the same  purpose  or  purposes  as the  property  being  sold or
transferred.

         (d) Mergers,  Consolidations,  Sales of Assets and Acquisitions.  Merge
into or consolidate  with any other person,  or permit any other person to merge
into or consolidate with it, or sell,  transfer,  lease or otherwise  dispose of
(in one transaction or in a series of transactions) all or a substantial part of
its assets  (whether  now owned or hereafter  acquired)  or  purchase,  lease or
otherwise  acquire (in one  transaction  or a series of  transactions)  all or a
substantial part of the assets of any other person.

         (e)  Dividends  and   Distributions.   Declare  or  pay,   directly  or
indirectly, any dividend or make any other distribution (by reduction of capital
or otherwise),  whether in cash, property,  securities or a combination thereof,
with  respect to any  shares of its  capital  stock or  directly  or  indirectly
redeem, purchase,  retire or otherwise acquire for value any shares of any class
of its  capital  stock or set aside any amount for any such  purpose,  except as
permitted by Section 7.15 of the Note and Warrant Agreement.

         (f)  No   Impairment.   By   amendment   of  its   charter  or  through
reorganization,  consolidation, merger, dissolution, sale of assets or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the  terms of this  Note,  but will at all  times in good  faith  assist  in the
carrying  out of all such terms and in the  taking of all such  action as may be
necessary  or  appropriate  in order to protect the rights of the Holder of this
Note against impairment.


SECTION 7. EVENTS OF DEFAULT DEFINED.

         The following shall each constitute an "Event of Default" hereunder:

         (a) the failure of the Company to make any payment of  principal  of or
interest on this Note when due and payable;

         (b) the failure of the  Company to observe or perform  any  covenant in
this Note or in the Purchase  Agreement,  and such failure shall have  continued
unremedied for a period of five (5) days;

         (c) if the Company shall:

               (1) admit in writing its inability to pay its debts  generally as
               they become due,

               (2) file a petition in bankruptcy or a petition to take advantage
               of any insolvency act,

               (3) make an assignment for the benefit of its creditors,

               (4) consent to the  appointment of a receiver of itself or of the
               whole or any substantial part of its property,


                                       -7-


<PAGE>

               (5) on a petition in bankruptcy  filed against,  be adjudicated a
               bankrupt, or

               (6)  file  a  petition  or  answer  seeking   reorganization   or
               arrangement  under  the  federal  bankruptcy  laws  or any  other
               applicable  law or statute of the United States of America or any
               state thereof;

         (d) if a court of competent jurisdiction shall enter an order, judgment
or decree  appointing,  without  the consent of the  Company,  a receiver of the
Company or of the whole or any substantial part of its property,  or approving a
petition filed against it seeking  reorganization  or arrangement of the Company
under the federal  bankruptcy laws or any other applicable law or statute of the
United  States of America or any State  thereof,  and such  order,  judgment  or
decree shall not be vacated or set aside or stayed  within thirty (30) days from
the date of entry thereof;

         (e) if, under the  provisions of any other law for the relief or aid of
debtors, any court of competent  jurisdiction shall assume custody or control of
the  Company  or the  whole or any  substantial  part of its  property  and such
custody or control  shall not be  terminated  or stayed  within thirty (30) days
from the date of assumption of such custody or control;

         (f) the liquidation, dissolution or winding up of the Company;

         (g) the  failure of the  shareholders  to  authorize  and  approve  the
issuance  of these  Notes or the  issuance  of the shares of Series D  Preferred
Stock  underlying  these Notes, the Bridge Warrants or the New Warrants (as such
terms are defined in the Purchase Agreement), or any Common Stock underlying the
foregoing to the extent such authorization is necessary pursuant to the rules of
the Nasdaq National Market or any other applicable law, rule or regulation.

         (h) A default or event of default which remains  uncured  following any
applicable cure period under the Security Agreement; or

         (i) A final judgment or judgments for the payment of money in excess of
$1,000,000  in  the  aggregate   shall  be  rendered  by  one  or  more  courts,
administrative or arbitral tribunals or other bodies having jurisdiction against
the Company and the same shall not be discharged (or provision shall not be made
for such  discharge),  or a stay of  execution  thereof  shall not be  procured,
within 30 days from the date of entry thereof and the Company shall not,  within
such 30-day  period,  or such longer period  during which  execution of the same
shall have been stayed,  appeal therefrom and cause the execution  thereof to be
stayed during such appeal; or


SECTION 8. REMEDIES UPON EVENT OF DEFAULT.

         (a)  Upon  the  occurrence  of an  Event  of  Default,  (i) the  entire
principal  amount of, and all  accrued and unpaid  interest  on, this Note shall
automatically  become immediately due and payable without  presentment,  demand,
protest or other  formalities  of any kind,  all of which are  hereby  expressly
waived by the Company and (ii)  additional  interest shall begin to accrue,  and
shall be considered  immediately due and payable, on the unpaid principal amount
of this Note at the rate of eighteen  percent (18%) per annum and shall continue
to accrue  until the  initial  interest  and  additional  interest  is paid.  In
addition,  the  Holder may take any action  available  to it under the  Purchase
Agreement or at law or in equity or by statute or otherwise.

         (b) No remedy herein conferred upon the Holder of this Note is intended
to be  exclusive  of any other  remedy and each and every such  remedy  shall be
cumulative and shall be in addition to every other remedy given hereunder or now
or hereafter existing at law or in equity or by statute or otherwise.


SECTION 9. NOTE REGISTER.

         (a) The Company shall keep at its principal executive office a register
(herein sometimes referred to as the "Note Register"), in which, subject to such
reasonable  regulations  as it may  prescribe,  but at its  expense  (other than
transfer  taxes,  if any),  the Company shall provide for the  registration  and
transfer of this Note.


                                       -8-


<PAGE>

         (b) Whenever this Note shall be surrendered at the principal  executive
office  of the  Company  for  transfer  or  exchange,  accompanied  by a written
instrument  of  transfer in form  reasonably  satisfactory  to the Company  duly
executed by the Holder  hereof or his attorney duly  authorized in writing,  the
Company shall execute and deliver in exchange  therefor a new Note or Notes,  as
may be requested by such Holder,  in the same aggregate  unpaid principal amount
and  payable  on the same date as the  principal  amount of the Note or Notes so
surrendered;  each such new Note shall be dated as of the date to which interest
has been paid on the unpaid principal amount of the Note or Notes so surrendered
and shall be in such  principal  amount and  registered in such name or names as
such Holder may designate in writing.

         (c) Upon receipt by the Company of evidence reasonably  satisfactory to
it of the loss,  theft,  destruction or mutilation of this Note and of indemnity
reasonably  satisfactory  to it, and upon  reimbursement  to the  Company of all
reasonable expenses  incidental thereto,  and upon surrender and cancellation of
this Note (in case of  mutilation)  the Company will make and deliver in lieu of
this Note a new Note of like tenor and unpaid  principal  amount and dated as of
the date to which interest has been paid on the unpaid  principal amount of this
Note in lieu of which such new Note is made and delivered.


SECTION 10. REGISTRATION UNDER SECURITIES ACT OF 1933.

         The Holder of this Note shall have  registration  rights as provided in
Section 8 of the Purchase Agreement,  with respect to the shares of Common Stock
underlying the Series D Preferred  Stock  issuable upon  conversion of the Notes
pursuant to the Optional and Default  Conversion  Right.  If the Holder is not a
party to the Purchase  Agreement,  by acceptance of this Note, the Holder agrees
to comply with  provisions  of Section 8 of the  Purchase  Agreement to the same
extent as if it were a party thereto.


SECTION 11. MISCELLANEOUS.

         (a)  Amendments  and Waivers.  The holders of sixty-six and  two-thirds
percent (66 2/3%) or more in principal amount of outstanding Notes of this issue
may waive or otherwise consent to the amendment of any of the provisions hereof,
provided that no such waiver or amendment may reduce the principal  amount of or
interest on any of the Notes of this issue or change the stated  maturity of the
principal or reduce the  percentage of holders of Notes of this issue  necessary
to waive or amend the  provisions  of this  Note,  without  the  consent of each
holder of any Note affected thereby.

         (b)  Restrictions on  Transferability.  In addition to the restrictions
set forth in Section 9(a) of this Note, the securities  represented by this Note
have  been  acquired  for  investment  and have not been  registered  under  the
Securities Act of 1933, as amended, or the securities laws of any state or other
jurisdiction.  Without  such  registration,  such  securities  may not be  sold,
pledged,  hypothecated or otherwise  transferred,  except pursuant to exemptions
from the Securities  Act of 1933, and the securities  laws of any state or other
jurisdiction.  Notwithstanding  the  above,  the  holder  of this  Note has been
provided  the  registration  rights  contained  in  Section  8 of  the  Purchase
Agreement with respect to the shares of the Company's  Common Stock which may be
acquired upon exercise of the Optional and Default Conversion Right.

         (c)  Forbearance  from  Suit.  No holder of Notes of this  issue  shall
institute any suit or proceeding for the enforcement of the payment of principal
or interest unless the holders of at least fifty-one  percent (51%) in principal
amount  of all of the  outstanding  Notes  of this  issue  join in such  suit or
proceeding.

         (d)  Governing  Law.  This Note shall be governed by and  construed  in
accordance  with the laws of the  State of New York,  excluding  the body of law
relating to conflict of laws. Notwithstanding anything to the contrary contained
herein, in no event may the effective rate of interest  collected or received by
the Holder exceed that which may be charged, collected or received by the Holder
under applicable law.


                                       -9-


<PAGE>

         (e) Interpretation. If any term or provision of this Note shall be held
invalid,  illegal  or  unenforceable,  the  validity  of  all  other  terms  and
provisions hereof shall in no way be affected thereby.

         (f) Successors and Assigns. This Note shall be binding upon the Company
and its  successors and assigns and shall inure to the benefit of the Holder and
its successors and assigns.

         (g) Notices. All notices, requests,  consents and demands shall be made
in writing and shall be mailed  postage  prepaid,  or delivered by hand,  to the
Company or to the Holder thereof at their  respective  addresses set forth below
or to such other  address  as may be  furnished  in  writing to the other  party
hereto:

                  If to the Holder:         At the address shown on Schedule A 
                                            attached hereto.

                  with a copy to:           Paramount Capital, Inc.
                                            787 Seventh Avenue
                                            New York, NY  10019
                                            Attn: David R. Walner

                  If to the Company:        Genta Incorporated
                                            3350 General Atomics Court
                                            San Diego, CA 92121
                                            Attention: Chief Executive Officer

         (h) Saturdays,  Sundays,  Holidays. If any date that may at any time be
specified  in this Note as a date for the making of any payment of  principal or
interest under this Note shall fall on Saturday, Sunday or on a day which in New
York  shall be a legal  holiday,  then the date for the  making of that  payment
shall be the  next  subsequent  day  which is not a  Saturday,  Sunday  or legal
holiday.

         (i) Purchase Agreement.  This Note is subject to the terms contained in
the  Purchase  Agreement  dated the date hereof  between the Company and certain
purchasers of the Senior Secured Convertible Bridge Notes and the holder of this
Note is entitled to the benefits of such Purchase Agreement and may, in addition
to any rights hereunder, enforce the agreements of the Company contained therein
and exercise the remedies provided for thereby or otherwise available in respect
thereof.


                                      -10-


<PAGE>

         IN WITNESS  WHEREOF,  this Note has been  executed  and  delivered as a
sealed  instrument  on the date  first  above  written  by the  duly  authorized
representative of the Company.


ATTEST:                               GENTA INCORPORATED


                                      By: /s/ Thomas H. Adams
- -----------------------                   -----------------------
                                      Name: Dr. Thomas H. Adams
                                      Its: President and Chief Executive Officer



(Corporate Seal)


                                      -11-



                                                                    EXHIBIT 10.4

THIS NOTE IS NOT  TRANSFERABLE  WITHOUT  THE  EXPRESS  WRITTEN  CONSENT OF GENTA
INCORPORATED,  (THE "COMPANY"). THE SECURITIES REPRESENTED BY THIS NOTE HAVE NOT
BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF  1933 OR ANY  APPLICABLE  STATE
SECURITIES LAWS, AND MAY NOT BE SOLD,  OFFERED FOR SALE, PLEDGED OR HYPOTHECATED
OR OTHERWISE  TRANSFERRED IN THE ABSENCE OF A  REGISTRATION  STATEMENT IN EFFECT
WITH RESPECT TO THE  SECURITIES  UNDER SUCH ACT OR AN EXEMPTION  THEREFROM.  ANY
SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE STATE SECURITIES LAWS.


                               GENTA INCORPORATED

                                                                          No.B-2
                     SENIOR SECURED CONVERTIBLE BRIDGE NOTE

$1,950,000                                                    New York, New York
                                                              January 28, 1997

         Genta Incorporated, a Delaware corporation,  (the "Company"), for value
received,  hereby  promises  to  pay to  THE  ARIES  TRUST  (the  "Holder"),  or
registered assigns, the principal sum of ONE MILLION NINE HUNDRED FIFTY THOUSAND
DOLLARS  ($1,950,000),  with  interest  from the date of issuance of this Senior
Secured  Convertible Bridge Note on the unpaid principal balance at a rate equal
to twelve  percent (12%) per annum,  on the earlier of (a) June 30, 1997 and (b)
five (5) business days following the completion of any equity offering or series
of equity  offerings with gross proceeds in excess of $2,500,000  (the "Maturity
Date").  Payment  shall be made at such place as  designated  by the Holder upon
surrender of this Senior Secured  Convertible  Bridge Note, and shall be in such
coin or currency of the United States of America as at the time of payment shall
be legal tender for the payment of public and private  debts.  Interest shall be
computed on the basis of a 360-day  year of twelve  30-day  months.  This Senior
Secured  Convertible  Bridge  Note is one of a duly  authorized  issue  of Genta
Incorporated  12% Senior  Convertible  Bridge  Notes in an  aggregate  principal
amount of $3,000,000 (individually a "Note" and collectively the "Notes") issued
pursuant to a Note and Warrant Purchase  Agreement of even date herewith between
the  Company  and the Holder  (the  "Purchase  Agreement").  The Senior  Secured
Convertible  Bridge  Notes  shall be  senior to all  other  indebtedness  of the
Company ("Other  Indebtedness") and all Other Indebtedness shall be subordinated
to the Senior  Bridge  Notes.  These Notes are secured  pursuant to the Security
Agreement  dated as of January 28, 1997 by and  between the  Company,  Paramount
Capital, Inc. and the Purchasers.

SECTION 1. PREPAYMENT.

         This Note (including  interest accrued on the principal  hereof) may be
prepaid by the Company, at any time without penalty or premium provided that the
Company  shall  provide  the  holders  of the Notes  with at least 30 days prior
written notice of prepayment,  and prior to such prepayment,  the holders of the
Notes shall have the  opportunity to exercise their optional  conversion  rights
pursuant to Section 2 hereof.

SECTION 2. OPTIONAL CONVERSION

         (a) Right of Conversion. (i) Immediately,  or, (ii) if the rules of the
Nasdaq National  Market or any other law or regulation,  require the approval of
the shareholders of the Company to permit convertibility of the Notes, then upon
the receipt of such approvals,  the Notes shall be  convertible,  in whole or in
part, at the option of the holder thereof and upon notice to the  Corporation as
set  forth in  paragraph  2(b)  below,  into the  number  of  shares of Series D
Preferred Stock of the Company (the  "Preferred  Stock") equal to the Conversion
Amount  divided by the then current  Conversion  Price (as defined  below).  The
Conversion  Amount shall be the Liquidation  Amount, or in the case of a partial
conversion,  such lesser  amount as  designated by the  converting  holder.  The
Liquidation  Amount shall be the aggregate  principal value of the Notes held by
such Holder plus any accrued and unpaid  interest.  The  Conversion  Price shall
initially be $5.00,  subject to adjustment as provided  below,  representing  an
initial  conversion  rate  (subject to  adjustment)  of 2000 shares of Preferred
Stock per $10,000 of Conversion Amount.


                                       -1-


<PAGE>

         (b) Conversion Procedures. Any holder of Notes desiring to convert such
Notes into  Preferred  Stock  shall  surrender  the Notes at the  offices of the
Company,  which Notes shall be accompanied by irrevocable  written notice to the
Corporation  that the holder elects so to convert such Notes and  specifying the
name or names (with address) in which a certificate or  certificates  evidencing
shares of Preferred Stock are to be issued. The Corporation will make a notation
of the date that a notice of conversion is received,  which date shall be deemed
to be the date of receipt for purposes hereof.

         The Corporation shall deliver to the holder converting the Notes, or to
the nominee or nominees of such person,  certificates  evidencing  the number of
full  shares of  Preferred  Stock to which  such  person  shall be  entitled  as
aforesaid,  together  with a cash  adjustment  of any  fraction  of a  share  as
hereinafter  provided.  Subject to the following  provisions of this  paragraph,
such  conversion  shall  be  deemed  to have  been  made as of the  date of such
surrender  of the Notes and the  person  or  persons  entitled  to  receive  the
Preferred Stock  deliverable  upon conversion of such Notes shall be treated for
all  purposes as the record  holder or holders of such  Preferred  Stock on such
date; provided,  however,  that the Corporation shall not be required to convert
any Notes while the stock transfer books of the  Corporation  are closed for any
purpose,  but the surrender of Notes for conversion during any period while such
books are so closed shall become  effective for conversion  immediately upon the
reopening  of such books as if the  surrender  had been made on the date of such
reopening,  and the conversion shall be at the conversion rate in effect on such
date.

         All notices of conversion shall be irrevocable; provided, however, that
if the  Corporation  has sent  notice of an event  pursuant  to  paragraph  2(e)
hereof,  a holder  of Notes  may,  at its  election,  provide  in its  notice of
conversion  that  the  conversion  of its  Notes  shall be  contingent  upon the
occurrence  of the record date or  effectiveness  of such event (as specified by
such  holder),  provided  that such  notice of  conversion  is  received  by the
Corporation prior to such record date or effective date, as the case may be.

         (c) Protection From Dilution.  (i) If, at any time or from time to time
after the date of this  Note,  the  Company  shall  issue or  distribute  to the
holders of shares of Preferred  Stock  evidence of its  indebtedness,  any other
securities  of the Company or any cash,  property or other  assets  (excluding a
subdivision,  combination  or  reclassification,  or  dividend  or  distribution
payable  solely to  holder of  Preferred  Stock in  shares of  Preferred  Stock,
referred to in Subsection  (c)(ii),  and also  excluding  cash dividends or cash
distributions  paid out of net profits  legally  available  therefor in the full
amount  thereof  (any such  non-excluded  event being  herein  called a "SPECIAL
DIVIDEND"), the Conversion Price shall be adjusted by multiplying the Conversion
Price then in effect by a  fraction,  the  numerator  of which shall be the then
Current  Market Price Per Share of Preferred  Stock in effect on the record date
of such issuance or  distribution  less the fair market value (as  determined in
good faith by the Company's Board of Directors) of the evidence of indebtedness,
cash,  securities  or property,  or other assets issued or  distributed  in such
Special Dividend  applicable to one share of Preferred Stock and the denominator
of which shall be the then Current Market Price Per Share of Preferred  Stock in
effect on the record date of such issuance or  distribution.  An adjustment made
pursuant to this Subsection 2(a) shall become  effective  immediately  after the
record date of any such Special  Dividend.  The then  "CURRENT  MARKET PRICE PER
SHARE OF PREFERRED  STOCK" shall equal the then Current Market Price  multiplied
by the then effective  "conversion rate" (as defined and used in the Certificate
of Designation for the Series D Preferred Stock).

The then Current  Market Price per share (the "CURRENT  MARKET  PRICE") shall be
deemed to be the last sale price of the Common Stock on the trading day prior to
such date or, in case no such reported sales take place on such day, the average
of the last  reported  bid and asked  prices of the Common Stock on such day, in
either case on the principal  national  securities  exchange on which the Common
Stock is admitted to trading or listed,  or if not listed or admitted to trading
on any such exchange,  the representative  closing bid price of the Common Stock
as reported by the National  Association of Securities  Dealers,  Inc. Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined in good faith by the Board of Directors.


                                       -2-


<PAGE>

         (ii) In case the Company  shall  hereafter (i) pay a dividend or make a
distribution on its capital stock in shares of Preferred  Stock,  (ii) subdivide
its outstanding shares of Preferred Stock into a greater number of shares, (iii)
combine  its  outstanding  shares of  Preferred  Stock into a smaller  number of
shares or (iv) issue by  reclassification  of its Preferred  Stock any shares of
capital stock of the Company (other than the Conversion Shares),  the Conversion
Price shall be  proportionately  adjusted so that the Notes shall be convertible
into a number and kind of securities  which the holders would have been entitled
to receive after any such event had they converted the Notes  immediately  prior
thereto.  An  adjustment  made  pursuant to this  Subsection  2(b) shall  become
effective  immediately  after  the  record  date in the  case of a  dividend  or
distribution and shall become effective  immediately after the effective date in
the case of a subdivision, combination or reclassification.

         (iii) Except as provided in Subsections (c)(i) and (c)(iv), in case the
Company  shall  hereafter  issue or sell any  Preferred  Stock,  any  securities
convertible into Preferred  Stock,  any rights,  options or warrants to purchase
Preferred Stock or any securities convertible into Preferred Stock, in each case
for a price per share or  entitling  the holders  thereof to purchase  Preferred
Stock at a price per share (determined by dividing (i) the total amount, if any,
received or receivable by the Company in  consideration  of the issuance or sale
of such securities plus the total consideration,  if any, payable to the Company
upon  exercise or  conversion  thereof (the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of  Preferred  Stock  issuable  upon  exercise  or
conversion of such securities) which is less than either the then Current Market
Price Per Share of  Preferred  Stock in effect on the date of such  issuance  or
sale or the Conversion  Price,  the Conversion Price shall be adjusted as of the
date of such issuance or sale by multiplying the Conversion Price then in effect
by a fraction,  the numerator of which shall be (x) the sum of (A) the number of
shares of Preferred  Stock  outstanding  on the record date of such  issuance or
sale plus (B) the Total  Consideration  divided by the Current  Market Price Per
Share of Preferred Stock or the current Conversion Price,  whichever is greater,
and the  denominator  of which  shall be (y) the  number of shares of  Preferred
Stock  outstanding  on the record date of such issuance or sale plus the maximum
number of additional  shares of Preferred  Stock  issued,  sold or issuable upon
exercise or conversion of such securities.

         (iv) In case of any capital reorganization or reclassification,  or any
consolidation  or merger to which the  Company is a party other than a merger or
consolidation in which the Company is the continuing corporation,  or in case of
any sale or  conveyance  to another  entity of the property of the Company as an
entirety  or  substantially  as a  entirety,  or in the  case  of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Note shall have the right  thereafter  to receive on the  conversion  of
this Note the kind and amount of  securities,  cash or other  property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had  this  Note  been  converted  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 2 with respect to the rights and  interests  thereafter of
the Holder of this Note to the end that the provisions set forth in this Section
2  shall  thereafter  correspondingly  be  made  applicable,  as  nearly  as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  Note.  The above  provisions  of this
Subsection   (c)(iv)  shall  similarly  apply  to  successive   reorganizations,
reclassifications,   consolidations,  mergers,  statutory  exchanges,  sales  or
conveyances.  The  Company  shall  require  the issuer of any shares of stock or
other securities or property thereafter deliverable on the exercise of this Note
to be  responsible  for all of the  agreements  and  obligations  of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the Notes not less than
30 days prior to such event. A sale of all or substantially all of the assets of
the Company for a  consideration  consisting  primarily of  securities  shall be
deemed a consolidation or merger for the foregoing purposes.

         (v) In case any event shall occur as to which the other  provisions  of
this Section 2 are not strictly  applicable  but as to which the failure to make
any adjustment  would not fairly protect the  conversion  rights  represented by
this Note in accordance with 


                                       -3-


<PAGE>

the essential intent and principles  hereof then, in each such case, the Holders
of Notes may appoint a firm of  independent  public  accountants  of  recognized
national standing reasonably  acceptable to the Company,  which shall give their
opinion as to the adjustment,  if any, on a basis  consistent with the essential
intent and principles  established herein,  necessary to preserve the conversion
rights.  Upon receipt of such  opinion,  the Company will  promptly  mail a copy
thereof  to the  Holder of this Note and shall  make the  adjustments  described
therein.  The fees and expenses of such independent  public accountants shall be
borne by the Company.

         (vi) For  purposes of the  anti-dilution  protection  contained in this
Section (c), at all times  following  the  conversion of all shares of Preferred
Stock into shares of Common Stock,  the term Preferred Stock shall be read to be
Common Stock,  context  permitting,  so that the  anti-dilution  provisions will
continue to protect the  conversion  rights  represented  by this Note after the
conversion of all the Preferred  Stock into the Common Stock in accordance  with
the essential  intent and principles of this Section 3 (it being understood that
prior to such conversion,  the  anti-dilution  provisions of the Preferred Stock
underlying  this Note shall be applicable to any dilutive events with respect to
the Common Stock and protect the Holder from dilution of the Common Stock).

         (d) Reservation of Shares;  Transfer Taxes;  Etc. The Corporation shall
at all times  reserve and keep  available,  out of its  authorized  and unissued
shares of Preferred Stock, solely for the purpose of effecting the conversion of
the Notes,  such  number of shares of its  Preferred  Stock  free of  preemptive
rights as shall be sufficient to effect the conversion of all Notes from time to
time outstanding.  The Corporation shall use its best efforts from time to time,
in accordance with the laws of the State of Delaware, to increase the authorized
number  of  shares  of  Preferred  Stock if at any time the  number of shares of
Preferred Stock not outstanding shall not be sufficient to permit the conversion
of all the then-outstanding Notes.

         The Corporation  shall pay any and all issue or other taxes that may be
payable in  respect of any issue or  delivery  of shares of  Preferred  Stock on
conversion of the Notes. The Corporation shall not, however,  be required to pay
any tax which may be payable in respect of any transfer involved in the issue or
delivery of Preferred Stock (or other securities or assets) in a name other than
that in which the  Notes so  converted  were  registered,  and no such  issue or
delivery  shall be made  unless and until the person  requesting  such issue has
paid to the  Corporation  the  amount  of such  tax or has  established,  to the
satisfaction of the Corporation, that such tax has been paid.

         (e) Prior Notice of Certain Events. In case:

               (i) the  Corporation  shall  declare any  dividend  (or any other
               distribution); or

               (ii) the Corporation  shall authorize the granting to the holders
               of  Preferred  Stock of rights or  warrants to  subscribe  for or
               purchase  any shares of stock of any class or of any other rights
               or warrants; or

               (iii) of any  reclassification  of Preferred  Stock (other than a
               subdivision or combination of the outstanding Preferred Stock, or
               a change in par value, or from par value to no par value, or from
               no par value to par value); or

               (iv) of any consolidation or merger to which the Corporation is a
               party  and  for  which  approval  of  any   stockholders  of  the
               Corporation shall be required,  or of the sale or transfer of all
               or  substantially  all of the assets of the Corporation or of any
               compulsory   share  exchange   whereby  the  Preferred  Stock  is
               converted into other securities, cash or other property; or

               (v) of the voluntary or involuntary  dissolution,  liquidation or
               winding up of the Corporation;

then the Corporation  shall cause to be mailed to the holders of Notes, at their
last addresses as they shall appear upon the books of the Corporation,  at least
20 days prior to the  applicable  record date  hereinafter  specified,  a notice
stating  (x) the date on which a record (if any) is to be taken for the  purpose
of such dividend, distribution or granting of rights or warrants or, if a record
is not to be  taken,  the date as of which the  holders  of  


                                       -4-


<PAGE>

Preferred Stock of record to be entitled to such dividend, distribution,  rights
or warrants are to be determined  and a description  of the cash,  securities or
other property to be received by such holders upon such  dividend,  distribution
or   granting   of  rights  or   warrants   or  (y)  the  date  on  which   such
reclassification,   consolidation,   merger,  sale,  transfer,  share  exchange,
dissolution, liquidation or winding up or other liquidation event is expected to
become effective,  the date as of which it is expected that holders of Preferred
Stock of record shall be entitled to exchange  their  shares of Preferred  Stock
for securities or other property  deliverable  upon such exchange,  dissolution,
liquidation  or winding  up or other  liquidation  event and the  consideration,
including securities or other property, to be received by such holders upon such
exchange;  provided,  however, that no failure to mail such notice or any defect
therein or in the mailing  thereof  shall affect the  validity of the  corporate
action required to be specified in such notice.

