GENTA INCORPORATED /DE/
DEF 14A, 1998-06-22
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934


Filed by the Registrant [x] 
Filed by a party other than the Registrant [ ] 
Check the appropriate box: 
[ ] Preliminary  Proxy Statement 
[ ] Confidential, for Use of the Commission Only (as permitted by 
    Rule 14a-6(e)(2))
[x] Definitive Proxy Statement 
[ ] Definitive  Additional Materials 
[ ] Soliciting Material Pursuant to ss. 240.a-11(c) or ss. 240.a-12

                               Genta Incorporated
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

                                       N/A
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[x]      No fee required

[ ]    Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
       1)    Title of each class of securities to which transaction applies:

             -----------------------------------------------------------------
       2)    Aggregate number of securities to which transaction applies:

             -----------------------------------------------------------------
       3)    Per  unit  price  or other  underlying  value  of  transaction
             computed  pursuant  to  Exchange  Act Rule 0-11 (set forth the
             amount on which the filing fee is calculated  and state how it
             was determined):

             -----------------------------------------------------------------
       4)    Proposed maximum aggregate value of transaction:

             -----------------------------------------------------------------
       5)   Total fee paid:

            -----------------------------------------------------------------

[ ]    Fee paid previously with preliminary materials.
[ ]    Check box if any part of the fee is offset as provided  by  Exchange  Act
       Rule  0-11(a)(2) and identify the filing for which the offsetting fee was
       paid previously.  Identify the previous filing by registration  statement
       number, or the Form or Schedule and the date of its filing.
       1)       Amount Previously Paid:

                ---------------------------------------------------------------
       2)       Form, Schedule or Registration Statement No.:

                ---------------------------------------------------------------
       3)       Filing Party:

                ---------------------------------------------------------------
       4)       Date Filed:

                ---------------------------------------------------------------

<PAGE>
                                      GENTA
                           3550 GENERAL ATOMICS COURT
                               SAN DIEGO, CA 92121
                                 (619) 455-2700

                                                                  June 22, 1998


Dear Stockholder:

        You are cordially  invited to attend the Annual Meeting of  Stockholders
which will be held on July 14,  1998,  at 11:00  a.m.  at the  Harborside  Hyatt
Conference Center & Hotel, 101 Harborside Drive, Boston, Massachusetts.

        Proposal  One would  permit the Company to  effectuate  a reverse  stock
split of the Company's  outstanding  Common Stock to the extent deemed necessary
by the  Board  of  Directors  to  permit  Genta to meet the  minimum  bid  price
requirement  necessary to allow  Genta's  Common  Stock to remain  listed on the
Nasdaq Stock Market, Inc., among other things.  FURTHERMORE,  UNLESS THE REVERSE
STOCK SPLIT PROPOSAL IS APPROVED, THE COMPANY MIGHT HAVE INSUFFICIENT AUTHORIZED
BUT UNISSUED  SHARES OF COMMON STOCK TO SATISFY THE CONVERSION INTO COMMON STOCK
OF ALL OUTSTANDING  SERIES D PREFERRED STOCK. YOUR VOTE IS THEREFORE  ESPECIALLY
IMPORTANT.

        The formal  notice of the Annual  Meeting and the Proxy  Statement  have
been made a part of this invitation.

        After reading the Proxy  Statement,  please mark, date, sign and return,
at an early date, the enclosed proxy in the prepaid envelope to ensure that your
shares will be  represented  at the meeting.  If you have any  questions or need
assistance  in voting your shares,  please call our proxy  solicitor,  MacKenzie
Partners, Inc., at (800) 322- 2885 or (212) 929-5500 (call collect).

        A copy of the  Company's  Form  10-K,  as  amended,  for the year  ended
December 31, 1997, is enclosed.

        The Board of Directors and Management  look forward to seeing you at the
meeting.


                                            Sincerely yours,


                                            /s/ Kenneth G. Kasses, Ph.D.
                                            ----------------------------
                                            Kenneth G. Kasses, Ph.D.
                                            President and
                                            Chief Executive Officer


<PAGE>

                               GENTA INCORPORATED

                    Notice of Annual Meeting of Stockholders
                            to be held July 14, 1998


               The Annual Meeting of  Stockholders  ("Annual  Meeting") of Genta
Incorporated  (the  "Company") will be held at the Harborside  Hyatt  Conference
Center & Hotel, 101 Harborside Drive, Boston,  Massachusetts on July 14, 1998 at
11:00 a.m., for the following purposes:


        1.      To  consider  and vote  upon  alternate  proposals  to amend the
                Company's Restated Certificate of Incorporation,  as amended, to
                effectuate a two for three,  one for two, two for five,  one for
                three,  one for four, one for five, one for seven or one for ten
                reverse stock split (if approved,  shares of outstanding  Common
                Stock will be converted into a lesser number of shares of Common
                Stock and the  conversion  ratios of the  outstanding  shares of
                Preferred Stock will be commensurately adjusted).

        2.      To  consider  and vote upon a  proposal  to amend the  Company's
                Restated Certificate of Incorporation, as amended, to remove the
                requirement that stockholder action be taken at a meeting.

        3.      To  consider  and vote upon a  proposal  to amend the  Company's
                Restated Certificate of Incorporation, as amended, to remove the
                classification of the Board of Directors.

        4.      To elect four Class I directors.

        5.      To adopt the 1998 Stock  Incentive Plan and to approve grants of
                options under such plan.

        6.      To adopt the Non-Employee  Directors' 1998 Stock Option Plan and
                to approve grants of options under such plan.

        7.      To transact such other  business as may properly come before the
                Annual Meeting and any adjournment of the Annual Meeting.

        The Executive Committee of the Board of Directors has fixed the close of
business on June 8, 1998 as the record  date for  determining  the  stockholders
entitled  to notice of and to vote at the  Annual  Meeting  and any  adjournment
thereof.  A complete list of stockholders  entitled to vote will be available at
the  Assistant  Secretary's  office,  3550  General  Atomics  Court,  San Diego,
California, during the ten days before the meeting.


June 22, 1998                              By Order of the Board of Directors,


                                                   /s/ Kenneth G. Kasses, Ph.D.
                                                   ----------------------------
                                                       Kenneth G. Kasses, Ph.D.
                                                       President and
                                                       Chief Executive Officer

        IT IS IMPORTANT THAT YOUR SHARES ARE  REPRESENTED AT THIS MEETING.  EVEN
IF YOU PLAN TO ATTEND IN PERSON, PLEASE PROMPTLY MARK, DATE, SIGN AND RETURN THE
ENCLOSED PROXY. THIS WILL NOT LIMIT YOUR RIGHT TO ATTEND OR VOTE AT THE MEETING.


<PAGE>

                               GENTA INCORPORATED
                           3550 GENERAL ATOMICS COURT
                           SAN DIEGO, CALIFORNIA 92121
                                 (619) 455-2700

                                ----------------

                                 PROXY STATEMENT
                                ----------------


        THIS PROXY STATEMENT IS FURNISHED IN CONNECTION WITH THE SOLICITATION BY
THE BOARD OF  DIRECTORS  OF GENTA  INCORPORATED,  A  DELAWARE  CORPORATION  (THE
"COMPANY"), OF PROXIES IN THE ACCOMPANYING FORM TO BE USED AT THE ANNUAL MEETING
OF STOCKHOLDERS TO BE HELD AT THE HARBORSIDE  HYATT  CONFERENCE  CENTER & HOTEL,
101 HARBORSIDE DRIVE,  BOSTON,  MASSACHUSETTS ON JULY 14, 1998 AT 11:00 A.M. AND
ANY ADJOURNMENT  THEREOF ("THE ANNUAL MEETING").  The shares  represented by the
proxies received in response to this  solicitation and not revoked will be voted
at the Annual Meeting. A proxy may be revoked at any time before it is exercised
by filing  with the  Secretary  of the  Company a written  revocation  or a duly
executed  proxy  bearing a later  date or by  voting  in  person  at the  Annual
Meeting.  On the matters coming before the Annual Meeting for which a choice has
been specified by a stockholder by means of the ballot on the proxy,  the shares
will be voted accordingly.  If no choice is specified,  the shares will be voted
FOR each proposal described in this Proxy Statement.

        Stockholders  of record  of the  Company's  Common  Stock  (the  "Common
Stock")  and the Series D  Convertible  Preferred  Stock  ("Series  D  Preferred
Stock")  at the  close of  business  on June 8,  1998 (the  "Record  Date")  are
entitled  to notice  of and to vote at the  Annual  Meeting.  As of the close of
business on the Record Date,  the Company had  5,752,116  shares of Common Stock
outstanding and entitled to vote. Each holder of Common Stock is entitled to one
vote for each share held as of the Record  Date.  As of the close of business on
the Record Date, the Company also had 226,995 shares of Series D Preferred Stock
outstanding  and entitled to vote.  The Series D Preferred  Stock is entitled to
vote together with the Common Stock on an as-converted  basis (each share of the
Series D Preferred Stock has the equivalent vote of approximately  105.96 shares
of Common  Stock.) In addition,  as of the close of business on the Record Date,
the Company  had 451,100  shares of Series A  Convertible  Preferred  Stock (the
"Series A Preferred  Stock")  outstanding  and  entitled to notice of the Annual
Meeting.  Holders of the Series A Preferred Stock,  however, are not entitled to
vote at the Annual Meeting.

        Approval of Proposal One will require the affirmative vote of a majority
of the  aggregate  voting  power of the shares of  outstanding  Common Stock and
Series D  Preferred  Stock,  voting  together  as a single  class.  Approval  of
Proposals Two and Three will require the  affirmative  vote of the holders of at
least sixty-six and two-thirds  percent of the aggregate  voting power of all of
the then outstanding shares of Common Stock and Series D Preferred Stock, voting
together as a single  class.  Approval of  Proposals  Five and Six and any other
matters  submitted for stockholder  approval at this Annual Meeting will require
the affirmative  vote of a majority of the aggregate  voting power of the shares
of Common Stock and Series D Preferred  Stock,  present in person or represented
by proxy and entitled to vote on each such matter,  voting  together as a single
class.  Directors are elected by a plurality vote of the aggregate  voting power
of the shares of Common Stock and Series D Preferred Stock, present in person or
represented  by proxy,  voting  together as a single class.  For the election of
directors,  votes may be cast in favor of or  withheld;  votes that are withheld
will be  excluded  entirely  from the vote and will have no effect.  Abstentions
with  respect to any other matter are treated as shares  present or  represented
and  entitled  to vote on that  matter and thus have the same effect as negative
votes.

        Abstentions and broker  non-votes are treated as shares that are present
and  entitled to vote for purposes of  determining  the presence or absence of a
quorum.  However,  broker  non-votes  will not be counted  for the  purposes  of
determining the number of votes cast with respect to the particular  proposal on
which the broker has expressly not voted.  Therefore,  broker non-votes will not
affect the determination as to whether the requisite  majority of votes cast has
been obtained with respect to a particular proposal.


                                      - 1 -


<PAGE>

        The entire expense of printing, preparing,  assembling and mailing proxy
materials  and the cost of soliciting  proxies will be borne by the Company.  In
addition to the  solicitation  of proxies by mail,  solicitation  may be made by
certain  directors,  officers  and other  employees  of the  Company by personal
interview,  telephone, telegram or facsimile. No additional compensation will be
paid to such  persons  for such  solicitation.  In  addition,  the  Company  has
retained MacKenzie Partners, Inc. ("MacKenzie") to assist in the solicitation of
proxies for an  estimated  cost not to exceed  $12,000,  plus  reimbursement  of
reasonable   out-of-pocket   expenses.   MacKenzie  will  solicit  proxies  from
individuals,   brokers,   banks,  nominees  and  other  institutional   holders.
Approximately  20  persons  will be  used by  MacKenzie  in  their  solicitation
efforts, which may be made by telephone, facsimile, telegram and in person.

        The  Company  will  reimburse  brokerage  firms  and  others  for  their
reasonable  expenses in forwarding  proxy materials to the beneficial  owners of
the Company's Common Stock, Series A and Series D Preferred Stock, and obtaining
voting  instructions  from beneficial  owners of the Company's  Common Stock and
Series D Preferred Stock.

        This Proxy Statement and the accompanying form of proxy, together with a
copy of the  Company's  Form 10-K, as amended,  for the year ended  December 31,
1997, are being mailed to stockholders on or about June 22, 1998.


                                    IMPORTANT

        PLEASE  MARK,  DATE AND SIGN THE  ENCLOSED  PROXY AND  RETURN IT AT YOUR
EARLIEST  CONVENIENCE IN THE ENCLOSED  POSTAGE-PREPAID  RETURN ENVELOPE SO THAT,
WHETHER  YOU INTEND TO BE PRESENT AT THE ANNUAL  MEETING OR NOT,  YOUR SHARES OF
COMMON STOCK OR SERIES D PREFERRED STOCK CAN BE VOTED.  THIS WILL NOT LIMIT YOUR
RIGHT TO ATTEND OR VOTE AT THE ANNUAL MEETING.


                                      - 2 -


<PAGE>

                                  PROPOSAL ONE

                     APPROVAL OF REVERSE STOCK SPLITS OF THE
                       COMPANY'S OUTSTANDING COMMON STOCK

        The  Company's  Board  of  Directors  has  unanimously   approved,   and
recommended  that the  stockholders  of the Company  approve,  amendments to the
Company's Restated Certificate of Incorporation, as amended (the "Certificate of
Incorporation"),  to effect a two for three,  one for two, two for five, one for
three,  one for four,  one for five, one for seven and one for ten reverse stock
split, respectively,  of the Company's outstanding Common Stock (each a "Reverse
Stock Split" and, collectively,  the "Reverse Stock Splits"). If approved by the
stockholders, a Reverse Stock Split may be effected, as described below.

        IF THE REVERSE  STOCK  SPLITS ARE  APPROVED BY THE  STOCKHOLDERS  OF THE
COMPANY AT THE ANNUAL MEETING,  A REVERSE STOCK SPLIT WILL BE EFFECTED ONLY UPON
A  DETERMINATION  BY THE BOARD OF DIRECTORS THAT A REVERSE STOCK SPLIT IS IN THE
BEST INTERESTS OF THE COMPANY AND THE STOCKHOLDERS.  IN CONNECTION WITH ANY SUCH
DETERMINATION  BY THE BOARD OF  DIRECTORS,  THE BOARD WILL ALSO  SELECT,  IN ITS
DISCRETION,  ONE OF THE REVERSE STOCK SPLITS BASED ON ITS  DETERMINATION  OF HOW
MANY SHARES OF COMMON STOCK ARE LIKELY TO BECOME  ISSUABLE  PURSUANT TO EXISTING
INSTRUMENTS AND AGREEMENTS,  ON ITS  DETERMINATION  OF WHICH REVERSE STOCK SPLIT
WOULD RESULT IN THE GREATEST MARKETABILITY AND LIQUIDITY OF THE COMMON STOCK, ON
PREVAILING MARKET  CONDITIONS,  ON THE LIKELY EFFECT OF SUCH REVERSE STOCK SPLIT
ON THE  MARKET  PRICE OF THE COMMON  STOCK AND ON OTHER  RELEVANT  FACTORS.  THE
REMAINING  ALTERNATIVE  REVERSE  STOCK  SPLITS  WOULD BE  ABANDONED BY THE BOARD
PURSUANT TO SECTION 242(C) OF THE DELAWARE GENERAL  CORPORATION LAW (THE "DGCL")
WITHOUT FURTHER ACTION BY THE STOCKHOLDERS OF THE COMPANY.

        Stockholders may approve or reject the Reverse Stock Splits in whole but
not in part.  If approved by the  stockholders  of the Company,  a Reverse Stock
Split would become effective on any date (the "Effective  Date") selected by the
Board  of  Directors  on or  prior  to the  Company's  next  Annual  Meeting  of
Stockholders.  If no Reverse Stock Split is effected by such date,  the Board of
Directors  will take action to abandon all of the Reverse Stock Splits  pursuant
to Section 242(c) of the DGCL. The  procedures for  consummation  of the Reverse
Stock Splits are set forth in Exhibit A hereto.

        The terms of the Company's outstanding warrants, options and convertible
preferred  stocks provide that, upon any Reverse Stock Split,  their  respective
exercise or conversion prices will be commensurately  adjusted and the number of
shares of Common Stock issuable upon exercise or conversion of such  instruments
immediately  following a Reverse  Stock Split will equal the number of shares of
Common Stock that the  respective  holders of such  instruments  would have held
following the Reverse Stock Split if they had exercised for, or converted  into,
Common Stock immediately prior to such Reverse Stock Split.

ADVANTAGES

        The Board  believes  that a  decrease  in the number of shares of Common
Stock outstanding without any material alteration of the proportionate  economic
interest in the Company represented by individual shareholdings may increase the
trading price of such shares to a price more  appropriate for a listed security,
although no  assurance  can be given that the market  price of the Common  Stock
will rise in  proportion to the  reduction in the number of  outstanding  shares
resulting  from any Reverse  Stock Split or at all or remain at such a price for
any significant period of time.

        The Nasdaq Stock Market,  Inc. ("Nasdaq") requires that listed companies
maintain a minimum bid price. See "Threat of Nasdaq  Delisting" below. The Board
of Directors  believes that such a delisting could adversely  affect the ability
of the Company to attract new investors.  In addition, the Company has submitted
applications to the Pacific  Exchange and the Boston Stock Exchange and plans to
submit an application to the  Philadelphia  Stock Exchange.  Such exchanges have
minimum  bid  price  per  share  (or in some  cases  closing  price  per  share)
requirements  for initial listing of $1.00 for the Pacific  Exchange,  $2.00 for
the Boston Stock Exchange and $3.00 for the Philadelphia  Stock Exchange.  These
Reverse Stock Split proposals are designed to establish a stock price


                                      - 3 -


<PAGE>

to meet the Nasdaq and Pacific Exchange  requirement and, if deemed advisable by
the Board of Directors,  the minimum price  requirement  of some or all of these
other stock exchanges.

        In addition,  the Certificate of Designations for the Series D Preferred
Stock  provides  that the  conversion  price of the Series D Preferred  Stock in
effect on June 29, 1998 (the "Reset Date") be adjusted and reset effective as of
the Reset Date if the average  closing bid price of the Common  Stock for the 20
consecutive  trading days  immediately  preceding the Reset Date (the  "12-month
Trading  Price") is less than 140% of the then  applicable  Conversion  Price (a
"Reset  Event").  The Company has provided the holders of the Series D Preferred
Stock with the opportunity to agree, conditioned on acceptance by a majority, to
extend  the Reset  Date to  January  29,  1999,  to waive  the SEC  registration
requirement,  coupled with removal of the "lock-up" provisions (which would have
prevented  the sale of up to 75% of their  securities  for a  nine-month  period
following  the  effectiveness  of the  Registration  Statement)  and to  receive
additional warrants ("Consent  Warrants") which, if all of the holders of Series
D Preferred Stock accepted,  would result in the issuance of additional warrants
to purchase,  at $0.94375 per share,  807,900 shares of Common Stock, subject to
certain antidilution adjustments, exercisable until June 29, 2002.

        Upon the  occurrence of a Reset Event,  the then  applicable  Conversion
Price  will be reduced to be equal to the  greater of (i) the  12-month  Trading
Price divided by 1.40 and (ii) 25% of the then applicable Conversion Price. Each
share of Series D Preferred Stock is presently  convertible  into  approximately
105.96 shares of Common Stock.  Upon the  occurrence of a Reset Event,  up to an
additional  approximately  85 million  shares of Common  Stock could be issuable
upon  conversion  of  Series D  Preferred  Stock  (including  shares of Series D
Preferred  Stock  issuable upon  exercise of Unit Purchase  Warrants (as defined
below)).  In the event there is a Reset  Event,  the Company may not have enough
authorized but unissued  shares of Common Stock to satisfy the conversion of all
outstanding shares of Series D Preferred Stock unless a sufficient Reverse Stock
Split is effected.

        The increase in the portion of authorized  shares that would be unissued
after a Reverse Stock Split (the "Increased  Available Portion of Shares") could
be used for any proper  corporate  purpose approved by the Board of Directors of
the Company.  The Increased Available Portion of Shares will provide the Company
with increased  flexibility to issue additional shares in connection with future
financings,  for employee benefit plans, in connection with  acquisitions by the
Company,  upon the  occurrence  of a Reset Event as described  in the  preceding
paragraph,  to issue Consent  Warrants and to satisfy any  requirement  to issue
Penalty  Warrants (as defined and described  under  "Capitalization"  below.) In
addition, a Reverse Stock Split would increase the per-share conversion price of
Series D Preferred  Stock,  rendering  fewer  shares  issuable  upon  conversion
thereof.  This further alleviates the possibility of there being an insufficient
number of shares of Common Stock available to satisfy the conversion  obligation
upon the occurrence of a Reset Event.

DISADVANTAGES

        Because a Reverse  Stock  Split will result in the  Increased  Available
Portion  of  Shares,  the  Reverse  Stock  Split may be  construed  as having an
anti-takeover effect, although neither the Board of Directors nor the management
of the Company views this  proposal in that  perspective.  However,  the Company
could use the Increased Available Portion of Shares to frustrate persons seeking
to effect a takeover or  otherwise  gain control of the Company by, for example,
privately  placing  shares  with  purchasers  who  might  side with the Board of
Directors  in opposing a hostile  takeover  bid. In  addition,  shares of Common
Stock may be issued in the event that the rights issued in  connection  with the
Company's  Stockholder  Rights Plan are exercised.  Shares of Common Stock could
also be issued to a holder that would thereafter have sufficient voting power to
assure that any proposal to amend or repeal the  Company's  Amended and Restated
Bylaws (the "Bylaws") or certain  provisions of the Certificate of Incorporation
would not receive the requisite vote. Such uses of the Common Stock could render
more difficult, or discourage,  an attempt to acquire control of the Company, if
such transaction were opposed by the Board of Directors.  Further, the Increased
Available  Portion  of  Shares  not  otherwise  required  to meet the  Company's
obligations  under  its  Certificate  of  Incorporation  could be  issued by the
Company, without further stockholder approval, which could result in dilution to
the holders of Common Stock.


                                      - 4 -


<PAGE>

CAPITALIZATION

        As of June 8, 1998, the Company had outstanding: (i) 5,752,116 shares of
Common  Stock;  (ii)  451,100  shares of Series A  Preferred  Stock  which  were
convertible into an aggregate of approximately  3,287,304 shares of Common Stock
at a  conversion  price of $8.27 per  share;  (iii)  226,995  shares of Series D
Preferred  Stock  which were  convertible  into an  aggregate  of  approximately
24,052,450  shares of Common Stock at a conversion  price of $0.94375 per share;
(iv) warrants  ("Series A Warrants")  to purchase an aggregate of  approximately
675,966  shares of Common  Stock at an  exercise  price of $9.32 per share;  (v)
warrants ("Class D Warrants") to purchase an aggregate of approximately  807,900
shares of Common Stock at an exercise price of $0.94375 per share; (vi) warrants
("Bridge Warrants") to purchase an aggregate of 6,357,616 shares of Common Stock
at an exercise  price of $0.471875 per share;  (vii)  warrants  ("Line of Credit
Warrants")  to  purchase an  aggregate  of 50,000  shares of Common  Stock at an
exercise price of $2.50 per share;  (viii)  warrants to purchase an aggregate of
95,768 shares of Common Stock at various  exercise prices between  approximately
$13 and $21 per share;  (ix) options to purchase an aggregate of 109,552  shares
of Common  Stock;  and (x) warrants  ("Unit  Purchase  Warrants") to purchase an
aggregate  of 40,395  shares of Series D  Preferred  Stock and  201,975  Class D
Warrants,  which in turn are respectively convertible into, and exercisable for,
an  aggregate of  4,482,240  shares of Common Stock at $0.94375 per share.  Such
exercise and conversion prices, and, in the case of warrants, numbers of shares,
are subject to adjustment  upon the occurrence of certain  events.  Furthermore,
upon a Reset  Event,  up to an  additional  approximately  85 million  shares of
Common Stock might be issuable upon  conversion of the Series D Preferred  Stock
(including  the Series D  Preferred  Stock  issuable  upon  exercise of the Unit
Purchase Warrants) as a result of the reduction in the conversion price thereof.
Pursuant to the Note and Warrant Purchase Agreement dated as of January 28, 1997
(the "Note and  Warrant  Purchase  Agreement")  between the  Company,  the Aries
Domestic  Fund,  L.P.  ("Aries  Domestic")  and The Aries Fund, a Cayman Islands
Trust ("Aries Trust" and,  together with Aries Domestic,  the "Aries Funds"),  a
number of additional Bridge Warrants  ("Penalty  Warrants") equal to 1.5% of the
number of Bridge  Warrants  then held by the Aries  Funds shall be issued to the
Aries  Funds  for each day  beyond 30 days  after  consummation  of a  Qualified
Offering (as defined in the Note and Warrant Purchase Agreement,  and which date
was June 30, 1997) that a shelf registration statement covering the Common Stock
underlying the securities  purchased  pursuant to the Note and Warrant  Purchase
Agreement is not filed with the Securities and Exchange  Commission  (the "SEC")
and for each day  beyond  210 days  after  the  closing  date of the  investment
contemplated  by the  Note  and  Warrant  Purchase  Agreement  that  such  shelf
registration  statement is not declared  effective by the SEC. The Company filed
such shelf  registration  statement with the SEC on September 9, 1997;  however,
the Company has to date been  unable to have such shelf  registration  statement
declared  effective by the SEC. As a result,  the Company  could be obligated to
issue  Penalty  Warrants to the Aries Funds.  The Aries Funds have not, to date,
requested  that the Company  issue such  Penalty  Warrants.  The Company and the
Aries Funds are currently  conducting  negotiations to determine whether, and to
what extent, Penalty Warrants will be issued.

THREAT OF NASDAQ DELISTING

        On various dates since  December 10, 1997,  the minimum bid price of the
Company's  Common  Stock has been less than  $1.00 per  share.  The rules of the
Nasdaq  SmallCap  Market  require  issuers to  maintain a minimum  bid price for
continued  inclusion  of $1.00 per share of listed  securities.  Pursuant to the
Nasdaq's Marketplace Rule 4310(c)(8)(B), a failure to meet the minimum bid price
requirement for continued inclusion shall be deemed to exist if the relevant bid
price  remains under $1.00 for a period of 30  consecutive  business  days.  The
Company believes that, if the Reverse Stock Splits are approved, it can continue
to meet these requirements;  however, there can be no assurance that approval of
the Reverse  Stock Splits will succeed in securing a bid price for the Company's
Common Stock of at least $1.00 per share,  that such minimum price, if achieved,
would be maintained for the requisite  period,  or that even if Nasdaq's minimum
bid price  requirement  were satisfied,  the Company's Common Stock would not be
delisted from the Nasdaq SmallCap Market for other reasons.

EXCHANGE OF STOCK CERTIFICATES

        If the Reverse Stock Splits are approved by the Company's  stockholders,
the Company will instruct its transfer agent to serve as its exchange agent (the
"Exchange  Agent") and to act for holders of Common  Stock in  implementing  the
exchange of their certificates.


                                      - 5 -


<PAGE>

        Commencing on the Effective Date of a Reverse Stock Split,  stockholders
will be notified  and  requested to surrender  their  certificates  representing
shares  of Common  Stock to the  Exchange  Agent in  exchange  for  certificates
representing  post-Reverse Stock Split Common Stock.  Shares of new Common Stock
will be issued in exchange for presently issued and outstanding shares of Common
Stock in the applicable  ratio selected by the Board of Directors.  Beginning on
the Effective Date, each certificate representing shares of the Company's Common
Stock will be deemed for all corporate  purposes to evidence ownership of shares
of post-Reverse Stock Split Common Stock.

TREATMENT OF FRACTIONAL SHARES

        No scrip or fractional  certificates will be issued in connection with a
Reverse  Stock Split.  Stockholders  who would  otherwise be entitled to receive
fractional  shares  because  they hold a number  of  shares of Common  Stock not
evenly  divisible  will be entitled,  upon  surrender  to the Exchange  Agent of
certificates representing such shares, to receive one additional share of Common
Stock in exchange  for any  fractional  share to which they would  otherwise  be
entitled.  If more than one certificate shall be surrendered at one time for the
account of the same  stockholder,  the number of full shares of Common  Stock to
which such  stockholder  shall be entitled shall be computed on the basis of the
aggregate number of shares  represented by the  certificates so surrendered.  In
the  event  that the  Company's  transfer  agent  determines  that a  holder  of
certificates has not tendered all his  certificates  for exchange,  the transfer
agent shall carry forward any fractional  share until all  certificates  of that
holder have been  presented for exchange  such that  rounding up for  fractional
shares to any one person  shall not  exceed one share.  As a result of a Reverse
Stock  Split,  stockholders  who now own "round  lots" may hold "odd lots" after
such  Reverse  Stock  Split  and,  as a  result,  may be  subject  to  increased
transaction costs on the sale of their Common Stock.

        Stockholders  are  encouraged  to surrender  their  certificates  to the
Exchange Agent for certificates  evidencing whole shares of the Common Stock due
them for fractional interests.

FEDERAL INCOME TAX CONSEQUENCES

        The Reverse Stock Splits should not result in the recognition of gain or
loss. The holding period of the shares of post-Reverse  Stock Split Common Stock
will  include the  stockholders'  respective  holding  periods for the shares of
pre-Reverse  Stock Split  Common Stock  exchanged  therefor,  provided  that the
shares of Common Stock were held as a capital  asset.  The adjusted basis of the
shares of post-Reverse Stock Split Common Stock will be the same as the adjusted
basis of the Common Stock exchanged therefor.

        Although not free from doubt, the above treatment should also apply with
respect to additional  shares  received for fractional  shares.  However,  it is
possible  that the  receipt  of  additional  shares  could be  wholly  or partly
taxable. Holders should consult with their own tax advisors.

