GENTA INCORPORATED /DE/
10-Q, 1999-05-17
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 10-Q

                                   (Mark One)

             [X]   QUARTERLY REPORT UNDER SECTION 13 OR 15 (d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                  For the quarterly period ended March 31, 1999

                                       OR

             [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                         Commission File Number 0-19635


                               GENTA INCORPORATED
   (Exact name of Registrant as specified in its certificate of incorporation)

                   Delaware                                33-0326866        
       (State or other jurisdiction of                  (I.R.S. Employer     
        incorporation or organization)               Identification Number)  
                                                                      
                                           
        99 Hayden Avenue, Suite 200
          Lexington, Massachusetts                         02421-7966     
 (Address of principal executive offices)                  (Zip Code)     


                                 (781) 860-5150
              (Registrant's telephone number, including area code)


     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. 

                         Yes _X_                  No ___

     As of May 3, 1999, the  registrant  had  15,401,275  shares of common stock
outstanding.


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<PAGE>

                               Genta Incorporated
                               INDEX TO FORM 10-Q



PART I.  FINANCIAL INFORMATION                                              Page
                                                                            ----
Item 1.  Financial Statements (Unaudited)

            Condensed Consolidated Balance Sheets at December 31, 1998
                     and March 31, 1999                                       3

            Condensed Consolidated Statements of Operations for the
                     Three  Months Ended March 31, 1998 and 1999              4

            Condensed Consolidated Statements of Cash Flows for the
                     Three Months Ended March 31, 1998 and 1999               5

            Notes to Condensed Consolidated Financial Statements              6

Item 2.  Management's Discussion and Analysis of Financial Condition
                  and Results of Operations                                   9


PART II. OTHER INFORMATION

Item 1.  Legal Proceedings                                                   22

Item 6.  Exhibits and Reports on Form 8-K                                    23



SIGNATURES                                                                   24



                                        2

<PAGE>



                               Genta Incorporated
                      CONDENSED CONSOLIDATED BALANCE SHEETS
                                   (UNAUDITED)

<TABLE>
<CAPTION>
                                                                                  December 31,        March 31,
                                                                                 ------------------------------
                                     ASSETS                                           1998             1999
                                                                                 ------------------------------
<S>                                                                              <C>              <C>
Current assets:
   Cash and cash equivalents .................................................   $   1,566,288    $     638,990
   Short term investments ....................................................         892,372             --
   Other receivables .........................................................            --            261,000
   Prepaid expenses ..........................................................         405,700          177,515
   Property held for sale ....................................................         290,000             --
   Other current assets ......................................................         176,700          437,492
   Net current assets of discontinued operations .............................       2,606,304        2,536,846
                                                                                 ------------------------------
Total current assets .........................................................       5,937,364        4,051,843
                                                                                 ------------------------------
Property and equipment, net ..................................................         148,245           27,799
Intangibles, net .............................................................       1,460,383        1,360,824
Deposits and other assets ....................................................           5,301            6,501
                                                                                 ------------------------------
Total assets .................................................................   $   7,551,293    $   5,446,967
                                                                                 ==============================

                      LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
   Accounts payable ..........................................................   $     432,116    $     359,863
   Payable to research institutions ..........................................         635,661          635,661
   Accrued compensation ......................................................          84,888          137,076
   Other accrued expenses ....................................................         580,779          779,450
   Net liabilities of liquidated foreign subsidiary ..........................         574,812          574,812
                                                                                 ------------------------------
Total current liabilities ....................................................       2,308,256        2,486,862
                                                                                 ------------------------------

Deficit in joint venture .....................................................       2,284,018             --
Stockholders' equity:
   Preferred stock; 5,000,000 shares authorized, convertible
     preferred shares outstanding:
     Series A convertible preferred stock, $.001 par value;
       447,600 and 429,600 shares issued and outstanding at
       December 31, 1998 and March 31, 1999, respectively, liquidation
       value is $25,776,000 at March 31, 1999 ................................             448              430
     Series D convertible preferred stock, $.001 par value; 186,021 and 144,341
       shares issued and outstanding at December 31, 1998 and March 31, 1999,
       respectively; liquidation value is $20,207,740 at March 31, 1999 ......             186              144
   Common stock, $.001 par value; 70,000,000 shares authorized;
     10,426,215 and 15,030,423 shares issued and outstanding at
     December 31, 1998 and March 31, 1999, respectively ......................          10,426           15,030
   Additional paid-in capital ................................................     130,627,251      131,594,944
   Accumulated deficit .......................................................    (132,053,657)    (132,258,847)
   Accrued dividends payable .................................................       5,108,790        5,271,199
   Deferred compensation .....................................................        (734,425)      (1,662,795)
                                                                                 ------------------------------
Total stockholders' equity ...................................................       2,959,019        2,960,105
                                                                                 ------------------------------
Total liabilities and stockholders' equity ...................................   $   7,551,293    $   5,446,967
                                                                                 ==============================
</TABLE>

                            See accompanying notes.
                                        3

<PAGE>



                               Genta Incorporated
                 CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                                   (Unaudited)


                                                   Three Months Ended March 31,
                                                  -----------------------------
                                                      1998             1999
                                                  ------------     ------------
                                                   (restated)
Revenues:
   Collaborative research and development ....    $     17,396     $       --
                                                  ------------     ------------
                                                        17,396             --

Cost and expenses:
   Research and development ..................         813,691        1,089,966
   General and administrative ................         995,723        1,112,412
                                                  ------------     ------------
                                                     1,809,414        2,202,378
                                                  ------------     ------------
Loss from operations .........................      (1,792,018)      (2,202,378)
Equity in net (loss) income of
  joint venture ..............................        (155,744)       2,284,018
Other income (expense):
   Interest income ...........................          85,767           51,864
   Interest expense ..........................          (3,430)            (173)
   Other expense .............................            --           (149,114)
                                                  ------------     ------------
Net loss from continuing operations ..........      (1,865,425)         (15,783)
Income (loss) from discontinued operations ...         103,060         (189,407)
                                                  ------------     ------------
Net loss .....................................      (1,762,365)        (205,190)
Dividends accrued on preferred stock .........            --           (342,409)
                                                  ============     ============
Net loss applicable to common shares .........    $ (1,762,365)    $   (547,599)
                                                  ============     ============
Net (loss) income per share
  Continuing operations ......................    $      (0.33)    $      (0.03)
  Discontinued operations ....................            0.02            (0.01)
                                                  ------------     ------------
Net loss per common share ....................    $      (0.31)    $      (0.04)
                                                  ============     ============
Shares used in computing net
  loss per common share ......................       5,727,035       12,902,237
                                                  ============     ============


                            See accompanying notes.
                                        4

<PAGE>


                               Genta Incorporated
                 CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                   (Unaudited)

<TABLE>
<CAPTION>

                                                                 Three Months Ended March 31,
                                                                 ---------------------------
                                                                    1998           1999
                                                                 -----------    -----------
                                                                  (restated)
<S>                                                              <C>            <C>         
Operating activities
Net loss .....................................................   $(1,762,365)   $  (205,190)
Items reflected in net loss not requiring cash:           
   Depreciation and amortization .............................       289,782        259,862
   Equity in net loss (gain) of joint venture ................       155,744     (2,284,018)
   Compensation expense related to stock options .............          --           76,134
   Loss on sale of fixed assets ..............................          --          149,026
Changes in operating assets and liabilities ..................      (295,783)       218,286
                                                                 -----------    -----------
Net cash used in operating activities ........................    (1,612,622)    (1,785,900)

Investing activities
Maturities of short-term investments .........................       873,039        892,372
Purchase of property and equipment ...........................          --          (24,551)
Sale of property and equipment ...............................          --            5,087
Purchase of intangibles ......................................          --          (99,635)
Investment in and advances to joint venture ..................        (9,665)          --
Deposits and other ...........................................          --           (1,200)
                                                                 -----------    -----------
Net cash provided by investing activities ....................       863,374        772,073

Financing activities
Issuance of common stock upon exercise of warrants ...........          --           35,391
Proceeds from equipment conversion to lease ..................          --           60,085
Other ........................................................          --             --
                                                                 -----------    -----------
Net cash provided by financing activities ....................          --           95,476
                                                                 -----------    -----------
Increase/(Decrease) in cash and cash equivalents .............      (749,248)      (918,351)
Less cash at liqidated foreign subsidiary ....................          --           (8,947)
Cash and cash equivalents at beginning of period .............     1,202,668      1,566,288
                                                                 -----------    -----------
Cash and cash equivalents at end of period ...................   $   453,420    $   638,990
                                                                 ===========    ===========

Supplemental disclosures of cash flow information:
Interest paid ................................................   $     3,430    $       173
Supplemental schedule of noncash investing and
  financing activities:
Preferred stock dividends accrued ............................          --          342,409
Common stock issued in payment of dividends on preferred stock          --           18,597
</TABLE>


                            See accompanying notes.
                                        5

<PAGE>



                               Genta Incorporated
              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                                 March 31, 1999
                                   (Unaudited)


(1)  Basis of Presentation

     The  unaudited  condensed   consolidated   financial  statements  of  Genta
Incorporated, a Delaware corporation (the "Company"), presented herein have been
prepared in accordance with generally accepted accounting principles for interim
financial information and with the instructions to Form 10-Q. Accordingly,  they
do not  include  all of the  information  and note  disclosures  required  to be
presented  for  complete  financial  statements.   The  accompanying   financial
statements  reflect  all  adjustments   (consisting  only  of  normal  recurring
accruals)  which  are,  in  the  opinion  of  management,  necessary  for a fair
presentation of the results for the interim periods presented.  Certain balances
in 1998  have  been  reclassified  to  conform  with the  presentation  in 1999.
Research and development and general and  administrative  expenses were restated
for the three months ended March 31, 1998 to properly  reflect  amortization and
depreciation expense. Also, equity in net loss of joint venture was restated for
the three months ended March 31, 1998.

     These unaudited  condensed  consolidated  financial  statements and related
disclosures  have been prepared with the  presumption  that users of the interim
financial  information  have  read  or  have  access  to the  audited  financial
statements  for  the  preceding  fiscal  year.   Accordingly,   these  financial
statements should be read in conjunction with the audited consolidated financial
statements and the related notes thereto included in the Company's Annual Report
on Form 10-K for the fiscal year ended  December 31, 1998, as amended (the "1998
Form 10-K").

     The Company has experienced significant quarterly fluctuations in operating
results and it expects that these fluctuations in revenues,  expenses and losses
will  continue,  although, as a  result  of  the  sale  of the  business  of JBL
Scientific,  Inc. ("JBL"),  a subsidiary of the Company which was engaged in the
specialty chemicals business, revenues are expected to decrease.

(2)  Discontinued Operations

     On March 19, 1999,  the Company  entered into an Asset  Purchase  Agreement
with  Promega  Corporation  ("Promega"),  whereby a wholly owned  subsidiary  of
Promega acquired substantially all of the assets and assumed certain liabilities
of JBL for approximately  $5.0 million in cash,  including  $250,000 that may be
withheld  by Promega  while the closing  balance  sheet of JBL is  evaluated,  a
promissory   note  for  $1.2  millon   maturing   in  June  2000,   and  certain
pharmaceutical  development  services  in support of the  Company's  development
activities.  The  purchase  price may be reduced  as a result of a  post-closing
audit of JBL's  balance  sheet as at the closing  date (which  would result in a
dollar-for-dollar  reduction  of the  purchase  price to the extent that the net
book value of the  purchased  assets is less than  $1,768,000)  adjustments  and
indemnification obligations.

     As a  result  of the  sale  of  JBL's  business,  the  Company's  specialty
biochemical  manufacturing  segment  (JBL) has been  presented  as  discontinued
operations.  The assets and liabilities relating to the discontinued  operations
are  included  in net  assets of  discontinued  operations  in the  consolidated
balance  sheets at  December  31,  1998 and  March  31,  1999.  The  results  of
operations for the discontinued segment are included in discontinued  operations
in the  consolidated  statements of operations  for the three months ended March
31,  1998 and 1999  (any  loss  incurred  from  March  19,  1999 was  considered
immaterial).  In  connection  with the sale of JBL's  business and pursuant to a
lease  termination  agreement,  the  Company  granted  stock  options to acquire
450,000 shares of the Company's common stock, par value $.001 per share ("Common
Stock"),  to the owners of the building  previously leased to JBL. Those options
will  be  accounted  for  pursuant  to  guidelines  in  Statement  of  Financial
Accounting   Standards   ("SFAS")   No.   123,   "Accounting   for   Stock-Based
Compensation,"  using the Black-Scholes  method and have an approximate value of
$1.1  million  which will be  charged  against  the gain on the sale of JBL.  In
addition,  there were 252,300  options  granted to the employees of JBL upon the
closing of the sale of JBL in  connection  with an ongoing  service  arrangement
between Promega and the Company, which will be accounted for under variable plan
accounting pursuant to SFAS No. 123 and the Black-


                                        6

<PAGE>



Scholes  guidelines.  The  estimated  value of these  options will be charged to
Research and Development  expense until the vesting date, which will be no later
than one year from the closing date of the sale.

     The  closing  of the  sale of JBL was  completed  on May 10,  1999  with an
estimated  gain on the  sale of  approximately  $1.5  million,  based  upon  the
purchase price of JBL less its net assets and costs and expenses associated with
the sale.  Because the Company is  continuing to evaluate the costs and expenses
associated with the sale of JBL, the gain on the sale is subject to change.

     Net current assets of discontinued operations consisted of the following:

                                        December 31, 1998       March 31, 1999
                                        -----------------       --------------
Accounts receivable, net ............     $   832,018             $   494,859
Inventories, net ....................         963,611                 971,573
Property and equipment, net .........         763,082                 626,681
Other assets ........................         897,399                 958,034
Liabilities .........................        (849,806)               (514,301)
                                          -----------             -----------
         Total ......................     $ 2,606,304             $ 2,536,846
                                          ===========             ===========

     Operating results of the discontinued segment consisted of the following:

                                                  Three Months Ended
                                                      March 31,
                                            ------------------------------
                                                1998               1999
                                            -----------        -----------
     Product sales ..................       $ 1,602,179        $ 1,273,598
     Operating expenses .............        (1,499,869)        (1,461,553)
     Other income (expense) .........               750             (1,452)
                                            -----------        -----------
     Income (loss) ..................       $   103,060        $  (189,407)
                                            ===========        ===========


     Three customers  accounted for an aggregate of approximately 37% and 39% of
product   sales  during  the  three  months  ended  March  31,  1998  and  1999,
respectively.  One other  customer,  who  accounted for less than 10% of product
sales in 1998, accounted for approximately 27% of product sales during the three
months ended March 31, 1999.

(3)  Net Loss Per Common Share

     Under SFAS No.  128,  "Earnings  per  Share,"  the  Company is  required to
present basic and diluted  earnings per share if applicable.  Basic earnings per
share  includes the weighted  average  number of shares  outstanding  during the
period.  Diluted  earnings per share  includes the  weighted  average  number of
shares  outstanding and gives effect to potentially  dilutive common shares such
as options, warrants and convertible debt and preferred stock outstanding.

     Net loss per common  share for the three  months  ended  March 31, 1998 and
1999 is  based  on the  weighted  average  number  of  shares  of  Common  Stock
outstanding  during the  periods.  Basic and diluted loss per share are the same
for all periods presented as potentially


                                        7

<PAGE>



dilutive  securities,  including  options,  warrants and  convertible  preferred
stock,  have not been  included  in the  calculation  of the net loss per common
share as their effect is antidilutive.

(4)  Stockholders' Equity

     During the three months ended March 31, 1999, an aggregate of 41,680 shares
of the Company's Series D Convertible Preferred Stock, par value $.001 per share
("Series D Preferred  Stock"),  were  converted at the option of the  respective
holders  thereof  into an  aggregate  of  4,436,118  shares of Common Stock at a
conversion  price of $0.94375 per share.  An  aggregate of 18,000  shares of the
Company's  Series A  Preferred  Stock,  par value  $.001 per  share  ("Series  A
Preferred  Stock"),  were  converted  at the option of the holders of the shares
into an  aggregate of 130,590  shares of Common  Stock at a conversion  price of
$8.27 per share.  An  aggregate  of 37,500  shares of Common  Stock were  issued
pursuant to warrant  exercises.  In addition to the option  grants  described in
Note 2 above, to the owners of the building  previously leased by JBL and to the
employees of JBL, options to acquire 675,000 shares of Common Stock were granted
to an employee of the  Company at an exercise  price below fair market  value at
the date of grant resulting in deferred compensation of approximately  $987,000.
This deferred compensation will be amortized over a period of four years.

     In 1999,  the Board of  Directors  of the Company  and  certain  holders of
Common Stock, Series A Preferred Stock and Series D Preferred Stock approved, in
accordance with Delaware law, an amendment to the Company's Restated Certificate
of  Incorporation  to remove the  "Fundamental  Change"  redemption  right.  The
Company  recently  distributed to its  stockholders an Information  Statement on
Form 14C  describing  this  stockholder  action  and has  formally  amended  the
Restated  Certificate of Incorporation after the expiration of the 20-day period
provided  for in Rule 14c-5  promulgated  under the  Securities  Exchange Act of
1934, as amended (the "Exchange Act").

(5)  Genta Jago

     On March 4, 1999,  the Company and  SkyePharma (on behalf of itself and its
affiliates)  entered  into an interim  agreement  (the  "Interim JV  Agreement")
pursuant to which the Company was released from all liability relating to unpaid
development  costs and  funding  obligations  of Genta Jago,  the joint  venture
between the Company and  SkyePharma.  SkyePharma  agreed to be  responsible  for
substantially  all the obligations of the joint venture to third parties and for
the further  development of the joint  venture's  products,  with any net income
resulting  therefrom  to be  allocated in  agreed-upon  percentages  between the
Company and  SkyePharma.  As a result of the Interim JV  Agreement,  the Company
wrote off its equity interest in the net loss of the joint venture and, as such,
recorded a gain of  approximately  $2.3 million for the three months ended March
31, 1999.

(6)  Legal Proceedings

     On June 4, 1998, the Company's  statutory  process agent received a Summons
and Complaint in a lawsuit brought by Johns Hopkins University ("Johns Hopkins")
against the  Company in  Maryland  Circuit  Court for  Baltimore  City (Case No.
98120110).  Johns Hopkins alleges in the Complaint that the Company has breached
the Johns  Hopkins  Agreement  and owes it  licensing  royalty  fees and related
expenses in the amount of $308,832.  Johns Hopkins also alleges the existence of
a separate March 1993 letter  agreement  wherein the Company agreed to support a
fellowship  program at the Johns Hopkins School of Hygiene and Public Health and
the Company's breach thereof,  with damages of $326,829. On August 10, 1998, the
Company's  statutory process agent received a Summons and Complaint in a related
lawsuit brought by the Ts'o/Miller Partnership and others against the Company in
the same court (Case No. 98182113).  The Ts'o/Miller  Partnership claims that it
is owed  licensing  royalty  fees in the  amount of  $287,671.  The  Company  is
currently  in  settlement  negotiations.  The Company  believes  that no further
accrual should be necessary in connection with this settlement.

     In October 1996, JBL retained a chemical  consulting firm to advise it with
respect to an  incident of soil and  groundwater  contamination  (the  "Spill").
Sampling  conducted at the JBL facility  revealed the presence of chloroform and
perchloroethylenes  ("PCEs")  in the  soil  and  groundwater  at  this  site.  A
quarterly  groundwater   monitoring  program  is  being  conducted,   under  the
supervision  of the  California  Regional  Water  Quality  Control Board for the
purposes of determining whether the levels of chloroform and PCEs have


                                        8

<PAGE>



decreased over time. The results of the latest sampling conducted show that PCEs
and  chloroform  have  decreased  in all but one of the  monitoring  sites.  The
Company has agreed to indemnify  Promega in respect of this matter.  The Company
believes that any costs stemming from further  investigating or remediating this
contamination  will not have a material  adverse  effect on the  business of the
Company, although there can be no assurance thereof.

     JBL received notice on October 16, 1998 from Region IX of the Environmental
Protection  Agency  (the  "EPA") that it had been  identified  as a  potentially
responsible  party ("PRP") at the Casmalia  Disposal  Site,  which is located in
Santa Barbara,  California.  JBL has been  designated as a de minimis PRP by the
EPA. The EPA currently  estimates that de minimis PRPs will be require to pay as
little as $75,000 and as much as $750,000 to settle their  potential  liability,
depending upon the volume of wastes  attributed to them. The Company received an
estimated volume calculation from the EPA, and a response,  which is due on June
9, 1999,  is currently  under review.  While the terms of a settlement  have not
been finalized, they should contain standard contribution protection and release
language. The Company has accrued $75,000 during 1998. The Company believes that
any costs stemming from further  investigating or remediating this contamination
will not have a material adverse effect on the business of the Company, although
there can be no assurance  thereof.  The Company has agreed to indemnify Promega
in respect of this matter.

Item 2. Management's Discussion and Analysis of Financial Condition and Results
        of Operations

Overview

     Since its inception in February 1988, the Company has devoted its principal
efforts toward drug discovery,  research and  development.  The Company has been
unprofitable  to  date  and,  even  if it  obtains  financing  to  continue  its
operations,  expects to incur substantial  operating losses for the next several
years  due to  continued  requirements  for  ongoing  research  and  development
activities,   preclinical  and  clinical  testing  activities,   and  regulatory
activities, and for the possible establishment of manufacturing activities and a
sales and marketing  organization.  From the period since its inception to March
31, 1999, the Company has incurred a cumulative net loss of approximately $132.3
million.  The Company has  experienced  significant  quarterly  fluctuations  in
operating results and it expects that these  fluctuations in revenues,  expenses
and losses will continue,  although,  as a result of the sale of JBL's business,
revenues are expected to decrease.

     The unaudited condensed consolidated financial statements contained in this
Quarterly  Report  on Form  10-Q  that are not  historical  are  forward-looking
statements  within the meaning of Section 27A of the  Securities Act of 1933, as
amended (the "Securities  Act"), and Section 21E of the Exchange Act,  including
statements  regarding  the  expectations,   beliefs,  intentions  or  strategies
regarding the future. The Company intends that all forward-looking statements be
subject to the  safe-harbor  provisions  of the  Private  Securities  Litigation
Reform Act of 1995. These forward-looking statements reflect the Company's views
as of the date  they are made  with  respect  to  future  events  and  financial
performance, but are subject to many risks and uncertainties,  which could cause
the actual results of the Company to differ  materially  from any future results
expressed or implied by such forward-looking statements.  Examples of such risks
and  uncertainties  include,  but  are  not  limited  to,  obtaining  sufficient
financing to maintain the Company's planned  operations,  the timely development
and receipt of necessary  regulatory  approvals and  acceptance of new products,
the successful  application of the Company's technology to produce new products,
the obtaining of proprietary  protection  for any such  technology and products,
the impact of  competitive  products  and  pricing and  reimbursement  policies,
changing  market  conditions  and the other risks detailed in the Certain Trends
and  Uncertainties  section of this  Management's  Discussion  and  Analysis  of
Financial  Condition  and Results of  Operations  ("MD&A") and elsewhere in this
Quarterly  Report on Form 10-Q.  The Company  does not  undertake  to update any
forward-looking statements.

Results of Operations

     The following  discussion of results of operations relates to the Company's
continuing business.

     Operating  revenues  totaled  $17,396 for the three  months ended March 31,
1998 and  decreased to $0 for the same period in 1999.  The changes in operating
revenue have largely reflected the Company's lessened


                                        9

<PAGE>



involvement in Genta Jago development activities. The expenses relating to these
revenues are  recognized  as Costs and Expenses in the same period such that the
net effect on the  Company's  consolidated  financial  statements  is zero.  The
Company has reduced the breadth of its activities and focused its  resources  on
development of its lead AnticodeTM oligonucleotide, G3139.

     On March 19, 1999,  the Company  entered into an Asset  Purchase  Agreement
with  Promega,   whereby  a   wholly-owned   subsidiary   of  Promega   acquired
substantially all of the assets and assumed certain liabilities of JBL for cash,
a promissory note and certain pharmaceutical  development services in support of
the Company's development  activities.  See Note 2 to the Company's consolidated
financial  statements.  The sale of the assets of JBL was  completed  on May 10,
1999, and will result in a significant  decrease in ongoing revenues,  as all of
the Company's product sales have been attributable to JBL.

     Costs and expenses totaled  approximately  $1.8 million in the three months
ended March 31, 1998, and increased to  approximately  $2.2 million for the same
period in 1999.  Primarily,  the overall  increase  reflects greater activity in
clinical trials along with an increase in general and  administrative  for legal
and consulting expenses.

     Research and development expenses totaled approximately $0.8 million in the
three months ended March 31, 1998, and increased to  approximately  $1.1 million
for the same period in 1999. The increase in research and  development  expenses
is primarily  attributable to the cost associated with clinical trials including
related drug  supplies.  During the three months ended March 31, 1999,  $748,000
was recorded for clinical trials and for related drug supplies.

     It is anticipated  that research and  development  expenses may increase in
the  future,   assuming  the  Company  obtains  sufficient  financing,   as  the
development  program for G3139 expands and more patients are treated in clinical
trials at  higher  doses,  through  longer or more  treatment  cycles,  or both.
Furthermore,  the  Company  is  pursuing  other  opportunities  for new  product
development  candidates which, if successful,  will require additional  research
and development  expenses.  There can be no assurance,  however, that the trials
will  proceed in this manner or that the Company will  initiate new  development
programs.

     General and administrative expenses were approximately $1.0 million for the
three months ended March 31,  1998,  and  increased to $1.1 million for the same
period  in 1999.  The  increase  reflects  higher  legal  and  consulting  costs
associated  with  the  Company's   filings  with  the  Securities  and  Exchange
Commission  (the  "SEC") and  the costs  associated  with the relocation  of its
headquarters from California to Massachusetts.

     On March 4, 1999,  the Company and  SkyePharma (on behalf of itself and its
affiliates)  entered into the Interim JV Agreement pursuant to which the Company
was released from all liability relating to unpaid development costs and funding
obligations of Genta Jago, the joint venture between the Company and SkyePharma.
SkyePharma agreed to be responsible for substantially all the obligations of the
joint  venture to third  parties  and for the further  development  of the joint
venture's  products,  with any net income resulting therefrom to be allocated in
agreed-upon  percentages between the Company and SkyePharma.  As a result of the
Interim JV Agreement,  the Company wrote off its equity interest in the net loss
of the joint venture and, as such, recorded income of approximately $2.3 million
for the three months ended March 31, 1999.

     Other  expenses  include a loss on the sale of fixed  assets as a result of
the headquarter relocation.

     The Company's net loss from continuing  operations before accrued dividends
totaled approximately $0.02 million, or $0.00 per share of Common Stock, for the
three  months  ended  March 31,  1999  compared  to a net loss  from  continuing
operations of  approximately  $1.9 million,  or $0.33 per share of Common Stock,
for the same period in 1998.  During the three months ended March 31, 1999, as a
result of accrued  dividends on the Company's  preferred stock of  approximately
$0.34 million and a loss from  discontinued  operations of  approximately  $0.19
million the  Company's  net loss per common share was $0.04.  The  Company's net
loss for the three months ended March 31, 1999 was lower than those reported for
the comparable  period of 1998  primarily as a result of recording  nonrecurring
income of approximately  $2.3 million relating to its equity interest in the net
loss of the joint venture.



