GENTA INCORPORATED /DE/
SC 13D/A, 1999-09-22
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                              AMENDED SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 16)*

                               Genta Incorporated
                                (Name of Issuer)

                     Common Stock, par value $.001 per share
                         (Title of Class of Securities)

                                  372 45 M 20 7
                                 (CUSIP Number)

                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                                 with a copy to:
David M. Tanen                                            Monica C. Lord, Esq.
Paramount Capital Asset                                   Kramer Levin
Management, Inc.                                          Naftalis & Frankel LLP
787 Seventh Avenue                                        919 Third Avenue
New York, NY 10019                                        New York, NY  10022
(212) 554-4356                                            (212) 715-9100

(Name,  Address and Telephone Number of Person Authorized to Receive Notices and
Communications)

                                 August 30, 1999
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following:
|-|

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule 13d- 1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                               Page 1 of 14 Pages

<PAGE>

- --------------------------------------                --------------------------
      CUSIP No. 372 45 M 20 7               13D            Page 2 of 14 Pages
- --------------------------------------                --------------------------

- --------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP      (a)    |_|
                                                                    (b)    |_|
- --------------------------------------------------------------------------------
     3        SEC USE ONLY

- --------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- --------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e) |-|
- --------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware
- --------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY              --------------------------------------------
                EACH                        8       SHARED VOTING POWER
             REPORTING
               PERSON                               24,057,609
                WITH                --------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                    --------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    24,057,609
- --------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              24,057,609
- --------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*
                                                                          |_|
- --------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              64.5% (57.0% of the outstanding voting power)**
- --------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              CO
- --------------------------------------------------------------------------------

** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer. As of September 14, 1999,  Paramount Capital
Asset Management,  Inc. may be deemed beneficially to own (within the meaning of
Rule 13d-3 under the  Securities  Exchange Act of 1934, as amended) 57.0% of the
aggregate  voting  power  of the  Common  Stock  and  Series D  Preferred  Stock
outstanding.

<PAGE>

- --------------------------------------                 -------------------------
      CUSIP No. 372 45 M 20 7                 13D          Page 3 of 14 Pages
- --------------------------------------                 -------------------------

- --------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP      (a)    |_|
                                                                    (b)    |_|

- --------------------------------------------------------------------------------
     3        SEC USE ONLY

- --------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- --------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e)
                                                                         |-|
- --------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware
- --------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY              --------------------------------------------
                EACH                        8       SHARED VOTING POWER
             REPORTING
               PERSON                               7,858,219
                WITH                --------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                    --------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    7,858,219
- --------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              7,858,219
- --------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*
                                                                    |_|
- --------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              29.7% (21.5% of the outstanding voting power)**
- --------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              PN
- --------------------------------------------------------------------------------

** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer. As of September 14, 1999, the Aries Domestic
Fund,  L.P. may be deemed  beneficially to own (within the meaning of Rule 13d-3
under the  Securities  Exchange Act of 1934, as amended)  21.5% of the aggregate
voting power of the Common Stock and Series D Preferred Stock outstanding.

<PAGE>

- --------------------------------------                 -------------------------
      CUSIP No. 372 45 M 20 7              13D             Page 4 of 14 Pages
- --------------------------------------                 -------------------------

- --------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Aries Domestic Fund II, L.P.
- --------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP       (a)   |_|
                                                                     (b)   |_|

- --------------------------------------------------------------------------------
     3        SEC USE ONLY

- --------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- --------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e)
                                                                          |-|
- --------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware
- --------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY               -------------------------------------------
                EACH                        8       SHARED VOTING POWER
             REPORTING
               PERSON                               139,258
                WITH
                                     -------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                     -------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    139,258
- --------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              139,258
- --------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*
                                                                      |_|
- --------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              0.7% (0.4% of the outstanding voting power)**
- --------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              PN
- --------------------------------------------------------------------------------

** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer. As of September 14, 1999, the Aries Domestic
Fund II,  L.P.  may be deemed  beneficially  to own  (within the meaning of Rule
13d-3  under  the  Securities  Exchange  Act of 1934,  as  amended)  0.4% of the
aggregate  voting  power  of the  Common  Stock  and  Series D  Preferred  Stock
outstanding.