         (f) Other Changes in Conversion Rate. The Corporation from time to time
may  increase  the  Conversion  Rate by any amount for any period of time if the
period is at least 20 days and if the increase is irrevocable during the period.
Whenever the  Conversion  Rate is so increased,  the  Corporation  shall mail to
holders of record of Notes a notice of the  increase at least 15 days before the
date the increased Conversion Rate takes effect, and such notice shall state the
increased Conversion Rate and the period it will be in effect.

         The  Corporation  may make such  increases in the  Conversion  Rate, in
addition  to  those  required  or  allowed  by this  paragraph  4, as  shall  be
determined by it, as evidenced by a resolution of the Board of Directors,  to be
advisable  in order to avoid or  diminish  any  income  tax to holders of Common
Stock resulting from any dividend or distribution of stock or issuance of rights
or warrants to purchase or subscribe for stock or from any event treated as such
for income tax purposes.


SECTION 3. DEFAULT CONVERSION.

         (a) If this Note and all accrued  interest  shall not have been paid in
full on or  before  the  Maturity  Date or upon  the  occurrence  of an Event of
Default (as defined in Section 7 hereof),  the Holder  shall have the right (the
"Default  Conversion  Right"),  in addition to any other available  remedies set
forth in Section 8 hereof or at law or in equity, to convert up to the lesser of
(i) the  then  outstanding  principal  amount  of this  Note or (ii)  10% of the
original  principal  amount of this  Note,  into the  number of shares of Common
Stock of the Company  ("Common  Stock"),  equal to the amount  converted  by the
Noteholder upon such Event of Default (the "Default  Conversion Amount") divided
by $.001 (the "Default  Conversion Price").  Upon conversion,  the Company shall
pay all accrued and unpaid interest on the Default Conversion Amount.

         (b) To exercise the Default  Conversion Right, the Holder, on or before
the 60th day after the  Maturity  Date,  but before  payment in full of the then
outstanding  principal  and  interest  under  this  Note,  shall  deliver to the
Company,  at its office at as set forth in section 11, or at such other place as
is  designated  in writing by the Company,  a notice (the  "Conversion  Notice")
stating that the Holder is exercising the Default  Conversion Right, the Default
Conversion  Amount  and the  name or  names  in  which  the  Holder  wishes  the
certificates for shares of Common Stock to be issued.

         (c) To the extent  permitted by  applicable  law,  upon exercise of the
Default  Conversion Right, the Holder shall be deemed to be the holder of record
of the shares of Common  Stock  issuable  upon such  exercise  (the  "Conversion
Shares"),  notwithstanding  that the transfer books of the Company shall then be
closed or certificates  representing  such Conversion Shares shall not then have
been actually  delivered to the Holder.  As soon as practicable and in any event
within five (5) days after exercise of the Default Conversion Right, the Company
shall issue and deliver to the Holder a certificate or  certificates  evidencing
the  Conversion  Shares  registered  in the name of the Holder or its  designee,
provided that the Company may require the holder,  by notice given to the Holder
promptly after receipt of the Conversion  Notice, as a condition to the delivery
of such certificate or certificates, to present this Note to the Company for the
placement  hereon of a legend  indicating that the Default  Conversion Right has
been  exercised to the extent of the Default  Conversion  Amount,  and this Note
(unless thereby paid in full) shall be immediately returned to the Holder.


                                       -5-


<PAGE>

         (d) The issuance of any shares or other securities upon the exercise of
the  Default  Conversion  Right,  and the  delivery  of  certificates  or  other
instruments representing such shares or other securities,  shall be made without
charge to the  Holder for any tax or other  charge in respect of such  issuance.
The Company shall not, however,  be required to pay any tax which may be payable
in respect of any transfer involved in the issue and delivery of any certificate
in a name other than that of the Holder and the Company shall not be required to
issue or  deliver  any such  certificate  unless and until the person or persons
requesting  the issue  thereof shall have paid to the Company the amount of such
tax or shall have  established to the  satisfaction of the Company that such tax
has been paid.

         (e) The Holder  shall not have,  solely on account of such  status as a
Holder of this Note, any rights of a stockholder  of the Company,  either at law
or in  equity,  or any  notice  of  meetings  of  stockholders  or of any  other
proceedings of the Company except as provided in this Note.

         (f) The Company shall at all times following the Issuance Date, reserve
and keep available out of its  authorized  and unissued  shares of Common Stock,
solely for the purpose of providing  for the exercise of the Default  Conversion
Right,  such number of shares of Common  Stock as shall,  from time to time,  be
sufficient for the exercise of the Default Conversion Right in full. The Company
covenants  that all shares of Common Stock issuable upon exercise of the Default
Conversion Right shall be validly issued, fully paid and nonassessable.

         (g) The  anti-dilution  protections  set forth in Section  2(c)  hereof
shall apply as well to the Default  Conversion  Right and the  adjustment of the
Default Conversion Price hereunder, provided, however, that for purposes of such
application  all  appropriate  references  to  Preferred  Stock shall be read as
references to Common Stock and all references to the  Conversion  Price shall be
read as references to the Default  Conversion  Price,  so as to give the Default
Conversion  Rights,  as  nearly  as  practicable,  the  anti-dilution  and other
protections provided for in section 2(c) with respect to the Optional Conversion
Right.


SECTION 4. FRACTIONAL SHARES.

         (a) The Company  shall not be required to issue  fractions of shares of
Common  Stock or other  capital  stock of the Company  upon the  exercise of the
Optional  and  Default  Conversion  Right.  If any  fraction of a share would be
issuable  on any  exercise  of the  Optional  or  Default  Conversion  Right (or
specified  portions  thereof),  the Company shall  purchase such fraction for an
amount in cash equal to the same  fraction of the  closing  price for the Common
Stock on the  trading  date  immediately  preceding  the date of exercise of the
Optional or Default Conversion Right.


SECTION 5. AFFIRMATIVE COVENANTS OF THE COMPANY.

         The Company covenants and agrees that until the payment in full of this
Note, the Company shall:

         (a) Existence; Business. (i) Preserve, renew and keep in full force and
effect its legal existence and (ii) obtain, preserve,  renew, extend and keep in
full force and effect the licenses, permits, authorizations, patents, trademarks
and trade names material to its business.

         (b) Use of Proceeds. Use the proceeds of the Notes of this issue solely
as set forth in Section 7.7 of the Note and Warrant Purchase  Agreement  between
the  Company  and  various  purchasers  dated  the date  hereof  (the  "Purchase
Agreement")

         (c)  Reports.  Furnish  to the  Holder,  at the time  furnished  to the
Company's   stockholders,   reports   furnished   generally  to  the   Company's
stockholders, and copies of Current Reports on Form 8-K.

         (d) Notice of Events of Default.  Furnish to the Holder prompt  written
notice of any Event of  Default,  specifying  the nature and extent  thereof and
corrective action, if any, proposed to be taken with respect thereto.


                                       -6-


<PAGE>

         (e) Authorization of Stock Issuable Upon Conversion.  No later than the
Maturity  Date,  authorize  and  reserve a  sufficient  number of its shares for
exercise of the Default Conversion Right.


SECTION 6. NEGATIVE COVENANTS OF THE COMPANY.

         The Company covenants and agrees with the Holder that until the payment
in full of this Note, the Company shall not:

         (a)  Indebtedness.  Incur,  create,  assume  or  permit  to  exist  any
indebtedness except (i) indebtedness represented by the Notes, (ii) indebtedness
which by its terms is  subordinated  to the Notes in an amount less than $25,000
in the  aggregate  (iii)  indebtedness  in an amount  less than  fifty  thousand
dollars  ($50,000)  incurred  in the  ordinary  course  of  business,  and  (iv)
indebtedness  for borrowed  money  existing on the date hereof and  disclosed in
writing to the Holder on or prior to the date  hereof,  but not any  extensions,
renewals or replacements of such indebtedness;

         (b)  Liens.  Create,  incur,  assume or permit to exist any lien on any
property or assets (including stock or other securities of any person) now owned
or hereafter acquired by the Company,  except (i) liens for taxes not yet due or
which  are  being   contested  by  appropriate   proceedings;   (ii)  carriers',
warehousemen's,  mechanic's,  materialmen's,  repairmen's  or other  like  liens
arising in the ordinary course of business and securing obligations that are not
due or which are being  contested;  or (iii) liens of attachments,  judgments or
awards against the Company (X) which could not reasonably be expected to have an
adverse material effect on the Company or (Y) with respect to which an appeal or
proceeding  for review shall be pending or a stay of  execution  shall have been
obtained,  or  which  are  otherwise  being  contested  in  good  faith  and  by
appropriate  proceedings,  or (iv) purchase  money liens,  equipment  leases and
financings incurred in the ordinary course of business.

         (c) Sale  and  Lease-Back  Transactions.  Enter  into any  arrangement,
directly or  indirectly,  with any person  whereby it shall sell or transfer any
property, real or personal, used or useful in its business, whether now owned or
hereafter acquired, and thereafter rent (including intellectual property), lease
or  license  such  property  or  other  property  which  it  intends  to use for
substantially  the same  purpose  or  purposes  as the  property  being  sold or
transferred.

         (d) Mergers,  Consolidations,  Sales of Assets and Acquisitions.  Merge
into or consolidate  with any other person,  or permit any other person to merge
into or consolidate with it, or sell,  transfer,  lease or otherwise  dispose of
(in one transaction or in a series of transactions) all or a substantial part of
its assets  (whether  now owned or hereafter  acquired)  or  purchase,  lease or
otherwise  acquire (in one  transaction  or a series of  transactions)  all or a
substantial part of the assets of any other person.

         (e)  Dividends  and   Distributions.   Declare  or  pay,   directly  or
indirectly, any dividend or make any other distribution (by reduction of capital
or otherwise),  whether in cash, property,  securities or a combination thereof,
with  respect to any  shares of its  capital  stock or  directly  or  indirectly
redeem, purchase,  retire or otherwise acquire for value any shares of any class
of its  capital  stock or set aside any amount for any such  purpose,  except as
permitted by Section 7.15 of the Note and Warrant Agreement.

         (f)  No   Impairment.   By   amendment   of  its   charter  or  through
reorganization,  consolidation, merger, dissolution, sale of assets or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the  terms of this  Note,  but will at all  times in good  faith  assist  in the
carrying  out of all such terms and in the  taking of all such  action as may be
necessary  or  appropriate  in order to protect the rights of the Holder of this
Note against impairment.


SECTION 7. EVENTS OF DEFAULT DEFINED.

         The following shall each constitute an "Event of Default" hereunder:


                                       -7-


<PAGE>

         (a) the failure of the Company to make any payment of  principal  of or
interest on this Note when due and payable;

         (b) the failure of the  Company to observe or perform  any  covenant in
this Note or in the Purchase  Agreement,  and such failure shall have  continued
unremedied for a period of five (5) days;

         (c) if the Company shall:

               (1) admit in writing its inability to pay its debts  generally as
               they become due,

               (2) file a petition in bankruptcy or a petition to take advantage
               of any insolvency act,

               (3) make an assignment for the benefit of its creditors,

               (4) consent to the  appointment of a receiver of itself or of the
               whole or any substantial part of its property,

               (5) on a petition in bankruptcy  filed against,  be adjudicated a
               bankrupt, or

               (6)  file  a  petition  or  answer  seeking   reorganization   or
               arrangement  under  the  federal  bankruptcy  laws  or any  other
               applicable  law or statute of the United States of America or any
               state thereof;

         (d) if a court of competent jurisdiction shall enter an order, judgment
or decree  appointing,  without  the consent of the  Company,  a receiver of the
Company or of the whole or any substantial part of its property,  or approving a
petition filed against it seeking  reorganization  or arrangement of the Company
under the federal  bankruptcy laws or any other applicable law or statute of the
United  States of America or any State  thereof,  and such  order,  judgment  or
decree shall not be vacated or set aside or stayed  within thirty (30) days from
the date of entry thereof;

         (e) if, under the  provisions of any other law for the relief or aid of
debtors, any court of competent  jurisdiction shall assume custody or control of
the  Company  or the  whole or any  substantial  part of its  property  and such
custody or control  shall not be  terminated  or stayed  within thirty (30) days
from the date of assumption of such custody or control;

         (f) the liquidation, dissolution or winding up of the Company;

         (g) the  failure of the  shareholders  to  authorize  and  approve  the
issuance  of these  Notes or the  issuance  of the shares of Series D  Preferred
Stock  underlying  these Notes, the Bridge Warrants or the New Warrants (as such
terms are defined in the Purchase Agreement), or any Common Stock underlying the
foregoing to the extent such authorization is necessary pursuant to the rules of
the Nasdaq National Market or any other applicable law, rule or regulation.

         (h) A default or event of default which remains  uncured  following any
applicable cure period under the Security Agreement;

         (i) A final judgment or judgments for the payment of money in excess of
$1,000,000  in  the  aggregate   shall  be  rendered  by  one  or  more  courts,
administrative or arbitral tribunals or other bodies having jurisdiction against
the Company and the same shall not be discharged (or provision shall not be made
for such  discharge),  or a stay of  execution  thereof  shall not be  procured,
within 30 days from the date of entry thereof and the Company shall not,  within
such 30-day  period,  or such longer period  during which  execution of the same
shall have been stayed,  appeal therefrom and cause the execution  thereof to be
stayed during such appeal; or

SECTION 8. REMEDIES UPON EVENT OF DEFAULT.


                                       -8-


<PAGE>

         (a)  Upon  the  occurrence  of an  Event  of  Default,  (i) the  entire
principal  amount of, and all  accrued and unpaid  interest  on, this Note shall
automatically  become immediately due and payable without  presentment,  demand,
protest or other  formalities  of any kind,  all of which are  hereby  expressly
waived by the Company and (ii)  additional  interest shall begin to accrue,  and
shall be considered  immediately due and payable, on the unpaid principal amount
of this Note at the rate of eighteen  percent (18%) per annum and shall continue
to accrue  until the  initial  interest  and  additional  interest  is paid.  In
addition,  the  Holder may take any action  available  to it under the  Purchase
Agreement or at law or in equity or by statute or otherwise.

         (b) No remedy herein conferred upon the Holder of this Note is intended
to be  exclusive  of any other  remedy and each and every such  remedy  shall be
cumulative and shall be in addition to every other remedy given hereunder or now
or hereafter existing at law or in equity or by statute or otherwise.


SECTION 9. NOTE REGISTER.

         (a) The Company shall keep at its principal executive office a register
(herein sometimes referred to as the "Note Register"), in which, subject to such
reasonable  regulations  as it may  prescribe,  but at its  expense  (other than
transfer  taxes,  if any),  the Company shall provide for the  registration  and
transfer of this Note.

         (b) Whenever this Note shall be surrendered at the principal  executive
office  of the  Company  for  transfer  or  exchange,  accompanied  by a written
instrument  of  transfer in form  reasonably  satisfactory  to the Company  duly
executed by the Holder  hereof or his attorney duly  authorized in writing,  the
Company shall execute and deliver in exchange  therefor a new Note or Notes,  as
may be requested by such Holder,  in the same aggregate  unpaid principal amount
and  payable  on the same date as the  principal  amount of the Note or Notes so
surrendered;  each such new Note shall be dated as of the date to which interest
has been paid on the unpaid principal amount of the Note or Notes so surrendered
and shall be in such  principal  amount and  registered in such name or names as
such Holder may designate in writing.

         (c) Upon receipt by the Company of evidence reasonably  satisfactory to
it of the loss,  theft,  destruction or mutilation of this Note and of indemnity
reasonably  satisfactory  to it, and upon  reimbursement  to the  Company of all
reasonable expenses  incidental thereto,  and upon surrender and cancellation of
this Note (in case of  mutilation)  the Company will make and deliver in lieu of
this Note a new Note of like tenor and unpaid  principal  amount and dated as of
the date to which interest has been paid on the unpaid  principal amount of this
Note in lieu of which such new Note is made and delivered.


SECTION 10. REGISTRATION UNDER SECURITIES ACT OF 1933.

         The Holder of this Note shall have  registration  rights as provided in
Section 8 of the Purchase Agreement,  with respect to the shares of Common Stock
underlying the Series D Preferred  Stock  issuable upon  conversion of the Notes
pursuant to the Optional and Default  Conversion  Right.  If the Holder is not a
party to the Purchase  Agreement,  by acceptance of this Note, the Holder agrees
to comply with  provisions  of Section 8 of the  Purchase  Agreement to the same
extent as if it were a party thereto.


SECTION 11. MISCELLANEOUS.

         (a)  Amendments  and Waivers.  The holders of sixty-six and  two-thirds
percent (66 2/3%) or more in principal amount of outstanding Notes of this issue
may waive or otherwise consent to the amendment of any of the provisions hereof,
provided that no such waiver or amendment may reduce the principal  amount of or
interest on any of the Notes of this issue or change the stated  maturity of the
principal or reduce the  percentage of holders of Notes of this issue  necessary
to waive or amend the  provisions  of this  Note,  without  the  consent of each
holder of any Note affected thereby.


                                       -9-


<PAGE>

         (b)  Restrictions on  Transferability.  In addition to the restrictions
set forth in Section 9(a) of this Note, the securities  represented by this Note
have  been  acquired  for  investment  and have not been  registered  under  the
Securities Act of 1933, as amended, or the securities laws of any state or other
jurisdiction.  Without  such  registration,  such  securities  may not be  sold,
pledged,  hypothecated or otherwise  transferred,  except pursuant to exemptions
from the Securities  Act of 1933, and the securities  laws of any state or other
jurisdiction.  Notwithstanding  the  above,  the  holder  of this  Note has been
provided  the  registration  rights  contained  in  Section  8 of  the  Purchase
Agreement with respect to the shares of the Company's  Common Stock which may be
acquired upon exercise of the Optional and Default Conversion Right.

         (c)  Forbearance  from  Suit.  No holder of Notes of this  issue  shall
institute any suit or proceeding for the enforcement of the payment of principal
or interest unless the holders of at least fifty-one  percent (51%) in principal
amount  of all of the  outstanding  Notes  of this  issue  join in such  suit or
proceeding.

         (d)  Governing  Law.  This Note shall be governed by and  construed  in
accordance  with the laws of the  State of New York,  excluding  the body of law
relating to conflict of laws. Notwithstanding anything to the contrary contained
herein, in no event may the effective rate of interest  collected or received by
the Holder exceed that which may be charged, collected or received by the Holder
under applicable law.

         (e) Interpretation. If any term or provision of this Note shall be held
invalid,  illegal  or  unenforceable,  the  validity  of  all  other  terms  and
provisions hereof shall in no way be affected thereby.

         (f) Successors and Assigns. This Note shall be binding upon the Company
and its  successors and assigns and shall inure to the benefit of the Holder and
its successors and assigns.

         (g) Notices. All notices, requests,  consents and demands shall be made
in writing and shall be mailed  postage  prepaid,  or delivered by hand,  to the
Company or to the Holder thereof at their  respective  addresses set forth below
or to such other  address  as may be  furnished  in  writing to the other  party
hereto:

                  If to the Holder:         At the address shown on Schedule A 
                                            attached hereto.

                  with a copy to:           Paramount Capital, Inc.
                                            787 Seventh Avenue
                                            New York, NY  10019
                                            Attn: David R. Walner

                  If to the Company:        Genta Incorporated
                                            3350 General Atomics Court
                                            San Diego, CA 92121
                                            Attention: Chief Executive Officer

         (h) Saturdays,  Sundays,  Holidays. If any date that may at any time be
specified  in this Note as a date for the making of any payment of  principal or
interest under this Note shall fall on Saturday, Sunday or on a day which in New
York  shall be a legal  holiday,  then the date for the  making of that  payment
shall be the  next  subsequent  day  which is not a  Saturday,  Sunday  or legal
holiday.

         (i) Purchase Agreement.  This Note is subject to the terms contained in
the  Purchase  Agreement  dated the date hereof  between the Company and certain
purchasers of the Senior Secured Convertible Bridge Notes and the holder of this
Note is entitled to the benefits of such Purchase Agreement and may, in addition
to any rights hereunder, enforce the agreements of the Company contained therein
and exercise the remedies provided for thereby or otherwise available in respect
thereof.


                                      -10-


<PAGE>

         IN WITNESS  WHEREOF,  this Note has been  executed  and  delivered as a
sealed  instrument  on the date  first  above  written  by the  duly  authorized
representative of the Company.


ATTEST:                             GENTA INCORPORATED


                                    By: /s/Thomas H. Adams
- --------------------                    -------------------------
                                    Name: Dr. Thomas H. Adams
                                    Its: President and Chief Executive Officer



(Corporate Seal)


                                      -11-


                                                                    EXHIBIT 10.5

THESE  SECURITIES HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933 OR
ANY APPLICABLE STATE  SECURITIES  LAWS. THEY MAY NOT BE SOLD,  OFFERED FOR SALE,
PLEDGED  OR  HYPOTHECATED   OR  OTHERWISE   TRANSFERRED  IN  THE  ABSENCE  OF  A
REGISTRATION  STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES  UNDER SUCH ACT
OR AN EXEMPTION  THEREFROM.  ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE
STATE SECURITIES LAWS.



                               GENTA INCORPORATED


              Class A Bridge Warrant for the Purchase of Shares of
                                  Common Stock


No. CA-1                                                        2,730,000 Shares


         FOR VALUE RECEIVED,  GENTA  INCORPORATED.,  a Delaware corporation (the
"COMPANY"),  hereby certifies that THE ARIES DOMESTIC FUND, LP or its registered
assigns (the "Holder") is entitled to purchase from the Company,  subject to the
provisions of this Warrant (the "Warrant"), at any time commencing upon the date
hereof (the  "INITIAL  EXERCISE  DATE"),  and prior to 5:00 P.M.,  New York City
time, on the date which is five (5) years from the date hereof (the "TERMINATION
DATE"),  2,730,000  fully paid and  non-assessable  shares of the Common  Stock,
$.001 par value, of the Company ("Common Stock"), at an exercise price of $0.001
per share of Common Stock for an aggregate  exercise price of TWO THOUSAND SEVEN
HUNDRED AND THIRTY DOLLARS ($2,730.00) (the aggregate purchase price payable for
the  Warrant  Shares  hereunder  is  hereinafter  sometimes  referred  to as the
"AGGREGATE EXERCISE PRICE"). The number of shares of Common Stock to be received
upon  exercise of this Warrant and the price to be paid for each share of Common
Stock are subject to possible  adjustment  from time to time as hereinafter  set
forth.  The shares of Common Stock or other  securities or property  deliverable
upon  such  exercise  as  adjusted  from time to time is  hereinafter  sometimes
referred to as the "WARRANT  SHARES."  The  exercise  price of a share of Common
Stock in effect  at any time and as  adjusted  from time to time is  hereinafter
sometimes  referred to as the "PER SHARE EXERCISE PRICE." The Per Share Exercise
Price is subject to adjustment as hereinafter provided; in the event of any such
adjustment,  the number of Warrant  Shares  shall be adjusted  by  dividing  the
Aggregate  Exercise Price by the Per Share Exercise Price in effect  immediately
after  such  adjustment.   The  Aggregate  Exercise  Price  is  not  subject  to
adjustment.

         1. EXERCISE OF WARRANT.

         (a) This Warrant may be  exercised in whole or in part,  at any time by
the Holder  commencing on the Initial Exercise Date and prior to the Termination
Date, by  presentation  and  surrender of this  Warrant,  together with the duly
executed  subscription form attached at the end hereof, at the address set forth
in subsection 8(a) hereof,  together with payment, by certified or official bank
check or wire  transfer  payable to the order of the Company,  of the  Aggregate
Exercise Price or the proportionate part thereof if exercised in part.

         (b) If this Warrant is exercised in part only, the Company shall,  upon
presentation of this Warrant upon such exercise, execute and deliver (along with
the certificate for the Warrant Shares  purchased) a new Warrant  evidencing the
rights of the  Holder  hereof to  purchase  the  balance of the  Warrant  Shares
purchasable  hereunder  upon the same terms and  conditions as herein set forth.
Upon  proper  exercise  of this  Warrant,  the Company  promptly  shall  deliver
certificates for the Warrant Shares to the Holder duly legended as authorized by
the subscription  form. No fractional  shares or scrip  representing  fractional
shares shall be issued upon exercise of this Warrant;  provided that the Company
shall pay to the holders of the Warrant cash in lieu of such fractional shares.


                                      -1-

<PAGE>

         2. RESERVATION OF WARRANT SHARES; FULLY PAID SHARES; TAXES. The Company
hereby  represents that it has, and until expiration of this Warrant agrees that
it shall,  reserve for issuance or delivery upon exercise of this Warrant,  such
number of shares of the Common Stock as shall be required  for  issuance  and/or
delivery  upon  exercise  of this  Warrant in full,  and agrees that all Warrant
Shares so  issued  and/or  delivered  will be  validly  issued,  fully  paid and
non-assessable,  and  further  agrees to pay all taxes and  charges  that may be
imposed upon such issuance and/or delivery.

         3. PROTECTION AGAINST DILUTION.

         (a) In the event the  Company  shall,  at any time or from time to time
after the date of issuance of this  Warrant,  issue or  distribute to all of the
holders of its shares of Common Stock  evidence of its  indebtedness,  any other
securities of the Company or any cash,  property or other assets (any such event
being herein called a "SPECIAL DIVIDEND"), the Per Share Exercise Price shall be
adjusted  by  multiplying  the Per  Share  Exercise  Price  then in  effect by a
fraction,  the  numerator  of which shall be the then  Current  Market Price (as
defined in paragraph  3(k) below) of the Common Stock,  less the Current  Market
Price of the Special  Dividend  issued or distributed in respect of one share of
Common Stock,  and the denominator of which shall be the Current Market Price of
the Common Stock.  Such adjustment  shall be made  successively  whenever such a
record  date  is  fixed.  Such  adjustment  shall  be  made  whenever  any  such
distribution  is made and shall become  effective  immediately  after the record
date  for  the   determination   of   shareholders   entitled  to  receive  such
distribution.

         (b) In case the Company  shall  hereafter  (i) pay a dividend or make a
distribution on its capital stock in shares of Common Stock,  (ii) subdivide its
outstanding  shares  of Common  Stock  into a greater  number of  shares,  (iii)
combine its  outstanding  shares of Common Stock into a smaller number of shares
or (iv)  issue by  reclassification  of its  Common  Stock any shares of capital
stock of the Company, the Per Share Exercise Price shall be adjusted to be equal
to a fraction,  the numerator of which shall be the Aggregate Exercise Price and
the  denominator of which shall be the number of shares of Common Stock or other
capital stock of the Company  issuable  upon  exercise of this Warrant  assuming
this Warrant had been exercised  immediately prior to such action. An adjustment
made pursuant to this subsection 3(b) shall become effective  immediately  after
the  record  date in the case of a dividend  or  distribution  and shall  become
effective  immediately  after the effective  date in the case of a  subdivision,
combination or reclassification.

         (c)(i) Except as provided in subsections 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share  (determined by dividing (i) the total amount,  if any, received
or  receivable by the Company in  consideration  of the issuance or sale of such
securities plus the consideration,  if any, payable to the Company upon exercise
or conversion  thereof  (collectively,  the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of Common  Stock  issued,  sold or  issuable  upon
exercise or conversion of such  securities)  which is less than the then Current
Market  Price of the Common  Stock (as defined  below) but not below the current
Per Share Exercise Price (which event is governed by subsection  3(c)(ii)),  the
Per Share  Exercise  Price shall be adjusted as of the date of such  issuance or
sale by  multiplying  the Per Share Exercise Price then in effect by a fraction,
the  numerator  of which  shall be (x) the sum of (A) the  number  of  shares of
Common Stock  outstanding  on the record date of such  issuance or sale plus (B)
the Total Consideration divided by the Current Market Price of the Common Stock,
and the  denominator  of which shall be (y) the number of shares of Common Stock
outstanding  on the record date of such issuance or sale plus the maximum number
of additional  shares of Common Stock issued,  sold or issuable upon exercise or
conversion of such securities.

         (c)(ii) Except as provided in subsection 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share (the  "ISSUE  PRICE"),  (determined  by  dividing  (i) the Total
Consideration  by (ii) the number of additional  


                                      -2-


<PAGE>

shares of Common Stock issuable upon exercise or conversion of such  securities)
which is less than the then  current Per Share  Exercise  Price in effect on the
record date of such issuance,  the Per Share Exercise Price shall be adjusted to
equal the Issue Price.