                                       10

<PAGE>



     Since the  formation  of Genta  Jago,  no products  have been  successfully
developed and marketed. Since the initial plans called for earlier introductions
and since there have been significant  changes in the market  environment  since
the Company entered into the joint venture,  there is reason to believe that any
products that may be marketed in the future could represent significantly poorer
financial  opportunities  than those that were anticipated in the earlier plans.
This  reduction  in  opportunity  derives  from  factors such as the presence of
direct  competitors  to Genta Jago's  products being in the  marketplace  before
Genta Jago, and increasing  pricing pressures on  pharmaceuticals,  particularly
multisource or generic products,  from payors such as reimbursers and government
buyers. On May 20, 1998, Genta Jago received notice from Apothecon that they had
terminated the agreement for the  development of  ketoprofen.  Apothecon  stated
that their decision to terminate was based on the facts that a competing generic
is already being  successfully  marketed,  other competitors  already have ANDAs
pending for their own generic  formulations  of such drug and they  consider the
GEOMATRIX(R)  capsule  size  competitively  disadvantageous.  These  factors may
adversely affect Genta Jago even if it is successful in developing products that
obtain  regulatory  approval.  As a result and in consideration of the Company's
need to reduce expenses and focus its efforts,  the Company is seeking to direct
its resources away from the joint venture to its Anticode(TM)  drug development,
specifically G3139, for the immediate future. On July 27, 1998,  SkyePharma PLC,
the parent  company to SkyePharma,  announced  that an ANDA for naproxen  sodium
filed by Brightstone Pharma, its U.S. sales and marketing  subsidiary,  had been
accepted  for filing by the FDA.  Brightstone  has a license  from Genta Jago to
market this product.

     Interest income has fluctuated  significantly  each year and is anticipated
to  continue  to  fluctuate  primarily  due to  changes  in the  levels of cash,
investments and interest rates each period.

Liquidity and Capital Resources

     Since  inception,  the Company has financed its  operations  primarily from
private and public offerings of its equity securities.  Cash provided from these
offerings totaled  approximately $124.5 million through March 31, 1999. At March
31, 1999, the Company had cash,  cash  equivalents  and  short-term  investments
totaling  approximately  $0.6 million compared to approximately  $2.5 million at
December 31, 1998.

     The Company will need substantial  additional funds before it can expect to
realize significant  product revenue.  The Company projects that, at its current
rate of spending and for its current activities,  funds from the consummation of
the JBL sale and its existing cash funds will enable the Company to maintain its
present  operations  into the first  quarter  of 2000.  To the  extent  that the
Company is successful in accelerating  its  development of G3139,  expanding its
development  portfolio or acquiring or adding new  development  candidates,  the
current  cash  resources  will be consumed  at a greater  rate.  Similarly,  the
Company has recently hired additional  senior managers to direct the business of
the Company.  This will cause the rate of cash utilization to increase.  Certain
parties with whom the Company has agreements  have claimed  default and,  should
the Company be obligated to pay these claims or should the Company  engage legal
services to defend or negotiate its  positions or both,  its ability to continue
operations could be significantly reduced or shortened.  See "Certain Trends and
Uncertainties--Claims  of the Company's  Default Under Various  Agreements." The
Company anticipates that significant additional sources of financing,  including
equity  financings,  will be required  in order for the Company to continue  its
planned principal  operations.  The Company also anticipates  seeking additional
product development  opportunities from external sources.  Such acquisitions may
consume  cash  reserves  or require  additional  cash or equity.  The  Company's
working capital and additional  funding  requirements  will depend upon numerous
factors,  including:  (i) the progress of the Company's research and development
programs;  (ii) the  timing and  results of  preclinical  testing  and  clinical
trials;  (iii) the level of  resources  that the  Company  devotes  to sales and
marketing  capabilities;  (iv)  technological  advances;  (v) the  activities of
competitors;  and (vi) the  ability of the  Company to  establish  and  maintain
collaborative  arrangements with others to fund certain research and development
efforts, to conduct clinical trials, to obtain regulatory approvals and, if such
approvals are obtained, to manufacture and market products.  See "Certain Trends
and Uncertainties--Need for Additional Funds; Risk of Insolvency."

     If the Company  successfully  secures  sufficient  levels of  collaborative
revenues and other  sources of  financing,  it expects to use such  financing to
continue and expand its ongoing research and development activities,


                                       11

<PAGE>



preclinical and clinical testing  activities,  the  manufacturing  and/or market
introduction  of  potential   products  and  expansion  of  its   administrative
activities.

     In the first three months ended March 31, 1999, the holders of an aggregate
of 41,680  shares of Series D Preferred  Stock  converted  those  shares into an
aggregate of 4,436,118  shares of Common Stock,  and the holders of an aggregate
of 18,000  shares of Series A Preferred  Stock  converted  those  shares into an
aggregate of 130,590 shares of Common Stock.

     As discussed in Note 2 to the Company's  consolidated financial statements,
the Company  entered into an Asset Purchase  Agreement with Promega on March 19,
1999.  Under the  agreement,  a  wholly-owned  subsidiary  of  Promega  acquired
substantially  all of the  assets and  assumed  certain  liabilities  of JBL for
approximately  $5.0 million in cash,  including $250,000 that may be withheld by
Promega  for  up to  sixty  days  while  the  closing  balance  sheet  of JBL is
evaluated,  a promissory note for $1.2 millon maturing in June 2000, and certain
pharmaceutical  development  services  in support of the  Company's  development
activities.  The  purchase  price may be reduced  as a result of a  post-closing
audit of JBL's  balance  sheet as at the closing  date (which  would result in a
dollar-for-dollar  reduction  of the  purchase  price to the extent that the net
book value of the purchased assets is less than $1,768,000) and  indemnification
obligations.

Impact of Year 2000

     Some older computer programs were written using two digits rather than four
to define  the  applicable  year.  As a result,  those  computer  programs  have
sensitive  software that recognizes a date using 00 as the year 1900 rather than
the year 2000 (the "Year 2000  Issue").  This  could  cause a system  failure or
miscalculations   causing  disruption  of  operations,   including  a  temporary
inability  to  process   transactions  or  engage  in  similar  normal  business
activities.

     The Company has completed its  assessment of whether it will have to modify
or replace  portions of its software so that its computer  systems will function
properly with respect to dates in the year 2000 and  thereafter.  The Company is
currently  implementing a plan to acquire and install new computer  hardware and
upgraded  software in its facilities that will  accommodate  dating beyond 1999.
The total year 2000  project cost is not expected to be material and is expected
to be  completed  not  later  than  October  31,  1999,  which  is  prior to any
anticipated impact on its operating systems.  The Company believes that with the
modifications to existing software and conversions to new software the Year 2000
Issue will not pose significant  operational  problems for its computer systems.
However,  if  such  modifications  and  conversions  are  not  made,  or are not
completed  timely,  the Year 2000 Issue could have a material  adverse effect on
the operations of the Company.

     The Company has initiated formal communications with all of its significant
suppliers to determine the extent to which the Company's  interface  systems are
vulnerable to the failure of those third-party  suppliers to remediate their own
Year 2000 Issues. If through such communication or otherwise the Company becomes
aware of any such  failure  and is not  satisfied  that  such  failure  is being
adequately  addressed,  it will  take  appropriate  steps  to  find  alternative
suppliers.  There is no assurance  that the systems of other  companies on which
the Company's systems rely will be timely converted and will not have a material
adverse effect on the Company's  systems.  The costs of the project and the date
on which the Company believes it will complete the Year 2000  modifications  are
based  on  management's  best  estimates,  which  were  derived  using  numerous
assumptions of future events,  including the continued  availability  of certain
resources and factors.  However,  there can be no assurance that these estimates
will  be  achieved  and  actual  results  could  differ  materially  from  those
anticipated.  Specific  factors  that  might  cause  such  material  differences
include,  but are not limited to, the availability and cost of personnel trained
in this area, the ability to locate and correct all relevant computer codes, and
similar uncertainties.

     It has  been  acknowledged  by  governmental  authorities  that  year  2000
problems have the  potential to disrupt  global  economies,  that no business is
immune from the potentially far-reaching effects of year 2000 problems, and that
it is difficult to predict with  certainty  what will happen after  December 31,
1999. Consequently,  it is possible that year 2000 problems will have a material
effect on the  Company's  business  even if the  Company  takes all  appropriate
measures to ensure that it and its key suppliers are year 2000 compliant.




                                       12

<PAGE>

Certain Trends and Uncertainties

     In addition to the other information  contained in this Quarterly Report on
Form 10-Q, the following factors should be considered carefully.

Need for Additional Funds; Risk of Insolvency

     The Company's operations to date have consumed substantial amounts of cash.
The Company's  independent  auditors have included an  explanatory  paragraph in
their  report to the 1998 Form 10-K with  respect  to the  Company's  ability to
continue as a going concern.  See "Liquidity and Capital preclinical  [Global]."
The Company  will need to raise  substantial  additional  funds to continue  its
operations  and conduct  the costly and  time-consuming  research,  pre-clinical
development and clinical trials necessary to bring its products to market and to
establish  production and marketing  capabilities.  The Company  intends to seek
additional  funding  through  public or  private  financings,  including  equity
financings,  and through  collaborative  arrangements or the sale of key assets.
Adequate funds for these purposes, whether obtained through financial markets or
collaborative  or other  arrangements  with  corporate  partners  or from  other
sources, may not be available when needed or on terms acceptable to the Company.
Insufficient  funds may require the Company:  to delay,  scale back or eliminate
some or all of its research and product development  programs;  to license third
parties  to  commercialize  products  or  technologies  that the  Company  would
otherwise  seek to develop  itself;  to sell itself to a third  party;  to cease
operations;  or to declare  bankruptcy.  The Company's future cash  requirements
will be affected by results of research and development, results of pre-clinical
studies and  bioequivalence  and clinical trials,  relationships  with corporate
collaborators,  changes in the focus and direction of the Company's research and
development  programs,  competitive  and  technological  advances,  the  FDA and
foreign regulatory processes, and other factors.

Loss History; Uncertainty of Future Profitability.

     The Company has been unprofitable to date, incurring  substantial operating
losses associated with ongoing research and development activities, pre-clinical
testing,  clinical trials,  manufacturing  activities and development activities
undertaken by Genta Jago. From the period since its inception to March 31, 1999,
the Company has incurred a cumulative net loss of approximately  $132.3 million.
The Company has  experienced  significant  quarterly  fluctuations  in operating
results and expects that these  fluctuations  in  revenues,  expenses and losses
will continue, although, as a result of the sale of JBL's business, revenues are
expected to decrease. See "Certain Trends and Uncertainties--Need for Additional
Funds; Risk of Insolvency."

Subordination of Common Stock to Series A Preferred Stock and Series D Preferred
Stock; Risk of Dilution; Anti-Dilution Adjustments.

     In the event of the liquidation,  dissolution or winding up of the Company,
the Common Stock is expressly  subordinate  to the  approximately  $25.8 million
preference of the 429,600 outstanding shares of Series A Preferred Stock and the
approximately  $20.2  million  preference of the 144,341  outstanding  shares of
Series D Preferred Stock (not including an additional  40,395 shares of Series D
Preferred Stock that are issuable upon exercise of certain warrants).  Dividends
may not be paid on the Common  Stock  unless full  cumulative  dividends  on the
Series A Preferred  Stock and Series D  Preferred  Stock have been paid or funds
have been set aside, for such preferred dividends by the Company.

     The  conversion  rate  of the  Series  A  Preferred  Stock  is  subject  to
adjustment,  among other  things,  upon  certain  issuances  of Common  Stock or
securities  convertible into Common Stock at $67.50 per share or less. As of May
10,  1999,  each  share  of  Series  A  Preferred  Stock  is  convertible   into
approximately  7.430 shares of Common  Stock at a conversion  price of $8.08 per
share.  Each share of Series D Preferred  Stock is  presently  convertible  into
approximately  106 shares of Common Stock at a conversion  price of $0.94375 per
share of  Common  Stock,  and the  exercise  price of the  Class D  Warrants  is
presently  $0.94375  per share.  The  conversion  rate of the Series D Preferred
Stock and the exercise price of the Series D Warrants are subject to adjustment,
among  other  things,  upon  certain  issuances  of Common  Stock or  securities
convertible  into Common Stock at prices per share below certain  levels.  There
are 1,578,300 Class D Warrants  outstanding and another 201,975 Class D Warrants
issuable  upon the  exercise  of certain  warrants.  Finally,  the  Company  has
outstanding  Bridge  Warrants to purchase an aggregate  of  6,357,616  shares of
Common Stock at an exercise price


                                       13

<PAGE>



of  $0.471875  per share,  Line of Credit  Warrants to purchase an  aggregate of
50,000  shares of Common  Stock at an  exercise  price of $2.50 per  share,  LBC
Warrants  to  purchase  an  aggregate  of 700,000  shares of Common  Stock at an
exercise  price of $0.52 per share,  warrants to purchase an aggregate of 95,768
shares of Common Stock at various exercise prices between  approximately $13 and
$21 per share,  134,238  outstanding  employee stock options under the Company's
Amended and Restated 1991 Stock Plan at various  exercise  prices  between $3.13
and $26.25 per share, and 5,681,263 outstanding employee stock options under the
Company's  1998 Stock  Incentive  Plan and  Non-Employee  Directors'  1998 stock
Option Plan at various  exercise  prices between $0.88 and $2.41 per share.  The
Note and Warrant Purchase  Agreement provides that a number of additional Bridge
Warrants  ("Penalty  Warrants")  equal to 1.5% of the number of Bridge  Warrants
then held by the  Aries  Funds  shall be issued to the Aries  Funds for each day
beyond 30 days after the final  closing of the  Private  Placement  that a shelf
registration  statement  covering the Common  Stock  underlying  the  securities
purchased  pursuant to the Note and Warrant Purchase Agreement is not filed with
the  SEC and for  each  day  beyond  210  days  after  the  closing  date of the
investment  contemplated  by the Note and Warrant  Purchase  Agreement that such
shelf  registration  statement is not declared effective by the SEC. The Company
filed such shelf  registration  statement with the SEC on September 9, 1997, but
such shelf registration statement has not been declared effective by the SEC. As
a result,  the Company could be obligated to issue Penalty Warrants to the Aries
Funds. The Aries Funds have not, to date,  requested that the Company issue such
Penalty  Warrants.  The  Company and the Aries  Funds are  currently  conducting
negotiations to determine whether, and to what extent,  Penalty Warrants will be
issued.

Claims of the Company's Default Under Various Agreements.

     On May 15,  1997,  Johns  Hopkins  University  ("Johns  Hopkins")  sent the
Company a letter  stating  that the license  agreement  entered into between the
Company  and Johns  Hopkins  in May 1990 (the  "Johns  Hopkins  Agreement")  was
terminated.  On November  26,  1997,  Drs.  Paul O.P.  Ts'o and Paul Miller (the
"Ts'o/Miller  Partnership")  sent the Company a letter claiming that the Company
was in  material  breach of the  February  1989  license  agreement  between the
Company  and the  Ts'o/Miller  Partnership  (the  "Ts'o/Miller  Agreement")  for
failing to pay royalties from 1995 through 1997. By letter dated April 28, 1998,
the  Ts'o/Miller  Partnership  advised the Company that it was  terminating  the
license  granted  pursuant to the  Ts'o/Miller  Agreement.  On June 4, 1998, the
Company's  statutory process agent received a Summons and Complaint in a lawsuit
brought by Johns  Hopkins  against  the Company in  Maryland  Circuit  Court for
Baltimore City (Case No. 98120110).  Johns Hopkins alleges in the Complaint that
the Company has  breached  the Johns  Hopkins  Agreement  and owes it  licensing
royalty fees and related expenses in the amount of $308,832.  Johns Hopkins also
alleges the  existence  of a separate  March 1993 letter  agreement  wherein the
Company  agreed to support a fellowship  program at the Johns Hopkins  School of
Hygiene and Public  Health and the  Company's  breach  thereof,  with damages of
$326,829.  On August 10, 1998, the Company's  statutory process agent received a
Summons  and  Complaint  in  a  related   lawsuit  brought  by  the  Ts'o/Miller
Partnership  and  others  against  the  Company  in the  same  court  (Case  No.
98182113).  The Ts'o/Miller Partnership claims that it is owed licensing royalty
fees  in the  amount  of  $287,671.  The  Company  is  currently  in  settlement
negotiations. See "Legal Proceedings."

     The French government agency ANVAR asserted, in a letter dated February 13,
1998, that Genta Europe was not in compliance with the ANVAR Agreement, and that
ANVAR might request the immediate repayment of such loan. On July 1, 1998, ANVAR
notified Genta Europe by letter of its claim that the Company remains liable for
4,187,423 FF (as of May 10, 1999, approximately $688,412) and is required to pay
this amount immediately. The Company is working with ANVAR to achieve a mutually
satisfactory  resolution;  however,  there  can  be no  assurance  that  such  a
resolution will be obtained. There can be no assurance that the Company will not
incur  material  costs in relation to these  terminations  and/or  assertions of
default or liability.

Early Stage of Development; Technological Uncertainty.

     The  Company  is at an early  stage of  development.  All of the  Company's
potential  therapeutic products are in research or development,  and no revenues
have  been  generated  from  therapeutic  product  sales.  To date,  most of the
Company's  resources  have been  dedicated  to  applying  molecular  biology and
medicinal  chemistry to the research and  development of potential  Anticode(TM)
pharmaceutical products based upon oligonucleotide technology. While the Company
has  demonstrated  the activity of  Anticode(TM)  oligonucleotide  technology in
model systems in


                                       14

<PAGE>



vitro and the activity of  antisense  technology  in animals and has  identified
compounds that the Company believes are worthy of additional  testing,  only one
of these potential Anticode(TM)  oligonucleotide products has begun to be tested
in humans, with such testing in its early stages. There can be no assurance that
the novel approach of  oligonucleotide  technology  will result in products that
will  receive  necessary   regulatory  approvals  or  that  will  be  successful
commercially.  Further,  results  obtained  in  pre-clinical  studies  or  early
clinical  investigations  or pilot  bioequivalence  trials  are not  necessarily
indicative  of results  that will be  obtained  in  pivotal  human  clinical  or
bioequivalence  trials.  There can be no assurance  that any of the Company's or
Genta Jago's potential products can be successfully developed.  Furthermore, the
Company's  products in research or development may prove to have undesirable and
unintended side effects or other characteristics that may prevent or limit their
commercial  use.  There can be no assurance  that any of the  Company's or Genta
Jago's  products  will  obtain  FDA  or  foreign  regulatory  approval  for  any
indication or that an approved  compound  would be capable of being  produced in
commercial quantities at reasonable costs and successfully  marketed.  Products,
if any,  resulting from the Company's or Genta Jago's  research and  development
programs are not expected to be  commercially  available  for a number of years.
Certain competitive products have already been filed with and/or approved by the
FDA.  See  "Certain  Trends  and  Uncertainties--Potential   Adverse  Effect  of
Technological Change and Competition."

Limited Availability of Net Operating Loss Carryforwards.

     At December 31, 1998,  the Company has federal and California net operating
loss   carryforwards   of   approximately   $82.0  million  and  $14.7  million,
respectively.  The  difference  between  the  federal  and  California  tax loss
carryforwards is primarily  attributable to the  capitalization  of research and
development   expenses  for  California  tax  purposes  and  the  fifty  percent
limitation on California loss carryforwards  prior to 1997. The federal tax loss
carryforwards   will  begin  expiring  in  2003,  unless  previously   utilized.
Approximately  $2.8  million  and  $0.5  million  of  the  California  tax  loss
carryforward  expired  during  1997  and  1998,  respectively,  and the  related
deferred  tax  asset  and  tax  loss  carryforward  amounts  have  been  reduced
accordingly.  The remaining California tax loss will continue to expire in 1999,
unless  utilized.  The  Company  also has federal and  California  research  and
development  tax  credit   carryforwards  of  $3.2  million  and  $1.3  million,
respectively, which will begin expiring in 2003, unless previously utilized.

     Federal and  California  tax laws limit the  utilization  of income tax net
operating loss and credit  carryforwards  that arise prior to certain cumulative
changes  in a  corporation's  ownership  resulting  in change of  control of the
Company.  The future annual use of net operating loss carryforwards and research
and  development  tax credits will be limited due to the ownership  changes that
occurred during 1990, 1991,  1993, 1996, 1997 and 1998.  Because of the decrease
in value of the Company's stock,  the ownership  changes which occurred in 1996,
1997 and 1998 will have a material  adverse  impact on the Company's  ability to
utilize these carryforwards.

Dividends.

     The Company has never paid cash  dividends on its Common Stock and does not
anticipate paying any such dividends in the foreseeable future. In addition, the
Company is restricted  from paying cash dividends on its Common Stock until such
time as all cumulative  dividends  have been paid on  outstanding  shares of its
Series A Preferred  Stock and Series D Preferred  Stock.  The Company  currently
intends  to  retain  its  earnings,  if  any,  after  payment  of  dividends  on
outstanding shares of Series A Preferred Stock and Series D Preferred Stock, for
the development of its business.

No Assurance of Regulatory Approval; Government Regulation.

     The FDA and comparable  agencies in foreign  countries  impose  substantial
premarket approval  requirements on the introduction of pharmaceutical  products
through lengthy and detailed  pre-clinical and clinical  testing  procedures and
other costly and time-consuming procedures.  Satisfaction of these requirements,
which  includes  demonstrating  to the  satisfaction  of  the  FDA  and  foreign
regulatory agencies that the product is both safe and effective, typically takes
several years or more  depending  upon the type,  complexity  and novelty of the
product. There can be no assurance that such testing will show any product to be
safe or efficacious or, in the case of certain of Genta Jago's  products,  to be
bioequivalent to a currently marketed pharmaceutical. Government regulation also


                                       15

<PAGE>



affects the manufacture and marketing of pharmaceutical  products. The effect of
government  regulation  may be to  delay  marketing  of any new  products  for a
considerable or indefinite  period of time, to impose costly procedures upon the
Company's or Genta Jago's  activities and to diminish any competitive  advantage
that the  Company or Genta  Jago may have  attained.  It may take  years  before
marketing approvals are obtained for the Company's or Genta Jago's products,  if
at all. There can be no assurance that FDA or other regulatory  approval for any
products  developed  by the  Company  or Genta  Jago will be granted on a timely
basis, if at all, or, if granted, that such approval will cover all the clinical
indications for which the Company or Genta Jago is seeking  approval or will not
sustain  significant  limitations  in  the  form  of  warnings,  precautions  or
contraindications  with respect to conditions of use.  Further,  with respect to
the reformulated versions of currently available pharmaceuticals being developed
through  Genta  Jago,  there is a  substantial  risk that the  manufacturers  or
marketers  of such  currently  available  pharmaceuticals  will seek to delay or
block regulatory approval of any reformulated  versions of such  pharmaceuticals
through  litigation  or other means.  Any  significant  delay in  obtaining,  or
failure  to  obtain,  such  approvals  could  materially  adversely  affect  the
Company's or Genta Jago's revenue.  Moreover,  additional  government regulation
from future legislation or administrative  action may be established which could
prevent or delay  regulatory  approval of the Company's or Genta Jago's products
or further  regulate the prices at which the Company's or Genta Jago's  proposed
products may be sold.

     The Company is also subject to various  foreign,  federal,  state and local
laws, regulations and recommendations  (collectively "Governmental Regulations")
relating to safe working conditions, laboratory and manufacturing practices, the
experimental  use of animals and the use,  manufacture,  storage,  handling  and
disposal of hazardous or potentially hazardous substances, including radioactive
compounds and infectious  disease agents,  used in connection with the Company's
research and development work and manufacturing  processes. In October 1996, JBL
retained a chemical  consulting firm to advise it with respect to an incident of
soil and groundwater contamination (the "Spill").  Sampling conducted at the JBL
facility  revealed  the  presence  of  chloroform  and  PCEs  in  the  soil  and
groundwater  at this site. Six soil borings were drilled and  groundwater  wells
were installed at several  locations  around the site. The Company has agreed to
indemnify Promega in respect of the matter.  The Company believes that the costs
associated with further  investigation  or remediation  will not have a material
adverse  effect  on  the  business  of the  Company,  although  there  can be no
assurance thereof.  The Company believes that it is in material  compliance with
Governmental  Regulations;  however,  there can be no assurance that the Company
will not be required  to incur  significant  costs to comply  with  Governmental
Regulations in the future.  See Note 6 to the Company's  consolidated  financial
statements.

     JBL received notice on October 16, 1998 from Region IX of the Environmental
Protection  Agency  ("EPA")  that  it  had  been  identified  as  a  potentially
responsible  party ("PRP") at the Casmalia  Disposal  Site,  which is located in
Santa Barbara,  California.  JBL has been  designated as a de minimis PRP by the
EPA. The EPA  currently  estimates  that the de minimis PRPs will be required to
pay as little as  $75,000  and as much as  $750,000  to settle  their  potential
liability, depending upon the volume of wastes attributed to them. On this basis
the Company  accrued $75,000 in 1998. The Company  received an estimated  volume
calculation  from  the EPA and a  response,  which  is due on June 9,  1999,  is
currently  under  review.  While  the  terms  of the  settlement  have  not been
finalized,  they should  contain  standard  contribution  release and protection
language.  The Company has agreed to indemnify Promega in respect of the matter.
See Note 6 to the Company's consolidated financial statements.

Uncertainty Regarding Patents and Proprietary Technology.

     The  Company's  and Genta Jago's  success will  depend,  in part,  on their
respective  abilities  to obtain  patents,  maintain  trade  secrets and operate
without  infringing the proprietary  rights of others. No assurance can be given
that  patents  issued to or  licensed  by the  Company or Genta Jago will not be
challenged,  invalidated or circumvented,  or that the rights granted thereunder
will provide  competitive  advantages to the Company or Genta Jago. There can be
no assurance  that the  Company's or Genta Jago's  patent  applications  will be
approved,  that the Company or Genta Jago will develop additional  products that
are  patentable,  that any issued  patent will provide the Company or Genta Jago
with any competitive advantage or adequate protection for its inventions or will
not be  challenged  by others,  or that the  patents of others  will not have an
adverse  effect on the  ability of the  Company  or Genta  Jago to do  business.
Competitors  may have filed  applications,  may have been issued  patents or may
obtain  additional  patents  and  proprietary  rights  relating  to  products or
processes competitive with those of the Company or Genta


                                       16

<PAGE>



Jago. Furthermore,  there can be no assurance that others will not independently
develop  similar  products,  duplicate  any of the  Company's  or  Genta  Jago's
products or design  around any  patented  products  developed  by the Company or
Genta Jago. The Company and Genta Jago rely on secrecy to protect  technology in
addition  to  patent  protection,  especially  where  patent  protection  is not
believed to be appropriate or obtainable.  No assurance can be given that others
will not independently develop substantially  equivalent proprietary information
and  techniques or otherwise  gain access to the Company's or Genta Jago's trade
secrets, or that the Company or Genta Jago can effectively protect its rights to
its unpatented trade secrets.

     The  Company  and Genta  Jago have  obtained  licenses  or other  rights to
patents and other  proprietary  rights of third parties,  and may be required to
obtain  licenses  to  additional  patents or other  proprietary  rights of third
parties.  No assurance can be given that any existing  licenses and other rights
will remain in effect or that any licenses  required  under any such  additional
patents or proprietary rights would be made available on terms acceptable to the
Company or Genta Jago, if at all. If the Company's or Genta Jago's  licenses and
other rights are  terminated  or if the Company or Genta Jago cannot obtain such
additional licenses, the Company or Genta Jago could encounter delays in product
market  introductions  while it attempts to design  around such patents or could
find  that the  development,  manufacture  or sale of  products  requiring  such
licenses could be foreclosed. In addition, the Company or Genta Jago could incur
substantial  costs,  including  costs caused by delays in  obtaining  regulatory
approval  and  bringing  products to market,  in  defending  itself in any suits
brought  against the Company or Genta Jago claiming  infringement  of the patent
rights of third  parties or in asserting  the  Company's or Genta Jago's  patent
rights,  including  those granted by third  parties,  in a suit against  another
party.  The  Company  or Genta Jago may also  become  involved  in  interference
proceedings  declared by the United States  Patent and Trademark  Office (or any
foreign  counterpart)  in  connection  with one or more of its patents or patent
applications,  which could  result in  substantial  cost to the Company or Genta
Jago,  as well as an adverse  decision as to priority of invention of the patent
or patent  application  involved.  There can be no assurance that the Company or
Genta Jago will have sufficient funds to obtain,  maintain or enforce patents on
their respective products or technology, to obtain or maintain licenses that may
be required in order to develop and commercialize their respective products,  to
contest patents obtained by third parties, or to defend against suits brought by
third parties.