NO DISSENTER'S RIGHTS

        Under Delaware law,  stockholders are not entitled to dissenter's rights
of appraisal with respect to the Reverse Stock Splits.

        THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL ONE.

Approval of Proposal One will require the affirmative  vote of a majority of the
aggregate  voting power of the shares of  outstanding  Common Stock and Series D
Preferred Stock, voting together as a single class.


                                      - 6 -


<PAGE>

                                  PROPOSAL TWO

             AMENDMENT TO THE CERTIFICATE OF INCORPORATION TO REMOVE
                       THE STOCKHOLDER MEETING REQUIREMENT

        The Board has determined that the Certificate of Incorporation should be
amended to  eliminate  the  requirement  that  stockholder  action be taken at a
meeting,   and  has  unanimously  voted  to  recommend  such  amendment  to  the
stockholders.  If the  proposed  amendment  is approved,  the  requirement  that
stockholder  action  be taken at a meeting  will be  eliminated  and any  future
action  that  currently  must be  taken  at an  annual  or  special  meeting  of
stockholders may be taken without a meeting,  without prior notice and without a
vote if a written  consent  setting forth the action is signed by the holders of
outstanding  stock having not less than the minimum number of votes necessary to
authorize  the action at a meeting at which all the shares  entitled  to vote on
the action were present and voted.

        Article XI of the  Certificate of  Incorporation  currently  provides as
follows:

               No action  required  or  permitted  to be taken at any  annual or
        special meeting of the  stockholders  may be taken without a meeting and
        the power of stockholders to consent in writing,  without a meeting,  to
        the taking of any action is specifically denied. Special meetings of the
        stockholders  of the  corporation  may be called only by the Chairman of
        the Board or the Chief  Executive  Officer  of the  corporation  or by a
        resolution adopted by the affirmative vote of a majority of the Board of
        Directors.

        If the proposed amendment is approved,  the first sentence of Article XI
of the Certificate of Incorporation would be deleted.

        Section 228 of the DGCL states that unless a  corporation's  certificate
of  incorporation  provides  otherwise,  any action required to be taken, or any
action that may be taken, at any annual or special meeting of stockholders,  may
be taken without a meeting, without prior notice and without a vote if a written
consent  setting  forth  the  action to be taken is  signed  by the  holders  of
outstanding  stock having not less than the minimum number of votes necessary to
authorize  the  action at a meeting  at which all the  shares  entitled  to vote
thereon were present and voted.  Article XI of the Certificate of  Incorporation
presently  provides  that  stockholders  of the  Company  may not take action by
written  consent,  but must take any actions at a duly called  annual or special
meeting.  The deletion of the  provisions  of Article XI of the  Certificate  of
Incorporation  relating to the requirement that stockholder action be taken at a
meeting is intended  to remove any express  provisions  therein  requiring  that
stockholder action be taken at a meeting. The procedures for consummation of the
removal  of the  stockholder  meeting  requirement  are set  forth in  Exhibit B
hereto.

        The Company believes that the delay and unnecessary  expense involved in
holding such meetings is unwarranted if the holders of sufficient votes to adopt
the  proposed  action are in favor of the  action.  The  Company  does intend to
continue to hold annual meetings of stockholders.  Accordingly,  the Company now
proposes to amend its  Certificate of  Incorporation  to permit  stockholders to
take action by written consent in lieu of a meeting.

        If Proposal Two is approved,  the Company will file a  certificate  with
the Secretary of State of the State of Delaware  reflecting  the deletion of the
first sentence of Article XI of the Certificate of Incorporation,  such deletion
to become effective on the filing thereof.  Furthermore,  the Board of Directors
will amend Section  Eleven of Article I of the Bylaws to remove the  requirement
that stockholder action be taken at a meeting from the Bylaws.


        THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL TWO.

Approval of Proposal Two will require the affirmative  vote of the holders of at
least sixty-six and two-thirds  percent of the aggregate  voting power of all of
the then outstanding shares of Common Stock and Series D Preferred Stock, voting
together as a single class.


                                      - 7 -


<PAGE>

                                 PROPOSAL THREE

           AMENDMENT TO THE CERTIFICATE OF INCORPORATION TO ELIMINATE
                  THE CLASSIFICATION OF THE BOARD OF DIRECTORS

        The Board has determined that the Certificate of Incorporation should be
amended to  eliminate  the  classification  of the Board and to provide  for the
annual election of all directors,  and has  unanimously  voted to recommend such
amendment  to the  stockholders.  If the proposed  amendment  is  approved,  the
classified Board will be eliminated, the current term of office of each director
will end at the Annual  Meeting in 1999 and all  directors  will  thereafter  be
elected for one-year terms at each annual meeting of stockholders.

        Pursuant to the Certificate of Incorporation,  the Board is divided into
three  classes with  staggered  three-year  terms and not more than one class of
directors  is elected  at any  annual  meeting  of  stockholders.  The  proposed
amendment to the Certificate of Incorporation  would eliminate the three classes
with their staggered  three-year  terms, as described below, and provide for the
annual election of all directors.

        Proponents of classified  boards of directors  believe that a classified
board helps the board of directors  maintain a greater  continuity of experience
because the majority of directors  at any given time will have  experience  with
the business  affairs and operations of the company.  This continuity may assist
the company in long-term strategic planning. Additionally, proponents argue that
a  classified  board  reduces  the  possibility  of a sudden  change in majority
control of the board of directors; in the event of a hostile takeover attempt, a
classified  board may  encourage  a person  seeking  control  of the  company to
initiate  arm's-length  discussions  with management and the board, who are in a
position to negotiate a more favorable transaction for stockholders.

        However,  the Board believes that a classified board of directors limits
the ability of stockholders  to elect  directors and to exercise  influence over
the Company.  Therefore,  the Board  believes that it is in the best interest of
the Company and its  stockholders to eliminate the classified Board of Directors
thereby permitting the Company's  stockholders to elect all members of the Board
of Directors annually. The Board further believes that this will promote greater
accountability of each director to all stockholders and will allow the Company's
stockholders  an opportunity  annually to register their views on the collective
performance  of the Board of  Directors  and the  performance  of each  director
individually.  In addition, the Board believes that the Company should no longer
retain the current Board structure because of the negative perception among many
potential investors and investor groups concerning staggered boards in general.

        Article X of the  Certificate  of  Incorporation  currently  provides as
follows:

               The Board of  Directors  shall be  divided  into  three  classes,
        designated Class I, Class II and Class III, as nearly equal in number as
        possible,  and the term of office of directors of one class shall expire
        at each  annual  meeting  of  stockholders,  and in all cases as to each
        director  until such  director's  successor  shall be elected  and shall
        qualify or until  such  director's  earlier  resignation,  removal  from
        office, death or incapacity.  Additional directorships resulting from an
        increase in number of directors  shall be apportioned  among the classes
        as equally as possible. The initial term of office of directors of Class
        I shall expire at the annual meeting of  stockholders  in 1995;  that of
        Class II shall expire at the annual  meeting in 1996;  and that of Class
        III shall expire at the annual  meeting in 1997;  and in all cases as to
        each director until such director's successor shall be elected and shall
        qualify or until  such  director's  earlier  resignation,  removal  from
        office, death or incapacity.  At each annual meeting of stockholders the
        number of directors  equal to the number of directors of the class whose
        term  expires at the time of such  meeting  (or, if less,  the number of
        directors  properly  nominated  and  qualified  for  election)  shall be
        elected to hold  office  until the third  succeeding  annual  meeting of
        stockholders after their election.

        If the proposed  amendment is approved,  Article X of the Certificate of
Incorporation would be deleted and replaced with the following:


                                      - 8 -


<PAGE>

               The number of directors which shall constitute the whole Board of
        Directors  of the  corporation  shall be  determined  in the  by-laws as
        provided  therein.  The directors of the corporation shall be elected by
        the  stockholders  entitled to vote  thereon at each  annual  meeting of
        stockholders  and shall hold  office  until the next  annual  meeting of
        stockholders  and until  their  respective  successors  shall  have been
        elected and qualified,  subject,  however, to prior death,  resignation,
        retirement,  disqualification or removal from office. The term of office
        of each  director in office on July 14, 1998 shall expire at the time of
        the  opening  of the polls for the  election  of  directors  at the next
        annual meeting of stockholders of the corporation.

        Section  141(d) of the DGCL  requires  that a  corporation  desiring  to
classify its board of directors must expressly  provide for such  classification
in either its certificate of incorporation  or its by-laws.  The deletion of the
provisions of Article X relating to the  classification of the Board is intended
to remove any express  provision for the  classification  of the Board,  thereby
removing the  classification  of the Board. If the classified Board of Directors
is  eliminated,  Delaware law provides that any director or the entire Board may
be removed, with or without cause, by the holders of a majority of the shares of
the Company entitled to vote for the election of directors.

        If Proposal Three is approved,  the Company will file a certificate with
the Secretary of State of the State of Delaware reflecting the changes resulting
from the  amendment,  such changes to become  effective  on the filing  thereof.
Thereafter,  the terms of the directors currently serving in Class I whose terms
would otherwise  expire at the 2001 Annual Meeting of Stockholders and the terms
of directors serving in Class III whose terms would otherwise expire at the 2000
Annual Meeting of Stockholders  will have their terms as directors expire at the
1999  Annual  Meeting  of  Stockholders.  All  current  members  of the Board of
Directors  and all current  nominees for director  have agreed to shorten  their
terms  as  directors  to  expire  at the  date of the  next  Annual  Meeting  of
Stockholders.  Accordingly,  if Proposal Three is approved,  commencing with the
next  Annual  Meeting of  Stockholders,  the entire  Board of  Directors  of the
Company  will be  elected  annually.  The  procedures  for  consummation  of the
declassification of the Board of Directors are set forth in Exhibit C hereto.

        The proposal to eliminate the  classification  of the Board of Directors
is neither the result of any effort to unseat incumbent  directors,  nor, to the
knowledge of the Board of Directors, any effort by any person to take control of
the Board.

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL THREE.

Approval of Proposal Three will require the  affirmative  vote of the holders of
at least sixty-six and two-thirds  percent of the aggregate  voting power of all
of the then  outstanding  shares of Common  Stock and Series D Preferred  Stock,
voting together as a single class.


                                      - 9 -


<PAGE>

                                  PROPOSAL FOUR

                          ELECTION OF CLASS I DIRECTORS


        The  Company has three  classes of  directors  (each a "Class")  serving
staggered  three-year terms.  Each Class consists of four directors.  Currently,
there is one director vacancy in Class II and one director vacancy in Class III.
If Proposal Three is approved by the stockholders, four Class I directors are to
be elected at the Annual  Meeting  for a term of one year  expiring  at the next
Annual Meeting or until such directors'  successors  shall have been elected and
qualified,  and the other directors of the Company will continue in office until
the next Annual Meeting.  If Proposal Three is not approved by the stockholders,
four Class I  directors  are to be elected at the Annual  Meeting  for a term of
three  years  expiring  at the Annual  Meeting in 2001 or until such  directors'
successors shall have been elected and qualified, and the other directors of the
Company will continue in office for their existing  terms,  which expire in 1999
and 2000 for Class II and Class III directors, respectively.

        Unless authority to vote for directors is withheld,  the Company intends
that the shares represented by the enclosed proxy will be voted for the election
of Kenneth G. Kasses, Ph.D., Peter Salomon, M.D., Andrew J. Stein, and Harlan J.
Wakoff,  who are currently  members of the Board of Directors of the Company and
Class I  Directors.  In the event such  nominees  become  unable or unwilling to
accept nomination or election, the shares represented by the enclosed proxy will
be voted for the election of such persons as the Board of Directors  may select.
The Board of Directors  has no reason to believe that any of such  nominees will
be unable or unwilling to serve.

        Set forth below is certain information regarding the Company's directors
and  executive  officers,  including  information  furnished by them as to their
principal  occupations and business experience for the past five years,  certain
directorships  held by each,  their  respective  ages as of June 8, 1998 and the
year in which each became a director of the  Company.  Each  director has served
continuously with the Company since his first election as indicated below.

                                    DIRECTORS

        Name                                                               Age

        CLASS I

Kenneth G. Kasses, Ph.D./1/.................................................53
Peter Salomon, M.D..........................................................38
Andrew J. Stein/2/..........................................................53
Harlan J. Wakoff/3/.........................................................31

        CLASS II

Glenn L. Cooper, M.D./1/, /2/...............................................45
Lawrence J. Kessel, M.D./3/.................................................44
Bobby W. Sandage, Jr., Ph.D./3/.............................................44

        CLASS III

Donald G. Drapkin/1/........................................................50
Michael S. Weiss/1/,/2/.....................................................32
Robert E. Klem, Ph.D........................................................52

/1/ Member of the  Company's  Executive  Committee  formed by  resolution of the
Board of Directors on January 29, 1998.

/2/ Member of the Company's  Compensation  Committee formed by resolution of the
Board of Directors on January 29, 1998.

/3/ Member of the Company's Audit Committee formed by resolution of the Board of
Directors on January 29, 1998.


                                     - 10 -


<PAGE>


        Kenneth G. Kasses, Ph.D., has been Genta's President and Chief Executive
Officer  since  October  1997  and a member  of the  Board  of  Directors  since
September   1997.   From   1991-1997,   Dr.  Kasses  was  affiliated   with  the
Radiopharmaceutical Division of The Dupont Merck Pharmaceutical Company, serving
as Senior Vice  President  and General  Manager until 1994 when he was appointed
President.  From 1988 through 1990, he served as Director,  Business Development
and Planning,  for the Medical  Products  Department of E.I. DuPont de Nemours &
Company,  Inc.  In that  capacity he played a key role in the  formation  of The
Dupont Merck  Pharmaceutical  Company,  a joint venture between DuPont and Merck
and Co., Inc.  Prior to that he served as Director,  U.S.  Pharmaceuticals,  for
DuPont from 1987-1988 and as President of DuPont  Critical Care from  1986-1987.
Prior to this,  Dr. Kasses held a variety of executive  positions from 1973-1986
at American Critical Care, CIBA-GEIGY  Pharmaceuticals,  Ayerst Laboratories and
Block Drug Company. Dr. Kasses received a B.S. in biology from Dickinson College
in 1966 and a Ph.D. in pharmacology from New York Medical College in 1974.

        Peter  Salomon,  M.D.,  FACG,  has been a member of the  Genta  Board of
Directors since September  1997. His principal  employment  during the last five
years has been as a Board Certified  Gastroenterologist  in private  practice in
Boca Raton and Delray Beach, Florida with Gastroenterology  Consultants of South
Florida. In addition, he is an expert consultant for several insurance companies
and law firms in the areas of gastroenterology  and liver diseases.  Dr. Salomon
graduated  magna cum laude from New York  University  in 1981.  He received  his
Medical Degree from New York University in 1985.  Following this he received his
training in Internal Medicine and  Gastroenterology  at The Mount Sinai Hospital
in New York where he also held a grant from the Crohn's  and Colitis  Foundation
to perform  research in  inflammatory  bowel  disease.  He was also  selected to
receive  advanced  training  in  therapeutic  endoscopic  techniques  at  Aarhus
Kommunehospital  in Aarhus,  Denmark.  He has been elected to the Phi Beta Kappa
society and is a member of MENSA. He has done extensive research in the field of
gastroimmunology  and has  published  numerous  articles  and book  chapters  in
various  leading  scientific  journals  and  textbooks.  He is also  currently a
director of PolaRx, a privately-held biotechnology firm.

        Andrew J. Stein has been a member of the Genta Board of Directors  since
September  1997.  In addition,  he is President  of Benake  Corporation,  Equity
Partner  in  Metromedia  Asia and a member  of the  Board of  Directors  of News
Communications.  Mr. Stein is also a member of the New York State  Commission of
Privatization and the New York State Research Council on  Privatization.  He was
the  Chairman of the  Commission  for the Study of Youth Crime and  Violence and
Reform of the Juvenile  Justice System from 1993-1995.  From 1986 to 1993 he was
President of the Council,  New York City.  From 1978 to 1985 he was President of
the Borough of  Manhattan  and from 1969 to 1977 he was a member of the New York
State  Assembly,  where he served on the Health  Committee  and was appointed by
Gov.  Nelson  Rockefeller  as Chairman of the Commission on Living Costs and the
Economy, which reformed the nursing home industry in New York State. He was also
Chairman  of  the  New  York  City   Commission   on  Public   Information   and
Communication,  and has been a Trustee of the New York City Employees Retirement
System and an ex officio  member of The Museum of The City of New York,  The New
York  Public  Library,  The  Metropolitan  Museum of Art and The Queens  Borough
Public Library.

        Harlan J. Wakoff has been a member of the Genta Board of Directors since
September  1997. He is also the Chairman of the Company's Audit  Committee.  Mr.
Wakoff  has been a Vice  President  of the  Media and  Entertainment  Investment
Banking  Group  at  Furman  Selz  L.L.C.  since  June  1996.  He was  previously
affiliated  with the investment  banking groups at NatWest  Markets from January
1995 to June 1996 and Kidder Peabody & Co. from August 1993 to January 1995. Mr.
Wakoff  received  an  M.B.A.  from  The  Wharton  School  at the  University  of
Pennsylvania  in May 1993 and a B.S. in  accounting,  summa cum laude,  from the
State University of New York at Albany.

        Glenn L. Cooper, M.D., has been a member of the Genta Board of Directors
since  September  1997.  He is also the Chairman of the  Company's  Compensation
Committee. He has also been President, Chief Executive Officer and a director of
Interneuron  Pharmaceuticals,  Inc. since May 1993.  From September 1992 to June
1994 Dr.  Cooper was  President,  Chief  Executive  Officer  and a  director  of
Progenitor, Inc. and is currently Chairman at Progenitor. He is also Chairman of
Intercardia, Inc., Chairman and Acting President of Transcell Technologies, Inc.
and  a  director  of  InterNutria,  Inc.,  all  of  which  are  subsidiaries  of
Interneuron.   In  addition,   Dr.   Cooper  serves  as  a  director  of  Aeolus
Pharmaceuticals,  Inc., a subsidiary of  Intercardia.  Dr. Cooper also served as
President and Chief Executive  Officer of Intercardia from March 1994 to January
1995. Prior to joining Progenitor, Dr. Cooper


                                     - 11 -


<PAGE>

was   Executive   Vice   President  and  Chief   Operating   Officer  of  Sphinx
Pharmaceuticals  Corporation  since August 1990. Dr. Cooper had been  associated
with Eli Lilly  since  1985,  most  recently,  from June 1987 to July  1990,  as
Director,  Clinical  Research,  Europe,  of Lilly Research Center Limited;  from
October  1986  to May  1987  as  International  Medical  Advisor,  International
Research  Coordination  of Lilly  Research  Laboratories;  and from June 1985 to
September 1986 as Medical Advisor, Regulatory Affairs,  Chemotherapy Division at
Lilly Research Laboratories.  Dr. Cooper received his M.D. from Tufts University
School of Medicine, performed his postdoctoral training in Internal Medicine and
Infectious  Diseases at the New England  Deaconess  Hospital  and  Massachusetts
General Hospital and is a magna cum laude graduate of Harvard College.

        Lawrence J.  Kessel,  M.D.,  FACP,  CMD,  has been a member of the Genta
Board of Directors  since  September  1997. Dr. Kessel is a physician in private
practice in Philadelphia and a diplomate in both internal medicine and geriatric
medicine,  as well as a Fellow  of the  American  College  of  Physicians  and a
Certified  Medical  Director of  Long-Term  Nursing  Facilities.  Dr.  Kessel is
affiliated  with  Chestnut  Hill  Hospital,  Roxborough  Memorial  Hospital  and
Chestnut  Hill  Rehabilitation  Hospital and serves as a clinical  instructor at
Jefferson  Medical College.  He is also a medical director at Integrated  Health
Services  (IHS) and a staff  physician at Fairview  Paper Mill,  Green Acres Ivy
Hill  and  St.  Joseph's  Villa.   Dr.  Kessel  is  a  director  of  PolaRx,   a
privately-held biotechnology company.

        Bobby W. Sandage,  Jr.,  Ph.D.,  has been a member of the Genta Board of
Directors since September 1997. Dr. Sandage joined Interneuron  Pharmaceuticals,
Inc. in November 1991 as Vice President,  Medical and Scientific Affairs.  Since
December 1995 he has been Executive Vice President, Research and Development and
Chief Scientific Officer of Interneuron.  From February 1989 to November 1991 he
held  management  positions  in  the  Cardiovascular  Research  and  Development
division of The DuPont Merck Pharmaceutical  Company.  From May 1985 to February
1989 he was affiliated with the Medical  Department of DuPont Critical Care. Dr.
Sandage  is an  adjunct  professor  in the  Department  of  Pharmacology  at the
Massachusetts  College of Pharmacy.  Dr. Sandage  received his Ph.D. in Clinical
Pharmacy from Purdue  University and his B.S. in Pharmacy from the University of
Arkansas.  Dr.  Sandage  is  a  director  of  Aeolus  Pharmaceuticals,  Inc.,  a
subsidiary of Intercardia, Inc.

        Donald G.  Drapkin has been  Chairman  of the Genta  Board of  Directors
since  September  1997.  He is also  the  Chairman  of the  Company's  Executive
Committee.  Mr.  Drapkin has been a director and Vice  Chairman of  MacAndrews &
Forbes  Holdings,  Inc. and various of its affiliates since March 1987. Prior to
joining  MacAndrews  & Forbes,  Mr.  Drapkin  was a  partner  in the law firm of
Skadden,  Arps, Meagher & Flom in New York for more than five years. Mr. Drapkin
also is a director of the following  corporations which file reports pursuant to
the  Securities  Exchange  Act  of  1934:  Algos   Pharmaceutical   Corporation,
Anthracite Capital, Inc., BlackRock Asset Investors, Cardio Technologies,  Inc.,
The Cosmetic Center,  Inc.,  Playboy  Enterprises,  Inc.,  Revlon,  Inc., Revlon
Consumer Products  Corporation,  VIMRx Pharmaceuticals Inc. and Weider Nutrition
International.

        Michael S. Weiss has been Vice  Chairman of the Genta Board of Directors
since  September  1997 and was the Interim  Chairman  from May 1997 to September
1997.  Mr. Weiss is currently  Senior  Managing  Director of Paramount  Capital,
Inc., an investment  banking firm, and serves in a similar  capacity for certain
affiliated  entities.  He joined the companies in 1993. Prior to that, Mr. Weiss
was an attorney with Cravath, Swaine & Moore. Mr. Weiss also serves on the Board
of Directors of Pacific Pharmaceuticals,  Inc., Palatin Technologies, Inc., AVAX
Technologies,  Inc.,  as  Secretary  of Atlantic  Pharmaceuticals,  Inc.  and as
Chairman  of the  Board  of  Procept  Inc.,  all  publicly-traded  biotechnology
companies.  Additionally,  Mr.  Weiss is a member of the board of  directors  of
several privately-held  biopharmaceutical companies. Mr. Weiss received his J.D.
from  Columbia  University  School of Law and a B.S.  in Finance  from the State
University of New York at Albany.

        Robert E. Klem, Ph.D., has been a member of the Genta Board of Directors
since  February  1991, a Vice President of the Company since October 1991 and is
currently the Company's  Principal  Accounting  Officer and Principal  Financial
Officer.  Dr. Klem  co-founded  JBL  Scientific,  Inc.  ("JBL"),  a wholly-owned
subsidiary  of the Company,  in 1973 and,  since then,  has been Chairman of the
Board and Chief  Technical  Officer  of JBL with  responsibility  for  research,
development and marketing activities. Previously, Dr. Klem was the Plant Manager
for E.I.  DuPont in  Victoria,  Texas from 1970 to 1974.  Dr. Klem  received his
Ph.D. in Organic Chemistry from the University of California at Riverside.


                                           - 12 -


<PAGE>


                               EXECUTIVE OFFICERS

        Name                                                                 Age


Lauren R. Brown, Ph.D.........................................................56
Kenneth G. Kasses, Ph.D.......................................................53
Robert E. Klem, Ph.D. ........................................................52

        Lauren R. Brown,  Ph.D.,  has been Vice  President of the Company  since
October  1991. He  co-founded  JBL in 1973 and since then has been  President of
JBL. Dr. Brown  received his Ph.D. in Organic  Chemistry  from the University of
California  at Riverside.  He is active in community  affairs in San Luis Obispo
and  presently  serves on the board of  directors of the YMCA and the Chamber of
Commerce.


        David Hale resigned as a Class III director  effective January 28, 1997.
On May 5, 1997,  Thomas Adams  resigned as a Class I director.  On September 11,
1997,  Sharon B.  Webster  resigned  as a Class I  director  and Paul O.P.  Ts'o
resigned as a Class II director.

        The Board of Directors  held 17 meetings  during the year ended December
31,  1997.  All  directors  attended  at least  75% of the  aggregate  number of
meetings of the Board of Directors, except that Dr. Cooper did not attend one of
the two meetings held during the time he served as a director. Directors receive
no fees for their services,  but  non-employee  directors are eligible for stock
options granted in consideration  for their service as directors.  See Proposals
Five and Six below.

        THE BOARD OF  DIRECTORS  UNANIMOUSLY  RECOMMENDS  A VOTE FOR EACH OF THE
CLASS I NOMINEES FOR DIRECTOR LISTED ABOVE.

Directors are elected by a plurality  vote of the aggregate  voting power of the
shares of  outstanding  Common  Stock and Series D Preferred  Stock,  present in
person or represented by proxy, voting together as a single class.


                                     - 13 -


<PAGE>

           STOCK OWNERSHIP OF MANAGEMENT AND CERTAIN BENEFICIAL OWNERS

        The  following  table sets forth  information  as of April 1, 1998 as to
shares of Common Stock beneficially owned by (i) the Company's  directors,  (ii)
the Company's  executive  officers named in the Summary  Compensation  Table set
forth herein,  (iii) the  directors  and executive  officers of the Company as a
group and (iv) each person  known by the Company to be the  beneficial  owner of
more than five  percent of the  outstanding  shares of the  Common  Stock of the
Company.  As of April 1,  1998,  each  share of  Series A  Preferred  Stock  was
convertible at the option of the holder into approximately 7.26 shares of Common
Stock and each share of Series D Preferred  Stock was  convertible at the option
of the  holder  into  approximately  105.96  shares of Common  Stock.  Except as
required by law or with respect to the  creation or amendment of senior  classes
of preferred  stock or creation of different  series or classes of Common Stock,
and in certain other  instances,  the holders of Series A Preferred Stock do not
have voting rights until  conversion into Common Stock.  The conversion price of
the  Series A and the  Series D  Preferred  Stock and the  numbers  of shares of
Common Stock  issuable  upon  conversion  thereof may be adjusted in the future,
based on the provisions in the Certificate of Incorporation.


<TABLE>
<CAPTION>
                                          COMMON STOCK               SERIES D PREFERRED STOCK
                                          ------------               ------------------------

NAME AND ADDRESS OF BENEFICIAL  AMOUNT AND NATURE OF   PERCENT OF   AMOUNT AND NATURE OF   PERCENT
OWNER                          BENEFICIAL OWNERSHIP(1)   CLASS    BENEFICIAL OWNERSHIP(1) OF CLASS

<S>                              <C>                    <C>            <C>                 <C>  
Lindsay A. Rosenwald, M.D.       15,865,232 (2)         73.8% (3)      83,826 (2)          35.6%
787 Seventh Avenue, 48th Floor
New York, NY  10019

Paramount Capital Asset          15,042,741 (4)         72.7% (3)      76,414 (4)          33.5%
Management, Inc.
787 Seventh Avenue
New York, NY  10019

United Congregations Mesora       1,109,600 (5)         16.2%          10,000 (5)           4.4%
c/o Aeta Realty
1 State Street Plaza
New York, NY  10004
Attn:  Chana Adelstein

Branco Weiss                        619,800 (6)          9.9%           5,000 (6)           2.2%
Hallwylstrasse 71
CH-8036 Zurich
SWITZERLAND

Diversified Fund Limited            554,800 (7)          8.8%           5,000 (7)           2.2%
CH-6904 Lugano
Via Zurigo 46
SWITZERLAND

Garo H. Armen                       499,320 (8)          8.0%           4,500 (8)           2.0%
c/o Armen Partners, L.P.
630 Fifth Avenue, Suite 2100
New York, NY  10111


                                     - 14 -


<PAGE>


                                          COMMON STOCK               SERIES D PREFERRED STOCK
                                          ------------               ------------------------

NAME AND ADDRESS OF BENEFICIAL  AMOUNT AND NATURE OF   PERCENT OF   AMOUNT AND NATURE OF   PERCENT
OWNER                          BENEFICIAL OWNERSHIP(1)   CLASS    BENEFICIAL OWNERSHIP(1) OF CLASS

Mark Bercuvitz                      388,360 (9)          6.3%           3,500 (9)           1.5%
1310 Sreene Ave. Suite 660
Westmount, Quebec
CANADA H3Z 2B2

Michael S. Weiss                    148,354 (10)         2.5%           1,337 (10)          0.6%
Robert E. Klem, Ph.D.                28,711 (11)         0.5%               0                 0%
Lawrence J. Kessel, M.D.             27,740 (12)         0.5%             250 (12)          0.1%
Peter Salomon, M.D.                     500 (13)           0%               0                 0%
Glenn L. Cooper, M.D.                     0                0%               0                 0%
Donald G. Drapkin                         0                0%               0                 0%
Kenneth G. Kasses, Ph.D.                  0                0%               0                 0%
Bobby W. Sandage, Jr., Ph.D.              0                0%               0                 0%
Andrew J. Stein                           0                0%               0                 0%
Harlan J. Wakoff                          0                0%               0                 0%
Thomas H. Adams, Ph.D.               61,132 (14)         1.1%               0                 0%
Lauren Brown, Ph.D.                  23,363 (15)         0.4%               0                 0%
Zofia E. Dziewanowska                12,333 (16)         0.2%               0                 0%
Guy Van De Winckel                        0              0.0%               0                 0%

All directors and executive         302,133              5.1%           1,587               0.7%
officers as a group (14 persons)


</TABLE>

(1)  The  number  of  shares   beneficially  owned  is  determined  under  rules
     promulgated by the SEC, and the information is not  necessarily  indicative
     of beneficial ownership for any other purpose. Under such rules, beneficial
     ownership includes any shares as to which the individual has sole or shared
     voting power or investment  power and also any shares which the  individual
     has the right to  acquire  within  60 days of April 1,  1998,  through  the
     exercise or conversion of any stock option,  convertible security,  warrant
     or other right.  The  inclusion  herein of such shares,  however,  does not
     constitute an admission that the named  stockholder is a direct or indirect
     beneficial owner of such shares. Unless otherwise indicated, each person or
     entity  named in the table has sole voting power and  investment  power (or
     shares  such power with his or her  spouse)  with  respect to all shares of
     capital stock listed as owned by such person or entity.