         (d) In the event of any capital reorganization or reclassification,  or
any  consolidation or merger to which the Company is a party other than a merger
or consolidation in which the Company is the continuing corporation,  or in case
of any sale or conveyance to another entity of the property of the Company as an
entirety  or  substantially  as an  entirety,  or in the  case of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Warrant  shall have the right  thereafter  to receive on the exercise of
this Warrant the kind and amount of securities, cash or other property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had this Warrant been  exercised  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 3 with respect to the rights and  interests  thereafter of
the  Holder of this  Warrant  to the end that the  provisions  set forth in this
Section 3 shall thereafter  correspondingly be made applicable, as nearly as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  exercise of this  Warrant.  The above
provisions  of  this   subsection  3(e)  shall  similarly  apply  to  successive
reorganizations,    reclassifications,    consolidations,   mergers,   statutory
exchanges,  sales or  conveyances.  The  issuer of any  shares of stock or other
securities or property  thereafter  deliverable  on the exercise of this Warrant
shall be responsible  for all of the  agreements and  obligations of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the  Warrants  not less
than 30 days  prior to such  event.  A sale of all or  substantially  all of the
assets of the Company for a  consideration  consisting  primarily of  securities
shall be deemed a consolidation or merger for the foregoing purposes.

         (e) In case any event shall occur as to which the other  provisions  of
this Section 3 are not strictly  applicable  but as to which the failure to make
any adjustment would not fairly protect the purchase rights  represented by this
Warrant in accordance with the essential  intent and principles  hereof then, in
each such case,  the  Holders of Warrants  representing  the right to purchase a
majority of the Warrant Shares subject to all outstanding Warrants may appoint a
firm  of  independent  public   accountants  of  recognized   national  standing
reasonably  acceptable to the Company,  which shall give their opinion as to the
adjustment,  if  any,  on a basis  consistent  with  the  essential  intent  and
principles  established  herein,  necessary  to  preserve  the  purchase  rights
represented  by the  Warrants.  Upon receipt of such  opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants shall be borne by the Company.

         (f) Whenever the Per Share Exercise Price payable upon exercise of each
Warrant is adjusted  pursuant to this  Section 3, the number of shares of Common
Stock underlying a Warrant shall  simultaneously be adjusted to equal the number
obtained by dividing  the  Aggregate  Exercise  Price by the  adjusted Per Share
Exercise Price.

         (g) No  adjustment  in the Per Share  Exercise  Price shall be required
unless such  adjustment  would require an increase or decrease of at least $0.01
per share of Common Stock;  provided,  however,  that any  adjustments  which by
reason of this  subsection  3(g) are not  required  to be made  shall be carried
forward and taken into account in any subsequent  adjustment.  All  calculations
under this Section 3 shall be made to the nearest cent or to the nearest 1/100th
of a share,  as the case may be.  Anything  in this  Section  3 to the  contrary
notwithstanding,  the Company  shall be entitled to make such  reductions in the
Per Share Exercise Price, in addition to those required by this Section 3, as it
in its discretion  shall deem to be advisable in order that any stock  dividend,
subdivision of shares or  distribution of rights to purchase stock or securities
convertible  or  exchangeable  for stock  hereafter  made by the  Company to its
stockholders shall not be taxable.


                                       -3-


<PAGE>

         (h)  Whenever the Per Share  Exercise  Price is adjusted as provided in
this Section 3 and upon any  modification  of the rights of a Holder of Warrants
in accordance  with this Section 3, the Company shall  promptly  obtain,  at its
expense, a certificate of a firm of independent public accountants of recognized
standing  selected by the Board of Directors (who may be the regular auditors of
the  Company)  setting  forth the Per  Share  Exercise  Price and the  number of
Warrant Shares after such adjustment or the effect of such modification, a brief
statement of the facts requiring such adjustment or modification  and the manner
of computing the same and cause copies of such  certificate  to be mailed to the
Holders of the Warrants.

         (i) If the Board of Directors of the Company shall declare any dividend
or other  distribution  with respect to the Common Stock, the Company shall mail
notice thereof to the Holders of the Warrants not less than 30 days prior to the
record date fixed for determining  stockholders  entitled to participate in such
dividend or other distribution.

         (j) If, as a result of an  adjustment  made pursuant to this Section 3,
the Holder of any Warrant  thereafter  surrendered  for  exercise  shall  become
entitled to receive  shares of two or more classes of capital stock or shares of
Common  Stock and other  capital  stock of the  Company,  the Board of Directors
(whose  determination  shall be  conclusive  and shall be described in a written
notice to the  Holder of any  Warrant  promptly  after  such  adjustment)  shall
determine  the  allocation of the adjusted Per Share  Exercise  Price between or
among  shares or such  classes  of capital  stock or shares of Common  Stock and
other capital stock.

         (k) For the purpose of any computation  under Section 3 above, the then
Current  Market Price per share (the "CURRENT  MARKET PRICE") shall be deemed to
be the last sale price of the Common Stock on the trading day prior to such date
or, in case no such  reported  sales take place on such day,  the average of the
last  reported  bid and asked  prices of the Common Stock on such day, in either
case on the principal national  securities exchange on which the Common Stock is
admitted  to trading or listed,  or if not listed or  admitted to trading on any
such  exchange,  the  representative  closing  bid price of the Common  Stock as
reported by the National  Association  of  Securities  Dealers,  Inc.  Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined by agreement between the Company's Board of Directors,  on the one
part, and the Holders of Warrants  representing the right to purchase a majority
of the Warrant Shares subject to all outstanding  Warrants,  on the second part.
If the Board of Directors  and such Holders fail to agree on the Current  Market
Price  within 60 days of the date of the action  giving  rise to any  adjustment
pursuant to this Section 3, such Holders  shall be entitled to appoint a firm of
independent  public  accountants or appraisers of recognized  national  standing
reasonably acceptable to the Company,  which shall give their opinion as to such
Current  Market  Price on a basis  consistent  with  the  essential  intent  and
principles  established herein.  Upon receipt of such opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants or appraisers shall be borne by the Company.

         4. REGISTRATION UNDER SECURITIES ACT OF 1933. The resale of the Warrant
Shares shall be  registered on the Shelf  Registration  Statement (as defined in
Article 8 of the Note and Warrant Purchase Agreement (the "Purchase  Agreement")
dated as of January 28, 1997, by and among the Company, The Aries Fund, a Cayman
Island Trust, and The Aries Domestic Fund, L.P., a Delaware limited partnership)
and  certain   purchasers  and  the  Holder  of  this  Warrant  shall  have  the
registration rights as provided in Article 8 of the Purchase  Agreement.  If the
Holder is not a party to the Purchase  Agreement,  by acceptance of this Warrant
the  Holder  agrees to  comply  with  provisions  of  Article 8 of the  Purchase
Agreement to the same extent as if it were a party thereto.

         5. LIMITED TRANSFERABILITY.  This Warrant may not be sold, transferred,
assigned or  hypothecated by the Holder except in compliance with the provisions
of the Act and the  applicable  state  securities  "blue  sky"  laws,  and is so
transferable  only  upon the  books of the  Company  which it shall  cause to be
maintained for such purpose. The Company may treat the registered Holder of this
Warrant as he or it appears on the Company's books 


                                       -4-


<PAGE>

at any time as the Holder for all purposes.  The Company shall permit any Holder
of a Warrant  or his duly  authorized  attorney,  upon  written  request  during
ordinary  business  hours,  to inspect and copy or make  extracts from its books
showing  the  registered  holders of  Warrants.  All  Warrants  issued  upon the
transfer  or  assignment  of this  Warrant  will be dated  the same date as this
Warrant, and all rights of the holder thereof shall be identical to those of the
Holder.

         6. LOSS, ETC., OF WARRANT. Upon receipt of evidence satisfactory to the
Company of the loss,  theft,  destruction or mutilation of this Warrant,  and of
indemnity reasonably  satisfactory to the Company, if lost, stolen or destroyed,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall  execute and  deliver to the Holder a new Warrant of like date,  tenor and
denomination.

         7. STATUS OF HOLDER.  This  Warrant does not confer upon the Holder any
right  to vote or to  consent  to or  receive  notice  as a  stockholder  of the
Company, as such, in respect of any matters  whatsoever,  or any other rights or
liabilities as a stockholder, prior to the exercise hereof.

         8. NOTICES.  No notice or other  communication under this Warrant shall
be effective unless,  but any notice or other  communication  shall be effective
and shall be deemed to have been given if, the same is in writing  and is mailed
by first-class mail, postage prepaid, addressed to:

          (a) the  Company  at  3550  General  Atomic  Corporation,  San  Diego,
          California 92121, Attention: Thomas H. Adams, or such other address as
          the Company has designated in writing to the Holder; or

          (b) the Holder at the address  indicated in the notice  provisions  to
          the  Purchase  Agreement,  or other  such  address  as the  Holder has
          designated in writing to the Company.

         9. OPTIONAL  CONVERSION.  Each warrant shall be convertible  into a New
Warrant (as  hereinafter  defined) on a one for one basis.  "New Warrants" shall
mean a new class of warrants  entitling the holders thereof to purchase,  at any
time on or before  the date which is five (5) years  from the date  hereof,  one
share of Common Stock at an exercise price equal to the lesser of (a) $0.15, and
(b) fifty percent (50%) of the average closing bid price of the Common Stock for
either (i) the thirty (30) consecutive  trading days immediately  succeeding the
date of the Required Shareholder Approval, if any (the "Approval Date"), or (ii)
the five (5) consecutive  trading days preceding the Approval Date if any. Other
than the exercise price, the New Warrants shall have the same terms as the Class
A  Warrants.  To the  extent  that  there is no  Required  Shareholder  Approval
necessary the foregoing clause (b) shall ignored.

         Notwithstanding  the foregoing,  the New Warrants' exercise price shall
be  adjusted at the time of the Final  Closing  Date (as that term is defined in
the Letter between Genta and Paramount  Capital Inc., dated January 28, 1997) if
the exercise price of the Offering  Warrants (as defined below) is less than the
exercise  price of the New  Warrants.  In such event the New  Warrants  exercise
price shall be reduced to equal 50% of the then  current  exercise  price of the
Offering  Warrants (as hereafter  defined).  "Offering  Warrants" shall mean the
warrants  described  in  paragraph  7 of the  Letter  between  the  Company  and
Paramount Capital, Inc. dated January 28, 1997.

         "Required  Shareholder  Approval"  shall  mean  the  authorization  and
approval  by the holders of the Common  Stock of the Company of the  issuance of
the shares of Common Stock underlying the Company's  Senior Secured  Convertible
Bridge Notes, to the extent such authorization is required pursuant to the rules
of the Nasdaq National Market or any other statute, rule or regulation.

         10.  HEADINGS.  The headings of this  Warrant  have been  inserted as a
matter of convenience and shall not affect the construction hereof.

         11.  APPLICABLE LAW. This Warrant shall be governed by and construed in
accordance  with the law of the  State  of New York  without  giving  effect  to
principles of conflicts of law thereof.


                                       -5-


<PAGE>

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its Chief  Executive  Officer and its corporate seal to be hereunto  affixed and
attested by its Secretary this January 28, 1997


                                        GENTA INCORPORATED



                                        By: /s/Thomas H. Adams
                                            ----------------------
                                               Name: Thomas H. Adams
                                               Title:    Chairman


ATTEST:



- --------------------
     Secretary



[Corporate Seal]


                                       -6-


<PAGE>

                                  SUBSCRIPTION

         The   undersigned,   ____________________________,   pursuant   to  the
provisions  of the  foregoing  Warrant,  hereby  elects to  exercise  the within
Warrant to the extent of purchasing _____________________ shares of Common Stock
thereunder and hereby makes payment of $_______________ by certified or official
bank check in payment of the exercise price therefor.

Dated:_______________                    Signature:_____________________________

                                         Address:_______________________________


                                   ASSIGNMENT

         FOR  VALUE  RECEIVED   _______________________________________   hereby
sells,  assigns and  transfers  unto  _____________________________________  the
foregoing  Warrant  and all  rights  evidenced  thereby,  and  does  irrevocably
constitute and appoint _____________________________, attorney, to transfer said
Warrant on the books of Genta, Inc.


Dated:_______________                    Signature:_____________________________

                                         Address:______________________________


                               PARTIAL ASSIGNMENT

         FOR  VALUE  RECEIVED   __________________________  hereby  assigns  and
transfers unto _________________________ the right to purchase __________ shares
of the Common  Stock,  no par value per  share,  of Genta,  Inc.  covered by the
foregoing  Warrant,  and a  proportionate  part of said  Warrant  and the rights
evidenced    thereby,    and   does    irrevocably    constitute   and   appoint
__________________________,  attorney,  to transfer that part of said Warrant on
the books of Genta, Inc.


Dated:_______________                    Signature:___________________________

                                         Address:_____________________________


                                       -7-



                                                                    EXHIBIT 10.6

THESE  SECURITIES HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933 OR
ANY APPLICABLE STATE  SECURITIES  LAWS. THEY MAY NOT BE SOLD,  OFFERED FOR SALE,
PLEDGED  OR  HYPOTHECATED   OR  OTHERWISE   TRANSFERRED  IN  THE  ABSENCE  OF  A
REGISTRATION  STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES  UNDER SUCH ACT
OR AN EXEMPTION  THEREFROM.  ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE
STATE SECURITIES LAWS.



                               GENTA INCORPORATED


              Class A Bridge Warrant for the Purchase of Shares of
                                  Common Stock


No. CA-2                                                        5,070,000 Shares


         FOR VALUE RECEIVED,  GENTA  INCORPORATED.,  a Delaware corporation (the
"COMPANY"), hereby certifies that THE ARIES TRUST or its registered assigns (the
"Holder") is entitled to purchase from the Company, subject to the provisions of
this Warrant (the  "Warrant"),  at any time commencing upon the date hereof (the
"INITIAL  EXERCISE  DATE"),  and prior to 5:00 P.M.,  New York City time, on the
date  which is five (5) years from the date  hereof  (the  "TERMINATION  DATE"),
5,070,000 fully paid and  non-assessable  shares of the Common Stock,  $.001 par
value, of the Company ("Common Stock"), at an exercise price of $0.001 per share
of Common Stock for an aggregate exercise price of FIVE THOUSAND SEVENTY DOLLARS
($5,070.00)  (the  aggregate  purchase  price  payable  for the  Warrant  Shares
hereunder  is  hereinafter  sometimes  referred  to as the  "AGGREGATE  EXERCISE
PRICE").  The number of shares of Common Stock to be received  upon  exercise of
this Warrant and the price to be paid for each share of Common Stock are subject
to possible adjustment from time to time as hereinafter set forth. The shares of
Common Stock or other  securities or property  deliverable upon such exercise as
adjusted from time to time is hereinafter  sometimes referred to as the "WARRANT
SHARES." The exercise price of a share of Common Stock in effect at any time and
as adjusted from time to time is hereinafter  sometimes  referred to as the "PER
SHARE EXERCISE  PRICE." The Per Share Exercise Price is subject to adjustment as
hereinafter provided; in the event of any such adjustment, the number of Warrant
Shares shall be adjusted by dividing  the  Aggregate  Exercise  Price by the Per
Share Exercise Price in effect immediately after such adjustment.  The Aggregate
Exercise Price is not subject to adjustment.

          1. EXERCISE OF WARRANT.

         (a) This Warrant may be  exercised in whole or in part,  at any time by
the Holder  commencing on the Initial Exercise Date and prior to the Termination
Date, by  presentation  and  surrender of this  Warrant,  together with the duly
executed  subscription form attached at the end hereof, at the address set forth
in subsection 8(a) hereof,  together with payment, by certified or official bank
check or wire  transfer  payable to the order of the Company,  of the  Aggregate
Exercise Price or the proportionate part thereof if exercised in part.

         (b) If this Warrant is exercised in part only, the Company shall,  upon
presentation of this Warrant upon such exercise, execute and deliver (along with
the certificate for the Warrant Shares  purchased) a new Warrant  evidencing the
rights of the  Holder  hereof to  purchase  the  balance of the  Warrant  Shares
purchasable  hereunder  upon the same terms and  conditions as herein set forth.
Upon  proper  exercise  of this  Warrant,  the Company  promptly  shall  deliver
certificates for the Warrant Shares to the Holder duly legended as authorized by
the subscription  form. No fractional  shares or scrip  representing  fractional
shares shall be issued upon exercise of this Warrant;  provided that the Company
shall pay to the holders of the Warrant cash in lieu of such fractional shares.


                                      -1-


<PAGE>

         2. RESERVATION OF WARRANT SHARES; FULLY PAID SHARES; TAXES. The Company
hereby  represents that it has, and until expiration of this Warrant agrees that
it shall,  reserve for issuance or delivery upon exercise of this Warrant,  such
number of shares of the Common Stock as shall be required  for  issuance  and/or
delivery  upon  exercise  of this  Warrant in full,  and agrees that all Warrant
Shares so  issued  and/or  delivered  will be  validly  issued,  fully  paid and
non-assessable,  and  further  agrees to pay all taxes and  charges  that may be
imposed upon such issuance and/or delivery.

         3. PROTECTION AGAINST DILUTION.

         (a) In the event the  Company  shall,  at any time or from time to time
after the date of issuance of this  Warrant,  issue or  distribute to all of the
holders of its shares of Common Stock  evidence of its  indebtedness,  any other
securities of the Company or any cash,  property or other assets (any such event
being herein called a "SPECIAL DIVIDEND"), the Per Share Exercise Price shall be
adjusted  by  multiplying  the Per  Share  Exercise  Price  then in  effect by a
fraction,  the  numerator  of which shall be the then  Current  Market Price (as
defined in paragraph  3(k) below) of the Common Stock,  less the Current  Market
Price of the Special  Dividend  issued or distributed in respect of one share of
Common Stock,  and the denominator of which shall be the Current Market Price of
the Common Stock.  Such adjustment  shall be made  successively  whenever such a
record  date  is  fixed.  Such  adjustment  shall  be  made  whenever  any  such
distribution  is made and shall become  effective  immediately  after the record
date  for  the   determination   of   shareholders   entitled  to  receive  such
distribution.

         (b) In case the Company  shall  hereafter  (i) pay a dividend or make a
distribution on its capital stock in shares of Common Stock,  (ii) subdivide its
outstanding  shares  of Common  Stock  into a greater  number of  shares,  (iii)
combine its  outstanding  shares of Common Stock into a smaller number of shares
or (iv)  issue by  reclassification  of its  Common  Stock any shares of capital
stock of the Company, the Per Share Exercise Price shall be adjusted to be equal
to a fraction,  the numerator of which shall be the Aggregate Exercise Price and
the  denominator of which shall be the number of shares of Common Stock or other
capital stock of the Company  issuable  upon  exercise of this Warrant  assuming
this Warrant had been exercised  immediately prior to such action. An adjustment
made pursuant to this subsection 3(b) shall become effective  immediately  after
the  record  date in the case of a dividend  or  distribution  and shall  become
effective  immediately  after the effective  date in the case of a  subdivision,
combination or reclassification.

         (c)(i) Except as provided in subsections 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share  (determined by dividing (i) the total amount,  if any, received
or  receivable by the Company in  consideration  of the issuance or sale of such
securities plus the consideration,  if any, payable to the Company upon exercise
or conversion  thereof  (collectively,  the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of Common  Stock  issued,  sold or  issuable  upon
exercise or conversion of such  securities)  which is less than the then Current
Market  Price of the Common  Stock (as defined  below) but not below the current
Per Share Exercise Price (which event is governed by subsection  3(c)(ii)),  the
Per Share  Exercise  Price shall be adjusted as of the date of such  issuance or
sale by  multiplying  the Per Share Exercise Price then in effect by a fraction,
the  numerator  of which  shall be (x) the sum of (A) the  number  of  shares of
Common Stock  outstanding  on the record date of such  issuance or sale plus (B)
the Total Consideration divided by the Current Market Price of the Common Stock,
and the  denominator  of which shall be (y) the number of shares of Common Stock
outstanding  on the record date of such issuance or sale plus the maximum number
of additional  shares of Common Stock issued,  sold or issuable upon exercise or
conversion of such securities.

         (c)(ii) Except as provided in subsection 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share (the  "ISSUE  PRICE"),  (determined  by  dividing  (i) the Total
Consideration  by (ii) the number of additional  


                                      -2-


<PAGE>

shares of Common Stock issuable upon exercise or conversion of such  securities)
which is less than the then  current Per Share  Exercise  Price in effect on the
record date of such issuance,  the Per Share Exercise Price shall be adjusted to
equal the Issue Price.

         (d) In the event of any capital reorganization or reclassification,  or
any  consolidation or merger to which the Company is a party other than a merger
or consolidation in which the Company is the continuing corporation,  or in case
of any sale or conveyance to another entity of the property of the Company as an
entirety  or  substantially  as an  entirety,  or in the  case of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Warrant  shall have the right  thereafter  to receive on the exercise of
this Warrant the kind and amount of securities, cash or other property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had this Warrant been  exercised  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 3 with respect to the rights and  interests  thereafter of
the  Holder of this  Warrant  to the end that the  provisions  set forth in this
Section 3 shall thereafter  correspondingly be made applicable, as nearly as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  exercise of this  Warrant.  The above
provisions  of  this   subsection  3(e)  shall  similarly  apply  to  successive
reorganizations,    reclassifications,    consolidations,   mergers,   statutory
exchanges,  sales or  conveyances.  The  issuer of any  shares of stock or other
securities or property  thereafter  deliverable  on the exercise of this Warrant
shall be responsible  for all of the  agreements and  obligations of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the  Warrants  not less
than 30 days  prior to such  event.  A sale of all or  substantially  all of the
assets of the Company for a  consideration  consisting  primarily of  securities
shall be deemed a consolidation or merger for the foregoing purposes.

         (e) In case any event shall occur as to which the other  provisions  of
this Section 3 are not strictly  applicable  but as to which the failure to make
any adjustment would not fairly protect the purchase rights  represented by this
Warrant in accordance with the essential  intent and principles  hereof then, in
each such case,  the  Holders of Warrants  representing  the right to purchase a
majority of the Warrant Shares subject to all outstanding Warrants may appoint a
firm  of  independent  public   accountants  of  recognized   national  standing
reasonably  acceptable to the Company,  which shall give their opinion as to the
adjustment,  if  any,  on a basis  consistent  with  the  essential  intent  and
principles  established  herein,  necessary  to  preserve  the  purchase  rights
represented  by the  Warrants.  Upon receipt of such  opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants shall be borne by the Company.

         (f) Whenever the Per Share Exercise Price payable upon exercise of each
Warrant is adjusted  pursuant to this  Section 3, the number of shares of Common
Stock underlying a Warrant shall  simultaneously be adjusted to equal the number
obtained by dividing  the  Aggregate  Exercise  Price by the  adjusted Per Share
Exercise Price.

         (g) No  adjustment  in the Per Share  Exercise  Price shall be required
unless such  adjustment  would require an increase or decrease of at least $0.01
per share of Common Stock;  provided,  however,  that any  adjustments  which by
reason of this  subsection  3(g) are not  required  to be made  shall be carried
forward and taken into account in any subsequent  adjustment.  All  calculations
under this Section 3 shall be made to the nearest cent or to the nearest 1/100th
of a share,  as the case may be.  Anything  in this  Section  3 to the  contrary
notwithstanding,  the Company  shall be entitled to make such  reductions in the
Per Share Exercise Price, in addition to those required by this Section 3, as it
in its discretion  shall deem to be advisable in order that any stock  dividend,
subdivision of shares or  distribution of rights to purchase stock or securities
convertible  or  exchangeable  for stock  hereafter  made by the  Company to its
stockholders shall not be taxable.


                                       -3-


<PAGE>

         (h)  Whenever the Per Share  Exercise  Price is adjusted as provided in
this Section 3 and upon any  modification  of the rights of a Holder of Warrants
in accordance  with this Section 3, the Company shall  promptly  obtain,  at its
expense, a certificate of a firm of independent public accountants of recognized
standing  selected by the Board of Directors (who may be the regular auditors of
the  Company)  setting  forth the Per  Share  Exercise  Price and the  number of
Warrant Shares after such adjustment or the effect of such modification, a brief
statement of the facts requiring such adjustment or modification  and the manner
of computing the same and cause copies of such  certificate  to be mailed to the
Holders of the Warrants.

         (i) If the Board of Directors of the Company shall declare any dividend
or other  distribution  with respect to the Common Stock, the Company shall mail
notice thereof to the Holders of the Warrants not less than 30 days prior to the
record date fixed for determining  stockholders  entitled to participate in such
dividend or other distribution.

         (j) If, as a result of an  adjustment  made pursuant to this Section 3,
the Holder of any Warrant  thereafter  surrendered  for  exercise  shall  become
entitled to receive  shares of two or more classes of capital stock or shares of
Common  Stock and other  capital  stock of the  Company,  the Board of Directors
(whose  determination  shall be  conclusive  and shall be described in a written
notice to the  Holder of any  Warrant  promptly  after  such  adjustment)  shall
determine  the  allocation of the adjusted Per Share  Exercise  Price between or
among  shares or such  classes  of capital  stock or shares of Common  Stock and
other capital stock.

         (k) For the purpose of any computation  under Section 3 above, the then
Current  Market Price per share (the "CURRENT  MARKET PRICE") shall be deemed to
be the last sale price of the Common Stock on the trading day prior to such date
or, in case no such  reported  sales take place on such day,  the average of the
last  reported  bid and asked  prices of the Common Stock on such day, in either
case on the principal national  securities exchange on which the Common Stock is
admitted  to trading or listed,  or if not listed or  admitted to trading on any
such  exchange,  the  representative  closing  bid price of the Common  Stock as
reported by the National  Association  of  Securities  Dealers,  Inc.  Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined by agreement between the Company's Board of Directors,  on the one
part, and the Holders of Warrants  representing the right to purchase a majority
of the Warrant Shares subject to all outstanding  Warrants,  on the second part.
If the Board of Directors  and such Holders fail to agree on the Current  Market
Price  within 60 days of the date of the action  giving  rise to any  adjustment
pursuant to this Section 3, such Holders  shall be entitled to appoint a firm of
independent  public  accountants or appraisers of recognized  national  standing
reasonably acceptable to the Company,  which shall give their opinion as to such
Current  Market  Price on a basis  consistent  with  the  essential  intent  and
principles  established herein.  Upon receipt of such opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants or appraisers shall be borne by the Company.

         4. REGISTRATION UNDER SECURITIES ACT OF 1933. The resale of the Warrant
Shares shall be  registered on the Shelf  Registration  Statement (as defined in
Article 8 of the Note and Warrant Purchase Agreement (the "Purchase  Agreement")
dated as of January 28, 1997, by and among the Company, The Aries Fund, a Cayman
Island Trust, and The Aries Domestic Fund, L.P., a Delaware limited partnership)
and  certain   purchasers  and  the  Holder  of  this  Warrant  shall  have  the
registration rights as provided in Article 8 of the Purchase  Agreement.  If the
Holder is not a party to the Purchase  Agreement,  by acceptance of this Warrant
the  Holder  agrees to  comply  with  provisions  of  Article 8 of the  Purchase
Agreement to the same extent as if it were a party thereto.

         5. LIMITED TRANSFERABILITY.  This Warrant may not be sold, transferred,
assigned or  hypothecated by the Holder except in compliance with the provisions
of the Act and the  applicable  state  securities  "blue  sky"  laws,  and is so
transferable  only  upon the  books of the  Company  which it shall  cause to be
maintained for such purpose. The Company may treat the registered Holder of this
Warrant as he or it appears on the Company's books 


                                       -4-


<PAGE>

at any time as the Holder for all purposes.  The Company shall permit any Holder
of a Warrant  or his duly  authorized  attorney,  upon  written  request  during
ordinary  business  hours,  to inspect and copy or make  extracts from its books
showing  the  registered  holders of  Warrants.  All  Warrants  issued  upon the
transfer  or  assignment  of this  Warrant  will be dated  the same date as this
Warrant, and all rights of the holder thereof shall be identical to those of the
Holder.

         6. LOSS, ETC., OF WARRANT. Upon receipt of evidence satisfactory to the
Company of the loss,  theft,  destruction or mutilation of this Warrant,  and of
indemnity reasonably  satisfactory to the Company, if lost, stolen or destroyed,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall  execute and  deliver to the Holder a new Warrant of like date,  tenor and
denomination.

         7. STATUS OF HOLDER.  This  Warrant does not confer upon the Holder any
right  to vote or to  consent  to or  receive  notice  as a  stockholder  of the
Company, as such, in respect of any matters  whatsoever,  or any other rights or
liabilities as a stockholder, prior to the exercise hereof.

         8. NOTICES.  No notice or other  communication under this Warrant shall
be effective unless,  but any notice or other  communication  shall be effective
and shall be deemed to have been given if, the same is in writing  and is mailed
by first-class mail, postage prepaid, addressed to:

          (a) the  Company  at  3550  General  Atomic  Corporation,  San  Diego,
          California 92121, Attention: Thomas H. Adams, or such other address as
          the Company has designated in writing to the Holder; or

          (b) the Holder at the address  indicated in the notice  provisions  to
          the  Purchase  Agreement,  or other  such  address  as the  Holder has
          designated in writing to the Company.