<PAGE>

- --------------------------------------                 -------------------------
      CUSIP No. 372 45 M 20 7             13D              Page 5 of 14 Pages
- --------------------------------------                 -------------------------

- --------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              The Aries Master Fund
- --------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)    |_|
                                                                  (b)    |_|
- --------------------------------------------------------------------------------
     3        SEC USE ONLY

- --------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- --------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e)
                                                                          |-|
- --------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Cayman Islands

- --------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY              --------------------------------------------
                EACH                        8       SHARED VOTING POWER
             REPORTING
               PERSON                               16,060,131
                WITH
                                    --------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                    --------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    16,060,131
- --------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              16,060,131
- --------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*
                                                                         |_|
- --------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              50.78% (40.8% of the outstanding voting power)**
- --------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON* OO (see Item 2)
- --------------------------------------------------------------------------------

** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders  of the Issuer.  As of September 14, 1999, The Aries Master
Fund may be deemed  beneficially  to own (within the meaning of Rule 13d-3 under
the Securities  Exchange Act of 1934, as amended) 40.8% of the aggregate  voting
power of the Common Stock and Series D Preferred Stock outstanding.

<PAGE>

- --------------------------------------                 -------------------------
      CUSIP No. 372 45 M 20 7              13D             Page 6 of 14 Pages
- --------------------------------------                 -------------------------

- --------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP      (a)    |_|
                                                                    (b)    |_|
- --------------------------------------------------------------------------------
     3        SEC USE ONLY

- --------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- --------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
              TO ITEM 2(d) or 2(e)
                                                                        |-|
- --------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- --------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            2,866,393**
              OWNED BY              --------------------------------------------
                EACH                        8       SHARED VOTING POWER
             REPORTING
               PERSON                               26,784,481
                WITH                --------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    2,866,393**
                                    --------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    26,784,481
- --------------------------------------------------------------------------------
    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              26,784,481**
- --------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
              SHARES*
                                                                 |_|
- --------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              67.1% (59.6% of the outstanding voting power)**
- --------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              IN
- --------------------------------------------------------------------------------

** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of  stockholders  of the  Issuer.  As of  September  14,  1999,  Lindsay A.
Rosenwald,  M.D. may be deemed  beneficially  to own (within the meaning of Rule
13d-3  under the  Securities  Exchange  Act of 1934,  as  amended)  59.6% of the
aggregate  voting  power  of the  Common  Stock  and  Series D  Preferred  Stock
outstanding.

<PAGE>

                                  SCHEDULE 13D

               This Amendment No. 16 amends and supplements the following items
of the Reporting Persons' Amended and Restated Schedule 13D, dated November 1,
1998, as amended to date (the "Schedule").

Item 2.        Identity and Background

               Item 2 is hereby  amended and restated to read in its entirety as
follows:

        (a)    This  statement  is filed on behalf of  Paramount  Capital  Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
               ("Aries  Domestic"),  The Aries Master  Fund(1),  a Cayman Island
               exempted  company  ("Aries  Fund"),   Dr.  Lindsay  A.  Rosenwald
               (together with Paramount Capital,  Aries Domestic and Aries Fund,
               the "Aries  Reporting  Persons") and Aries Domestic Fund II, L.P.
               ("Aries  Domestic  II" and,  together  with the  Aries  Reporting
               Persons, the "Filing Persons").  See attached Exhibit AF which is
               a copy of their  agreement  in  writing  to file  this  statement
               jointly on behalf of each of them.  The Filing Persons have made,
               and will continue to make, their own investment decisions.

        (b)    The business address of Paramount Capital, Aries Domestic,  Aries
               Domestic II and Dr. Rosenwald is 787 Seventh Avenue,  48th Floor,
               New York, New York 10019.  The business address for Aries Fund is
               c/o MeesPierson (Cayman) Limited, P.O. Box 2003, British American
               Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

        (c)    Dr. Rosenwald is an investment banker,  venture capitalist,  fund
               manager  and  sole   shareholder   of  Paramount   Capital,(2)  a
               Subchapter S corporation  incorporated  in the State of Delaware.
               Paramount Capital is the General Partner of Aries  Domestic,(3) a
               limited partnership organized under the laws of Delaware.

- --------------------

(1)     In September of 1998 Aries Trust  transferred all of its assets to Aries
        Fund. All  references to "Aries Trust" with respect to events  occurring
        after September, 1998, should be read as Aries Fund.

(2)     Please see Exhibit B, filed herewith,  indicating the executive officers
        and directors of Paramount Capital and providing  information called for
        by  Items  2-6 of this  statement  as to said  officers  and  directors.
        Exhibit B is herein incorporated by reference.

