GENTA INCORPORATED /DE/
SC 13D/A, 1999-02-10
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                              AMENDED SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 12)*

                               Genta Incorporated
                               ------------------
                                (Name of Issuer)

                     Common Stock, par value $.001 per share
                     ---------------------------------------
                         (Title of Class of Securities)

                                  372 45 M 20 7
                                  -------------
                                 (CUSIP Number)

                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                                 with a copy to:
Michael S. Weiss                                   Monica C. Lord, Esq.
Paramount Capital Asset                            Kramer Levin
   Management, Inc.                                  Naftalis & Frankel LLP
787 Seventh Avenue                                 919 Third Avenue
New York, NY 10019                                 New York, NY  10022
(212) 554-4372                                     (212) 715-9100

(Name, Address and Telephone Number of Person Authorized to Receive Notices and
Communications)

                                February 1, 1999
                                -----------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following:
   |_|

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule 13d- 1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                               Page 1 of 11 Pages




<PAGE>


<TABLE>
<CAPTION>

- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                            Page 2 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
<S>                                                                             <C>

     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Paramount Capital Asset Management, Inc.
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     |_|

- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware

- -------------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ------------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    19,236,216
                                     ------------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                     ------------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    19,236,216
- -------------------------------------------------------------------------------------------------------------------

    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              19,236,216
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              66.7% (50.2% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              CO
- -----------------------------------------------------------------------------------------------------------------
** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer.  As of February 8, 1999,  Paramount  Capital
Asset Management,  Inc. may be deemed beneficially to own (within the meaning of
Rule 13d-3 under the  Securities  Exchange Act of 1934, as amended) 50.2% of the
aggregate  voting  power  of the  Common  Stock  and  Series D  Preferred  Stock
outstanding.



<PAGE>


- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 3 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Aries Domestic Fund, L.P.
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     |_|

- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Delaware

- -------------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ------------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    6,564,464
                                     ------------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                     ------------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    6,564,464
- -------------------------------------------------------------------------------------------------------------------

    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              6,564,464
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              36.1% (19.9% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              PN
- -----------------------------------------------------------------------------------------------------------------
** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders  of the Issuer.  As of February 8, 1999, the Aries Domestic
Fund,  L.P. may be deemed  beneficially to own (within the meaning of Rule 13d-3
under the  Securities  Exchange Act of 1934, as amended)  19.9% of the aggregate
voting power of the Common Stock and Series D Preferred Stock outstanding.



<PAGE>


- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 4 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              The Aries Trust
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     |_|
- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              Cayman Islands

- -------------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ------------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    12,671,751
                                     ------------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                     ------------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    12,671,751
- -------------------------------------------------------------------------------------------------------------------

    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              12,671,751
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              54.4% (35.6% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON* OO (see Item 2)
- -----------------------------------------------------------------------------------------------------------------
** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer.  As of February 8, 1999, The Aries Trust may
be deemed  beneficially  to own  (within  the  meaning of Rule  13d-3  under the
Securities Exchange Act of 1934, as amended) 35.6% of the aggregate voting power
of the Common Stock and Series D Preferred Stock outstanding.


<PAGE>

- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 5 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Lindsay A. Rosenwald, M.D.
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     |_|
- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States

- -------------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            2,866,393**
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ------------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    19,236,216
                                     ------------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    2,866,393**
                                     ------------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    19,236,216
- -------------------------------------------------------------------------------------------------------------------

    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              22,102,609**
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              69.7% (53.6% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              IN
- -----------------------------------------------------------------------------------------------------------------
** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote  of  stockholders  of the  Issuer.  As of  February  8,  1999,  Lindsay  A.
Rosenwald,  M.D. may be deemed  beneficially  to own (within the meaning of Rule
13d-3  under the  Securities  Exchange  Act of 1934,  as  amended)  53.6% of the
aggregate  voting  power  of the  Common  Stock  and  Series D  Preferred  Stock
outstanding.


<PAGE>


- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 6 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Hawkins Group, LLC
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     [x]
- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              OO (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States

- -------------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            None
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ------------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    526,737
                                     ------------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    None
                                     ------------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    526,737
- -------------------------------------------------------------------------------------------------------------------

    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              526,737
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              4.0% (1.7% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON* OO (See Item 2)
- -----------------------------------------------------------------------------------------------------------------

** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer.  As of February 8, 1999,  Hawkins Group, LLC
may be deemed  beneficially  to own  (within the meaning of Rule 13d-3 under the
Securities  Exchange Act of 1934, as amended) 1.7% of the aggregate voting power
of the Common Stock and Series D Preferred Stock outstanding.