Dependence on Others.

     The Company's and Genta Jago's  strategy for the research,  development and
commercialization  of their  products  requires  negotiating,  entering into and
maintaining  various  arrangements  with  corporate  collaborators,   licensors,
licensees  and others,  and is dependent  upon the  subsequent  success of these
outside parties in performing their responsibilities.  No assurance can be given
that they will obtain such collaborative arrangements on acceptable terms, if at
all, nor can any assurance be given that any current collaborative  arrangements
will be maintained.

Technology Licensed From Third Parties.

     The Company has entered into certain  agreements with, and licensed certain
technology  and  compounds  from,  third  parties.  The  Company  has  relied on
scientific,   technical,  clinical,  commercial  and  other  data  supplied  and
disclosed by others in entering into these agreements,  including the Genta Jago
agreements,  and will rely on such data in  support  of  development  of certain
products.  Although the Company has no reason to believe  that this  information
contains errors of omission or fact, there can be no assurance that there are no
errors of omission or fact that would materially affect the future approvability
or commercial viability of these products.

Potential Adverse Effect of Technological Change and Competition.

     The biotechnology  industry is subject to intense competition and rapid and
significant  technological  change.  The  Company  and Genta Jago have  numerous
competitors  in the  United  States  and other  countries  for their  respective
technologies  and products  under  development,  including  among others,  major
pharmaceutical  and  chemical  companies,   specialized   biotechnology   firms,
universities and other research institutions. There can be no assurance that the
Company's or Genta Jago's competitors will not succeed in developing products or
other novel technologies that are more effective than any which have been or are
being developed by the Company or Genta Jago or which would render the Company's
or Genta Jago's technology and products non-competitive. Many of


                                       17

<PAGE>



the Company's and Genta Jago's competitors have substantially greater financial,
technical,  marketing  and human  resources  than the Company or Genta Jago.  In
addition,  many of those competitors have significantly  greater experience than
the Company or Genta Jago in undertaking pre-clinical testing and human clinical
trials of new  pharmaceutical  products and obtaining  FDA and other  regulatory
approvals of products for use in healthcare. Accordingly, the Company's or Genta
Jago's  competitors  may succeed in obtaining  regulatory  approval for products
more rapidly than the Company or Genta Jago and such  competitors may succeed in
delaying or blocking  regulatory  approvals  of the  Company's  or Genta  Jago's
products.  As competitors  of the Company or of Genta Jago receive  approval for
products that share the same  potential  market as the Company's or Genta Jago's
potential products, the market share available to the Company or Genta Jago will
likely  be  reduced,  thereby  reducing  the  potential  revenues  and  earnings
available  to  the  Company  or  Genta  Jago.  In  addition,  increased  pricing
competition would also likely result, further reducing the earnings potential of
the  Company's  or Genta  Jago's  products.  The  Company is aware that  certain
competitors  of Genta Jago have filed,  and received  approval of, an ANDA for a
generic  formulation of drugs of which Genta Jago was working to develop generic
formulations. Furthermore, if the Company or Genta Jago is permitted to commence
commercial  sales  of  products,  it will  also be  competing  with  respect  to
marketing  capabilities,  an area in which it has limited or no experience,  and
manufacturing  efficiency.  There are many public and private companies that are
conducting  research  and  development  activities  based  on drug  delivery  or
antisense technologies.  The Company believes that the industry-wide interest in
such  technologies  will  accelerate  and  competition  will  intensify  as  the
techniques which permit drug design and development  based on such  technologies
are more widely understood.

Uncertainty of Clinical Trials and Results.

     The  results of  clinical  trials and  pre-clinical  testing are subject to
varying  interpretations.  Even if the  development  of the  Company's  or Genta
Jago's  respective  products  advances to the  clinical  stage,  there can be no
assurance that such products will prove to be safe and  effective.  The products
that are successfully developed, if any, will be subject to requisite regulatory
approval prior to their  commercial sale, and the approval,  if obtainable,  may
take several years. Generally, only a very small percentage of the number of new
pharmaceutical  products  initially  developed  is  approved  for sale.  Even if
products  are approved  for sale,  there can be no  assurance  that they will be
commercially  successful.  The Company or Genta Jago may encounter unanticipated
problems  relating to development,  manufacturing,  distribution  and marketing,
some of which may be beyond the Company's or Genta Jago's  respective  financial
and technical capacity to solve. The failure to address such problems adequately
could have a material adverse effect on the Company's or Genta Jago's respective
businesses,  financial  conditions,  prospects  and  results of  operations.  No
assurance  can be given  that the  Company  or Genta  Jago will  succeed  in the
development  and  marketing of any new drug  products,  or that they will not be
rendered  obsolete  by  products  of  competitors.   "See  "Certain  Trends  and
Uncertainties--Potential    Adverse   Effect   of   Technological   Change   and
Competition."

Difficult Manufacturing Process; Access to Certain Raw Materials.

     The manufacture of Anticode(TM)  oligonucleotides  is a time-consuming  and
complex process. Management believes that the Company has the ability to acquire
or produce  quantities  of  oligonucleotides  sufficient  to support its present
needs for research and its projected needs for its initial clinical  development
programs.  However, in order to obtain  oligonucleotides  sufficient to meet the
volume and cost  requirements  needed for  certain  commercial  applications  of
Anticode(TM)  oligonucleotide  products,  the  Company  requires  raw  materials
currently  provided by a single  supplier  which is itself a  development  stage
biotechnology  company  (and a  competitor  of the  Company)  and is  subject to
uncertainties  including  the  potential  for a  decision  by such  supplier  to
discontinue  production of such raw materials,  the insolvency of such supplier,
or the failure of such  supplier  to follow  applicable  regulatory  guidelines.
Products  based  on  chemically  modified   oligonucleotides   have  never  been
manufactured on a commercial  scale. The manufacture of all of the Company's and
Genta Jago's products will be subject to current GMP requirements  prescribed by
the FDA or other standards  prescribed by the appropriate  regulatory  agency in
the  country of use.  There can be no  assurance  that the Company or Genta Jago
will be able to manufacture products, or have products manufactured for it, in a
timely  fashion at  acceptable  quality  and  prices,  that they or third  party
manufacturers can comply with GMP or that they or third party manufacturers will
be able to manufacture an


                                       18

<PAGE>



adequate  supply of product.  Failure to  establish  compliance  with GMP to the
satisfaction of the FDA can result in delays in, or prohibition from, initiating
clinical trials or commercial marketing of a product.

Limited Sales, Marketing and Distribution Experience.

     The Company and Genta Jago have very limited  experience in  pharmaceutical
sales, marketing and distribution.  In order to market and sell certain products
directly, the Company or Genta Jago would have to develop or subcontract a sales
force and a marketing group with technical expertise.  There can be no assurance
that any direct sales or marketing efforts would be successful.

Uncertainty of Product Pricing, Reimbursement and Related Matters.

     The  Company's  and  Genta  Jago's  business  may be  materially  adversely
affected by the  continuing  efforts of  governmental  and third party payers to
contain or reduce the costs of healthcare through various means. For example, in
certain foreign markets the pricing or profitability  of healthcare  products is
subject to government  control.  In the United States,  there have been, and the
Company  expects  that there will  continue to be, a number of federal and state
proposals to implement similar  governmental  control.  While the Company cannot
predict whether any such legislative or regulatory  proposals or reforms will be
adopted,  the adoption of any such proposal or reform could adversely affect the
commercial  viability of the Company's and Genta Jago's potential  products.  In
addition, in both the United States and elsewhere,  sales of healthcare products
are dependent in part on the  availability of reimbursement to the consumer from
third party payers,  such as government and private insurance plans. Third party
payers are increasingly  challenging the prices charged for medical products and
services,  and therefore significant  uncertainty exists as to the reimbursement
of existing and newly-approved healthcare products. If the Company or Genta Jago
succeeds in bringing one or more  products to market,  there can be no assurance
that these products will be considered cost effective and that  reimbursement to
the consumer  will be available  or will be  sufficient  to allow the Company or
Genta Jago to sell its products on a competitive basis. Finally, given the above
potential  market  constraints  on  pricing,  the  availability  of  competitive
products in these  markets  may further  limit the  Company's  and Genta  Jago's
flexibility in pricing and in obtaining adequate reimbursement for its potential
products.  See "Certain  Trends and  Uncertainties--Potential  Adverse Effect of
Technological Change and Competition."

Need for and Dependence on Qualified Personnel.

     The  Company's  success is highly  dependent on the hiring and retention of
key personnel and scientific  staff. The loss of key personnel or the failure to
recruit necessary  additional  personnel or both is likely further to impede the
achievement  of  development  objectives.   There  is  intense  competition  for
qualified personnel in the areas of the Company's  activities,  and there can be
no assurance  that the Company will be able to attract and retain the  qualified
personnel necessary for the development of its business.

Product Liability Exposure; Limited Insurance Coverage.

     The Company's,  JBL's and Genta Jago's  businesses expose them to potential
product  liability  risks  that  are  inherent  in the  testing,  manufacturing,
marketing and sale of human therapeutic products.  The Company has also obtained
a level  of  liability  insurance  coverage  that it deems  appropriate  for its
current  stage of  development.  However,  there  can be no  assurance  that the
Company's present insurance coverage is adequate. Such existing coverage may not
be adequate as the Company further  develops  products,  and no assurance can be
given that,  in the future,  adequate  insurance  coverage  will be available in
sufficient  amounts or at a reasonable  cost, or that a product  liability claim
would not have a material adverse effect on the business or financial  condition
of the Company.

Hazardous Materials; Environmental Matters.

     The Company's research and development and manufacturing  processes involve
the  controlled  storage,  use and disposal of hazardous  materials,  biological
hazardous materials and radioactive compounds. The Company is


                                       19

<PAGE>



subject to  federal,  state and local laws and  regulations  governing  the use,
manufacture,  storage, handling and disposal of such materials and certain waste
products.  Although the Company believes that its safety procedures for handling
and disposing of such  materials  comply with the  standards  prescribed by such
laws and regulations,  the risk of accidental contamination or injury from these
materials cannot be completely eliminated. In the event of such an accident, the
Company may be held liable for any damages that result,  and any such  liability
could exceed the  resources of the Company.  There can be no assurance  that the
Company  will  not be  required  to  incur  significant  costs  to  comply  with
environmental  laws and  regulations  in the  future,  nor that the  operations,
business or assets of the Company will not be materially  adversely  affected by
current or future  environmental  laws or  regulations.  See "Certain Trends and
Uncertainties--No Assurance of Regulatory Approval; Government Regulation" for a
discussion of the Spill.

Volatility of Stock Price; Market Overhang from Outstanding Convertible
Securities and Warrants.

     The market price of the  Company's  Common  Stock,  like that of the common
stock of many other  biopharmaceutical  companies,  has been highly volatile and
may be so in the future.  Factors  such as, among other  things,  the results of
pre-clinical  studies and clinical  trials by the  Company,  Genta Jago or their
competitors,  other  evidence  of the  safety or  efficacy  of  products  of the
Company,  Genta  Jago  or  their  competitors,  announcements  of  technological
innovations  or new  therapeutic  products by the  Company,  Genta Jago or their
competitors,   governmental   regulation,   developments   in  patent  or  other
proprietary rights of the Company,  Genta Jago or their respective  competitors,
including  litigation,  fluctuations  in the Company's  operating  results,  and
market  conditions  for  biopharmaceutical   stocks  in  general  could  have  a
significant  impact on the future price of the Common Stock.  As of May 3, 1999,
the Company had 15,401,275 shares of Common Stock  outstanding.  Future sales of
shares of Common Stock by existing stockholders,  holders of preferred stock who
might convert such  preferred  stock into Common  Stock,  and option and warrant
holders also could adversely affect the market price of the Common Stock.

     No  predictions  can be made of the effect that future  market sales of the
shares of Common  Stock  underlying  the  convertible  securities  and  warrants
referred to under the caption  "Certain Trends and  Uncertainties--Subordination
of Common Stock to Series A Preferred Stock and Series D Preferred  Stock;  Risk
of Dilution;  Anti-dilution Adjustments," or the availability of such securities
for sale, will have on the market price of the Common Stock prevailing from time
to time.  Sales of substantial  amounts of Common Stock,  or the perception that
such sales might occur, could adversely affect prevailing market prices.

Certain Interlocking Relationships; Potential Conflicts of Interest.

     The Aries  Funds have the  contractual  right to appoint a majority  of the
members  of the  Board  of  Directors  of the  Company.  The  Aries  Funds  have
designated Michael S. Weiss, Glenn L. Cooper, M.D., Donald G. Drapkin,  Bobby W.
Sandage,  Jr., Ph.D., and Andrew J. Stein as nominees to the Board of Directors.
Such persons were elected as Directors of the Company.  Paramount  Capital Asset
Management,  Inc. ("PCAM") is the investment  manager and general partner of The
Aries Trust and the Aries Domestic  Fund,  L.P.,  respectively.  The Aries Funds
have  the  present  right  to  convert  and  exercise  their  securities  into a
significant  portion of the  outstanding  Common Stock.  See "Certain Trends and
Uncertainties--Concentration  of Ownership and Control"  below.  Dr.  Lindsay A.
Rosenwald,  the President and sole stockholder of PCAM, is also the President of
Paramount Capital,  Inc. and of Paramount Capital Investments LLC ("PCI"), a New
York-based   merchant   banking  and  venture   capital  firm   specializing  in
biotechnology  companies. In the regular course of its business, PCI identifies,
evaluates and pursues investment  opportunities in biomedical and pharmaceutical
products, technologies and companies. Generally, Delaware corporate law requires
that any transactions  between the Company and any of its affiliates be on terms
that, when taken as a whole,  are  substantially  as favorable to the Company as
those then  reasonably  obtainable  from a person who is not an  affiliate in an
arms-length  transaction.  Nevertheless,  neither  such  affiliates  nor  PCI is
obligated  pursuant to any agreement or  understanding  with the Company to make
any additional products or technologies  available to the Company, nor can there
be any  assurance,  and the Company does not expect and investors in the Company
should not expect,  that any biomedical or pharmaceutical  product or technology
identified by such affiliates or PCI in the future will be made available to the
Company.  In  addition,  certain of the current  officers  and  directors of the
Company  or  certain of any  officers  or  directors  of the  Company  hereafter
appointed may from time to time serve as officers or directors of other


                                       20

<PAGE>



biopharmaceutical  or  biotechnology  companies.  There can be no assurance that
such other  companies  will not have  interests  in  conflict  with those of the
Company.

Concentration of Ownership and Control.

     The Company's directors,  executive officers and principal stockholders and
certain of their  affiliates  have the ability to influence  the election of the
Company's directors and most other stockholder  actions. See "Certain Trends and
Uncertainties--Certain   Interlocking  Relationships;   Potential  Conflicts  of
Interest."  Accordingly,  the Aries Funds have the ability to exert  significant
influence  over the  election  of the  Company's  Board of  Directors  and other
matters submitted to the Company's stockholders for approval. These arrangements
may  discourage  or prevent  any  proposed  takeover of the  Company,  including
transactions in which  stockholders  might otherwise receive a premium for their
shares over the then current  market  prices.  Such  stockholders  may influence
corporate actions,  including influencing elections of directors and significant
corporate events. See also "Certain Trends and  Uncertainties--Effect of Certain
Anti-Takeover Provisions" below.

Effect of Certain Anti-Takeover Provisions.

     The Company's  Restated  Certificate of  Incorporation  and By-laws include
provisions that could discourage  potential  takeover attempts and make attempts
by stockholders to change management more difficult.  The approval of 66-2/3% of
the Company's  voting stock is required to approve certain  transactions  and to
take certain stockholder actions, including the amendment of the By-laws and the
amendment,  if any, of the anti-takeover  provisions  contained in the Company's
Restated Certificate of Incorporation.

Risks of Low-Priced Stock; Possible Effect of "Penny Stock" Rules on Liquidity
for the Company's Securities.

     If the  Company's  securities  were not  listed  on a  national  securities
exchange nor listed on a qualified  automated  quotation system, they may become
subject to Rule 15g-9 under the Exchange  Act,  which imposes  additional  sales
practice  requirements  on  broker-dealers  that sell such securities to persons
other  than  established  customers  and  "accredited   investors"   (generally,
individuals with a net worth in excess of $1,000,000 or annual incomes exceeding
$200,000 or $300,000  together with their  spouses).  Rule 15g-9 defines  "penny
stock" to be any equity security that has a market price (as therein defined) of
less than  $5.00 per share or an  exercise  price of less than  $5.00 per share,
subject to certain  exceptions  including (i) the securities being quoted on the
Nasdaq National Market or SmallCap Market and (ii) the securities' issuer having
net  tangible  assets in excess of  $2,000,000  and  having  been in  continuous
operation  for at least  three  years  (both  exceptions  enumerated  above  are
currently  met by the  Company).  For  transactions  covered  by Rule  15g-9,  a
broker-dealer  must make a special  suitability  determination for the purchaser
and have received the purchaser's  written  consent to the transaction  prior to
sale. For any  transaction  involving a penny stock,  unless  exempt,  the rules
require  delivery,  prior to any  transaction in a penny stock,  of a disclosure
schedule  prepared by the SEC relating to the penny stock market.  Disclosure is
also  required  to  be  made  about  sales  commissions   payable  to  both  the
broker-dealer and the registered  representative  and current quotations for the
securities.  Finally,  monthly  statements  are  required to be sent  disclosing
recent price information for the penny stock held in the account and information
on the limited  market in penny  stock.  Consequently,  such Rule may affect the
ability of  broker-dealers  to sell the Company's  securities and may affect the
ability of purchasers  to sell any of the Company's  securities in the secondary
market.

     There can be no assurance  that the Company's  securities  will continue to
qualify for exemption from the penny stock  restrictions.  In any event, even if
the Company's  securities are exempt from such  restrictions,  the Company would
remain subject to Section  15(b)(6) of the Exchange Act, which gives the SEC the
authority to restrict any person from  participating  in a distribution of penny
stock, if the SEC finds that such a restriction would be in the public interest.

     If the Company's  securities were subject to the rules on penny stocks, the
market  liquidity for the  Company's  securities  could be materially  adversely
affected.



                                       21

<PAGE>



PART II. OTHER INFORMATION

Item 1.  Legal Proceedings

     On June 4, 1998, the Company's  statutory  process agent received a Summons
and  Complaint  in a lawsuit  brought by Johns  Hopkins  against  the Company in
Maryland  Circuit Court for Baltimore  City (Case No.  98120110).  Johns Hopkins
alleges  in the  Complaint  that the  Company  has  breached  the Johns  Hopkins
Agreement and owes it licensing  royalty fees and related expenses in the amount
of $308,832.  Johns Hopkins also alleges the existence of a separate  March 1993
letter agreement  wherein the Company agreed to support a fellowship  program at
the Johns Hopkins  School of Hygiene and Public Health and the Company's  breach
thereof,  with damages of $326,829.  On August 10, 1998, the Company's statutory
process agent received a Summons and Complaint in a related  lawsuit  brought by
the  Ts'o/Miller  Partnership  and others  against the Company in the same court
(Case  No.  98182113).  The  Ts'o/Miller  Partnership  claims  that  it is  owed
licensing  royalty fees in the amount of  $287,671.  The Company is currently in
settlement negotiations.  The Company believes that no further accrual should be
necessary in connection with this settlement.

     In October 1996, JBL retained a chemical  consulting firm to advise it with
respect to an  incident of soil and  groundwater  contamination  (the  "Spill").
Sampling  conducted at the JBL facility  revealed the presence of chloroform and
perchloroethylenes  ("PCEs")  in the  soil  and  groundwater  at  this  site.  A
quarterly  groundwater   monitoring  program  is  being  conducted,   under  the
supervision of the California Regional Water Quality Control Board, for purposes
of  determining  whether the levels of chloroform  and PCEs have  decreased over
time. The results of the latest sampling conducted show that PCEs and chloroform
have decreased in all but one of the monitoring sites. The Company has agreed to
indemnify Promega in respect of this matter. The Company believes that any costs
stemming from further  investigating or remediating this  contamination will not
have a material  adverse  effect on the business of the Company,  although there
can be no assurance thereof.

     JBL received notice on October 16, 1998 from Region IX of the Environmental
Protection  Agency  ("EPA")  that  it  had  been  identified  as  a  potentially
responsible  party ("PRP") at the Casmalia  Disposal  Site,  which is located in
Santa Barbara,  California.  JBL has been  designated as a de minimis PRP by the
EPA. The EPA  currently  estimates  that the de minimis PRPs will be required to
pay as little as  $75,000  and as much as  $750,000  to settle  their  potential
liability,  depending upon the volume of wastes  attributed to them. The Company
received an estimated volume calculation from the EPA, and a response,  which is
due on June  9,  1999,  is  currently  under  review.  While  the  terms  of the
settlement  with the EPA have not been finalized,  they should contain  standard
contribution  protection and release  language.  The Company has accrued $75,000
during  1998.  The  Company  believes  that  any  costs  stemming  from  further
investigating or remediating this contamination will not have a material adverse
effect on the  business  of the  Company,  although  there  can be no  assurance
thereof. The Company has agreed to indemnify Promega in respect of this matter.



                                       22
<PAGE>

Item 6.  Exhibits and Reports on Form 8-K

          (a)  Exhibits.

Exhibit
Number    Description of Document
- ------    -----------------------

10.1      Sublease,   dated  as  of  March   31,   1999,   between   Interneuron
          Pharmaceuticals, Inc. and the Company

10.2      Asset  Purchase  Agreement,  dated as of March  19,  1999,  among  JBL
          Acquisition Corp., Promega Corporation,  JBL Scientific,  Inc. and the
          Company

27        Financial Data Schedule

          (b)  Reports on Form 8-K.

(i)  A Current  Report on Form 8-K was filed by the  Company  on January 6, 1999
     regarding a settlement with LBC Capital Resources, Inc.

(ii) A Current  Report on Form 8-K was filed on February 10, 1999  regarding the
     engagement of Deloitte & Touche LLP as the Company's principal  independent
     accountant.




                                       23

<PAGE>



                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.




                               GENTA INCORPORATED
                              (Registrant)





                               By:      /s/ Kenneth G. Kasses, Ph.D.
                                        ---------------------------------
                               Name:    Kenneth G. Kasses, Ph.D.
                               Title:   Chairman of the Board of Directors,
                                        President, Principal Executive Officer










                               By:      /s/ Gerald M. Schimmoeller
                                        ---------------------------------
                               Name:    Gerald M. Schimmoeller
                               Title:   Vice President,  Chief Financial Officer
                                        and Principal Accounting Officer

Date:    May 15, 1999


                                       24



                                                                    Exhibit 10.1

                              AGREEMENT OF SUBLEASE

                                     between

                 INTERNEURON PHARMACEUTICALS, INC., Sublandlord

                                       and

                             GENTA, INC., Subtenant

                              Dated: March 31, 1999

PREMISES:

Portions of 200 Level
Ledgemont Development Center
128 Spring Street
Lexington, Massachusetts

<PAGE>

                                SUBLEASE BETWEEN
                 INTERNEURON PHARMACEUTICALS, INC., SUBLANDLORD
                                       AND
                             GENTA, INC., SUBTENANT

         SUBLEASE  made  as of  the  31st  day of  March,  1999  by and  between
INTERNEURON PHARMACEUTICALS,  INC., a Delaware corporation,  having an office at
99  Hayden  Avenue,   Lexington,   Massachusetts   02173   (hereinafter   called
"Sublandlord"),  and GENTA, INC., a Delaware corporation, having an office at 99
Hayden Avenue, Lexington, Massachusetts 02173 (hereinafter called "Subtenant").

                               W I T N E S S E T H

         WHEREAS:

         A. By lease dated  February 5, 1997,  as amended by that  certain  Side
Agreement  regarding  indoor air quality dated January 31, 1997 and that certain
First Amendment to Lease dated February 12, 1997 (the "First  Amendment") (which
lease, as the same has been and may hereafter be further amended, is hereinafter
referred to as the "Overlease"), Ledgemont Realty Trust u/d/t dated December 12,
1984 (hereinafter  called  "Overlandlord")  leased to Sublandlord  certain space
(hereinafter  called the  "Leased  Space") in the  building  known as  Ledgemont
Development  Center  located  at 128  Spring  Street,  Lexington,  Massachusetts


<PAGE>

(hereinafter  called  the  "Building")  in  accordance  with  the  terms  of the
Overlease. A copy of the Overlease is annexed hereto as Exhibit A.

         B.  Sublandlord  and  Subtenant  desire to consummate a subleasing of a
portion of the Leased Space on terms and conditions  contained in this agreement
(hereinafter called the "Sublease").


         NOW, THEREFORE, in consideration of the mutual covenants and agreements
hereinafter contained, it is hereby agreed as follows:

         l.

         1.1.  Sublandlord hereby leases to Subtenant and Subtenant hereby hires
from  Sublandlord  the portion of the 200 level of the East Wing of the Building
(comprising  a portion of the Leased  Space) shown  hatched on Exhibit B annexed
hereto and made a part hereof (hereinafter referred to as the "Premises"), for a
term (the  "Sublease  Term") to commence on the date that  Sublandlord  delivers
possession  of the  Premises  to  Subtenant  (hereinafter  called the  "Sublease
Commencement  Date"),  and to end on March  31,  2001  (hereinafter  called  the
"Sublease Expiration Date"), or until such term shall sooner cease and terminate
as herein provided.

         1.2. The annual fixed rent (hereinafter called "Fixed Rent") payable by
Subtenant hereunder during the Sublease Term shall be paid to Sublandlord at the
rate of  FORTY-THREE  THOUSAND FOUR HUNDRED  FIFTY FOUR AND 26/100  ($43,454.26)
DOLLARS per annum during the period commencing on the Sublease Commencement Date
and  ending on the  Sublease  Expiration  Date.  The Fixed Rent is to be paid by
Subtenant to  Sublandlord  at  Sublandlord's  office (or such other  location as
Sublandlord  shall  designate) by



                                       2
<PAGE>

check drawn on a Massachusetts bank in equal monthly installments in advance, on
the first day of each month  during  the  Sublease  Term  without  any  set-off,
off-set,  abatement or reduction  whatsoever.  The security deposit payable with
respect to Article 19 hereof shall be paid upon the  execution of this  Sublease
by Subtenant.

         1.3.  Simultaneous  with the execution of this  Sublease,  Subtenant is
paying to Sublandlord the sum of $6,174.77 which shall be applied by Sublandlord
to the first (1st) monthly installment of Fixed Rent due hereunder.

         1.4.  Sublandlord  and Subtenant agree to the following with respect to
Subtenant's use of services within and access to the Premises:

         (a)  Subtenant  may use:  (i) the  kitchen/lounge,  (ii)  the  exercise
facilities,  provided  and on  condition  that  each  of  Subtenant's  employees
utilizing such exercise facilities  furnishes  Sublandlord with a written waiver
of  liability,  satisfactory  to  Sublandlord,  and  (iii)  either  of the front
training  rooms (A or B),  provided  that  Subtenant's  employees  shall  not be
entitled to use both front training rooms at the same time and provided  further
that  any such  use  shall be  subject  to  unavailability,  including,  without
limitation,  unavailability  resulting  from  Sublandlord's  employees  priority
status with respect to access to and use of the same.

         (b) Subtenant may utilize the administrative services of Richard Hector
or any employee hereafter  substituted by Sublandlord for Richard Hector, to the
extent available and provided that all use of such administrative services shall
first be approved by  Sublandlord's  office  manager.  Subtenant shall be billed
from time to time for all such administrative services in excess of one hour per
month at the hourly rate of $40.00, which Subtenant shall pay as additional rent
within ten (10) days after being billed therefor.



                                       3
<PAGE>

         2.

         2.1. Subtenant shall not (a) assign this Sublease,  nor (b) permit this
Sublease to be assigned by operation of law or  otherwise,  nor (c) underlet all
or any part of the  Premises,  nor (d)  permit  the  Premises  or any desk space
therein to be occupied by any person(s) other than Subtenant,  nor (e) pledge or
encumber  this  Sublease,  the term and estate  hereby  granted  or the  rentals
hereunder.