(3)     Please see Exhibit C indicating  the general  partner of Aries  Domestic
        and the general partner's executive officers and directors and providing
        information called for by Items 2-6 of this statement as to said general
        partner,  officers and directors.  Exhibit C is herein  incorporated  by
        reference.

                               Page 7 of 14 Pages

<PAGE>

        Paramount  Capital is the Investment  Manager to Aries Fund,(4) a Cayman
        Island  exempted  company.  Paramount  is the  General  Partner of Aries
        Domestic  II,(5)  a  limited  partnership  organized  under  the laws of
        Delaware.

        (d)    Dr. Rosenwald,  Paramount Capital, Aries Domestic, Aries Domestic
               II and  Aries  Fund and  their  respective  officers,  directors,
               general  partners,  investment  managers,  and trustees have not,
               during the five years prior to the date hereof, been convicted in
               a criminal  proceeding  (excluding  traffic violations or similar
               misdemeanors).

        (e)    Dr. Rosenwald,  Paramount Capital, Aries Domestic, Aries Domestic
               II and  Aries  Fund and  their  respective  officers,  directors,
               general  partners,  investment  managers,  and trustees  have not
               been, during the five years prior to the date hereof,  parties to
               a  civil  proceeding  of a  judicial  or  administrative  body of
               competent  jurisdiction,  as a result of which such person was or
               is subject to a judgment,  decree or final order enjoining future
               violations of, or prohibiting or mandating activities subject to,
               Federal or State  securities  laws or funding any violation  with
               respect to such laws.

        (f)    Dr. Rosenwald is a citizen of the United States.

Item 3.        Source and Amount of Funds or Other Consideration

               The  information  contained  in Item 3 to the  Schedule is hereby
amended by adding the following:

               Between July 30, 1999 and September 14, 1999,  Aries Fund,  Aries
Domestic and Aries Domestic II used their  respective  general funds to purchase
207,309, 118,956 and 80,855 shares of Common Stock (additional "Purchased Common
Stock"),  respectively,  on the open market.  Further,  on August 30, 1999,  the
Issuer declared a dividend on the outstanding  shares Series D Preferred  Stock,
which  was  paid in  shares  of  Common  Stock  of the  Issuer  (the  "Series  D
Dividend").  Aries Fund received 363,592 shares of Common Stock of the Issuer as
a result of its ownership of 49,020 shares of Series D Preferred Stock and Aries
Domestic  received  195,777  shares of Common Stock of the Issuer as a result of
its ownership of 26,395 shares of Series D Preferred Stock. Simultaneously, with
the Series D dividend,  the Issuer declared a dividend on its outstanding shares
of Series A  Preferred  Stock,  which was paid in shares of Common  Stock of the
Issuer (the "Series A  Dividend").  The Aries Fund  received  692,334  shares of
Common

- ---------------
(4)     Please see  Exhibit D  indicating  the  investment  manager of the Aries
        Trust and the investment  manager's executive officers and directors and
        providing  information  called for by Items 2-6 of this  statement as to
        said investment manager and officers and directors.  Exhibit D is herein
        incorporated by reference.

(5)     Please see Exhibit AG indicating  the general  partner of Aries Domestic
        II and the  general  partner's  executive  officers  and  directors  and
        providing  information  called for by Items 2-6 of this  statement as to
        said  general  partner,  officers  and  directors.  Exhibit AG is herein
        incorporated by reference.

                               Page 8 of 14 Pages

<PAGE>

Stock of the Issuer as a result of its  ownership of 180,700  shares of Series A
Preferred  Stock and Aries Domestic  received  268,581 shares of Common Stock of
the Issuer as a result of its  ownership of 70,100  shares of Series A Preferred
Stock.

                    Aries Fund made the following purchases:

Date                      No. of Shares         Purchase Price
- ----                      -------------         --------------
08/02/99                       3,440              $   2.685
08/05/99                       2,133              $   2.750
08/09/99                       3,440              $   2.630
08/09/99                       3,440              $   2.563
08/10/99                       3,440              $   2.613
08/10/99                       6,880              $   2.611
08/11/99                       6,880              $   2.547
08/11/99                       6,880              $   2.500
08/12/99                       3,440              $   2.790
08/12/99                       3,440              $   2.550
08/13/99                       3,440              $   2.664
08/13/99                       6,880              $   2.688
08/16/99                       3,440              $   2.750
08/16/99                       3,440              $   2.763
08/17/99                       3,440              $   2.810
08/18/99                       3,440              $   2.750
08/18/99                       3,440              $   2.710
08/19/99                       3,440              $   2.938
08/19/99                       6,880              $   2.570
08/19/99                       3,440              $   2.553
08/20/99                       3,440              $   2.563
08/20/99                       6,880              $   2.628
08/23/99                       3,440              $   2.750
08/23/99                       3,440              $   2.562
08/24/99                       6,880              $   2.415
08/24/99                       6,880              $   2.435
08/25/99                       3,440              $   2.344
08/26/99                       6,880              $   2.625
08/26/99                       6,880              $   2.663
08/30/99                       3,440              $   2.520
08/30/99                       6,880              $   2.433
08/31/99                      13,760              $   2.685
09/01/99                       6,880              $   2.531
09/02/99                       6,880              $   2.442
09/09/99                      11,451              $   2.375
09/10/99                      11,451              $   2.375
09/13/99                       6,857              $   2.406