         9. OPTIONAL  CONVERSION.  Each warrant shall be convertible  into a New
Warrant (as  hereinafter  defined) on a one for one basis.  "New Warrants" shall
mean a new class of warrants  entitling the holders thereof to purchase,  at any
time on or before  the date which is five (5) years  from the date  hereof,  one
share of Common Stock at an exercise price equal to the lesser of (a) $0.15, and
(b) fifty percent (50%) of the average closing bid price of the Common Stock for
either (i) the thirty (30) consecutive  trading days immediately  succeeding the
date of the Required Shareholder Approval, if any (the "Approval Date"), or (ii)
the five (5) consecutive trading days preceding the Approval Date, if any. Other
than the exercise price, the New Warrants shall have the same terms as the Class
A  Warrants.  To the  extent  that  there is no  Required  Shareholder  Approval
necessary the foregoing clause (b) shall be ignored.

         Notwithstanding  the foregoing,  the New Warrants' exercise price shall
be  adjusted at the time of the Final  Closing  Date (as that term is defined in
the Letter between Genta and Paramount  Capital Inc., dated January 28, 1997) if
the exercise price of the Offering  Warrants (as defined below) is less than the
exercise  price of the New  Warrants.  In such event the New  Warrants  exercise
price shall be reduced to equal 50% of the then  current  exercise  price of the
Offering  Warrants (as hereafter  defined).  "Offering  Warrants" shall mean the
warrants  described  in  paragraph  7 of the  Letter  between  the  Company  and
Paramount Capital, Inc. dated January 28, 1997.

         "Required  Shareholder  Approval"  shall  mean  the  authorization  and
approval  by the holders of the Common  Stock of the Company of the  issuance of
the shares of Common Stock underlying the Company's  Senior Secured  Convertible
Bridge Notes, to the extent such authorization is required pursuant to the rules
of the Nasdaq National Market or any other statute, rule or regulation.

         10.  HEADINGS.  The headings of this  Warrant  have been  inserted as a
matter of convenience and shall not affect the construction hereof.

         11.  APPLICABLE LAW. This Warrant shall be governed by and construed in
accordance  with the law of the  State  of New York  without  giving  effect  to
principles of conflicts of law thereof.


                                       -5-


<PAGE>

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its Chief  Executive  Officer and its corporate seal to be hereunto  affixed and
attested by its Secretary this January 28, 1997


                                          GENTA INCORPORATED



                                          By: /s/Thomas H. Adams
                                              ----------------------
                                                  Name: Thomas H. Adams
                                                  Title:    Chairman


ATTEST:



- --------------------
     Secretary



[Corporate Seal]


                                       -6-


<PAGE>

                                  SUBSCRIPTION

         The   undersigned,   ____________________________,   pursuant   to  the
provisions  of the  foregoing  Warrant,  hereby  elects to  exercise  the within
Warrant to the extent of purchasing _____________________ shares of Common Stock
thereunder and hereby makes payment of $_______________ by certified or official
bank check in payment of the exercise price therefor.

Dated:_______________                    Signature:_____________________________

                                         Address:_______________________________


                                   ASSIGNMENT

         FOR  VALUE  RECEIVED   _______________________________________   hereby
sells,  assigns and  transfers  unto  _____________________________________  the
foregoing  Warrant  and all  rights  evidenced  thereby,  and  does  irrevocably
constitute and appoint _____________________________, attorney, to transfer said
Warrant on the books of Genta, Inc.


Dated:_______________                    Signature:_____________________________

                                         Address:______________________________


                               PARTIAL ASSIGNMENT

         FOR  VALUE  RECEIVED   __________________________  hereby  assigns  and
transfers unto _________________________ the right to purchase __________ shares
of the Common  Stock,  no par value per  share,  of Genta,  Inc.  covered by the
foregoing  Warrant,  and a  proportionate  part of said  Warrant  and the rights
evidenced    thereby,    and   does    irrevocably    constitute   and   appoint
__________________________,  attorney,  to transfer that part of said Warrant on
the books of Genta, Inc.


Dated:_______________                    Signature:___________________________

                                         Address:_____________________________


                                       -7-


                                                                    EXHIBIT 10.7

THESE  SECURITIES HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933 OR
ANY APPLICABLE STATE  SECURITIES  LAWS. THEY MAY NOT BE SOLD,  OFFERED FOR SALE,
PLEDGED  OR  HYPOTHECATED   OR  OTHERWISE   TRANSFERRED  IN  THE  ABSENCE  OF  A
REGISTRATION  STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES  UNDER SUCH ACT
OR AN EXEMPTION  THEREFROM.  ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE
STATE SECURITIES LAWS.



                               GENTA INCORPORATED


              Class B Bridge Warrant for the Purchase of Shares of
                                  Common Stock


No. CB-1                                                        4,270,000 Shares


         FOR VALUE RECEIVED,  GENTA  INCORPORATED.,  a Delaware corporation (the
"COMPANY"), hereby certifies that THE ARIES DOMESTIC FUND, LP, or its registered
assigns (the "Holder") is entitled to purchase from the Company,  subject to the
provisions of this Warrant (the "Warrant"), at any time commencing upon the date
hereof (the  "INITIAL  EXERCISE  DATE"),  and prior to 5:00 P.M.,  New York City
time, on the date which is five (5) years from the date hereof (the "TERMINATION
DATE"),  4,270,000  fully paid and  non-assessable  shares of the Common  Stock,
$.001 par value, of the Company ("Common Stock"),  at an exercise price equal to
$.55 per share of Common  Stock for an aggregate  exercise  price of TWO MILLION
THREE HUNDRED FORTY EIGHT  THOUSAND FIVE HUNDRED  DOLLARS  ($2,348,500.00)  (the
aggregate purchase price payable for the Warrant Shares hereunder is hereinafter
sometimes referred to as the "AGGREGATE  EXERCISE PRICE").  The number of shares
of Common Stock to be received upon exercise of this Warrant and the price to be
paid for each share of Common Stock are subject to possible adjustment from time
to time as hereinafter set forth. The shares of Common Stock or other securities
or property  deliverable  upon such  exercise  as adjusted  from time to time is
hereinafter sometimes referred to as the "WARRANT SHARES." The exercise price of
a share of Common Stock in effect at any time and as adjusted  from time to time
is hereinafter  sometimes referred to as the "PER SHARE EXERCISE PRICE." The Per
Share Exercise Price is subject to adjustment as  hereinafter  provided;  in the
event of any such adjustment,  the number of Warrant Shares shall be adjusted by
dividing the Aggregate  Exercise Price by the Per Share Exercise Price in effect
immediately after such adjustment.  The Aggregate  Exercise Price is not subject
to adjustment.

         1. EXERCISE OF WARRANT.

         (a) This Warrant may be  exercised in whole or in part,  at any time by
the Holder  commencing on the Initial Exercise Date and prior to the Termination
Date, by  presentation  and  surrender of this  Warrant,  together with the duly
executed  subscription form attached at the end hereof, at the address set forth
in subsection 8(a) hereof,  together with payment, by certified or official bank
check or wire  transfer  payable to the order of the Company,  of the  Aggregate
Exercise Price or the proportionate part thereof if exercised in part.

         (b) If this Warrant is exercised in part only, the Company shall,  upon
presentation of this Warrant upon such exercise, execute and deliver (along with
the certificate for the Warrant Shares  purchased) a new Warrant  evidencing the
rights of the  Holder  hereof to  purchase  the  balance of the  Warrant  Shares
purchasable  hereunder  upon the same terms and  conditions as herein set forth.
Upon  proper  exercise  of this  Warrant,  the Company  promptly  shall  deliver
certificates for the Warrant Shares to the Holder duly legended as authorized by
the subscription  form. No fractional  shares or scrip  representing  fractional
shares shall be issued upon exercise of this Warrant;  provided 


                                      -1-


<PAGE>

that the Company  shall pay to the  holders of the Warrant  cash in lieu of such
fractional shares.

         2. RESERVATION OF WARRANT SHARES; FULLY PAID SHARES; TAXES. The Company
hereby  represents that it has, and until expiration of this Warrant agrees that
it shall,  reserve for issuance or delivery upon exercise of this Warrant,  such
number of shares of the Common Stock as shall be required  for  issuance  and/or
delivery  upon  exercise  of this  Warrant in full,  and agrees that all Warrant
Shares so  issued  and/or  delivered  will be  validly  issued,  fully  paid and
non-assessable,  and  further  agrees to pay all taxes and  charges  that may be
imposed upon such issuance and/or delivery.

         3. PROTECTION AGAINST DILUTION.

         (a) In the event the  Company  shall,  at any time or from time to time
after the date of issuance of this  Warrant,  issue or  distribute to all of the
holders of its shares of Common Stock  evidence of its  indebtedness,  any other
securities of the Company or any cash,  property or other assets (any such event
being herein called a "SPECIAL DIVIDEND"), the Per Share Exercise Price shall be
adjusted  by  multiplying  the Per  Share  Exercise  Price  then in  effect by a
fraction,  the  numerator  of which shall be the then  Current  Market Price (as
defined in paragraph  3(k) below) of the Common Stock,  less the Current  Market
Price of the Special  Dividend  issued or distributed in respect of one share of
Common Stock,  and the denominator of which shall be the Current Market Price of
the Common Stock.  Such adjustment  shall be made  successively  whenever such a
record  date  is  fixed.  Such  adjustment  shall  be  made  whenever  any  such
distribution  is made and shall become  effective  immediately  after the record
date  for  the   determination   of   shareholders   entitled  to  receive  such
distribution.

         (b) In case the Company  shall  hereafter  (i) pay a dividend or make a
distribution on its capital stock in shares of Common Stock,  (ii) subdivide its
outstanding  shares  of Common  Stock  into a greater  number of  shares,  (iii)
combine its  outstanding  shares of Common Stock into a smaller number of shares
or (iv)  issue by  reclassification  of its  Common  Stock any shares of capital
stock of the Company,  the number of shares to be delivered upon exercise of any
share of this  Warrant  will be  appropriately  increased  so that each  Warrant
holder  thereafter  will be entitled to receive the number of Common Shares that
such holder would have owned immediately  following such action had such Warrant
been exercised  immediately prior thereto, and the Per Share Exercise Price will
be appropriately  adjusted.  An adjustment made pursuant to this subsection 3(b)
shall  become  effective  immediately  after  the  record  date in the case of a
dividend  or  distribution  and shall  become  effective  immediately  after the
effective date in the case of a subdivision, combination or reclassification.

         (c)(i) Except as provided in subsections 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share  (determined by dividing (i) the total amount,  if any, received
or  receivable by the Company in  consideration  of the issuance or sale of such
securities plus the consideration,  if any, payable to the Company upon exercise
or conversion  thereof  (collectively,  the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of Common  Stock  issued,  sold or  issuable  upon
exercise or conversion of such  securities)  which is less than the then Current
Market  Price of the Common  Stock (as defined  below) but not below the current
Per Share Exercise Price (which event is governed by subsection  3(c)(ii)),  the
Per Share  Exercise  Price shall be adjusted as of the date of such  issuance or
sale by  multiplying  the Per Share Exercise Price then in effect by a fraction,
the  numerator  of which  shall be (x) the sum of (A) the  number  of  shares of
Common Stock  outstanding  on the record date of such  issuance or sale plus (B)
the Total Consideration divided by the Current Market Price of the Common Stock,
and the  denominator  of which shall be (y) the number of shares of Common Stock
outstanding  on the record date of such issuance or sale plus the maximum number
of additional  shares of Common Stock issued,  sold or issuable upon exercise or
conversion of such securities.

         (c)(ii) Except as provided in subsection 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or


                                       -2-


<PAGE>

securities  convertible into Common Stock, in each case for a price per share or
entitling the holders thereof to purchase Common Stock at a price per share (the
"ISSUE PRICE"),  (determined by dividing (i) the Total Consideration by (ii) the
number of additional shares of Common Stock issuable upon exercise or conversion
of such securities) which is less than the then current Per Share Exercise Price
in effect on the record  date of such  issuance,  the Per Share  Exercise  Price
shall be adjusted to equal the Issue Price.

         (d) In the event of any capital reorganization or reclassification,  or
any  consolidation or merger to which the Company is a party other than a merger
or consolidation in which the Company is the continuing corporation,  or in case
of any sale or conveyance to another entity of the property of the Company as an
entirety  or  substantially  as an  entirety,  or in the  case of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Warrant  shall have the right  thereafter  to receive on the exercise of
this Warrant the kind and amount of securities, cash or other property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had this Warrant been  exercised  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 3 with respect to the rights and  interests  thereafter of
the  Holder of this  Warrant  to the end that the  provisions  set forth in this
Section 3 shall thereafter  correspondingly be made applicable, as nearly as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  exercise of this  Warrant.  The above
provisions  of  this   subsection  3(e)  shall  similarly  apply  to  successive
reorganizations,    reclassifications,    consolidations,   mergers,   statutory
exchanges,  sales or  conveyances.  The  issuer of any  shares of stock or other
securities or property  thereafter  deliverable  on the exercise of this Warrant
shall be responsible  for all of the  agreements and  obligations of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the  Warrants  not less
than 30 days  prior to such  event.  A sale of all or  substantially  all of the
assets of the Company for a  consideration  consisting  primarily of  securities
shall be deemed a consolidation or merger for the foregoing purposes.

         (e) In case any event shall occur as to which the other  provisions  of
this Section 3 are not strictly  applicable  but as to which the failure to make
any adjustment would not fairly protect the purchase rights  represented by this
Warrant in accordance with the essential  intent and principles  hereof then, in
each such case,  the  Holders of Warrants  representing  the right to purchase a
majority of the Warrant Shares subject to all outstanding Warrants may appoint a
firm  of  independent  public   accountants  of  recognized   national  standing
reasonably  acceptable to the Company,  which shall give their opinion as to the
adjustment,  if  any,  on a basis  consistent  with  the  essential  intent  and
principles  established  herein,  necessary  to  preserve  the  purchase  rights
represented  by the  Warrants.  Upon receipt of such  opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants shall be borne by the Company.

         (f) Whenever the Per Share Exercise Price payable upon exercise of each
Warrant is adjusted  pursuant to this  Section 3, the number of shares of Common
Stock underlying a Warrant shall  simultaneously be adjusted to equal the number
obtained by dividing  the  Aggregate  Exercise  Price by the  adjusted Per Share
Exercise Price.

         (g) No  adjustment  in the Per Share  Exercise  Price shall be required
unless such  adjustment  would require an increase or decrease of at least $0.01
per share of Common Stock;  provided,  however,  that any  adjustments  which by
reason of this  subsection  3(g) are not  required  to be made  shall be carried
forward and taken into account in any subsequent  adjustment.  All  calculations
under this Section 3 shall be made to the nearest cent or to the nearest 1/100th
of a share,  as the case may be.  Anything  in this  Section  3 to the  contrary
notwithstanding,  the Company  shall be entitled to make such  reductions in the
Per Share Exercise Price, in addition to those required by this Section 3, as it
in its discretion  shall deem to be advisable in order that any stock  dividend,
subdivision of shares or  distribution of rights to purchase stock or securities
convertible  or  


                                       -3-


<PAGE>

exchangeable for stock hereafter made by the Company to its  stockholders  shall
not be taxable.

         (h)  Whenever the Per Share  Exercise  Price is adjusted as provided in
this Section 3 and upon any  modification  of the rights of a Holder of Warrants
in accordance  with this Section 3, the Company shall  promptly  obtain,  at its
expense, a certificate of a firm of independent public accountants of recognized
standing  selected by the Board of Directors (who may be the regular auditors of
the  Company)  setting  forth the Per  Share  Exercise  Price and the  number of
Warrant Shares after such adjustment or the effect of such modification, a brief
statement of the facts requiring such adjustment or modification  and the manner
of computing the same and cause copies of such  certificate  to be mailed to the
Holders of the Warrants.

         (i) If the Board of Directors of the Company shall declare any dividend
or other  distribution  with respect to the Common Stock, the Company shall mail
notice thereof to the Holders of the Warrants not less than 30 days prior to the
record date fixed for determining  stockholders  entitled to participate in such
dividend or other distribution.

         (j) If, as a result of an  adjustment  made pursuant to this Section 3,
the Holder of any Warrant  thereafter  surrendered  for  exercise  shall  become
entitled to receive  shares of two or more classes of capital stock or shares of
Common  Stock and other  capital  stock of the  Company,  the Board of Directors
(whose  determination  shall be  conclusive  and shall be described in a written
notice to the  Holder of any  Warrant  promptly  after  such  adjustment)  shall
determine  the  allocation of the adjusted Per Share  Exercise  Price between or
among  shares or such  classes  of capital  stock or shares of Common  Stock and
other capital stock.

         (k) For the purpose of any computation  under Section 3 above, the then
Current  Market Price per share (the "CURRENT  MARKET PRICE") shall be deemed to
be the last sale price of the Common Stock on the trading day prior to such date
or, in case no such  reported  sales take place on such day,  the average of the
last  reported  bid and asked  prices of the Common Stock on such day, in either
case on the principal national  securities exchange on which the Common Stock is
admitted  to trading or listed,  or if not listed or  admitted to trading on any
such  exchange,  the  representative  closing  bid price of the Common  Stock as
reported by the National  Association  of  Securities  Dealers,  Inc.  Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined by agreement between the Company's Board of Directors,  on the one
part, and the Holders of Warrants  representing the right to purchase a majority
of the Warrant Shares subject to all outstanding  Warrants,  on the second part.
If the Board of Directors  and such Holders fail to agree on the Current  Market
Price  within 60 days of the date of the action  giving  rise to any  adjustment
pursuant to this Section 3, such Holders  shall be entitled to appoint a firm of
independent  public  accountants or appraisers of recognized  national  standing
reasonably acceptable to the Company,  which shall give their opinion as to such
Current  Market  Price on a basis  consistent  with  the  essential  intent  and
principles  established herein.  Upon receipt of such opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants or appraisers shall be borne by the Company.

         4. REGISTRATION UNDER SECURITIES ACT OF 1933. The resale of the Warrant
Shares shall be  registered on the Shelf  Registration  Statement (as defined in
Article 8 of the Note and Warrant Purchase Agreement (the "Purchase  Agreement")
dated as of January 28, 1997, by and among the Company, The Aries Fund, a Cayman
Island Trust, and The Aries Domestic Fund, L.P., a Delaware limited partnership)
and  certain   purchasers  and  the  Holder  of  this  Warrant  shall  have  the
registration rights as provided in Article 8 of the Purchase  Agreement.  If the
Holder is not a party to the Purchase  Agreement,  by acceptance of this Warrant
the  Holder  agrees to  comply  with  provisions  of  Article 8 of the  Purchase
Agreement to the same extent as if it were a party thereto.

         5. LIMITED TRANSFERABILITY.  This Warrant may not be sold, transferred,
assigned or  hypothecated by the Holder except in compliance with the provisions
of the Act 


                                       -4-


<PAGE>

and the applicable state securities "blue sky" laws, and is so transferable only
upon the books of the  Company  which it shall cause to be  maintained  for such
purpose. The Company may treat the registered Holder of this Warrant as he or it
appears on the Company's  books at any time as the Holder for all purposes.  The
Company  shall permit any Holder of a Warrant or his duly  authorized  attorney,
upon written request during ordinary business hours, to inspect and copy or make
extracts from its books showing the registered holders of Warrants. All Warrants
issued upon the  transfer or  assignment  of this Warrant will be dated the same
date as this Warrant, and all rights of the holder thereof shall be identical to
those of the Holder.

         6. LOSS, ETC., OF WARRANT. Upon receipt of evidence satisfactory to the
 Company of the loss, theft, destruction or mutilation of this Warrant, and of
indemnity reasonably  satisfactory to the Company, if lost, stolen or destroyed,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall  execute and  deliver to the Holder a new Warrant of like date,  tenor and
denomination.

         7. STATUS OF HOLDER.  This  Warrant does not confer upon the Holder any
right  to vote or to  consent  to or  receive  notice  as a  stockholder  of the
Company, as such, in respect of any matters  whatsoever,  or any other rights or
liabilities as a stockholder, prior to the exercise hereof.

         8. NOTICES.  No notice or other  communication under this Warrant shall
be effective unless,  but any notice or other  communication  shall be effective
and shall be deemed to have been given if, the same is in writing  and is mailed
by first-class mail, postage prepaid, addressed to:

          (a) the  Company  at  3550  General  Atomic  Corporation,  San  Diego,
          California 92121, Attention: Thomas H. Adams, or such other address as
          the Company has designated in writing to the Holder; or

          (b) the Holder at the address  indicated in the notice  provisions  to
          the  Purchase  Agreement,  or other  such  address  as the  Holder has
          designated in writing to the Company.

         9. OPTIONAL  CONVERSION.  Each warrant shall be convertible  into a New
Warrant (as  hereinafter  defined) on a one for one basis.  "New Warrants" shall
mean a new class of warrants  entitling the holders thereof to purchase,  at any
time on or before  the date which is five (5) years  from the date  hereof,  one
share of Common Stock at an exercise price equal to the lesser of (a) $0.15, and
(b) fifty percent (50%) of the average closing bid price of the Common Stock for
either (i) the thirty (30) consecutive  trading days immediately  succeeding the
date of the Required Shareholder Approval, if any (the "Approval Date"), or (ii)
the five (5) consecutive trading days preceding the Approval Date, if any. Other
than the exercise price, the New Warrants shall have the same terms as the Class
A  Warrants.  To the  extent  that  there is no  Required  Shareholder  Approval
necessary the foregoing clause (b) shall be ignored.

         Notwithstanding  the foregoing,  the New Warrants' exercise price shall
be  adjusted at the time of the Final  Closing  Date (as that term is defined in
the Letter between Genta and Paramount  Capital Inc., dated January 28, 1997) if
the exercise price of the Offering  Warrants (as defined below) is less than the
exercise  price of the New  Warrants.  In such event the New  Warrants  exercise
price shall be reduced to equal 50% of the then  current  exercise  price of the
Offering  Warrants (as hereafter  defined).  "Offering  Warrants" shall mean the
warrants  described  in  paragraph  7 of the  Letter  between  the  Company  and
Paramount Capital, Inc. dated January 28, 1997.

         "Required  Shareholder  Approval"  shall  mean  the  authorization  and
approval  by the holders of the Common  Stock of the Company of the  issuance of
the shares of Common Stock underlying the Company's  Senior Secured  Convertible
Bridge Notes, to the extent such authorization is required pursuant to the rules
of the Nasdaq National Market or any other statute, rule or regulation.

         10.  HEADINGS.  The headings of this  Warrant  have been  inserted as a
matter of convenience and shall not affect the construction hereof.


                                       -5-


<PAGE>

         11.  APPLICABLE LAW. This Warrant shall be governed by and construed in
accordance  with the law of the  State  of New York  without  giving  effect  to
principles of conflicts of law thereof.

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its Chief  Executive  Officer and its corporate seal to be hereunto  affixed and
attested by its Secretary this January 28, 1997


                                     GENTA INCORPORATED



                                     By: /s/Thomas H. Adams
                                         ----------------------
                                            Name: Thomas H. Adams
                                            Title:    President and CEO


ATTEST:



- --------------------
     Secretary



[Corporate Seal]


                                       -6-


<PAGE>


                                  SUBSCRIPTION

         The   undersigned,   ____________________________,   pursuant   to  the
provisions  of the  foregoing  Warrant,  hereby  elects to  exercise  the within
Warrant to the extent of purchasing _____________________ shares of Common Stock
thereunder and hereby makes payment of $_______________ by certified or official
bank check in payment of the exercise price therefor.

Dated:_______________                    Signature:_____________________________

                                         Address:_______________________________


                                   ASSIGNMENT

         FOR  VALUE  RECEIVED   _______________________________________   hereby
sells,  assigns and  transfers  unto  _____________________________________  the
foregoing  Warrant  and all  rights  evidenced  thereby,  and  does  irrevocably
constitute and appoint _____________________________, attorney, to transfer said
Warrant on the books of Genta, Inc.


Dated:_______________                    Signature:_____________________________

                                         Address:______________________________


                               PARTIAL ASSIGNMENT

         FOR  VALUE  RECEIVED   __________________________  hereby  assigns  and
transfers unto _________________________ the right to purchase __________ shares
of the Common  Stock,  no par value per  share,  of Genta,  Inc.  covered by the
foregoing  Warrant,  and a  proportionate  part of said  Warrant  and the rights
evidenced    thereby,    and   does    irrevocably    constitute   and   appoint
__________________________,  attorney,  to transfer that part of said Warrant on
the books of Genta, Inc.


Dated:_______________                    Signature:___________________________

                                         Address:_____________________________


                                       -7-



                                                                    EXHIBIT 10.8

THESE  SECURITIES HAVE NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933 OR
ANY APPLICABLE STATE  SECURITIES  LAWS. THEY MAY NOT BE SOLD,  OFFERED FOR SALE,
PLEDGED  OR  HYPOTHECATED   OR  OTHERWISE   TRANSFERRED  IN  THE  ABSENCE  OF  A
REGISTRATION  STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES  UNDER SUCH ACT
OR AN EXEMPTION  THEREFROM.  ANY SUCH TRANSFER MAY ALSO BE SUBJECT TO APPLICABLE
STATE SECURITIES LAWS.



                               GENTA INCORPORATED


              Class B Bridge Warrant for the Purchase of Shares of
                                  Common Stock


No. CB-2                                                        7,930,000 Shares


         FOR VALUE RECEIVED,  GENTA  INCORPORATED.,  a Delaware corporation (the
"COMPANY"),  hereby  certifies that THE ARIES TRUST,  or its registered  assigns
(the  "Holder")  is  entitled  to  purchase  from the  Company,  subject  to the
provisions of this Warrant (the "Warrant"), at any time commencing upon the date
hereof (the  "INITIAL  EXERCISE  DATE"),  and prior to 5:00 P.M.,  New York City
time, on the date which is five (5) years from the date hereof (the "TERMINATION
DATE"),  7,930,000  fully paid and  non-assessable  shares of the Common  Stock,
$.001 par value, of the Company ("Common Stock"),  at an exercise price equal to
$.55 per share of Common Stock for an aggregate  exercise  price of FOUR MILLION
THREE  HUNDRED SIXTY ONE FIVE HUNDRED  DOLLARS  ($4,361,500.00)  (the  aggregate
purchase price payable for the Warrant Shares hereunder is hereinafter sometimes
referred to as the "AGGREGATE  EXERCISE PRICE").  The number of shares of Common
Stock to be received  upon exercise of this Warrant and the price to be paid for
each share of Common Stock are subject to possible  adjustment from time to time
as  hereinafter  set forth.  The shares of Common Stock or other  securities  or
property  deliverable  upon  such  exercise  as  adjusted  from  time to time is
hereinafter sometimes referred to as the "WARRANT SHARES." The exercise price of
a share of Common Stock in effect at any time and as adjusted  from time to time
is hereinafter  sometimes referred to as the "PER SHARE EXERCISE PRICE." The Per
Share Exercise Price is subject to adjustment as  hereinafter  provided;  in the
event of any such adjustment,  the number of Warrant Shares shall be adjusted by
dividing the Aggregate  Exercise Price by the Per Share Exercise Price in effect
immediately after such adjustment.  The Aggregate  Exercise Price is not subject
to adjustment.

         1. EXERCISE OF WARRANT.

         (a) This Warrant may be  exercised in whole or in part,  at any time by
the Holder  commencing on the Initial Exercise Date and prior to the Termination
Date, by  presentation  and  surrender of this  Warrant,  together with the duly
executed  subscription form attached at the end hereof, at the address set forth
in subsection 8(a) hereof,  together with payment, by certified or official bank
check or wire  transfer  payable to the order of the Company,  of the  Aggregate
Exercise Price or the proportionate part thereof if exercised in part.

         (b) If this Warrant is exercised in part only, the Company shall,  upon
presentation of this Warrant upon such exercise, execute and deliver (along with
the certificate for the Warrant Shares  purchased) a new Warrant  evidencing the
rights of the  Holder  hereof to  purchase  the  balance of the  Warrant  Shares
purchasable  hereunder  upon the same terms and  conditions as herein set forth.
Upon  proper  exercise  of this  Warrant,  the Company  promptly  shall  deliver
certificates for the Warrant Shares to the Holder duly legended as authorized by
the subscription  form. No fractional  shares or scrip  representing  fractional
shares shall be issued upon exercise of this Warrant;  provided that the Company
shall pay to the holders of the Warrant cash in lieu of such fractional shares.


