GENTA INCORPORATED /DE/
SC 13D/A, 1998-12-03
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                              AMENDED SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 9)*

                               Genta Incorporated
                              --------------------
                                (Name of Issuer)

                     Common Stock, par value $.001 per share
                     ---------------------------------------
                         (Title of Class of Securities)

                                  372 45 M 20 7
                                  -------------
                                 (CUSIP Number)

                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                                 with a copy to:

Michael S. Weiss, Esq.                             Monica C. Lord, Esq.
Paramount Capital Asset                            Kramer Levin
   Management, Inc.                                  Naftalis & Frankel LLP
787 Seventh Avenue                                 919 Third Avenue
New York, NY 10019                                 New York, NY  10022
(212) 554-4372                                     (212) 715-9100


(Name, Address and Telephone Number of Person Authorized to Receive Notices and 
Communications)

                                November 23, 1998
                                -----------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following:
   | |

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule 13d- 1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                               Page 1 of 11 Pages




<PAGE>

<TABLE>
<CAPTION>
- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 2 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
<S>       <C>                                                                    <C>       <C>  

     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Paramount Capital Asset Management, Inc.
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     |_|

- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              | |
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware

- -----------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ----------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    17,492,707
                                     ----------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                     ----------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    17,492,707
- -----------------------------------------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              17,492,707
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              69.8% (46.1% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              CO
- -----------------------------------------------------------------------------------------------------------------
** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer.  As of November 23, 1998,  Paramount Capital
Asset Management,  Inc. may be deemed beneficially to own (within the meaning of
Rule 13d-3 under the  Securities  Exchange Act of 1934, as amended) 46.1% of the
aggregate  voting  power  of the  Common  Stock  and  Series D  Preferred  Stock
outstanding.




<PAGE>

- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 3 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Aries Domestic Fund, L.P.
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     |_|

- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              | |
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware

- -----------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ----------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    5,869,648
                                     ----------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                     ----------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    5,869,648
- -----------------------------------------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              5,869,648
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              39.9% (17.9% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              PN
- -----------------------------------------------------------------------------------------------------------------
** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer.  As of November 23, 1998, the Aries Domestic
Fund,  L.P. may be deemed  beneficially to own (within the meaning of Rule 13d-3
under the  Securities  Exchange Act of 1934, as amended)  17.9% of the aggregate
voting power of the Common Stock and Series D Preferred Stock outstanding.





<PAGE>

- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 4 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              The Aries Trust
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     |_|
- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              | |
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Cayman Islands

- -----------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ----------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    11,623,059
                                     ----------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                     ----------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    11,623,059
- -----------------------------------------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              11,623,059
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              59.3% (32.9% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON* OO (see Item 2)
- -----------------------------------------------------------------------------------------------------------------
** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer. As of November 23, 1998, The Aries Trust may
be deemed  beneficially  to own  (within  the  meaning of Rule  13d-3  under the
Securities Exchange Act of 1934, as amended) 32.9% of the aggregate voting power
of the Common Stock and Series D Preferred Stock outstanding.




<PAGE>

- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 5 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Lindsay A. Rosenwald, M.D.
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     |_|
- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              | |
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States

- -----------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            2,866,393 **
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ----------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    17,492,707
                                     ----------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    2,866,393**
                                     ----------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    17,492,707
- -----------------------------------------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              20,359,100**
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              72.9% (53.5% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              IN
- -----------------------------------------------------------------------------------------------------------------
** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of  stockholders  of the  Issuer.  As of  November  23,  1998,  Lindsay  A.
Rosenwald,  M.D. may be deemed  beneficially  to own (within the meaning of Rule
13d-3  under the  Securities  Exchange  Act of 1934,  as  amended)  53.5% of the
aggregate  voting  power  of the  Common  Stock  and  Series D  Preferred  Stock
outstanding.




<PAGE>

- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 6 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Hawkins Group, LLC
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     [x]
- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              | |
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States

- -----------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ----------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    526,737
                                     ----------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                     ----------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    526,737
- -----------------------------------------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              526,737
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              5.4% (1.8% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON* OO (See Item 2)
- -----------------------------------------------------------------------------------------------------------------

** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of  stockholders  of the Issuer.  As of November 23, 1998,  Mr.  Michael S.
Weiss may be deemed  beneficially to own (within the meaning of Rule 13d-3 under
the  Securities  Exchange Act of 1934, as amended) 1.8% of the aggregate  voting
power of the Common Stock and Series D Preferred Stock outstanding.