                               Page 9 of 14 Pages

<PAGE>

09/14/99                       6,857              $   2.438



                  Aries Domestic made the following purchases:


Date                       No. of Shares         Purchase Price
- ----                       -------------         --------------
08/02/99                        1,480              $   2.685
08/05/99                          917              $   2.750
08/05/99                        1,480              $   2.746
08/06/99                        8,877              $   2.677
08/06/99                        5,918              $   2.720
08/09/99                        1,480              $   2.630
08/09/99                        1,480              $   2.563
08/10/99                        1,480              $   2.613
08/10/99                        2,959              $   2.611
08/11/99                        2,959              $   2.547
08/11/99                        2,959              $   2.500
08/12/99                        1,480              $   2.790
08/12/99                        1,480              $   2.550
08/13/99                        2,959              $   2.664
08/13/99                        1,480              $   2.688
08/16/99                        1,480              $   2.750
08/16/99                        1,480              $   2.763
08/17/99                        1,480              $   2.810
08/18/99                        1,480              $   2.750
08/18/99                        1,480              $   2.710
08/19/99                        1,480              $   2.938
08/19/99                        1,480              $   2.570
08/19/99                        2,959              $   2.553
08/20/99                        2,959              $   2.563
08/20/99                        1,480              $   2.628
08/23/99                        1,480              $   2.750
08/23/99                        1,480              $   2.562
08/24/99                        2,959              $   2.415
08/24/99                        2,959              $   2.435
08/25/99                        1,480              $   2.344
08/26/99                        2,959              $   2.625
08/26/99                        2,959              $   2.663
08/30/99                        1,480              $   2.520
08/30/99                        2,959              $   2.433
08/31/99                        5,918              $   2.685
09/01/99                        2,959              $   2.531
09/02/99                       16,300              $   2.442
09/09/99                        4,978              $   2.375


                               Page 10 of 14 Pages

<PAGE>

   09/10/99                     4,978              $   2.375
   09/13/99                     2,981              $   2.406
   09/14/99                     2,981              $   2.438


                 Aries Domestic II made the following purchases:


Date                      No. of Shares         Purchase Price
- ----                      -------------         --------------
08/02/99                           81              $   2.685
08/02/99                        5,000              $   2.813
08/03/99                       10,000              $   2.991
08/04/99                       15,000              $   2.708
08/04/99                        5,000              $   2.688
08/05/99                        1,950              $   2.750
08/05/99                           80              $   2.746
08/06/99                          483              $   2.677
08/06/99                          322              $   2.720
08/09/99                           80              $   2.630
08/09/99                           80              $   2.563
08/10/99                           80              $   2.613
08/10/99                          161              $   2.611
08/11/99                          161              $   2.547
08/11/99                          161              $   2.500
08/12/99                           80              $   2.790
08/12/99                           80              $   2.550
08/13/99                          161              $   2.664
08/13/99                           80              $   2.688
08/16/99                           80              $   2.750
08/16/99                           80              $   2.763
08/17/99                           80              $   2.810
08/18/99                           80              $   2.750
08/18/99                           80              $   2.710
08/19/99                          161              $   2.938
08/19/99                           80              $   2.570
08/19/99                           80              $   2.553
08/20/99                           80              $   2.563
08/20/99                          161              $   2.628
08/23/99                           80              $   2.750
08/23/99                           80              $   2.562
08/24/99                          161              $   2.415
08/24/99                          161              $   2.435
08/25/99                           80              $   2.344
08/26/99                          161              $   2.625
08/26/99                          161              $   2.663


                               Page 11 of 14 Pages

<PAGE>

08/30/99                           80              $   2.520
08/30/99                          161              $   2.433
08/31/99                          322              $   2.685
09/01/99                          161              $   2.531
09/03/99                       10,000              $   2.438
09/03/99                       16,700              $   2.381
09/07/99                       16,700              $   2.344
09/09/99                          271              $   2.375
09/10/99                          271              $   2.375
09/13/99                          162              $   2.406
09/14/99                          162              $   2.438


Item 5.        Interest in Securities of Issuer.