<PAGE>


- --------------------------------------                                   ----------------------------------------
      CUSIP No. 372 45 M 20 7                          13D                          Page 7 of 11 Pages
- --------------------------------------                                   ----------------------------------------

- -----------------------------------------------------------------------------------------------------------------
     1        NAMES OF REPORTING PERSONS
              S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              Mr. Michael S. Weiss
- -----------------------------------------------------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                        (a)     |_|
                                                                                      (b)     [x]
- -----------------------------------------------------------------------------------------------------------------
     3        SEC USE ONLY

- -----------------------------------------------------------------------------------------------------------------
     4        SOURCE OF FUNDS*

              PF (see Item 3)
- -----------------------------------------------------------------------------------------------------------------
     5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
              ITEM 2(d) or 2(e)
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
     6        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States

- -------------------------------------------------------------------------------------------------------------------
             NUMBER OF                      7       SOLE VOTING POWER
               SHARES
            BENEFICIALLY                            148,327
              OWNED BY
                EACH
             REPORTING
               PERSON
                WITH
                                     ------------------------------------------------------------------------------
                                            8       SHARED VOTING POWER

                                                    526,737
                                     ------------------------------------------------------------------------------
                                            9       SOLE DISPOSITIVE POWER

                                                    148,327
                                     ------------------------------------------------------------------------------
                                           10       SHARED DISPOSITIVE POWER

                                                    526,737
- -------------------------------------------------------------------------------------------------------------------

    11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              675,064
- -----------------------------------------------------------------------------------------------------------------
    12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*
                                                                                              |_|
- -----------------------------------------------------------------------------------------------------------------
    13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

              5.1%(2.2% of the outstanding voting power)**
- -----------------------------------------------------------------------------------------------------------------
    14        TYPE OF REPORTING PERSON*
              IN
- -----------------------------------------------------------------------------------------------------------------

</TABLE>


** The outstanding shares of Series D Preferred Stock of the Issuer are entitled
to vote together with the holders of Common Stock on all matters  submitted to a
vote of stockholders of the Issuer. As of February 8, 1999, Mr. Michael S. Weiss
may be deemed  beneficially  to own  (within the meaning of Rule 13d-3 under the
Securities  Exchange Act of 1934, as amended) 2.2% of the aggregate voting power
of the Common Stock and Series D Preferred Stock outstanding.


<PAGE>



                                  SCHEDULE 13D

         This Amendment No. 12 amends and supplements the following items of the
Reporting  Persons'  Statement on Schedule  13D,  dated  February  24, 1997,  as
amended to date (the "Schedule").

Item 3.  Source and Amount of Funds or Other Consideration

         The  information  contained in Item 3 to the Schedule is hereby amended
by adding the following:

         Between  December 29, 1998 and February 8, 1999,  Aries Trust and Aries
Domestic used their  respective  general  funds to purchase  306,100 and 428,300
shares of Common Stock (additional "Purchased Common Stock"),  respectively,  on
the open market.

                  Aries Trust made the following purchases:

Date                       No. of Shares             Sales Price

12/29/98                   46,500                    $1.207
1/12/98                    16,200                    $1.553
1/13/98                    26,200                    $1.625
1/14/98                    26,200                    $1.702
1/15/98                     5,000                    $1.938
1/20/98                     6,000                    $2.250
1/22/98                    20,000                    $2.000
1/25/98                    20,000                    $2.438
1/26/98                    20,000                    $2.445
1/27/98                    20,000                    $2.328
1/28/98                    20,000                    $2.359
1/29/98                    20,000                    $2.438
2/1/98                     20,000                    $2.484

                  Aries Domestic made the following purchases:

Date                       No. of Shares             Sales Price

12/29/98                   16,400                    $1.207
12/30/98                   30,000                    $1.240
12/31/98                   62,900                    $1.281
1/4/98                     65,700                    $1.313
1/5/98                     65,700                    $1.281
1/6/98                     65,700                    $1.370
1/7/98                     30,000                    $1.375
1/8/98                     65,700                    $1.375
1/11/98                    26,200                    $1.500


                               Page 8 of 11 Pages


<PAGE>




         In  addition,  on  January  7,  1999,  Aries  Trust and Aries  Domestic
purchased an aggregate of 15,000 shares of Series A Preferred Stock in a private
placement.  Aries Trust used  $95,221.88 of its general funds to acquire  10,500
shares of Series A Preferred  Stock,  which are convertible  into  approximately
76,179 shares of Common Stock and Aries Domestic used  $40,809.38 of its general
funds to acquire 4,500 shares of Series A Preferred Stock, which are convertible
into approximately 32,648 shares of Common Stock.

         Furthermore,  on  January  26,  1999,  Aries  Trust and Aries  Domestic
purchased an aggregate of 8,000 shares of Series A Preferred  Stock in a private
placement.  Aries Trust used  $35,549.50  of its general  funds to acquire 5,600
shares of Series A Preferred  Stock,  which are convertible  into  approximately
40,629 shares of Common Stock and Aries Domestic used  $15,235.50 of its general
funds to acquire 2,400 shares of Series A Preferred Stock, which are convertible
into approximately 17,412 shares of Common Stock.