         3.

         3.1. Except as herein otherwise  expressly  provided and except for the
obligation  to pay rent and  additional  rent  under the  Overlease,  all of the
terms,  covenants,  conditions  and  provisions  in  the  Overlease  are  hereby
incorporated  in,  and  made a part  of  this  Sublease,  and  such  rights  and
obligations  as are  contained  in the  Overlease  are hereby  imposed  upon the
respective  parties  hereto;  the Sublandlord  herein being  substituted for the
Landlord in the Overlease,  and the Subtenant  herein being  substituted for the
Tenant named in the Overlease;  provided,  however,  that the Sublandlord herein
shall not be liable for any defaults by Overlandlord.  If the Overlease shall be
terminated  for any reason  during the term hereof,  then and in that event this
Sublease shall thereupon  automatically  terminate and Sublandlord shall have no
liability to Subtenant by reason thereof. Upon the termination of this Sublease,
whether by forfeiture,  lapse of time or otherwise,  or upon the  termination of
Subtenant's right to possession, Subtenant will at once surrender and deliver up
the Premises in good  condition and repair,  reasonable  wear and tear excepted.
Notwithstanding  any  language  to the  contrary  contained  in  this  Sublease,
Subtenant  agrees  that  Sublandlord  may at any  time  after  the  date  hereof
surrender  the Overlease and the premises  demised  thereunder to  Overlandlord,
provided



                                       4
<PAGE>

Overlandlord  shall  deliver a written  agreement  to Subtenant  providing  that
notwithstanding  such  surrender  Overlandlord  shall  not  disturb  Subtenant's
occupancy of the  Premises so long as  Subtenant is not in default  hereunder if
Subtenant shall at Overlandlord's  election either (i) attorn to Overlandlord as
if Overlandlord  were the sublandlord  hereunder or (ii) enter into a lease with
Overlandlord  for the  remaining  term of the  Sublease  on the same  terms  and
conditions contained herein.

         3.2. For  purposes of this  Sublease,  the second  paragraph of Section
2.1, Sections 2.3, 2.5, 2.6, 2.7, 2.8, 3.1, 4.1.1, 4.1.2, the second sentence of
Section 5.1.9,  Sections 5.1.11,  5.2.3,  8.1, 9.1,  Appendix A, Appendix E, and
Paragraphs 1 and 2 of the First  Amendment,  and all references in the Overlease
to the aforesaid  Articles,  Sections or  Appendices  of the  Overlease  between
Overlandlord and Sublandlord shall not be incorporated in or made a part hereof.
In addition,  for the purposes of this  Sublease,  Article 1 of the Overlease is
incorporated only to the extent the definitions contained therein are consistent
with the terms hereof (i.e., references to Premises,  Landlord,  Tenant, Initial
Term,  Commencement  Date, Rent  Commencement  Date,  Ending Date,  Annual Fixed
Rent-Initial  Term,  Extension Term,  Annual Fixed  Rent-Extension  Term, Tenant
Improvement  Allowance,  Parking Spaces,  Tenant's  Operating  Percentage Share,
Tenant's Tax Percentage  Share and Broker are not applicable to this  Sublease),
and Sections 4.3.1,  4.3.2,  4.4.1,  and 4.4.2 of the Overlease are incorporated
herein only for the purposes of Article 11 of this Sublease.

         4.

         4.1.  Subtenant  has  examined the  Premises,  is aware of the physical
condition  thereof,  and agrees to take the same "as is," with the understanding
that there  shall be no



                                       5
<PAGE>

obligation on the part of Sublandlord to perform any work,  supply any materials
or incur any  expense  whatsoever  in  connection  with the  preparation  of the
Premises for Subtenant's occupancy thereof.

         4.2.  Subtenant  shall  pay to  Sublandlord  upon  demand  therefor  as
additional  rent all  costs  incurred  by  Sublandlord  in making  the  Premises
available  to the  Subtenant,  including,  but  not  limited  to  costs  to move
Sublandlord's furniture,  fixtures, computer and communications connections from
the Premises and relocate and reinstall the same elsewhere.  Upon termination of
the Sublease,  Subtenant shall pay to Sublandlord upon demand therefor all costs
incurred by  Sublandlord  to restore the  Premises to the  condition as the same
were prior to Subtenant's  occupation  thereof pursuant to this Sublease and all
costs  incurred by Sublandlord  to move its  furniture,  fixtures,  computer and
communications connections back to and reinstall the same in the Premises to the
extent they existed prior to this Sublease.

         5.

         5.1.  Subtenant  agrees that the  Premises  shall be  occupied  only as
executive, administrative and general offices for Subtenant's business. 6.

         6.1. This Sublease is conditioned  upon the consent by  Overlandlord to
this  Sublease  which  consent  shall be evidenced by  Overlandlord's  signature
appended hereto or a separate  consent in the form utilized by Overlandlord  for
such purposes.

         6.2.  Subtenant  stipulates  that it is familiar with the provisions of
Section 5.1.11 of the Overlease.  In the event that Overlandlord  shall exercise
any of its options  pursuant to Section  5.1.11 of the Overlease with respect to
the  Premises  upon  Sublandlord's  request for



                                       6
<PAGE>

Overlandlord's  consent to this Sublease,  Sublandlord  will so notify Subtenant
and, upon receipt of such  notification by  Sublandlord,  this Sublease shall be
deemed to be null and void and  without  force or effect,  and  Sublandlord  and
Subtenant  shall have no further  obligations  or  liabilities to the other with
respect to this Sublease.

         6.3. In the event  Overlandlord  shall not  exercise any of its options
pursuant  to Section  5.1.11 of the  Overlease  with  respect  to the  Premises,
Sublandlord  makes no  representation  with respect to obtaining  Overlandlord's
approval  of  this  Sublease  and,  in  the  event  that  Overlandlord  notifies
Sublandlord that Overlandlord  will not give such approval,  Sublandlord will so
notify  Subtenant and, upon receipt of such  notification  by Sublandlord of the
disapproval by  Overlandlord,  this Sublease shall be deemed to be null and void
and without force or effect, and Sublandlord and Subtenant shall have no further
obligations or liabilities to the other with respect to this Sublease.

         6.4. Except as otherwise specifically provided herein, wherever in this
Sublease  Subtenant  is required to obtain  Sublandlord's  consent or  approval,
Subtenant  understands  that  Sublandlord  may be required  to first  obtain the
consent or approval of Overlandlord.  If Overlandlord should refuse such consent
or  approval,  Sublandlord  shall be  released  of any  obligation  to grant its
consent  or  approval  whether or not  Overlandlord's  refusal,  in  Subtenant's
opinion,  is arbitrary or unreasonable.  Subtenant agrees that Sublandlord shall
not be required to dispute any  determinations  or other assertions or claims of
Overlandlord  regarding the  obligations of Sublandlord  under the Overlease for
which Subtenant is or may be responsible under the terms of this Sublease.

         7.



                                       7
<PAGE>

         7.1. Subtenant acknowledges that all services,  repairs,  restorations,
equipment and access to and for the Premises and any  insurance  coverage of the
Building will in fact be provided by Overlandlord, and Sublandlord shall have no
obligation  during  the term of this  Sublease  to  provide  any such  services,
repairs, restorations,  equipment, access or insurance. Subtenant agrees to look
solely  to   Overlandlord   for  the  furnishing  of  such  services,   repairs,
restorations,  equipment, access and insurance. Sublandlord shall in no event be
liable to Subtenant nor shall the obligations of Subtenant hereunder be impaired
or  the  performance  thereof  excused  because  of  any  failure  or  delay  on
Overlandlord's  part  in  furnishing  such  services,   repairs,   restorations,
equipment,  access or  insurance.  If  Overlandlord  shall default in any of its
obligations  to  Sublandlord  with respect to the Premises,  Subtenant  shall be
entitled to participate  with  Sublandlord in the  enforcement of  Sublandlord's
rights against  Overlandlord,  but Sublandlord shall have no obligation to bring
any action or  proceeding or to take any steps to enforce  Sublandlord's  rights
against  Overlandlord.  If, after written  request from  Subtenant,  Sublandlord
shall  fail or  refuse  to  take  appropriate  action  for  the  enforcement  of
Sublandlord's  rights against Overlandlord with respect to the Premises within a
reasonable  period of time  considering  the nature of  Overlandlord's  default,
Subtenant shall have the right to take such action in its own name, and for that
purpose  and only to such  extent,  all of the rights of  Sublandlord  under the
Overlease  hereby are  conferred  upon and assigned to Subtenant  and  Subtenant
hereby is  subrogated  to such rights to the extent that the same shall apply to
the Premises.  If any such action against Overlandlord in Subtenant's name shall
be barred by reason of lack of privity, nonassignability or otherwise, Subtenant
may take such action in Sublandlord's



                                       8
<PAGE>

name provided  Subtenant has obtained the prior written  consent of Sublandlord,
which  consent  shall not be  unreasonably  withheld or delayed,  provided,  and
Subtenant  hereby agrees,  that Subtenant shall  indemnify and hold  Sublandlord
harmless from and against all  liability,  loss,  damage or expense,  including,
without limitation,  reasonable  attorney's fees, which Sublandlord shall suffer
or incur by reason of such action.

         7.2.  Anything  contained  in any  provisions  of this  Sublease to the
contrary  notwithstanding,  Subtenant agrees,  with respect to the Premises,  to
comply  with and  remedy  any  default  claimed  by  Overlandlord  and caused by
Subtenant,  within  the  period  allowed  to  Sublandlord  as  tenant  under the
Overlease, even if such time period is shorter than the period otherwise allowed
in the  Overlease,  due to the fact that notice of default from  Sublandlord  to
Subtenant is given after the corresponding  notice of default from Overlandlord.
Sublandlord agrees to forward to Subtenant, upon receipt thereof by Sublandlord,
a copy of each notice of default  received  by  Sublandlord  in its  capacity as
tenant under the Overlease.  Subtenant  agrees to forward to  Sublandlord,  upon
receipt thereof, copies of any notices received by Subtenant with respect to the
Premises from Overlandlord or from any governmental authorities.

         8.

         8.1.  Sublandlord  represents (a) that it is the holder of the interest
of the tenant under the  Overlease  and (b) that the  Overlease is in full force
and effect.

         9.

         9.1. This  Sublease is subject to, and Subtenant  accepts this Sublease
subject to, any  amendments  and  supplements  to the Overlease  hereafter  made
between  Overlandlord  and  Sublandlord,  provided  that any such  amendment  or
supplement  to the  Overlease  will not prevent



                                       9
<PAGE>

or adversely  affect the use by Subtenant of the Premises in accordance with the
terms of this  Sublease,  increase the  obligations of Subtenant or decrease its
rights  under  the  Sublease  or in any other way  materially  adversely  affect
Subtenant.

         9.2. This Sublease is subject and  subordinate  to the Overlease and to
all ground or underlying  leases and to all mortgages which may now or hereafter
affect such leases or the real property of which the Premises are a part and all
renewals,  modifications,  replacements  and extensions of any of the foregoing.
This  Section  9.2  shall  be  self-operative   and  no  further  instrument  of
subordination shall be required. To confirm such subordination,  Subtenant shall
execute promptly any certificate that Sublandlord may request.

         10.

         10.1. Subtenant  covenants,  represents and warrants that Subtenant has
had no dealings or  communications  with any broker or agent in connection  with
the  consummation of this Sublease,  and Subtenant  covenants and agrees to pay,
hold  harmless  and  indemnify  Sublandlord  from and  against any and all cost,
expense   (including   reasonable   attorneys'   fees)  or  liability   for  any
compensation, commissions or charges claimed by any broker or agent with respect
to this Sublease or the negotiation thereof.

         11.

         11.1.  Subtenant  stipulates that it is familiar with the provisions of
Sections  4.3.1.  and 4.3.2.  of the  Overlease.  In the event of any payment of
additional rent by Sublandlord to Overlandlord  during the term of this Sublease
which is  attributable  to the provisions of Sections  4.3.1.  and 4.3.2. of the
Overlease  (such  additional  rent payable by  Sublandlord  pursuant to Sections
4.3.1. and 4.3.2. of the Overlease being hereinafter called "Section 4.3 Rent"),
then



                                       10
<PAGE>

Subtenant shall pay as additional rent pursuant to this Sublease an amount equal
to 1.248% of the Section 4.3 Rent.  For  purposes of this  Section  11.1 of this
Sublease,  the Premises shall be deemed to contain  approximately 2,276 rentable
square feet and the Leased Space shall be deemed to contain 182,317 square feet.
At such time as the  Section  4.3 Rent  payable by  Sublandlord  is  adjusted by
reason of any change in the rentable  area of the Leased Space,  the  percentage
thereof payable by Subtenant to Sublandlord shall be similarly adjusted.  At any
time after  payment by  Sublandlord  to  Overlandlord  of any  Section 4.3 Rent,
Sublandlord  may deliver to Subtenant a statement with respect to the payment of
the Section 4.3 Rent and, within ten (10) days after delivery of such statement,
Subtenant  shall pay to Sublandlord  additional  rent determined as aforesaid in
this Section 11.1.  Additional rent payable  pursuant to this Section 11.1 shall
be based  solely  upon  actual  payments  made by  Sublandlord  pursuant  to the
provisions of Sections 4.3.1.  and 4.3.2. of the Overlease.  Subtenant shall not
have the right to question  the  propriety  of or the basis for any such payment
and  Sublandlord  shall be under no  obligation  to  contest  any such  payment.
Sublandlord  shall,  however,  at the written  request of Subtenant,  furnish to
Subtenant evidence of such payment.

         11.2.  Subtenant  stipulates that it is familiar with the provisions of
Sections  4.4.1.  and 4.4.2.  of the  Overlease.  In the event of any payment of
additional rent by Sublandlord to Overlandlord  during the term of this Sublease
which is  attributable  to the provisions of Sections  4.4.1.  and 4.4.2. of the
Overlease  (such  additional  rent payable by  Sublandlord  pursuant to Sections
4.4.1. and 4.4.2. of the Overlease being hereinafter called "Section 4.4 Rent"),
then Subtenant  shall pay as additional rent pursuant to this Sublease an amount
equal to 4.473% of the Section 4.4 Rent.  For  purposes of this  Section 11.2 of
this  Sublease,  the  Premises  shall be



                                       11
<PAGE>

deemed to contain  approximately 2,276 rentable square feet and the Leased Space
shall be deemed to contain  50,883  square feet. At such time as the Section 4.4
Rent payable by  Sublandlord is adjusted by reason of any change in the rentable
area of the  Leased  Space,  the  percentage  thereof  payable by  Subtenant  to
Sublandlord  shall  be  similarly  adjusted.   At  any  time  after  payment  by
Sublandlord to Overlandlord of any Section 4.4 Rent,  Sublandlord may deliver to
Subtenant a statement  with  respect to the payment of the Section 4.4 Rent and,
within ten (10) days after delivery of such  statement,  Subtenant  shall pay to
Sublandlord  additional  rent  determined  as aforesaid  in this  Section  11.2.
Additional rent payable pursuant to this Section 11.2 shall be based solely upon
actual  payments  made by  Sublandlord  pursuant to the  provisions  of Sections
4.4.1.  and  4.4.2.  of the  Overlease.  Subtenant  shall  not have the right to
question  the  propriety  of or the basis for any such  payment and  Sublandlord
shall be under no  obligation to contest any such  payment.  Sublandlord  shall,
however,  at the written request of Subtenant,  furnish to Subtenant evidence of
such payment.

         11.3.  Subtenant shall also pay to Sublandlord any "Tenant  Surcharges"
(as that term is hereinafter  defined).  "Tenant  Surcharges" shall mean any and
all amounts other than Fixed Rent,  Section 4.3 Rent and Section 4.4 Rent which,
by the  terms  of the  Overlease,  become  due and  payable  by  Sublandlord  to
Overlandlord as additional rent or otherwise and which would not have become due
and payable but for the acts,  requests for services,  and/or failures to act of
Subtenant,  its  agents,   officers,   representatives,   employees,   servants,
contractors, invitees, licensees or visitors under this Sublease, including, but
not  limited  to:  (i) any  increases  in  Overlandlord's  fire,  rent or  other
insurance  premiums,  as provided in Article 6 of the Overlease,  resulting from
any act or omission of Subtenant,  (ii) any additional charges to Sublandlord on



                                       12
<PAGE>

account of Subtenant's  use of heating,  ventilation or air  conditioning  after
hours,  (iii) any charges  which may be imposed on  Sublandlord  pursuant to the
Overlease,  to the extent that such charges are  attributable to the Premises or
the use  thereof  or  services  or  utilities  provided  thereto,  and  (iv) any
additional  charges to Subtenant on account of  Subtenant's  use of cleaning and
elevator services after hours or in excess of normal usage.  Within a reasonable
time after  receipt by  Sublandlord  of any  statement  or written  demand  from
Overlandlord,   including  any  Tenant  Surcharges,   Sublandlord  will  furnish
Subtenant with a copy of such statement or demand,  together with  Sublandlord's
statement of the amount of any such Tenant  Surcharges,  and Subtenant shall pay
to Sublandlord the amount of such Tenant  Surcharges  within five (5) days after
Subtenant's receipt of such statement or demand; provided,  however, that in any
instance in which  Subtenant shall receive any such statement or demand directly
from  Overlandlord,  Subtenant  may pay  the  amount  of the  same  directly  to
Overlandlord.   Payments   shall  be  made   pursuant  to  this   Section   11.3
notwithstanding  the fact that the  statement to be provided by  Sublandlord  is
furnished to Subtenant  after the  expiration  of the term of this  Sublease and
notwithstanding  the fact that by its terms this Sublease  shall have expired or
have been cancelled or terminated.

         12.

         12.1. Any notice,  demand or  communication  which,  under the terms of
this Sublease or under any statute or municipal  regulation must or may be given
or made by the parties hereto,  shall be in writing and given or made by mailing
the same by registered or certified mail, return receipt requested, addressed to
the party for whom intended at its address as aforesaid,  except that, after the
Sublease  Commencement  Date,  Subtenant's  address  shall be



                                       13
<PAGE>

deemed to be the Building  unless  Subtenant  shall give notice to the contrary.
Either party,  however,  may  designate  such new or other address to which such
notices, demands or communications  thereafter shall be given, made or mailed by
notice  given in the  manner  prescribed  herein.  Any such  notice,  demand  or
communication  shall be deemed given or served,  as the case may be, on the date
of the posting thereof.

         13.

         13.1.  Subtenant shall pay to Sublandlord 4.473% of the charges payable
under Section 5.2.2 of the Overlease for electricity.

         13.2.  Subtenant's use of electric current in the Premises shall not at
any time exceed the capacity of any of the  electrical  conductors and equipment
in or otherwise serving the Premises.

         13.3.  Sublandlord  shall not be liable in any way to Subtenant for any
failure or defect in the supply or character of electric energy furnished to the
Premises by reason of any  requirement,  act or  omission of the public  utility
serving the Building with  electricity or for any other reason not  attributable
to Sublandlord.

         14.

         14.1.   Subtenant   may  make  no  changes,   alterations,   additions,
improvements or decorations in, to or about the Premises without  Overlandlord's
and Sublandlord's prior written consent.

         15.

         15.1.  Subtenant  agrees to look  solely to  Sublandlord's  estate  and
interest in this Sublease,  and the Premises,  for the satisfaction of any right
or remedy of  Subtenant  for the



                                       14
<PAGE>

collection of a judgment (or other  judicial  process)  requiring the payment of
money by Sublandlord, in the event of any liability by Sublandlord, and no other
property  or  assets  of  Sublandlord  shall  be  subject  to  levy,  execution,
attachment,  or other enforcement  procedure for the satisfaction of Subtenant's
remedies under or with respect to this Sublease, the relationship of Sublandlord
and Subtenant  hereunder,  or Subtenant's use and occupancy of the Premises,  or
any other liability of Sublandlord to Subtenant.

         16.

         16.1.  So long as Subtenant  pays all of the Fixed Rent and  additional
rent due under this Sublease and performs all of Subtenant's  other  obligations
hereunder,  Sublandlord  shall not disturb or  terminate  Subtenant's  leasehold
estate hereunder,  subject, however, to the terms, provisions and obligations of
this Sublease and the Overlease.

         17.

         17.1. This Sublease may not be changed orally, but only by an agreement
in writing signed by the party against whom  enforcement of any waiver,  change,
modification or discharge is sought.

         17.2.  This Sublease shall not be binding upon  Sublandlord  unless and
until it is signed by Sublandlord and delivered to Subtenant.  This Section 17.2
shall not be deemed to modify the provisions of Article 6 hereof.

         17.3.  This  Sublease  constitutes  the entire  agreement  between  the
parties and all representations and understandings have been merged herein.

         17.4.  This  Sublease  shall inure to the benefit of all of the parties
hereto, their successors and (subject to the provisions hereof) their assigns.



                                       15
<PAGE>


         17.5. The term  "Sublandlord"  as used in this Sublease shall mean only
the  Sublandlord  named  herein,  so that in the event of any  assignment of the
Sublease, the Sublandlord named herein shall be and hereby is entirely freed and
relieved of all future  covenants,  obligations  and  liabilities of Sublandlord
hereunder,  and it shall be  deemed  and  construed  without  further  agreement
between the parties or their  successors  in interest  that the  assignee of the
Sublease  has  assumed  and  agreed  to carry  out any and all  such  covenants,
obligations and liabilities of Sublandlord hereunder.

         18.

         18.1. Subject to the Sublease  Expiration Date set forth in Section 1.1
hereof,  either  Sublandlord or Subtenant may elect, at its option, to terminate
this Sublease and the term and estate hereby granted,  by written notice of such
termination  (hereinafter called the "Sublease Termination Notice") to the other
party,  which Sublease  Termination  Notice shall contain a surrender date (such
date being hereinafter  called the "Sublease  Surrender  Date"),  which Sublease
Surrender  Date shall be the last day of the month  designated  in the  Sublease
Termination  Notice  which shall be not less than six (6) months  following  the
date on which such Sublease Termination Notice is given.

         18.2. In the event of the giving of such Sublease Termination Notice by
either  Sublandlord  or Subtenant,  this Sublease and the term and estate hereby
granted  (unless  the same  shall have  expired  sooner  pursuant  to any of the
conditions  of  limitation  or other  provisions of this Sublease or pursuant to
law) shall  terminate on the Sublease  Surrender Date with the same effect as if
such date were the date hereinbefore specified for the expiration of the term of
this



                                       16
<PAGE>

Sublease,  and the  Fixed  Rent and other  charges  payable  hereunder  shall be
apportioned as of the Sublease Surrender Date.

         19.

         19.1.  Subtenant has deposited  with  Sublandlord on the date hereof an
amount  equal  to  $6,174.77  as  security  for  the  faithful  performance  and
observance by Subtenant of the terms,  provisions,  covenants and  conditions of
this Sublease.  It is agreed that in the event Subtenant  defaults in respect to
any of the  terms,  provisions,  covenants  and  conditions  of  this  Sublease,
including,  but not limited to, the payment of Fixed Rent and  additional  rent,
Sublandlord  may use,  apply or retain the whole or any part of the  security so
deposited  to the  extent  required  for  the  payment  of any  Fixed  Rent  and
additional  rent or any other sum as to which Subtenant is in default or for any
sum  which  Sublandlord  may  expend or may be  required  to expend by reason of
Subtenant's  default in respect of any of the terms,  provisions,  covenants and
conditions  of this  Sublease,  including,  but not  limited  to, any damages or
deficiency  accrued  before or after summary  proceedings  or other  re-entry by
Sublandlord.  In the event that Subtenant shall fully and faithfully comply with
all of the terms,  provisions,  covenants and conditions of this  Sublease,  the
security  shall be returned to Subtenant  after the date fixed as the end of the
Sublease and after delivery of entire possession of the Premises to Sublandlord.
In the event of an assignment of the Sublease,  Sublandlord shall have the right
to transfer the security to the  assignee  and  Sublandlord  shall ipso facto be
released by Subtenant  from all liability for the return of such  security;  and
Subtenant  agrees to look solely to the new  sublandlord  for the return of said
security;  and it is agreed  that the  provisions  hereof  shall  apply to every
transfer or  assignment  made of the  security to a new  sublandlord.  Subtenant
further  covenants  that it will



                                       17
<PAGE>

not assign or  encumber or attempt to assign or  encumber  the monies  deposited
herein as security and that neither  Sublandlord  nor its  successors or assigns
shall be bound by any such  assignment,  encumbrance,  attempted  assignment  or
attempted  encumbrance.  In the event Sublandlord applies or retains any portion
or all of the security deposited,  Subtenant shall restore the amount so applied
or retained within 3 days after the application thereof so that at all times the
amount deposited hereunder shall be equal to the amount set forth above.

         19.2.  Sublandlord  shall  deposit the security in an  interest-bearing
account at Fleet Bank, and the interest earned thereon,  less an  administrative
fee of one (1%) percent per annum of  principal,  shall be credited to Subtenant
annually.

         20.

         20.1.  Sublandlord  represents  that to the best of its knowledge there
are no  Hazardous  Materials  (as  hereinafter  defined)  within  the  Premises.
Sublandlord  agrees to indemnify  and hold  Subtenant  harmless from any expense
paid or incurred in connection  with the  investigation,  removal,  containment,
replacement, enclosure, encapsulation, abatement, remediation or other treatment
or repairs or cleaning of areas (herein  collectively  called  "remediation") in
connection  with the  presence of  Hazardous  Materials  in the  Premises to the
extent that such remediation is made necessary by Sublandlord's use or manner of
use of the  Premises and required  under Legal  Requirements  existing as of the
date hereof. For purposes hereof, the term "Hazardous  Materials" shall mean any
flammable explosives,  radioactive  materials,  hazardous wastes,  hazardous and
toxic  substances,  or related  materials,  asbestos or any material  containing
asbestos, or any other substance or material,  as defined by any federal,  state
or local environmental law, ordinance,  rule or regulation,  including,  without
limitation, the



                                       18
<PAGE>

Comprehensive  Environmental Response Compensation and Liability Act of 1980, as
amended,  the Hazardous Materials  Transportation Act, as amended,  the Resource
Conservation  and Recovery Act, as amended,  and in the regulations  adopted and
publications promulgated pursuant to each of the foregoing.  Hazardous Materials
shall not include normal cleaning and/or normal office substances or materials.

         IN WITNESS WHEREOF, the parties have hereunto set their hands and seals
as of the day and year first above written.

                                     INTERNEURON PHARMACEUTICALS, INC.,
                                        Sublandlord

                                     By: ________________________________
                                         Name:
                                         Title:

                                     GENTA, INC., Subtenant

                                     By: ________________________________
                                         Name:
                                         Title:



                                       19
<PAGE>

STATE OF MASSACHUSETTS  )
                        :  ss.:
COUNTY OF MIDDLESEX     )

         On the ____ day of April,  1999, before me personally came _______,  to
me known,  who,  being by me duly  sworn,  did depose and say that he resides in
_______________ ______________; that he is the _________________ of GENTA, INC.,
the corporation  described in and which executed the above instrument;  and that
he  signed  his  name  thereto  by  order  of the  board  of  directors  of said
corporation.