<PAGE>

- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 7 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Mr. Michael S. Weiss
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     [x]
- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              PF (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              | |
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States

- -----------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            148,327
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ----------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    526,737
                                     ----------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    148,327
                                     ----------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    526,737
- -----------------------------------------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              675,064
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              6.8%(2.2% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              IN
- -----------------------------------------------------------------------------------------------------------------

</TABLE>

** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of  stockholders  of the Issuer.  As of November 23, 1998,  Mr.  Michael S.
Weiss may be deemed  beneficially to own (within the meaning of Rule 13d-3 under
the  Securities  Exchange Act of 1934, as amended) 2.2% of the aggregate  voting
power of the Common Stock and Series D Preferred Stock outstanding.




<PAGE>

                                  SCHEDULE 13D

               This Amendment No. 9 amends and  supplements  the following items
of the Reporting Persons' Statement on Schedule 13D, dated February 24, 1997, as
amended to date (the "Schedule").

Item 3.        Source and Amount of Funds or Other Consideration

               The  information  contained  in Item 3 to the  Schedule is hereby
amended by adding the following:

               Between  November  1 and  November  22,  Aries  Trust  and  Aries
Domestic  purchased  197,200  and  68,500  shares  of Common  Stock  (additional
"Purchased  Common Stock"),  respectively,  on the open market.  Aries Trust and
Aries Domestic used their respective general funds for such purchases.

               Aries Trust made the following purchases:

Date                  No. of Shares                Sales Price
- ----                  -------------                -----------

11/02/98              15,500                       $0.960
11/03/98              15,500                       $0.969
11/04/98              15,600                       $0.969
11/05/98              15,600                       $0.906
11/06/98              15,500                       $0.906
11/09/98              13,600                       $0.906
11/10/98              13,600                       $0.960
11/11/98              13,600                       $0.969
11/12/98              13,600                       $0.969
11/13/98              13,600                       $1.000
11/16/98              16,600                       $1.000
11/17/98              16,500                       $0.997
11/18/98              16,600                       $1.000
11/19/98               1,800                       $1.000

               Aries Domestic made the following purchases:

Date                  No. of Shares                Sales Price
- ----                  -------------                -----------

11/02/98              5,500                        $0.960
11/03/98              5,500                        $0.969
11/04/98              5,400                        $0.969
11/05/98              5,400                        $0.906
11/06/98              5,500                        $0.906
11/09/98              4,700                        $0.906
11/10/98              4,700                        $0.960
11/11/98              4,700                        $0.969


                               Page 8 of 11 Pages

<PAGE>

11/12/98              4,700                        $0.969
11/13/98              4,700                        $1.000
11/16/98              5,700                        $1.000
11/17/98              5,800                        $0.997
11/18/98              5,700                        $1.000
11/19/98                500                        $1.000

         In  addition,  on November  23,  1998,  Aries Trust and Aries  Domestic
purchased an aggregate of 78,800 shares of Series A Preferred Stock in a private
placement.  Aries Trust used  $369,279.50 of its general funds to acquire 50,900
shares of Series A Preferred Stock, which are convertible into 369,287 shares of
Common  Stock,  and Aries  Domestic  used  $129,864.50  of its general  funds to
acquire 17,900 shares of Series A Preferred  Stock,  which are convertible  into
129,867 shares of Common Stock.

         The Filing  Persons  disclaim  beneficial  ownership  of all the Common
Stock  except the  Purchased  Common  Stock.  Mr.  Weiss,  Hawkins and the Aries
Reporting Persons each disclaim  beneficial  ownership of the securities held by
each other.

Item 5.        Interest in Securities of Issuer.