                                      -1-


<PAGE>

         2. RESERVATION OF WARRANT SHARES; FULLY PAID SHARES; TAXES. The Company
hereby  represents that it has, and until expiration of this Warrant agrees that
it shall,  reserve for issuance or delivery upon exercise of this Warrant,  such
number of shares of the Common Stock as shall be required  for  issuance  and/or
delivery  upon  exercise  of this  Warrant in full,  and agrees that all Warrant
Shares so  issued  and/or  delivered  will be  validly  issued,  fully  paid and
non-assessable,  and  further  agrees to pay all taxes and  charges  that may be
imposed upon such issuance and/or delivery.

         3. PROTECTION AGAINST DILUTION.

         (a) In the event the  Company  shall,  at any time or from time to time
after the date of issuance of this  Warrant,  issue or  distribute to all of the
holders of its shares of Common Stock  evidence of its  indebtedness,  any other
securities of the Company or any cash,  property or other assets (any such event
being herein called a "SPECIAL DIVIDEND"), the Per Share Exercise Price shall be
adjusted  by  multiplying  the Per  Share  Exercise  Price  then in  effect by a
fraction,  the  numerator  of which shall be the then  Current  Market Price (as
defined in paragraph  3(k) below) of the Common Stock,  less the Current  Market
Price of the Special  Dividend  issued or distributed in respect of one share of
Common Stock,  and the denominator of which shall be the Current Market Price of
the Common Stock.  Such adjustment  shall be made  successively  whenever such a
record  date  is  fixed.  Such  adjustment  shall  be  made  whenever  any  such
distribution  is made and shall become  effective  immediately  after the record
date  for  the   determination   of   shareholders   entitled  to  receive  such
distribution.

         (b) In case the Company  shall  hereafter  (i) pay a dividend or make a
distribution on its capital stock in shares of Common Stock,  (ii) subdivide its
outstanding  shares  of Common  Stock  into a greater  number of  shares,  (iii)
combine its  outstanding  shares of Common Stock into a smaller number of shares
or (iv)  issue by  reclassification  of its  Common  Stock any shares of capital
stock of the Company, the Per Share Exercise Price shall be adjusted to be equal
to a fraction,  the numerator of which shall be the Aggregate Exercise Price and
the  denominator of which shall be the number of shares of Common Stock or other
capital stock of the Company  issuable  upon  exercise of this Warrant  assuming
this Warrant had been exercised  immediately prior to such action. An adjustment
made pursuant to this subsection 3(b) shall become effective  immediately  after
the  record  date in the case of a dividend  or  distribution  and shall  become
effective  immediately  after the effective  date in the case of a  subdivision,
combination or reclassification.

         (c)(i) Except as provided in subsections 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share  (determined by dividing (i) the total amount,  if any, received
or  receivable by the Company in  consideration  of the issuance or sale of such
securities plus the consideration,  if any, payable to the Company upon exercise
or conversion  thereof  (collectively,  the "TOTAL  CONSIDERATION")  by (ii) the
number of  additional  shares of Common  Stock  issued,  sold or  issuable  upon
exercise or conversion of such  securities)  which is less than the then Current
Market  Price of the Common  Stock (as defined  below) but not below the current
Per Share Exercise Price (which event is governed by subsection  3(c)(ii)),  the
Per Share  Exercise  Price shall be adjusted as of the date of such  issuance or
sale by  multiplying  the Per Share Exercise Price then in effect by a fraction,
the  numerator  of which  shall be (x) the sum of (A) the  number  of  shares of
Common Stock  outstanding  on the record date of such  issuance or sale plus (B)
the Total Consideration divided by the Current Market Price of the Common Stock,
and the  denominator  of which shall be (y) the number of shares of Common Stock
outstanding  on the record date of such issuance or sale plus the maximum number
of additional  shares of Common Stock issued,  sold or issuable upon exercise or
conversion of such securities.

         (c)(ii) Except as provided in subsection 3(a) and 3(b)(i), in the event
the Company  shall  hereafter  issue or sell any Common  Stock,  any  securities
convertible  into Common  Stock or any  rights,  options or warrants to purchase
Common Stock or securities  convertible  into Common  Stock,  in each case for a
price per share or entitling the holders  thereof to purchase  Common Stock at a
price per share (the  "ISSUE  PRICE"),  (determined  by  dividing  (i) the Total
Consideration  by (ii) the number of additional  


                                       -2-


<PAGE>

shares of Common Stock issuable upon exercise or conversion of such  securities)
which is less than the then  current Per Share  Exercise  Price in effect on the
record date of such issuance,  the Per Share Exercise Price shall be adjusted to
equal the Issue Price.

         (d) In the event of any capital reorganization or reclassification,  or
any  consolidation or merger to which the Company is a party other than a merger
or consolidation in which the Company is the continuing corporation,  or in case
of any sale or conveyance to another entity of the property of the Company as an
entirety  or  substantially  as an  entirety,  or in the  case of any  statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Warrant  shall have the right  thereafter  to receive on the exercise of
this Warrant the kind and amount of securities, cash or other property which the
Holder would have owned or have been entitled to receive  immediately after such
reorganization,  reclassification,  consolidation,  merger,  statutory exchange,
sale or  conveyance  had this Warrant been  exercised  immediately  prior to the
effective date of such reorganization, reclassification,  consolidation, merger,
statutory  exchange,  sale or  conveyance  and in any such case,  if  necessary,
appropriate  adjustment  shall be made in the  application of the provisions set
forth in this Section 3 with respect to the rights and  interests  thereafter of
the  Holder of this  Warrant  to the end that the  provisions  set forth in this
Section 3 shall thereafter  correspondingly be made applicable, as nearly as may
reasonably  be,  in  relation  to any  shares  of stock or other  securities  or
property  thereafter  deliverable  on the  exercise of this  Warrant.  The above
provisions  of  this   subsection  3(e)  shall  similarly  apply  to  successive
reorganizations,    reclassifications,    consolidations,   mergers,   statutory
exchanges,  sales or  conveyances.  The  issuer of any  shares of stock or other
securities or property  thereafter  deliverable  on the exercise of this Warrant
shall be responsible  for all of the  agreements and  obligations of the Company
hereunder. Notice of any such reorganization,  reclassification,  consolidation,
merger,  statutory  exchange,  sale  or  conveyance  and of said  provisions  so
proposed  to be made,  shall be mailed to the Holders of the  Warrants  not less
than 30 days  prior to such  event.  A sale of all or  substantially  all of the
assets of the Company for a  consideration  consisting  primarily of  securities
shall be deemed a consolidation or merger for the foregoing purposes.

         (e) In case any event shall occur as to which the other  provisions  of
this Section 3 are not strictly  applicable  but as to which the failure to make
any adjustment would not fairly protect the purchase rights  represented by this
Warrant in accordance with the essential  intent and principles  hereof then, in
each such case,  the  Holders of Warrants  representing  the right to purchase a
majority of the Warrant Shares subject to all outstanding Warrants may appoint a
firm  of  independent  public   accountants  of  recognized   national  standing
reasonably  acceptable to the Company,  which shall give their opinion as to the
adjustment,  if  any,  on a basis  consistent  with  the  essential  intent  and
principles  established  herein,  necessary  to  preserve  the  purchase  rights
represented  by the  Warrants.  Upon receipt of such  opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants shall be borne by the Company.

         (f) Whenever the Per Share Exercise Price payable upon exercise of each
Warrant is adjusted  pursuant to this  Section 3, the number of shares of Common
Stock underlying a Warrant shall  simultaneously be adjusted to equal the number
obtained by dividing  the  Aggregate  Exercise  Price by the  adjusted Per Share
Exercise Price.

         (g) No  adjustment  in the Per Share  Exercise  Price shall be required
unless such  adjustment  would require an increase or decrease of at least $0.01
per share of Common Stock;  provided,  however,  that any  adjustments  which by
reason of this  subsection  3(g) are not  required  to be made  shall be carried
forward and taken into account in any subsequent  adjustment.  All  calculations
under this Section 3 shall be made to the nearest cent or to the nearest 1/100th
of a share,  as the case may be.  Anything  in this  Section  3 to the  contrary
notwithstanding,  the Company  shall be entitled to make such  reductions in the
Per Share Exercise Price, in addition to those required by this Section 3, as it
in its discretion  shall deem to be advisable in order that any stock  dividend,
subdivision of shares or  distribution of rights to purchase stock or securities
convertible  or  exchangeable  for stock  hereafter  made by the  Company to its
stockholders shall not be taxable.


                                       -3-


<PAGE>

         (h)  Whenever the Per Share  Exercise  Price is adjusted as provided in
this Section 3 and upon any  modification  of the rights of a Holder of Warrants
in accordance  with this Section 3, the Company shall  promptly  obtain,  at its
expense, a certificate of a firm of independent public accountants of recognized
standing  selected by the Board of Directors (who may be the regular auditors of
the  Company)  setting  forth the Per  Share  Exercise  Price and the  number of
Warrant Shares after such adjustment or the effect of such modification, a brief
statement of the facts requiring such adjustment or modification  and the manner
of computing the same and cause copies of such  certificate  to be mailed to the
Holders of the Warrants.

         (i) If the Board of Directors of the Company shall declare any dividend
or other  distribution  with respect to the Common Stock, the Company shall mail
notice thereof to the Holders of the Warrants not less than 30 days prior to the
record date fixed for determining  stockholders  entitled to participate in such
dividend or other distribution.

         (j) If, as a result of an  adjustment  made pursuant to this Section 3,
the Holder of any Warrant  thereafter  surrendered  for  exercise  shall  become
entitled to receive  shares of two or more classes of capital stock or shares of
Common  Stock and other  capital  stock of the  Company,  the Board of Directors
(whose  determination  shall be  conclusive  and shall be described in a written
notice to the  Holder of any  Warrant  promptly  after  such  adjustment)  shall
determine  the  allocation of the adjusted Per Share  Exercise  Price between or
among  shares or such  classes  of capital  stock or shares of Common  Stock and
other capital stock.

         (k) For the purpose of any computation  under Section 3 above, the then
Current  Market Price per share (the "CURRENT  MARKET PRICE") shall be deemed to
be the last sale price of the Common Stock on the trading day prior to such date
or, in case no such  reported  sales take place on such day,  the average of the
last  reported  bid and asked  prices of the Common Stock on such day, in either
case on the principal national  securities exchange on which the Common Stock is
admitted  to trading or listed,  or if not listed or  admitted to trading on any
such  exchange,  the  representative  closing  bid price of the Common  Stock as
reported by the National  Association  of  Securities  Dealers,  Inc.  Automated
Quotations  System  ("NASDAQ"),  or other similar  organization  if NASDAQ is no
longer  reporting such  information,  or, if the Common Stock is not reported on
NASDAQ,   the  high  per  share  bid   price  for  the   Common   Stock  in  the
over-the-counter  market as reported by the National Quotation Bureau or similar
organization,  or if not so available, the fair market value of the Common Stock
as determined by agreement between the Company's Board of Directors,  on the one
part, and the Holders of Warrants  representing the right to purchase a majority
of the Warrant Shares subject to all outstanding  Warrants,  on the second part.
If the Board of Directors  and such Holders fail to agree on the Current  Market
Price  within 60 days of the date of the action  giving  rise to any  adjustment
pursuant to this Section 3, such Holders  shall be entitled to appoint a firm of
independent  public  accountants or appraisers of recognized  national  standing
reasonably acceptable to the Company,  which shall give their opinion as to such
Current  Market  Price on a basis  consistent  with  the  essential  intent  and
principles  established herein.  Upon receipt of such opinion,  the Company will
promptly  mail a copy  thereof to the Holder of this  Warrant and shall make the
adjustments  described therein. The fees and expenses of such independent public
accountants or appraisers shall be borne by the Company.

         4. REGISTRATION UNDER SECURITIES ACT OF 1933. The resale of the Warrant
Shares shall be  registered on the Shelf  Registration  Statement (as defined in
Article 8 of the Note and Warrant Purchase Agreement (the "Purchase  Agreement")
dated as of January 28, 1997, by and among the Company, The Aries Fund, a Cayman
Island Trust, and The Aries Domestic Fund, L.P., a Delaware limited partnership)
and  certain   purchasers  and  the  Holder  of  this  Warrant  shall  have  the
registration rights as provided in Article 8 of the Purchase  Agreement.  If the
Holder is not a party to the Purchase  Agreement,  by acceptance of this Warrant
the  Holder  agrees to  comply  with  provisions  of  Article 8 of the  Purchase
Agreement to the same extent as if it were a party thereto.

         5. LIMITED TRANSFERABILITY.  This Warrant may not be sold, transferred,
assigned or  hypothecated by the Holder except in compliance with the provisions
of the Act and the  applicable  state  securities  "blue  sky"  laws,  and is so
transferable  only  upon the  books of the  Company  which it shall  cause to be
maintained for such purpose. The Company may treat the registered Holder of this
Warrant as he or it appears on the Company's books 


                                       -4-


<PAGE>

at any time as the Holder for all purposes.  The Company shall permit any Holder
of a Warrant  or his duly  authorized  attorney,  upon  written  request  during
ordinary  business  hours,  to inspect and copy or make  extracts from its books
showing  the  registered  holders of  Warrants.  All  Warrants  issued  upon the
transfer  or  assignment  of this  Warrant  will be dated  the same date as this
Warrant, and all rights of the holder thereof shall be identical to those of the
Holder.

         6. LOSS, ETC., OF WARRANT. Upon receipt of evidence satisfactory to the
Company of the loss,  theft,  destruction or mutilation of this Warrant,  and of
indemnity reasonably  satisfactory to the Company, if lost, stolen or destroyed,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall  execute and  deliver to the Holder a new Warrant of like date,  tenor and
denomination.

         7. STATUS OF HOLDER.  This  Warrant does not confer upon the Holder any
right  to vote or to  consent  to or  receive  notice  as a  stockholder  of the
Company, as such, in respect of any matters  whatsoever,  or any other rights or
liabilities as a stockholder, prior to the exercise hereof.

         8. NOTICES.  No notice or other  communication under this Warrant shall
be effective unless,  but any notice or other  communication  shall be effective
and shall be deemed to have been given if, the same is in writing  and is mailed
by first-class mail, postage prepaid, addressed to:

          (a) the  Company  at  3550  General  Atomic  Corporation,  San  Diego,
          California 92121, Attention: Thomas H. Adams, or such other address as
          the Company has designated in writing to the Holder; or

          (b) the Holder at the address  indicated in the notice  provisions  to
          the  Purchase  Agreement,  or other  such  address  as the  Holder has
          designated in writing to the Company.

         9. OPTIONAL  CONVERSION.  Each warrant shall be convertible  into a New
Warrant (as  hereinafter  defined) on a one for one basis.  "New Warrants" shall
mean a new class of warrants  entitling the holders thereof to purchase,  at any
time on or before  the date which is five (5) years  from the date  hereof,  one
share of Common Stock at an exercise price equal to the lesser of (a) $0.15, and
(b) fifty percent (50%) of the average closing bid price of the Common Stock for
either (i) the thirty (30) consecutive  trading days immediately  succeeding the
date of the Required Shareholder Approval, if any (the "Approval Date"), or (ii)
the five (5) consecutive trading days preceding the Approval Date, if any. Other
than the exercise price, the New Warrants shall have the same terms as the Class
A  Warrants.  To the  extent  that  there is no  Required  Shareholder  Approval
necessary the foregoing clause (b) shall be ignored.

         Notwithstanding  the foregoing,  the New Warrants' exercise price shall
be  adjusted at the time of the Final  Closing  Date (as that term is defined in
the Letter between Genta and Paramount  Capital Inc., dated January 28, 1997) if
the exercise price of the Offering  Warrants (as defined below) is less than the
exercise  price of the New  Warrants.  In such event the New  Warrants  exercise
price shall be reduced to equal 50% of the then  current  exercise  price of the
Offering  Warrants (as hereafter  defined).  "Offering  Warrants" shall mean the
warrants  described  in  paragraph  7 of the  Letter  between  the  Company  and
Paramount Capital, Inc. dated January 28, 1997.

         "Required  Shareholder  Approval"  shall  mean  the  authorization  and
approval  by the holders of the Common  Stock of the Company of the  issuance of
the shares of Common Stock underlying the Company's  Senior Secured  Convertible
Bridge Notes, to the extent such authorization is required pursuant to the rules
of the Nasdaq National Market or any other statute, rule or regulation.

         10.  HEADINGS.  The headings of this  Warrant  have been  inserted as a
matter of convenience and shall not affect the construction hereof.

         11.  APPLICABLE LAW. This Warrant shall be governed by and construed in
accordance  with the law of the  State  of New York  without  giving  effect  to
principles of conflicts of law thereof.


                                       -5-


<PAGE>

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its Chief  Executive  Officer and its corporate seal to be hereunto  affixed and
attested by its Secretary this January 28, 1997


                                       GENTA INCORPORATED



                                       By: /s/Thomas H. Adams
                                           ----------------------
                                              Name: Thomas H. Adams
                                              Title:    Chairman


ATTEST:



- --------------------
    Secretary



[Corporate Seal]


                                       -6-


<PAGE>

                                  SUBSCRIPTION

         The   undersigned,   ____________________________,   pursuant   to  the
provisions  of the  foregoing  Warrant,  hereby  elects to  exercise  the within
Warrant to the extent of purchasing _____________________ shares of Common Stock
thereunder and hereby makes payment of $_______________ by certified or official
bank check in payment of the exercise price therefor.

Dated:_______________                    Signature:_____________________________

                                         Address:_______________________________


                                   ASSIGNMENT

         FOR  VALUE  RECEIVED   _______________________________________   hereby
sells,  assigns and  transfers  unto  _____________________________________  the
foregoing  Warrant  and all  rights  evidenced  thereby,  and  does  irrevocably
constitute and appoint _____________________________, attorney, to transfer said
Warrant on the books of Genta, Inc.


Dated:_______________                    Signature:_____________________________

                                         Address:______________________________


                               PARTIAL ASSIGNMENT

         FOR  VALUE  RECEIVED   __________________________  hereby  assigns  and
transfers unto _________________________ the right to purchase __________ shares
of the Common  Stock,  no par value per  share,  of Genta,  Inc.  covered by the
foregoing  Warrant,  and a  proportionate  part of said  Warrant  and the rights
evidenced    thereby,    and   does    irrevocably    constitute   and   appoint
__________________________,  attorney,  to transfer that part of said Warrant on
the books of Genta, Inc.


Dated:_______________                    Signature:___________________________

                                         Address:_____________________________


                                       -7-



                                                                    EXHIBIT 10.9

         SECURITY  AGREEMENT,  dated  as of  January  28,  1997,  between  GENTA
INCORPORATED,  a Delaware  corporation  (the  "Company"  or  "Debtor"),  with an
address at 3550 General  Atomics  Court,  Building 9, 2nd floor,  San Diego,  CA
92121 and PARAMOUNT CAPITAL, INC., a New York corporation with an address at 787
Seventh Avenue, New York, New York 10019 (the "Secured Party"),  solely as agent
for the holders (the  "Holders") of the  Company's  Senior  Secured  Convertible
Bridge Notes (the "Notes") and not in its individual capacity.

         WHEREAS: The Holders have each extended credit or will extend credit to
the Company represented by separate Notes in an aggregate principal amount of up
to $3,000,000.

         The Holders  have  entered  into Note and Warrant  Purchase  Agreements
pursuant to which,  among other things,  the Secured Party has been appointed to
act as agent under this  Agreement  for the benefit of all Holders to secure the
obligations of the Debtor to the Holders under their respective Notes.

         In  consideration  of the  extension of credit to the Company under the
Notes, the Debtor wishes to grant a security  interest in certain  collateral to
the Secured Party for the benefit of all Holders.

         NOW, THEREFORE,  the parties hereto,  intending legally to be bound, do
hereby  agree as  follows  (terms  used and not  defined  herein  shall have the
meanings as defined in the Uniform  Commercial Code as in effect in the State of
California (the "UCC")):

         1. Grant of a Security  Interest.  Debtor  hereby grants to the Secured
Party a security interest in the Collateral (as defined in Section 2).

         2. Collateral. The collateral covered by this Agreement consists of all
property  of the  following  types,  wherever  located  and whether now owned or
hereafter owned or acquired by Debtor,  whether or not affixed to realty, in all
Proceeds  and  Products  thereof  in  any  form,  in  all  parts,   accessories,
attachments,   special  tools,   additions,   replacements,   substitutions  and
accessions  thereto  or  therefor,  and in all  increases  or  profits  received
therefrom, including, without limitation, all property described in any schedule
from time to time delivered by Debtor to the Secured Party: Equipment, Fixtures,
Inventory, Investment Property, Rights to Proceeds to Written Letters of Credit,
Accounts,   Chattel  Paper,   Documents,   Patents,   Patents  Pending,   Patent
Applications (and other similar rights whether  perfected or not),  Instruments,
Goods, Money and General  Intangibles  (except the real property leases to which
the  Debtor  is,  or will be, a party)  (all of the  foregoing,  including  such
proceeds,  being collectively referred to as the "Collateral").  Notwithstanding
the foregoing,


<PAGE>

the Collateral shall not include the Company's equity interest in its Genta-Jago
Joint Venture and JBL Scientific, Inc.

         3. Debtor's  Obligations  Secured  Hereby.  Debtor's  obligations  (the
"Obligations")  to the  Secured  Party  secured  hereby  for the  benefit of the
Holders are the  payment of the  principal  sum and  interest  evidenced  by the
Notes,  and  performance  and  discharge of each and every  obligation of Debtor
under this Agreement and the Notes.

         4. Debtor's  Representations  and  Warranties.  Debtor  represents  and
warrants and, so long as this Security  Agreement is in effect,  shall be deemed
continuously to represent and warrant, that:

         (a) Debtor owns the Collateral  free and clear of any Liens (as defined
in the Note), except for Liens permitted by Section 6(b) of the Note.

         (b) Debtor has all  necessary  corporate  power and  authority  and has
taken all  corporate  action  necessary  to execute,  deliver  and perform  this
Agreement  and the Notes and to  encumber  and grant a security  interest in the
Collateral.

         (c)  There is no  effective  financing  statement  or other  instrument
similar  in effect  covering  all or any part of the  Collateral  on file in any
recording  office  except  as (i) may have  been  filed in favor of the  Secured
Party,  (ii) as may have been filed by any landlords of real property  leased by
the Debtor, or (iii) as set forth on Schedule I hereto.

         (d) This  Agreement  creates a valid  security  interest of the Secured
Party in the Collateral securing payment of the Obligations.  Upon the filing of
the  financing  statements  and the other  instruments  similar in effect  under
Section 5(b) or the taking of any other action necessary to perfect, the Secured
Party  will have  valid  and  perfected  first  priority  liens on and  security
interests in the Collateral  (except that such liens and security  interests may
not be first priority to the extent  preceded by any Liens  permitted by Section
6(b) of the Note existing prior to the date hereof).

         (e) No  consent,  authorization,  approval  or other  action by, and no
notice to or filing with, any governmental  authority,  regulatory body, lessor,
franchise  or other  person or entity is required for the grant by Debtor of the
security  interest granted hereby or for the execution,  delivery or performance
of this  Agreement  by Debtor or for the  perfection  or exercise by the Secured
Party  of its  rights  and  remedies  hereunder,  except  filings  of  financing
documents or as otherwise set forth on Schedule I hereto.

         (f)  Debtor  does not  transact  any  part of its  business  under  any
tradenames, division names, assumed names or other names, except for their names
set forth in the preamble or on Schedule I hereto;  Debtor's business  addresses
and  chief  executive  offices  are as set  forth in the  preamble  hereto;  and
Debtor's records concerning the Collateral are kept at such address.


                                     - 2 -


<PAGE>

         (g) Each Account,  General  Intangible  and Chattel Paper  constituting
Collateral is genuine and  enforceable in accordance  with its terms against the
party obligated to pay it (the "Account Debtor"),  and no Account Debtor has any
defense,  setoff,  claim or  counterclaim  against  Debtor which can be asserted
against the Secured  Party,  whether in any proceeding to enforce the Collateral
or otherwise.

         (h) Debtor will promptly deliver to the Secured Party a schedule of all
Accounts,  General  Intangibles  and Chattel  Paper,  and will  provide  updated
schedules thereof from time to time as the Secured Party may reasonably request,
but not more frequently than monthly.  The amounts represented on such schedules
by Debtor to the Secured Party as owing by each Account Debtor or by all Account
Debtors are and will be the correct amounts actually and  unconditionally  owing
by such Account  Debtor or Account  Debtors  individually  and in the aggregate,
except for normal cash discounts where applicable.

         (i)  Each  Instrument  and each  Document  constituting  Collateral  is
genuine and in all respects what it purports to be.

         (j) Any  Collateral  which is a Fixture is affixed to real  property at
Debtor's addresses specified on Schedule II hereto.

         5. Debtor's  Covenants.  Debtor  agrees and  covenants for itself,  its
successors and assigns that:

         (a) The Collateral will be used solely for business  purposes of Debtor
and will  remain in the  possession  or under  the  control  of Debtor  (sale or
replacement  in the  ordinary  course  excepted)  and  will  not be used for any
unlawful purpose. The Collateral will not be misused,  abused, wasted or allowed
to  deteriorate  (ordinary  wear  and  tear  excepted).  Debtor  will  keep  the
Collateral,  as  appropriate  and  applicable,  in  good  condition  and  repair
(ordinary wear and tear excepted),  and will clean,  shelter, and otherwise deal
with the Collateral in all such ways as are  considered  good practice by owners
of like property.

         (b) Debtor has executed  and will  promptly  file with the  appropriate
governmental  authorities,  or deliver to the Secured  Party for  filing,  UCC-1
Financing Statements with respect to the Collateral. Debtor shall, at no cost to
the Secured  Party,  promptly  execute,  acknowledge  and deliver all such other
documents as the Secured Party reasonably deems necessary to create, perfect and
continue the security  interest in the Collateral  contemplated  hereby.  Debtor
will  pay all  costs of title  searches  and  filing  of  financing  statements,
assignments  and other documents in all public offices  reasonably  requested by
the  Secured  Party,  and will not,  without  the prior  written  consent of the
Secured Party,  file or authorize or permit to be filed in any public office any
financing statement naming Debtor as debtor and not naming the Secured Party, as
agent for the Holders,  as secured  party,  except with respect to other secured
indebtedness permitted by the terms of the Notes.

         (c) Debtor will defend the Collateral against the claims and demands of
all other parties, including, without


                                      - 3 -


<PAGE>

limitation,  defenses, setoffs, claims and counterclaims asserted by any Account
Debtor against Debtor or the Secured Party, except, as to Inventory,  purchasers
and  lessees  in the  ordinary  course  of  Debtor's  business;  will  keep  the
Collateral free from all security  interests or other  encumbrances,  except the
Security Interest and except as permitted by Section 6(b) of the Notes; and will
not  sell,  transfer,  lease,  assign,  deliver  or  otherwise  dispose  of  any
Collateral  or any interest  therein  without the prior  written  consent of the
Secured  Party,  except that Debtor may sell or lease  Inventory in the ordinary
course of Debtor's business and sell, lease or replace equipment in the ordinary
course of business.

         (d) Debtor will, at the Secured Party's request, mark any and all books
and records to indicate the Security Interest.

         (e)  Debtor  will  deliver  to the  Secured  Party,  upon  demand,  all
Documents and all Chattel Paper (duly endorsed to Secured  Party)  constituting,
representing  or  relating  to the  Collateral  or any  part  thereof,  and  any
schedules,  invoices,  shipping documents,  delivery receipts,  purchase orders,
contracts or other  documents  representing or relating to the Collateral or any
part thereof.

         (f) Debtor  will notify the  Secured  Party  promptly in writing of any
change in Debtor's business addresses or chief executive offices,  any change in
the address at which records  concerning  the Collateral are kept and any change
in Debtor's name, identity or corporate or other structure.

         (g) Debtor will prevent the  Collateral  or any part thereof from being
or becoming an accession to other goods not covered by this Security Agreement.

         (h) Debtor shall pay all out-of-pocket  expenses,  including reasonable
attorneys' fees and costs,  reasonably incurred by the Secured Party after or in
reasonable  anticipation  of  the  occurrence  of an  Event  of  Default  in the
preservation, realization, enforcement or exercise of any of the Secured Party's
rights under this Agreement.

         (i) Any and all  Collateral  described  or referred to in the  granting
clauses  hereof  which is  hereafter  acquired  shall,  and  without any further
conveyance, assignment or act on the part of Debtor or the Secured Party, become
and be subject to the security  interests herein granted as fully and completely
as though specifically  described herein, but nothing in this Section 5(i) shall
be deemed to modify or change  the  obligations  of Debtor  under  Section  5(b)
hereof.