                                            ____________________________________
                                                         Notary Public



                                       20
<PAGE>


                                    EXHIBIT A

                                    Overlease

                    (Copy of Overlease to be annexed hereto)


<PAGE>


                                    EXHIBIT B

                           Floor Plan of 200 Premises

                                (TO BE ATTACHED)




                                                                  EXECUTION COPY

                            ASSET PURCHASE AGREEMENT

                           dated as of March 19, 1999,

                                  by and among

                          JBL SCIENTIFIC INCORPORATED,

                                 as the Seller,

                               GENTA INCORPORATED,

                          as Shareholder and Guarantor,

                                       and

                             JBL ACQUISITION CORP.,

                                  as the Buyer


<PAGE>

                                TABLE OF CONTENTS

                                                                        Page

ARTICLE I PURCHASE AND SALE OF ASSETS.....................................2
     1.1         Defined Terms............................................2
     1.2         Purchased Assets.........................................2
     1.3         Excluded Assets..........................................4
     1.4         Closing..................................................5
     1.5         Assets Not Assignable....................................5

ARTICLE II PURCHASE PRICE.................................................6
     2.1         Payment of the Purchase Price............................6
     2.2         Post-Closing Adjustment to Preliminary Purchase Price....6
     2.3         Purchase Price Allocation................................8
     2.4         Sales and Transfer Taxes.................................8
     2.5         Prorations...............................................8

ARTICLE III LIABILITIES...................................................8
     3.1         Assumption of Liabilities................................8
     3.2         Non-Assumption of Liabilities............................9
     3.3         Employee Benefit Plans...................................9

ARTICLE IV REPRESENTATIONS AND WARRANTIES OF THE SELLER AND SHAREHOLDER..10
     4.1         Ownership, Organization and Qualification...............10
     4.2         Authorization...........................................10
     4.3         Enforceability..........................................10
     4.4         Conflicting Obligations.................................10
     4.5         Subsidiaries............................................11
     4.6         Title to Assets.........................................11
     4.7         Third Party Consents....................................11
     4.8         Organizational Documents................................11
     4.9         Financial Statements....................................11
     4.10        Real Property; Leases...................................11
     4.11        Personal Property.......................................12
     4.12        All Necessary Assets....................................12
     4.13        Receivables.............................................12
     4.14        Inventories.............................................13
     4.15        Intellectual Property...................................13
     4.16        Insurance...............................................15
     4.17        Permits.................................................15
     4.18        Material Contract.......................................16
     4.19        Litigation..............................................17
     4.20        Compliance With Law.....................................17
     4.21        Environmental Matters...................................17


                                      -i-


<PAGE>

     4.22        Contingent and Undisclosed Liabilities..................18
     4.23        Tax Matters.............................................19
     4.24        Employees; Labor Matters................................19
     4.25        Employee Benefit Plans..................................20
     4.26        Products Liability......................................21
     4.27        Product Warranty........................................21
     4.28        Events Subsequent to Latest Fiscal Year End.............21
     4.29        Customers and Suppliers.................................23
     4.30        Brokerage...............................................23
     4.31        Affiliate Transactions..................................24
     4.32        Guaranties..............................................24
     4.33        Investment..............................................24
     4.34        Commission Filings......................................24
     4.35        Amersham Termination....................................25
     4.36        Representations and Warranties True and Correct.........25

ARTICLE V REPRESENTATIONS OF THE BUYER...................................25
     5.1         Ownership, Organization and Qualification...............25
     5.2         Authorization...........................................25
     5.3         Enforceability..........................................26
     5.4         Conflicting Obligations.................................26
     5.5         Litigation..............................................26
     5.6         Brokerage...............................................26

ARTICLE VI COVENANTS OF THE SELLER AND THE SHAREHOLDER...................26
     6.1         Access..................................................26
     6.2         Operation of Business...................................27
     6.3         Preservation of Business................................27
     6.4         Insurance and Maintenance of Property...................27
     6.5         Compliance with Laws....................................27
     6.6         Supplemental Disclosure.................................27
     6.7         Fulfill Conditions......................................28
     6.8         Employees...............................................28
     6.9         Release of Liens........................................28
     6.10        Change of Corporate Name................................28
     6.11        Documents of Transfer...................................28
     6.12        Nondisclosure and Noncompetition Agreement..............28
     6.13        Other Deliveries........................................28
     6.14        Collection of the Receivables...........................29
     6.15        Exclusive Dealing.......................................29
     6.16        Further Assurances......................................29
     6.17        Brokerage...............................................30
     6.18        Quality Assurance Agreement.............................30
     6.19        Intellectual Property Assignments.......................30
     6.20        Lipid License Agreement.................................30
     6.21        Biogenex License Agreement..............................30


                                      -ii-


<PAGE>

     6.22        Note....................................................30
     6.23        On-Site Contamination...................................31
     6.24        The Seller's Welfare Plans..............................31
     6.25        The Seller's 401(k) Plan................................31

ARTICLE VII COVENANTS OF THE BUYER.......................................32
     7.1         Certified Resolutions...................................32
     7.2         Assignment, Bill of Sale and Assumption Agreement.......32
     7.3         Nondisclosure and Noncompetition Agreement..............32
     7.4         Quality Assurance Agreement.............................32
     7.5         Lipid License Agreement.................................32
     7.6         Note....................................................32
     7.7         Lease...................................................32
     7.8         Employees...............................................32
     7.9         Preservation of Records.................................33
     7.10        Uncollectible Receivables...............................33
     7.11        Access to Property......................................33
     7.12        The Buyer's 401(k) Plan.................................34
     7.13        The Buyer's Welfare Plans...............................34
     7.14        Employment Terms and Benefits after the Closing Date....35
     7.15        Product Liability Claims................................35
     7.16        Minimum Net Book Value..................................35

ARTICLE VIII CONDITIONS OF THE BUYER'S OBLIGATION TO CLOSE...............35
     8.1         Representation and Warranties...........................35
     8.2         Performance of Covenants and Obligations................36
     8.3         Proceedings and Instruments Satisfactory................36
     8.4         Adverse Change..........................................36
     8.5         No Litigation...........................................36
     8.6         Consents, Approvals, Certifications, Licenses 
                    and Permit...........................................36
     8.7         Good Standing Certificates..............................36
     8.8         Opinion of Counsel......................................36
     8.9         Due Diligence...........................................37
     8.10        Approval by the Shareholder's Shareholders..............37
     8.11        Lease...................................................37

ARTICLE IX CONDITIONS TO THE SELLER'S OBLIGATION TO CLOSE................37
     9.1         Representations and Warranties..........................37
     9.2         Performance of Covenants and Obligations................37
     9.3         Proceedings and Instruments Satisfactory................37
     9.4         No Litigation...........................................37
     9.5         Opinion of Counsel......................................38

ARTICLE X INDEMNIFICATION BY SELLER AND SHAREHOLDER......................38
     10.1        Indemnification.........................................38
     10.2        Procedures for Making Claims............................38


                                     -iii-


<PAGE>

     10.3        Participation in Defense of Third Party Claims..........39
     10.4        Survival of Representations and Indemnification.........39
     10.5        Limitations on Indemnifiable Damages....................40
     10.6        Offset..................................................40
     10.7        Other Indemnification Provisions........................40

ARTICLE XI INDEMNIFICATION BY BUYER......................................41
     11.1        Indemnification.........................................41
     11.2        Procedures for Making Claims............................41
     11.3        Participation in Defense of Third Party Claims..........42
     11.4        Survival of Indemnification.............................42
     11.5        Limitations on Indemnifiable Damages....................43
     11.6        Offset..................................................43
     11.7        Other Indemnification Provisions........................43

ARTICLE XII TERMINATION..................................................44
     12.1        Rights to Terminate.....................................44
     12.2        Effects of Termination..................................44

ARTICLE XIII GUARANTEE...................................................44
     13.1        Guarantee by the Shareholder............................44
     13.2        Guarantee by Promega....................................45

ARTICLE XIV DEFINITIONS..................................................45
     14.1        Certain Defined Terms...................................45
     14.2        Interpretation..........................................53
     14.3        Other Terms.............................................53

ARTICLE XV MISCELLANEOUS.................................................53
     15.1        Survival of Representations and Warranties..............53
     15.2        Benefit and Assignment..................................53
     15.3        Governing Law...........................................53
     15.4        Expenses................................................53
     15.5        Notices.................................................53
     15.6        Counterparts............................................54
     15.7        Headings................................................54
     15.8        Amendment, Modification and Waiver......................54
     15.9        Entire Agreement........................................54
     15.10       Third-Party Beneficiaries...............................55
     15.11       Publicity...............................................55


                                      -iv-


<PAGE>


EXHIBITS:
     Exhibit A-1    Form of Legal Opinion of Kramer Levin Naftalis & Frankel LLP
     Exhibit A-2    Form of Legal Opinion of Sinsheimer, Schiebelhut & Baggett
     Exhibit A-3    Form of Legal Opinion of Michael Best & Friedrich LLP
     Exhibit B      Form of Assignment, Bill of Sale and Assumption Agreement
     Exhibit C-1    Form of Seller Intellectual Property Assignment
     Exhibit C-2    Form of Shareholder Intellectual Property Assignment
     Exhibit D      Summary of Lease Terms
     Exhibit E      Form of Lipid License Agreement
     Exhibit F      Form of Nondisclosure and Noncompetition Agreement
     Exhibit G      Form of Note
     Exhibit H      Form of Quality Assurance Agreement

SCHEDULES:
     Schedule 1.2(e) - Real Estate
     Schedule 1.2(f) - Equipment
     Schedule 1.2(g) - Vehicles
     Schedule 1.3(h) - Shareholder  Tangible  Personal  Property 
     Schedule 1.3(n) - Excluded  Assets  
     Schedule 2.3 - Purchase Price  Allocation
     Schedule 4.5 -  Subsidiaries  
     Schedule 4.7 - Third Party  Consents
     Schedule 4.8 -  Organization  Documents  
     Schedule 4.9 -  Financial Statements  
     Schedule 4.10(a) - Real Estate 
     Schedule 4.11 - Personal Property 
     Schedule 4.13 - Receivables 
     Schedule 4.15(b) - Infringement of Intellectual Property 
     Schedule 4.15(c) - Patents 
     Schedule 4.15(d) - Permits  
     Schedule 4.15(e) -  Misappropriation  
     Schedule 4.16(a) - Insurance  Policies  
     Schedule 4.16(c) - Insurance  Claims  
     Schedule 4.16(d) -  Self-Insurance  
     Schedule 4.17 - Permits  
     Schedule 4.18 - Material  Contracts and Other Descriptions and Lists 
     Schedule 4.19 - Litigation  
     Schedule 4.20 - Compliance  With Law 
     Schedule 4.21(a) - Environmental Compliance 
     Schedule 4.21(c) - Environmental Litigation
     Schedule 4.21(d) - Disposal  Practices  
     Schedule 4.24(a) - Employees
     Schedule 4.25(a) - Employee Benefit Plans 
     Schedule 4.25(g) - Family and Medical  Leave Act 
     Schedule 4.28 - Subsequent  Events  


                                      -v-


<PAGE>

     Schedule 4.29 - Customers  and Suppliers  
     Schedule 4.30 - Brokerage  
     Schedule 4.31 - Affiliate  Transactions 
     Schedule 4.33 - Bank Accounts;  Power of Attorney; Other 
     Schedule 7.8 - Retained Employees


                                      -vi-


<PAGE>

                            ASSET PURCHASE AGREEMENT


            THIS ASSET PURCHASE  AGREEMENT (this "Agreement") is entered into as
of the 19th day of March,  1999, by and among JBL ACQUISITION CORP., a Wisconsin
corporation (the "Buyer"), JBL SCIENTIFIC INCORPORATED, a California corporation
(the "Seller"), and GENTA INCORPORATED,  a Delaware corporation,  being the sole
shareholder of the Seller (the "Shareholder").

                                    RECITALS

            WHEREAS,  the Seller is engaged in the development,  manufacture and
sale  of  specialty  chemical  products,  including  DNA  reagents  used  in the
synthesis of oligomers (the "Business");

            WHEREAS,  the Seller leases and uses certain real property and owns,
leases and uses certain  tangible and  intangible  assets used in the  Business,
including,   without   limitation,    intellectual   property,   buildings   and
improvements,  machinery and equipment, vehicles, inventory, contract rights and
prepaid expenses and receivables;

            WHEREAS,  the Buyer desires to purchase all of the assets related to
the Business other than the Excluded Assets referred to below and to assume only
certain  specific  liabilities  associated  with the  Business,  and the  Seller
desires to sell and  transfer to the Buyer those assets and  liabilities,  while
retaining  environmental and all other liabilities,  all as more fully set forth
below;

            WHEREAS,  the  Shareholder,  in  consideration  of the sale of those
assets  and the  assumption  of  those  liabilities,  agrees  to be party to the
Agreement  and  to  guarantee  the  Seller's  performance  and  each  and  every
obligation of the Seller under this Agreement and the transactions  contemplated
hereby; and

            WHEREAS,  Promega Corporation,  a Wisconsin corporation ("Promega"),
in  consideration  of the purchase of those assets and the  assumption  of those
liabilities,  is willing to guarantee the Buyer's  payment of the Purchase Price
(as defined by below), including the payments of obligations under the Note, the
Buyer's  obligations  under  the  Lease  (as  defined  below)  and  the  Buyer's
obligations under the Quality Assurance Agreement.

            NOW,  THEREFORE,  in consideration of the foregoing recitals and the
mutual  agreements  and  covenants  contained  herein,  and for  other  good and
valuable  consideration,  the  receipt  and  sufficiency  of  which  are  hereby
acknowledged,  the Buyer, Promega, the Seller and the Shareholder,  hereby agree
as follows:


<PAGE>

                                    ARTICLE I

                           PURCHASE AND SALE OF ASSETS

            1.1 Defined Terms.  Capitalized  terms used herein have the meanings
set forth in Section 13.1.

            1.2 Purchased  Assets.  Subject to the terms and  conditions of this
Agreement, and in reliance upon the representations,  warranties,  covenants and
agreements  made in this Agreement by the Buyer,  the Seller and the Shareholder
(1) the Buyer shall purchase, accept and acquire from the Seller, and the Seller
shall sell, transfer, convey, assign and deliver to the Buyer, all of its right,
title and  interest  in and to the assets  and  properties  of the  Seller  (but
excluding  Excluded Assets) used or held in the conduct of or in connection with
the Business,  whether  tangible or  intangible,  real,  personal or mixed,  and
wherever  located  (the  "Seller  Purchased  Assets"),  and (2) the Buyer  shall
purchase,  accept and acquire from the  Shareholder,  and the Shareholder  shall
sell, transfer, convey, assign and deliver to the Buyer, all of its right, title
and interest in and to the assets and properties of the Shareholder specified in
Section 1.2(o) (the  "Shareholder  Purchased  Assets";  together with the Seller
Purchased Assets, the "Purchased Assets"). The Purchased Assets include, without
limitation,  the Seller's or, in the case of Section 1.2(o),  the  Shareholder's
right, title and interest in and to the following,  except as otherwise provided
in Sections 1.3, 1.5 and 3.3.

          (a)  All  Intellectual   Property  of  the  Seller  and  all  goodwill
               associated  with the  foregoing,  all  goodwill  associated  with
               respect  thereto,  licenses and sublicenses  granted and obtained
               with  respect  thereto and rights  thereunder,  remedies  against
               infringements  thereof  and  rights to  protection  of  interests
               therein under the laws of all jurisdictions;

          (b)  All retail and  non-retail  inventories of the Seller of whatever
               kind,  including,  without  limitation,   merchandise,  supplies,
               accessories,  finished goods,  work-in-process  and raw materials
               (the "Inventories");

          (c)  All present and future  rights of the Seller to payment for goods
               sold or services  rendered  whether or not earned by performance,
               including,   without   limitation,   trade  and  other   accounts
               receivable, all notes receivable and all other amounts receivable
               (the "Receivables");

          (d)  All prepaid expenses,  advance  payments,  deposits and rights to
               receive discounts, refunds, rebates, awards and the like;

          (e)  All leaseholds and subleaseholds, and improvements,  fixtures and
               appurtenances  thereto,  including,  without  limitation,  leases
               relating  to the  parcels of land with the legal  description  of
               which  is   described   on  Schedule   1.2(e)   attached   hereto
               (collectively, the "Real Estate");

          (f)  All  equipment   (building  or  office),   machinery,   reactors,
               lyophilizers,   chemical  manufacturing  equipment,   prototypes,
               parts, components,  projects in process,  


                                      -2-


<PAGE>

               furniture, appliances, artwork, computers, computer terminals and
               printers, telephone systems, telecopiers and photocopiers, office
               supplies  and  office  equipment  and  other  tangible   personal
               property of every kind and description, which are owned or leased
               by the Seller,  or are utilized in connection with the operations
               of the  Business  upon or  within  the  Real  Estate,  including,
               without  limitation,   those  items  listed  on  Schedule  1.2(f)
               attached  hereto,  but excluding the Inventories and the Vehicles
               (the "Equipment");

          (g)  All motor vehicles,  including,  without limitation, those listed
               on Schedule 1.2(g) attached hereto (the "Vehicles");

          (h)  All contracts, leases, subleases,  arrangements,  commitments and
               other  agreements of the Seller (other than the Granada  Leases),
               including,  without limitation,  all customer agreements,  vendor
               agreements,   purchase   orders,   installation  and  maintenance
               agreements,  hardware lease or rental agreements, contract claims
               and all other  arrangements  and  understandings  related  to the
               Business,  including,  without limitation,  those items which are
               listed on Schedule 4.18 (the "Contracts");

          (i)  All   qualifications,    registrations,    filings,   privileges,
               franchises,  immunities,  licenses,  permits,  authorizations and
               approvals issued by Governmental  Authorities to the Seller which
               are used or  required  in order for the Seller to own and operate
               the Business,  including, without limitation, all certificates of
               occupancy  and  certificates,  licenses  and permits  relating to
               zoning, building,  housing, safety,  Environmental Laws, fire and
               health (the "Permits");

          (j)  All Records;

          (k)  All  sales,  marketing  and  expansion  plans,  strategic  plans,
               projections,  studies,  reports  and  other  documents  and  data
               (including, without limitation,  creative materials,  advertising
               and promotional  matters and current and past lists of customers,
               suppliers,  vendors and sources) related to the Business, and all
               training  materials  and  marketing   brochures  related  to  the
               Business;

          (l)  The Seller's goodwill related to the Business;

          (m)  All of the  Seller's  rights  and  remedies,  under  warranty  or
               otherwise, against a manufacturer, vendor or other Person for any
               defects in any Purchased Asset;

          (n)  All  deposits  held by the Seller with  respect to services to be
               performed or products to be delivered after the Closing;

          (o)  All patents,  patent applications and other Intellectual Property
               of  the  Shareholder  set  forth  in  the  Intellectual  Property
               Assignment made by the Shareholder in favor of the Buyer;

          (p)  All other properties,  assets and rights of every kind, character
               or  description  which 


                                      -3-


<PAGE>


               are owned by the Seller and which are not Excluded Assets; and

          (q)  All  causes of action,  choses in action  and rights of  recovery
               with respect to any of the foregoing.

            1.3 Excluded Assets. The Purchased Assets shall not include, and the
Seller shall retain, the following assets (the "Excluded Assets"):

          (a)  The Seller's rights under this Agreement;

          (b)  The  Seller's  minute  books,   stock  record  books,   corporate
               franchise  and   authorizations  to  do  business  as  a  foreign
               corporation and tax returns;

          (c)  The Seller's cash and cash equivalents;

          (d)  The Seller's environmental policies and procedures;

          (e)  All bank or investment accounts of the Seller;

          (f)  All  causes of action,  choses in action  and rights of  recovery
               that may arise in connection  with the discharge by the Seller of
               any Excluded  Liability or rights of recovery or  contribution in
               respect of any Excluded Liability;

          (g)  Any claims of the Seller  for  refunds of income and other  taxes
               attributable to periods prior to the closing;

          (h)  All  tangible   personal  property  of  the  Shareholder  in  the
               possession  of the  Seller,  all of which is listed  on  Schedule
               1.3(h);

          (i)  All Records relating to Excluded Assets or Excluded Liabilities;

          (j)  Any  Intellectual  Property and know-how  related to  therapeutic
               applications of antisense  technology,  including but not limited
               to, manufacturing, storage, packaging, handling, distribution and
               quality control  information  related to compound G3139;  control
               oligonucleotides related to G3139; phosphorothioates and modified
               backbone  structures  and  components  thereof  related to G3139;
               analytical  testing  and  control  information  relating  to such
               compounds;  stability  information  and  information  relating to
               preclinical   and  clinical   development  and  testing  of  such
               compounds; and all written Records pertaining to the above;

          (k)  The Granada Leases;

          (l)  Employee-related assets not being assumed by the Buyer;

          (m)  All insurance policies of the Seller;


                                      -4-


<PAGE>

          (n)  All assets listed on Schedule 1.3(n); and

          (o)  All rights and obligations under the Granada Leases.

            Nothing in this  Section  1.3 shall  prevent the  concurrent  use of
know-how by the Buyer to the extent such  know-how is necessary  and  sufficient
for the Buyer to assume control of and to conduct the Business.

            1.4 Closing. The closing (the "Closing") of the purchase and sale of
the Purchased  Assets shall take place at 10:00 a.m., local time, on the Closing
Date, at the offices of Michael Best & Friedrich LLP, One South Pinckney Street,
Suite 700,  Madison,  Wisconsin 53703, or at such other time and place as may be
mutually  agreed to by the Buyer and the Seller.  The  "Closing  Date" means the
second  business day following the  satisfaction  or waiver of all conditions to
the  obligations  of the parties to  consummate  the  transactions  contemplated
hereby (other than conditions with respect to action the respective parties will
take at the  Closing),  or such other date as may be  mutually  agreed to by the
Buyer and the Seller.  The Closing  shall be  effective  as of 12:01 a.m. on the
Closing Date; provided, however, that the Buyer shall have no further obligation
under this  Agreement if the  conditions set forth in Article VIII have not been
satisfied  by the Seller or  expressly  waived by the Buyer on or before May 15,
1999.

             1.5 Assets Not Assignable.

            (a) To the extent that any interest in any of the  Purchased  Assets
is not capable of being assigned,  transferred or conveyed  without the consent,
waiver or authorization of any Person and that consent,  waiver or authorization
is not  obtained,  or if such  assignment,  transfer or  conveyance or attempted
assignment,  transfer or conveyance would constitute a breach of any Contract or
other  Purchased  Asset,  or a  violation  of any law,  statute,  decree,  rule,
regulation  or  other  governmental  edict  or is not  immediately  practicable,
notwithstanding  anything to the contrary contained herein, this Agreement shall
not  constitute an assignment,  transfer or conveyance of such  interest,  or an
attempted  assignment,  transfer or conveyance of such interest (such  interests
being  hereinafter  collectively  referred to as  "Restricted  Interests").  The
entire  beneficial  interest in any Purchased Assets subject to a restriction as
described  above,  and any other  interest in such Purchased  Assets,  which are
transferable  notwithstanding  such  restriction,  shall be transferred from the
Seller to the Buyer as provided in this Section 1.5.

            (b) Anything in this Agreement to the contrary notwithstanding,  the
Seller shall not be obligated to transfer to the Buyer any Restricted  Interests
without the Buyer or the Seller first having obtained all consents,  waivers and
authorizations  necessary for such transfers.  In consultation with the Buyer as
to the  practicalities of proposed actions,  the Seller shall use its reasonable
efforts  to  assist  the  Buyer  in  obtaining   such   consents,   waivers  and
authorizations and to resolve any  impracticalities of assignment referred to in
Section 1.5(a) hereof.

            (c) To the extent  that the  consents,  waivers  and  authorizations
referred  to in  Section  1.5(a)  hereof  are not  obtained  by the Buyer or the
Seller,  or until the  impracticalities  of  transfer  referred  to therein  are
resolved,  the Seller shall use reasonable  efforts to (i) provide to the Buyer,
at the request of the Buyer and at the  Seller's  expense,  the  benefits of any
Restricted  


                                      -5-


<PAGE>

Interests,  (ii)  cooperate in reasonable  and lawful  arrangements  designed to
provide  such  benefits  to the Buyer and (iii)  enforce,  at the request of the
Buyer for the account of the Buyer,  any rights of the Seller  arising  from any
Restricted  Interests  (including  the right to elect to terminate in accordance
with the terms thereof upon the request of the Buyer).

                                   ARTICLE II

                                 PURCHASE PRICE

             2.1 Payment of the Purchase Price.

            (a) The payment by the Buyer to the Seller for the Purchased  Assets
on the Closing Date (the "Preliminary  Purchase Price") shall be SIX MILLION TWO
HUNDRED  THOUSAND  DOLLARS  ($6,200,000)  payable  on the  Closing  Date  in the
following manner:

                     (i)    The delivery of the Note in an  aggregate  principal
                            amount of ONE MILLION TWO HUNDRED  THOUSAND  DOLLARS
                            ($1,200,000);

                     (ii)   TWO HUNDRED FIFTY THOUSAND DOLLARS ($250,000) of the
                            Preliminary Purchase Price (the "Adjustment Amount")
                            shall be retained by the Buyer until any  adjustment
                            to the  Preliminary  Purchase Price is determined in
                            accordance with Section 2.2; and

                     (iii)  The balance of the Preliminary  Purchase Price shall
                            be paid in cash to the Seller.

             (b) The amounts paid in cash pursuant to Section 2.1(a) shall be by
wire transfer of same-day funds to an account designated in writing to the Buyer
by the Seller prior to the Closing.

             2.2 Post-Closing Adjustment to Preliminary Purchase Price.

             (a) Purchase  Price  Adjustment.  The  Preliminary  Purchase  Price
assumes the Net Book Value of the  Purchased  Assets on the Closing Date will be
at least $1,768,000 (the "Estimated Net Book Value").  The Preliminary  Purchase
Price  shall be reduced  on a  dollar-for-dollar  basis by the  amount  that the
actual Net Book Value of the Purchased Assets  determined as of the Closing Date
and reflected on the Closing  Balance Sheet (the "Final Net Book Value") is less
than the Estimated Net Book Value. The Preliminary Purchase Price, as reduced by
this Section 2.2, is the "Purchase Price."

             (b) Net Book Value. As used herein, the term "Net Book Value" shall
mean the book value of the Purchased  Assets  calculated in accordance with GAAP
on a basis consistent with the preparation of the Financial  Statements less the
value  of the  Operating  Accruals;  provided,  however,  the  Purchased  Assets
acquired  pursuant  to the  Biogenex  License  Agreement  shall not  include any
increases in the assets  attributable  to any  payments  made under such license
after December 31, 1998;  provided,  further,  such definition is modified as to
Inventories as set forth in 


                                      -6-


<PAGE>

the following sentence. Inventories shall be valued on the basis of the lower of
cost  (first-in,  first-out)  or market in accordance  with GAAP,  excluding the
following:  (a) all  slow-moving,  obsolete or damaged  merchandise  included in
reserves  established on a basis  consistent with the  Inventories  shown on the
Latest  Balance  Sheet;  (b) items with an  expiration  date prior to the twelve
month  anniversary  of the Closing  Date;  (c) products that do not meet current
quality standards and  specifications  of the Seller;  and (d) finished goods in
quantities  on  hand in  excess  of  quantities  sold  in the  twenty-four  (24)
preceding months up to and including the Closing Date.

             (c) Closing Balance Sheet. Within sixty (60) days after the Closing
Date,  the Buyer shall cause Ernst & Young LLP (the  "Buyer's  Accountants")  to
prepare  a draft  audited  balance  sheet  of the  Business  as of the  close of
business  on the  Closing  Date  in  accordance  with  GAAP  applied  on a basis
consistent  with the  preparation  of the  Financial  Statements  (the  "Closing
Balance  Sheet").  The  Closing  Balance  Sheet  shall  consist  solely of those
Purchased Assets and the Operating  Accruals  normally  included in the Seller's
historical  balance sheets.  For purposes of measuring the carrying value of any
element of the Closing  Balance Sheet,  the assets and  liabilities  referred to
above will be presented as though the transactions  contemplated  herein had not
occurred and in accordance with GAAP consistently applied by the Seller.