(2)  Dr. Rosenwald may be deemed to have shared voting and investment power over
     the  15,042,741   shares  of  Common  Stock  which  may  be  deemed  to  be
     beneficially owned by Paramount Capital Asset Management,  Inc. ("PCAM") of
     which Dr.  Rosenwald  is the sole  stockholder.  See  Footnote 4 below.  In
     addition,  Dr.  Rosenwald may be deemed to have sole voting and  investment
     power over  approximately  822,491  shares of Common  Stock which he may be
     deemed beneficially to own,  consisting of approximately  785,429 shares of
     Common Stock  issuable  upon  conversion of  approximately  7,412 shares of
     Series D Preferred  Stock issuable upon exercise of Unit Purchase  Warrants
     and  approximately  37,062 shares of Common Stock issuable upon exercise of
     Class D Warrants  issuable  upon exercise of Unit  Purchase  Warrants.  Dr.
     Rosenwald's  beneficial  ownership  excludes  approximately  1,951,801  and
     92,101 shares of Common Stock issuable,  respectively,  upon conversion and
     exercise of  approximately  18,420  shares of Series D Preferred  Stock and
     Class D Warrants  issuable upon exercise of Unit Purchase  Warrants,  which
     are not exercisable within 60 days of April 1, 1998.


                                     - 15 -


<PAGE>

(3)  The  outstanding  shares of Series D  Preferred  Stock of the  Company  are
     entitled to vote  together  with the holders of Common Stock on all matters
     submitted to a vote of  stockholders of the company.  Dr.  Rosenwald may be
     deemed  beneficially  to own  (within  the  meaning of Rule 13d-3 under the
     Securities  Exchange Act of 1934 (the "1934 Act"), as amended) 37.8% of the
     aggregate  voting  power of the Common  Stock and Series D Preferred  Stock
     outstanding.  Similarly, PCAM, Inc. may be deemed beneficially to own 36.6%
     of the  aggregate  voting  power of the Common Stock and Series D Preferred
     Stock outstanding.

(4)  PCAM may be deemed to have  shared  voting  and  investment  power over the
     5,253,866 and 9,788,875 shares of Common Stock, respectively,  which may be
     deemed to be  beneficially  owned by the Aries  Domestic  Fund,  L.P.  (the
     "Aries  Domestic  Fund") and The Aries Fund,  a Cayman  Islands  Trust (the
     "Aries  Trust"  and,  together  with the Aries  Domestic  Fund,  the "Aries
     Funds"),  for which PCAM is the  General  Partner and  Investment  Advisor,
     respectively.  PCAM's  beneficial  ownership  includes:  27,450  and 64,050
     shares  of  Common  Stock  held by Aries  Domestic  Fund and  Aries  Trust,
     respectively;  2,833,907 and 5,262,940 shares of Common Stock issuable upon
     conversion of approximately  26,745 and 49,669 shares of Series D Preferred
     Stock  (including  350 and 650 shares of Series D Preferred  Stock issuable
     upon exercise of Unit Purchase  Warrants)  held by Aries  Domestic Fund and
     Aries  Trust,  respectively;  19,250  and  35,750  shares of  Common  Stock
     issuable upon exercise of Class D Warrants (including 1,750 and 3,250 Class
     D Warrants issuable upon exercise of Unit Purchase  Warrants) held by Aries
     Domestic  Fund and Aries  Trust,  respectively;  approximately  130,593 and
     261,185  shares of Common Stock issuable upon exercise of 18,000 and 36,000
     shares of Series A Preferred  Stock held by Aries  Domestic  Fund and Aries
     Trust, respectively;  Bridge Warrants held by Aries Domestic Fund and Aries
     Trust to purchase  approximately  2,225,166 and 4,132,450  shares of Common
     Stock,  respectively;  and Line of Credit  Warrants held by Aries  Domestic
     Fund and Aries Trust to purchase  17,500 and 32,500 shares of Common Stock,
     respectively.

(5)  United  Congregations  Mesora's  beneficial  ownership  consists  of 10,000
     shares  of  Series  D  Preferred   Stock,   which  are   convertible   into
     approximately  1,059,600  shares of Common  Stock,  and Class D Warrants to
     purchase up to 50,000 shares of Common Stock.  This  information is derived
     from United Congregations Mesora's Schedule 13D, as amended, dated July 11,
     1997, filed with the SEC.

(6)  Mr. Branco Weiss' beneficial ownership consists of 5,000 shares of Series D
     Preferred Stock, which are convertible into approximately 529,800 shares of
     Common  Stock,  Class D Warrants to purchase up to 25,000  shares of Common
     Stock and 65,000 shares of Common Stock.  This  information is derived from
     Mr. Weiss' Schedule 13D dated October 9, 1997, filed with the SEC.

(7)  Diversified Fund Limited's ("Diversified's")  beneficial ownership consists
     of 5,000 shares of Series D Preferred  Stock,  which are  convertible  into
     approximately  529,800  shares of Common  Stock,  and Class D  Warrants  to
     purchase up to 25,000 shares of Common Stock. Carlo Pagani, in his capacity
     as President  of  Diversified,  shares  voting and  dispositive  power with
     respect to such securities and may be deemed to be the beneficial  owner of
     such securities.  This information is derived from  Diversified's  Schedule
     13D dated March 2, 1998, filed with the SEC.

(8)  Dr.  Armen's  beneficial  ownership  consists  of 4,500  shares of Series D
     Preferred Stock, which are convertible into approximately 476,820 shares of
     Common  Stock,  and Class D Warrants  to  purchase  up to 22,500  shares of
     Common  Stock.  The Series D Preferred  Stock and the Class D Warrants  are
     held by (a) Armen Partners,  L.P., an investment  limited  partnership,  of
     which Dr. Armen and Armen Capital  Management Corp., a corporation of which
     Dr. Armen is the principal,  are the general  partners,  (b) Armen Partners
     Offshore  Fund,  Ltd., an offshore  investment  fund to which Armen Capital
     Management  Corp.  acts as  investment  manager,  and  (c)  GHA  Management
     Corporation, a corporation wholly-owned by Dr.


                                     - 16 -


<PAGE>

     Armen. This information is derived from Dr. Armen's Schedule 13D dated July
     24, 1997, filed with the SEC.

(9)  Mr. Bercuvitz's  beneficial  ownership consists of 3,500 shares of Series D
     Preferred Stock, which are convertible into approximately 370,860 shares of
     Common  Stock,  and Class D Warrants  to  purchase  up to 17,500  shares of
     Common Stock. This information is derived from Mr. Bercuvitz's Schedule 13D
     dated March 2, 1998, filed with the SEC.

(10) Mr. Michael Weiss' beneficial  ownership  consists of approximately  15,894
     shares of Common Stock  issuable upon  conversion of 150 shares of Series D
     Preferred Stock; 750 shares of Common Stock issuable upon exercise of Class
     D Warrants;  and  approximately  125,775 and 5,935  shares of Common  Stock
     issuable, respectively, upon conversion and exercise of approximately 1,187
     shares of Series D  Preferred  Stock and  Class D  Warrants  issuable  upon
     exercise  of  Unit  Purchase  Warrants.  Mr.  Weiss'  beneficial  ownership
     excludes 502,993 and 23,735 shares of Common Stock issuable,  respectively,
     upon  conversion  and  exercise of  approximately  4,747 shares of Series D
     Preferred  Stock  and  Class D  Warrants  issuable  upon  exercise  of Unit
     Purchase  Warrants,  which are not  exercisable  within 60 days of April 1,
     1998, that are held by an entity of which Mr. Weiss is the managing member.
     Mr. Weiss' business address is 787 Seventh Avenue, New York, NY 10019.

(11) Dr. Klem's beneficial  ownership  consists of 23,358 shares of Common Stock
     and options to purchase  5,353 shares of Common  Stock.  Dr.  Klem's Common
     Stock holdings include 1,875 shares of Common Stock held by a trust for Dr.
     Klem's  children,  as to which Dr.  Klem has shared  voting and  investment
     power, and 150 shares of Common Stock owned by Dr. Klem's wife, as to which
     he disclaims beneficial ownership.

(12) Dr.  Kessel's  beneficial  ownership  consists  of 250  shares  of Series D
     Preferred Stock, which are convertible into approximately  26,490 shares of
     Common Stock, and Class D Warrants to purchase up to 1,250 shares of Common
     Stock.

(13) Dr. Salomon's beneficial ownership consists of 500 shares of Common Stock.

(14) Dr. Adams' beneficial  ownership  consists of 38,333 shares of Common Stock
     and options to purchase  22,799 shares of Common  Stock.  Dr. Adams' Common
     Stock holdings  include 8,000 shares of Common Stock held in several trusts
     for Dr.  Adams'  children,  as to which Dr.  Adams has  shared  voting  and
     investment  power,  and 30,333  shares of Common Stock jointly owned by Dr.
     Adams and Dr.  Adams'  wife,  as to which Dr.  Adams has shared  voting and
     investment  power. Dr. Adams' options shown in the table exclude options to
     purchase  100,000  shares of Common  Stock that were  granted to him in May
     1998  pursuant to a consulting  services  agreement.  See Footnote 2 to the
     Summary Compensation Table, below.

(15) Dr. Brown's beneficial  ownership consists of 20,078 shares of Common Stock
     and options to purchase 3,285 shares of Common Stock.

(16) Dr.  Dziewanowska's  beneficial  ownership  consists of options to purchase
     12,333 shares of Common Stock.


                                LEGAL PROCEEDINGS

        LBC Capital Resources, Inc. ("LBC"), a Philadelphia-based broker/dealer,
has asserted claims against the Company and others,  including Paramount Capital
Inc., of which Dr. Rosenwald is the sole stockholder and Mr.


                                     - 17 -


<PAGE>

Weiss is a Senior Managing  Director,  and various related entities and persons.
LBC's  claims  relate to the  alleged  breach by the  Company of certain  letter
agreements,  allegedly entered into by LBC and the Company in 1995 and 1996 with
respect  to  brokerage  and/or  investment  banking  services,  particularly  in
connection  with a $3 million  investment,  for which LBC is  seeking a fee.  In
April 1998, a Complaint  was filed in the United States  District  Court for the
Southern  District of New York (98 Civ. 2491) by LBC against the Company and the
same other parties.  The Company is currently engaged in settlement  discussions
with LBC.


        On June 4,  1998,  the  Company's  statutory  process  agent  received a
Summons and Complaint in a lawsuit  brought by Johns Hopkins against the Company
in Maryland Circuit Court for Baltimore City (Case No. 98120110).  Johns Hopkins
alleges  in the  Complaint  that the  Company  has  breached  the Johns  Hopkins
Agreement  (as defined  below) and owes it  licensing  royalty  fees and related
expenses in the amount of $308,832.24.  Johns Hopkins also alleges the existence
of a separate March 1993 letter agreement  wherein the Company agreed to support
a fellowship  program at the Johns  Hopkins  School of Hygiene and Public Health
and the Company's  breach thereof,  with damages of $326,829.00.  The Company is
currently in the process of retaining  Maryland  counsel so that it can properly
evaluate these lawsuit documents and respond.



                             EXECUTIVE COMPENSATION

        The  following  table  sets  forth  compensation  for  services  in  all
capacities to the Company,  for the fiscal years ended  December 31, 1995,  1996
and 1997,  of: (i) those persons who were,  respectively,  the  Company's  Chief
Executive  Officer for any time  period  during 1997 and up to four of the other
most highly  compensated  executive  officers of the Company who were serving as
executive  officers at December 31, 1997 whose total annual salary and bonus for
the fiscal year ending December 31, 1997 exceeded  $100,000;  and (ii) up to two
additional  individuals  who would have been two of such other four most  highly
compensated  executive  officers  if such  individuals  had served as  executive
officers for the entire fiscal year (collectively, the "Named Officers").

                           SUMMARY COMPENSATION TABLE


<TABLE>
<CAPTION>
                                                                                                    LONG-TERM
                                                                                                   COMPENSATION
                                              ANNUAL COMPENSATION                                   AWARDS
                           ---------------------------------------------------------      --------------------------

Name and                                                            Other Annual            Securities Underlying
Principal Position           Year       Salary ($)    Bonus ($)     Compensation                 Options (#)
- ------------------           ----       ----------    ---------     ------------                 -----------

<S>                          <C>        <C>              <C>            <C>                          <C>       
Thomas H. Adams, Ph.D.       1997      $285,000(1)        --             --                          100,000(2)
Chairman of the Board and    1996       285,000(3)        --             --                            2,799(3)
Chief Executive Officer      1995       285,000(3)        --             --                           20,000(4)

Kenneth G. Kasses, Ph.D.     1997        62,500(5)        --             --                            --
President and
Chief Executive Officer

Zofia E. Dziewanowska        1997      $216,601(6)        --             --                            --
Ph.D., M.D., Senior Vice     1996       235,000(3)        --             --                            1,574(3)
President, Global Clinical   1995       235,000(3)        --          14,759(7)                       12,000(4)
Affairs

Guy Van de Winckel           1997      $170,000(8)        --             --                           --
Vice President, European     1996       170,000           --             --                           --
Operations and President of  1995       170,000           --             --                           --
Genta Pharmaceuticals
Europe, S.A.


                                           - 18 -


<PAGE>



Robert E. Klem, Ph.D.        1997      $170,000(9)        --             --                            --
Vice President, Chairman of  1996       155,000(3)        --          2,580(10)                          853(3)
the Board of JBL             1995       161,458(3)(11)    --          2,580(10)                        4,500(4)

Lauren Brown, Ph.D.          1997       144,000(9)        --             --                            --
President JBL                1996       131,000(3)        --          3,000(10)                        1,285(3)
                             1995       131,000(3)        --          3,000(10)                        2,000(4)


</TABLE>

(1)  Dr. Adams resigned as Chief Executive Officer and Chairman of the Board and
     a Director on May 5, 1997. Pursuant to severance and consulting  agreements
     with the Company,  the Company  agreed to continue to pay Dr. Adams' salary
     at the then-current rate of $285,000 per year for a one-year period, agreed
     to continue  eligibility for coverage under the Company's  health insurance
     plan for a one-year period and agreed to grant options to purchase  100,000
     shares of Common  Stock  exercisable  at $3.00 per share  (100% of the fair
     market value of such stock on May 5, 1997) as consideration  for consulting
     services of at least 24 days.

(2)  See Footnote 1 above. These options were granted to Dr. Adams in May 1998.

(3)  Options were granted to Named  Officers  during the year ended December 31,
     1996 to compensate them for accepting  deferral of the payment of a portion
     of base salary in 1995 and 1996.  The  portions of salaries so deferred are
     included in the 1995 salary  figures in this table,  consisting of $23,750,
     $9,792,  $6,458 and $10,916 for Drs. Adams,  Dziewanowska,  Klem and Brown,
     respectively,  and in the 1996 salary figures in this table,  consisting of
     $11,875, $9,791, $6,458 and $5,458 for Drs. Adams,  Dziewanowska,  Klem and
     Brown, respectively.

(4)  These options (the "New Options") were granted in exchange for  unexercised
     options granted prior to April 20, 1995 with an exercise price above $22.50
     per share (the "Old Options").  The New Options were granted at fair market
     value at the date of grant and have the same  vesting  schedule  as the Old
     Options.  However,  the New Options were not exercisable  until after April
     20, 1997,  regardless  of the Old  Options'  vesting  schedule,  unless the
     holder was terminated  involuntarily without cause prior to April 20, 1997.
     None of these options have been exercised to date.

(5)  Salary  payments  commenced  on  October  1,  1997.  See  "Compensation  of
     President and Chief Executive Officer" below.

(6)  Dr.  Dziewanowska  resigned as Senior  Vice  President  of Global  Clinical
     Affairs  on July  31,  1997.  Pursuant  to  severance  agreements  with the
     Company, the Company agreed to continue to pay Dr. Dziewanowska's salary at
     the  then-current  rate of  $235,000  per year for the  first  month and at
     one-half the then-current  rate for the next ten months.  In addition,  the
     Company  agreed to continue  eligibility  for coverage  under the Company's
     dental  insurance plan and to pay Dr.  Dziewanowska  monthly dollar amounts
     equal to the group medical  premiums under the Company's  health  insurance
     plan for an eleven-month period.

(7)  Represents  payments for expenses  incurred in connection  with  relocation
     including applicable tax gross-ups.

(8)  Mr. Van de Winckel  resigned as Vice  President of European  Operations and
     President of Genta Pharmaceuticals Europe, S.A. on April 15, 1997. Pursuant
     to a severance  arrangement with the Company,  the Company continued to pay
     Mr. Van de Winckel's salary at the  then-current  rate of $170,000 per year
     and agreed to continue  eligibility for coverage under the Company's health
     insurance plan for a nine-month period.

(9)  This amount does not include the payment in 1997 of the full salary amounts
     deferred from 1995 and 1996, as discussed in Footnote 3 above.


                                     - 19 -


<PAGE>


(10) Represents payments for insurance policies covering Drs. Klem and Brown.

(11) Represents  25 bimonthly  pay periods  during 1995 that  resulted  from Dr.
     Klem's having been transferred from the Company's payroll calendar to JBL's
     payroll calendar.

COMPENSATION OF PRESIDENT AND CHIEF EXECUTIVE OFFICER

        Pursuant to a Letter Agreement dated September 4, 1997,  between Michael
Weiss,  then the Interim Chairman of the Board of the Company (and presently the
Vice  Chairman),  and Dr.  Kasses  (the  "Letter  Agreement"),  Dr.  Kasses  was
appointed  President  and Chief  Executive  Officer  of the  Company,  effective
October 1, 1997,  subject to Board  ratification.  Among other items, the Letter
Agreement provided the following:

        1. Dr. Kasses would receive a base salary of $300,000 per annum, subject
to semi-annual  review commencing on October 1, 1998. In the event Dr. Kasses is
terminated  without cause or terminates  his  employment  for cause,  Dr. Kasses
would become entitled to receive this amount as severance for one year following
such  termination,  subject to  set-off  for  amounts  earned  from  alternative
employment.  At the end of Dr. Kasses' first year of employment, he would become
entitled to a bonus of  $100,000,  assuming he is then  employed by the Company.
Dr.  Kasses  would also be entitled to an  additional  bonus of up to  $100,000,
subject to achievement of agreed-upon milestones.

        2. Dr.  Kasses  would be  entitled to  receive,  subject to  stockholder
approval,  a grant of stock options to purchase 5% of the fully  diluted  Common
Stock of the Company  outstanding  as of an  agreed-upon  date,  with  quarterly
vesting over four years (assuming continued employment).

        3. Dr. Kasses and his dependents  would receive such medical,  long-term
disability,  life insurance and such other health  benefits as the Company makes
available to its other senior officers and directors.

        The  Letter  Agreement   contemplated   that  these  and  certain  other
provisions would be incorporated into an employment agreement between Dr. Kasses
and the Company.

        The Company is seeking  stockholder  approval of a stock  option plan at
this Annual  Meeting of  Stockholders  (see Proposal Five) pursuant to which the
stock  options  referred  to in the  Letter  Agreement  would be  granted.  (The
Company's  current  stock  option  plan has  insufficient  shares to permit such
grant.)

COMPENSATION OF DIRECTORS

        Directors of the Company receive no fees for their services as directors
or committee members.  Non-employee  directors are reimbursed by the Company for
their  out-of-pocket  expenses  incurred in  attending  meetings of the Board of
Directors and its  committees  and receive  annual grants of stock options under
the  Company's  1991 Stock  Option  Plan.  The  Company  is seeking  stockholder
approval of stock  option  plans at this  Annual  Meeting of  Stockholders  (see
Proposals Five and Six) pursuant to which  directors will be eligible to receive
stock option grants.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

        For the Company's  fiscal year ended  December 31, 1997, the Company had
no  Compensation  Committee.  The  entire  Board of  Directors  participated  in
discussions  regarding  compensation matters. None of the directors or executive
officers of the Company had any  "interlock"  relationship  to report during the
Company's  fiscal year ended December 31, 1997. See "Certain  Relationships  and
Related  Transactions"  for a description  of certain  arrangements  between the
Company  and Genta  Jago.  Genta's  Vice  Chairman  of the  Board is a  managing
director of Genta Jago.

PENSION AND LONG-TERM INCENTIVE PLANS

        The Company has no pension or long-term incentive plans.


                                     - 20 -


<PAGE>

                                  STOCK OPTIONS

        No stock  options  were  issued to any Chief  Executive  Officer,  Named
Executive  Officer or Director by the Company in 1997.  See Footnotes 1 and 2 to
the Summary Compensation Table.

                           OPTION EXERCISES IN LAST FISCAL YEAR AND
                                FISCAL YEAR END OPTION VALUES


<TABLE>
<CAPTION>
                                                                       Number of      
                                                                      Securities                                 Value of       
                                                                      Underlying                                Unexercised     
                                                                      Unexercised                              In-the-Money     
                                                                      Options at                                Options at      
                                                                  Fiscal Year End(#)                       Fiscal Year End($)(1)
                                                                  ------------------                       ---------------------
                      Shares Acquired         Value                                                           
Name                  On Exercise (#)      Realized ($)     Exercisable        Unexercisable        Exercisable     Unexercisable
- ----                  ---------------      ------------     -----------        -------------        -----------     -------------

<S>                          <C>              <C>            <C>                <C>                    <C>            <C>
Thomas H. Adams, Ph.D.       --               --             22,799              --(2)                 --             --

Kenneth G. Kasses, Ph.D.     --               --                 --              --                    --             --

Zofia E. Dziewanowska,
  Ph.D., M.D.                --               --             12,333           1,240                    --             --

Guy Van de Winckel           --               --                 --              --                    --             --

Robert E. Klem, Ph.D.        --               --              5,353              --                    --             --

Lauren Brown, Ph.D.                                           3,285              --                    --             --

</TABLE>

(1)  Calculated  on the  basis  of  the  fair  market  value  of the  underlying
     securities  as of December  31, 1997 ($.781 per share),  minus the exercise
     price.

(2)  Does not include  options to purchase  100,000 shares of Common Stock which
     were  granted to Dr. Adams in May 1998  pursuant to a  consulting  services
     agreement.


                  BOARD REPORT TO STOCKHOLDERS ON COMPENSATION

OVERVIEW

        During  1997  the  Board of  Directors  had no  Compensation  Committee.
Accordingly, this Report is being made by the full Board of Directors.

        The Company seeks to achieve three  objectives which serve as guidelines
in making compensation decisions:

     o    Providing  a total  compensation  package  which is  competitive  and,
          therefore,  enables the Company to attract and retain,  on a long-term
          basis, high-caliber executive personnel;

     o    Integrating  compensation  programs with the Company's  short-term and
          long-term strategic plan and business objectives; and


                                     - 21 -


<PAGE>

     o    Encouraging  achievement  of business  objectives  and  enhancement of
          stockholder  value  by  providing   executive   management   long-term
          incentive through equity ownership.

        In making its  compensation  determinations,  the Board of Directors and
prior years'  Compensation  Committees  have  relied,  in part,  on  independent
surveys and analyses of  management  compensation  of executives of companies in
the  biotechnology and  pharmaceutical  industries  (including  companies in the
Nasdaq  Pharmaceutical Stock Index used in the Company's Stock Price Performance
Graph set forth in this Proxy Statement) and recommendations of management.  The
Board of Directors  believes it has established  executive  compensation  levels
which are competitive  with companies in the  biotechnology  and  pharmaceutical
industries when taking into account relative company size, stage of development,
individual  responsibilities  and experience,  individual and overall  corporate
performance and geographic location.

COMPONENTS OF EXECUTIVE COMPENSATION

        The Company's  potential  therapeutic  products are in various stages of
research  and  development,  and no  revenues  have as yet been  generated  from
therapeutic  product  sales.  As a result,  the use of  traditional  performance
standards,  such as corporate profitability,  are not believed to be appropriate
in  the  evaluation  of  the  performance  of  the  Company  or  its  individual
executives.  The compensation of the Company's  executive  officers is based, in
substantial  part,  on the  achievement  of  individual  and  overall  corporate
objectives. Such objectives are established and modified as necessary to reflect
changes in market conditions and other factors. Individual and overall corporate
performance is measured by reviewing  whether these  corporate  objectives  have
been achieved.

        The  Company's  compensation  package for executive  officers  generally
consists of annual cash  compensation and long-term  compensation in the form of
stock  options.  In light of the Company's  stage of  development,  considerable
emphasis is placed on equity-based compensation in an effort to preserve cash to
finance the Company's research and development efforts.

ANNUAL CASH COMPENSATION

        Compensation levels for the Company's executive officers are determined,
in  part,  through  comparisons  with  companies  of a  similar  size,  stage of
development  and level of complexity  in the  biotechnology  and  pharmaceutical
industries,  and other companies with which the Company  competes for personnel.
In addition,  the  compensation  level for each  executive  officer  reflects an
evaluation  of the  responsibilities  required  for  each  respective  position,
individual  experience  levels,  and individual  performance  and  contributions
toward achievement of the Company's business objectives. The compensation levels
for the Company's  executive  officers are designed to be  competitive  within a
range that the Board of Directors or the Compensation Committee determines to be
reasonable  in light of the  aforementioned  factors.  The salary levels of each
executive  officer are reviewed on an annual basis and  adjustments  are made as
deemed necessary.

STOCK OPTIONS

        The Board of Directors  of the Company  believes  that by providing  all
full-time  employees,  including  executive officers who have responsibility for
the  management  and growth of the  Company,  with an  opportunity  to obtain an
equity  interest in the  Company,  the best  interests of  stockholders  and its
employees  will  be  closely  aligned.  Accordingly,  all  full-time  employees,
including executive  officers,  are eligible to receive stock option grants from
time to time,  giving them the right to purchase shares of the Company's  Common
Stock at a specified price. See Proposal Five.

COMPENSATION OF EXECUTIVE OFFICERS

        In making  compensation  decisions for 1997, the Board of Directors took
into account the  Company's  limited  cash  resources,  its  weakened  financial
condition, the general financial performance of the Company during 1996 and 1997
and the  importance of retaining the Company's  cash to finance its  development
programs.  The Board of Directors also  considered the importance to the Company
of retaining highly qualified key personnel due


                                     - 22 -


<PAGE>

to the  complex  and  technologically  sophisticated  nature  of  the  Company's
business.  In light of these factors, it was decided not to grant bonuses to any
executive  officer but to increase the base salary of Drs.  Klem and Brown based
on JBL's performance during 1996 and, in the case of Dr. Klem, in recognition of
his increased  management  responsibilities  at Genta during 1997. The salary of
Dr.  Kenneth  G.  Kasses,  who was hired as the  Company's  President  and Chief
Executive Officer effective October 1, 1997, was determined through  negotiation
with the Interim Chairman of the Board. See "Compensation of President and Chief
Executive Officer" above.

CODE SECTION 162(M)

        In 1993,  the  Internal  Revenue  Code (the  "Code")  was amended to add
Section  162(m).  Section  162(m)  places a limit of $1,000,000 on the amount of
compensation  that may be deducted by a public  company in any year with respect
to certain of the company's higher paid executives.  Certain  performance  based
compensation  that has been  approved  by  shareholders  is not  subject  to the
deduction limitation. The 1998 cash compensation of the Company's executives was
well below the level where this  limitation  would  apply.  See  Proposal  Five,
"Limitations  on the Company's  Compensation  Deduction" for  discussions of the
applicability of Section 162(m) to the Company's 1998 Stock Incentive Plan.

        This Compensation  Report shall not be deemed  incorporated by reference
by any general  statement  incorporating  by reference this Proxy Statement into
any filing under the Securities Act of 1933, as amended,  or under the 1934 Act,
as amended,  except to the extent the  Company  specifically  incorporates  this
report by reference, and shall not otherwise be deemed filed under such Acts.

                                            Glenn L. Cooper, M.D.

                                            Donald G. Drapkin

                                            Kenneth G. Kasses, Ph.D.

                                            Lawrence J. Kessel, M.D.

                                            Robert E. Klem, Ph.D.

                                            Peter Salomon, M.D.

                                            Bobby W. Sandage, Jr., Ph.D.

                                            Andrew J. Stein

                                            Harlan J. Wakoff

                                            Michael S. Weiss


                                     - 23 -


<PAGE>

                          STOCK PRICE PERFORMANCE GRAPH

        The following graph illustrates a comparison of the five-year cumulative
total  stockholder  return (change in stock price plus reinvested  dividends) of
the  Company's  Common  Stock  with the CRSP Total  Return  Index for The Nasdaq
National Market (U.S. and Foreign) (the "Nasdaq  Composite  Index") and the CRSP
Total Return Index for Nasdaq Pharmaceutical Stocks (the "Nasdaq  Pharmaceutical
Index").  The  comparisons  in the  graph  are  required  by the SEC and are not
intended to forecast or be  indicative  of possible  future  performance  of the
Company's Common Stock.