        The  information  contained in Item 5 to the Schedule is hereby  amended
and supplemented to read as follows:

               (a)    As  of  August  9,  1999:  Dr.  Rosenwald,   as  the  sole
                      shareholder  of  Paramount  Capital  and as the  holder of
                      Placement  Warrants and Advisory  Warrants,  may be deemed
                      beneficially  to own  26,784,481  shares  or  67.1% of the
                      Issuer's  Common  Stock;  Paramount  Capital,  through the
                      acquisitions  of securities by Aries Fund,  Aries Domestic
                      and Aries Domestic II, may be deemed  beneficially  to own
                      24,057,609  shares or 64.5% of the Issuer's  Common Stock.
                      Aries Fund,  Aries  Domestic and Aries  Domestic II may be
                      deemed beneficially to own the following numbers of shares
                      of Common Stock:

                      Aries Fund                     16,060,131
                      Aries Domestic                  7,858,219
                      Aries Domestic II                 139,258

                      Pursuant to Rule 13d-4  promulgated  under the  Securities
                      Exchange  Act of 1934,  as  amended,  the  Filing  Persons
                      disclaim  beneficial  ownership  of all the  Common  Stock
                      except the Purchased Common Stock.  Pursuant to Rule 13d-4
                      promulgated under the Securities  Exchange Act of 1934, as
                      amended,  the  Filing  Persons  each  disclaim  beneficial
                      ownership of the securities held by each other.

                      The outstanding  shares of Series D Preferred Stock of the
                      Issuer are entitled to vote  together  with the holders of
                      Common  Stock  on  all  matters  submitted  to a  vote  of
                      stockholders of the Issuer.  As of September 14, 1999, Dr.
                      Rosenwald, Paramount Capital and Aries Trust may be deemed
                      beneficially  to own  (within  the  meaning  of Rule 13d-3
                      under the  Securities  Exchange  Act of 1934,  as amended)
                      59.6 %, 57.0 % and 40.8 %,

                               Page 12 of 14 Pages

<PAGE>

                      respectively,  of the aggregate voting power of the Common
                      Stock and Series D Preferred Stock outstanding.

               (b)    Dr.  Rosenwald  and  Paramount  Capital share the power to
                      vote or to direct the vote and to dispose or to direct the
                      disposition  of those  shares owned by each of Aries Fund,
                      Aries  Domestic and Aries  Domestic II. Dr.  Rosenwald has
                      the  sole  power  to vote or to  direct  the  vote  and to
                      dispose  or  to  direct  the  disposition  of  the  shares
                      underlying  the Placement  Warrants and Advisory  Warrants
                      held by him

               (c)    Other than certain of the open market  purchases of Common
                      Stock reported in Item 3 and in Item 3 of Amendment No. 15
                      to  Schedule  13D  filed on  August 9,  1999,  the  Filing
                      Persons have not engaged in any transactions in the Common
                      Stock of the Issuer in the past 60 days.

               (d)&(e)              Not applicable.




                               Page 13 of 14 Pages

<PAGE>

                                   SIGNATURES

               After reasonable  inquiry and to the best knowledge and belief of
the undersigned,  the undersigned certify that the information set forth in this
statement is true, complete and correct.

                                 PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  September 14, 1999
        New York, NY             By: ________________________________
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman


                                     THE ARIES MASTER FUND
                                     By: Paramount Capital Asset Management,
                                         Inc.
                                         Investment Manager

Dated:  September 14, 1999
        New York, NY             By: ________________________________
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman

                                     ARIES DOMESTIC FUND, L.P.
                                     By: Paramount Capital Asset Management,
                                         Inc.
                                         General Partner

Dated:  September 14, 1999
        New York, NY             By: ________________________________
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman

                                     ARIES DOMESTIC FUND II, L.P.
                                     By: Paramount Capital Asset Management,
                                         Inc.
                                         General Partner

Dated:  September 14, 1999
        New York, NY             By: ________________________________
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman


Dated:  September 14, 1999
        New York, NY             ____________________________________
                                     Lindsay A. Rosenwald, M.D.


                               Page 14 of 14 Pages




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