             (d)  Dispute   Resolution.   The  Closing  Balance  Sheet  and  any
supporting  documentation  may be  reviewed by a firm of  independent  certified
public  accountants  selected by the Seller  (the  "Seller's  Accountants").  In
connection  with the  preparation  of the  Closing  Balance  Sheet,  the Buyer's
Accountants  shall conduct a physical count of the Inventories as of the Closing
Date. The Seller's Accountants may audit the work papers used in the preparation
of the Closing Balance Sheet, and the Seller shall grant the Buyer's Accountants
full access to all work papers and other  documents and  information  and to all
personnel as may be reasonably requested. If the Seller has any objection to the
draft Closing  Balance Sheet, it shall deliver a detailed  statement  describing
its  objection to the Buyer within  thirty (30) days after  receiving  the draft
Closing Balance Sheet.  The Buyer and the Seller shall meet (if necessary) in an
attempt to  stipulate  to the  purchase  price  adjustment  described in Section
2.2(a) (or  stipulate to such portion  thereof with respect to which there is no
dispute).  If the parties do not agree upon a final  resolution  within  fifteen
(15) days after the Buyer has  received  the  Seller's  objections,  the Buyer's
Accountants and the Seller's  Accountants  shall mutually select a third firm of
independent  public  accountants  (the  "Dispute  Accountants")  to resolve  any
remaining  objections.  The  determination of the Dispute  Accountants  shall be
binding on the parties.  The Buyer and the Seller shall pay equally all fees and
expenses of the Dispute  Accountants.  No party may  unreasonably  withhold  its
consent to the  appointment  as  Dispute  Accountants  of a firm of  independent
accountants suggested by another party.

            (e)  Modification of the Closing Balance Sheet. If the Buyer and the
Seller  agree  upon a  change  to the  Closing  Balance  Sheet,  or the  Dispute
Accountants  determines  that a change  should  be made to the  Closing  Balance
Sheet,  the  Buyer  shall  promptly  cause  the  Buyer's  Accountants  to modify
appropriately the Closing Balance Sheet. All references in this Agreement to the
Closing Balance Sheet, other than in Section 2.2(c), 2.2(d) and 2.2(e), shall be
to the Closing Balance Sheet as initially  prepared by the Buyer and accepted by
the Seller,  or to the Closing  Balance Sheet as modified by the Seller pursuant
to  agreement  of the Buyer and the  Seller or a  determination  of the  Dispute
Accountants, as applicable.

            (f) Payment of Purchase Price  Reduction.  After the Closing Balance
Sheet is in final  


                                      -7-


<PAGE>

form, if the Final Net Book Value reflected on the Closing Balance Sheet is less
than the Estimated Net Book Value,  then the Buyer shall retain such  difference
from the Adjustment  Amount.  If the Final Net Book Value as of the Closing Date
is greater than the Estimated Net Book Value, no adjustment shall be made. After
deducting any adjustments to the Preliminary Purchase Price as set forth in this
Section  2.2(f),  the Buyer shall pay the remainder of the Adjustment  Amount to
the Seller in same day funds on the day following  the date the Closing  Balance
Sheet is in final form. In the event of a dispute  regarding the Closing Balance
Sheet,  any undisputed  amounts shall be promptly paid, and any disputed amounts
shall be promptly paid upon resolution of the dispute.

            2.3 Purchase  Price  Allocation.  The parties  agree to allocate the
Purchase  Price as set forth on Schedule  2.3 for all  federal,  state and local
income  tax  purposes   (including  IRS  Form  8594),  and  will  not  take  any
inconsistent or contrary position therewith for any other purpose.

            2.4 Sales  and  Transfer  Taxes.  The  Seller  shall pay any and all
transfer, sales, purchase, use, value added, excise or similar tax imposed under
the laws of the United States,  or any state or political  subdivision  thereof,
which  arises  out of the  transfer  by the  Seller  to the  Buyer of any of the
Purchased Assets.

             2.5 Prorations.

            (a) Real and personal  property  taxes for the Purchased  Assets for
1999 shall be  prorated on the Closing  Date based upon the taxes  assessed  for
1999; but if the taxes assessed for 1999 are not known on the Closing Date, such
taxes  shall be  prorated  based upon the taxes  assessed  for 1998 and shall be
re-prorated  within ten (10) days after the 1999 tax  assessment  and rate shall
become available with appropriate payment made.

            (b) The Seller shall order final readings for utility services, such
as gas,  electricity,  water and sewer  services,  as of the  Seller's  close of
business  on the day before the  Closing  Date,  and  prorated  charges for such
utility services shall be reflected on the Closing Balance Sheet.

                                   ARTICLE III

                                   LIABILITIES

            3.1 Assumption of Liabilities.  As additional  consideration for the
Purchased  Assets,  the Buyer shall,  on the Closing  Date, by its execution and
delivery of the Assignment,  Bill of Sale and Assumption  Agreement,  assume and
agree to pay when due and perform when required only the following (the "Assumed
Liabilities"):

              (a)    all current  liabilities of the Seller  classified as trade
                     payables or operating  accruals as set forth on the face of
                     the  Closing  Balance  Sheet  (rather  than  in  any  notes
                     thereto);

              (b)    all written and oral  obligations  of the Seller  under the
                     Contracts  which   constitute   Purchased  Assets  and  all
                     obligations  under written and oral Contracts  entered into


                                      -8-


<PAGE>

                     by the Seller in the  Ordinary  Course of Business  between
                     the date of this  Agreement  and the Closing Date and which
                     do not violate any  covenant in this  Agreement,  but as to
                     any  obligation,  only to the  extent  that  payment is for
                     goods,  services or other  consideration  to another  party
                     that are  delivered,  performed or provided on or after the
                     Closing Date; and

              (c)    accrued  vacation  owing to employees of the Seller up to a
                     maximum of four weeks per employee.

provided,  however, that the Buyer shall not assume any obligation to the extent
the existence  thereof  violates or is in breach of any of the  representations,
warranties and covenants of the Seller or the Shareholder in this Agreement.

            3.2 Non-Assumption of Liabilities. Except only as expressly provided
in Section 3.1, the Buyer shall not be responsible  for, assume,  pay,  perform,
discharge, or accept any liabilities,  debts or obligations of the Seller of any
kind  whatsoever,  whether  actual,  contingent,   accrued,  known  or  unknown,
including,   without  limitation,   any  relating  to   interest-bearing   debt,
intercompany  indebtedness  owing from the Seller to the  Shareholder,  notes to
Affiliates  or other  related  Persons,  interest and  termination  penalties on
indebtedness, taxes, employee compensation,  severance, pension, profit-sharing,
vacation  in excess of four weeks per  employee,  health  insurance,  disability
insurance or other employee benefit plans and programs,  worker's  compensation,
breach or negligent  performance of any contract, or breach of warranty relating
thereto,  liabilities  resulting  from  breach of  contract,  torts  (including,
without  limitation,  product  liability  claims),  illegal  activity,  unlawful
employment or business practice,  infringement of intellectual  property rights,
claim for  environmental  liability  or  remediation  or any other  liability or
obligation whatsoever.  All such non-assumed liabilities,  debts and obligations
(collectively,  the "Excluded  Liabilities")  shall remain the responsibility of
the Seller which shall pay and discharge the same when and as due.

            3.3 Employee  Benefit  Plans.  The Buyer shall not assume,  honor or
accept any employee  benefit plan or stock option plan of the Seller,  including
but not  limited to any  employee  pension  benefit  plan  within the meaning of
Section 3(2) of ERISA.  Except for the  obligation  of the Buyer with respect to
accrued  vacation  set  forth in  Section  3.1(c)  and  except  for  liabilities
resulting from any failure by the Buyer to meet its  obligations  under Sections
7.8 or 7.13 of this  Agreement,  the  Seller  shall be  solely  responsible  for
satisfying all obligations  (whether arising under federal,  state or local law,
or pursuant to  contract)  which may arise or which may have arisen prior to the
Closing,  in  connection  with the  employment  by the  Seller  of the  Seller's
employees,  the creation,  funding or operation of any of the Seller's  employee
benefit plans that cover any of the Seller's employees,  or which may arise as a
result of the  transactions  described  in this  Agreement,  but  excluding  any
liabilities  incurred by the Seller as a result of the  Buyer's  failure to meet
its obligations under Sections 7.8 or 7.13 of this Agreement.

                                   ARTICLE IV

                         REPRESENTATIONS AND WARRANTIES

                          OF THE SELLER AND SHAREHOLDER


                                      -9-


<PAGE>

            In order to  induce  the  Buyer  and  Promega  to  enter  into  this
Agreement,  the Seller and the  Shareholder,  jointly  and  severally,  make the
following  representations  and  warranties  to the  Buyer  and  Promega  (which
representations  and warranties shall survive the Closing to the extent provided
in Section 10.4), each of which shall be deemed to be independently material and
relied upon by the Buyer and Promega,  regardless of any investigation  made by,
or  information  known to, the Buyer and  Promega.  Any matter  described on the
disclosure  schedules attached hereto and incorporated herein shall be set forth
with  reference to each separate  Section of this  Agreement to which the matter
relates.

            4.1 Ownership,  Organization and  Qualification.  The Seller and the
Shareholder are  corporations  duly  incorporated and in good standing under the
laws of the State of California  and the State of Delaware,  respectively,  have
not filed articles of dissolution and have a perpetual period of existence. Each
of the Seller and the  Shareholder  are  qualified  to  transact  business  as a
foreign  corporation  in  the  jurisdictions  where  it  is  required  to  be so
qualified,  except  where  such  failure to be  qualified  would not result in a
Material Adverse Effect.

            4.2 Authorization. The Seller and the Shareholder have all necessary
power and  authority  to enter into and  perform the  transactions  contemplated
hereby in accordance  with the terms and  conditions  hereof.  The execution and
delivery of this  Agreement,  and the  performance  by the Seller of each of its
obligations  contained herein, have been duly approved by the Board of Directors
of the Seller and the Shareholder,  and by the  Shareholder,  in its capacity as
sole shareholder of the Seller.  No other corporate  authorization by either the
Seller  or the  Shareholder  (including,  without  limitation,  approval  by the
Shareholder's  shareholders)  is required for the execution and delivery of this
Agreement or the  performance  by each of the Seller and the  Shareholder of its
obligations hereunder.

            4.3 Enforceability. Assuming the execution and delivery by the Buyer
and Promega have been duly  authorized,  this Agreement and all other agreements
of the Seller or the Shareholder  contemplated hereby are or, upon the execution
and delivery  thereof will be, the valid and binding  obligations  of the Seller
and the Shareholder,  respectively,  enforceable against them in accordance with
their terms.

            4.4  Conflicting  Obligations.  The  execution  and delivery of this
Agreement  does  not,  and the  consummation  of the  sale and  purchase  of the
Purchased  Assets will not: (a) conflict  with or violate any  provisions of the
certificate of incorporation or bylaws of each of the Seller or the Shareholder,
as  amended  and in  effect  on and as of the date  hereof  and on and as of the
Closing Date;  (b) conflict with or violate any  provisions of, or result in the
maturation or acceleration  of, any obligations  under any contract,  agreement,
instrument,  document,  lease, license, permit, indenture, or obligation, or any
law, statute,  ordinance, rule, regulation,  code, guideline, order, arbitration
award,  judgment or decree, to which the Seller or the Shareholder is subject or
to  which  the  Seller  or  the  Shareholder  is a  party;  or (c)  violate  any
restriction or limitation, or result in the termination or loss of any right (or
give any third Person the right to cause such  termination or loss), of any kind
to which the Seller or the Shareholder is bound, except, with respect to clauses
(b) and (c),  where  such  conflict,  violation  or loss  would not  result in a
Material Adverse Effect on the Business.


                                      -10-


<PAGE>

            4.5  Subsidiaries.  Except as set forth on Schedule  4.5, the Seller
owns no stock or other  securities of nor has any investment in any corporation,
joint  venture,  partnership  or other  business  enterprise.  The Seller has no
Subsidiaries.

            4.6 Title to Assets.  The Seller has good title to all of the Seller
Purchased  Assets and the  Shareholder  has good title to all of the Shareholder
Purchased Assets, in each case, free and clear of any Lien (other than Permitted
Liens).

            4.7 Third Party  Consents.  Except as set forth on Schedule  4.7, no
third  party  consents,  approvals  or  authorizations  are  necessary  for  the
execution and consummation of the transactions  contemplated hereby, nor are any
such  consents,  approvals  or  authorizations  required in order for any of the
Purchased Assets,  including without limitation,  the Contracts and the Permits,
to be assigned to the Buyer.

            4.8  Organizational  Documents.  Attached as Schedule  4.8 are true,
correct and complete  copies of the certificate of  incorporation  and bylaws of
the Seller and the Shareholder,  in each case as amended and in effect on and as
of the date hereof.

            4.9  Financial  Statements.  Attached as Schedule  4.9 are  complete
copies of the  unaudited  financial  statements  (including  December  31,  1998
balance  sheets and statements of earnings and cash flow) of the Seller for each
of its last three fiscal years ending December 31 through and including December
31, 1998 (the "Latest  Fiscal Year End"),  and a complete  copy of the unaudited
financial  statements  (including  balance  sheets and statement of earnings and
cash flow) of the Seller for the 2-month  period  ending  February 28, 1999 (the
"Latest Balance Sheet Date")  (collectively,  the "Financial  Statements").  The
Financial  Statements  have been prepared in accordance with GAAP maintained and
applied on a consistent  basis  throughout  the  indicated  periods,  and fairly
present  in all  material  respects  the  financial  condition  and  results  of
operation  of the Seller at the dates and for the  relevant  periods  indicated.
True and correct  copies  have been  delivered  to Buyer of all written  reports
submitted to the Seller or the Shareholder by the  Shareholder's  auditors since
January 1, 1994,  relating to the findings of audits or examination of the books
and  records of the  Seller and the  Shareholder;  provided,  that such  written
reports shall be redacted so that they shall include only those items related to
the Seller.


                                      -11-


<PAGE>

            4.10  Real  Property;  Leases.  The  Seller  does  not own any  real
property.  Schedule 4.10(a) sets forth a true and correct summary description of
all Real Estate leased or rented by the Seller.  The  description of each parcel
of Real Estate  describes such parcel fully and adequately.  To the Knowledge of
the Seller and the  Shareholder,  except as set forth on Schedule  4.10(a),  all
buildings,  structures  and other  improvements  on the Real  Estate are free of
defects that would result in loss to the Business in excess of $25,000.  The use
and operation of the Real Estate  conform to all  applicable  building,  zoning,
safety,  and  other  laws,  statutes,  ordinances,  rules,  regulations,  codes,
licenses,  material permits,  and all other restrictions and conditions,  except
where the failure to conform would not result in a Material  Adverse Effect.  To
the Knowledge of the Seller and the  Shareholder,  no portion of any of the Real
Estate is located in a flood  plain,  flood hazard area or  designated  wetlands
area.  Except as set forth on  Schedule  4.10(a),  neither  the  Seller  nor the
Shareholder  has received any written  notice of, and neither the Seller nor the
Shareholder has Knowledge of, any assessments  for public  improvements  against
the  Real  Estate  or any  written  order  by any  Governmental  Authority,  any
insurance  company  which has issued to the Seller or the  Shareholder  a policy
with respect to any parcel of Real Estate or any board of fire  underwriters  or
other body exercising similar functions that: (i) relates to material violations
of  building,  safety or fire  ordinances  or  regulations  which  have not been
remediated;  (ii) claims any material  defect or deficiency  with respect to any
parcel of Real  Estate  which has not been  remediated;  or (iii)  requests  the
performance  of any  repairs,  alterations  or other work to or in any parcel of
Real  Estate  or in the  streets  bounding  the  same  that  have  not yet  been
performed. Neither the Seller nor the Shareholder has made any arrangements with
any  Governmental  Authority  for the deferral of taxes or  assessments  for any
parcel of Real Estate. To the Knowledge of the Seller and the Shareholder, there
is  no  condemnation,   expropriation,  eminent  domain  or  similar  proceeding
affecting all or any portion of the Real Estate  pending or  threatened.  Except
where the Seller is lessee,  to the Knowledge of the Seller and the Shareholder,
there  are no  leases,  subleases,  licenses,  concessions  or other  agreements
(written or oral)  granting to any Person the right to use or occupy any portion
of each parcel of Real Estate.  Except as set forth on Schedule 4.10(a),  to the
Knowledge of the Seller and the Shareholder, there are no outstanding options or
rights of first  refusal to  purchase  any parcel of Real  Estate or any portion
thereof or interest therein.

            4.11  Personal  Property.  Schedule  4.11  sets  forth  all items of
personal  property  of the Seller  which have a book value or current  estimated
market value in excess of $25,000. Except for such personal property as has been
disposed of in the Ordinary  Course of Business  since the Latest  Balance Sheet
Date, the Seller owns all property  reflected on the Latest  Balance Sheet,  and
will own all  property  reflected  on the Closing  Balance  Sheet.  All tangible
personal  property of the Seller is located upon the Seller's  premises,  except
items in transit  or as set forth on  Schedule  4.11.  To the  Knowledge  of the
Seller and the  Shareholder,  all such property set forth on Schedule 4.11 is in
good condition and repair (normal wear and tear excepted).

            4.12 All Necessary  Assets.  The Purchased Assets  constitute all of
the material assets which are used in, and all of the assets which are necessary
for,  the conduct of the  Business,  as  presently  conducted  and  presently is
proposed to be conducted, subject to Section 1.5.

            4.13  Receivables.  All of the  Receivables (a) have arisen and will
arise solely from bona fide  transactions in the Ordinary Course of Business and
are not and will not be subject to  


                                      -12-


<PAGE>

counterclaim  or set-off and are not or will not be otherwise in dispute and (b)
are, and as of the Closing Date will, be good and collectible in full (less only
the  allowance  for  doubtful  accounts  receivable  as set forth on the  Latest
Balance Sheet), and will be collected (less only such allowance) within 120 days
following the Closing Date. Schedule 4.13 contains a true and correct aging list
of Receivables as of March 18, 1999, specifying the date of original invoice and
current payment status of each Receivable.

            4.14 Inventories.  The Inventories of the Seller have been valued at
the lower of cost or market.  The values at which  Inventories  are reflected on
the Financial Statements have been determined on a  first-in-first-out  basis in
accordance with GAAP consistently applied for all periods. The Inventories which
consist of  work-in-process  are being  completed  on schedule  and there are no
forfeitures, chargebacks or penalties which have been or will be incurred due to
the failure of the Seller to complete the  work-in-progress  in a timely manner.
None of the  Inventories  have been  consigned to others,  nor is any  inventory
consigned to the Seller.  All of the Inventories are located at San Luis Obispo,
California.

             4.15 Intellectual Property.

            (a) The Seller  owns or has the right to use  pursuant  to  license,
sublicense, agreement, or permission all Intellectual Property necessary for the
operation of the Businesses. Each item of Intellectual Property owned or used by
the Seller immediately prior to the Closing hereunder which constitute Purchased
Assets will be owned or available  for use by the Buyer on  identical  terms and
conditions immediately subsequent to the Closing hereunder.  To the Knowledge of
the Seller and the  Shareholder,  the Seller has taken all  necessary  action to
maintain and to protect each item of Intellectual  Property that it owns or uses
which constitute Purchased Assets, including, but not limited to, payment of any
and all maintenance fees and annuities.

            (b)  The   Seller  has  not   interfered   with,   infringed   upon,
misappropriated,  or otherwise come into conflict with any Intellectual Property
of any  Person  and,  except  as set  forth on  Schedule  4.15(b),  neither  the
Shareholder nor the Seller has received any charge, complaint, claim, demand, or
notice  alleging  any  such  interference,  infringement,  misappropriation,  or
violation of any Intellectual  Property of any other party,  including,  but not
limited  to, any claim that the Seller  must  license or refrain  from using any
Intellectual Property of any third party.

            (c) Schedule  4.15(c)  identifies each patent or registration  which
has been issued to the Seller with respect to any of its Intellectual  Property,
identifies each pending patent application or application for registration which
the  Seller  has made with  respect  to any of its  Intellectual  Property,  and
identifies each license,  agreement,  or other  permission  which the Seller has
granted to any third  party with  respect  to any of its  Intellectual  Property
(together  with any  exceptions).  The Seller has delivered to the Buyer correct
and complete copies of all such patents, registrations,  applications, licenses,
agreements,  and  permissions (as amended to date) and has made available to the
Buyer correct and complete copies of all other written documentation  evidencing
ownership and prosecution (if  applicable) of each such item.  Schedule  4.15(c)
identifies  each  trade  name or  unregistered  trademark  used by the Seller in
connection with any of its businesses. With respect to each item of Intellectual
Property required to be identified in Schedule 4.15(c):


                                      -13-


<PAGE>

                     (i) the Seller  possesses all right,  title and interest in
              and to the item,  free and clear of any  Lien,  license,  or other
              restriction;

                     (ii) the item is not subject to any outstanding injunction,
              judgment, order, decree, ruling, or charge;

                     (iii) no action, suit, proceeding,  hearing, investigation,
              claim, or demand is pending or, to the Knowledge of the Seller and
              the  Shareholder,  is threatened  which  challenges  the legality,
              validity, enforceability, use, or ownership of the item; and

                     (iv) the  Seller  has not  entered  into any  agreement  to
              indemnify   any   Person   for  or   against   any   interference,
              infringement, misappropriation, reexamination, opposition or other
              conflict with respect to the item.

             (d) Schedule  4.15(d)  identifies  each and every  material item of
Intellectual Property (excluding  commercially available computer software) that
any third party owns or licenses  and that the Seller uses  pursuant to license,
sublicense,  agreement,  or  permission.  The Seller has  delivered to the Buyer
correct and complete copies of all such licenses,  sublicenses,  agreements, and
permissions  (as  amended to date).  With  respect to each item of  Intellectual
Property  required to be  identified  in Schedule  4.15(d),  except as stated in
Schedule 4.15(d):

                     (i)  the  license,  sublicense,  agreement,  or  permission
              covering the item is legal, valid,  binding,  enforceable,  and in
              full force and effect;

                     (ii) the license, sublicense, agreement, or permission will
              continue to be legal,  valid,  binding,  enforceable,  and in full
              force and effect on identical terms following the  consummation of
              the transactions  contemplated  hereby  (including the assignments
              and assumptions referred to in Section 1.2 above);

                     (iii) to the  Knowledge of the Seller and the  Shareholder,
              no party to the license,  sublicense,  agreement, or permission is
              in breach or default,  and no event has occurred which with notice
              or lapse of time  would  constitute  a breach or default or permit
              termination, modification, or acceleration thereunder;

                     (iv) no party to the  license,  sublicense,  agreement,  or
              permission has repudiated any provision thereof;

                     (v) to the  Knowledge  of the Seller  and the  Shareholder,
              with  respect  to  each  sublicense,   the   representations   and
              warranties  set forth in  subsections  (i) through  (iv) above are
              true and correct with respect to the underlying license;

                     (vi) the underlying  item of  Intellectual  Property is not
              subject to any outstanding  injunction,  judgment,  order, decree,
              ruling or charge;

                     (vii) no action, suit, proceeding,  hearing, investigation,
              claim, or demand is pending or, to the Knowledge of the Seller and
              the  Shareholder,  is threatened  which  


                                      -14-


<PAGE>

              challenges  the  legality,  validity,  or  enforceability  of  the
              underlying item of Intellectual Property; and

                     (viii) the  Seller  has never  granted  any  sublicense  or
              similar right with respect to the license, sublicense,  agreement,
              or permission.

            (e) Except as set forth on Schedule 4.15(e),  neither the Seller nor
the Shareholder have any Knowledge of any products,  inventions or procedures of
competitors  which  reasonably  could  or  do  infringe  or  misappropriate  any
Intellectual Property of the Seller. The Seller has not given formal or informal
notice of infringement or sent a demand to "cease and desist" to any Person.

             4.16 Insurance.

            (a) General.  Schedule  4.16(a) lists and contains a description  of
each policy of  insurance  owned by the Seller  currently  in effect  (including
without  limitation,   policies  for  fire  and  casualty,  liability,  worker's
compensation,  business  interruption,  umbrella coverage,  products  liability,
medical, disability and other forms of insurance) specifying the insurer, amount
of coverage, type of insurance, policy number, deductible limits and any pending
claim  in  excess  of  $5,000,   whether  or  not  covered  by  insurance   (the
"Insurance").  True and complete  copies of each policy of  Insurance  have been
previously  delivered to Buyer.  The Insurance is in full force and effect,  all
premiums with respect thereto  covering all periods up to and including the date
hereof have been paid, and no notice of  cancellation  or  termination  has been
received by the Seller with respect to any such policy.  To the Knowledge of the
Seller and the Shareholder,  the Insurance is sufficient for compliance with all
requirements of law and with all agreements to which the Seller is a party.  The
Seller has not  received any notice from or on behalf of any  insurance  carrier
issuing  any  such  policy  that:   (i)  insurance   rates  will   hereafter  be
substantially  increased;  (ii) that there will  hereafter  be no renewal of any
such  policy;  or (iii) that  alteration  of any  personal  or real  property or
purchase  of  additional  equipment,  or  modification  of any  method  of doing
business, is required or suggested.

            (b)  Denials  of  Coverage.  The  Seller  has not been  refused  any
insurance  with  respect  to the  Seller's  assets  or  operations,  nor has the
Seller's  coverage been limited by any insurance carrier to which it has applied
for or with which it has carried insurance.

            (c)  Claims.  Schedule  4.16(c)  sets forth a list of and summary of
information  pertaining to, all claims (other than workers' compensation claims)
of property  damage and  personal  injury or death  against the Seller which are
currently  pending or were made during the  preceding  three (3) fiscal years or
the current fiscal year.  Except as set forth on Schedule  4.16(c),  all of such
claims are fully  satisfied or are being  defended by an  insurance  carrier and
involve no exposure to the Seller (other than deductibles).

            (d)  Self-Insurance.  Schedule 4.16(d) describes any  self-insurance
programs relating to the Business.

            4.17 Permits.  The Seller possesses all Permits (including,  without
limitation,  occupancy  permits for real estate and permits required pursuant to
Environmental  Law) as are necessary for the  


                                      -15-


<PAGE>

consummation  of the  transactions  contemplated  hereby or the  conduct  of its
business or operations,  except where the failure to hold such Permits would not
have a Material Adverse Effect on the Business.  Schedule 4.17 sets forth a list
of all Permits and true and complete copies of each written document  evidencing
or affecting any Permits have been previously delivered to the Buyer. The Seller
is in compliance with the terms and conditions of all Permits, except where such
noncompliance would not result in a Material Adverse Effect.

             4.18 Material Contract. Schedule 4.18 lists the following contracts
and other agreements to which the Seller is a party:

             (a) Leases. All leases of real or personal property,  excluding the
leases described in Schedule 4.10(a) hereof;

             (b)  Purchase  and Sale  Orders.  All written and oral  agreements,
including  purchase  orders,  relating  to the  purchase  or sale  of  products,
services or supplies by the Seller other than (i) any such agreements which have
been completely performed and (ii) individual purchase or sales orders issued in
the  Ordinary  Course  of  Business  for  amounts  in each case not in excess of
$10,000 individually;

             (c) Certain  Agreements.  All of the following  described  types of
agreements or documents:  (i)  distributorship,  sales representative or similar
agreements;  (ii)  license,  royalty or  similar  agreements;  (iii)  service or
maintenance;  (iv) protective services or security;  and (v) commission or other
contingent agreements pursuant to which the Seller's obligation to make payments
is in excess of $10,000 per year,  or pursuant to which the Seller's  obligation
to make contingent payments is dependent upon sales,  revenues,  income, success
or other performance standard;

             (d)  Other  Financial  Obligations.  All  other  written  and  oral
agreements or commitment  which requires the Seller to pay or expend,  after the
Closing,  more than $10,000 in the aggregate of all such instances with the same
or related parties;

             (e)  Capital   Expenditures.   All  outstanding  written  and  oral
commitments  by the Seller to make a capital  expenditure,  capital  addition or
capital improvement in excess of $10,000;

             (f) Employment Contracts.  All written and oral employment,  bonus,
incentive  compensation,  profit sharing,  stock option,  salary-continuation or
other fringe benefit agreements, other than those disclosed in Schedule 4.25(a),
currently in effect or to become  effective,  or under which any amounts  remain
unpaid,  on the date of this Agreement or to become  payable or effective  after
the date of this Agreement;

             (g)  Non-Compete  Covenants.  All written and oral covenants not to
compete, non-solicitation covenants and non-disclosure covenants in favor of the
Seller, or binding upon or against the Seller;

             (h) Discounts. All agreements, arrangements or programs pursuant to
which the Seller has offered,  promised or made  available to its  customers any
volume discount, rebate, credit or allowance; and


                                      -16-


<PAGE>

            (i) Non-Ordinary Course Agreements. All other contracts,  agreements
and  arrangements  binding  upon the Seller  and which was made or entered  into
either other than in the Ordinary Course of Business or the performance of which
involves consideration in excess of $10,000.