                                      [GRAPHIC OMITTED]

<TABLE>
<CAPTION>
                       December 31,  December 31,  December 31, December 31,  December 31,  December 31,
                           1992          1993          1994         1995          1996          1997

<S>                         <C>         <C>           <C>          <C>            <C>           <C>  
Genta Incorporated.......   $100        $81.94        $57.70       $25.33         $4.93         $0.88
Nasdaq Composite........     100        115.76        112.28       157.69        198.10        236.22
Nasdaq Pharmaceutical...     100         89.43         67.08       122.72        123.08        127.18

</TABLE>


        Assumes a $100  investment on December 31, 1992 in each of the Company's
Common Stock,  the securities  comprising the Nasdaq  Composite  Index,  and the
securities comprising the Nasdaq Pharmaceutical Index.

- -------------------------



1 The Nasdaq  Pharmaceutical  Index  includes all companies on Nasdaq within SIC
code  283.  A  copy  of  the  list  of  companies   which  comprise  the  Nasdaq
Pharmaceutical   Index  may  be  obtained  upon  request  by  contacting   Genta
Incorporated,  Investor  Relations,  3550  General  Atomics  Court,  San  Diego,
California 92121 (619) 455-2700.


                                     - 24 -


<PAGE>

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

        In February 1989, the Company entered into a license agreement with Drs.
Paul Ts'o and Paul Miller (the "Ts'o/Miller  Agreement")  pursuant to which Drs.
Ts'o and Miller  granted an exclusive  license to the Company to certain  issued
patents, patent applications and related technology regarding the use of nucleic
acids and  oligonucleotides,  including  methylphosphonates,  as  pharmaceutical
agents. Dr. Ts'o was a Director of the Company until September 11, 1997 and is a
Professor of Biophysics,  Department of Biochemistry  at Johns Hopkins,  and Dr.
Miller is a  Professor  of  Biochemistry  at the  School of  Public  Health  and
Hygiene,  Johns  Hopkins.  In May,  1990,  the  Company  entered  into a license
agreement with Johns Hopkins (the "Johns Hopkins Agreement," and such agreement,
together  with the  Ts'o/Miller  Agreement,  being  referred  to  herein  as the
"Ts'o/Miller/Hopkins  Agreements")  pursuant to which Johns Hopkins  granted the
Company an exclusive  license to its rights in certain  issued  patents,  patent
applications and related technology  developed as a result of research conducted
at Johns Hopkins by Drs. Ts'o and Miller and related to the use of nucleic acids
and obligonucleotides as pharmaceutical  agents. In addition,  Johns Hopkins has
granted the Company  certain rights of first  negotiation to inventions  made by
Drs. Ts'o and Miller in their laboratories in the area of  oligonucleotides  and
inventions  made by  investigators  at Johns  Hopkins in the course of  research
funded by the  Company,  which  inventions  are not  otherwise  included  in the
Ts'o/Miller/Hopkins  Agreements.  The Company agreed to pay Dr. Ts'o, Dr. Miller
and Johns  Hopkins  royalties  on net sales of  products  covered  by the issued
patents and patent applications, but not the related technology, licensed to the
Company under the Ts'o/Miller/Hopkins  Agreement. The Company also agreed to pay
certain minimum  royalties  prior to  commencement  of commercial  sales of such
products,  which  royalties  may be credited  under certain  conditions  against
royalties  payable on  subsequent  sales.  Subject  to  certain  rights of early
termination, the Ts'o/Miller/Hopkins Agreements remain in effect for the life of
the  last-to-expire  patent  licensed under the  respective  agreements or until
abandonment of the last-pending patent application licensed under the respective
agreements.  On May 15, 1997,  Johns  Hopkins sent the Company a letter  stating
that the Johns  Hopkins  Agreement  was  terminated.  On  November  26, 1997 the
Ts'o/Miller  Partnership sent the Company a letter claiming that the Company was
in material  breach of the  Ts'o/Miller  Agreement  for failing to pay royalties
from 1995 through 1997.  This notice further  advised that if the alleged breach
were not cured within 90 days of the notice the license would be terminated.  On
June 4, 1998,  the  Company's  statutory  process  agent  received a Summons and
Complaint in a lawsuit  brought by Johns Hopkins against the Company in Maryland
Circuit Court for Baltimore City (Case No.  98120110).  Johns Hopkins alleges in
the Complaint that the Company has breached the Johns Hopkins Agreement and owes
it  licensing  royalty fees and related  expenses in the amount of  $308,832.24.
Johns  Hopkins  also  alleges  the  existence  of a separate  March 1993  letter
agreement  wherein the  Company  agreed to support a  fellowship  program at the
Johns  Hopkins  School of Hygiene  and Public  Health and the  Company's  breach
thereof, with damages of $326,829.00. The Company is currently in the process of
retaining  Maryland  counsel  so that it can  properly  evaluate  these  lawsuit
documents  and  respond.  See  "Business  --  Anticode(TM)  Brand  of  Antisense
Oligonucleotide   Programs   --Oligonucleotide   Collaborative   and   Licensing
Agreements --  Ts'o/Miller/Hopkins" in the Company's Annual Report on Form 10-K,
as amended,  for the year ended  December  31,  1997.  The Company is  currently
engaged  in  settlement  discussions  with  Johns  Hopkins  and the  Ts'o/Miller
partnership.

        In February 1991, in connection with the acquisition of JBL, the Company
assumed certain leases between JBL and Granada Associates and Sueldo Associates,
both of which are affiliates of Drs. Brown and Klem. Dr. Brown is currently Vice
President of the Company and President of JBL. Dr. Klem is Vice  President and a
Director of the Company and Chairman of the Board of JBL. The current  aggregate
monthly payment under such leases is approximately $32,000.

        Dr. Thomas H. Adams resigned as the Chief Executive Officer and Chairman
of the Board of the  Company on May 5,  1997.  As of May 6,  1997,  the  Company
entered  into a  consulting  agreement  with Dr.  Adams,  pursuant  to which the
Company  has  granted  options  to  purchase  100,000  shares  of  Common  Stock
exercisable  at $3.00  per  share as  consideration  for Dr.  Adams'  performing
consulting services of at least 24 days. These options will vest over a two-year
period  commencing on May 5, 1997, except that the vesting will terminate if Dr.
Adams fails to fulfill his  obligations  under the  agreement  or if the Company
terminates the agreement for cause. In addition,  Dr. Adams' previously  granted
options will continue to vest until the end of the 90-day post-termination grace
period for the options  which  commenced  on May 5, 1998.  See Footnote 1 to the
Summary  Compensation Table for a description of Dr. Adams' severance  agreement
with the Company.

        As of August 1, 1997,  the Company  entered into a consulting  agreement
with Dr. Zofia E.  Dziewanowska  (a former  executive  officer of the  Company),
pursuant to which Dr.  Dziewanowska  would be compensated for any work performed
at a rate  of $150  per  hour  through  January  31,  1998  and  $300  per  hour
thereafter.  In addition, Dr. Dziewanowska's options continued to vest until the
end of the 90-day post-termination exercise grace period


                                     - 25 -


<PAGE>

for the options,  which  commenced  on January 31,  1998.  See Footnote 6 to the
Summary  Compensation  Table for a description of Dr.  Dziewanowska's  severance
agreement with the Company.

        As of August 27,  1997,  the Company  entered into  separate  consulting
agreements with each of Drs. Paul Ts'o and Sharon Webster (both former directors
of the  Company),  pursuant to which the Company  issued 15,400 shares of Common
Stock to Dr. Ts'o and 15,500 shares of Common Stock to Dr. Webster,  paid $4,000
to Dr.  Webster  and  retained  each  of Drs.  Ts'o  and  Webster  to  serve  as
consultants to the Company for a one-year period at a fee of $12,000.

        In February  1997,  the Company raised gross proceeds of $3 million in a
private placement,  to the Aries Funds, of 12% Senior Secured  Convertible Notes
("Convertible Notes") and Bridge Warrants.  The Convertible Notes, together with
accrued  interest  thereon,  were  converted  pursuant  to their  terms  into an
aggregate  of  65,415  shares  of Series D  Preferred  Stock,  which in turn are
convertible,  at $0.94375 per share,  into 6,931,391 shares of Common Stock. The
Bridge Warrants permit the purchase of up to an aggregate of 6,357,616 shares of
Common Stock at an exercise  price of $0.471875 per share (subject to adjustment
upon the  occurrence  of  certain  events).  Pursuant  to the  Note and  Warrant
Purchase Agreement in connection with such private placement,  the Company could
be required to issue Penalty  Warrants to the Aries Funds.  See  "Proposal  One:
Approval of Reverse  Stock Splits of the Company's  Outstanding  Common Stock --
Capitalization."  Also pursuant to the Note and Warrant Purchase Agreement,  the
Aries Funds were granted the right to designate nominees constituting a majority
of the  members of the Board of  Directors  of the  Company,  subject to certain
conditions.  The Aries  Funds  designated  Michael  S.  Weiss as a  nominee  for
Director and he was appointed by the Board and elected  Interim  Chairman of the
Company's Board of Directors.  On September 11, 1997, the Aries Funds designated
Glenn L. Cooper,  M.D.,  Donald G. Drapkin,  Bobby W. Sandage,  Jr.,  Ph.D.  and
Andrew J.  Stein as  nominees  to the Board of  Directors  of the  Company  (the
"Board"),  such persons  were  elected as  Directors of the Company,  Michael S.
Weiss  stepped  down as  Interim  Chairman  and the Board  elected  Mr.  Drapkin
Chairman and Mr. Weiss Vice Chairman.

        On June 6, 1997, the Aries Funds entered into a Line of Credit Agreement
with the Company  pursuant to which the Aries Funds  provided the Company with a
line  of  credit  of  up  to  $500,000,   which   subsequently  was  repaid,  in
consideration  for warrants (the "Line of Credit  Warrants") to purchase  50,000
shares of Common Stock  exercisable  at $2.50 per share,  subject to  adjustment
upon the occurrence of certain events.

        On June 30, 1997, the Company sold a total of 161.58  Premium  Preferred
Units(TM)  ("Units") in a private placement (the "Private  Placement") for which
Paramount Capital,  Inc. acted as placement agent. Each unit sold in the Private
Placement  consisted  of 1,000  shares of Series D  Preferred  Stock and Class D
Warrants to purchase 5,000 shares of Common Stock at any time prior to the fifth
anniversary  of the final closing date. A total of $16,158,000  was raised.  The
net proceeds to the Company were $14,036,772. The conversion price of the Series
D  Preferred  Stock  and the  exercise  price of the Class D  Warrants  are both
$0.94375 per share, subject to adjustment upon the occurrence of certain events.
The Aries Funds  purchased,  for an aggregate of $870,000,  Class D Warrants and
Series D Preferred  Stock in the Private  Placement  presently  exercisable  and
convertible  for  aggregates  of 50,000 and  1,059,603  shares of Common  Stock,
respectively. In connection with the Private Placement,  Paramount Capital, Inc.
received  cash  commissions  equal  to  9%  of  the  gross  sales  price  and  a
non-accountable  expense  allowance  equal to 4% of the gross sales  price,  and
received warrants (the "Placement  Warrants") to purchase up to 10% of the Units
sold  in the  Private  Placement  for  110%  of the  offering  price  per  Unit.
Furthermore, the Company has agreed to enter into a financial advisory agreement
with Paramount  Capital,  Inc. pursuant to which Paramount  Capital,  Inc. shall
receive  certain cash fees and has received  warrants (the  "Advisory  Warrants"
and,  together with the Placement  Warrants,  the "Unit  Purchase  Warrants") to
purchase  up to 15% of the Units sold in the Private  Placement  for 110% of the
offering  price per Unit.  Michael S. Weiss,  Vice  Chairman of the Board of the
Company,  is a Senior  Managing  Director of Paramount  Capital,  Inc.  David R.
Walner, the Secretary of the Company,  is an Associate Director and Secretary of
Paramount  Capital  Asset  Management,  Inc.  ("PCAM").  PCAM is the  investment
manager  and  general   partner  of  Aries  Trust  and  Aries   Domestic   Fund,
respectively.  The Aries  Funds  currently  do not hold a  controlling  block of
voting stock of the Company,  although the Aries Funds have the present right to
convert  and  exercise  their  securities  into  a  significant  portion  of the
outstanding  Common Stock, as described  herein.  Dr. Lindsay A. Rosenwald,  the
President  and  sole  stockholder  of  PCAM,  is also  the  President  and  sole
stockholder of Paramount Capital,  Inc., the Company's financial advisor and the
placement  agent for the  Private  Placement.  In  connection  with the  Private
Placement,  Paramount  Capital,  Inc. and their designees received Unit Purchase
Warrants to purchase an aggregate of 40,395  shares of Series D Preferred  Stock
and


                                     - 26 -


<PAGE>

201,975  Class D Warrants as  compensation  for services as placement  agent and
financial advisor.  Paramount Capital, Inc. allocated to Mr. Weiss and an entity
of which Mr. Weiss is the managing member, Unit Purchase Warrants to purchase an
aggregate  of 5,934  shares  of Series D  Preferred  Stock  and  29,670  Class D
Warrants.

        In December 1992, the Company and Jagotec formed Genta Jago Technologies
B.V.  ("Genta  Jago"),  a 50/50  joint  venture  to  develop  and  commercialize
therapeutic products on a worldwide basis. In 1996, SkyePharma acquired Jagotec.
Michael  Weiss is a managing  director of Genta Jago.  Among other  things,  the
Company is required to provide loans to Genta Jago pursuant to a working capital
agreement which expires in October 1998. The loans are advanced up to a mutually
agreed upon  maximum  commitment  amount,  which  amount is  established  by the
parties on a periodic  basis.  As of December 31, 1997, the Company had advanced
working  capital  loans  of  approximately  $15,800,000  to Genta  Jago,  net of
principal repayments and credits,  which amount fully satisfied what the Company
believes is the loan commitment  established by the parties through December 31,
1997.  Such loans bear  interest  and are  payable in full in October  1998,  or
earlier in the event  certain  revenues  are  received  by Genta Jago from third
parties.  There can be no  assurance,  however,  that Genta Jago will obtain the
necessary financial resources to repay such loans to the Company.

        Under the terms of the joint venture, Genta Jago has contracted with the
Company to conduct  research and development and provide certain other services.
Revenues  associated  with providing such services,  totaling  $350,000 in 1997,
were recorded by the Company as related  party  contract  revenue.  Terms of the
arrangement also grant the Company an option to purchase  Jagotec's  interest in
Genta Jago exercisable from December 1998 through December 2000.


                                     - 27 -


<PAGE>

                                  PROPOSAL FIVE

                    ADOPTION OF THE 1998 STOCK INCENTIVE PLAN

                                       AND

                        GRANTS OF OPTIONS UNDER THE PLAN


        The Board of Directors believes that the Company's existing Stock Option
Plan  is  inadequate  to  provide  sufficient   incentives  for  the  successful
recruitment and retention of key personnel.  The Board of Directors has adopted,
and is submitting to the  stockholders  for approval,  the Company's  1998 Stock
Incentive Plan (the "1998 Plan"), the full text of which is set forth in Exhibit
D  hereto.  Directors,  officers  and other  employees  of the  Company  and its
subsidiaries,  as well as consultants to the Company and its  subsidiaries,  are
eligible to participate  under the 1998 Plan.  Stockholder  approval of Proposal
Five is necessary,  inter alia, to comply with the listing maintenance standards
of Nasdaq, to comply with the provisions of the  performance-based  compensation
exemption from the tax deduction limit imposed by Section 162(m) of the Internal
Revenue Code (the "Code") to the extent permitted by said provisions, as well as
to ensure that incentive stock options are available for issuance.



        The main features of the 1998 Plan are outlined  below,  but the outline
is qualified by reference to the complete text of the plan.



GENERAL

        As of May 28, 1998, the Company's Board of Directors adopted, subject to
stockholder approval,  the 1998 Plan. The 1998 Plan provides for the issuance of
authorized and unissued  shares of Common Stock,  treasury  shares and/or shares
acquired  by the  Company  for  purposes  of the 1998  Plan up to a  maximum  of
6,750,000  shares  (which  is  approximately  15%  of  the  Common  Stock  on  a
fully-diluted  basis,  excluding  options and warrants with an exercise price of
$2.00 or more);  provided,  however,  that such maximum  number of shares may be
increased at any time or from time to time,  at the  discretion  of the Board of
Directors,  by an aggregate amount up to the product of (x) 0.15 and (y) the sum
of (1) the difference between (A) the number of shares of Common Stock which may
be obtained upon conversion of the Series D Preferred Stock, after giving effect
to any  modification  in the conversion  price  effected by the  provision,  for
adjusting  (the "Reset") such  conversion  price upon the  occurrence of a Reset
Event,  of  the  fifth  paragraph  of  Subsection  4(a)  of the  Certificate  of
Designations  for the Series D Preferred Stock, as amended from time to time, or
any contractual  modification to such Reset (collectively,  the "Reset") and (B)
the number of shares of Common Stock  obtainable upon conversion of the Series D
Preferred Stock  immediately prior to such Reset and (2) the number of shares of
Common Stock which may be obtained  upon the  exercise of any Penalty  Warrants.
The total number of incentive stock options, however, which may be granted under
the 1998 Plan may not exceed 5,000,000 shares.  Generally,  shares subject to an
award that remain  unissued  upon  expiration or  cancellation  of the award are
available  for  other  awards  under  the  1998  Plan.  In the  event of a stock
dividend,  stock split, reverse stock split,  combination or reclassification of
the  Common  Stock or the  like,  the  Board of  Directors  or the  Compensation
Committee of the Board of Directors (the  "Committee") will equitably adjust the
aggregate  number of  shares  subject  to the 1998  Plan,  the  number of shares
subject to each  outstanding  award,  and the exercise price of each outstanding
option.

        Awards  under  the 1998  Plan  may be made in the form of (i)  incentive
stock options,  (ii)  non-qualified  stock options  (incentive and non-qualified
stock  options  are  collectively   referred  to  as  "options"),   (iii)  stock
appreciation  rights,  (iv) restricted  stock, (v) restricted stock units,  (vi)
dividend  equivalent  rights and (vii) other stock-based  awards.  Awards may be
made to such  directors,  officers  and other  employees  of the Company and its
subsidiaries (including prospective employees who become employees), and to such
consultants,  advisors and other independent  contractors of the Company and its
subsidiaries,  as the Committee  shall in its discretion  select  (collectively,
"key persons").


                                     - 28 -


<PAGE>

ADMINISTRATION

        The  1998  Plan  may be  administered  by the  Board  or the  Committee,
composed  of  not  fewer  than  two  directors.   To  the  extent  required  for
transactions  under the 1998 Plan to qualify for the exemptions  available under
Rule 16b-3 promulgated  under the 1934 Act ("Rule 16b-3"),  all actions relating
to awards to persons subject to Section 16 of the 1934 Act shall be taken by the
Board  unless  each  person  who  serves  on the  Committee  is a  "non-employee
director"  within  the  meaning  of Rule  16b-3 or such  actions  are taken by a
sub-committee  of the Committee (or the Board) comprised solely of "non-employee
directors".  To the extent required for compensation  realized from awards under
the Plan to be deductible by the Company pursuant to Section 162(m) of the Code,
the members of the Committee shall be "outside  directors" within the meaning of
Section  162(m).  The Board and Committee are authorized to construe,  interpret
and implement the provisions of the 1998 Plan, to select the key persons to whom
awards will be granted,  to determine  the terms and  provisions of such awards,
and to amend outstanding  awards.  The determinations of the Board and Committee
are made in their sole  discretion and are conclusive.  The Committee  presently
consists  of Glenn L.  Cooper,  M.D.,  Chairman,  Andrew J. Stein and Michael S.
Weiss. (As used herein, "Committee" refers to the Committee and/or the Board, as
appropriate).



GRANTS UNDER THE 1998 PLAN


        Stock Options

        Unless the Committee expressly provides otherwise, an option will become
exercisable as to 25% of the shares subject thereto on each of the first through
fourth anniversaries of the grant. The purchase price per share payable upon the
exercise of an option (the "option  exercise  price") will be established by the
Committee, provided that the option exercise price shall be no less than 100% of
the fair market value of a share of the Common Stock on the date of grant in the
case of an incentive stock option. However, to the extent required under Section
422 of the Code, an incentive  option granted to an individual  who, at the time
the option is granted, owns stock possessing more than 10% of the total combined
voting  power of all  classes  of stock of his  employer  corporation  or of its
parent or subsidiary must satisfy the following conditions: (a) at the time such
option is granted,  the option  exercise price shall be no less than 110% of the
fair  market  value of a share of the Common  Stock on the date of grant and (b)
the option by its terms is not  exercisable  after the  expiration of five years
from the date it is granted.  The option  exercise price is payable in cash, or,
with the consent of the Committee, by surrender of shares of Common Stock having
a fair  market  value  on the date of the  exercise  equal to part or all of the
option  exercise  price,  or by such other  payment  method as the Committee may
prescribe.


        Stock Appreciation Rights

        Stock  appreciation  rights may be granted in connection with all or any
part of, or independently of, any option granted under the 1998 Plan. Generally,
no stock  appreciation  right will be  exercisable  at a time when any option to
which it relates is not exercisable.  The grantee of a stock  appreciation right
has the right to surrender the stock  appreciation right and to receive from the
Company an amount  equal to the  aggregate  appreciation  (since the date of the
grant,  or over the option  exercise  price if the stock  appreciation  right is
granted in  connection  with an option) in the shares of Common Stock in respect
of which such stock  appreciation  right is being  exercised.  Payment  due upon
exercise  of a stock  appreciation  right may be in cash,  in Common  Stock,  or
partly in each, as determined by the Committee in its discretion.


        Individual Limitation on Stock Options and Stock Appreciation Rights

        The total number of shares of Common Stock with respect to which options
and stock  appreciation  rights may be granted  to any one  employee  during any
two-year period may not exceed 8,000,000.

        Restricted Stock

        The  Committee  may grant or sell  restricted  shares of Common Stock to
such key  persons,  in such  amounts,  and subject to such terms and  conditions
(which may depend upon or be related to performance  goals and other conditions)
as the Committee shall determine in its discretion.  Certificates for the shares
of  Common  Stock  covered  by a  restricted  stock  award  will  remain  in the
possession of the Company until such shares are free of restrictions. Subject to
the applicable  restrictions,  the grantee has the rights of a stockholder  with
respect to the restricted stock.



        Restricted Stock Units

        The Committee may grant restricted  stock units to such key persons,  in
such amounts,  and subject to such terms and  conditions as the Committee  shall
determine  in its  discretion.  Restricted  stock units are intended to give the
recipient the economic  equivalent of actual restricted  shares of stock,  while
postponing the tax consequences.


                                     - 29 -


<PAGE>

A  restricted  stock unit is an  unsecured  promise to transfer an  unrestricted
share of stock at a specified  future maturity date (which can be later than the
vesting  date at which the right to receive the shares  becomes  nonforfeitable)
selected  by the  recipient  of the  unit at the  time of  grant  or  subsequent
thereto.



        Dividend Equivalent Rights

        The  Committee  may  include  in any award a dividend  equivalent  right
entitling the recipient to receive amounts equal to the ordinary  dividends that
would have been paid, during the time such award is outstanding,  unexercised or
not vested,  on the shares of Common Stock  covered by such award if such shares
were then outstanding.



        Other Stock Based-Awards

        The 1998 Plan permits the  Committee to grant other stock based  awards,
such as  performance  shares or  unrestricted  stock,  subject to such terms and
conditions as the Committee deems appropriate.



TERMINATION OF EMPLOYMENT OR SERVICE



        Options and Stock Appreciation Rights

        Unless the  Committee  otherwise  specifies:  (i) all  options and stock
appreciation  rights not yet exercised shall  terminate upon  termination of the
grantee's  employment  or service by reason of  discharge  for cause;  (ii) if a
grantee's  employment  or service  terminates  for  reasons  other than cause or
death, the grantee's options and/or stock appreciation  rights generally will be
exercisable  for 90  days  (or one  year  if the  termination  is by  reason  of
disability)  after  termination  to the  extent  that they were  exercisable  at
termination,  but not after the  expiration  date of the  award;  and (iii) if a
grantee  dies  while  in  the   Company's   employ  or  service  or  during  the
aforementioned  post-employment  exercise period,  the grantee's  options and/or
stock appreciation  rights will, to the extent exercisable  immediately prior to
death,  generally  remain  exercisable for one year after the date of death, but
not after the expiration date of the award.



        Restricted Stock

        If a grantee's  employment or service  terminates  for any reason during
the 120 days  following the employee's  termination  date, the Company will have
the  right  to  require   forfeiture  of  restricted   shares  then  subject  to
restrictions on transfer in exchange for any amount paid by the grantee for such
shares.

        Right of Recapture

        If at any time within one year after the date of a  "realization  event"
(as defined in Section  2.10 of the 1998 Plan),  the grantee is  terminated  for
cause or engages in any activity  determined in the  discretion of the Committee
to be in competition  with any activity of the Company,  or otherwise  inimical,
contrary or harmful to the interests of the Company (including,  but not limited
to,  accepting  employment  with or serving as a  consultant,  adviser or in any
other  capacity to an entity that is in  competition  with or acting against the
interests  of the  Company),  then any gain  realized  by the  grantee  from the
realization  event shall be paid by the grantee to the Company.  Such gain shall
be  determined  as of the  date  of the  realization  event,  regardless  of any
subsequent  change  in the fair  market  value of a share of Common  Stock.  The
Company  shall have the right to offset such gain against any amounts  otherwise
owed to the grantee by the Company (whether as wages,  vacation pay, or pursuant
to any benefit plan or other compensatory arrangement).


OTHER FEATURES OF THE 1998 PLAN

        The  Committee  may  amend any  outstanding  award,  including,  without
limitation,  by amendment which would  accelerate the time or times at which the
award becomes  unrestricted  or may be  exercised,  or waive or amend any goals,
restrictions  or conditions on the award.  The Board of Directors  may,  without
stockholder approval, suspend, discontinue, revise or amend the 1998 Plan at any
time or from time to time; provided, however, that stockholder approval shall be
obtained  to the  extent  necessary  to  comply  with  Section  422 of the  Code
(relating to the grant of incentive  stock  options) and other  applicable  law.
Unless sooner  terminated by the Board of Directors,  the provisions of the 1998
Plan  respecting  the grant of incentive  stock options  shall  terminate on the
tenth  anniversary  of the adoption of the 1998 Plan by the Board of  Directors.
All awards  made under the 1998 Plan prior to its  termination  shall  remain in
effect until they are satisfied or terminated.

        In the  event of a change in  control  of the  Company  (as  defined  in
Section 3.7 of the 1998 Plan),  (i) any then  outstanding  stock option or stock
appreciation right will become fully vested and immediately exercisable upon the
subsequent  termination  of  employment  of the  grantee  by the  Company or its
successors  without  cause within one year of the change in control,  unless the
applicable plan agreement otherwise provides, and (ii) the Committee


                                     - 30 -


<PAGE>

in its discretion may amend any outstanding award, including by amendments which
advance  the  dates  upon  which  any  or all  outstanding  awards  of any  type
terminate. In the event of a proposed liquidation or dissolution of the Company,
outstanding  awards will terminate  immediately prior to the consummation of the
action, unless otherwise provided by the Committee,  which in its discretion may
accelerate  the date on which any award becomes fully vested and/or declare that
any award will  terminate  as of a specified  date.  In the event of a merger or
consolidation  of the  Company  with or into any other  corporation  or  entity,
outstanding  awards shall be assumed or an  equivalent  option or right shall be
substituted  by such  successor  corporation  or a parent or  subsidiary of such
successor corporation,  unless the Committee determines,  in the exercise of its
sole discretion, to accelerate the date on which an award becomes exercisable or
fully vested. In the absence of an assumption or substitution of awards,  awards
shall,  to the extent not exercised,  terminate as of the date of the closing of
the merger.



GRANT OF OPTIONS TO CEO

        Pursuant to the provisions of the Letter  Agreement  described under the
caption "Executive Compensation  --Compensation of President and Chief Executive
Officer," the Board of Directors, as of May 28, 1998 (the "Grant Date"), granted
to Kenneth  G.  Kasses,  Ph.D.,  the  Company's  President  and Chief  Executive
Officer,  subject to stockholder  approval of this Proposal Five, a stock option
(the "Kasses Option") to purchase,  at an initial exercise price of $0.94375 per
share,  2,236,263 shares of Common Stock, having a market value of approximately
$1,747,080  as of  June  17,  1998  and  representing  approximately  5% of  the
Fairly-Diluted  Common Stock (as defined below) as of the Grant Date,  excluding
Penalty Warrants.  "Fairly-Diluted  Common Stock" means, as of a specified date,
the  number of shares of Common  Stock that  would be  outstanding  on such date
assuming:  (i) the  conversion  into Common Stock on such date of all  preferred
stock of the Company  outstanding on the Grant Date or issuable upon exercise of
warrants  outstanding  on the Grant Date;  and (ii) the exercise on such date of
all  warrants  of the  Company  outstanding  on the Grant Date or  contractually
required to be issued  pursuant to an agreement in effect on the Grant Date,  in
each case having an exercise  price per share of Common Stock of less than $2.00
on the Grant Date,  including,  but not limited to, Penalty Warrants.  As of May
28, 1998, there were 44,725,266 shares of Fairly-Diluted Common Stock (exclusive
of any Penalty Warrants which may be issued).  The exercise price and the number
of shares  subject to the Kasses  Option are subject to adjustment if the number
of shares of  Fairly-Diluted  Common Stock on February 26, 1999 (the "Adjustment
Date") is other than 44,725,266  shares (subject to proportional  adjustment for
any stock split or reverse  stock split of the Common  Stock) as a result of any
issuance of Penalty Warrants or alteration of the conversion price of the Series
D Preferred Stock pursuant to the Reset or any contractual  modification to such
Reset (such Reset, and, if contractually  modified by at least a majority of the
holders of the Series D Preferred  Stock, as so modified,  the "Series D Reset")
occurring prior to the Adjustment Date (the "Covered Events"), in which case the
Kasses  Option  shall  automatically  be  adjusted:  (x) to adjust the number of
shares of Common Stock covered to the extent  necessary to equal the sum of: (a)
2,236,263  shares of Common Stock  (subject to  proportional  adjustment for any
stock  split or  reverse  stock  split of the Common  Stock);  and (b) 5% of any
additional shares of Fairly-Diluted  Common Stock as of the Adjustment Date that
are  attributable to Covered Events (subject to proportional  adjustment for any
stock split or reverse stock split of the Common  Stock);  and (y) to adjust the
exercise  price so that the exercise  price per share is equal to the  per-share
conversion price of the Series D Preferred Stock  immediately after the Series D
Reset.  See  "Proposal  One:  Approval of Reverse  Stock Splits of the Company's
Outstanding  Common  Stock"  for a  description  of the  Series D Reset  and the
Penalty  Warrants.  The Kasses Option becomes  exercisable  in 16  substantially
equal  installments  on the last day of each  calendar  quarter after October 1,
1997, provided that adjustments to the number of options as provided above shall
be prorated  over the remaining  quarterly  periods  after the  adjustment.  The
Kasses Option expires on the tenth anniversary of the Grant Date; provided that,
if earlier, the Kasses Option shall expire one year after the termination of Dr.
Kasses' employment with the Company.