         (j) Upon request of the Secured Party, forthwith execute and deliver or
cause to be executed and delivered to the Secured Party,  in due form for filing
or  recording  (and pay the cost of filing or  recording  the same in all public
offices  deemed  necessary by the Secured  Party),  such  assignments,  security
agreements, pledge agreements, consents, waivers, financing statements, stock or
bond powers, and other documents,  and do such other acts and things, all as the
Secured Party may from time to


                                      - 4 -


<PAGE>

time request, to establish and maintain to the satisfaction of the Secured Party
valid perfected Liens in all Collateral  (free of all other Liens,  claims,  and
rights of third  parties  whatsoever,  except  for  Liens,  claims,  and  rights
permitted by this Security Agreement or as set forth on the Schedules hereto).

         6. Certain Provisions Concerning Collateral.

         (a) After the occurrence of an Event of Default (as defined below), the
Secured  Party may notify all or any Account  Debtors of the  security  interest
created hereby and may also direct such Account  Debtors to make all payments on
Collateral to the Secured Party. All payments on and from Collateral received by
the Secured Party directly or from Debtor shall be applied to the Obligations in
accordance  with  Section 9. The Secured  Party may demand of Debtor in writing,
before or after  notification  to Account  Debtors  and  without  waiving in any
manner the security  interest created hereby,  that any payments on and from the
Collateral  received  by  Debtor:  (i)  shall be held by Debtor in trust for the
Secured Party in the same medium in which received; (ii) shall not be commingled
with any assets of Debtor;  and (iii) shall be delivered to Secured Party in the
form received,  properly endorsed to permit collection,  not later than the next
business day  following the day of their  receipt;  and Debtor shall comply with
such demand.  Debtor shall also promptly  notify the Secured Party of the return
to or  repossession  by Debtor of Goods  underlying any  Collateral,  other than
returns or repossession in the ordinary course of Debtor's  business,  and shall
hold the same in trust for the  Secured  Party and shall  dispose of the same as
Secured Party directs.

         (b) If any  Collateral  consists of investment  securities,  other than
instruments  purchased  with the  proceeds  of the  Offering  (as defined in the
Note),  Debtor has delivered and will continue to deliver such securities to the
Secured  Party  to be held  as  Collateral  and,  after  an  Event  of  Default,
authorizes  the Secured  Party to transfer the same or any part thereof into its
own name or that of its  nominee so that the  Secured  Party or its  nominee may
appear of record as the sole owner  thereof.  Upon demand,  Debtor shall deliver
promptly  to the  Secured  Party  copies  of all  notices,  statements  or other
communications received by them or their nominees as owner of such securities.

         (c) Until the  occurrence of an Event of Default,  Debtor  reserves the
right to  receive  all  income  from or  interest  on the  Collateral.  Upon the
occurrence of an Event of Default,  Debtor will not demand or receive any income
from or interest on such  Collateral  and, if Debtor receives any such income or
interest without any demand by it, the same shall be held by Debtor in trust for
the Secured Party in the same medium in which received,  shall not be commingled
with any assets of Debtor and shall be  delivered  to the  Secured  Party in the
form received,  properly endorsed to permit collection,  not later than the next
business day following  the day of its receipt.  The Secured Party may apply the
net cash  receipts  from such income or interest to payment of the  Obligations,
provided  that the Secured  Party  shall  account for and pay over to Debtor any
such income or interest remaining after payment in full of the Obligations.


                                     - 5 -


<PAGE>

         (d) Whether or not an Event of Default has occurred,  Debtor authorizes
the Secured  Party to (i) receive any  increase in or profits on the  Collateral
(other  than  Inventory,  in the case  where no Event of Default  has  occurred)
(including,  without limitation, any stock issued as a result of any stock split
or dividend,  any capital  distributions  and the like), and to hold the same as
part  of the  Collateral,  (ii)  receive  any  payment  or  distribution  on the
Collateral  upon  redemption by, or dissolution  and  liquidation of, the issuer
thereof,  (iii)  surrender  such  Collateral  or any part  thereof  in  exchange
therefor,  and (iv)  hold  the net  cash  receipts  from  any  such  payment  or
distribution  described  in clause  (ii)  hereof as part of the  Collateral.  If
Debtor receives any such increase,  profits,  payments or distributions,  Debtor
will  receive and deliver same  promptly to the Secured  Party on the same terms
and conditions set forth in Section 6(b) hereof  respecting  income or interest,
to be held by the Secured Party as part of the Collateral.

         7. Events of Default.  The  occurrence of any "Events of Default" under
the Notes shall constitute an "Event of Default" under this Security Agreement.

         8. Remedies on Default.  (a) Upon the occurrence of an Event of Default
the Secured Party may, by notice to Debtor,  (or automatically in the case of an
Event of  Default  pursuant  to  Section  7 of the Note not  requiring  notice),
declare the aggregate unpaid principal  balance of all the Notes,  together with
all unpaid  accrued  interest  thereon,  to be  immediately  due and payable and
thereupon  all such amounts shall be and become  immediately  due and payable to
the Secured Party for the benefit of the Holders.  Upon such  acceleration,  the
Secured  Party,  for  the  benefit  of  the  Holders,  shall  have  all  rights,
privileges,  powers and remedies  provided a secured party under the UCC and any
other  applicable  law. Upon the existence or occurrence of an Event of Default,
the Secured  Party may require  Debtor to assemble  the  Collateral  and make it
available to the Secured  Party at a place or places  designated  by the Secured
Party, and the Secured Party may use and operate the Collateral.

         (b) Without in any way  requiring  notice to be given in the  following
time and manner,  Debtor  agrees  that any notice by the Secured  Party of sale,
disposition  or other  intended  action  hereunder  or in  connection  herewith,
whether required by the UCC or otherwise,  shall constitute reasonable notice to
Debtor if such notice is mailed by regular or certified mail postage prepaid, at
least seven business days prior to such action,  to Debtor's  address  specified
above or to any other  address  which  Debtor  has  specified  in writing to the
Secured  Party as the  address  to  which  notices  hereunder  shall be given to
Debtor.

         (c) After an Event of Default,  the Secured  Party may demand,  collect
and  sue  on any  of  the  Accounts,  Chattel  Paper,  Instruments  and  General
Intangibles  (in either  Debtor's or the Secured  Party's  name at the  latter's
option);  may enforce,  compromise,  settle or discharge such Collateral without
discharging the Obligations or any part thereof;  and may indorse  Debtor's name
on any and all checks, commercial paper, and any other Instruments pertaining to
or constituting Collateral.


                                      - 6 -


<PAGE>

         9.  Payments  After an Event of  Default.  All  payments  received  and
amounts  realized by the Secured Party pursuant to Section 8, including all such
payments and amounts  received  after the entire  unpaid  principal and interest
amount of the Notes has been  declared due and payable,  as well as all payments
or amounts then held or thereafter  received by the Secured Party as part of the
Collateral  while an Event of Default  shall be  continuing,  shall be  promptly
applied and distributed by the Secured Party in the following order of priority:

         (a)  first,  to  the  payment  of all  costs  and  expenses,  including
reasonable legal expenses and attorneys' fees, incurred or made hereunder by the
Secured Party,  and/or by any other Holder or Holders,  including any such costs
and expenses of  foreclosure or suit, if any, and of any sale or the exercise of
any  other  remedy  under  Section  8, and of all  taxes,  assessments  or liens
superior to the lien granted  under this Security  Agreement,  except any taxes,
assessments  or other superior lien subject to which any said sale under Section
8 hereof may have been made; and

         (b)  second,  to the payment to each Holder of the amount then owing or
unpaid on such  Holder's  Note,  and in case the  payments  received and amounts
realized by the Secured  Party  shall be  insufficient  to pay in full the whole
amount  so due,  owing  or  unpaid  upon all the  Notes,  then  ratably,  in the
proportion that the unpaid  principal amount of each Note bears to the aggregate
unpaid  principal  amount of all Notes, and in the proportion that the amount of
interest  accrued  under each Note  bears to the  aggregate  amount of  interest
accrued under all the Notes,  with  application on each Note to be made first to
the unpaid interest thereon,  and second, to the unpaid principal thereof,  such
application to be made upon  presentation of the Notes and the notation  thereon
of the payment, if partially paid, or the surrender and cancellation thereof, if
fully paid; and

         (c) third, to the payment of the balance or surplus, if any, to Debtor,
its successors and assigns, or to whomsoever may be lawfully entitled to receive
the same.

         10. Power of Attorney.  Debtor  hereby  appoints the Secured  Party the
attorney-in-fact  of Debtor to prepare,  sign and file or record,  for Debtor in
Debtor's name, any financing  statement and to take any other action  reasonably
deemed by the Secured  Party  necessary or desirable to perfect and continue the
perfection  of the  security  interest of the Secured  Party  hereunder,  and to
perform any obligations of Debtor hereunder,  at Debtor's  expense,  but without
obligation  to do so. Such power of attorney is coupled  with an interest and is
irrevocable so long as this Agreement is in effect.

         11. Secured Party's Right to Cure;  Reimbursement.  In the event Debtor
should fail to do any act as herein provided, the Secured Party may, but without
obligation to do so, with notice to Debtor,  and without  releasing  Debtor from
any obligation hereof,  make or do the same in such manner and to such extent as
the  Secured  Party may deem  necessary  to protect the  Collateral,  including,
without  limitation,  the  defense  of  any  action  purporting  to  affect  the
Collateral or the rights or powers of the Secured


                                      - 7 -


<PAGE>

Party hereunder,  at Debtor's expense.  Debtor shall reimburse the Secured Party
for expenses reasonably incurred under this Section 11.

         12. Miscellaneous.  (a) This Agreement, together with the covenants and
warranties contained in it, shall inure to the benefit of the Secured Party, the
Holders  and  their   respective   successors,   assigns,   heirs  and  personal
representatives, and shall be binding upon Debtor, its successors and assigns.

         (b) Any notice or other communication required or permitted to be given
hereunder  shall be in writing  and shall be mailed by  certified  mail,  return
receipt  requested,  or by Federal  Express,  Express Mail or similar  overnight
delivery or courier service or delivered against receipt to the party to whom it
is to be given (i) if to Debtor,  at its  address  set forth in the  preamble to
this  Agreement  to the  attention  of its  President  or (ii) if to the Secured
Party,  at its  address  set forth in the  preamble  of this  Agreement,  to the
attention of its Chairman.  Any notice or other communication given by certified
mail shall be deemed given at the time of  certification  thereof,  except for a
notice  changing a party's  address  which shall be deemed  given at the time of
receipt thereof. Any notice given by other means permitted by this Section 12(b)
shall be deemed given at the time of receipt thereof.

         (c) This Agreement shall  terminate on the  satisfaction in full of all
of the Obligations and, on such termination,  the Secured Party shall release to
Debtor the security interest granted in the Collateral hereunder; provided, that
if,  after  receipt of any  payment of all or any part of the  Obligations,  the
Secured  Party is for any reason  compelled  to  surrender  such  payment to any
person or entity, because such payment is determined to be void or voidable as a
preference,  impermissible  setoff,  or a diversion of trust  funds,  or for any
other reason,  this Agreement shall continue in full force  notwithstanding  any
contrary  action which may have been taken by the Secured Party in reliance upon
such payment,  and any such contrary action so taken shall be without  prejudice
to the Secured  Party's  rights under this Agreement and shall be deemed to have
been conditioned upon such payment having become final and irrevocable.

         (d)  If any  provision  of  this  Agreement  is  invalid,  illegal,  or
unenforceable,  the balance of this Agreement shall remain in effect, and if any
provision is inapplicable to any person or circumstance,  it shall  nevertheless
remain applicable to all other persons and circumstances.

         (e) The  headings  in this  Agreement  are  solely for  convenience  of
reference and shall be given no effect in the construction or  interpretation of
this Agreement.

         (f) This Agreement may be executed in any number of counterparts,  each
of which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

         (g) This  Agreement  shall be governed by and  construed in  accordance
with the laws of the State of Delaware.


                                      - 8 -


<PAGE>

         (h) No course of dealing  and no delay or  omission  on the part of the
Secured  Party in  exercising  any right or  remedy  shall  operate  as a waiver
thereof or otherwise  prejudice the Secured Party's rights,  powers or remedies.
No right,  power or remedy  conferred by this  Agreement  upon the Secured Party
shall be exclusive of any other right, power or remedy referred to herein or now
or hereafter available at law, in equity, by statute or otherwise,  and all such
remedies may be exercised singly or concurrently.

         (i) This Agreement sets forth the entire  understanding  of the parties
with respect to the subject  matter hereof,  supersedes all existing  agreements
among them concerning such subject matter, and may be modified only by a written
instrument duly executed by each party.

         (j) Debtor  irrevocably  consents to the  jurisdiction of the courts of
the  State  of New  York  and of any  federal  court  located  in such  State in
connection  with any action or  proceeding  arising  out of or  relating to this
Agreement,  any document or instrument delivered pursuant to, in connection with
or simultaneously with this Agreement, or a breach of this Agreement or any such
document or instrument. In any such action or proceeding, Debtor waives personal
service of any  summons,  complaint  or other  process and agrees  that  service
thereof may be made in accordance with Section 12(b).  Within 30 days after such
service,  or such other time as may be  mutually  agreed  upon in writing by the
attorneys for the parties to such action or  proceeding,  Debtor shall appear or
answer such summons, complaint, or other process.

         (k) This Agreement may be amended, or any of its provisions waived only
by a written instrument executed by the Company and the Secured Party.

         IN WITNESS WHEREOF,  the parties have executed this Security  Agreement
on the date set forth above.

                                       GENTA INCORPORATED


                                       By: /s/Thomas H. Adams
                                           ----------------------
                                             Name:   Dr. Thomas H. Adams
                                             Title:  President and
                                                     Chief Executive Officer

                                       PARAMOUNT CAPITAL, INC.


                                       By: /s/Lindsay A. Rosenwald
                                           ---------------------------
                                             Name:   Lindsay A. Rosenwald, M.D
                                             Title:  President


                                      - 9 -






                                                                   EXHIBIT 10.10


                                                                JANUARY 28, 1997

VIA FACSIMILE
(619) 455-2712

GENTA INCORPORATED
3550 GENERAL ATOMICS COURT
SAN DIEGO, CA 92121

DEAR SIRS:

         REFERENCE  IS MADE TO OUR  RECENT  DISCUSSIONS  RELATING  TO A PROPOSED
OFFERING OF UNITS (THE "UNITS")  CONSISTING OF SENIOR SECURED CONVERTIBLE NOTES,
SERIES D PREFERRED  STOCK AND WARRANTS TO BE ISSUED BY GENTA  INCORPORATED  (THE
"COMPANY")  AS  HEREINAFTER  DESCRIBED.  BASED UPON OUR  DISCUSSIONS,  FINANCIAL
MATERIALS WHICH YOU HAVE SUBMITTED TO US AND REPRESENTATIONS WHICH YOU HAVE MADE
TO US  DESCRIBING  THE COMPANY  AND ITS  PRINCIPALS,  THE  PRESENT AND  PROPOSED
BUSINESS  ACTIVITIES OF THE COMPANY AND THE COMPANY'S  OPERATIONS  AND FINANCIAL
CONDITION,  WE HEREBY  CONFIRM OUR  INTEREST IN ACTING AS  PLACEMENT  AGENT (THE
"PLACEMENT  AGENT"),  ON A "BEST EFFORTS" BASIS, OF A PRIVATE PLACEMENT OFFERING
OF THE COMPANY'S  UNITS (THE  "OFFERING"),  UPON THE  FOLLOWING  BASIC TERMS AND
CONDITIONS:

         1. THE  PLACEMENT  AGENT WILL  INTRODUCE  THE  COMPANY  TO  "ACCREDITED
INVESTORS" AS DEFINED IN REGULATION D PROMULGATED  UNDER THE  SECURITIES  ACT OF
1933, AS AMENDED (THE "ACT") FOR THE PURCHASE OF UNITS AND THE COMPANY WILL SELL
DIRECTLY TO SUCH PURCHASERS A MINIMUM OF 25 UNITS (THE "MINIMUM OFFERING") AND A
MAXIMUM OF 75 UNITS  (THE  "MAXIMUM  OFFERING"),  WITH AN OPTION IN FAVOR OF THE
PLACEMENT AGENT TO OFFER UP TO AN ADDITIONAL 50 UNITS TO COVER  OVER-ALLOTMENTS.
EACH  UNIT WILL  CONSIST  OF (A)  $70,000  PRINCIPAL  AMOUNT  OF SENIOR  SECURED
CONVERTIBLE  NOTES (THE "NOTES"),  (B) 3000 SHARES OF SERIES D PREFERRED  STOCK,
STATED VALUE $10.00 PER SHARE,  OF THE COMPANY  (ALSO  REFERRED TO HEREIN AS THE
"PREFERRED  STOCK")  AND (C)  333,334  WARRANTS  (THE  "WARRANTS").  SUBJECT  TO
RESTRICTIONS ON TRANSFERABILITY UNDER APPLICABLE SECURITIES LAWS, THE COMPONENTS
OF THE UNITS WILL BE IMMEDIATELY  SEPARABLE.  THE RIGHTS AND  PREFERENCES OF THE
PREFERRED  STOCK  ARE  SUBSTANTIALLY  AS SET FORTH IN  EXHIBIT  A HERETO.  FOR A
DESCRIPTION OF THE NOTES PLEASE REFER TO EXHIBIT B.

         2. SUBJECT TO MARKET AND OTHER  CONDITIONS  AT THE TIME OF THE OFFERING
CONTEMPLATED  HEREIN,  THE  UNITS  WILL BE  OFFERED  AT  $100,000  PER UNIT (THE
"INITIAL OFFERING PRICE").

         3. AN  ESCROW  AGENT  REASONABLY  ACCEPTABLE  TO THE  COMPANY  SHALL BE
DESIGNATED  BY THE  PLACEMENT  AGENT TO HOLD  SUBSCRIPTIONS  FOR THE  BENEFIT OF
CUSTOMERS  PENDING THE CLOSING OF THE  OFFERING.  THE FINAL  CLOSING DATE OF THE
OFFERING  WILL OCCUR NO LATER THAN  SIXTY  (60) DAYS  FOLLOWING  THE DATE OF THE
OFFERING  MEMORANDUM (THE  "MEMORANDUM"),  SUBJECT TO EXTENSION AT THE OPTION OF
THE  PLACEMENT  AGENT FOR AN  ADDITIONAL  SIXTY  (60) DAYS (THE  "FINAL  CLOSING
DATE").  IN THE EVENT  THAT  VALID  SUBSCRIPTIONS  FOR AT LEAST 25 UNITS ARE NOT
RECEIVED BY THE FINAL CLOSING DATE,  SUBSCRIPTIONS  WILL BE RELEASED FROM ESCROW
AND RETURNED TO CUSTOMERS,  WITH INTEREST.  UPON RECEIPT OF THE MINIMUM OFFERING
AMOUNT,  THE PLACEMENT AGENT MAY HOLD A CLOSING (THE "INITIAL  CLOSING") AND MAY
HOLD SUBSEQUENT  CLOSINGS ON AN INTERIM BASIS UNTIL THE MAXIMUM  OFFERING AMOUNT
(INCLUDING  ANY  OVER-ALLOTMENT  AMOUNT)  HAS BEEN  REACHED  OR UNTIL  THE FINAL
CLOSING DATE, WHICHEVER IS EARLIER.

         4. PENDING COMPLETION OR TERMINATION (PURSUANT TO PARAGRAPH 9 BELOW) OF
THE OFFERING,  THE COMPANY  AGREES THAT IT WILL NOT (A) NEGOTIATE WITH ANY OTHER
PERSON OR ENTITY RELATING TO A POSSIBLE PUBLIC OR PRIVATE  OFFERING OR PLACEMENT
OF ITS  SECURITIES  OR (B)  DISPOSE  OF ANY  ASSETS OF THE  COMPANY  (INCLUDING,
WITHOUT  LIMITATION,  CREATING OR PERMITTING  THE IMPOSITION OF ANY LIENS) OTHER
THAN IN THE ORDINARY COURSE OF BUSINESS.


                               


<PAGE>

         5. THE COMPANY WILL, AS SOON AS PRACTICABLE, BUT NOT LATER THAN 30 DAYS
AFTER THE FINAL CLOSING DATE OR A QUALIFIED  OFFERING (AS DEFINED IN EXHIBIT B),
(A) FILE A SHELF  REGISTRATION  STATEMENT (THE "SHELF  REGISTRATION  STATEMENT")
WITH  RESPECT  TO (I) THE  RESALE OF THE SHARES OF COMMON  STOCK  ISSUABLE  UPON
CONVERSION OF THE PREFERRED STOCK  (INCLUDING THE PREFERRED STOCK UNDERLYING THE
NOTES AND THE BRIDGE  NOTES),  (II) THE  WARRANTS AND (III) THE SHARES OF COMMON
STOCK ISSUABLE UPON EXERCISE OF THE WARRANTS  (INCLUDING THE BRIDGE  WARRANTS OR
THE NEW WARRANTS (AS DEFINED IN EXHIBIT B), AS THE CASE MAY BE)  (TOGETHER,  THE
"REGISTRABLE  CAPITAL STOCK") WITH THE SEC AND USE ITS BEST EFFORTS TO HAVE SUCH
SHELF  REGISTRATION  STATEMENT  DECLARED  EFFECTIVE BY THE SEC PRIOR TO THE DATE
WHICH IS 75 DAYS AFTER THE FINAL  CLOSING DATE (SUBJECT TO PENALTIES FOR FAILURE
TO EFFECT  SUCH  REGISTRATION  IN THE TIME FRAMES  REQUIRED)  AND (B) CAUSE SUCH
SHELF REGISTRATION  STATEMENT TO REMAIN EFFECTIVE UNTIL SUCH DATE AS THE HOLDERS
OF THE  SECURITIES  HAVE  COMPLETED  THE  DISTRIBUTION  DESCRIBED  IN THE  SHELF
REGISTRATION STATEMENT OR AT SUCH TIME THAT SUCH SHARES ARE NO LONGER, BY REASON
OF RULE 144(K) UNDER THE SECURITIES ACT,  REQUIRED TO BE REGISTERED FOR THE SALE
THEREOF BY SUCH HOLDERS.  IF REQUESTED BY THE PLACEMENT AGENT, AND IN ACCORDANCE
WITH APPLICABLE  SECURITIES LAWS, THE SHELF  REGISTRATION  STATEMENT SHALL COVER
THE  DIRECT  SALE OF SUCH  REGISTRABLE  CAPITAL  STOCK  TO THE  HOLDERS  OF SUCH
SECURITIES.  THE  REGISTRABLE  CAPITAL  STOCK  WILL BE  SUBJECT  TO A  STAGGERED
"LOCK-UP" AS MAY BE DEEMED ADVISABLE BY THE PLACEMENT AGENT.

         6. THE PLACEMENT AGENT WILL RECEIVE CASH COMMISSIONS EQUAL TO 9% OF THE
PRICE  OF THE  UNITS  ISSUED  IN THE  OFFERING  (THE  "CASH  COMMISSIONS").  THE
PLACEMENT AGENT MAY, IN ITS DISCRETION, RETAIN OTHER PLACEMENT AGENTS, WHO SHALL
BE MEMBERS IN GOOD STANDING OF THE NATIONAL  ASSOCIATION OF SECURITIES  DEALERS,
INC.  ("NASD"),  TO ACT AS  SELECTED  DEALERS IN PLACING  THE UNITS.  SUCH OTHER
PLACEMENT  AGENTS  WILL  BE  COMPENSATED  BY  THE  PLACEMENT  AGENT  OUT  OF ITS
COMMISSIONS.  THE  COMPANY HAS  ADVISED  THE  PLACEMENT  AGENT THAT NO PERSON IS
ENTITLED,  DIRECTLY OR INDIRECTLY, TO COMPENSATION FROM THE COMPANY FOR SERVICES
AS A FINDER IN CONNECTION  WITH THE PROPOSED  OFFERING OR ANY OTHER  TRANSACTION
CONTEMPLATED BY THIS LETTER OF INTENT.

         7. EACH WARRANT  ENTITLES THE HOLDER  THEREOF TO PURCHASE,  AT ANY TIME
OVER A FIVE YEAR PERIOD ONE SHARE OF COMMON STOCK AT AN EXERCISE  PRICE EQUAL TO
THE LESSER OF (A) $.30 PER SHARE AND (B) 50% OF THE AVERAGE CLOSING BID PRICE OF
THE COMMON STOCK FOR EITHER (I) THE THIRTY CONSECUTIVE  TRADING DAYS IMMEDIATELY
PRECEDING ANY CLOSING DATE OR (II) THE FIVE CONSECUTIVE TRADING DAYS IMMEDIATELY
PRECEDING ANY CLOSING DATE,  WHICHEVER IS THE LOWEST. THE WARRANT EXERCISE PRICE
IS SUBJECT TO ANTIDILUTION  ADJUSTMENTS UNDER CERTAIN  CUSTOMARY  CIRCUMSTANCES,
INCLUDING BELOW MARKET AND/OR EXERCISE PRICE ISSUANCES. THE WARRANTS ARE SUBJECT
TO  REDEMPTION  BY THE COMPANY AT $.01 PER SHARE FOR EACH SHARE  SUBJECT TO EACH
WARRANT  ON 60  DAYS'  PRIOR  WRITTEN  NOTICE,  PROVIDED  THAT THE  CLOSING  BID
QUOTATION FOR THE COMMON STOCK AS REPORTED ON THE NASDAQ, OR ON SUCH EXCHANGE ON
WHICH THE COMMON  STOCK IS THEN TRADED OR LISTED,  EXCEEDS  300% OF THE EXERCISE
PRICE PER SHARE FOR 20  CONSECUTIVE  TRADING DAYS ENDING THREE DAYS PRIOR TO THE
DATE OF THE NOTICE OF REDEMPTION. THE WARRANTS ARE NOT REDEEMABLE ON OR PRIOR TO
THE FIRST ANNIVERSARY OF THEIR ISSUANCE OR AT ANY TIME THAT ANY SHARES OF SERIES
A  PREFERRED  STOCK  REMAIN  OUTSTANDING.  NOTWITHSTANDING  THE  FOREGOING,  THE
WARRANTS ARE REDEEMABLE AFTER THE FIRST ANNIVERSARY REGARDLESS OF WHETHER ANY OR
ALL OF THE SERIES A  PREFERRED  STOCK  REMAINS  OUTSTANDING  IF THE  CLOSING BID
QUOTATION FOR THE COMMON STOCK AS REPORTED ON THE NASDAQ, OR ON SUCH EXCHANGE ON
WHICH THE COMMON  STOCK IS THEN TRADED OR LISTED,  EXCEEDS  600% OF THE EXERCISE
PRICE PER SHARE FOR 20  CONSECUTIVE  TRADING DAYS ENDING THREE DAYS PRIOR TO THE
DATE OF THE NOTICE OF  REDEMPTION.  THE COMPANY WILL PAY THE  PLACEMENT  AGENT A
COMMISSION OF 5% UPON THE EXERCISE OF ANY OF THE WARRANTS,  THE NEW WARRANTS AND
THE BRIDGE WARRANTS.  THE PLACEMENT AGENT MAY ALLOW A PORTION OF THIS COMMISSION
TO MEMBERS IN GOOD  STANDING OF THE NASD.  ANY COSTS  INCURRED BY THE  PLACEMENT
AGENT IN CONNECTION WITH THE SOLICITATION OF WARRANT EXERCISES OR THE REDEMPTION
OF WARRANTS SHALL BE BORNE BY THE COMPANY.