The  Seller  has  delivered  to the Buyer a correct  and  complete  copy of each
written  agreement  listed on  Schedule  4.18 (as amended to date) and a written
summary  setting forth the material  terms and conditions of each oral agreement
which involve amounts in excess of $10,000 as referred to in Schedule 4.18. With
respect to each such  agreement:  (i) the  agreement is legal,  valid,  binding,
enforceable,  except  as  enforceability  may  be  limited  by  (A)  bankruptcy,
insolvency,  reorganization,  moratorium  or similar  law  affecting  creditors'
rights generally or (B) general  principles of equity,  whether  considered in a
proceeding in equity or at law, and in full force and effect;  and (ii) no party
is in breach or default, and no event has occurred which with notice or lapse of
time would constitute a breach or default, or permit  termination,  modification
or  acceleration  under the  agreement;  and (iii) no party has  repudiated  any
provision of the agreement.

            4.19  Litigation.  Except as set forth on Schedule  4.19 or Schedule
4.21(a),  there is not now,  and there has not been  within  the last  three (3)
years, any litigation,  claim,  proceeding or investigation  pending, or, to the
Seller's or the Shareholder's  Knowledge,  threatened against or relating to the
Seller,  its  properties  or  the  Business,  or  the  ability  to  perform  its
obligations under this Agreement. Schedule 4.19 sets forth, with respect to each
item  described  thereon,  the name or  title  of the  action  (and  parties  or
potential parties thereto),  a description of the nature of the action or claim,
and an  estimate  of the  maximum  liability  of the  Seller  in the event of an
adverse result.  Except as so described,  neither the Seller nor the Shareholder
have Knowledge of any facts or circumstances  which reasonably could be expected
to ripen into  litigation,  proceeding or  investigation  that would result in a
Material  Adverse  Effect.  Except as  described on Schedule  4.19,  there is no
outstanding order, decree or stipulation issued by any Governmental Authority to
which  the  Seller is a party or  subject  and which  adversely  affects  or may
adversely affect its properties, business or prospects.

            4.20 Compliance  With Law. Except as set forth on Schedule  4.21(a),
the  conduct  of the  Business  does not  violate,  nor is the Seller in default
under, any law, statute,  ordinance,  rule, regulation,  code, license,  permit,
guideline,  order,  arbitration  award,  judgment or decree,  and Buyer will not
after the Closing  incur any  Liability  or  obligation  as a result of any such
violation or default  existing at the Closing or arising or accruing  thereafter
but based upon conditions  existing at the Closing,  except where such violation
or default would not have a Material  Adverse Effect on the Business.  Except as
set forth on Schedule 4.20, no material  expenditures are anticipated  which are
necessary or appropriate for the continuation of the Business in compliance with
any such law, statute,  rule,  regulation,  code, license,  permit,  guidelines,
order, arbitration award, judgment or decree.

             4.21 Environmental Matters.

             (a)  Environmental  Compliance.  Except  as set  forth in  Schedule
4.21(a),   (i)  the  Seller  is  


                                      -17-


<PAGE>

in  material  compliance  with  all  applicable  Environmental  Laws  and to the
Knowledge of the Seller and the Shareholder,  the Leased Property is in material
compliance with all applicable Environmental Laws; (ii) the Seller has furnished
or made available to the Buyer and Promega all communications (either written or
oral) received by the Seller or the Shareholder from a Governmental Authority or
other  Person  which  alleges  that the Seller,  the  Shareholder  or the Leased
Property is not in material  compliance with any applicable  Environmental  Law;
(iii) to the Knowledge of the Seller and the Shareholder, neither the Seller nor
the Shareholder is under  investigation  by any  Governmental  Authority for the
failure to comply in all material  respects  with any  Environmental  Law;  (iv)
neither  the Seller nor the  Shareholder  is  required  to take on behalf of the
Business  or at the  Real  Estate,  any  Remedial  Action  by  any  Governmental
Authority or  Environmental  Law; and (v) to the Knowledge of the Seller and the
Shareholder,  neither the Seller nor the  Shareholder  has made any  statements,
warranties,  or representations  in any documents  submitted to any Governmental
Authority  or  submittal   created   pursuant  to  an   obligation   imposed  by
Environmental  Law containing any untrue  statement of material fact or omitting
any statement of material fact which render the  statements  made  misleading in
connection with any Environmental Law.

            (b)  Environmental  Permits.  The  Seller and the  Shareholder  have
obtained all Environmental  Permits necessary for the Seller's operations on the
Leased Property, and all such Environmental Permits are in good standing.

            (c) Pending Litigation.  Except as set forth in Schedule 4.21(c), to
the Knowledge of the Seller and the Shareholder, there is no Environmental Claim
pending or threatened  against the Seller or the  Shareholder in connection with
the Leased  Property  or the  Business,  operations  or  actions of the  Seller.
Neither  the Seller nor the  Shareholder  has  received  any notice of any past,
present or future event, condition, circumstance,  activity, practice, incident,
action  or plan  which  may give  rise to any  Environmental  Claim  based on or
related to the Leased Property.

            (d) Disposal Practices.  Except as set forth in Schedule 4.21(d), to
the  Knowledge  of the Seller  and the  Shareholder,  neither  the  Seller,  the
Shareholder  nor any other Person has arranged  for the  disposal,  treatment or
recycling  of, or  transported  for  disposal,  treatment  or  recycling  of any
Environmental  Material,  including,  but not limited to, any  Hazardous  Waste,
PCB-containing  Material,  petroleum  substance  (including  crude  oil  or  any
fraction  thereof),  or petroleum  product from the Leased Property to any other
location which has been identified on the National Priority List (NPL),  CERCLIS
or state  equivalent  lists. To the knowledge of the Seller and the Shareholder,
no  Environmental  Materials  have, in a manner that violates any  Environmental
Laws, been transported from the Leased Property for purposes of disposal.

            4.22  Contingent  and  Undisclosed  Liabilities.  The  Seller has no
Liabilities,  whether  such  Liabilities  are now  known  or  unknown,  fixed or
contingent,  of any nature  whatsoever,  except:  (i) those fully  reflected  or
reserved  against on the face of the Latest  Balance  Sheet  (rather than in any
notes  thereto);  (ii) those fully disclosed in this Agreement and the Schedules
hereto; or (iii) Liabilities which do not result in a Material Adverse Effect.


                                      -18-


<PAGE>

             4.23 Tax Matters.

            (a) The Seller has filed all Tax  Returns  that it was  required  to
file. All such Tax Returns were correct and complete in all respects.  All Taxes
owed by the Seller  (whether or not shown on any Tax Return) have been paid. The
Seller is not currently the beneficiary of any extension of time within which to
file  any  Tax  Return.  No  claim  has  ever  been  made by an  authority  in a
jurisdiction  where the Seller  does not file Tax  Returns  that it is or may be
subject  to  taxation  by that  jurisdiction.  There  are no Liens on any of the
assets of the Seller  that arose in  connection  with any  failure  (or  alleged
failure) to pay any Tax.

            (b) The Seller has withheld and paid all Taxes required to have been
withheld and paid in  connection  with  amounts  paid or owing to any  employee,
creditor, stockholder, or other third party.

             4.24 Employees; Labor Matters.

             (a) Schedule 4.24(a) lists each of the following:

              (i)    (A) all officers and directors of the Seller; (B) the names
                     and current  annual  salary rates (and bonus,  incentive or
                     commission  arrangements)  of all  full-time  and part-time
                     employees  and agents of the Seller;  (C) all loans made by
                     the Seller to its  employees  and a statement  of the terms
                     thereof;  and (D) a list of all of the  Seller's  employees
                     who are  currently  laid-off or on parental,  disability or
                     other leave; and

              (ii)   All employees who are expected,  as of the Closing Date, to
                     have earned but unused vacation and other personal days (or
                     earned but unpaid  vacation pay in lieu thereof),  together
                     with an estimate of the dollar amount thereof.

             (b)  The  Seller  is  not a  party  to  any  collective  bargaining
agreement  or  bound  to any  other  agreement  with a labor  union.  The  labor
relations of the Seller are  satisfactory  in that there has not been within the
preceding  three (3) fiscal years of the Seller and the current fiscal year, nor
is there currently,  any strike, walkout or work stoppage;  nor, to the Seller's
and the  Shareholder's  Knowledge,  is any such action  threatened.  Neither the
Seller nor the  Shareholder  has been  notified of any  proceedings  pending for
certification or  representation  before the National Labor Relations Board nor,
to the  Seller's  and the  Shareholder's  Knowledge,  has there been any attempt
within  the  preceding  three (3) fiscal  years or the  current  fiscal  year to
organize the employees of the Seller into a collective  bargaining  unit. To the
Knowledge of the Seller and the Shareholder,  there is no investigation pending,
nor is there any uncorrected or unresolved citation, complaint or charge issued,
by any agency  responsible for administering or enforcing laws relating to labor
relations,  employee safety or health, fair labor standards and equal employment
opportunity nor, to the Knowledge of the Seller and the Shareholder, is any such
proceeding threatened.


                                      -19-


<PAGE>

             4.25 Employee Benefit Plans.

            (a) General.  Schedule  4.25(a) sets forth a true and complete  list
and brief  description  of each "employee  pension  benefit plan" (as defined in
Section 3(2) of ERISA),  each  "employee  welfare  benefit  plan" (as defined in
Section 3(1) of ERISA) and each and every other employee benefit plan maintained
or  contributed  to, or  required  to be  contributed  to, by the Seller for the
benefit of any officers or employees,  current or former, active or inactive, of
the  Business,  whether on an active or frozen  basis (all the  foregoing  being
herein  called  "Benefit  Plans").  The Seller  does not have any formal plan or
commitment,  whether  legally  binding or not, to modify or change any  existing
Benefit Plan that would  affect any  employee or former  employee of the Seller.
True,  complete  and  correct  copies  of the  following  have  been  previously
delivered to the Buyer: (i) each Benefit Plan, including any amendments thereto;
(ii) the most recent Form 5500 or Form 5500-C filed with the IRS with respect to
each  Benefit  Plan (if any such  report was  required),  (iii) the most  recent
summary  plan  description  together  with each  subsequent  summary of material
modifications  required under ERISA with respect to each Benefit Plan; (iv) each
trust agreement or other funding arrangement relating to each Benefit Plan which
is an  employee  pension  benefit  plan as  defined  in  Section  3(2) of  ERISA
(hereinafter  "Pension  Plan");  and (v) all currently  effective IRS rulings or
determination letters relating to each Pension Plan.

            (b) PBGC.  No Pension Plan is subject to Title IV of ERISA and there
are no facts which might give rise to any liability of the Seller under Title IV
of ERISA or which could  reasonably be anticipated to result in any claims being
made against the Seller by the Pension Benefit Guaranty Corporation with respect
to any Pension Plan. For purposes of the preceding  sentence and Section 4.25(e)
hereof,  the term  "Seller"  shall also include any entity which is under common
control or affiliated with the Seller,  within the meaning of Section 4001(b)(1)
of ERISA, and the rules and regulations  promulgated  thereunder and/or Sections
414(b),  (c), (m) or (o) of the Code, and the rules and regulations  promulgated
thereunder.

            (c) Post-Retirement  Benefits.  Except as disclosed on Schedule 4.18
or Schedule  4.25(a),  no Benefit  Plan  provides  benefits,  including  without
limitation,  death,  disability,  or medical benefits  (whether or not insured),
with  respect  to current  or former  employees  of the  Business  beyond  their
retirement or other  termination of service other than (i) coverage  mandated by
applicable law, or (ii) death benefits or retirement  benefits under any Pension
Plan.

            (d) COBRA.  Each "group  health plan" (within the meaning of Section
5000(b)(1)  of the Code)  maintained  by the Seller  that  covers or has covered
employees of the Business,  as of the first day of each such group health plan's
first plan year  beginning on or after July 1, 1986,  has been  administered  in
compliance with the continuation  coverage  requirements  initially enacted as a
part of the Consolidated Omnibus Budget Reconciliation Act of 1985 ("COBRA") and
as formerly provided under Section 162(k) of the Code and as currently  provided
under  Sections  601 through 609 of ERISA and Section  4980B of the Code and any
regulations  promulgated or proposed under any of those Code or ERISA  sections,
except where a failure to  administer  any such group health plan in  compliance
with such laws and regulations would not have a Material Adverse Effect.

            (e) Multiemployer  Plans. At no time has the Seller been required to
contribute  to, or  incurred  any  withdrawal  liability  (within the meaning of
Section  4201 of ERISA) to any  Benefit  


                                      -20-


<PAGE>

Plan which is a  multiemployer  plan as defined in Section 3(37) of ERISA and no
event has  occurred  that  could  result in any  liability  of the Seller to any
multiemployer plan.

            (f) Foreign Employees.  No current officers or employees,  active or
inactive,  of the  Business  regularly  work at a  location  outside  the United
States.

            (g)  Family and  Medical  Leave.  Except as  disclosed  on  Schedule
4.25(g), on the date hereof, no employees of the Seller are inactive or are on a
leave of  absence  covered by the Family  and  Medical  Leave Act of 1993,  P.L.
103-3.

            4.26  Products  Liability.  To the  Knowledge  of the Seller and the
Shareholder,  there exists no defect in the design or  manufacture of any of the
Seller's products and there is no pending or threatened action,  suit,  inquiry,
proceeding  or  investigation  by or before any Person  relating  to any product
alleged to have been manufactured,  distributed or sold by the Seller to others,
and alleged to have been defective or improperly  designed or manufactured or in
breach of any express or implied product warranty ("Products Liability").  There
exists  no  pending  or, to the  Knowledge  of the  Seller  or the  Shareholder,
threatened,  Products  Liability  claims. To the Knowledge of the Seller and the
Shareholder,  there  is no  valid  basis  for any such  suit,  inquiry,  action,
proceeding,  investigation or claim. The Seller does not have any Liability (and
there is no basis for any present or future action, suit,  proceeding,  hearing,
investigation,  charge,  complaint,  claim, or demand against any of them giving
rise to any Liability) arising out of any injury to individuals or property as a
result of the ownership,  possession, or use of any product manufactured,  sold,
leased or delivered by the Seller.  The Seller is insured,  and has been insured
continuously for the past five years against product liabilities,  in accordance
with  the  insurance  policies  identified  on  Schedule  4.16(a)  (including  a
statement  of the  name of the  insurer,  the type of  policy,  the  amounts  of
coverage and the applicable deductible limits).

            4.27 Product Warranty. All product warranties given by the Seller in
connection  with the  Business:  (a)  limit the  remedy  available  to  Seller's
customers to the replacement of the warranted goods by Seller, or alternatively,
a refund of the sales price of such goods to customer;  (b)  expressly  disallow
claims for incidental or consequential  damages;  and (c) expressly disclaim all
other  warranties  not expressly  stated  therein,  whether  express or implied,
including warranties of merchantability, fitness for a particular purpose.

            4.28 Events  Subsequent  to Latest  Fiscal  Year End.  Except as set
forth on  Schedule  4.28,  since the  Latest  Fiscal  Year End,  the  Seller has
operated in the Ordinary  Course of Business and there has not been any Material
Adverse  Effect.  Without  limiting the generality of the foregoing,  since that
date, except as set forth on Schedule 4.28:

            (a) The Seller has not sold, leased, transferred, or assigned any of
its  assets,  tangible  or  intangible,  other  than sales of  Inventory  in the
Ordinary  Course of  Business  or which  would not result in a Material  Adverse
Effect on the Business;

            (b) The Seller has not entered into any agreement,  contract,  lease
or license (or series of related  agreements,  contracts,  leases, and licenses)
either involving more than $10,000 or outside the Ordinary Course of Business;


                                      -21-


<PAGE>

            (c) No party  (including  the Seller) has  accelerated,  terminated,
modified, or cancelled any agreement,  contract, lease, or license (or series of
related agreements,  contracts, leases, or licenses) involving more than $10,000
individually to which the Seller is a party or by which it is bound;

            (d) The Seller has not made any  capital  expenditure  (or series of
related capital expenditures) either involving more than $25,000 individually or
outside the Ordinary Course of Business;

            (e) The Seller has not made any capital  investment in, any loan to,
or any  acquisition  of the securities or assets of, any other Person (or series
of related capital  investments,  loans, and acquisitions) either involving more
than $25,000 individually or outside the Ordinary Course of Business;

            (f) The Seller has not issued any note, bond, or other debt security
or created, incurred, assumed, or guaranteed any indebtedness for borrowed money
or capitalized lease obligation;

            (g) The Seller has not delayed or postponed  the payment of accounts
payable and other Liabilities outside the Ordinary Course of Business;

            (h) The Seller has not cancelled,  compromised,  waived, or released
any right or claim (or series of related rights and claims);

            (i) The Seller has not  granted  any  license or  sublicense  of any
rights under or with respect to any of its Intellectual Property;

            (j) There has been no change made or authorized  in the  certificate
of incorporation or bylaws of the Seller;

            (k) The Seller has not issued, sold, or otherwise disposed of any of
its capital stock, or granted any options, warrants, or other rights to purchase
or obtain (including upon conversion,  exchange, or exercise) any of its capital
stock;

            (l) The Seller has not declared,  set aside, or paid any dividend or
made any  distribution  with respect to its capital stock (whether in cash or in
kind) or redeemed, purchased, or otherwise acquired any of its capital stock;

            (m) The Seller has not experienced any damage,  destruction, or loss
(whether  or not  covered by  insurance)  to its  property,  other than  damage,
destruction  or loss  that did not,  individually  or in the  aggregate,  have a
Material Adverse Effect;

            (n) The Seller  has not made any loan to, or entered  into any other
transaction with, any of its directors,  officers, and employees, except for the
payment of compensation in the Ordinary Course of Business;


                                      -22-


<PAGE>

            (o) The Seller  has not  entered  into any  employment  contract  or
collective bargaining  agreement,  written or oral, or modified the terms of any
existing such contract or agreement outside the Ordinary Course of Business;

            (p) The Seller has not granted any increase in the base compensation
of any of its directors,  officers, and employees outside the Ordinary Course of
Business;

            (q) The Seller has not adopted, amended, modified, or terminated any
bonus,  profit-sharing,  incentive,  severance,  or  other  plan,  contract,  or
commitment for the benefit of any of its directors,  officers, and employees (or
taken any such action with respect to any other Employee  Benefit  Plan),  other
than as necessary to comply with applicable law (including Section 401(a) of the
Code) and other than in the Ordinary Course of Business;

            (r) The Seller has not made or  pledged  to make any  charitable  or
other capital contribution outside the Ordinary Course of Business;

            (s) Neither  the Seller nor the  Shareholder  has  entered  into any
agreement or arrangement for the sale of the Business or any part thereof or for
the purchase of another business, whether by merger, consolidation,  exchange of
capital stock or otherwise (other than with respect to this Agreement);

            (t) The Seller has not changed or modified its accounting methods or
practice;

            (u) The Seller has not settled, or agreed to settle, any litigation,
arbitration or other proceeding; and

            (v) The Seller has not committed to any of the foregoing.

            4.29  Customers and  Suppliers.  Schedule 4.29 lists,  in descending
order,  those customers of the Seller accounting for at least 5% of annual sales
volume in the  Seller's  most  recently  completed  fiscal  year and the top ten
suppliers of raw materials or supplies accounting for the largest annual expense
to the  Seller.  The Seller  has  received  no notice,  nor do the Seller or the
Shareholder  have  any  Knowledge,  that  (a) any  customer  of the  Seller  who
accounted  for  five  percent  (5%) or more of the  Seller's  sales  during  its
immediately  preceding  fiscal  year or (b) any  supplier to the Seller (if such
supplier could not be replaced by the Seller with no material  adverse effect to
it), has terminated or will terminate business relations with the Seller.

            4.30  Brokerage.  Except as described on Schedule 4.30,  neither the
Seller nor the Shareholder has incurred, or made commitments for, any brokerage,
finders' or similar fee in connection with the transactions contemplated by this
Agreement.

            4.31 Affiliate  Transactions.  Except as described on Schedule 4.31,
the Seller:  (a) has not had any financial  transactions or arrangements  (other
than  payment  of  regular  salary to  Affiliates  who are  employees)  with any
Affiliate  since the Latest  Fiscal Year End, and (b) does not have and will not
have any  present  or  future  obligation  to  enter  into  any  transaction  or
arrangement  with any  Affiliate.  Except as  described  on  Schedule  4.31,  no
Affiliate owns,  directly or indirectly,  or is a 


                                      -24-


<PAGE>

director,  member,  officer or  employee  of, or  consultant  to,  any  business
organization  which is a competitor,  supplier,  or customer of the Seller,  nor
does any Affiliate own any assets or properties which are used in the Business.

            4.32  Guaranties.  The Seller is not a guarantor or otherwise liable
for any Liability  (including,  without  limitation,  indebtedness) of any other
Person.

            4.33  Investment.  The Seller (i) understands  that the Note has not
been, and will not be,  registered  under the Securities Act, or under any state
securities  laws,  and are being  offered and sold in reliance  upon federal and
state exemptions for  transactions  not involving any public  offering,  (ii) is
acquiring the Note solely for its own account for investment  purposes,  and not
with a view to the distribution thereof (except to the Shareholder),  (iii) is a
sophisticated  investor with  knowledge and experience in business and financial
matters, (iv) has received certain information  concerning the Buyer and has had
the opportunity to obtain additional information as desired in order to evaluate
the merits and the risks  inherent in holding the Note,  (v) is able to bear the
economic risk and lack of liquidity  inherent in holding the Note and (vi) is an
Accredited Investor.

            4.34  Commission  Filings.   The  Shareholder  has  filed  with  the
Commission  all reports,  registration  statements,  proxy  statements and other
filings  (including  all notes,  exhibits and  schedules  thereto and  documents
incorporated by reference  therein) required to be filed by the Shareholder with
the Commission since December 31, 1997 (such reports,  registration,  statements
and  other  filings,   together  with  any  amendments  thereto,  are  sometimes
collectively  referred to as the  "Commission  Filings").  The  Shareholder  has
delivered to the Buyer true and complete copies of all Commission Filings within
the past year. The Commission Filings and any forms, reports and other documents
filed by the  Shareholder  with the Commission  after the date of this Agreement
(a) were or will be prepared in all  material  respects in  accordance  with the
requirements of the Securities Act and the Exchange Act, as the case may be, and
(b) at the time they were or will be filed with the Commission,  did not contain
any  untrue  statement  of a  material  fact or omit to  state a  material  fact
required to be stated therein or necessary to make the statements  made therein,
in light of the  circumstances  under which they were made, not misleading.  The
Seller has not ever been  required  to file any form,  report or other  document
with the Commission.  Each of the audited consolidated  financial statements and
unaudited  interim  financial   statements   (including  any  related  notes  or
schedules)  included in the Commission  Filings was prepared in accordance  with
GAAP applied on a consistent basis except as may be indicated  therein or in the
notes or schedules  thereto,  and fairly presents the financial  position of the
Shareholder  and its  consolidated  subsidiaries as at the dates thereof and the
results of their  operations,  cash flows,  changes in  financial  position  and
changes in stockholders' equity for the periods then ended.

            4.35 Amersham  Termination.  Neither the Seller nor the  Shareholder
has received any notices or other  communication  from  Amersham  International,
p.l.c.  challenging  the  validity of the Seller's  termination  of that certain
agreement  dated August 16, 1995 between the Seller and Amersham  International,
p.l.c.

            4.36   Representations   and  Warranties   True  and  Correct.   The
representations  and warranties  contained herein, and, subject to the following
sentence,  all other  documents,  certifications,  materials  and  statements or
information  given to the Buyer by or on behalf of the 


                                      -24-


<PAGE>

Seller or Shareholder or disclosed in this Agreement,  do not include any untrue
statement  of a material  fact or omit to state a material  fact  required to be
stated herein or therein in order to make the statements  herein or therein,  in
light  of  the  circumstances   under  which  they  are  made,  not  misleading.
Notwithstanding the foregoing,  neither the Seller nor the Shareholder makes any
representation,   warranty  or  other   assurance  that  any  of  the  financial
information,  financial  estimates,  forecasts or projections  contained in that
certain Confidential  Memorandum,  delivered to Promega via facsimile on October
28, 1998 and relating to the Business, will be realized.

                                    ARTICLE V

                          REPRESENTATIONS OF THE BUYER

            In order to induce the Seller and the Shareholder to enter into this
Agreement,  the Buyer makes the following  representations and warranties to the
Seller and the Shareholder (which  representations  and warranties shall survive
the  Closing to the extent  provided  in Section  11.4),  each of which shall be
deemed to be  independently  material  and  relied  upon by the  Seller  and the
Shareholder,  regardless of any investigation  made by, or information known to,
the Seller and the Shareholder.

            5.1 Ownership, Organization and Qualification. Each of the Buyer and
Promega is a corporation  duly  incorporated and validly existing under the laws
of the State of Wisconsin,  has filed with the appropriate state agency the most
recent  annual  report  required  to be filed by it, has not filed  articles  of
dissolution  and has a  perpetual  period  of  existence.  Each of the Buyer and
Promega are  qualified  to transact  business  as a foreign  corporation  in the
jurisdictions where it is required to be so qualified,  except where the failure
to be qualified would not result in a material adverse effect on the operations,
prospects or condition (financial or otherwise) on Promega.

            5.2  Authorization.  Each of the Buyer and Promega  (with respect to
its  obligations  under Section  12.2) has all necessary  power and authority to
enter into and perform the transactions  contemplated  hereby in accordance with
the terms and conditions  hereof.  The execution and delivery of this Agreement,
and the  performance by each of the Buyer and Promega of each of its obligations
contained herein,  have been duly approved by the Buyer's and Promega's Board of
Directors.  No other corporate authorization of the Buyer or Promega is required
for the execution and delivery of this  Agreement or the  performance by them of
their obligations hereunder.

            5.3  Enforceability.  Assuming  the  execution  and  delivery by the
Seller and the  Shareholder  have been duly  authorized,  this Agreement and all
other agreements of the Buyer and Promega  contemplated hereby and, with respect
to Promega,  its  obligations  under  Section  12.2,  are or, upon the execution
thereof,  will be the valid  and  binding  obligations  of each of the Buyer and
Promega  enforceable  against each of the Buyer and Promega,  as applicable,  in
accordance with their terms.

            5.4  Conflicting  Obligations.  The  execution  and delivery of this
Agreement do not, and the consummation of the sale and purchase of the Purchased
Assets will not: (a) conflict with or violate any  provisions of the articles of
incorporation of each of the Buyer and Promega; 


                                      -25-


<PAGE>

            (b)  conflict  with or violate any  provisions  of, or result in the
maturation or acceleration  of, any obligations  under any contract,  agreement,
instrument,  document,  lease, license, permit, indenture, or obligation, or any
law, statute,  ordinance, rule, regulation,  code, guideline, order, arbitration
award,  judgment or decree, to which the Buyer or Promega is subject to or which
the Buyer or Promega is a party;  or (c) conflict  with,  result in a breach of,
constitute a default under,  result in the  acceleration of, create in any party
the right to accelerate,  terminate,  modify,  or cancel,  or require any notice
under any agreement,  contract, lease, license,  instrument or other arrangement
to which the Buyer or Promega is a party or by which it is bound or to which any
of the assets of the Buyer or Promega is subject.

            5.5  Litigation.  There  is  no  litigation,  claim,  proceeding  or
investigation  pending,  or to the Buyer's  Knowledge,  threatened,  against the
Buyer or Promega and  relating  to their  ability to perform  their  obligations
under this Agreement.

            5.6 Brokerage.  Neither the Buyer nor Promega has incurred,  or made
commitment  for, any brokerage,  finders' or similar fee in connection  with the
transactions contemplated by this Agreement.