TAX CONSEQUENCES

        The following  description of the tax  consequences  of awards under the
1998 Plan is based on present  Federal  tax laws,  and does not  purport to be a
complete description of the tax consequences of the 1998 Plan.

        There are generally no Federal tax  consequences  either to the optionee
or to the Company upon the grant of a stock option.  On exercise of an incentive
stock option, the optionee will not realize any income, and the


                                     - 31 -


<PAGE>

Company  will not be entitled to a deduction  for tax  purposes,  although  such
exercise  may give rise to  liability  for the  optionee  under the  alternative
minimum tax provisions of the Code.  However, if the optionee disposes of shares
acquired upon exercise of an incentive stock option within two years of the date
of grant  or one  year of the date of  exercise,  the  optionee  will  recognize
compensation  income,  and the Company  will be  entitled to a deduction  in the
amount of the excess of the fair market  value of the shares of Common  Stock on
the date of exercise  over the option  exercise  price (or the gain on sale,  if
less);  the  remainder  of any gain to the  optionee  will be treated as capital
gain. On exercise of a non-qualified  stock option, the amount by which the fair
market  value of the Common  Stock on the date of  exercise  exceeds  the option
exercise price will generally be taxable to the optionee as compensation  income
and will generally be deductible for tax purposes by the Company.

        The grant of a stock  appreciation  right or restricted stock unit award
will not result in income for the grantee or in a tax deduction for the Company.
Upon the settlement of such a right or award,  the grantee will include in gross
income an amount  equal to the fair market  value of any shares of Common  Stock
and/or any cash received, and the Company will be entitled to a tax deduction in
the same amount.  An award of restricted  shares of Common Stock will not result
in income for the grantee or in a tax  deduction for the Company until such time
as the shares are no longer  subject to  forfeiture  unless the  grantee  elects
otherwise.  At that time, the grantee  generally will include in gross income an
amount  equal to the fair  market  value of the shares  less any amount paid for
them, and the Company will be entitled to a tax deduction in the same amount.



LIMITATIONS ON THE COMPANY'S COMPENSATION DEDUCTION

        Section  162(m) of the Code limits the  deduction  which the Company may
take for otherwise deductible compensation payable to certain executive officers
to the extent that the yearly  compensation  paid to such officers  exceeds $1.0
million,  unless such compensation meets certain criteria.  The Company believes
that  compensation  realized  from stock options and stock  appreciation  rights
granted under the 1998 Plan generally will satisfy the  requirements  of Section
162(m) of the Code if the options or stock appreciation  rights are granted by a
committee  of "outside  directors"  (as defined  under  Section  162(m)) and are
granted at fair market value;  however,  there is no assurance  that such awards
will satisfy such requirements. In addition, because other awards under the 1998
Plan will generally not meet the requirements of Section 162(m) of the Code, the
deduction attributable to any compensation realized under any such awards to the
affected executive  officers may be limited.  The Kasses Option does not satisfy
the requirements of Section 162(m) of the Code.



        THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL FIVE.

Approval of Proposal Five will require the affirmative vote of a majority of the
aggregate  voting  power of the shares of Common  Stock and  Series D  Preferred
Stock present in person or  represented  by proxy,  voting  together as a single
class.


                                     - 32 -


<PAGE>

                                  PROPOSAL SIX



         ADOPTION OF THE NON-EMPLOYEE DIRECTORS' 1998 STOCK OPTION PLAN

                                       AND

                        GRANTS OF OPTIONS UNDER THE PLAN



        The  Non-Employee  Directors'  1998 Stock  Option Plan (the  "Directors'
Plan") was  adopted by the Board of  Directors  as of May 28,  1998,  subject to
approval by the Company's stockholders. The purpose of the Directors' Plan is to
provide an incentive  to the  Company's  non-employee  directors to serve on the
Board  of  Directors  and  to  maintain  and  enhance  the  Company's  long-term
performance.  Stockholder approval of Proposal Six is necessary,  inter alia, to
comply with the listing maintenance standards of Nasdaq.

        The  following  summary of the main features of the  Directors'  Plan is
qualified by reference  to the complete  text of the plan,  which is attached as
Exhibit E hereto.



GENERAL

        The Directors' Plan provides for the issuance of authorized and unissued
shares of Common Stock,  treasury  shares and/or shares  acquired by the Company
for purposes of the Directors'  Plan up to a maximum of 3,000,000  shares (which
is  approximately  6.7% of the  Fairly-Diluted  Common Stock as of May 28, 1998)
plus the number of shares  underlying  the  options  referred to below under the
caption "Initial Grant of Options to Present Non-Employee Directors." Generally,
shares subject to an option that remain unissued upon expiration or cancellation
of the option are available for other options under the Directors'  Plan. In the
event  of any  change  in the  Common  Stock  by  reason  of a  stock  dividend,
recapitalization, merger, consolidation or the like, the Board of Directors will
adjust the number and kind of shares  issuable,  the number of shares subject to
options then  outstanding or subsequently  granted under the Directors' Plan and
the exercise price of such options.



INITIAL GRANTS OF OPTIONS TO PRESENT NON-EMPLOYEE DIRECTORS

        Pursuant to the Directors'  Plan, as of May 28, 1998 (the "Grant Date"),
the Board of  Directors  granted to each  non-employee  director of the Company,
subject to stockholder  approval of this Proposal Six, stock options to purchase
the  following  respective  numbers  of  shares of  Common  Stock at an  initial
exercise price of $0.94375 per share,  subject to adjustment as described below,
representing an aggregate of approximately 4% of the Fairly-Diluted Common Stock
as of May 28, 1998 (the "Grant Date"): Donald G. Drapkin,  675,000 shares; Glenn
L. Cooper,  M.D. and Bobby W. Sandage,  Jr.,  Ph.D.,  337,500  shares each;  and
Lawrence J. Kessel, M.D., Peter Salomon, M.D., Andrew J. Stein, Harlan J. Wakoff
and Michael S. Weiss,  75,000  shares  each.  The  exercise  price and number of
shares  underlying  such stock  options  shall be subject to  adjustment  if the
number of shares of  Fairly-Diluted  Common Stock as of the  Adjustment  Date is
other than 44,725,266  shares (subject to proportional  adjustment for any stock
split or reverse  stock  split of the  Common  Stock) as a result of any and all
Covered Events  occurring prior to such  Adjustment  Date, in which case (x) the
number of shares of Common Stock covered by the stock option shall increase by a
number of shares equal to the following respective  percentages of the number of
shares of  Fairly-Diluted  Common Stock as of the  Adjustment  Date in excess of
44,725,266 that are  attributable to Covered  Events:  Donald G. Drapkin,  1.5%;
Glenn L. Cooper, M.D. and Bobby W. Sandage,  Jr., Ph.D., .75% each; and Lawrence
J. Kessel,  M.D.,  Peter Salomon,  M.D.,  Andrew J. Stein,  Harlan J. Wakoff and
Michael S. Weiss,  .167% each,  and (y) the  per-share  exercise  price shall be
adjusted  to  equal  the  conversion  price  of the  Series  D  Preferred  Stock
immediately after the Series D Reset.

        Each of the options  described above has a term of ten years and becomes
exercisable  in 16  substantially  equal  installments  on the  last day of each
calendar  quarter after October 1, 1997 provided that  adjustments to the number
of options as  provided  above shall be prorated  over the  remaining  quarterly
periods after the adjustment.


                                     - 33 -


<PAGE>

In the event of a change in control of the Company  (as defined in Section  8(d)
of the Directors'  Plan),  the options  described above will become fully vested
and immediately exercisable (i) upon the termination of the director's status as
an Eligible  Director  under the  Directors'  Plan as a result of the removal of
such person from the Board (other than for cause) by  shareholder  action within
one year of such change in control or (ii) in the case of any liquidation of the
Company or sale or  disposition  of all or  substantially  all of the  Company's
assets, immediately upon the consummation thereof.



ANNUAL OPTION GRANTS

        The  Directors'  Plan  provides  for grants,  at each annual  meeting of
stockholders  of the  Company  commencing  with the Annual  Meeting in 1999,  of
nonqualified  stock  options to purchase  50,000  shares of Common Stock to each
non-employee  director,  excluding  any director  who is then  receiving a grant
under any other  equity-based  plan or  arrangement of the Company in connection
with his or her  initial  election  or  appointment  to the Board of  Directors,
provided that the director has served on the Board of Directors for at least six
months prior to the date of the annual meeting (such annual options, the "Annual
Options"). Each Annual Option granted under the Directors' Plan will have a term
of ten  years  and will  become  exercisable  in full on the date of the  annual
meeting next  following  the date of grant.  The  exercise  price of each Annual
Option granted under the  Directors'  Plan will equal the fair market value of a
share of Common Stock on the date of the relevant Annual Meeting.



TERMINATION OF SERVICE

        If a  non-employee  director's  service on the Board  terminates for any
reason other than death or disability, options granted under the Directors' Plan
will be  exercisable  for six months after  termination  to the extent they were
exercisable at the time of termination, but not after the expiration date of the
option.  If a director  dies or becomes  disabled  while serving on the Board or
during the  aforementioned  post-service  exercise  period,  the options granted
under the Directors' Plan will, to the extent  exercisable  immediately prior to
death or disability,  remain exercisable for one year after the date of death or
disability, but not after the expiration date of the option.



OTHER FEATURES OF THE DIRECTORS' PLAN

        In the event of a merger or  consolidation  of the Company  with or into
any other  corporation  or  entity,  outstanding  awards  shall be assumed or an
equivalent option or right shall be substituted by such successor corporation or
a parent or subsidiary of such successor corporation.

        The  Board may  amend  the  Directors'  Plan at any time or from time to
time; provided, that no amendment may impair any material rights or increase any
material  obligations  under  any  outstanding  option  without  the  optionee's
consent.  Stockholder  approval of any amendment shall be obtained to the extent
necessary to comply with any applicable law, rule or regulation.

        Unless  sooner  terminated  by  the  Board,  the  Directors'  Plan  will
terminate on the date when no more shares are available for issuance thereunder.
All options  granted under the  Directors'  Plan prior to its  termination  will
continue in effect until exercised or terminated.



FEDERAL INCOME TAX CONSEQUENCES

        The following  description of the tax  consequences of awards of options
under the  Directors'  Plan is based on present  Federal tax laws,  and does not
purport to be a complete  description of the tax  consequences of the Directors'
Plan.

        There are generally no federal tax  consequences  either to the optionee
or  to  the  Company  upon  the  grant  of a  stock  option.  On  exercise  of a
non-qualified  stock  option,  the amount by which the fair market  value of the
Common  Stock on the date of  exercise  exceeds the option  exercise  price will
generally be taxable to the optionee as  compensation  income and will generally
be deductible for tax purposes by the Company.


                                     - 34 -


<PAGE>

        THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL SIX.

Approval of Proposal Six will require the affirmative  vote of a majority of the
aggregate  voting  power of the shares of Common  Stock and  Series D  Preferred
Stock present in person or  represented  by proxy,  voting  together as a single
class.


                                     - 35 -


<PAGE>

                              STOCKHOLDER PROPOSALS


        Proposals  of  stockholders  intended to be presented at the 1999 annual
meeting of  stockholders  of the Company  must be received by the Company at the
offices of the Company,  at 3550 General  Atomics Court,  San Diego,  California
92121 no later than  February  22,  1999 [120 days before the date of this proxy
statement plus one year] in order to be included in the proxy statement and form
of proxy relating to such annual meeting.



             SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE


        Section  16(a) of the 1934 Act, as amended,  requires the  directors and
executive officers of the Company and persons who beneficially own more than ten
percent of the Company's Common Stock (collectively, the "Reporting Persons") to
report their ownership of and  transactions in the Company's Common Stock to the
SEC.  Copies of these  reports are also  required to be supplied to the Company.
The Company  believes,  upon a review of the copies of such reports  received by
the Company,  written representations  furnished by the Reporting Persons to the
Company  and SEC  filings,  that  during the year ended  December  31,  1997 the
Reporting   Persons  complied  with  all  applicable   Section  16(a)  reporting
requirements,  except as follows:  Mr.  Michael Weiss did not file a Form 3 on a
timely basis to report his appointment as a director of the Company.



                                  OTHER MATTERS


        The Board of Directors knows of no other business that will be presented
at the Annual  Meeting.  If any other  business is properly  brought  before the
Annual  Meeting,  it is intended that proxies in the enclosed form will be voted
in accordance with the judgment of the persons voting the proxies.



        Whether  you intend to be present at the Annual  Meeting or not, we urge
you to return your signed proxy promptly.



                                            By order of the Board of Directors,




                                        /s/ Kenneth G. Kasses, Ph.D.
                                        ----------------------------
                                            Kenneth G. Kasses, Ph.D.
                                            President and
                                            Chief Executive Officer

Dated: June 22, 1998


                                     - 36 -


<PAGE>

EXHIBIT A

                            CERTIFICATE OF AMENDMENT
                                       OF
                      RESTATED CERTIFICATE OF INCORPORATION
                                       OF
                               GENTA INCORPORATED

      GENTA INCORPORATED, a corporation organized and existing under and by
virtue of the General Corporation Law of the State of Delaware,

        DOES HEREBY CERTIFY:

        FIRST:   That  at  a  meeting  of  the  Board  of   Directors  of  Genta
Incorporated, resolutions were duly adopted setting forth proposed amendments of
the Restated Certificate of Incorporation of the corporation, and declaring that
such amendments are advisable and that such amendment should be submitted to the
stockholders of the corporation for approval.  The resolutions setting forth the
proposed amendments are as follows:

               A.     Two-for-Three Reverse Stock Split.

        RESOLVED,   that,   prior  to  the  Company's  next  Annual  Meeting  of
Stockholders  following the 1998 Annual Meeting,  on the condition that no other
amendment to the Company's Restated Certificate of Incorporation shall have been
filed  subsequent to July 14, 1998 effecting a reverse stock split of the Common
Stock,  Article IV of the Company's  Restated  Certificate of  Incorporation  be
amended by addition of the following provision:

        Simultaneously with the effective date of this amendment (the "Effective
        Date"),  each share of the Company's  Common Stock,  par value $.001 per
        share,  issued and outstanding  immediately  prior to the Effective Date
        (the "Old Common Stock") shall  automatically  and without any action on
        the part of the  holder  thereof be  reclassified  as and  changed  into
        two-thirds  (2/3) of a share of the Company's  Common  Stock,  par value
        $.001 per share (the "New Common  Stock"),  subject to the  treatment of
        fractional  share  interests  as  described  below.  Each  holder  of  a
        certificate or  certificates  which  immediately  prior to the Effective
        Date  represented  outstanding  shares  of Old  Common  Stock  (the "Old
        Certificates")  shall be entitled to receive upon  surrender of such Old
        Certificates  to  the  Company's  Transfer  Agent  for  cancellation,  a
        certificate or certificates  (the "New  Certificate")  representing  the
        number of whole  shares of the New Common Stock  determined  by dividing
        the  number  of  shares  of Old  Common  Stock  represented  by such Old
        Certificate(s)  immediately  prior to the time  this  amendment  becomes
        effective by three halves (3/2) and rounding  such number up to the next
        whole integer. From and after the Effective Date, Old Certificates shall
        represent  only the right to receive  New  Certificates  pursuant to the
        provisions  hereof.  No  certificates or scrip  representing  fractional
        share interests in New Common Stock will be issued. If more than one Old
        Certificate shall be surrendered at one time for the account of the same
        stockholder, the number of full shares of New Common Stock for which New
        Certificates  shall be  issued  shall be  computed  on the  basis of the
        aggregate  number  of  shares  represented  by the Old  Certificates  so
        surrendered.  In the event that the Company's  Transfer Agent determines
        that a holder of Old  Certificates has not tendered all his certificates
        for  exchange,  the Transfer  Agent shall carry  forward any  fractional
        share until all  certificates  of that holder  have been  presented  for
        exchange such that rounding up for  fractional  shares to any one person
        shall not exceed one share.  If any New Certificate is to be issued in a
        name  other  than that in which  the Old  Certificates  surrendered  for
        exchange  are  issued,  the Old  Certificates  so  surrendered  shall be
        properly  endorsed and  otherwise in proper form for  transfer,  and the
        person or persons  requesting  such  exchange  shall affix any requisite
        stock  transfer  tax  stamps  to the Old  Certificates  surrendered,  or
        provide funds for their  purchase,  or establish to the  satisfaction of
        the Transfer  Agent that such taxes are not payable.  From and after the
        Effective  Date the amount of capital  represented  by the shares of the
        New  Common  Stock into which and for which the shares of the Old Common
        Stock are  reclassified  under the terms hereof shall be the same as the
        amount of capital represented by the shares


                                      - 1 -


<PAGE>

        of Old  Common  Stock  so  reclassified,  until  thereafter  reduced  or
        increased in accordance with applicable law.

        FURTHER RESOLVED,  that at any time prior to the filing of the foregoing
amendment to the Company's  Restated  Certificate of  Incorporation  effecting a
two-for-three Reverse Stock Split, notwithstanding authorization of the proposed
amendment by the stockholders of the Company, the board of directors may abandon
such proposed amendment without further action by the stockholders.

        B.     One-for-Two Reverse Stock Split.

        RESOLVED,   that,   prior  to  the  Company's  next  Annual  Meeting  of
Stockholders  following the 1998 Annual Meeting,  on the condition that no other
amendment to the Company's Restated Certificate of Incorporation shall have been
filed  subsequent to July 14, 1998 effecting a reverse stock split of the Common
Stock,  Article IV of the Company's  Restated  Certificate of  Incorporation  be
amended by addition of the following provision:

        Simultaneously with the effective date of this amendment (the "Effective
        Date"),  each share of the Company's  Common Stock,  par value $.001 per
        share,  issued and outstanding  immediately  prior to the Effective Date
        (the "Old Common Stock") shall  automatically  and without any action on
        the part of the holder thereof be  reclassified  as and changed into one
        half (1/2) of a share of the Company's Common Stock, par value $.001 per
        share (the "New Common  Stock"),  subject to the treatment of fractional
        share  interests as described  below.  Each holder of a  certificate  or
        certificates  which  immediately prior to the Effective Date represented
        outstanding shares of Old Common Stock (the "Old Certificates") shall be
        entitled  to receive  upon  surrender  of such Old  Certificates  to the
        Company's Transfer Agent for cancellation, a certificate or certificates
        (the "New  Certificate")  representing the number of whole shares of the
        New Common  Stock  determined  by  dividing  the number of shares of Old
        Common Stock represented by such Old Certificate(s) immediately prior to
        the time this amendment  becomes  effective by two (2) and rounding such
        number up to the next whole integer.  From and after the Effective Date,
        Old  Certificates   shall  represent  only  the  right  to  receive  New
        Certificates pursuant to the provisions hereof. No certificates or scrip
        representing  fractional  share  interests  in New Common  Stock will be
        issued.  If more than one Old  Certificate  shall be  surrendered at one
        time for the account of the same stockholder,  the number of full shares
        of New Common Stock for which New Certificates  shall be issued shall be
        computed on the basis of the aggregate  number of shares  represented by
        the Old  Certificates  so  surrendered.  In the event that the Company's
        Transfer  Agent  determines  that a holder of Old  Certificates  has not
        tendered all his  certificates  for exchange,  the Transfer  Agent shall
        carry forward any fractional share until all certificates of that holder
        have been  presented for exchange  such that rounding up for  fractional
        shares  to any  one  person  shall  not  exceed  one  share.  If any New
        Certificate  is to be issued in a name  other than that in which the Old
        Certificates  surrendered for exchange are issued,  the Old Certificates
        so surrendered  shall be properly  endorsed and otherwise in proper form
        for transfer,  and the person or persons  requesting such exchange shall
        affix any requisite  stock  transfer tax stamps to the Old  Certificates
        surrendered,  or provide funds for their  purchase,  or establish to the
        satisfaction of the Transfer Agent that such taxes are not payable. From
        and after the Effective  Date the amount of capital  represented  by the
        shares of the New  Common  Stock  into which and for which the shares of
        the Old Common  Stock are  reclassified  under the terms hereof shall be
        the same as the  amount  of  capital  represented  by the  shares of Old
        Common Stock so reclassified,  until thereafter  reduced or increased in
        accordance with applicable law.

        FURTHER RESOLVED,  that at any time prior to the filing of the foregoing
amendment to the Company's  Restated  Certificate of  Incorporation  effecting a
one-for-two Reverse Stock Split,  notwithstanding  authorization of the proposed
amendment by the stockholders of the Company, the board of directors may abandon
such proposed amendment without further action by the stockholders.

        C.     Two-for-Five Reverse Stock Split.

        RESOLVED,   that,   prior  to  the  Company's  next  Annual  Meeting  of
Stockholders  following the 1998 Annual Meeting,  on the condition that no other
amendment to the Company's Restated Certificate of Incorporation shall


                                      - 2 -


<PAGE>

have been filed  subsequent to July 14, 1998  effecting a reverse stock split of
the  Common  Stock,   Article  IV  of  the  Company's  Restated  Certificate  of
Incorporation be amended by addition of the following provision:

        Simultaneously with the effective date of this amendment (the "Effective
        Date"),  each share of the Company's  Common Stock,  par value $.001 per
        share,  issued and outstanding  immediately  prior to the Effective Date
        (the "Old Common Stock") shall  automatically  and without any action on
        the part of the  holder  thereof be  reclassified  as and  changed  into
        two-fifths  (2/5) of a share of the Company's  Common  Stock,  par value
        $.001 per share (the "New Common  Stock"),  subject to the  treatment of
        fractional  share  interests  as  described  below.  Each  holder  of  a
        certificate or  certificates  which  immediately  prior to the Effective
        Date  represented  outstanding  shares  of Old  Common  Stock  (the "Old
        Certificates")  shall be entitled to receive upon  surrender of such Old
        Certificates  to  the  Company's  Transfer  Agent  for  cancellation,  a
        certificate or certificates  (the "New  Certificate")  representing  the
        number of whole  shares of the New Common Stock  determined  by dividing
        the  number  of  shares  of Old  Common  Stock  represented  by such Old
        Certificate(s)  immediately  prior to the time  this  amendment  becomes
        effective by five halves  (5/2) and rounding  such number up to the next
        whole integer. From and after the Effective Date, Old Certificates shall
        represent  only the right to receive  New  Certificates  pursuant to the
        provisions  hereof.  No  certificates or scrip  representing  fractional
        share interests in New Common Stock will be issued. If more than one Old
        Certificate shall be surrendered at one time for the account of the same
        stockholder, the number of full shares of New Common Stock for which New
        Certificates  shall be  issued  shall be  computed  on the  basis of the
        aggregate  number  of  shares  represented  by the Old  Certificates  so
        surrendered.  In the event that the Company's  Transfer Agent determines
        that a holder of Old  Certificates has not tendered all his certificates
        for  exchange,  the Transfer  Agent shall carry  forward any  fractional
        share until all  certificates  of that holder  have been  presented  for
        exchange such that rounding up for  fractional  shares to any one person
        shall not exceed one share.  If any New Certificate is to be issued in a
        name  other  than that in which  the Old  Certificates  surrendered  for
        exchange  are  issued,  the Old  Certificates  so  surrendered  shall be
        properly  endorsed and  otherwise in proper form for  transfer,  and the
        person or persons  requesting  such  exchange  shall affix any requisite
        stock  transfer  tax  stamps  to the Old  Certificates  surrendered,  or
        provide funds for their  purchase,  or establish to the  satisfaction of
        the Transfer  Agent that such taxes are not payable.  From and after the
        Effective  Date the amount of capital  represented  by the shares of the
        New  Common  Stock into which and for which the shares of the Old Common
        Stock are  reclassified  under the terms hereof shall be the same as the
        amount of  capital  represented  by the  shares of Old  Common  Stock so
        reclassified,  until thereafter  reduced or increased in accordance with
        applicable law.

        FURTHER RESOLVED,  that at any time prior to the filing of the foregoing
amendment to the Company's  Restated  Certificate of  Incorporation  effecting a
two-for-five Reverse Stock Split, notwithstanding  authorization of the proposed
amendment by the stockholders of the Company, the board of directors may abandon
such proposed amendment without further action by the stockholders.


                                      - 3 -


<PAGE>

        D.     One-for-Three Reverse Stock Split.

        RESOLVED,   that,   prior  to  the  Company's  next  Annual  Meeting  of
Stockholders  following the 1998 Annual Meeting,  on the condition that no other
amendment to the Company's Restated Certificate of Incorporation shall have been
filed  subsequent to July 14, 1998 effecting a reverse stock split of the Common
Stock,  Article IV of the Company's  Restated  Certificate of  Incorporation  be
amended by addition of the following provision:

        Simultaneously with the effective date of this amendment (the "Effective
        Date"),  each share of the Company's  Common Stock,  par value $.001 per
        share,  issued and outstanding  immediately  prior to the Effective Date
        (the "Old Common Stock") shall  automatically  and without any action on
        the part of the  holder  thereof be  reclassified  as and  changed  into
        one-third  (1/3) of a share of the  Company's  Common  Stock,  par value
        $.001 per share (the "New Common  Stock"),  subject to the  treatment of
        fractional  share  interests  as  described  below.  Each  holder  of  a
        certificate or  certificates  which  immediately  prior to the Effective
        Date  represented  outstanding  shares  of Old  Common  Stock  (the "Old
        Certificates")  shall be entitled to receive upon  surrender of such Old
        Certificates  to  the  Company's  Transfer  Agent  for  cancellation,  a
        certificate or certificates  (the "New  Certificate")  representing  the
        number of whole  shares of the New Common Stock  determined  by dividing
        the  number  of  shares  of Old  Common  Stock  represented  by such Old
        Certificate(s)  immediately  prior to the time  this  amendment  becomes
        effective  by three (3) and  rounding  such  number up to the next whole
        integer.  From and after the  Effective  Date,  Old  Certificates  shall
        represent  only the right to receive  New  Certificates  pursuant to the
        provisions  hereof.  No  certificates or scrip  representing  fractional
        share interests in New Common Stock will be issued. If more than one Old
        Certificate shall be surrendered at one time for the account of the same
        stockholder, the number of full shares of New Common Stock for which New
        Certificates  shall be  issued  shall be  computed  on the  basis of the
        aggregate  number  of  shares  represented  by the Old  Certificates  so
        surrendered.  In the event that the Company's  Transfer Agent determines
        that a holder of Old  Certificates has not tendered all his certificates
        for  exchange,  the Transfer  Agent shall carry  forward any  fractional
        share until all  certificates  of that holder  have been  presented  for
        exchange such that rounding up for  fractional  shares to any one person
        shall not exceed one share.  If any New Certificate is to be issued in a
        name  other  than that in which  the Old  Certificates  surrendered  for
        exchange  are  issued,  the Old  Certificates  so  surrendered  shall be
        properly  endorsed and  otherwise in proper form for  transfer,  and the
        person or persons  requesting  such  exchange  shall affix any requisite
        stock  transfer  tax  stamps  to the Old  Certificates  surrendered,  or
        provide funds for their  purchase,  or establish to the  satisfaction of
        the Transfer  Agent that such taxes are not payable.  From and after the
        Effective  Date the amount of capital  represented  by the shares of the
        New  Common  Stock into which and for which the shares of the Old Common
        Stock are  reclassified  under the terms hereof shall be the same as the
        amount of  capital  represented  by the  shares of Old  Common  Stock so
        reclassified,  until thereafter  reduced or increased in accordance with
        applicable law.

        FURTHER RESOLVED,  that at any time prior to the filing of the foregoing
amendment to the Company's  Restated  Certificate of  Incorporation  effecting a
one-for-three Reverse Stock Split, notwithstanding authorization of the proposed
amendment by the stockholders of the Company, the board of directors may abandon
such proposed amendment without further action by the stockholders.