         The Filing  Persons  disclaim  beneficial  ownership  of all the Common
Stock  except the  Purchased  Common  Stock.  Mr.  Weiss,  Hawkins and the Aries
Reporting Persons each disclaim  beneficial  ownership of the securities held by
each other.


Item 5.  Interest in Securities of Issuer.

         The  information  contained in Item 5 to the Schedule is hereby amended
and supplemented to read as follows:

     (a)  As of February 8, 1998:  Dr.  Rosenwald,  as the sole  shareholder  of
          Paramount Capital and as the holder of Placement Warrants and Advisory
          Warrants, may be deemed beneficially to own 22,102,609 shares or 69.7%
          of  the  Issuer's  Common  Stock;   Paramount  Capital,   through  the
          acquisitions of securities by Aries Trust and Aries  Domestic,  may be
          deemed  beneficially to own 19,236,216 shares or 66.7% of the Issuer's
          Common Stock;  and Mr. Weiss, as Managing Member of Hawkins and as the
          holder of securities of the Issuer, may be deemed  beneficially to own
          675,064 shares or 5.1% of the Issuer's  Common Stock.  Aries Domestic,
          Aries  Trust  and  Hawkins  may be  deemed  beneficially  to  own  the
          following numbers of shares of Common Stock:

          Aries Domestic                           6,564,464
          Aries Trust                             12,671,751
          Hawkins                                    526,737

          Pursuant to Rule 13d-4 promulgated  under the Securities  Exchange Act
          of 1934, as amended,  the Filing Persons disclaim beneficial ownership
          of all the Common Stock except the Purchased Common Stock. Pursuant to
          Rule 13d-4 promulgated  under the Securities  Exchange Act of 1934, as
          amended,  the Aries  Reporting  Persons,  Mr.  Weiss and Hawkins  each
          disclaim beneficial ownership of the securities held by each other.


                               Page 9 of 11 Pages

<PAGE>



          The  outstanding  shares of Series D Preferred Stock of the Issuer are
          entitled  to vote  together  with the  holders of Common  Stock on all
          matters  submitted  to a vote of  stockholders  of the  Issuer.  As of
          December 28, 1998, Dr.  Rosenwald,  Paramount  Capital and Aries Trust
          may be deemed  beneficially  to own  (within the meaning of Rule 13d-3
          under the Securities  Exchange Act of 1934, as amended)  53.6%,  50.2%
          and 35.6%,  respectively,  of the aggregate voting power of the Common
          Stock and Series D Preferred Stock outstanding.

     (b)  Dr.  Rosenwald  and  Paramount  Capital  share the power to vote or to
          direct the vote and to dispose or to direct the  disposition  of those
          shares owned by each of Aries Domestic and Aries Trust.  Dr. Rosenwald
          has the sole  power to vote or to direct the vote and to dispose or to
          direct the disposition of the shares underlying the Placement Warrants
          and Advisory  Warrants  held by him.  Mr. Weiss and Hawkins  share the
          power to vote or to direct  the vote and to  dispose  or to direct the
          disposition  of the shares  owned by Hawkins.  Mr.  Weiss has the sole
          power to vote or to direct  the vote and to  dispose  or to direct the
          disposition of the shares that he owns.

     (c)  Other than certain of the open market and private placement  purchases
          of Common  Stock  reported in Item 3, the  Reporting  Persons have not
          engaged in any  transactions  in the Common Stock of the Issuer in the
          past 60 days.

     (d)&(e) Not applicable.

                               Page 10 of 11 Pages


<PAGE>



                                   SIGNATURES
                                   ----------

               After reasonable  inquiry and to the best knowledge and belief of
the undersigned,  the undersigned certify that the information set forth in this
statement is true, complete and correct.

                                    PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  February 9, 1999
        New York, NY             By:
                                     -------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman



                                    ARIES DOMESTIC FUND, L.P.
                                    By: Paramount Capital Asset Management, Inc.
                                          General Partner

Dated:  February 9, 1999
        New York, NY             By: /s/ Lindsay A. Rosenwald
                                     -------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman



                                    THE ARIES TRUST
                                    By: Paramount Capital Asset Management, Inc.
                                    Investment Manager

Dated:  February 9, 1999
        New York, NY             By: /s/ Lindsay A. Rosenwald
                                     -------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     Chairman



Dated:  February 9, 1999
        New York, NY             /s/ Lindsay A. Rosenwald
                                 ---------------------------------
                                 Lindsay A. Rosenwald, M.D.



Dated:  February 9, 1999
        New York, NY             /s/ Mr. Michael S. Weiss
                                 ---------------------------------
                                 Mr. Michael S. Weiss



                                    HAWKINS GROUP, LLC

Dated:  February 9, 1999
        New York, NY         By:  /s/ Mr. Michael S. Weiss
                                  ---------------------------------
                                  Mr. Michael S. Weiss
                                  Managing member


                               Page 11 of 11 Pages





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