         8.  PENDING  COMPLETION  OF  THE  OFFERING  AND  FOR  A 30  DAY  PERIOD
THEREAFTER,  THE  COMPANY  WILL NOT  ISSUE  PRESS  RELEASES  OR  ENGAGE IN OTHER
PUBLICITY  WITHOUT  ADVISING THE PLACEMENT  AGENT IN ADVANCE.  THE COMPANY SHALL
MAKE A RULE 135(C) (UNDER THE SECURITIES  ACT OF 1933, AS AMENDED)  ANNOUNCEMENT
PRIOR TO THE  COMMENCEMENT OF THE OFFERING.  DURING THE 18 MONTHS  FOLLOWING THE
CLOSING OF THE BRIDGE LOAN,  THE COMPANY  SHALL NOT,  WITHOUT THE PRIOR  WRITTEN
CONSENT OF THE PLACEMENT AGENT,  OFFER OR SELL ANY OF ITS SECURITIES IN RELIANCE
ON REGULATION S OF THE SECURITIES  ACT OF 1933, AS AMENDED.  DURING THE 18 MONTH
PERIOD FOLLOWING THE CLOSING OF THE BRIDGE LOAN, THE PLACEMENT AGENT


                                      -2-


<PAGE>

SHALL HAVE THE RIGHT OF FIRST REFUSAL TO ACT AS PLACEMENT  AGENT FOR THE PRIVATE
OFFERING OF ANY SECURITIES OF THE COMPANY.  DURING THE 36 MONTH PERIOD FOLLOWING
THE CLOSING OF THE BRIDGE LOAN (AS DEFINED IN PARAGRAPH  14 BELOW),  THE COMPANY
WILL NOT EXTEND THE  EXPIRATION  DATE OR LOWER THE  EXERCISE  OR THE  CONVERSION
PRICE OF ANY  OPTIONS,  WARRANTS OR  CONVERTIBLE  SECURITIES,  WITHOUT THE PRIOR
WRITTEN CONSENT OF THE PLACEMENT  AGENT.  DURING THE 5 YEAR PERIOD FOLLOWING THE
CLOSING  OF THE  BRIDGE  LOAN,  THE  PLACEMENT  AGENT  SHALL  HAVE THE  RIGHT TO
DESIGNATE A MAJORITY OF THE  DIRECTORS OR OBSERVERS TO THE BOARD OF DIRECTORS OF
THE  COMPANY;  PROVIDED,  HOWEVER,  THAT IN THE EVENT THAT THE  COMPANY  HAS NOT
OBTAINED  FUTURE  FINANCINGS  (AS DEFINED  BELOW) IN EXCESS OF  $3,500,000 ON OR
BEFORE THE DATE WHICH IS 6 MONTHS  AFTER THE BRIDGE  CLOSING DATE (AS DEFINED IN
EXHIBIT B),  THEN THE  PLACEMENT  AGENT  SHALL HAVE THE RIGHT TO APPOINT  ONLY 2
DIRECTORS OR OBSERVERS  AND THE REMAINDER OF THE  PLACEMENT  AGENT'S  DESIGNATED
DIRECTORS  SHALL RESIGN.  IN ADDITION,  IF THE HOLDERS OF THE SERIES A PREFERRED
STOCK EXERCISE THEIR RIGHT TO APPOINT UP TO 2 ADDITIONAL  DIRECTORS  PURSUANT TO
SECTION 9(C) OF THE RESTATED  CERTIFICATE OF  INCORPORATION  OF THE COMPANY (THE
"RESTATED  CERTIFICATE"),  THEN THE  PLACEMENT  AGENT  SHALL  HAVE THE  RIGHT TO
APPOINT UP TO 2  ADDITIONAL  DIRECTORS  PER  DIRECTOR  APPOINTED BY THE SERIES A
PREFERRED STOCK AND, IF REQUESTED BY THE PLACEMENT  AGENT, THE COMPANY SHALL USE
ITS BEST EFFORTS TO OBTAIN THE  RESIGNATIONS  FROM THE BOARD OF DIRECTORS OF ANY
DIRECTORS  SPECIFIED BY THE PLACEMENT  AGENT. THE COMPANY SHALL NOT USE THE NAME
OF THE PLACEMENT AGENT OR ANY OFFICER, DIRECTOR, EMPLOYEE OR SHAREHOLDER WITHOUT
THE EXPRESS WRITTEN CONSENT OF THE PLACEMENT AGENT AND SUCH PERSON.

         "FUTURE  FINANCINGS"  SHALL MEAN THE  AGGREGATE  GROSS  PROCEEDS OF ANY
SALES OF EQUITY  SECURITIES  OF THE  COMPANY  (INCLUDING  THE NOTES OR ANY OTHER
SECURITIES CONVERTIBLE INTO EQUITY SECURITIES OF THE COMPANY), AND THE AGGREGATE
GROSS PROCEEDS OF ANY CORPORATE PARTNERING OR CORPORATE LICENSING  TRANSACTIONS,
BUT SHALL  EXCLUDE THE SALE OF PRODUCTS IN THE  ORDINARY  COURSE OF BUSINESS AND
REVENUES  RESULTING  FROM ANY AGREEMENT IN EFFECT AS OF THE BRIDGE CLOSING DATE.
WITHOUT  LIMITING  THE  GENERALITY  OF  THE  FOREGOING,  SUCH  FUTURE  FINANCING
INCLUDES: (A) ALL PAYMENTS MADE FOR EQUITY SECURITIES, EQUITY SECURITY RIGHTS OR
SIMILAR RIGHTS,  (B) TECHNOLOGY  ACQUISITION OR ACCESS FEES OR SIMILAR  UP-FRONT
PAYMENTS,  (C) OTHER FUTURE PAYMENTS TO BE MADE TO THE  CORPORATION,  ANY OF ITS
AFFILIATES OR ITS EMPLOYEES  FOR THE BENEFIT OF THE  CORPORATION,  FOR WHICH THE
PAYOR IS OBLIGATED EITHER  ABSOLUTELY OR UPON THE ATTAINMENT OF MILESTONES,  (D)
FUNDING PROVIDED BY ANY INVESTOR (THROUGH  REIMBURSEMENT OR OTHERWISE)  RELATIVE
TO RESEARCH AND DEVELOPMENT, CLINICAL TRIALS AND RELATED EXPENDITURES,  PROVIDED
THAT  SUCH  WORK  IS  PERFORMED  OR  MANAGED  BY THE  CORPORATION  OR ANY OF ITS
AFFILIATES  AND (E) THE REPAYMENT OR ASSUMPTION BY ANY PARTY OF  OBLIGATIONS  OF
THE CORPORATION ANY OF ITS AFFILIATES, INCLUDING INDEBTEDNESS FOR MONEY BORROWED
OR AMOUNTS  OWED BY THE  CORPORATION  OR ANY OF ITS  AFFILIATES  TO INVENTORS OR
OWNERS OF TECHNOLOGY.  IT IS FURTHER UNDERSTOOD THAT FUTURE FINANCINGS SHALL NOT
BE  REDUCED  BY THE  AMOUNT OF ANY  EXPENSES,  FEES,  DISCOUNTS  OR  COMMISSIONS
INCURRED DURING THE UNDERTAKING OF SUCH FINANCING.

         9. THE COMPANY  SHALL BE  RESPONSIBLE  FOR AND SHALL BEAR ALL  EXPENSES
DIRECTLY AND  NECESSARILY  INCURRED IN  CONNECTION  WITH THE PROPOSED  OFFERING,
INCLUDING BUT NOT LIMITED TO, THE COSTS OF PREPARING AND PRINTING THE MEMORANDUM
AND ALL EXHIBITS THERETO;  PREPARING,  PRINTING AND DELIVERING  EXHIBITS THERETO
AND COPIES OF THE PRELIMINARY,  FINAL AND SUPPLEMENTAL PROSPECTUS;  THE COSTS OF
PREPARING,  PRINTING AND FILING WITH THE SECURITIES AND EXCHANGE COMMISSION (THE
"SEC")  THE  SHELF   REGISTRATION   STATEMENT  AND  AMENDMENTS,   POST-EFFECTIVE
AMENDMENTS AND SUPPLEMENTS THERETO; PREPARING,  PRINTING AND DELIVERING EXHIBITS
THERETO  AND  COPIES  OF THE  PRELIMINARY,  FINAL AND  SUPPLEMENTAL  PROSPECTUS;
PREPARING,  PRINTING AND  DELIVERING  ALL SELLING  DOCUMENTS,  INCLUDING BUT NOT
LIMITED TO THE PLACEMENT  AGENCY  AGREEMENT,  SUBSCRIPTION  AGREEMENTS,  WARRANT
AGREEMENTS,  BLUE SKY  MEMORANDUM AND STOCK AND WARRANT  CERTIFICATES;  BLUE SKY
FEES,  FILING FEES AND LEGAL FEES AND DISBURSEMENTS OF OUR COUNSEL IN CONNECTION
WITH BLUE SKY MATTERS; FEES AND DISBURSEMENTS OF THE TRANSFER AND WARRANT AGENT;
THE COST OF A TOTAL OF TWO SETS OF BOUND CLOSING VOLUMES FOR THE PLACEMENT AGENT
AND ITS COUNSEL; AND THE COST OF THREE TOMBSTONE ADVERTISEMENTS, AT LEAST ONE OF
WHICH SHALL BE IN A NATIONAL  BUSINESS  NEWSPAPER AND ONE OF WHICH SHALL BE IN A
MAJOR NEW YORK  NEWSPAPER (OR AT THE PLACEMENT  AGENT'S  OPTION,  40 LUCITE DEAL
MEMENTOS)(COLLECTIVELY,  THE "COMPANY  EXPENSES").  THE COMPANY  AGREES TO USE A
PRINTER DESIGNATED BY THE PLACEMENT AGENT AND WHICH IS REASONABLY  ACCEPTABLE TO
THE COMPANY.  THE COMPANY  SHALL PAY TO THE  PLACEMENT  AGENT A  NON-ACCOUNTABLE
EXPENSE  ALLOWANCE  EQUAL  TO 4% OF THE  TOTAL  PROCEEDS  OF THE  OFFERING  (THE
"EXPENSE  ALLOWANCE"),  OF  WHICH  $20,000  SHALL  BE DUE AND  PAYABLE  UPON THE
EXECUTION OF THIS LETTER OF INTENT AND OF WHICH ANOTHER $20,000 SHALL BE DUE AND
PAYABLE UPON THE DATE THAT THE  


                                       -3-


<PAGE>

MEMORANDUM IS COMPLETED (BOTH OF WHICH $20,000 PAYMENTS SHALL BE CREDITED TO THE
COMPANY AND OFFSET AGAINST THE TOTAL EXPENSE ALLOWANCE DUE THE PLACEMENT AGENT),
TO COVER THE COST OF OUR MAILING,  TELEPHONE,  TELEGRAPH,  TRAVEL, DUE DILIGENCE
MEETINGS AND OTHER SIMILAR  EXPENSES  INCLUDING LEGAL FEES OF OUR COUNSEL (OTHER
THAN LEGAL FEES IN  CONNECTION  WITH BLUE SKY MATTERS AS TO WHICH FEES YOU SHALL
BE RESPONSIBLE). SUCH PREPAID EXPENSE ALLOWANCES SHALL BE NON-REFUNDABLE. IF THE
PROPOSED  FINANCING IS NOT COMPLETED  BECAUSE THE COMPANY PREVENTS IT OR BECAUSE
OF A BREACH BY THE  COMPANY  OF ANY  COVENANTS,  REPRESENTATIONS  OR  WARRANTIES
CONTAINED HEREIN, THE COMPANY SHALL PAY TO THE PLACEMENT AGENT A FEE OF $100,000
(IN ADDITION TO THE COMPANY  EXPENSES FOR WHICH THE COMPANY  SHALL IN ALL EVENTS
REMAIN  LIABLE).  IN ADDITION,  THE COMPANY SHALL BE  RESPONSIBLE  FOR AND SHALL
REIMBURSE THE PLACEMENT  AGENT AND/OR THE  PARTNERSHIP AND THE TRUST (AS DEFINED
IN PARAGRAPH 16 BELOW) FOR ALL COSTS INCURRED IN CONNECTION WITH THE BRIDGE LOAN
(INCLUDING, WITHOUT LIMITATION,  ATTORNEY'S FEES, EXPENSES AND DISBURSEMENTS) IN
AN AGGREGATE AMOUNT NOT TO EXCEED $35,000  PROVIDED,  HOWEVER,  THAT THE $35,000
CAP ON COST REIMBURSEMENT SHALL APPLY ONLY TO THE ACTUAL BRIDGE LOAN TRANSACTION
AND NOT TO ANY COSTS  INCURRED  AS A RESULT OF THE  REGISTRATION  OF  SECURITIES
ACQUIRED IN SUCH  TRANSACTION  UNDER THE FEDERAL AND STATE SECURITIES LAWS WHICH
SUCH COSTS, AS SET FORTH HEREIN, SHALL BE THE RESPONSIBILITY OF THE COMPANY.

         10. UPON THE FINAL CLOSING OF THE SALE OF THE UNITS BEING OFFERED,  THE
COMPANY WILL GRANT TO THE PLACEMENT AGENT AND/OR ITS DESIGNEES (I) WARRANTS (THE
"PLACEMENT  WARRANTS")  TO PURCHASE  ADDITIONAL  UNITS EQUAL TO 10% OF THE UNITS
SOLD IN THE  OFFERING  EXERCISABLE  FOR A PERIOD OF FIVE  YEARS  COMMENCING  SIX
MONTHS AFTER THE FINAL  CLOSING  DATE AT AN EXERCISE  PRICE EQUAL TO 110% OF THE
INITIAL  OFFERING PRICE OF THE UNITS.  THE  SECURITIES  UNDERLYING THE PLACEMENT
WARRANTS  WILL NOT BE SUBJECT  TO  MANDATORY  CONVERSION  OR  REDEMPTION  BY THE
COMPANY NOR WILL THEY BE CALLABLE BY THE COMPANY.  THE PLACEMENT WARRANTS CANNOT
BE TRANSFERRED,  SOLD,  ASSIGNED OR HYPOTHECATED FOR SIX MONTHS EXCEPT THAT THEY
MAY BE  ASSIGNED  IN WHOLE OR IN PART  DURING  SUCH  PERIOD  TO ANY NASD  MEMBER
PARTICIPATING  IN THE OFFERING OR ANY OFFICER OR EMPLOYEE OF THE PLACEMENT AGENT
OR ANY SUCH NASD MEMBER. THE PLACEMENT WARRANTS WILL CONTAIN A CASHLESS EXERCISE
FEATURE,  ANTIDILUTION  PROVISIONS  AND THE  RIGHT  TO HAVE  THE  RESALE  OF THE
SECURITIES  UNDERLYING THE PLACEMENT WARRANTS INCLUDED ON THE SHELF REGISTRATION
STATEMENT.

         11. IF REQUESTED BY THE PLACEMENT  AGENT,  THE COMPANY WILL OBTAIN FROM
THE EXECUTIVE  OFFICERS AND DIRECTORS OF THE COMPANY,  AND WILL USE BEST EFFORTS
TO OBTAIN FROM ITS 5%  STOCKHOLDERS,  AN AGREEMENT  THAT,  FOR A PERIOD OF UP TO
TWENTY-FOUR MONTHS FROM THE CLOSING OF THE OFFERING,  THEY WILL NOT SELL, ASSIGN
OR  TRANSFER  ANY OF  THEIR  SHARES  OF THE  COMPANY'S  SECURITIES  WITHOUT  THE
PLACEMENT AGENT'S PRIOR WRITTEN CONSENT. IN ADDITION,  THE COMPANY WILL COVENANT
TO USE ITS BEST EFFORTS TO OBTAIN THE REQUISITE  SHAREHOLDER APPROVALS NECESSARY
TO CONSUMMATE THE OFFERINGS AND RELATED  TRANSACTIONS  AS  CONTEMPLATED  BY THIS
LETTER OF INTENT AS SOON AS POSSIBLE FOLLOWING THE CLOSING OF THE BRIDGE LOAN.

         12. THE CASH COMMISSIONS, EXPENSES ALLOWANCE AND PLACEMENT AND ADVISORY
WARRANTS  AS SET  FORTH  IN THIS  LETTER  OF  INTENT  WILL  APPLY  TO  INVESTORS
INTRODUCED  TO THE  COMPANY BY THE  PLACEMENT  AGENT WHO  INVEST IN THE  COMPANY
DURING THE TWELVE MONTHS  FOLLOWING  THE FINAL CLOSING DATE OF THE OFFERING.  IN
ADDITION,  UPON THE CLOSING OF THE BRIDGE  LOAN,  THE COMPANY AND THE  PLACEMENT
AGENT WILL ENTER INTO AN ENGAGEMENT  AGREEMENT WHEREBY PARAMOUNT WILL ACT AS THE
COMPANY'S  NON-EXCLUSIVE  FINANCIAL  ADVISOR.  SUCH  ENGAGEMENT  AGREEMENT  WILL
PROVIDE THAT THE PLACEMENT  AGENT RECEIVE A MONTHLY  RETAINER OF $4,000 (MINIMUM
ENGAGEMENT OF TWENTY-FOUR MONTHS),  OUT-OF-POCKET  EXPENSES AND STANDARD SUCCESS
FEES. IN ADDITION,  UPON COMPLETION OF THE OFFERING AND PURSUANT TO THE TERMS OF
SUCH ENGAGEMENT  AGREEMENT,  THE COMPANY WILL SELL TO THE PLACEMENT AGENT AND/OR
ITS DESIGNEES,  FOR $.001 PER WARRANT SHARE,  WARRANTS (THE "ADVISORY WARRANTS")
TO  PURCHASE  ADDITIONAL  UNITS  EQUAL TO 15% OF THE UNITS SOLD IN THE  OFFERING
EXERCISABLE  FOR A PERIOD OF FIVE YEARS  COMMENCING  SIX MONTHS  AFTER THE FINAL
CLOSING DATE AT AN EXERCISE PRICE EQUAL TO 110% OF THE INITIAL  OFFERING  PRICE.
THE SECURITIES UNDERLYING THE ADVISORY WARRANTS WILL NOT BE SUBJECT TO MANDATORY
CONVERSION  OR  REDEMPTION  BY THE  COMPANY  NOR WILL  THEY BE  CALLABLE  BY THE
COMPANY.  THE  ADVISORY  WARRANTS  WILL  CONTAIN A  CASHLESS  EXERCISE  FEATURE,
ANTIDILUTION  PROVISIONS  AND THE RIGHT TO HAVE THE  SECURITIES  UNDERLYING  THE
ADVISORY WARRANTS INCLUDED ON THE SHELF REGISTRATION STATEMENT.

         13.  THE  COMPANY  SHALL  NOT USE ANY  PROCEEDS  FROM THE  OFFERING  TO
REPURCHASE,  REDEEM OR OTHERWISE  ACQUIRE ANY SHARES OF SERIES A PREFERRED STOCK
OR TO REPAY ANY  INDEBTEDNESS  OF THE COMPANY,  INCLUDING BUT NOT LIMITED TO ANY
INDEBTEDNESS  TO CURRENT  


                                       -4-


<PAGE>

EXECUTIVE  OFFICERS OR  PRINCIPAL  STOCKHOLDERS  OF THE COMPANY,  BUT  EXCLUDING
ACCOUNTS PAYABLE INCURRED IN THE ORDINARY COURSE. IN ADDITION, THE COMPANY SHALL
NOT FOR A PERIOD OF 5 YEARS FROM THE INITIAL  CLOSING DATE  OPTIONALLY  AGREE TO
REPURCHASE,  REDEEM OR OTHERWISE  ACQUIRE THE SHARES OF SERIES A PREFERRED STOCK
FOR CASH,  INCLUDING,  WITHOUT LIMITATION,  IN THE EVENT OF A FUNDAMENTAL CHANGE
PURSUANT  TO  THE  RESTATED   CERTIFICATE  AS  SUCH  TERM  IS  DEFINED  THEREIN.
ADDITIONALLY,  PROCEEDS FROM THE BRIDGE LOAN RECEIVED BY THE COMPANY MAY BE USED
BY THE COMPANY AS WORKING CAPITAL IN THE ORDINARY COURSE OF BUSINESS.

         14. AS  EXPEDITIOUSLY  AS  PRACTICABLE  FOLLOWING THE EXECUTION OF THIS
LETTER  OF INTENT  BUT NO LATER  THAN  FEBRUARY  7,  1996,  AND  SUBJECT  TO THE
COMPLETION  OF  NECESSARY  CORPORATE  AND LEGAL DUE  DILIGENCE  (AS TO WHICH THE
PLACEMENT  AGENT SHALL BE THE SOLE JUDGE),  THE  PLACEMENT  AGENT SHALL SERVE AS
PLACEMENT AGENT, ON A "BEST EFFORTS" BASIS, OF A PRIVATE  PLACEMENT (THE "BRIDGE
LOAN") OF $3,000,000 OF SENIOR  SECURED  PROMISSORY  NOTES ISSUED BY THE COMPANY
(THE "BRIDGE  NOTES") AND WARRANTS  (THE  "BRIDGE  WARRANTS"),  ON THE TERMS AND
CONDITIONS CONTAINED IN EXHIBIT B HERETO.  SUBJECT TO THE IMMEDIATELY SUCCEEDING
SENTENCE,  IN  CONNECTION  WITH THE BRIDGE LOAN,  THE  PLACEMENT  AGENT SHALL BE
ENTITLED TO: (X) A COMMISSION  EQUAL TO 9% OF THE TOTAL PROCEEDS  RESULTING FROM
THE SALE OF THE BRIDGE  UNITS AND (Y)  WARRANTS TO PURCHASE 10% OF THE SHARES OF
COMMON STOCK UNDERLYING THE BRIDGE WARRANTS AND THE COMPANY SHALL BE RESPONSIBLE
FOR ALL APPLICABLE COMPANY EXPENSES.  THERE SHALL BE NO EXPENSE ALLOWANCE AND NO
ADVISORY WARRANT COMPENSATION IN CONNECTION WITH THE BRIDGE LOAN.

         15. THE PLACEMENT AGENT RECOGNIZES THE COMPANY'S  CONCERNS WITH RESPECT
TO  THE  ANTISENSE  PROGRAM  AND  FUTURE  FINANCING  PRICING  AND  ALTERNATIVES.
ACCORDINGLY,  THE  PLACEMENT  AGENT  AGREES (I) THAT TO THE  EXTENT  ALTERNATIVE
FINANCINGS ARE AVAILABLE  OTHER THAN THE OFFERING AT BETTER TIMING,  PRICING AND
TERMS,  THEN THE PLACEMENT  AGENT SHALL WAIVE ITS RIGHT TO CONDUCT THE OFFERING,
ITS RIGHT TO RECEIVE  COMPENSATION  THEREFOR  AND ITS RIGHT OF FIRST  REFUSAL AS
DESCRIBED IN PARAGRAPH 8 AND (II) TO USE ITS REASONABLE BEST EFFORTS TO MAINTAIN
THE ANTISENSE PROGRAM. IT IS NOT THE CURRENT INTENTION OF THE PLACEMENT AGENT TO
LIQUIDATE THE COMPANY.

         16.  SUBJECT TO THE  COMPLETION  OF NECESSARY  CORPORATE  AND LEGAL DUE
DILIGENCE  AND THE  EXECUTION OF DEFINITIVE  DOCUMENTATION  SATISFACTORY  TO THE
ARIES DOMESTIC FUND, L.P. (THE "PARTNERSHIP") AND THE ARIES TRUST (THE "TRUST"),
IN THEIR SOLE DISCRETION, THE PARTNERSHIP AND THE TRUST SHALL PARTICIPATE IN THE
BRIDGE  LOAN  REFERENCED  IN  PARAGRAPH  14  IN  AN  AGGREGATE  AMOUNT  OF UP TO
$3,000,000  AND  SHALL BE  ENTITLED  TO  REIMBURSEMENT  FOR  COSTS  INCURRED  IN
CONNECTION WITH THE BRIDGE LOAN AS PROVIDED IN PARAGRAPH 9 HEREOF.

         THE  FOREGOING IS ONLY A BRIEF  OUTLINE OF THE PROPOSED  FINANCING  AND
EACH OF THE FOREGOING  TERMS MUST BE INTERPRETED IN THE FORM IN WHICH IT FINALLY
APPEARS IN THE PROPOSED  PLACEMENT  AGENCY AGREEMENT AND RELATED  DOCUMENTS.  WE
WILL,  OF COURSE,  CONTINUE TO CONDUCT OUR DUE  DILIGENCE  INVESTIGATION  OF THE
COMPANY  UNTIL THE OFFERING IS COMPLETED,  AND SUCH DUE DILIGENCE  INVESTIGATION
SHALL, IN ALL EVENTS,  BE SUBJECT TO OUR SATISFACTION AS TO WHICH WE SHALL BE TO
SOLE JUDGE. WHILE IT IS THE INTENTION OF THE PARTIES HERETO THAT THE OFFERING OF
THE  COMPANY'S  UNITS BE MADE,  THIS LETTER  CANNOT IN ANY WAY BE CONSTRUED AS A
COMMITMENT  BY US TO COMPLETE THE PLACEMENT OF THE UNITS AND WE MAY, IN OUR SOLE
JUDGEMENT  AND  DISCRETION,  DETERMINE  AT ANY  TIME  NOT TO  PROCEED  WITH  THE
OFFERING.  THIS LETTER SHALL BE  CONDITIONED  IN ITS ENTIRETY UPON THE EXECUTION
AND DELIVERY OF A SATISFACTORY  PLACEMENT AGENCY  AGREEMENT  BETWEEN THE COMPANY
AND US (AND THIS  LETTER IS NOT TO BE  CONSTRUED  AS SUCH A  CONTRACT  NOR AS AN
AGREEMENT TO ENTER INTO SUCH CONTRACTS) TO BE ENTERED INTO IMMEDIATELY  PRIOR TO
THE TIME OF THE OFFERING AND SHALL BE CONDITIONED FURTHER UPON COMPLIANCE BY THE
COMPANY  WITH THE TERMS  CONTAINED IN THIS LETTER AND IN SUCH  PLACEMENT  AGENCY
AGREEMENT.  NOTWITHSTANDING THE FOREGOING, THE PROVISIONS OF PARAGRAPHS 4, 8 AND
9 HEREOF  SHALL,  HOWEVER,  BE  EFFECTIVE  AND BINDING UPON THE COMPANY UPON THE
EXECUTION HEREOF.


                                       -5-


<PAGE>

         IF THE FOREGOING CONFORMS TO YOUR UNDERSTANDING,  PLEASE SIGN, DATE AND
RETURN TO US THE ENCLOSED COPY OF THIS LETTER.

                                       VERY TRULY YOURS,

                                       PARAMOUNT CAPITAL, INC.


                                       BY: /s/Lindsay A. Rosenwald
                                           ---------------------------
                                           LINDSAY A. ROSENWALD, M.D.
                                           CHAIRMAN

THE FOREGOING IS IN CONFORMITY
WITH OUR UNDERSTANDING:

GENTA INCORPORATED


BY: /s/Thomas Adams
    -----------------------
    THOMAS ADAMS
    PRESIDENT AND CHIEF EXECUTIVE OFFICER


FOR PURPOSES OF PARAGRAPHS 9 AND 16 ONLY:

ARIES DOMESTIC FUND, L.P.


BY: /s/Lindsay A. Rosenwald
    -----------------------
    LINDSAY A. ROSENWALD, M.D.
    PRESIDENT, PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.
    GENERAL PARTNER OF ARIES DOMESTIC FUND, L.P.


FOR PURPOSES OF PARAGRAPHS 9 AND 16 ONLY:

THE ARIES TRUST

BY: /s/Lindsay A. Rosenwald
    -----------------------
    LINDSAY A. ROSENWALD, M.D.
    PRESIDENT, PARAMOUNT CAPITAL ASSET MANAGEMENT, INC


                                       -6-


<PAGE>

                                                                       EXHIBIT A


               RIGHTS AND PREFERENCES OFSERIES D PREFERRED STOCKTM


SERIES D PREFERRED STOCK

THE COMPANY WILL FILE A CERTIFICATE OF DESIGNATION  DESIGNATING 3,750,000 SHARES
OF PREFERRED STOCK AS SERIES D PREFERRED STOCK (THE "PREFERRED  STOCK").  GIVING
EFFECT TO THE SALE OF THE MINIMUM  OFFERING,  25,000  SHARES OF PREFERRED  STOCK
WILL BE FULLY PAID, VALIDLY ISSUED AND NON-ASSESSABLE. GIVING EFFECT TO THE SALE
OF THE MAXIMUM  OFFERING,  75,000 SHARES OF PREFERRED  STOCK WILL BE FULLY PAID,
VALIDLY ISSUED AND NON-ASSESSABLE. THE STATED VALUE PER SHARE OF PREFERRED STOCK
SHALL BE $10.00.