        E.     One-for-Four Reverse Stock Split.

        RESOLVED,   that,   prior  to  the  Company's  next  Annual  Meeting  of
Stockholders  following the 1998 Annual Meeting,  on the condition that no other
amendment to the Company's Restated Certificate of Incorporation shall have been
filed  subsequent to July 14, 1998 effecting a reverse stock split of the Common
Stock,  Article IV of the Company's  Restated  Certificate of  Incorporation  be
amended by addition of the following provision:

        Simultaneously with the effective date of this amendment (the "Effective
        Date"),  each share of the Company's  Common Stock,  par value $.001 per
        share,  issued and outstanding  immediately  prior to the Effective Date
        (the "Old Common Stock") shall  automatically  and without any action on
        the part of the holder thereof be  reclassified  as and changed into one
        quarter (1/4) of a share of the Company's  Common Stock, par value $.001
        per  share  (the  "New  Common  Stock"),  subject  to the  treatment  of
        fractional share


                                      - 4 -


<PAGE>

        interests  as  described   below.   Each  holder  of  a  certificate  or
        certificates  which  immediately prior to the Effective Date represented
        outstanding shares of Old Common Stock (the "Old Certificates") shall be
        entitled  to receive  upon  surrender  of such Old  Certificates  to the
        Company's Transfer Agent for cancellation, a certificate or certificates
        (the "New  Certificate")  representing the number of whole shares of the
        New Common  Stock  determined  by  dividing  the number of shares of Old
        Common Stock represented by such Old Certificate(s) immediately prior to
        the time this amendment  becomes effective by four (4) and rounding such
        number up to the next whole integer.  From and after the Effective Date,
        Old  Certificates   shall  represent  only  the  right  to  receive  New
        Certificates pursuant to the provisions hereof. No certificates or scrip
        representing  fractional  share  interests  in New Common  Stock will be
        issued.  If more than one Old  Certificate  shall be  surrendered at one
        time for the account of the same stockholder,  the number of full shares
        of New Common Stock for which New Certificates  shall be issued shall be
        computed on the basis of the aggregate  number of shares  represented by
        the Old  Certificates  so  surrendered.  In the event that the Company's
        Transfer  Agent  determines  that a holder of Old  Certificates  has not
        tendered all his  certificates  for exchange,  the Transfer  Agent shall
        carry forward any fractional share until all certificates of that holder
        have been  presented for exchange  such that rounding up for  fractional
        shares  to any  one  person  shall  not  exceed  one  share.  If any New
        Certificate  is to be issued in a name  other than that in which the Old
        Certificates  surrendered for exchange are issued,  the Old Certificates
        so surrendered  shall be properly  endorsed and otherwise in proper form
        for transfer,  and the person or persons  requesting such exchange shall
        affix any requisite  stock  transfer tax stamps to the Old  Certificates
        surrendered,  or provide funds for their  purchase,  or establish to the
        satisfaction of the Transfer Agent that such taxes are not payable. From
        and after the Effective  Date the amount of capital  represented  by the
        shares of the New  Common  Stock  into which and for which the shares of
        the Old Common  Stock are  reclassified  under the terms hereof shall be
        the same as the  amount  of  capital  represented  by the  shares of Old
        Common Stock so reclassified,  until thereafter  reduced or increased in
        accordance with applicable law.

        FURTHER RESOLVED,  that at any time prior to the filing of the foregoing
amendment to the Company's  Restated  Certificate of  Incorporation  effecting a
one-for-four Reverse Stock Split, notwithstanding  authorization of the proposed
amendment by the stockholders of the Company, the board of directors may abandon
such proposed amendment without further action by the stockholders.

        F.     One-for-Five Reverse Stock Split.

        RESOLVED,   that,   prior  to  the  Company's  next  Annual  Meeting  of
Stockholders  following the 1998 Annual Meeting,  on the condition that no other
amendment to the Company's Restated Certificate of Incorporation shall have been
filed  subsequent to July 14, 1998 effecting a reverse stock split of the Common
Stock,  Article IV of the Company's  Restated  Certificate of  Incorporation  be
amended by addition of the following provision:

        Simultaneously with the effective date of this amendment (the "Effective
        Date"),  each share of the Company's  Common Stock,  par value $.001 per
        share,  issued and outstanding  immediately  prior to the Effective Date
        (the "Old Common Stock") shall  automatically  and without any action on
        the part of the holder thereof be  reclassified  as and changed into one
        fifth (1/5) of a share of the Company's  Common  Stock,  par value $.001
        per  share  (the  "New  Common  Stock"),  subject  to the  treatment  of
        fractional  share  interests  as  described  below.  Each  holder  of  a
        certificate or  certificates  which  immediately  prior to the Effective
        Date  represented  outstanding  shares  of Old  Common  Stock  (the "Old
        Certificates")  shall be entitled to receive upon  surrender of such Old
        Certificates  to  the  Company's  Transfer  Agent  for  cancellation,  a
        certificate or certificates  (the "New  Certificate")  representing  the
        number of whole  shares of the New Common Stock  determined  by dividing
        the  number  of  shares  of Old  Common  Stock  represented  by such Old
        Certificate(s)  immediately  prior to the time  this  amendment  becomes
        effective  by five (5) and  rounding  such  number up to the next  whole
        integer.  From and after the  Effective  Date,  Old  Certificates  shall
        represent  only the right to receive  New  Certificates  pursuant to the
        provisions  hereof.  No  certificates or scrip  representing  fractional
        share interests in New Common Stock will be issued. If more than one Old
        Certificate shall be surrendered at one time for the account of the same
        stockholder, the number of full shares of New Common Stock for which New
        Certificates  shall be  issued  shall be  computed  on the  basis of the
        aggregate  number  of  shares  represented  by the Old  Certificates  so
        surrendered. In the event that


                                      - 5 -


<PAGE>

        the  Company's   Transfer  Agent   determines   that  a  holder  of  Old
        Certificates  has not tendered all his  certificates  for exchange,  the
        Transfer  Agent  shall  carry  forward  any  fractional  share until all
        certificates  of that holder have been  presented for exchange such that
        rounding up for fractional shares to any one person shall not exceed one
        share.  If any New Certificate is to be issued in a name other than that
        in which the Old Certificates  surrendered for exchange are issued,  the
        Old Certificates so surrendered shall be properly endorsed and otherwise
        in proper form for transfer,  and the person or persons  requesting such
        exchange shall affix any requisite  stock transfer tax stamps to the Old
        Certificates  surrendered,  or  provide  funds  for their  purchase,  or
        establish to the  satisfaction of the Transfer Agent that such taxes are
        not  payable.  From and after the  Effective  Date the amount of capital
        represented  by the  shares of the New  Common  Stock into which and for
        which the  shares of the Old  Common  Stock are  reclassified  under the
        terms hereof shall be the same as the amount of capital  represented  by
        the shares of Old Common Stock so reclassified, until thereafter reduced
        or increased in accordance with applicable law.

        FURTHER RESOLVED,  that at any time prior to the filing of the foregoing
amendment to the Company's  Restated  Certificate of  Incorporation  effecting a
one-for-five Reverse Stock Split, notwithstanding  authorization of the proposed
amendment by the stockholders of the Company, the board of directors may abandon
such proposed amendment without further action by the stockholders.

        G.     One-for-Seven Reverse Stock Split.

        RESOLVED,   that,   prior  to  the  Company's  next  Annual  Meeting  of
Stockholders  following the 1998 Annual Meeting,  on the condition that no other
amendment to the Company's Restated Certificate of Incorporation shall have been
filed  subsequent to July 14, 1998 effecting a reverse stock split of the Common
Stock,  Article IV of the Company's  Restated  Certificate of  Incorporation  be
amended by addition of the following provision:

        Simultaneously with the effective date of this amendment (the "Effective
        Date"),  each share of the Company's  Common Stock,  par value $.001 per
        share,  issued and outstanding  immediately  prior to the Effective Date
        (the "Old Common Stock") shall  automatically  and without any action on
        the part of the holder thereof be  reclassified  as and changed into one
        seventh (1/7) of a share of the Company's  Common Stock, par value $.001
        per  share  (the  "New  Common  Stock"),  subject  to the  treatment  of
        fractional  share  interests  as  described  below.  Each  holder  of  a
        certificate or  certificates  which  immediately  prior to the Effective
        Date  represented  outstanding  shares  of Old  Common  Stock  (the "Old
        Certificates")  shall be entitled to receive upon  surrender of such Old
        Certificates  to  the  Company's  Transfer  Agent  for  cancellation,  a
        certificate or certificates  (the "New  Certificate")  representing  the
        number of whole  shares of the New Common Stock  determined  by dividing
        the  number  of  shares  of Old  Common  Stock  represented  by such Old
        Certificate(s)  immediately  prior to the time  this  amendment  becomes
        effective  by seven (7) and  rounding  such  number up to the next whole
        integer.  From and after the  Effective  Date,  Old  Certificates  shall
        represent  only the right to receive  New  Certificates  pursuant to the
        provisions  hereof.  No  certificates or scrip  representing  fractional
        share interests in New Common Stock will be issued. If more than one Old
        Certificate shall be surrendered at one time for the account of the same
        stockholder, the number of full shares of New Common Stock for which New
        Certificates  shall be  issued  shall be  computed  on the  basis of the
        aggregate  number  of  shares  represented  by the Old  Certificates  so
        surrendered.  In the event that the Company's  Transfer Agent determines
        that a holder of Old  Certificates has not tendered all his certificates
        for  exchange,  the Transfer  Agent shall carry  forward any  fractional
        share until all  certificates  of that holder  have been  presented  for
        exchange such that rounding up for  fractional  shares to any one person
        shall not exceed one share.  If any New Certificate is to be issued in a
        name  other  than that in which  the Old  Certificates  surrendered  for
        exchange  are  issued,  the Old  Certificates  so  surrendered  shall be
        properly  endorsed and  otherwise in proper form for  transfer,  and the
        person or persons  requesting  such  exchange  shall affix any requisite
        stock  transfer  tax  stamps  to the Old  Certificates  surrendered,  or
        provide funds for their  purchase,  or establish to the  satisfaction of
        the Transfer  Agent that such taxes are not payable.  From and after the
        Effective  Date the amount of capital  represented  by the shares of the
        New  Common  Stock into which and for which the shares of the Old Common
        Stock are  reclassified  under the terms hereof shall be the same as the
        amount of capital represented by the shares


                                      - 6 -


<PAGE>

        of Old  Common  Stock  so  reclassified,  until  thereafter  reduced  or
        increased in accordance with applicable law.

        FURTHER RESOLVED,  that at any time prior to the filing of the foregoing
amendment to the Company's  Restated  Certificate of  Incorporation  effecting a
one-for-seven Reverse Stock Split, notwithstanding authorization of the proposed
amendment by the stockholders of the Company, the board of directors may abandon
such proposed amendment without further action by the stockholders.

        H.     One-for-Ten Reverse Stock Split.

        RESOLVED,   that,   prior  to  the  Company's  next  Annual  Meeting  of
Stockholders  following the 1998 Annual Meeting,  on the condition that no other
amendment to the Company's Restated Certificate of Incorporation shall have been
filed  subsequent to July 14, 1998 effecting a reverse stock split of the Common
Stock,  Article IV of the Company's  Restated  Certificate of  Incorporation  be
amended by addition of the following provision:

        Simultaneously with the effective date of this amendment (the "Effective
        Date"),  each share of the Company's  Common Stock,  par value $.001 per
        share,  issued and outstanding  immediately  prior to the Effective Date
        (the "Old Common Stock") shall  automatically  and without any action on
        the part of the holder thereof be  reclassified  as and changed into one
        tenth (1/10) of a share of the Company's  Common Stock,  par value $.001
        per  share  (the  "New  Common  Stock"),  subject  to the  treatment  of
        fractional  share  interests  as  described  below.  Each  holder  of  a
        certificate or  certificates  which  immediately  prior to the Effective
        Date  represented  outstanding  shares  of Old  Common  Stock  (the "Old
        Certificates")  shall be entitled to receive upon  surrender of such Old
        Certificates  to  the  Company's  Transfer  Agent  for  cancellation,  a
        certificate or certificates  (the "New  Certificate")  representing  the
        number of whole  shares of the New Common Stock  determined  by dividing
        the  number  of  shares  of Old  Common  Stock  represented  by such Old
        Certificate(s)  immediately  prior to the time  this  amendment  becomes
        effective  by ten (10) and  rounding  such  number up to the next  whole
        integer.  From and after the  Effective  Date,  Old  Certificates  shall
        represent  only the right to receive  New  Certificates  pursuant to the
        provisions  hereof.  No  certificates or scrip  representing  fractional
        share interests in New Common Stock will be issued. If more than one Old
        Certificate shall be surrendered at one time for the account of the same
        stockholder, the number of full shares of New Common Stock for which New
        Certificates  shall be  issued  shall be  computed  on the  basis of the
        aggregate  number  of  shares  represented  by the Old  Certificates  so
        surrendered.  In the event that the Company's  Transfer Agent determines
        that a holder of Old  Certificates has not tendered all his certificates
        for  exchange,  the Transfer  Agent shall carry  forward any  fractional
        share until all  certificates  of that holder  have been  presented  for
        exchange such that rounding up for  fractional  shares to any one person
        shall not exceed one share.  If any New Certificate is to be issued in a
        name  other  than that in which  the Old  Certificates  surrendered  for
        exchange  are  issued,  the Old  Certificates  so  surrendered  shall be
        properly  endorsed and  otherwise in proper form for  transfer,  and the
        person or persons  requesting  such  exchange  shall affix any requisite
        stock  transfer  tax  stamps  to the Old  Certificates  surrendered,  or
        provide funds for their  purchase,  or establish to the  satisfaction of
        the Transfer  Agent that such taxes are not payable.  From and after the
        Effective  Date the amount of capital  represented  by the shares of the
        New  Common  Stock into which and for which the shares of the Old Common
        Stock are  reclassified  under the terms hereof shall be the same as the
        amount of  capital  represented  by the  shares of Old  Common  Stock so
        reclassified,  until thereafter  reduced or increased in accordance with
        applicable law.

        FURTHER RESOLVED,  that at any time prior to the filing of the foregoing
amendment to the Company's  Restated  Certificate of  Incorporation  effecting a
one-for-ten Reverse Stock Split,  notwithstanding  authorization of the proposed
amendment by the stockholders of the Company, the board of directors may abandon
such proposed amendment without further action by the stockholders.

        SECOND:  Thereafter,  pursuant to resolutions of the corporation's Board
of  Directors,  the  amendments  were  submitted  to  the  stockholders  of  the
corporation  for  approval at a Meeting of  Stockholders,  and such  meeting was
called  and held upon  notice in  accordance  with  Section  222 of the  General
Corporation  Law of the State of  Delaware.  The  necessary  number of shares as
required by statute were voted in favor of the amendment.


                                      - 7 -


<PAGE>

        THIRD:  The said  amendment  was duly  adopted  in  accordance  with the
provisions  of  Section  242 of the  General  Corporation  Law of the  State  of
Delaware.

        IN WITNESS  WHEREOF,  said corporation has caused this certificate to be
signed by Kenneth G. Kasses, Ph.D., its President, and by Robert E. Klem, Ph.D.,
its Vice President, as of this ___ day of __________________.

                                             GENTA INCORPORATED



                                             By_______________________
                                                       Kenneth G. Kasses, Ph.D.
                                                       President

Attest:



- ---------------------------
Robert E. Klem, Ph.D.
Vice President


                                      - 8 -


<PAGE>

EXHIBIT B
                            CERTIFICATE OF AMENDMENT
                                       OF
                      RESTATED CERTIFICATE OF INCORPORATION
                                       OF
                               GENTA INCORPORATED

      GENTA INCORPORATED, a corporation organized and existing under and by
virtue of the General Corporation Law of the State of Delaware,
        DOES HEREBY CERTIFY:

        FIRST:   That  at  a  meeting  of  the  Board  of   Directors  of  Genta
Incorporated,  resolutions were duly adopted setting forth a proposed  amendment
of the Restated  Certificate of Incorporation of the corporation,  and declaring
that such amendment is advisable and that such amendment  should be submitted to
the stockholders of the corporation for approval.  The resolution  setting forth
the proposed amendment is as follows:

               RESOLVED,  that the first  sentence of Article XI of the Restated
Certificate  of  Incorporation,  as  amended,  of the Company be, and hereby is,
deleted.

        SECOND:  Thereafter,  pursuant to resolutions of the corporation's Board
of Directors, the amendment was submitted to the stockholders of the corporation
for approval at a Meeting of Stockholders,  and such meeting was called and held
upon notice in accordance with Section 222 of the General Corporation Law of the
State of Delaware.  The  necessary  number of shares as required by statute were
voted in favor of the amendment.

        THIRD:  The said  amendment  was duly  adopted  in  accordance  with the
provisions  of  Section  242 of the  General  Corporation  Law of the  State  of
Delaware.

        IN WITNESS  WHEREOF,  said corporation has caused this certificate to be
signed by Kenneth G. Kasses, Ph.D., its President, and by Robert E. Klem, Ph.D.,
its Vice President, as of this ___ day of __________________.

                                              GENTA INCORPORATED


                                              By_______________________
                                                        Kenneth G. Kasses, Ph.D.
                                                        President
Attest:

- ---------------------------
Robert E. Klem, Ph.D.
Vice President


                                      - 1 -


<PAGE>

EXHIBIT C

                            CERTIFICATE OF AMENDMENT
                                       OF
                      RESTATED CERTIFICATE OF INCORPORATION
                                       OF
                               GENTA INCORPORATED

        GENTA  INCORPORATED,  a corporation  organized and existing under and by
virtue of the General Corporation Law of the State of Delaware,

        DOES HEREBY CERTIFY:

        FIRST:   That  at  a  meeting  of  the  Board  of   Directors  of  Genta
Incorporated,  resolutions were duly adopted setting forth a proposed  amendment
of the Restated  Certificate of Incorporation of the corporation,  and declaring
that such amendment is advisable and that such amendment  should be submitted to
the stockholders of the corporation for approval.  The resolution  setting forth
the proposed amendment is as follows:

               RESOLVED,  that Article X of the Certificate of  Incorporation be
deleted and replaced with the following:
               The number of directors which shall constitute the whole Board of
        Directors  of the  corporation  shall be  determined  in the  by-laws as
        provided  therein.  The directors of the corporation shall be elected by
        the  stockholders  entitled to vote  thereon at each  annual  meeting of
        stockholders  and shall hold  office  until the next  annual  meeting of
        stockholders  and until  their  respective  successors  shall  have been
        elected and qualified,  subject,  however, to prior death,  resignation,
        retirement,  disqualification or removal from office. The term of office
        of each  director in office at the time this  amendment  to Article X of
        the Restated  Certificate of  Incorporation  of the corporation  becomes
        effective  shall  expire at the time of the opening of the polls for the
        election of directors at the next annual meeting of  stockholders of the
        corporation  held  after the time this  amendment  to  Article X becomes
        effective.

        SECOND:  Thereafter,  pursuant to resolutions of the corporation's Board
of Directors, the amendment was submitted to the stockholders of the corporation
for approval at a Meeting of Stockholders,  and such meeting was called and held
upon notice in accordance with Section 222 of the General Corporation Law of the
State of Delaware.  The  necessary  number of shares as required by statute were
voted in favor of the amendment.

        THIRD:  The said  amendment  was duly  adopted  in  accordance  with the
provisions  of  Section  242 of the  General  Corporation  Law of the  State  of
Delaware.

        IN WITNESS  WHEREOF,  said corporation has caused this certificate to be
signed by Kenneth G. Kasses, Ph.D., its President, and by Robert E. Klem, Ph.D.,
its Vice President, as of this ___ day of __________________.

                                            GENTA INCORPORATED


                                            By_______________________
                                                      Kenneth G. Kasses, Ph.D.
                                                      President
Attest:

- ---------------------------
Robert E. Klem, Ph.D.
Vice President


                                      - 1 -


<PAGE>

EXHIBIT D











                               GENTA INCORPORATED

                            1998 STOCK INCENTIVE PLAN





<PAGE>

                                Table of Contents
                                                                            Page
                                    ARTICLE I
                                     GENERAL

1.1     Purpose............................................................    1
1.2     Administration.....................................................    1
1.3     Persons Eligible for Awards........................................    2
1.4     Types of Awards Under Plan.........................................    2
1.5     Shares Available for Awards........................................    2
1.6     Definitions of Certain Terms.......................................    4

                                   ARTICLE II
                              AWARDS UNDER THE PLAN

2.1     Agreements Evidencing Awards.......................................    5
2.2     No Rights as a Shareholder.........................................    6
2.3     Grant of Stock Options, Stock Appreciation
          Rights and Reload Options........................................    6
2.4     Exercise of Options and Stock Appreciation Rights..................    8
2.5     Termination of Employment; Death...................................    8
2.6     Grant of Restricted Stock..........................................    9
2.7     Grant of Restricted Stock Units....................................   10
2.8     Other Stock-Based Awards...........................................   10
2.9     Grant of Dividend Equivalent Rights................................   11
2.10    Right of Recapture.................................................   11

                                   ARTICLE III
                                  MISCELLANEOUS

3.1     Amendment of the Plan; Modification of Awards......................   11
3.2     Tax Withholding....................................................   12
3.3     Restrictions.......................................................   12
3.4     Nonassignability...................................................   13
3.5     Requirement of Notification of Election
          Under Section 83(b) of the Code..................................   13
3.6     Requirement of Notification Upon Disqualifying Disposition Under
          Section 421(b) of the Code.......................................   13
3.7     Change in Control, Dissolution, Liquidation, Merger................   13
3.8     Right of Discharge Reserved........................................   15
3.9     Nature of Payments.................................................   15
3.10    Non-Uniform Determinations.........................................   16
3.11    Other Payments or Awards...........................................   16
3.12    Section Headings...................................................   16
3.13    Effective Date and Term of Plan....................................   16
3.14    Governing Law......................................................   16


                                      - i -


<PAGE>

                                    ARTICLE I
                                     GENERAL

1.1     Purpose

               The purpose of the Genta  Incorporated  1998 Stock Incentive Plan
(the "Plan") is to provide for officers,  other  employees and directors of, and
consultants  to, Genta  Incorporated  (the  "Company") and its  subsidiaries  an
incentive  (a) to enter into and remain in the  service of the  Company,  (b) to
enhance  the  long-term  performance  of  the  Company,  and  (c) to  acquire  a
proprietary interest in the success of the Company.

1.2     Administration

               1.2.1 Subject to Section 1.2.6, the Plan shall be administered by
the  Compensation  Committee (the  "Committee") of the board of directors of the
Company (the "Board"),  which shall consist of not less than two directors.  The
members of the  Committee  shall be appointed  by, and serve at the pleasure of,
the Board. To the extent required for transactions under the Plan to qualify for
the exemptions  available under Rule 16b-3 ("Rule 16b-3")  promulgated under the
Securities Exchange Act of 1934 (the "1934 Act"), all actions relating to awards
to  persons  subject  to  Section 16 of the 1934 Act shall be taken by the Board
unless  each person who serves on the  Committee  is a  "non-employee  director"
within the meaning of Rule 16b-3 or such actions are taken by a sub-committee of
the Committee (or the Board) comprised solely of  "non-employee  directors".  To
the extent required for  compensation  realized from awards under the Plan to be
deductible  by the Company  pursuant to section  162(m) of the Internal  Revenue
Code of 1986 (the  "Code"),  the  members  of the  Committee  shall be  "outside
directors" within the meaning of section 162(m).

               1.2.2 The Committee  shall have the authority (a) to exercise all
of the  powers  granted to it under the Plan;  (b) to  construe,  interpret  and
implement the Plan and any plan agreements executed pursuant to Section 2.1; (c)
to prescribe,  or amend and rescind rules and regulations  relating to the Plan,
including  rules governing its own  operations;  (d) to make all  determinations
necessary  or advisable in  administering  the Plan;  (e) to correct any defect,
supply any omission and reconcile any  inconsistency  in the Plan;  (f) to amend
the Plan to reflect changes in applicable law; (g) to determine whether, to what
extent and under what circumstances  awards may be settled or exercised in cash,
Shares of Common Stock,  other  securities,  other awards or other property,  or
canceled,  forfeited or suspended  and the method or methods by which awards may
be settled,  canceled,  forfeited or suspended; and (h) to determine whether, to
what extent and under what  circumstances  cash,  shares of Common Stock,  other
securities,  other  awards or other  property  and other  amounts  payable  with
respect to an award shall be deferred either automatically or at the election of
the holder thereof or of the Committee.

               1.2.3  Actions of the  Committee  shall be taken by the vote of a
majority of its members.  Any action may be taken by a written instrument signed
by a majority of the  Committee  members,  and action so taken shall be fully as
effective as if it had been taken by a vote at a meeting.


                                      - 1 -


<PAGE>


               1.2.4 The  determination of the Committee on all matters relating
to the Plan or any plan agreement shall be final, binding and conclusive.

               1.2.5 No member of the  Committee  shall be liable for any action
or  determination  made in good  faith  with  respect  to the Plan or any  award
thereunder.

               1.2.6 Notwithstanding  anything to the contrary contained herein:
(a) until the Board shall appoint the members of the  Committee,  the Plan shall
be administered by the Board; and (b) the Board may, in its sole discretion,  at
any time and from time to time,  grant awards or resolve to administer the Plan.
In either of the foregoing events, the Board shall have all of the authority and
responsibility granted to the Committee herein.

1.3     Persons Eligible for Awards

               Awards  under the Plan may be made to such  directors  (including
directors who are not  employees),  officers and other  employees of the Company
and its  subsidiaries  (including  prospective  employees  conditioned  on their
becoming  employees),  and to such  consultants,  advisers and other independent
contractors of the Company and its subsidiaries  (collectively,  "key persons"),
as the Committee shall select in its discretion.

1.4     Types of Awards Under Plan

               Awards  may be made  under the Plan in the form of (a)  incentive
stock options (within the meaning of section 422 of the Code); (b) non-qualified
stock options;  (c) stock appreciation  rights; (d) dividend  equivalent rights;
(e) restricted  stock;  (f) restricted  stock units;  and (g) other  stock-based
awards, all as more fully set forth in Article II. The term "award" means any of
the foregoing.  No incentive  stock option (other than an incentive stock option
that may be assumed or issued by the Company in connection with a transaction to
which section  424(a) of the Code applies) may be granted to a person who is not
an employee of the Company on the date of grant.

1.5     Shares Available for Awards

               1.5.1  Total  shares  available.  The  total  number of shares of
common stock of the Company,  par value $.001 per share ("Common Stock"),  which
may be  transferred  pursuant to awards  granted under the Plan shall not exceed
6,750,000; provided, however, that such number of shares may be increased at any
time or from time to time, at the  discretion  of the Board of Directors,  by an
aggregate  amount  up to the  product  of (x)  .15  and  (y)  the sum of (1) the
difference  between  (A) the  number  of shares  of  Common  Stock  which may be
obtained upon conversion of the Series D Convertible Preferred Stock pursuant to
the  modification  in the conversion  price effected by the Reset, as defined in
the fifth paragraph of Subsection 4 (a) of the  Certificate of Designations  for
the Series D Convertible  Preferred  Stock, as amended from time to time, or any
contractual modification to such Reset (collectively,  the "Reset"); and (B) the
number of shares of Common  Stock  obtainable  upon  conversion  of the Series D
Convertible  Preferred Stock  immediately prior to such Reset and (2) the number
of shares of Common Stock which may be obtained upon the exercise of any


                                      - 2 -


<PAGE>

Penalty Warrants (as defined in the Company's Annual Report on Form 10-K for the
year ended December 31, 1997).  Notwithstanding the foregoing,  the total number
of incentive  stock  options (as defined in Section  1.6.2) which may be granted
may not exceed  5,000,000  shares.  Such shares may be  authorized  but unissued
Common  Stock or  authorized  and  issued  Common  Stock  held in the  Company's
treasury or acquired by the Company for the purposes of the Plan.  The Committee
may direct that any stock  certificate  evidencing shares issued pursuant to the
Plan shall bear a legend setting forth such restrictions on  transferability  as
may apply to such shares  pursuant to the Plan.  If, after the effective date of
the  Plan,  any  award is  forfeited  or any award  otherwise  terminates  or is
cancelled  without  the  delivery  of shares of Common  Stock,  then the  shares
covered  by such  award  or to which  such  award  relates  shall  again  become
available  for transfer  pursuant to awards  granted or to be granted under this
Plan. Any shares of Common Stock delivered by the Company,  any shares of Common
Stock with  respect to which  awards are made by the  Company  and any shares of
Common Stock with respect to which the Company becomes obligated to make awards,
through the assumption of, or in substitution for, outstanding awards previously
granted by an acquired entity, shall not be counted against the shares available
for awards under this Plan.

               1.5.2  Individual  Limit.  The  total  number of shares of Common
Stock with respect to which stock options and stock  appreciation  rights may be
granted to any one employee of the Company or a  subsidiary  during any two-year
period shall not exceed 8,000,000 shares.

               1.5.3  Adjustments.   Subject  to  any  required  action  by  the
shareholders  of the Company,  the number of shares of Common  Stock  covered by
each outstanding award, the number of shares available for awards, the number of
shares  that may be  subject  to awards to any one  employee,  and the price per
share  of  Common  Stock  covered  by  each  such  outstanding  award  shall  be
proportionately  adjusted  for any  increase or decrease in the number of issued
shares of Common Stock resulting from a stock split,  reverse stock split, stock
dividend,  combination  or  reclassification  of the Common Stock,  or any other
increase  or decrease in the number of issued  shares of Common  Stock  effected
without  receipt  of  consideration  by the  Company;  provided,  however,  that
conversion of any  convertible  securities of the Company shall not be deemed to
have been "effected without receipt of consideration."  Such adjustment shall be
made by the  Committee,  whose  determination  in that  respect  shall be final,
binding and conclusive. Except as expressly provided herein or in the applicable
plan  agreement,  no issuance by the Company of shares of stock of any class, or
securities  convertible into shares of stock of any class,  shall affect, and no
adjustment by reason  thereof shall be made with respect to, the number or price
of  shares of Common  Stock  subject  to an  award.  After any  adjustment  made
pursuant to this Section 1.5.3, the number of shares subject to each outstanding
award shall be rounded to the nearest whole number.


                                      - 3 -

<PAGE>

               1.5.4  Except as  provided  in this  Section  1.5 and in  Section
2.3.8,  there  shall be no limit on the  number  or the  value of the  shares of
Common Stock that may be subject to awards to any individual under the Plan.