        The  information  contained in Item 5 to the Schedule is hereby  amended
and supplemented to read as follows:

               (a)  As  of  November  23,  1998:  Dr.  Rosenwald,  as  the  sole
                    shareholder  of  Paramount  Capital  and  as the  holder  of
                    Placement  Warrants  and  Advisory  Warrants,  may be deemed
                    beneficially  to  own  20,359,100  shares  or  72.9%  of the
                    Issuer's  Common  Stock;  Paramount  Capital,   through  the
                    acquisitions   of   securities  by  Aries  Trust  and  Aries
                    Domestic,  may be  deemed  beneficially  to  own  17,492,707
                    shares or 69.8% of the Issuer's Common Stock; and Mr. Weiss,
                    as  Managing   Member  of  Hawkins  and  as  the  holder  of
                    securities of the Issuer,  may be deemed to beneficially own
                    675,064 shares or 6.8% of the Issuer's  Common Stock.  Aries
                    Domestic, Aries Trust and Hawkins may be deemed beneficially
                    to own the following numbers of shares of Common Stock:

                    Aries Domestic                 5,869,648
                    Aries Trust                   11,623,059
                    Hawkins                          526,737

                    Pursuant  to Rule  13d-4  promulgated  under the  Securities
                    Exchange  Act  of  1934,  as  amended,  the  Filing  Persons
                    disclaim beneficial ownership of all the Common Stock except
                    the  Purchased   Common   Stock.   Pursuant  to  Rule  13d-4
                    promulgated  under the  Securities  Exchange Act of 1934, as
                    amended,  the Aries Reporting Persons, Mr. Weiss and Hawkins
                    each disclaim beneficial ownership of the securities held by
                    each other.


                               Page 9 of 11 Pages



<PAGE>

                    The  outstanding  shares of Series D Preferred  Stock of the
                    Issuer are  entitled  to vote  together  with the holders of
                    Common  Stock  on  all  matters   submitted  to  a  vote  of
                    stockholders  of the Issuer.  As of November 23,  1998,  Dr.
                    Rosenwald and Paramount  Capital may be deemed  beneficially
                    to  own   (within  the  meaning  of  Rule  13d-3  under  the
                    Securities  Exchange  Act of 1934,  as  amended)  53.5%  and
                    46.1%,  respectively,  of the aggregate  voting power of the
                    Common Stock and Series D Preferred Stock outstanding.

               (b)  Dr. Rosenwald and Paramount  Capital share the power to vote
                    or to  direct  the  vote and to  dispose  or to  direct  the
                    disposition  of those shares owned by each of Aries Domestic
                    and Aries Trust. Dr. Rosenwald has the sole power to vote or
                    to  direct  the  vote  and  to  dispose  or  to  direct  the
                    disposition of the shares underlying the Placement  Warrants
                    and  Advisory  Warrants  held by him.  Mr. Weiss and Hawkins
                    share the power to vote or to direct the vote and to dispose
                    or to direct the disposition of the shares owned by Hawkins.
                    Mr.  Weiss has the sole  power to vote or to direct the vote
                    and to dispose or to direct  the  disposition  of the shares
                    that he owns.

               (c)  Other than certain of the open market and private  placement
                    purchases of Common Stock  reported in Item 3, the Reporting
                    Persons have not engaged in any  transactions  in the Common
                    Stock of the Issuer in the past 60 days.

               (d)&(e)   Not applicable.



                               Page 10 of 11 Pages



<PAGE>

                                   SIGNATURES
                                   ----------

               After reasonable  inquiry and to the best knowledge and belief of
the undersigned,  the undersigned certify that the information set forth in this
statement is true, complete and correct.

<TABLE>
<CAPTION>
<S>                          <C>    

                                 PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  December 3, 1998
        New York, NY             By: /s/ Lindsay A. Rosenwald, M.D.
                                     -------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman

                                 ARIES DOMESTIC FUND, L.P.
                                     By: Paramount Capital Asset Management, Inc.
                                           General Partner

Dated:  December 3, 1998
        New York, NY             By: /s/ Lindsay A. Rosenwald, M.D.
                                     -------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman


                                 THE ARIES TRUST
                                     By: Paramount Capital Asset Management, Inc.
                                          Investment Manager

Dated:  December 3, 1998
        New York, NY             By: /s/ Lindsay A. Rosenwald, M.D.
                                     -------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman


Dated:  December 3, 1998
        New York, NY             /s/ Lindsay A. Rosenwald, M.D.
                                 -------------------------------
                                 Lindsay A. Rosenwald, M.D.

Dated:  December 3, 1998
        New York, NY             /s/ Mr. Michael S. Weiss
                                 -------------------------------
                                 Mr. Michael S. Weiss


                                 HAWKINS GROUP, LLC

Dated:  December 3, 1998
        New York, NY         By:  /s/ Mr. Michael S. Weiss
                                 -------------------------------
                                 Mr. Michael S. Weiss
                                 Managing member

</TABLE>

                               Page 11 of 11 Pages



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