         VOTING

THE HOLDERS OF THE  PREFERRED  STOCK WILL HAVE THE RIGHT AT ALL  MEETINGS OF THE
STOCKHOLDERS  TO THAT  NUMBER OF VOTES  EQUAL TO THE  NUMBER OF SHARES OF COMMON
STOCK  ISSUABLE  UPON  CONVERSION  OF SUCH  SHARES  AT THE  RECORD  DATE FOR THE
DETERMINATION  OF THE  STOCKHOLDERS  ENTITLED TO VOTE ON SUCH  MATTERS OR, IF NO
SUCH RECORD DATE IS  ESTABLISHED,  AT THE DATE SUCH VOTE IS TAKEN.  AS LONG AS A
MAJORITY OF THE SHARES OF  PREFERRED  STOCK REMAIN  OUTSTANDING,  THE HOLDERS OF
66-2/3% OF THE OUTSTANDING SHARES OF THE PREFERRED STOCK WILL BE ENTITLED TO (I)
APPROVE ANY  SECURITIES  ISSUED BY THE COMPANY  WHICH ARE SENIOR TO OR ON PARITY
WITH THE PREFERRED STOCK WITH RESPECT TO LIQUIDATION OR DIVIDENDS,  (II) APPROVE
ANY  SECURITIES  ISSUED BY THE COMPANY WHICH ARE SENIOR TO THE  PREFERRED  STOCK
WITH RESPECT TO VOTING (EXCEPT FOR CLASS VOTING RIGHTS  REQUIRED BY LAW),  (III)
APPROVE ANY ALTERATION OR CHANGE TO THE RIGHTS, PREFERENCES OR PRIVILEGES OF THE
PREFERRED   STOCK,   (IV)  APPROVE  ANY   LIQUIDATION,   DISSOLUTION,   SALE  OF
SUBSTANTIALLY ALL OF THE ASSETS OF THE COMPANY, (V) APPROVE THE INCORPORATION OF
ANY SUBSIDIARY  COMPANY,  (VI) APPROVE ANY TRANSACTIONS  BETWEEN THE COMPANY AND
ITS  AFFILIATES  AND (VII)  APPROVE THE ISSUANCE OF ANY DEBT  SECURITIES  OF THE
COMPANY IN EXCESS IN THE AGGREGATE OF $50,000.

         DIVIDENDS

THE HOLDERS OF THE  PREFERRED  STOCK SHALL BE ENTITLED TO RECEIVE  DIVIDENDS AS,
WHEN AND IF DECLARED BY THE BOARD OF DIRECTORS  OUT OF FUNDS  LEGALLY  AVAILABLE
THEREFOR. NO DIVIDEND OR DISTRIBUTION,  AS THE CASE MAY BE, SHALL BE DECLARED OR
PAID ON ANY JUNIOR  STOCK  UNLESS THE SAME IS PAID TO THE  PREFERRED  STOCK.  IN
ADDITION, FOLLOWING THE RESET DATE AS DEFINED BELOW, THE PREFERRED STOCK WILL BE
ENTITLED TO A PAYMENT-IN-KIND DIVIDEND OF 10% PER ANNUM, PAYABLE ANNUALLY.

         LIQUIDATION

UPON (I) A  LIQUIDATION,  DISSOLUTION,  OR  WINDING UP OF THE  COMPANY,  WHETHER
VOLUNTARY  OR  INVOLUNTARY  OR  (II)  A  SALE  OR  OTHER  DISPOSITION  OF ALL OR
SUBSTANTIALLY  ALL OF THE ASSETS OF THE COMPANY (A "LIQUIDATION  EVENT"),  AFTER
PAYMENT  OR  PROVISION  FOR  PAYMENT OF THE DEBTS AND OTHER  LIABILITIES  OF THE
COMPANY,  THE  HOLDERS OF THE  PREFERRED  STOCK THEN  OUTSTANDING  WILL FIRST BE
ENTITLED  TO  RECEIVE,  PRO RATA (ON THE  BASIS OF THE  NUMBER  OF SHARES OF THE
PREFERRED  STOCK THEN  OUTSTANDING),  ON A PARI  PASSU  BASIS WITH THE SHARES OF
SERIES A PREFERRED  STOCK AND IN  PREFERENCE  TO THE HOLDERS OF THE COMMON STOCK
AND ANY OTHER SERIES OF PREFERRED  STOCK,  AN AMOUNT PER SHARE EQUAL TO $14 PLUS
ACCRUED BUT UNPAID  DIVIDENDS,  IF ANY.  MERGERS  AND SIMILAR  EVENTS IN WHICH A
MAJORITY OF THE VOTING  CONTROL OF THE COMPANY'S  CAPITAL  STOCK IS  TRANSFERRED
WILL BE TREATED SIMILARLY WITH RESPECT TO THE MERGER CONSIDERATION.

         CONVERSION

THE PREFERRED STOCK WILL BE CONVERTED INTO COMMON STOCK AT AN INITIAL CONVERSION
PRICE  EQUAL TO THE LESSER OF (I) $.30 AND (II) 50% OF THE  AVERAGE  CLOSING BID
PRICE OF THE COMMON STOCK FOR EITHER THE THIRTY CONSECUTIVE  TRADING DAYS OR THE
FIVE CONSECUTIVE  TRADING DAYS (THE "TRADING PRICE")  IMMEDIATELY  PRECEDING (A)
THE INITIAL CLOSING DATE (THE "INITIAL  CLOSING DATE"),  (B) ANY INTERIM CLOSING
DATE (EACH AN "INTERIM  CLOSING DATE") OR (C) THE FINAL CLOSING DATE (THE "FINAL
CLOSING DATE") OF THIS OFFERING,  WHICHEVER IS THE 


                                       -7-


<PAGE>

LOWEST,  SUBJECT TO  ADJUSTMENT  AS SET FORTH BELOW (THE  "PREFERRED  CONVERSION
PRICE"), REPRESENTING AN INITIAL CONVERSION RATE OF [].

THE  PREFERRED  STOCK MAY BE  CONVERTED  AT THE OPTION OF THE HOLDER AT ANY TIME
AFTER  THE  INITIAL  ISSUANCE  DATE  OF  THE  PREFERRED  STOCK  FOR  FULLY  PAID
NONASSESSABLE  SHARES OF COMMON STOCK. THE PREFERRED CONVERSION PRICE IS SUBJECT
TO ADJUSTMENT  UPON THE OCCURRENCE OF A MERGER,  REORGANIZATION,  CONSOLIDATION,
RECLASSIFICATION, STOCK DIVIDEND OR STOCK SPLIT WHICH WILL RESULT IN AN INCREASE
OR DECREASE IN THE NUMBER OF SHARES OF
COMMON STOCK OUTSTANDING.

IN ADDITION,  THE CONVERSION PRICE IN EFFECT  IMMEDIATELY PRIOR TO THE DATE THAT
IS 12 MONTHS AFTER THE FINAL  CLOSING  DATE (THE "RESET  DATE") WILL BE ADJUSTED
AND RESET EFFECTIVE AS OF THE RESET DATE IF THE AVERAGE CLOSING PRICE FOR THE 20
CONSECUTIVE  TRADING DAYS  IMMEDIATELY  PRECEDING THE RESET DATE (THE  "12-MONTH
TRADING  PRICE") IS LESS THAN 140% OF THE THEN APPLICABLE  PREFERRED  CONVERSION
PRICE  (A  "RESET  EVENT").  UPON  THE  OCCURRENCE  OF A RESET  EVENT,  THE THEN
APPLICABLE PREFERRED CONVERSION PRICE WILL BE REDUCED TO BE EQUAL TO THE GREATER
OF (I) THE  12-MONTH  TRADING  PRICE  DIVIDED  BY 1.4 AND  (II)  25% OF THE THEN
APPLICABLE PREFERRED CONVERSION PRICE.

         MANDATORY CONVERSION

UNLESS CONVERTED EARLIER,  THE COMPANY HAS THE RIGHT AT ANY TIME AFTER THE RESET
DATE TO CAUSE THE PREFERRED STOCK TO BE CONVERTED, IN WHOLE OR IN PART, ON A PRO
RATA  BASIS,  INTO  SHARES OF COMMON  STOCK ON 60 DAYS'  PRIOR  WRITTEN  NOTICE,
PROVIDED  THAT THE CLOSING BID QUOTATION FOR THE COMMON STOCK AS REPORTED ON THE
NASDAQ,  OR ON SUCH EXCHANGE ON WHICH THE COMMON STOCK IS THEN TRADED OR LISTED,
EXCEEDS 300% OF THE PREFERRED  CONVERSION PRICE FOR 20 CONSECUTIVE  TRADING DAYS
ENDING  THREE  DAYS  PRIOR TO THE DATE OF THE  NOTICE OF  MANDATORY  CONVERSION.
NOTWITHSTANDING  THE  FOREGOING,  THE COMPANY  SHALL NOT HAVE THE RIGHT TO FORCE
SUCH  MANDATORY  CONVERSION  AT ANY TIME ANY SHARES OF SERIES A PREFERRED  STOCK
REMAIN OUTSTANDING.

         MANDATORY REDEMPTION

IF THE COMPANY IS REQUIRED TO REPURCHASE,  REDEEM OR OTHERWISE ACQUIRE SHARES OF
SERIES A PREFERRED STOCK REPRESENTING MORE THAN 5% OF THE AGGREGATE STATED VALUE
OF THE SERIES A  PREFERRED  STOCK THEN THE COMPANY  SHALL  OFFER TO  REPURCHASE,
REDEEM OR OTHERWISE ACQUIRE THE SHARES OF PREFERRED STOCK, ON A PARI PASSU BASIS
WITH THE SERIES A PREFERRED STOCK BASED ON THE RELATIVE LIQUIDATION  PREFERENCES
OF EACH SUCH SERIES OF PREFERRED STOCK. THE COMPANY SHALL REPURCHASE,  REDEEM OR
OTHERWISE  ACQUIRE  THE SHARES OF  PREFERRED  STOCK WITH THE SAME  CONSIDERATION
WHICH IS PAID TO THE HOLDERS OF SERIES A PREFERRED STOCK.


                                       -8-


<PAGE>

                                                                       EXHIBIT B


         TERMS OF BRIDGE FINANCING AND SENIOR SECURED CONVERTIBLE NOTES

THE  FOLLOWING IS A SUMMARY OF THE PROPOSED  TERMS OF THE SALE OF  $3,000,000 OF
BRIDGE NOTES (AS DEFINED BELOW) AND BRIDGE  WARRANTS (AS DEFINED BELOW) OF GENTA
INCORPORATED, A DELAWARE CORPORATION (THE "COMPANY") PURSUANT TO A UNIT PURCHASE
AGREEMENT.


ISSUER:              GENTA INCORPORATED, A DELAWARE CORPORATION (THE "COMPANY").

ISSUE:              $3,000,000  AGGREGATE  FACE AMOUNT OF SENIOR  SECURED BRIDGE
                    NOTES  (THE   "BRIDGE   NOTES")  AND  AN  AGGREGATE  OF  (A)
                    [7,800,000]  WARRANTS (THE "CLASS A BRIDGE  WARRANTS") AT AN
                    EXERCISE PRICE OF $.001 AND (B)  [12,200,000]  WARRANTS (THE
                    "CLASS B BRIDGE  WARRANTS")  AN EXERCISE  PRICE EQUAL TO THE
                    LESSER OF THE AVERAGE  CLOSING BID PRICE OF THE COMMON STOCK
                    FOR  EITHER  (I)  THE  THIRTY   CONSECUTIVE   TRADING   DAYS
                    IMMEDIATELY  PRECEDING THE CLOSING OF THE SALE OF THE BRIDGE
                    NOTES  (THE  "BRIDGE  CLOSING  DATE"),   OR  (II)  THE  FIVE
                    CONSECUTIVE  TRADING DAYS  IMMEDIATELY  PRECEDING THE BRIDGE
                    CLOSING  DATE (THE CLASS A BRIDGE  WARRANTS  AND THE CLASS B
                    BRIDGE  WARRANTS  BEING  COLLECTIVELY  REFERRED  TO  AS  THE
                    "BRIDGE WARRANTS").


MINIMUM 
 SUBSCRIPTION
 AMOUNT PER 
 INVESTOR:          $500,000,  SUBJECT TO THE  COMPANY'S  RIGHT TO ACCEPT LESSER
                    AMOUNTS.


INTEREST ON THE
 BRIDGE NOTES:      THE BRIDGE NOTES WILL PAY INTEREST OF 1% PER MONTH. INTEREST
                    SHALL BE PAYABLE AT MATURITY OR UPON DEFAULT OR LIQUIDATION,
                    AS DESCRIBED BELOW. UPON CONVERSION,  ANY ACCRUED BUT UNPAID
                    INTEREST SHALL BE CONVERTED INTO SHARES OF PREFERRED STOCK.


MATURITY:           UNLESS SHAREHOLDER  APPROVAL IS OBTAINED EARLIER, THE BRIDGE
                    NOTES (AND ALL ACCRUED INTEREST THEREON) ARE DUE AND PAYABLE
                    ON THE  EARLIER  OF (I)  SIX (6)  MONTHS  AFTER  THE  BRIDGE
                    CLOSING DATE AND (II) FIVE (5) BUSINESS  DAYS  FOLLOWING THE
                    CLOSING OF THE  COMPLETION OF ANY EQUITY  OFFERING OR SERIES
                    OF  EQUITY  OFFERINGS  WITH  GROSS  PROCEEDS  IN  EXCESS  OF
                    $2,500,000 (A "QUALIFIED OFFERING").


SECURITY:           ON OR PRIOR TO THE BRIDGE  CLOSING  DATE,  THE COMPANY SHALL
                    ENTER  INTO A SECURITY  AGREEMENT  WITH A  COLLATERAL  AGENT
                    REASONABLY  ACCEPTABLE  TO THE PLACEMENT  AGENT  PURSUANT TO
                    WHICH THE  COMPANY  SHALL  GRANT THE  HOLDERS  OF THE BRIDGE
                    NOTES A FIRST LIEN SECURITY INTEREST IN ALL OF THE ASSETS OF
                    THE COMPANY  WHICH THE COMPANY IS NOT  OTHERWISE  RESTRICTED
                    FROM  GRANTING SUCH A SECURITY  INTEREST.  THE COMPANY SHALL
                    TAKE ALL STEPS  NECESSARY TO PERFECT SUCH SECURITY  INTEREST
                    AT THE TIME OF THE BRIDGE  CLOSING  DATE.  THE COMPANY  WILL
                    COVENANT NOT TO CREATE OR PERMIT THE IMPOSITION OF ANY LIENS
                    ON ANY OF ITS ASSETS FROM AND AFTER THE INITIAL CLOSING DATE
                    AND SHALL MAKE SUCH OTHER  REPRESENTATIONS,  WARRANTIES  AND
                    COVENANTS AS REQUESTED BY THE PLACEMENT AGENT.


CONVERSION
UPON SHAREHOLDER
 APPROVAL:          UPON  RECEIPT  OF  THE   REQUISITE   SHAREHOLDER   APPROVALS
                    NECESSARY   TO   CONSUMMATE   THE   OFFERINGS   AND  RELATED
                    TRANSACTIONS AS CONTEMPLATED BY THIS LETTER OF INTENT:

                    (A)  THE BRIDGE NOTES  TOGETHER  WITH THE ACCRUED AND UNPAID
                         INTEREST THEREON SHALL AUTOMATICALLY BECOME CONVERTIBLE
                         INTO PREFERRED STOCK AT AN INITIAL  CONVERSION PRICE OF
                         $5; AND


                                       -9-


<PAGE>

                    (B)  EACH  BRIDGE  WARRANT  SHALL  BE  CONVERTED  INTO A NEW
                         WARRANT (AS HEREINAFTER DEFINED).  "NEW WARRANTS" SHALL
                         MEAN A NEW  CLASS OF  WARRANTS  ENTITLING  THE  HOLDERS
                         THEREOF  TO  PURCHASE,  AT ANY  TIME  OVER A FIVE  YEAR
                         PERIOD ONE SHARE OF COMMON  STOCK AT AN EXERCISE  PRICE
                         EQUAL  TO THE  LESSER  OF (X)  $.15  OR (Y)  50% OF THE
                         AVERAGE  CLOSING  BID  PRICE OF THE  COMMON  STOCK  FOR
                         EITHER  (I)  THE  THIRTY   CONSECUTIVE   TRADING   DAYS
                         IMMEDIATELY SUCCEEDING THE DATE OF SHAREHOLDER APPROVAL
                         (THE  "APPROVAL  DATE")  OR (II) THE  FIVE  CONSECUTIVE
                         TRADING DAYS  IMMEDIATELY  PRECEDING  THE APPROVAL DATE
 
                         NOTWITHSTANDING   THE   FOREGOING,   THE  NEW  WARRANTS
                         EXERCISE  PRICE ARE SUBJECT TO AN  ADDITIONAL  ONE TIME
                         RESET ADJUSTMENT AT THE TIME OF THE FINAL CLOSING DATE,
                         IF THE EXERCISE  PRICE OF THE WARRANTS IS LESS THAN THE
                         EXERCISE  PRICE OF THE NEW WARRANTS.  IN SUCH EVENT THE
                         NEW WARRANTS EXERCISE PRICE SHALL BE REDUCED TO EQUAL A
                         50% DISCOUNT TO THE NEW WARRANTS EXERCISE PRICE.


DEFAULT/
 LIQUIDATION:       IN THE EVENT OF ANY DEFAULT (INCLUDING,  WITHOUT LIMITATION,
                    THE FAILURE OF THE  SHAREHOLDERS TO APPROVE THE TRANSACTIONS
                    CONTEMPLATED  BY THIS LETTER OF INTENT OR A  REQUIREMENT  TO
                    REDEEM,  REPURCHASE OR OTHERWISE  ACQUIRE SHARES OF SERIES A
                    PREFERRED STOCK), LIQUIDATION,  DISSOLUTION OR WINDING UP OF
                    THE COMPANY,  WHETHER VOLUNTARY OR INVOLUNTARY,  THE HOLDERS
                    OF  THE  BRIDGE  NOTES  WILL  BE  ENTITLED  TO  RECEIVE  THE
                    AGGREGATE  OUTSTANDING  PRINCIPAL AMOUNT OF SUCH BRIDGE NOTE
                    TOGETHER WITH THE ACCRUED AND UNPAID  INTEREST  THEREON.  IN
                    ADDITION,  UPON SUCH AN EVENT,  THE HOLDERS OF BRIDGE  NOTES
                    SHALL BE ABLE TO CONVERT  10% OF THEIR  NOTES INTO SHARES OF
                    COMMON STOCK AT A CONVERSION PRICE EQUAL TO $.001.


USE OF
 PROCEEDS:          THE COMPANY INTENDS TO USE THE NET PROCEEDS FROM THE SALE OF
                    THE BRIDGE NOTES TO BRIDGE ITS WORKING CAPITAL NEEDS THROUGH
                    SUCH  TIME  AS  IT  CAN   CONSUMMATE   AN  OFFERING  OF  ITS
                    SECURITIES.  THE COMPANY  COVENANTS  AND AGREES THAT IT WILL
                    NOT USE ANY OF THE PROCEEDS TO (I) REPAY ANY INDEBTEDNESS OF
                    THE COMPANY,  INCLUDING BUT NOT LIMITED TO ANY  INDEBTEDNESS
                    TO OFFICERS, EMPLOYEES,  DIRECTORS OR PRINCIPAL STOCKHOLDERS
                    OF THE COMPANY,  BUT EXCLUDING  ACCOUNTS PAYABLE INCURRED IN
                    THE ORDINARY COURSE OR (II) REDEEM,  REPURCHASE OR OTHERWISE
                    ACQUIRE ANY EQUITY SECURITY OF THE COMPANY.


REGISTRATION
 RIGHTS:            IN  THE  EVENT  THAT  A  QUALIFIED  OFFERING  HAS  NOT  BEEN
                    CONSUMMATED  BY THE DATE  WHICH IS 180 DAYS AFTER THE BRIDGE
                    CLOSING  DATE,  THE COMPANY  WILL  IMMEDIATELY  FILE A SHELF
                    REGISTRATION   STATEMENT  (THE   "REGISTRATION   STATEMENT")
                    COVERING THE RESALE OF THE SHARES OF COMMON STOCK UNDERLYING
                    THE PREFERRED STOCK  UNDERLYING THE BRIDGE NOTES, THE BRIDGE
                    WARRANTS  OR THE NEW  WARRANTS,  AS THE CASE MAY BE, AND USE
                    ITS BEST EFFORTS TO EFFECT THE REGISTRATION AND MAINTAIN THE
                    EFFECTIVENESS  OF  SUCH  REGISTRATION  STATEMENT  UNTIL  THE
                    COMPLETION OF THE DISTRIBUTION OF COMMON STOCK  CONTEMPLATED
                    THEREBY. IN THE EVENT THAT THE REGISTRATION STATEMENT IS NOT
                    EFFECTIVE  WITHIN  TWO  HUNDRED  AND TEN  (210)  DAYS OF THE
                    BRIDGE  CLOSING  DATE,  EACH  PURCHASER  OF THE BRIDGE NOTES
                    SHALL RECEIVE ADDITIONAL BRIDGE WARRANTS OR NEW WARRANTS, AS
                    THE CASE MAY BE, EQUAL TO 1.5% OF THE BRIDGE WARRANTS OR THE
                    NEW WARRANTS, AS THE CASE MAY BE, THEN HELD BY THEM FOR EACH
                    DAY  THEREAFTER  UNTIL THE  REGISTRATION  STATEMENT  BECOMES
                    EFFECTIVE.


                                      -10-


<PAGE>

TERMS OF THE 
 SENIOR SECURED 
 CONVERTIBLE 
 NOTES:             THE TERMS AND CONDITIONS OF THE SENIOR  SECURED  CONVERTIBLE
                    NOTES (THE  "NOTES")  SHALL BE  SUBSTANTIALLY  EQUIVALENT TO
                    THOSE  OF THE  BRIDGE  NOTES  EXCEPT  THAT  (I) THE  INITIAL
                    CONVERSION  PRICE  OF THE  NOTES  SHALL  BE  $10,  (II)  THE
                    MATURITY  SHALL BE 10 YEARS  FROM THE DATE OF  ISSUANCE  AND
                    (III) THE COMPANY SHALL HAVE THE RIGHT TO FORCE THE NOTES TO
                    BE CONVERTED  INTO  PREFERRED  STOCK AT ANYTIME AFTER ALL OF
                    THE  SHARES  OF SERIES A  PREFERRED  STOCK  SHALL  HAVE BEEN
                    CONVERTED  INTO COMMON STOCK OR OTHER  SECURITIES  JUNIOR TO
                    THE  PREFERRED  STOCK OR HAVE  OTHERWISE  BEEN  RETIRED IN A
                    MANNER  APPROVED  BY  HOLDERS  OF  66-2/3  OF THE  AGGREGATE
                    PRINCIPAL AMOUNT OF THE NOTES AND THE BRIDGE NOTES.




                              

                                      -11-

                                                                 Exhibit 10.11

                       AMENDMENT NO. 1 TO RIGHTS AGREEMENT


         THIS AMENDMENT NO. 1 (this "Amendment"),  dated as of January 28, 1997,
to the Rights Agreement, dated as of December 16, 1993 (the "Rights Agreement"),
between  Genta  Incorporated,   a  Delaware  corporation  (the  "Company"),  and
ChaseMellon  Shareholder  Services,  L.L.C.,  as  successor in interest to First
Interstate  Bank of California,  as Rights Agent (the "Rights  Agent"),  is made
with reference to the following facts:

         A. The Company and the Rights  Agent have  heretofore  entered into the
Rights Agreement.  Pursuant to Section 27 of the Rights  Agreement,  the Company
and the Rights  Agent  may,  from time to time,  supplement  or amend the Rights
Agreement in accordance with the provisions of such Section.

         B. The Board of Directors of the Company has  determined  that it is in
the best  interests  of the Company to enter into that  certain Note and Warrant
Purchase  Agreement,  dated as of January 28, 1997 (the  "Purchase  Agreement"),
between and among Aries Trust, a Cayman Islands Trust (the "Aries Trust"), Aries
Domestic Fund L.P., a limited  partnership  organized under the laws of Delaware
("Aries Domestic"), and the Company.

         C. As a condition to entering into the Purchase Agreement,  the Company
is  obligated  to amend the  Rights  Agreement  such that,  with  respect to the
execution  of and  the  consummation  of the  transactions  contemplated  by the
Purchase  Agreement,  neither  Aries  Trust,  Aries  Domestic,  nor any of their
affiliates  is  or  will  become  an  "Acquiring  Person"  and  that  no  "Stock
Acquisition  Date" or  "Distribution  Date" (as such  terms are  defined  in the
Rights Agreement) will occur.

         NOW,  THEREFORE,  in  consideration  of the  foregoing  and the  mutual
agreements set forth herein, the parties hereto agree as follows:

         1.       The definition of "Acquiring Person" set forth in
Section 1(a) of the Rights Agreement is hereby amended in its
entirety to read as follows:

                  (a) "Acquiring  Person" shall mean any Person (as such term is
         hereinafter  defined) who or which,  together with all  Affiliates  (as
         such  term is  hereinafter  defined)  and  Associates  (as such term is
         hereinafter  defined) of such Person, shall be the Beneficial Owner (as
         such term is  hereinafter  defined) of securities  representing  15% or
         more of the shares of Common Stock then  outstanding  or who was such a
         Beneficial Owner at any time after the date hereof, whether or not such
         Person continues to be the Beneficial Owner of securities  representing
         15% or more of the outstanding shares of Common Stock.  Notwithstanding
         the foregoing,


<PAGE>

                           (i) in no event shall a Person who or which, together
                  with all  Affiliates  and  Associates  of such Person,  is the
                  Beneficial Owner of less than 15% of the Company's outstanding
                  shares of Common Stock become an Acquiring  Person solely as a
                  result of a reduction  of the number of shares of  outstanding
                  Common Stock,  including  repurchases of outstanding shares of
                  Common Stock by the Company,  which  reduction  increases  the
                  percentage of outstanding  shares of Common Stock beneficially
                  owned by such Person (provided that any subsequent increase in
                  the amount of Common Stock  beneficially owned by such Person,
                  together with all  Affiliates  and  Associates of such Person,
                  without the prior  approval  of the  Company  shall cause such
                  Person to be an Acquiring Person);

                           (ii) the term Acquiring Person shall not mean (A) the
                  Company,  (B) any  subsidiary  of the Company (as such term is
                  hereinafter  defined),  (C) any  employee  benefit plan of the
                  Company or any of its  subsidiaries,  (D) any  entity  holding
                  securities of the Company organized,  appointed or established
                  by the Company or any of its  subsidiaries  for or pursuant to
                  the  terms  of any  such  plan or (E)  Aries  Trust,  a Cayman
                  Islands Trust (the "Aries Trust"), Aries Domestic Fund L.P., a
                  limited  partnership  organized  under  the  laws of  Delaware
                  ("Aries Domestic"), or any Affiliate or Associate thereof as a
                  result  of the  execution  of the  Note and  Warrant  Purchase
                  Agreement,  dated as of January  28,  1997,  between and among
                  Aries Trust,  Aries  Domestic  and the Company (the  "Purchase
                  Agreement") or as a result of the  consummation  of any of the
                  transactions contemplated by the Purchase Agreement; and

                           (iii) no Person  shall be  deemed to be an  Acquiring
                  Person if (A) within  five  business  days  after such  Person
                  would  otherwise have become an Acquiring  Person (but for the
                  operation  of this clause  (iii)),  such Person  notifies  the
                  Board of Directors that such Person did so  inadvertently  and
                  within two business days after such notification,  such Person
                  is the  Beneficial  Owner of less than 15% of the  outstanding
                  shares  of  Common  Stock or (B) by  reason  of such  Person's
                  Beneficial  Ownership of 15% or more of the outstanding shares
                  of  Common  Stock on the date  hereof  if prior to the  Record
                  Date,  such Person  notifies the Board of Directors  that such
                  Person is no longer the Beneficial Owner of 15% or more of the
                  then outstanding shares of Common Stock.

         2.       The first sentence of Section 3(a) of the Rights
Agreement is hereby amended by adding the following to the end
of such sentence:


                                      - 2 -


<PAGE>

                  ;  provided,  however,  that in no event shall a  Distribution
                     --------   -------
                  Date be deemed to occur as a result  of the  execution  of the
                  Purchase  Agreement or as a result of the  consummation of any
                  of the transactions contemplated by the Purchase Agreement.

         3. No "Stock  Acquisition  Date"  shall be  deemed  to occur  under the
Rights Agreement as a result of the execution of the Purchase  Agreement or as a
result  of the  consummation  of any of  the  transactions  contemplated  by the
Purchase Agreement.

         4.       All amendments made to the Rights Agreement in this Amendment 
shall be deemed to apply retroactively as well as prospectively.

         5. This Amendment shall be governed by and construed in accordance with
the laws of the State of Delaware and for all purposes  shall be governed by and
construed in accordance  with all laws of such State  applicable to contracts to
be made and performed entirely within such State.

         6.       This Amendment may be executed in counterparts, each of which 
shall be an original, but such counterparts shall together constitute one and 
the same instrument.


                                      - 3 -


<PAGE>

         IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed and attested, all as of the date and year first above written.


Attest:                                   GENTA INCORPORATED


By: /s/Courtney Stoner                    By: /s/Robert Wang
    ------------------                        --------------
Title:Financial Administrator             Title: Vice President


Attest:                                   CHASEMELLON SHAREHOLDER SERVICES
                                          L.L.C.

By:  /s/Ronald Lug                        By:  /s/Joseph Cammata
     -------------                             -----------------
Title:__________________                  Title: Assistant Vice President


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