1.6     Definitions of Certain Terms

               1.6.1 The "Fair  Market  Value" of a share of Common Stock on any
day shall be determined as follows.

                     (a) If the  principal  market  for the  Common  Stock  (the
"Market")  is a national  securities  exchange or the  National  Association  of
Securities  Dealers  Automated  Quotation System  ("NASDAQ")  National Market or
Small Cap Market, the last sale price or, if no reported sales take place on the
applicable date, the average of the high bid and low asked price of Common Stock
as  reported  for such Market on such date or, if no such  quotation  is made on
such date, on the next  preceding day on which there were  quotations,  provided
that such  quotations  shall have been made  within the ten (10)  business  days
preceding the applicable date;

                     (b) If the Common  Stock is actively  traded but  paragraph
(a) does not apply,  the  average of the high bid and low asked price for Common
Stock on the applicable  date, or, if no such quotations shall have been made on
such date, on the next  preceding day on which there were  quotations,  provided
that such  quotations  shall have been made  within the ten (10)  business  days
preceding the applicable date; or,

                     (c) In the event that neither  paragraph  (a) nor (b) shall
apply,  the Fair  Market  Value of a share of  Common  Stock on any day shall be
determined in good faith by the Committee.

               1.6.2 The term  "incentive  stock option" means an option that is
intended  to qualify  for  special  federal  income tax  treatment  pursuant  to
sections 421 and 422 of the Code, as now constituted or subsequently amended, or
pursuant to a successor provision of the Code, and which is so designated in the
applicable plan agreement.  Any option that is not specifically designated as an
incentive stock option shall under no  circumstances  be considered an incentive
stock  option.  Any option that is not an incentive  stock option is referred to
herein as a "nonqualified stock option."

               1.6.3 The term "employment" means, in the case of a grantee of an
award  under  the Plan who is not an  employee  of the  Company,  the  grantee's
association with the Company or a subsidiary as a director, consultant, adviser,
other independent contractor or otherwise.

               1.6.4  A  grantee  shall  be  deemed  to have a  "termination  of
employment"  upon  ceasing  to be  employed  by  the  Company  and  all  of  its
subsidiaries  or by a  corporation  assuming  awards in a  transaction  to which
section  424(a)  of the  Code  applies.  The  Committee  may  in its  discretion
determine  (a)  whether  any  leave of  absence  constitutes  a  termination  of
employment for purposes of the Plan;  (b) the impact,  if any, of any such leave
of absence


                                      - 4 -


<PAGE>

on  awards  theretofore  made  under  the  Plan;  and  (c)  when a  change  in a
non-employee's  association  with  the  Company  constitutes  a  termination  of
employment  for  purposes  of the Plan.  The  Committee  shall have the right to
determine whether a grantee's termination of employment is a dismissal for cause
and  the  date of  termination  in such  case,  which  date  the  Committee  may
retroactively  deem to be the date of the  action  that is cause for  dismissal.
Such determinations of the Committee shall be final, binding and conclusive.

               1.6.5 The term "cause," when used in connection with  termination
of  a   grantee's   employment,   shall  have  the  meaning  set  forth  in  any
then-effective  employment  agreement  between  the grantee and the Company or a
subsidiary  thereof. In the absence of such an employment  agreement  provision,
"cause" means: (a) conviction of any crime (whether or not involving the Company
or its  subsidiaries)  constituting a felony in the jurisdiction  involved;  (b)
engaging in any act which, in each case,  subjects,  or if generally known would
subject,  the Company or its  subsidiaries to public ridicule or  embarrassment;
(c) material violation of the Company's or a subsidiary's  policies,  including,
without  limitation,  those  relating to sexual  harassment or the disclosure or
misuse of  confidential  information;  (d) serious  neglect or misconduct in the
performance  of the grantee's  duties for the Company or a subsidiary or willful
or  repeated  failure  or  refusal  to  perform  such  duties;  in each  case as
determined by the Committee,  which  determination  shall be final,  binding and
conclusive.


                                   ARTICLE II
                              AWARDS UNDER THE PLAN

2.1     Agreements Evidencing Awards

               Each  award   granted   under  the  Plan   (except  an  award  of
unrestricted stock) shall be evidenced by a written agreement ("plan agreement")
which shall contain such  provisions as the  Committee in its  discretion  deems
necessary or desirable.  Such  provisions  may include,  without  limitation,  a
requirement  that the grantee become a party to a  shareholders'  agreement with
respect  to any  shares  of Common  Stock  acquired  pursuant  to the  award,  a
requirement  that the  grantee  acknowledge  that such shares are  acquired  for
investment  purposes  only,  and a right of  first  refusal  exercisable  by the
Company in the event that the grantee  wishes to transfer any such  shares.  The
Committee may grant awards in tandem with or in substitution for any other award
or awards  granted  under this Plan or any award granted under any other plan of
the Company or any  subsidiary.  Payments or transfers to be made by the Company
or any subsidiary upon the grant, exercise or payment of an award may be made in
such form as the Committee shall  determine,  including  cash,  shares of Common
Stock,  other  securities,  other awards or other  property and may be made in a
single payment or transfer, in installments or on a deferred basis, in each case
in accordance  with rules  established by the  Committee.  By accepting an award
pursuant to the Plan, a grantee  thereby  agrees that the award shall be subject
to all of  the  terms  and  provisions  of the  Plan  and  the  applicable  plan
agreement.


                                      - 5 -


<PAGE>

2.2     No Rights as a Shareholder

               No  grantee  of an option or stock  appreciation  right (or other
person  having the right to exercise such award) shall have any of the rights of
a shareholder  of the Company with respect to shares subject to such award until
the issuance of a stock  certificate  to such person for such shares.  Except as
otherwise  provided in Section 1.5.3, no adjustment shall be made for dividends,
distributions or other rights (whether ordinary or extraordinary, and whether in
cash,  securities  or other  property) for which the record date is prior to the
date such stock certificate is issued.

2.3     Grant of Stock Options, Stock Appreciation
        Rights and Reload Options

               2.3.1  The  Committee  may  grant  incentive  stock  options  and
nonqualified  stock  options  (collectively,  "options")  to purchase  shares of
Common Stock from the Company,  to such key persons, in such amounts and subject
to  such  terms  and  conditions,  as  the  Committee  shall  determine  in  its
discretion, subject to the provisions of the Plan.

               2.3.2 The Committee may grant stock  appreciation  rights to such
key persons,  in such amounts and subject to such terms and  conditions,  as the
Committee shall  determine in its  discretion,  subject to the provisions of the
Plan.  Stock  appreciation  rights may be granted in connection  with all or any
part of, or  independently  of,  any  option  granted  under  the Plan.  A stock
appreciation right granted in connection with a nonqualified stock option may be
granted at or after the time of grant of such option. A stock appreciation right
granted in connection  with an incentive stock option may be granted only at the
time of grant of such option.

               2.3.3 The  grantee of a stock  appreciation  right shall have the
right,  subject to the terms of the Plan and the applicable plan  agreement,  to
receive  from the  Company an amount  equal to (a) the excess of the Fair Market
Value  of a  share  of  Common  Stock  on the  date  of  exercise  of the  stock
appreciation right over (b) the exercise price of such right as set forth in the
plan  agreement  (or over the option  exercise  price if the stock  appreciation
right is granted in connection with an option),  multiplied by (c) the number of
shares with respect to which the stock appreciation right is exercised.  Payment
upon  exercise  of a stock  appreciation  right shall be in cash or in shares of
Common  Stock  (valued at their Fair Market Value on the date of exercise of the
stock  appreciation  right) or both, all as the Committee shall determine in its
discretion.  Upon  the  exercise  of  a  stock  appreciation  right  granted  in
connection  with an option,  the number of shares subject to the option shall be
correspondingly  reduced by the number of shares with respect to which the stock
appreciation  right is  exercised.  Upon the exercise of an option in connection
with which a stock  appreciation  right has been  granted,  the number of shares
subject to the stock appreciation right shall be correspondingly  reduced by the
number of shares with respect to which the option is exercised.

               2.3.4 Each plan  agreement  with  respect to an option  shall set
forth the amount (the  "option  exercise  price")  payable by the grantee to the
Company upon exercise of the


                                      - 6 -


<PAGE>

option  evidenced  thereby.  The  option  exercise  price  per  share  shall  be
determined  by the  Committee in its  discretion;  provided,  however,  that the
option exercise price of an incentive stock option shall be at least 100% of the
Fair Market  Value of a share of Common  Stock on the date the option is granted
(except as permitted in connection with the assumption or issuance of options in
a transaction to which section 424(a) of the Code applies), and provided further
that in no event shall the option exercise price be less than the par value of a
share of Common Stock.

               2.3.5  Each plan  agreement  with  respect  to an option or stock
appreciation  right shall set forth the periods during which the award evidenced
thereby shall be exercisable, whether in whole or in part. Such periods shall be
determined  by the  Committee  in its  discretion;  provided,  however,  that no
incentive stock option (or a stock appreciation right granted in connection with
an incentive  stock  option) shall be  exercisable  more than 10 years after the
date of grant.

               2.3.6 The  Committee  may in its  discretion  include in any plan
agreement with respect to an option (the "original  option") a provision that an
additional option (the "additional option") shall be granted to any grantee who,
pursuant to Section 2.4.3(b), delivers shares of Common Stock in partial or full
payment of the exercise  price of the original  option.  The  additional  option
shall be for a number  of  shares  of  Common  Stock  equal to the  number  thus
delivered,  shall have an exercise  price  equal to the Fair  Market  Value of a
share of Common Stock on the date of exercise of the original option,  and shall
have an  expiration  date no later  than  the  expiration  date of the  original
option.  In the  event  that a plan  agreement  provides  for  the  grant  of an
additional option,  such Agreement shall also provide that the exercise price of
the  original  option be no less than the Fair Market Value of a share of Common
Stock on its date of grant,  and that any shares that are delivered  pursuant to
Section  2.4.3(b) in payment of such exercise  price shall have been held for at
least six months.

               2.3.7  To  the  extent  that  the  aggregate  Fair  Market  Value
(determined  as of the time the option is granted) of the stock with  respect to
which incentive stock options granted under this Plan and all other plans of the
Company and any  subsidiary  are first  exercisable  by any employee  during any
calendar  year shall exceed the maximum  limit  (currently,  $100,000),  if any,
imposed from time to time under  section 422 of the Code,  such options shall be
treated as nonqualified stock options.

               2.3.8 Notwithstanding the provisions of Sections 2.3.4 and 2.3.5,
to the extent  required under section 422 of the Code, an incentive stock option
may not be granted under the Plan to an  individual  who, at the time the option
is granted,  owns stock  possessing  more than 10% of the total combined  voting
power of all classes of stock of his  employer  corporation  or of its parent or
subsidiary  corporations  (as such  ownership may be determined  for purposes of
section  422(b)(6)  of the Code)  unless  (a) at the time such  incentive  stock
option is granted the option  exercise price is at least 110% of the Fair Market
Value of the shares  subject  thereto and (b) the incentive  stock option by its
terms is not exercisable after the expiration of five (5) years from the date it
is granted.


                                      - 7 -


<PAGE>

2.4     Exercise of Options and Stock Appreciation Rights

               Subject to the  provisions  of this  Article  II,  each option or
stock appreciation right granted under the Plan shall be exercisable as follows:

               2.4.1 Unless the applicable plan agreement otherwise provides, an
option  or  stock   appreciation   right  shall  become   exercisable   in  four
substantially equal installments, on each of the first, second, third and fourth
anniversaries  of the date of  grant,  and  each  installment,  once it  becomes
exercisable,   shall  remain  exercisable  until  expiration,   cancellation  or
termination of the award.

               2.4.2 Unless the applicable plan agreement otherwise provides, an
option or stock  appreciation right may be exercised from time to time as to all
or part of the shares as to which such award is then  exercisable  (but,  in any
event, only for whole shares).  A stock appreciation right granted in connection
with an option may be exercised  at any time when,  and to the same extent that,
the related option may be exercised. An option or stock appreciation right shall
be  exercised by the filing of a written  notice with the Company,  on such form
and in such manner as the Committee shall prescribe.

               2.4.3 Any  written  notice  of  exercise  of an  option  shall be
accompanied  by payment for the shares being  purchased.  Such payment  shall be
made:  (a) by  certified  or  official  bank  check (or the  equivalent  thereof
acceptable to the Company) for the full option exercise price; or (b) unless the
applicable plan agreement  provides  otherwise,  by delivery of shares of Common
Stock (which, if acquired pursuant to exercise of a stock option,  were acquired
at least six months prior to the option  exercise date) and having a Fair Market
Value  (determined  as of the exercise  date) equal to all or part of the option
exercise price and a certified or official bank check (or the equivalent thereof
acceptable to the Company) for any remaining portion of the full option exercise
price; or (c) at the discretion of the Committee and to the extent  permitted by
law, by such other method as the Committee may from time to time prescribe.

               2.4.4  Promptly  after  receiving  payment  of  the  full  option
exercise  price,  or  after  receiving   notice  of  the  exercise  of  a  stock
appreciation  right for which payment will be made partly or entirely in shares,
the Company shall, subject to the provisions of Section 3.3 (relating to certain
restrictions),  deliver to the grantee or to such other  person as may then have
the right to exercise the award, a certificate or certificates for the shares of
Common  Stock for which the award has been  exercised.  If the method of payment
employed upon option  exercise so requires,  and if applicable  law permits,  an
optionee may direct the Company to deliver the  certificate(s) to the optionee's
stockbroker.

2.5     Termination of Employment; Death

               2.5.1 Except to the extent otherwise provided in Section 2.5.2 or
2.5.3 or in the applicable  plan agreement,  all options and stock  appreciation
rights  not  theretofore  exercised  shall  terminate  upon  termination  of the
grantee's employment for any reason (including death).


                                      - 8 -


<PAGE>

               2.5.2 Except to the extent  otherwise  provided in the applicable
plan agreement,  if a grantee's employment  terminates for any reason other than
death or dismissal for cause, the grantee may exercise any outstanding option or
stock appreciation right on the following terms and conditions: (a) exercise may
be made only to the extent that the grantee was  entitled to exercise  the award
on the date of employment termination; and (b) exercise must occur within ninety
(90) days after employment terminates,  except that this ninety day period shall
be increased to one year if the  termination is by reason of disability,  but in
no  event  after  the  expiration  date of the  award  as set  forth in the plan
agreement.  In the case of an incentive stock option,  the term "disability" for
purposes of the preceding sentence shall have the meaning given to it by section
422(c)(6) of the Code.

               2.5.3 Except to the extent  otherwise  provided in the applicable
plan  agreement,  if a  grantee  dies  while  employed  by  the  Company  or any
subsidiary,  or after employment  termination but during the period in which the
grantee's  awards are  exercisable  pursuant to Section 2.5.2,  any  outstanding
option or stock  appreciation  right shall be exercisable on the following terms
and conditions: (a) exercise may be made only to the extent that the grantee was
entitled to exercise the award on the date of death; and (b) exercise must occur
by the earlier of the first anniversary of the grantee's death or the expiration
date of the award.  Any such  exercise of an award  following a grantee's  death
shall be made  only by the  grantee's  executor  or  administrator,  unless  the
grantee's will specifically  disposes of such award, in which case such exercise
shall be made only by the recipient of such specific disposition. If a grantee's
personal  representative  or the recipient of a specific  disposition  under the
grantee's will shall be entitled to exercise any award pursuant to the preceding
sentence,  such  representative or recipient shall be bound by all the terms and
conditions  of the Plan and the  applicable  plan  agreement  which  would  have
applied to the grantee.

2.6     Grant of Restricted Stock

               2.6.1 The Committee may grant  restricted  shares of Common Stock
to such key persons,  in such amounts,  and subject to such terms and conditions
as the Committee shall determine in its discretion, subject to the provisions of
the Plan.  Restricted stock awards may be made independently of or in connection
with any other award under the Plan. A grantee of a restricted stock award shall
have no rights with respect to such award unless such grantee  accepts the award
within such period as the Committee  shall specify by executing a plan agreement
in such form as the Committee  shall  determine  and, if the Committee  shall so
require,  makes  payment to the Company by certified or official  bank check (or
the  equivalent  thereof  acceptable  to the  Company)  in  such  amount  as the
Committee may determine.

               2.6.2 Promptly after a grantee accepts a restricted  stock award,
the Company shall issue in the grantee's name a certificate or certificates  for
the  shares of Common  Stock  covered by the award.  Upon the  issuance  of such
certificate(s),  the grantee shall have the rights of a shareholder with respect
to the restricted  stock,  subject to the  non-transferability  restrictions and
Company repurchase rights described in Sections 2.6.4 and 2.6.5 and to such


                                      - 9 -


<PAGE>

other restrictions and conditions as the Committee in its discretion may include
in the applicable plan agreement.

               2.6.3  Unless  the  Committee  shall  otherwise  determine,   any
certificate  issued  evidencing  shares of restricted  stock shall remain in the
possession  of the  Company  until  such  shares  are  free of any  restrictions
specified in the applicable plan agreement.

               2.6.4  Shares  of  restricted  stock  may not be sold,  assigned,
transferred,   pledged  or  otherwise   encumbered  or  disposed  of  except  as
specifically  provided  in  this  Plan or the  applicable  plan  agreement.  The
Committee at the time of grant shall specify the date or dates (which may depend
upon or be related to the attainment of performance  goals and other conditions)
on which the non-transferability of the restricted stock shall lapse. Unless the
applicable plan agreement provides otherwise,  additional shares of Common Stock
or other property  distributed to the grantee in respect of shares of restricted
stock,  as dividends  or  otherwise,  shall be subject to the same  restrictions
applicable to such restricted stock.

               2.6.5 During the 120 days following  termination of the grantee's
employment  for any  reason,  the  Company  shall have the right to require  the
return of any shares to which restrictions on transferability apply, in exchange
for which the Company shall repay to the grantee (or the  grantee's  estate) any
amount paid by the grantee for such shares.

2.7     Grant of Restricted Stock Units

               2.7.1 The Committee may grant awards of restricted stock units to
such key persons,  in such amounts,  and subject to such terms and conditions as
the Committee shall  determine in its  discretion,  subject to the provisions of
the  Plan.  Restricted  stock  units  may  be  awarded  independently  of  or in
connection with any other award under the Plan.

               2.7.2 At the time of grant,  the Committee shall specify the date
or dates on which the  restricted  stock units  shall  become  fully  vested and
nonforfeitable,  and  may  specify  such  conditions  to  vesting  as  it  deems
appropriate.  In the event of the termination of the grantee's employment by the
Company and its  subsidiaries  for any reason,  restricted stock units that have
not become nonforfeitable shall be forfeited and cancelled.

               2.7.3 At the time of  grant,  the  Committee  shall  specify  the
maturity date applicable to each grant of restricted  stock units,  which may be
determined  at the  election  of the  grantee.  Such date may be later  than the
vesting date or dates of the award.  On the  maturity  date,  the Company  shall
transfer to the grantee one  unrestricted,  fully  transferable  share of Common
Stock for each  restricted  stock unit scheduled to be paid out on such date and
not previously  forfeited.  The Committee  shall specify the purchase  price, if
any, to be paid by the grantee to the Company for such shares of Common Stock.

2.8     Other Stock-Based Awards

               The  Committee  may  grant  other  types  of  stock-based  awards
(including  the  grant of  unrestricted  shares)  to such key  persons,  in such
amounts and subject to such terms


                                     - 10 -


<PAGE>

and conditions,  as the Committee shall in its discretion determine,  subject to
the provisions of the Plan. Such awards may entail the transfer of actual shares
of Common Stock to Plan participants, or payment in cash or otherwise of amounts
based on the value of shares of Common Stock.

2.9     Grant of Dividend Equivalent Rights

               The Committee may in its discretion include in the plan agreement
with respect to any award a dividend  equivalent  right entitling the grantee to
receive amounts equal to the ordinary  dividends that would be paid,  during the
time such award is outstanding  and  unexercised,  on the shares of Common Stock
covered by such award if such shares were then outstanding.  In the event such a
provision is included in a plan agreement, the Committee shall determine whether
such  payments  shall be made in cash,  in shares of Common  Stock or in another
form,  whether they shall be conditioned upon the exercise of the award to which
they relate, the time or times at which they shall be made, and such other terms
and conditions as the Committee shall deem appropriate.

2.10    Right of Recapture

               2.10.1 If at any time  within  one year after the date on which a
participant  exercises  an  option  or  stock  appreciation  right,  or on which
restricted stock vests, or which is the maturity date of restricted stock units,
or on which income is realized by a  participant  in  connection  with any other
stock-based  award  (each  of  which  events  is  a  "realization  event"),  the
participant  (a) is  terminated  for  cause  or  (b)  engages  in  any  activity
determined  in the  discretion of the  Committee to be in  competition  with any
activity  of the  Company,  or  otherwise  inimical,  contrary or harmful to the
interests of the Company  (including,  but not limited to, accepting  employment
with or serving as a consultant,  adviser or in any other  capacity to an entity
that is in  competition  with or acting  against the  interests of the Company),
then any gain realized by the participant  from the  realization  event shall be
paid by the  participant to the Company upon notice from the Company.  Such gain
shall be determined as of the date of the realization  event,  without regard to
any subsequent  change in the Fair Market Value of a share of Common Stock.  The
Company  shall have the right to offset such gain against any amounts  otherwise
owed to the  participant  by the  Company  (whether as wages,  vacation  pay, or
pursuant to any benefit plan or other compensatory arrangement).


                                   ARTICLE III
                                  MISCELLANEOUS

3.1     Amendment of the Plan; Modification of Awards

               3.1.1  The  Board  may from  time to time  suspend,  discontinue,
revise  or  amend  the  Plan  in any  respect  whatsoever,  except  that no such
amendment  shall  materially  impair  any  rights  or  materially  increase  any
obligations  under any award theretofore made under the Plan without the consent
of the grantee (or,  after the grantee's  death,  the person having the right to
exercise the award). For purposes of this Section 3.1, any action of the


                                     - 11 -


<PAGE>

Board or the  Committee  that alters or affects the tax  treatment  of any award
shall not be considered to materially impair any rights of any grantee.

               3.1.2 Shareholder  approval of any amendment shall be obtained to
the  extent  necessary  to comply  with  section  422 of the Code  (relating  to
incentive stock options) or other applicable law or regulation.

               3.1.3 The Committee  may amend any  outstanding  plan  agreement,
including,  without limitation,  by amendment which would accelerate the time or
times at which the award becomes  unrestricted or may be exercised,  or waive or
amend any goals, restrictions or conditions set forth in the Agreement. However,
any such amendment (other than an amendment pursuant to Section 3.7.2,  relating
to change in control) that materially impairs the rights or materially increases
the obligations of a grantee under an outstanding  award shall be made only with
the consent of the grantee (or, upon the grantee's  death, the person having the
right to exercise the award).

3.2     Tax Withholding

               3.2.1 As a condition to the receipt of any shares of Common Stock
pursuant  to any  award or the  lifting  of  restrictions  on any  award,  or in
connection  with  any  other  event  that  gives  rise  to a  federal  or  other
governmental  tax withholding  obligation on the part of the Company relating to
an award  (including,  without  limitation,  FICA  tax),  the  Company  shall be
entitled to require that the grantee  remit to the Company an amount  sufficient
in the opinion of the Company to satisfy such withholding obligation.

               3.2.2 If the event giving rise to the withholding obligation is a
transfer of shares of Common  Stock,  then,  unless  otherwise  specified in the
applicable  plan agreement,  the grantee may satisfy the withholding  obligation
imposed under Section 3.2.1 by electing to have the Company  withhold  shares of
Common  Stock  having  a Fair  Market  Value  equal to the  amount  of tax to be
withheld. For this purpose, Fair Market Value shall be determined as of the date
on which the amount of tax to be  withheld  is  determined  (and any  fractional
share amount shall be settled in cash).

3.3     Restrictions

               3.3.1  If the  Committee  shall at any  time  determine  that any
consent (as hereinafter defined) is necessary or desirable as a condition of, or
in connection  with,  the granting of any award under the Plan,  the issuance or
purchase of shares or other rights thereunder, or the taking of any other action
thereunder  (each such action a "plan action"),  then such plan action shall not
be taken,  in whole or in part,  unless and until such  consent  shall have been
effected or obtained to the full satisfaction of the Committee.

               3.3.2 The term  "consent" as used herein with respect to any plan
action  means  (a) any and all  listings,  registrations  or  qualifications  in
respect  thereof upon any  securities  exchange or under any  federal,  state or
local  law,  rule  or  regulation,  (b)  any  and  all  written  agreements  and
representations by the grantee with respect to the disposition of


                                     - 12 -


<PAGE>

shares,  or with respect to any other  matter,  which the  Committee  shall deem
necessary  or  desirable  to  comply  with  the  terms  of  any  such   listing,
registration  or  qualification  or to obtain an exemption from the  requirement
that any such listing, qualification or registration be made and (c) any and all
consents,  clearances  and  approvals  in  respect  of  a  plan  action  by  any
governmental or other regulatory bodies.

3.4     Nonassignability

               Except to the extent  otherwise  provided in the applicable  plan
agreement,  no award or right  granted  to any  person  under the Plan  shall be
assignable  or  transferable  other than by will or by the laws of  descent  and
distribution,  and all such awards and rights  shall be  exercisable  during the
life of the grantee only by the grantee or the grantee's legal representative.

3.5     Requirement of Notification of
        Election Under Section 83(b) of the Code

               If any grantee  shall,  in  connection  with the  acquisition  of
shares of Common Stock under the Plan, make the election permitted under section
83(b) of the Code (that is, an election  to include in gross  income in the year
of transfer the amounts  specified in section 83(b)),  such grantee shall notify
the  Company  of such  election  within  ten (10) days of  filing  notice of the
election  with the  Internal  Revenue  Service,  in  addition  to any filing and
notification required pursuant to regulations issued under the authority of Code
section 83(b).

3.6     Requirement of Notification Upon Disqualifying
        Disposition Under Section 421(b) of the Code

               If any  grantee  shall make any  disposition  of shares of Common
Stock issued  pursuant to the  exercise of an  incentive  stock option under the
circumstances  described  in  section  421(b) of the Code  (relating  to certain
disqualifying  dispositions),  such  grantee  shall  notify the  Company of such
disposition within 10 days thereof.


3.7     Change in Control, Dissolution, Liquidation, Merger

               3.7.1 For  purposes  of this  Section  3.7, a "change in control"
shall have occurred if:

                     (a) any  "person",  as such term is used in Sections  13(d)
and 14(d) of the 1934 Act (other than (i) the  shareholders of the Company as of
the effective date of the Plan (the "Current Shareholders", such term to include
their heirs or estates, or trusts or other entities the primary beneficiaries of
which are the Current  Shareholders  or persons  designated  by them),  (ii) the
Company or any subsidiary of the Company,  (iii) any trustee or other  fiduciary
holding  securities  under  an  employee  benefit  plan  of the  Company  or any
subsidiary of the Company, or (iv) any company owned, directly or indirectly, by
the shareholders of the Company in  substantially  the same proportions as their
ownership of stock of


                                     - 13 -


<PAGE>

the  Company),  is or becomes the  "beneficial  owner" (as defined in Rule 13d-3
under the 1934 Act),  directly  or  indirectly,  of  securities  of the  Company
representing  more than 50% of the combined  voting power of the Company's  then
outstanding securities without the prior written consent of the Committee or the
Board; or

                     (b)  during  any  period of  twenty-four  (24)  consecutive
months,  individuals  who at the effective date of the Plan constitute the Board
and any new director  whose  election by the Board or nomination for election by
the Company  shareholders  was  approved by a vote of at least a majority of the
directors then still in office who either were directors at the beginning of the
period or whose  election or nomination for election was previously so approved,
cease for any reason to constitute at least a majority thereof;

                     (c) the  shareholders  of the  Company  approve a merger or
consoli- dation of the Company with any other company (other than a wholly-owned
subsidiary of the Company), other than (i) a merger or consolidation which would
result in the voting  securities of the Company  outstanding  immediately  prior
thereto  continuing to represent  (either by remaining  outstanding  or by being
converted  into voting  securities of the  surviving  entity) 50% or more of the
combined  voting  power of voting  securities  of the Company or such  surviving
entity  outstanding  immediately  after such merger or  consolidation  or (ii) a
merger or consolidation  effected to implement a recapitalization of the Company
(or similar  transaction)  in which no "person" (as defined in Section  3.7.1(a)
above with the exceptions noted in section  3.7.1(a))  acquires more than 50% of
the combined voting power of the Company's then outstanding securities; or

                     (d)  the  shareholders  of the  Company  approve  a plan of
complete  liquidation of the Company or an agreement for the sale or disposition
by the  Company  of all or  substantially  all of the  Company's  assets (or any
transaction having a similar effect).

               3.7.2  Upon the happening of a change in control:

                     (a)  notwithstanding  any other provision of this Plan, any
option or stock  appreciation  right then outstanding  shall become fully vested
and immediately exercisable upon the subsequent termination of employment of the
grantee by the Company or its  successors  without cause within one year of such
change in control  unless  the  applicable  plan  agreement  expressly  provides
otherwise;

                     (b) to the fullest  extent  permitted by law, the Committee
may, in its sole discretion, amend any plan agreement in such manner as it deems
appropriate, including, without limitation, by amendments that advance the dates
upon which any or all outstanding awards of any type shall terminate.

               3.7.3 In the event of the proposed  dissolution or liquidation of
the Company,  all  outstanding  awards will terminate  immediately  prior to the
consummation  of  such  proposed  action,   unless  otherwise  provided  by  the
Committee.  The  Committee  may, in the exercise of its sole  discretion in such
instances, accelerate the date on which any award


                                     - 14 -


<PAGE>

becomes  exercisable  or  fully  vested  and/or  declare  that any  award  shall
terminate as of a specified date.

               3.7.4 In the event of a merger or consolidation ("merger") of the
Company with or into any other corporation or entity ("successor  corporation"),
outstanding  awards shall be assumed or an  equivalent  option or right shall be
substituted  by such  successor  corporation  or a parent or  subsidiary of such
successor corporation,  unless the Committee determines,  in the exercise of its
sole discretion, to accelerate the date on which an award becomes exercisable or
fully vested. In the absence of an assumption or substitution of awards,  awards
shall,  to the extent not exercised,  terminate as of the date of the closing of
the merger. For the purposes of this Section 3.7.4, an award shall be considered
assumed if, for every share of Common Stock subject thereto immediately prior to
the  merger,  the grantee has the right,  following  the merger,  to acquire the
consideration  received in the merger transaction by holders of shares of Common
Stock  (and if  holders  were  offered  a choice of  consideration,  the type of
consideration  chosen by the holders of a majority of the  outstanding  shares);
provided,  however,  that if such  consideration  received in the merger was not
solely common stock of the successor  corporation  or its parent,  the Committee
may, with the consent of the successor corporation and the participant,  provide
for the  consideration  to be acquired  pursuant to the award, for each share of
Common  Stock  subject  thereto,  to be  solely  common  stock of the  successor
corporation  or  its  parent  equal  in  fair  market  value  to the  per  share
consideration  received by holders of Common  Stock in the merger.  For purposes
hereof,  the term  "merger"  shall  include  any  transaction  in which  another
corporation  acquires  all of the issued  and  outstanding  Common  Stock of the
Company.

3.8     Right of Discharge Reserved

               Nothing in the Plan or in any plan  agreement  shall  confer upon
any grantee the right to continue in the employ of the Company or any subsidiary
or affect any right which the Company or any  subsidiary  may have to  terminate
such employment.

3.9     Nature of Payments

               3.9.1 Any and all  grants of awards  and  issuances  of shares of
Common Stock under the Plan shall be in consideration of services  performed for
the Company by the grantee.

               3.9.2 All such grants and  issuances  shall  constitute a special
incentive  payment  to the  grantee  and  shall  not be taken  into  account  in
computing the amount of salary or compensation of the grantee for the purpose of
determining any benefits under any pension, retirement,  profit-sharing,  bonus,
life  insurance  or other  benefit plan of the Company or of any  subsidiary  or
under any agreement with the grantee, unless such plan or agreement specifically
provides otherwise.


                                     - 15 -


<PAGE>

3.10  Non-Uniform Determinations

               The Committee's determinations under the Plan need not be uniform
and may be made by it selectively among persons who receive,  or are eligible to
receive,  awards  under the Plan  (whether  or not such  persons  are  similarly
situated). Without limiting the generality of the foregoing, the Committee shall
be  entitled,   among  other   things,   to  make   non-uniform   and  selective
determinations,  and to enter into non-uniform and selective Plan agreements, as
to (a) the  persons  to  receive  awards  under  the  Plan,  (b) the  terms  and
provisions  of awards under the Plan and (c) the  treatment of leaves of absence
pursuant to Section 1.6.4.

3.11  Other Payments or Awards

               Nothing contained in the Plan shall be deemed in any way to limit
or restrict the Company from making any award or payment to any person under any
other plan,  arrangement or understanding,  whether now existing or hereafter in
effect.

3.12  Section Headings

               The  section  headings  contained  herein are for the  purpose of
convenience  only and are not  intended  to define or limit the  contents of the
sections.

3.13  Effective Date and Term of Plan

               3.13.1  The Plan was  adopted  by the Board on May 28,  1998 (the
"effective date"), subject to approval by the Company's shareholders. All awards
under the Plan prior to such shareholder  approval are subject in their entirety
to  such  approval.  If  such  approval  is not  obtained  prior  to  the  first
anniversary  of the date of  adoption  of the  Plan,  the  Plan  and all  awards
thereunder shall terminate on that date.

               3.13.2 Unless sooner  terminated by the Board,  the provisions of
the Plan  respecting the grant of incentive stock options shall terminate on the
day before  the tenth  anniversary  of the  effective  date of the Plan,  and no
incentive  stock option  awards  shall  thereafter  be made under the Plan.  All
awards made under the Plan prior to its termination shall remain in effect until
such awards have been  satisfied or terminated in accordance  with the terms and
provisions of the Plan and the applicable plan agreements.

3.14  Governing Law

               All rights and obligations  under the Plan shall be construed and
interpreted in accordance with the laws of the State of Delaware, without giving
effect to principles of conflict of laws.


                                     - 16 -


<PAGE>

EXHIBIT E


                               GENTA INCORPORATED

                 NON-EMPLOYEE DIRECTORS' 1998 STOCK OPTION PLAN


1.      Purpose

               The  purpose of the Genta  Incorporated  Non-Employee  Directors'
1998  Stock  Option  Plan (the  "Plan")  is to  provide  an  incentive  to those
directors of Genta  Incorporated  (the  "Company")  who are not employees of the
Company to serve on the board of directors  of the Company (the  "Board") and to
maintain and enhance the Company's long-term performance.

2.      Administration

               The terms of the stock  options to be awarded  under the Plan are
set forth  herein and may not be varied  other than by  amendment of the Plan in
accordance  with  Section  10. To the extent that any  administrative  action is
required in connection  with the Plan,  such action shall be taken by the Board,
whose determination in such case shall be final, binding and conclusive.

3.      Shares Available for Awards

               The total number of shares of common  stock of the  Company,  par
value  $.001 per share  ("Common  Stock"),  which  may be  transferred  upon the
exercise of options  granted  under the Plan shall not exceed  3,000,000  shares
plus the number of shares underlying the options referred to in Section 5(c) (as
adjusted  as  provided  therein).  Such shares may be  authorized  and  unissued
shares,  treasury  shares or shares  acquired by the Company for the purposes of
the Plan.  Any shares of Common  Stock that are subject to a stock  option under
the Plan and that have not been transferred at the time such option is cancelled
or terminated shall again be available for options under the Plan.

4.      Persons Eligible for Stock Options

               Stock options shall be granted under the Plan only to persons who
are members of the Board and are not employees of the Company or any  subsidiary
thereof ("Eligible Directors").


                                      - 1 -


<PAGE>

5.      Grant of Stock Options

               (a) Every option  granted  under the Plan shall be subject to the
terms and  conditions set forth in the Plan, and shall be evidenced by an option
agreement which shall not be inconsistent with the provisions of the Plan.

               (b) As of the  close  of each  annual  meeting  of the  Company's
shareholders  ("Annual  Meeting"),  commencing  with the Annual Meeting in 1999,
each individual who qualifies as an Eligible  Director at the conclusion of such
meeting, excluding any Eligible Director who is then receiving a grant under the
Company's 1998 Stock Incentive Plan or any other  stock-based  compensation plan
or arrangement of the Company in connection with his or her initial  election or
appointment to the Board,  shall be granted an option to purchase  50,000 shares
of Common Stock, provided that the Eligible Director has served as a director of
the Company for at least six months prior to the date of such Annual Meeting.

               (c) Each Eligible  Director serving as a director on May 28, 1998
shall be granted  stock options to purchase the number of shares of Common Stock
set forth  below  under the  heading  "Number of Initial  Shares" at an exercise
price of $.94375 per share  (subject to  proportional  adjustment  for any stock
split or reverse stock split of the Common Stock). The exercise price and number
of shares  subject to such stock  options  shall be subject to adjustment if the
number  of shares  of  Fairly-Diluted  Common  Stock  (as  defined  below) as of
February  26,  1999 (the  "Adjustment  Date") is other  than  44,725,266  shares
(subject to  proportional  adjustment for any stock split or reverse stock split
of the  Common  Stock) as a result of any and all  Covered  Events  (as  defined
below)  occurring  prior to such time, in which case (x) the number of shares of
Common Stock  covered by the stock  option shall  increase by a number of shares
equal  to  the  percentage  set  forth  below  under  the  caption   "Applicable
Percentage"  of the number of shares of  Fairly-Diluted  Common  Stock as of the
Adjustment Date in excess of 44,725,266 that are  attributable to Covered Events
and (y) the per share  exercise  price shall be adjusted to equal the conversion
price of the Company's Series D Convertible  Preferred Stock  immediately  after
the  Reset  (as  defined  in the  fifth  paragraph  of  Subsection  4(a)  of the
Certificate of  Designations  for the Series D Convertible  Preferred  Stock, as
amended from time to time) as modified by any  contractual  modification to such
Reset  agreed to by at least a majority  of the  holders  of Series D  Preferred
Stock.  "Fairly-Diluted  Common Stock" shall mean, as of a specified  date,  the
number of shares of Common Stock that would be outstanding on such date assuming
(i) the conversion  into Common Stock on such date of all preferred stock of the
Company  outstanding  on May 28,  1998 or  issuable  upon  exercise  of warrants
outstanding  on May 28,  1998;  and (ii) the  exercise  of all  warrants  of the
Company  outstanding  on May 28,  1998 or  contractually  required  to be issued
pursuant  to an  agreement  in effect on May 28,  1998,  in each case  having an
exercise  price  per share of Common  Stock of less than  $2.00 on May 28,  1998
(subject to  proportional  adjustment for any stock split or reverse stock split
of the Common  Stock)  including,  but not limited to, any Penalty  Warrants (as
defined in the Company's  Annual  Report on Form 10-K, as amended,  for the year
ended December 31, 1997) that may be issued.  "Covered Events" mean any issuance
of  Penalty  Warrants  or  alteration  of the  conversion  price of the Series D
Preferred  Stock  pursuant  to the Reset  referred  to above or any  contractual
modification thereof.


                                     - 2 -


<PAGE>

                                                                    Applicable
Director                     Number of Initial Shares             Percentage (%)

Drapkin                              675,000                            1.5

Cooper                               337,500                             .75

Sandage                              337,500                             .75

Kessel                                75,000                             .167

Salomon                               75,000                             .167

Stein                                 75,000                             .167

Wakoff                                75,000                             .167

Weiss                                 75,000                             .167


6.      Terms of Stock Options

               (a) The  exercise  price  per share of Common  Stock  under  each
option  granted under Section 5(b) shall be equal to the "Fair Market Value" per
share of Common Stock on the date of option grant. For purposes of the Plan, the
"Fair  Market  Value" of a share of Common Stock on any day shall be as follows:
(i) if the  principal  market for the Common Stock (the  "Market") is a national
securities exchange or the National  Association of Securities Dealers Automated
Quotation System  ("NASDAQ")  National Market or SmallCap Market,  the last sale
price or, if no reported sales take place on the applicable date, the average of
the high bid and low asked price of Common  Stock as reported for such Market on
such date or, if no such  quotation is made on such date, on the next  preceding
day on which there were  quotations,  provided that such  quotations  shall have
been made within the ten (10) business days preceding the applicable  date; (ii)
If the Common  Stock is  actively  traded  but  clause  (i) does not apply,  the
average of the high bid and low asked price for Common  Stock on the  applicable
date, or, if no such  quotations  shall have been made on such date, on the next
preceding  day on which there were  quotations,  provided  that such  quotations
shall have been made within the ten (10) business days  preceding the applicable
date;  or (iii) In the event that neither  clause (i) or (ii) shall  apply,  the
Fair Market Value of a share of Common Stock on any day shall be  determined  in
good faith by the Board. The exercise price of each option granted under Section
5(c) shall be $0.94375 per share,  subject to  adjustment as provided in Section
5(c).

               (b) Each option  granted  under the Plan shall have a term of ten
years, and shall not be exercisable  after the tenth  anniversary of the date of
grant.

               (c)  Each  option   granted   under  Section  5(b)  shall  become
exercisable in full on the date of the Annual Meeting next following the date of
grant provided that the optionee  continues to serve as a member of the Board of
Directors  immediately  following such Annual Meeting. Each option granted under
Section 5(c) shall become exercisable in 16 substantially  equal installments on
the last day of each calendar quarter after October 1, 1997 provided


                                      - 3 -


<PAGE>

that adjustments to the number of options  contemplated by Section 5(c) shall be
pro-rated  as  to  vesting  over  the  remaining  quarterly  periods  after  the
adjustment.  An option may be exercised from time to time for all or part of the
shares as to which it is then  exercisable  (but,  in any event,  only for whole
shares).

7.      Exercise of Options

               (a) An  option  shall be  exercised  by the  filing  of a written
notice with the  Company,  on such form and in such manner as the Company  shall
prescribe,  accompanied by payment for the shares being purchased.  Such payment
shall be made:  (i) by  certified  or  official  bank  check (or the  equivalent
thereof  acceptable to the Company) for the full option exercise price;  (ii) by
delivery of shares of Common Stock (which,  if acquired pursuant to the exercise
of a stock  option,  were  acquired  at least  six  months  prior to the  option
exercise  date) and having a Fair Market  Value  (determined  as of the exercise
date)  equal to all or part of the  option  exercise  price and a  certified  or
official bank check (or the  equivalent  thereof  acceptable to the Company) for
any  remaining  portion  of the  full  option  exercise  price;  or (iii) at the
discretion of the Board and to the extent permitted by law, by such other method
as the Board may authorize,  including, without limitation, at the discretion of
the Board,  by the  withholding  of shares (valued at their Fair Market Value on
the date of exercise) underlying the Option.

               (b) Promptly after receiving  payment of the full option exercise
price,  the Company  shall  deliver to the Eligible  Director,  or to such other
person as may then have the right to exercise the option,  a certificate for the
shares of Common Stock for which the option has been exercised.

               (c) The  holder of a stock  option  (or other  person  having the
right to exercise the option) shall have none of the rights of a shareholder  of
the Company with respect to the shares  subject to the option until the issuance
of a stock  certificate  to such  person for such  shares.  Except as  otherwise
provided in Section 9, no adjustment shall be made for dividends,  distributions
or other  rights  (whether  ordinary  or  extraordinary,  and  whether  in cash,
securities  or other  property)  for which the record  date is prior to the date
such stock certificate is issued.

8.      Termination of Directorship; Change of Control

               (a) If an optionee's  membership on the Board  terminates for any
reason other than death, the optionee may exercise any outstanding option to the
extent that the optionee was entitled to exercise it on the date of termination.
Exercise  must occur  within  six  months  after  termination,  except  that the
six-month  period shall be increased to one year if the termination is by reason
of disability, but in no event after the expiration date of the option.

               (b) If an optionee dies while serving on the Board, or during the
period in which an option  is  exercisable  pursuant  to  paragraph  (a) of this
Section 8, any  outstanding  option shall be  exercisable to the extent that the
optionee was entitled to exercise it on the


                                      - 4 -


<PAGE>

date of death.  Exercise must occur by the earlier of the first  anniversary  of
death or the expiration date of the option.  Such exercise shall be made only by
the  optionee's   executor  or   administrator,   unless  the  optionee's   will
specifically  disposes of the option,  in which case exercise shall be made only
by the  recipient  of  such  specific  disposition.  If an  optionee's  personal
representative  or the recipient of a specific  disposition under the optionee's
will shall be entitled to exercise any award pursuant to the preceding sentence,
such  representative or recipient shall be bound by all the terms and conditions
of the Plan  and the  applicable  agreement  which  would  have  applied  to the
optionee including, without limitation, the provisions of Section 11 hereof.

               (c) Upon  expiration  of the  applicable  six-month  or  one-year
period  described  in paragraph  (a) or (b) of this  Section 8, any  unexercised
option shall be null and void.

               (d) Upon the  happening  of a change in control  (as  hereinafter
defined)  notwithstanding  any other  provision of this Plan, any option granted
under Section 5(c) then  outstanding  shall become fully vested and  immediately
exercisable  (i) upon the  termination of the Eligible  Director's  status as an
Eligible  Director  as a result of the  removal  of such  person  from the Board
(other than for cause) by  shareholder  action within one year of such change in
control  or (ii) in the  case of any  liquidation,  sale,  disposition  or other
transaction  described in clause (D) of the next sentence,  immediately upon the
consummation of such  liquidation,  sale,  disposition or other  transaction.  A
"change in control"  shall have occurred if: (A) any  "person",  as such term is
used in Sections  13(d) and 14(d) of the  Securities  Exchange  Act of 1934,  as
amended (the "1934 Act") (other than (i) the  shareholders  of the Company as of
the effective date of the Plan (the "Current Shareholders", such term to include
their heirs or estates, or trusts or other entities the primary beneficiaries of
which are the  Current  Shareholders  or persons  designated  by them,  (ii) the
Company or any subsidiary of the Company,  (iii) any trustee or other  fiduciary
holding  securities  under  an  employee  benefit  plan  of the  Company  or any
subsidiary of the Company, or (iv) any company owned, directly or indirectly, by
the shareholders of the Company in  substantially  the same proportions as their
ownership of stock of the  Company),  is or becomes the  "beneficial  owner" (as
defined in Rule 13d-3 under the 1934 Act), directly or indirectly, of securities
of the Company  representing  more than 50% of the combined  voting power of the
Company's then outstanding  securities  without the prior written consent of the
Board;  or (B)  during  any  period  of  twenty-four  (24)  consecutive  months,
individuals  who at the effective date of the Plan  constitute the Board and any
new  director  whose  election by the Board or  nomination  for  election by the
Company  shareholders  was  approved  by a vote of at  least a  majority  of the
directors then still in office who either were directors at the beginning of the
period or whose  election or nomination for election was previously so approved,
cease for any  reason to  constitute  at least a  majority  thereof;  or (C) the
shareholders  of the Company  approve a merger or  consolidation  of the Company
with any other company  (other than a  wholly-owned  subsidiary of the Company),
other  than (i) a merger or  consolidation  which  would  result  in the  voting
securities of the Company  outstanding  immediately prior thereto  continuing to
represent  (either by remaining  outstanding  or by being  converted into voting
securities of the surviving  entity) 50% or more of the combined voting power of
voting   securities  of  the  Company  or  such  surviving  entity   outstanding
immediately after such merger or consolidation


                                      - 5 -


<PAGE>

or (ii) a merger or consolidation  effected to implement a  recapitalization  of
the Company (or similar  transaction) in which no "person" (as defined in clause
(A) above with the  exceptions  noted in said clause (A)) acquires more than 50%
of the combined voting power of the Company's then  outstanding  securities;  or
(D) the  shareholders of the Company  approve a plan of complete  liquidation of
the Company or an agreement for the sale or disposition by the Company of all or
substantially  all of the Company's assets (or any transaction  having a similar
effect).

               (e) In the event of a merger or  consolidation  ("merger") of the
Company with or into any other corporation or entity ("successor  corporation"),
outstanding  awards  granted  under this Plan shall be assumed or an  equivalent
option or right shall be substituted  by such successor  corporation or a parent
or subsidiary of such successor corporation.  For the purposes of this paragraph
(e), an award shall be  considered  assumed if, for every share of Common  Stock
subject  thereto  immediately  prior to the  merger,  the grantee has the right,
following  the  merger,  to acquire  the  consideration  received  in the merger
transaction  by holders of shares of Common Stock (and if holders were offered a
choice of  consideration,  the type of consideration  chosen by the holders of a
majority  of  the  outstanding  shares);   provided,   however,   that  if  such
consideration  received  in the  merger  was  not  solely  common  stock  of the
successor  corporation  or its  parent,  the Board may,  with the consent of the
successor  corporation and the participant,  provide for the consideration to be
acquired  pursuant to the award, for each share of Common Stock subject thereto,
to be solely  common stock of the successor  corporation  or its parent equal in
fair market value to the per share  consideration  received by holders of Common
Stock in the merger.  For purposes  hereof,  the term "merger" shall include any
transaction  in  which  another  corporation  acquires  all  of the  issued  and
outstanding Common Stock of the Company.

9.      Change in Capitalization

               In the  event of any  change in the  Common  Stock by reason of a
stock  split,   reverse   stock   split,   stock   dividend,   recapitalization,
reclassification,  merger,  consolidation,  split-up,  combination,  exchange of
shares or the like, the Board shall appropriately  adjust the number and kind of
shares  authorized  for issuance under the Plan, the number of shares subject to
each option then  outstanding  or  subsequently  granted  under the Plan and the
exercise  price of each such option.  The Board's  determination  as to what, if
any,  adjustments  shall be made shall be final,  binding and  conclusive on the
Company and on all Eligible Directors who receive option grants under the Plan.

10.     Amendment of the Plan

               (a) The Board may from time to time suspend, discontinue,  revise
or amend the Plan in any respect  whatsoever;  provided,  however,  that no such
amendment shall impair any material rights or increase any material  obligations
under any option  theretofore  granted under the Plan without the consent of the
optionee  (or,  after the  optionee's  death,  the  person  having  the right to
exercise the  option).  For purposes of this Section 10, any action of the Board
that alters or affects the tax  treatment of any option shall not be  considered
to materially impair any rights of any optionee.


                                      - 6 -


<PAGE>

               (b)  Shareholder  approval  shall be required with respect to any
amendment  if the failure to obtain such  approval  would  adversely  affect the
compliance  of the Plan with the  requirements  of any  applicable  law, rule or
regulation.

11.     Restrictions

               (a) If the Board shall at any time determine that any Consent (as
hereinafter  defined)  is  necessary  or  desirable  as a  condition  of,  or in
connection  with,  the  granting of any option  under the Plan,  the issuance or
purchase of shares or other rights thereunder, or the taking of any other action
thereunder (each such action being hereinafter  referred to as a "Plan Action"),
then such Plan Action shall not be taken, in whole or in part,  unless and until
such Consent  shall have been effected or obtained to the full  satisfaction  of
the Board.

               (b) The term  "Consent"  as used herein with  respect to any Plan
Action  means  (i) any and all  listings,  registrations  or  qualifications  in
respect  thereof upon any  securities  exchange or under any  federal,  state or
local  law,  rule  or  regulation,  (ii)  any  and all  written  agreements  and
representations  by the optionee with respect to the  disposition of shares,  or
with  respect  to any other  matter,  which the Board  shall deem  necessary  or
desirable  to  comply  with  the  terms  of any such  listing,  registration  or
qualification  or to  obtain an  exemption  from the  requirement  that any such
listing,  qualification  or registration be made and (iii) any and all consents,
clearances  and  approvals  in respect of a Plan Action by any  governmental  or
other regulatory bodies.

12.     Nonassignability

               No award or right  granted to any person  under the Plan shall be
assignable  or  transferable  other than by will or by the laws of  descent  and
distribution,  and all such awards and rights  shall be  exercisable  during the
life of the grantee only by the grantee or the grantee's legal representative.

13.     No Right to Re-election

               Nothing in the Plan shall be deemed to create any  obligation  on
the part of the Board to  nominate  any of its members  for  re-election  by the
Company's  shareholders,  nor confer  upon any  Eligible  Director  the right to
remain a member of the Board for any period of time or at any particular rate of
compensation.

14.     No Limitation on Corporate Actions

               This Plan  shall not  affect in any way the right or power of the
Company  or its  shareholders  to  make  or  authorize  any or all  adjustments,
recapitalizations,  reorganizations  or other changes in the  Company's  capital
structure or its business, or any merger or consolidation of the Company, or any
issue of stock or of options,  warrants or rights to purchase stock or of bonds,
debentures, preferred or prior preference stocks whose rights are superior to or
affect the Common Stock or the rights thereof or which are  convertible  into or
exchangeable for Common Stock, or the dissolution or liquidation of the Company,
or any


                                      - 7 -


<PAGE>

sale or  transfer  of all or any part of its  assets or  business,  or any other
corporate act or proceeding, whether of a similar character or otherwise.

15.     Section Headings

               The  section  headings  contained  herein are for the  purpose of
convenience  only and are not  intended  to define or limit the  contents of the
sections.

16.     Effective Date and Term of Plan

               The Plan was  adopted  by the Board on May 28,  1998,  subject to
approval by the Company's  shareholders.  Unless sooner terminated by the Board,
the Plan  shall  terminate  on the date when no more  shares are  available  for
transfer  under the  Plan.  Options  outstanding  upon  Plan  termination  shall
continue in effect in accordance with their terms.

17.     Governing Law

               All rights and obligations  under the Plan shall be construed and
interpreted in accordance with the laws of the State of Delaware, without giving
effect to principles of conflict of laws.


                                      - 8 -


<PAGE>

                               GENTA INCORPORATED

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                      FOR ANNUAL MEETING ON JULY 14, 1998.

               The undersigned stockholder of Genta Incorporated (the "Company")
acknowledges  receipt of the Notice of Annual  Meeting of  Stockholders  and the
Proxy Statement each dated June 22, 1998 and the  undersigned  revokes all prior
proxies and appoints Kenneth G. Kasses,  Ph.D.,  Robert E. Klem, Ph.D. or either
of them,  as proxies for the  undersigned,  with full power of  substitution  to
each, to vote all shares of Common Stock and/or Series D Preferred  Stock of the
Company  which the  undersigned  is  entitled  to vote at the  Company's  Annual
Meeting of Stockholders to be held at the Harborside Hyatt  Conference  Center &
Hotel, 101 Harborside Drive, Boston,  Massachusetts,  at 11:00 a.m., local time,
on July  14,  1998  and at any  postponement  or  adjournment  thereof,  and the
undersigned  authorizes and instructs said proxies or their  substitutes to vote
as follows:


<PAGE>



1. APPROVAL OF REVERSE STOCK SPLITS OF THE COMPANY'S  OUTSTANDING  COMMON STOCK:
To approve the Company's proposed Reverse Stock Splits:
          FOR |_|                       AGAINST |_|                  ABSTAIN |_|

2. AMENDMENT  TO THE  CERTIFICATE  OF  INCORPORATION  TO REMOVE THE  STOCKHOLDER
MEETING  REQUIREMENT:  To remove the  requirement  from the  Company's  Restated
Certificate of Incorporation,  as amended, that stockholder action be taken at a
meeting:
          FOR |_|                       AGAINST |_|                  ABSTAIN |_|

3. AMENDMENT TO THE CERTIFICATE OF INCORPORATION TO ELIMINATE THE CLASSIFICATION
OF THE  BOARD  OF  DIRECTORS:  To  remove  the  classification  of the  Board of
Directors from the Company's Restated Certificate of Incorporation, as amended.
          FOR |_|                       AGAINST |_|                  ABSTAIN |_|

4. ELECTION OF CLASS I DIRECTORS:  To elect the nominees listed below to Class I
of the Board of Directors for a term of three years:
      FOR ALL NOMINEES LISTED BELOW                     WITHHOLD AUTHORITY
      (except as marked to the contrary below) |_|      to vote for all nominees
                                                        listed below         |_|

    (INSTRUCTION:  TO WITHHOLD  AUTHORITY  TO VOTE FOR ANY  INDIVIDUAL  NOMINEE,
STRIKE A LINE THROUGH THE NOMINEE'S NAME IN THE LIST BELOW.)

KENNETH G. KASSES, Ph.D.  |_|        PETER SALOMON, M.D.  |_|
ANDREW J. STEIN           |_|        HARLAN J. WAKOFF     |_|

5.  ADOPTION OF THE 1998 STOCK  INCENTIVE  PLAN AND GRANTS OF OPTIONS  UNDER THE
PLAN: To adopt the Company's 1998 Stock  Incentive Plan and to approve grants of
options under such plan:
          FOR |_|                       AGAINST |_|                  ABSTAIN |_|

6. ADOPTION OF THE NON-EMPLOYEE  DIRECTORS' 1998 STOCK OPTION PLAN AND GRANTS OF
OPTIONS UNDER THE PLAN: To adopt the  Non-Employee  Directors' 1998 Stock Option
Plan and to approve grants of options under such plan.
          FOR |_|                       AGAINST |_|                  ABSTAIN |_|

and in their  discretion,  upon any other  matters that may properly come before
the meeting or any adjournments thereof.

            (Continued and to be dated and signed on the other side.)


<PAGE>


        THIS PROXY WHEN PROPERLY  EXECUTED WILL BE VOTED IN THE MANNER  DIRECTED
HEREIN BY THE UNDERSIGNED STOCKHOLDER.  IN THE ABSENCE OF DIRECTION,  THIS PROXY
WILL BE VOTED FOR APPROVAL OF REVERSE STOCK SPLITS OF THE COMPANY'S  OUTSTANDING
COMMON STOCK,  FOR AMENDMENT TO THE CERTIFICATE OF  INCORPORATION  TO REMOVE THE
STOCKHOLDER   MEETING   REQUIREMENT,   FOR  AMENDMENT  TO  THE   CERTIFICATE  OF
INCORPORATION TO ELIMINATE THE CLASSIFICATION OF THE BOARD OF DIRECTORS, FOR THE
ELECTION OF ALL  NOMINEES  FOR CLASS I DIRECTOR,  FOR ADOPTION OF THE 1998 STOCK
INCENTIVE  PLAN AND  GRANTS  OF  OPTIONS  UNDER THE PLAN,  FOR  ADOPTION  OF THE
NON-EMPLOYEE  DIRECTORS'  1998 STOCK OPTION PLAN AND GRANTS OF OPTIONS UNDER THE
PLAN AND, IN  ACCORDANCE  WITH THE JUDGMENT OF THE  PROXIES,  FOR OR AGAINST ANY
OTHER  MATTERS  THAT  MAY  PROPERLY  COME  BEFORE  THE  ANNUAL  MEETING  AND ANY
ADJOURNMENT THEREOF.

      Receipt of the Notice of Annual  Meeting  and of the Proxy  Statement  and
Annual Report of the Company accompanying the same is hereby acknowledged.


      PLEASE  DATE,  SIGN AND RETURN  THIS  PROXY  PROMPTLY  USING THE  ENCLOSED
ENVELOPE.


                                           Dated: _______________________, 1998


                                           ------------------------------------
                                           (Signature of Stockholder)



                                           ------------------------------------
                                           (Signature of Stockholder)

                                           Please  sign  exactly as your
                                           name(s) appears on your stock
                                           certificate.  If  signing  as
                                           attorney,           executor,
                                           administrator,   trustee   or
                                           guardian, please indicate the
                                           capacity  in  which  signing.
                                           When    signing    as   joint
                                           tenants,  all  parties to the
                                           joint tenancy must sign. When
                                           the   proxy  is  given  by  a
                                           corporation,   it  should  be
                                           signed   by   an   authorized
                                           officer.



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