                                   ARTICLE VI

                   COVENANTS OF THE SELLER AND THE SHAREHOLDER

            The Seller and the Shareholder,  jointly and severally, covenant and
agree with the Buyer as follows:

            6.1  Access.  From the date  hereof  and  until the  earlier  of (i)
termination of this Agreement pursuant to Article XII and (ii) the Closing Date,
the Buyer and its authorized  officers,  agents and  representatives  shall have
full  access  (upon  reasonable  prior  notice)  to  all  properties,   Records,
Contracts, Tax Returns,  management letters, work papers of outside auditors and
other documents of the Seller.  The Seller and the  Shareholder  shall cooperate
with the Buyer by using reasonable efforts to arrange meetings among the Seller,
the Buyer and the Seller's  customers  and suppliers to meet with and respond to
all questions posed by the Buyer  concerning the Seller and promptly  responding
to, and causing the Seller's and the Shareholder's  outside  auditors,  officers
and  employees  promptly  to  respond  to,  all  questions  posed  by the  Buyer
concerning  the Seller,  the Business,  the Purchased  Assets,  or the condition
(financial or otherwise) or prospects of the Seller.

            6.2  Operation  of  Business.  From the date  hereof  and  until the
Closing Date, without the express prior written consent of the Buyer, the Seller
shall not engage in any practice,  take any action or enter into any transaction
outside the Ordinary Course of Business.  Without limiting the generality of the
foregoing, the Seller shall not:

            (a) issue, sell or otherwise dispose of any of its capital stock, or
grant any  options,  warrants or other  rights to purchase or obtain  (including
upon conversion, exchange or exercise) any of its capital stock;


                                      -26-


<PAGE>

            (b) declare,  set aside or pay any dividend or make any distribution
with  respect  to its  capital  stock  (whether  in cash or in kind) or  redeem,
purchase or otherwise acquire any of its capital stock;

            (c)  without  the  prior  approval  of the  Seller,  enter  into any
agreement with Affiliates or any other Person (other than in the Ordinary Course
of Business)  that cannot be  terminated  upon thirty (30) days' notice  without
liability to the Seller and without payment of any  cancellation fee or penalty;
or

            (d) otherwise engage in any practice,  take any action or enter into
any transaction of the sort described in Section 4.28.

            6.3  Preservation  of  Business.  From the date hereof and until the
Closing  Date,  the  Seller  and the  Shareholder  shall  carry on the  Business
substantially  in the  Ordinary  Course of Business  and shall use  commercially
reasonable   efforts  to  keep  the  Business  intact,   including  its  present
relationships with employees, suppliers and customers and others having business
relations  with it.  The Seller  shall use  commercially  reasonable  efforts to
maintain at all times in inventory quantities of raw materials,  finished goods,
spare parts and other  supplies and  materials  sufficient to allow the Buyer to
continue to operate the Business, after the Closing Date, free from any shortage
of such items.

            6.4 Insurance and Maintenance of Property.  From the date hereof and
until the Closing Date,  the Seller shall cause all property  owned or leased by
it to be insured  against all  ordinary  insurable  risks and shall  maintain in
effect all the  Insurance,  and shall  operate,  maintain  and repair all of its
property in a manner consistent with past practice.

            6.5 Compliance with Laws. From the date hereof and until the Closing
Date, the Seller shall comply with all applicable  laws,  statutes,  ordinances,
rules,  regulations,  guidelines,  orders,  arbitration  awards,  judgments  and
decrees applicable to, or binding upon, the Seller or the Business, except where
such noncompliance would not have a Material Adverse Effect.

            6.6 Supplemental Disclosure. On the Closing Date, the Seller and the
Shareholder  shall  inform the Buyer in writing  of all  information,  events or
actions  which,  if this  Agreement  were signed on the Closing  Date,  would be
required to be disclosed on the  Schedules in order to make the Seller's and the
Shareholder's  representations  and  warranties  contained  herein  true and not
misleading.  The delivery  thereof by the Seller and the  Shareholder  shall not
absolve  the  Seller  or  the  Shareholder  from  liability  for  breach  of any
representation or warranty which was untrue when made.

            6.7 Fulfill  Conditions.  The Seller and the  Shareholder  shall use
their best  efforts to cause to be  fulfilled on or prior to the Closing each of
the conditions set forth in Article VIII hereof.

            6.8 Employees.  The Seller shall  terminate the employment of all of
its employees, other than Robert E. Klem.

            6.9  Release of Liens.  The Seller  shall on or prior to the Closing
Date  deliver to the 


                                      -27


<PAGE>

Buyer such  documents as are necessary to terminate and release all Liens on the
Purchased Assets,  except for Permitted Liens,  which documents shall be in form
and substance acceptable to the Buyer and shall include without limitation,  all
documents  necessary to terminate of record all Liens on the  Purchased  Assets,
except for Permitted Liens.

            6.10 Change of Corporate Name. The Seller and the Shareholder  agree
to take all action that is necessary to authorize  the amendment of the Seller's
certificate  of  incorporation  to change the corporate  name of the Seller to a
name which does not include the words "JBL  Scientific"  and/or words of similar
meaning.  At or prior to the  Closing,  the  Seller  and the  Shareholder  shall
provide  the  Buyer  with  documentation  reasonably  satisfactory  to the Buyer
evidencing this amendment.

            6.11  Documents of Transfer.  On the Closing Date,  the Seller shall
duly  execute  and  deliver  to the Buyer (i) the  Assignment,  Bill of Sale and
Assumption  Agreement and (ii)  certificates of title  sufficiently  endorsed to
transfer the Vehicles to the Buyer. Any applicable transfer fee shall be paid by
the Seller at the Closing.

            6.12  Nondisclosure  and  Noncompetition  Agreement.  On the Closing
Date, the Seller,  the  Shareholder and Robert E. Klem shall execute and deliver
to the Buyer the Nondisclosure and Noncompetition Agreement.

            6.13 Other Deliveries. On the Closing Date, the Seller shall deliver
to the Buyer the following:

              (a)    The  resolutions  of the Boards of  Directors of the Seller
                     and the  Shareholder and the Shareholder in its capacity as
                     the  sole   shareholder  of  the  Seller   authorizing  and
                     approving the execution and delivery of this  Agreement and
                     performance  by  the  Seller  and  the  Shareholder  of the
                     transactions  contemplated  hereby,  certified on behalf of
                     the  Seller  and  the  Shareholder,  as  applicable,  by an
                     officer of the Seller and the Shareholder, respectively;

              (b)    Current  Uniform  Commercial  Code  and  state,  local  and
                     federal  tax,  sales  and  unemployment  compensation  tax,
                     judgment,  bankruptcy and similar lien searches  showing no
                     Liens  against the  Purchased  Assets other than  Permitted
                     Liens;

              (c)    All  consents  for  the  assignment  of all  Contracts  and
                     Permits,  which are  necessary in order for said  Contracts
                     and Permits to be assigned to the Buyer upon their  present
                     terms (other than those for which,  individually  or in the
                     aggregate,  would not result in a Material  Adverse Effect)
                     and the Seller shall pay all fees,  charges and other costs
                     that are required or imposed in connection  with  obtaining
                     any such consent;

              (d)    An  affidavit  that the  Seller is not a  "foreign  person"
                     within the meaning of Section 1445 of the Code, and stating
                     the Seller's federal  taxpayer  identification  number,  in
                     form and substance acceptable to counsel for the Buyer; and

              (e)    All other documents reasonably requested by counsel for the
                     Buyer to consummate the transactions herein contemplated.


                                      -28-


<PAGE>

            6.14 Collection of the  Receivables.  After the Closing,  subject to
Section  7.10,  the Buyer shall have full power and authority to collect for its
account all Receivables,  and to endorse, without recourse to the Seller, in the
name of the  Seller,  any checks or other  instruments  of payment  received  on
account of payment of any such  Receivables.  Subject to Section 7.10, if, after
the Closing, the Seller receives any payment on account of any such Receivables,
the Seller shall transfer and deliver such payment (endorsed where necessary) to
the Buyer, promptly after receipt.

            6.15 Exclusive Dealing. Neither the Seller, the Shareholder, nor any
of their agents or representatives will take, directly or indirectly, any action
to initiate, continue, assist, solicit, negotiate, encourage or accept any offer
or inquiry  from any Person (a) to engage in any  Business  Combination,  (b) to
reach  any  agreement  or  understanding  (whether  or  not  such  agreement  or
understanding  is  absolute,  revocable,  contingent  or  conditional)  for,  or
otherwise attempt to consummate,  any Business  Combination or (c) to furnish or
cause to be furnished any  information  with respect to the Seller or its assets
to any Person (other than as  contemplated  in this Agreement) who the Seller or
the Shareholder  knows or has reason to believe is in the process of considering
any Business Combination.  For purposes hereof, "Business Combination" means any
merger,  consolidation  or combination to which the Seller is a party, any sale,
dividend,  split or other  disposition of capital stock or other equity interest
of the Seller or any sale, dividend or other disposition of all or substantially
all of the assets of the Seller.

            6.16  Further  Assurances.  The  Seller  and the  Shareholder,  upon
request  of the  Buyer,  shall  execute,  acknowledge  and  deliver  such  other
instruments  as  reasonably  may be requested to more  effectively  transfer the
Purchased Assets to the Buyer or to otherwise carry out the terms and conditions
of this Agreement.

            6.17 Brokerage.  Any brokerage,  finders' or similar fee incurred in
connection  with  the  transactions  contemplated  by this  Agreement  shall  be
promptly paid by the Seller or the Shareholder.

            6.18 Quality  Assurance  Agreement.  On the Closing Date, the Seller
and the Shareholder shall execute and deliver to the Buyer the Quality Assurance
Agreement.

            6.19 Intellectual Property Assignments. On the Closing Date, each of
the  Seller  and the  Shareholder  shall  execute  and  deliver to the Buyer its
Intellectual Property Assignment.

            6.20 Lipid License  Agreement.  On the Closing Date,  the Seller and
the  Shareholder  shall  execute  and  deliver  to the Buyer  the Lipid  License
Agreement.

            6.21 Biogenex License  Agreement.  The Seller shall have consummated
the  transactions  contemplated by the Biogenex  License  Agreement,  including,
without  limitation,  the licensing of the Amadite  technology to the Seller and
any payments required to be made by the Seller has been made.

            6.22 Note. The Note shall be imprinted  with a legend  substantially
in the following form:


                                      -29-


<PAGE>

            THIS NOTE HAS BEEN ACQUIRED FOR  INVESTMENT  AND NOT WITH A VIEW TO,
            OR FOR SALE IN CONNECTION WITH, ANY  DISTRIBUTION  HEREOF WITHIN THE
            MEANING OF THE  SECURITIES  ACT OF 1933, AS AMENDED.  THE PAYMENT OF
            PRINCIPAL AND INTEREST ON THIS NOTE IS SUBJECT TO CERTAIN RECOUPMENT
            PROVISIONS  SET FORTH IN THIS NOTE AND AN ASSET  PURCHASE  AGREEMENT
            DATED AS OF MARCH 19, 1999 (THE  "PURCHASE  AGREEMENT")  BETWEEN THE
            BUYER (AS DEFINED  BELOW),  JBL  SCIENTIFIC  INCORPORATED  AND GENTA
            INCORPORATED. NOTWITHSTANDING ANY OTHER PROVISIONS CONTAINED HEREIN,
            NO TRANSFER OF THIS NOTE SHALL BE MADE UNLESS  CONDITIONS  SPECIFIED
            IN THE  PURCHASE  AGREEMENT  HAVE  BEEN  FULFILLED.  A  COPY  OF THE
            PURCHASE  AGREEMENT IS ON FILE AND AVAILABLE  FOR  INSPECTION AT THE
            PRINCIPAL OFFICE OF THE BUYER.

The Note shall not be assigned or  transferred  (other than to the  Shareholder)
without  the  express  written  consent of the Buyer.  Each  holder  desiring to
transfer  the Note  first  must  furnish  the Buyer  with (i) a written  opinion
satisfactory to the Buyer in form and substance from counsel satisfactory to the
Buyer by reason of  experience  to the effect that the holder may  transfer  the
Note as desired without registration under the Securities Act and (ii) a written
undertaking executed by the desired transferee satisfactory to the Buyer in form
and  substance  agreeing  to be  bound  by the  recoupment  provisions  and  the
restrictions on transfer contained herein and therein; provided, that the Seller
shall be permitted to transfer the Note to the  Shareholder  without  compliance
with clause (i) above.

            6.23 On-Site  Contamination.  With respect to any further monitoring
and possible cleanup of PCE and chloroform contamination at the facility located
at 277 Granada  Drive,  San Luis Obispo,  California  (that  contamination,  the
"On-Site  Contamination"),  the Seller shall comply promptly with all directives
from the Regional Water Quality Control Board and other Governmental Authorities
to remain in material  compliance with all Environmental  Laws, other than those
directives being contested in good faith through  appropriate legal proceedings.
The Seller  shall  determine  what  actions must be taken after the date of this
Agreement to ensure such compliance. The Seller shall provide the Buyer with any
documents to be submitted to any Governmental Authority,  and shall not take any
action with  respect to the  On-Site  Contamination  without  the Buyer's  prior
consent, which may not be unreasonably withheld and must be promptly provided if
it is to be given.  The Seller  shall bear all costs and  expenses  incurred  in
connection with the On-Site Contamination.

            6.24 The Seller's Welfare Plans.  Effective as of the end of the day
immediately  preceding  the Closing Date,  except as otherwise  provided in this
Section 6.24,  Hired Employees shall cease to be covered by the Seller's Welfare
Plans (as  hereinafter  defined)  except  the  Seller  shall be  liable  for any
vacation pay in excess of four (4) weeks per Hired  Employee that has accrued as
of the Closing Date.  The Seller shall be  responsible  for all of the following
claims  under the  Seller's  Welfare  Plans,  which shall be deemed to have been
"incurred"  prior to the Closing Date:  (i) under any medical,  dental or health
plans for any treatment or service  actually  rendered prior to the Closing Date
(but not rendered thereafter), regardless of whether the service or treatment is
part of 


                                      -30-


<PAGE>

an ongoing course of treatment that  commenced  prior to the Closing Date;  (ii)
under any life  insurance  plans with respect to deaths  occurring  prior to the
Closing  Date;  and (iii) for any  payments  or benefits  otherwise  incurred or
arising prior to the Closing Date under any other  Seller's  Welfare  Plan.  The
Seller shall be  responsible  for providing all employees of the Business  whose
employment is terminated by the Seller and who are covered under a "group health
plan" (within the meaning of Section  5000(b)(1) of the Code)  maintained by the
Seller  (the  "Seller's  Group  Health  Plan"),  and the  qualified  spouses and
dependents of these  employees,  with  continuation  coverage under the Seller's
Group Health Plan to the extent required by the provisions of COBRA as currently
set forth in Part 6 of Subtitle B of Title I of ERISA and  Section  4980B of the
Code,  and the  implementing  regulations  promulgated  or proposed under any of
those laws.  The Buyer shall have no  obligation  to provide,  nor any liability
for,  any  benefits  of  any  kind  under  any of the  Seller's  Welfare  Plans,
including, but not limited to, any COBRA benefits under any group health plan of
the Seller,  except to the extent  related to a failure by the Buyer to meet its
obligations  under  Sections 7.8 and 7.13 hereof.  For purposes of this Section,
the "Seller's  Welfare Plans" shall include each "employee welfare benefit plan"
(within  the  meaning of Section  3(1) of ERISA)  and each other  benefit  plan,
program,  policy or  arrangement  that is maintained by the Seller,  that covers
employees  of the Seller who are employed by the Seller in  connection  with the
Business,  and that is not an "employee pension benefit plan" within the meaning
of Section 3(2) of ERISA.

            6.25  The  Seller's  401(k)  Plan.  The  Seller  maintains  the  JBL
Scientific  Savings and Retirement Plan (the "Seller's  401(k) Plan"), a defined
contribution  profit-sharing  plan with a cash or deferred  arrangement  that is
intended  to be  qualified  under  Sections  401(a) and 401(k) of the Code.  The
Seller shall retain  sponsorship  of the Seller's  401(k) Plan after the Closing
Date and  neither  the  Buyer  nor any plan  maintained  by the  Buyer  shall be
entitled to any assets of the Seller's  401(k) Plan.  The Buyer shall not assume
any responsibility or liability for the Seller's 401(k) Plan, and the Seller and
the  Seller's  401(k) Plan shall  remain  solely and  entirely  responsible  for
satisfying any and all obligations  and  liabilities  arising under the Seller's
401(k)  Plan.  The  accrued  benefits  under  the  Seller's  401(k)  Plan of all
participants are 100% vested and non-forfeitable.

                                   ARTICLE VII

                             COVENANTS OF THE BUYER

            The Buyer  covenants and agrees with the Seller and the  Shareholder
as follows:

            7.1  Certified  Resolutions.  On the Closing  Date,  the Buyer shall
deliver to the Seller a copy of the  resolutions  of the Boards of  Directors of
the Buyer and Promega,  authorizing  and approving the execution and delivery of
this Agreement and the performance by the Buyer and Promega of the  transactions
contemplated  hereby,  as  certified  on behalf of the  Buyer  and  Promega,  as
applicable, by an officer of the Buyer and Promega, respectively.

            7.2  Assignment,  Bill  of Sale  and  Assumption  Agreement.  On the
Closing Date, the Buyer shall execute and deliver to the Seller the  Assignment,
Bill of Sale and Assumption Agreement.


                                      -31-


<PAGE>

            7.3 Nondisclosure and Noncompetition Agreement. On the Closing Date,
the Buyer  shall  execute  and  deliver to the Seller  and the  Shareholder  the
Nondisclosure and Noncompetition Agreement.

            7.4 Quality  Assurance  Agreement.  On the Closing  Date,  the Buyer
shall  execute  and  deliver  to the  Seller  and the  Shareholder  the  Quality
Assurance Agreement.

            7.5 Lipid License  Agreement.  On the Closing Date,  the Buyer shall
execute and deliver to the Shareholder the Lipid License Agreement.

            7.6 Note. On the Closing  Date,  the Buyer shall execute and deliver
to the Seller the Note.

            7.7 Lease.  On the Closing Date, the Buyer shall execute and deliver
to Granada Associates, LLC the Lease.

            7.8   Employees.   On  the  Closing  Date,  the  Buyer  shall  offer
employment,  effective as of the Closing  Date,  to all  full-time and part-time
employees of the Seller,  other than Robert E. Klem,  who are active or on leave
for medical or disability reasons or are covered by the Family and Medical Leave
Act of 1993, P.L. 103-3,  with employee  benefits and perquisites  which, in the
aggregate, are substantially comparable to the employee benefits and perquisites
set forth on Schedule 7.8;  provided,  that each  employee  shall receive a base
salary that is no less favorable than the base salary set forth on Schedule 7.8.
Employees  of the Seller who accept the  Buyer's  offers of  employment  and who
become  employees  of the Buyer as of the Closing Date are referred to herein as
"Hired Employees."

            7.9 Preservation of Records.  Subject to the following sentence, the
Buyer shall at its own expense (a) preserve and keep the Records for a period of
five (5) years  from the  Closing  and (b) make the  Records  and its  personnel
available to the Seller or the  Shareholder at their  request.  In the event the
Buyer wishes to destroy any Records  during the time specified  above,  it shall
first  give  thirty  (30)  days'  prior  written  notice to the  Seller  and the
Shareholder  and the  Seller  and the  Shareholder  shall  have the right at its
option and  expense,  upon prior  written  notice given to the Buyer within that
thirty (30) day period,  to take  possession  of the records  within thirty (30)
days after the date of the Seller's notice to the Buyer.

            7.10 Uncollectible Receivables.

            (a) The Buyer shall  promptly  assign each  Receivable to the Seller
upon the end of the 120-day period following the Closing Date.

            (b) The Buyer  shall  afford the Seller  and its  representatives  a
reasonable  opportunity,  during normal business hours, to examine and audit the
books and records of the Buyer with respect to the collection of Receivables.

            (c) For purposes of determining the collections on Receivables,  any
payments  received by the Buyer shall be applied against the oldest account owed
by the Person making the payment 


                                      -32-


<PAGE>

unless that Person  indicates to the Buyer that that  account is in dispute,  in
which event the payment shall be applied against the next oldest Receivable.

            (d) The Buyer shall maintain appropriate records with respect to the
Receivables and shall act in good faith to collect the Receivables in accordance
with the Seller's  past  practices for the  collection  of accounts  receivable;
provided,  however, that in no event shall the Buyer be required to institute or
threaten litigation or refuse to accept any purchase order.

            (e) All  proceeds  of any  Receivable  assigned  by the Buyer to the
Seller  pursuant to Section  7.10(a)  that are  collected by the Buyer after the
date that  Receivable was so assigned  shall be promptly  remitted by the Buyer.
The Buyer  shall  provide to the Seller a copy of such  records  relating to the
Receivables so assigned to the Seller as the Seller may request,  such copies to
be delivered within ten (10) days after the pertinent  Receivable is so assigned
or after such request is made, whichever is later.

            7.11  Access to  Property.  From the Closing  Date,  the Buyer shall
cooperate with the Seller and shall provide the Seller with reasonable access at
reasonable  times to the  facility  located at 277  Granada  Drive,  so that the
Seller may oversee any  monitoring  and cleanup  activities  with respect to the
On-Site  Contamination  required by the Regional  Water  Quality  Control  Board
directives.  From the Closing Date, the Buyer shall allow the Seller to use Greg
Frank for up to fifteen (15) hours each month to assist in the Seller's  efforts
to comply with all directives,  monitoring and clean-up at the facility  located
at 277 Granada Drive;  provided,  that each hour Greg Frank spends assisting the
Seller  shall  reduce  the  Buyer's  obligations  under  the  Quality  Assurance
Agreement by one hour.

            7.12 The Buyer's 401(k) Plan.  Promega  maintains the Promega Profit
Sharing  and  Salary  Deferral  Plan  (the  "Promega  401(k)  Plan"),  a defined
contribution  profit-sharing  plan with a cash or deferred  arrangement  that is
intended to be qualified under Sections 401(a) and 401(k) of the Code. As of the
Closing Date,  coverage  under the Promega  401(k) Plan shall be extended to all
Hired Employees and credit under the Promega 401(k) Plan shall be given to Hired
Employees  for all  their  service  with the  Seller,  solely  for  purposes  of
eligibility  to participate  and vesting,  to the same extent such service would
have been credited if the service had been  performed  for Promega,  and Promega
shall  cause the  Promega  401(k)  Plan to be  amended,  to the  extent (if any)
necessary,  to provide for this crediting of service with the Seller.  After the
Closing  Date,  Promega  shall permit Hired  Employees  who are entitled and who
elect to receive an eligible rollover distribution from the Seller's 401(k) Plan
to direct that the eligible rollover  distribution be transferred to the Promega
401(k) Plan in  accordance  with  Section  402(c) of the Code and Promega  shall
cause the Promega 401(k) Plan to be amended,  to the extent (if any)  necessary,
to permit such transfers.

            The Buyer shall be responsible for all of the following claims under
the Buyer's  Welfare  Plans,  which shall be deemed  "incurred"  on or after the
Closing Date: (i) under any medical, dental or health plans for any treatment or
service  actually  rendered  on or after (but not  rendered  before) the Closing
Date,  regardless  of whether  the  service or  treatment  is part of an ongoing
course of treatment  that  commenced  prior to the Closing Date,  (ii) under any
life  insurance  plans with respect to deaths  occurring on or after the Closing
Date,  and (iii) for any  payments or benefits  incurred on or after the Closing
Date under any other Buyer Welfare Plan.


                                      -33-


<PAGE>

            7.13 The  Buyer's  Welfare  Plans.  The Buyer  shall  not  assume or
continue any of the Seller's  Benefit  Plans.  As of the Closing Date, the Buyer
shall provide Hired Employees with employee  benefit plans,  programs,  policies
and  arrangements  (the  "Buyer's  Welfare  Plans") that provide  benefits on an
aggregate basis which are comparable to the benefits provided to Hired Employees
immediately prior to the Closing under the Seller's Welfare Plans.  Specifically
with  respect to medical  and other  health-related  benefits,  the Buyer  shall
provide  each  Hired  Employee  (and  each such  Hired  Employee's  spouses  and
dependents) with immediate coverage as of the Closing Date under a "group health
plan"  (within the  meaning of Section  5001(b) of the Code)  maintained  by the
Buyer (the  "Buyer's  Group Health  Plan") that  provides  benefits and includes
terms and  conditions  which are  substantially  similar  to or better  than the
benefits  provided and terms and  conditions  included  under the Seller's group
health plan in which each Hired Employee  participated  immediately prior to the
Closing,  and the Buyer shall waive any  pre-existing  condition  exclusions  or
restrictions with respect to Hired Employees under the Buyer's Group Health Plan
to the same extent as coverage is provided under the Seller's Group Health Plan.
Each Hired Employee shall receive credit under the Buyer's group health plan for
all amounts paid by each Hired Employee in calendar year 1999 under the Seller's
group health plan for purposes of any  applicable  deductibles,  co-payments  or
out-of-pocket  maximums.  The Buyer shall be solely  responsible  for  providing
Hired Employees with any continuation coverage (and shall have sole liability in
respect of any failure to provide  such  continuation  coverage)  under  Section
4980B of the Code or Part 6 of Subtitle B or Title I of ERISA resulting from any
"qualifying event" occurring on or after the Closing Date. The Buyer shall grant
full credit to Hired  Employees,  under the Buyer's  Welfare  Plans that are not
group health plans, for service with the Seller (or with a predecessor  employer
to the  extent  credited  under the  corresponding  Seller's  Welfare  Plan) for
purposes  of  (i)  satisfying  any  and  all   eligibility   and   participation
requirements under the Buyer's Welfare Plans and (ii) determining the amount and
duration  of any  benefits  under the Buyer's  Welfare  Plans to the extent that
service or seniority is a  consideration  in calculating  benefits but the Buyer
shall not be required to credit any service that would  result in a  duplication
of benefits.  The Seller shall have no obligation to provide,  nor any liability
for,  any  benefits  of any kind to Hired  Employees  under  any of the  Buyer's
Welfare Plans,  including,  but not limited to, COBRA benefits under any Buyer's
Group Health Plan.

            7.14 Employment  Terms and Benefits after the Closing Date.  Nothing
in this  Agreement  shall be construed to limit or restrict the Buyer in any way
after the Closing Date with respect to (i) the Buyer's  conduct of the Business;
(ii) the Buyer's  modification  or change in the terms of employment  (including
the  termination  of employment)  of any Hired  Employee;  and (iii) the Buyer's
modification,  amendment or termination of any employee  benefit plan maintained
or contributed to by the Buyer,  including but not limited to any of the Buyer's
Welfare Plans; provided, however, within ninety (90) days from the Closing Date,
no such amendment or  modification  shall be  inconsistent  with the requirement
that Hired  Employees  receive  immediate  coverage  under a group  health  plan
pursuant to Section 7.13.

            7.15 Product Liability Claims. If the Buyer  successfully  asserts a
claim  against  the Seller or the  Shareholder  with  respect to a breach of the
representations  or  warranties  contained  in  Section  4.26,  the Buyer  shall
promptly  assign any rights and remedies,  under warranty or otherwise,  against
the  manufacturers,  vendors or other  Persons for any  defects in the  Purchase
Asset giving rise to such claim.


                                      -34-


<PAGE>

            7.16 Minimum Net Book Value.  From and after the Closing Date, until
the third  anniversary  of the Closing  Date,  the Buyer shall not cause its Net
Book Value to be more than $500,000  less than the Final Net Book Value,  unless
Promega  agrees to  indemnify  the Seller and the  Shareholder  with  respect to
Assumed  Liabilities  as set  forth in  Article  XI and to  assume  the  Buyer's
obligations under Article XI.

                                  ARTICLE VIII

                  CONDITIONS OF THE BUYER'S OBLIGATION TO CLOSE

            The  obligation  of  the  Buyer  to  consummate   the   transactions
contemplated  by  this  Agreement  shall  be  subject  to the  satisfaction  and
fulfillment  or  waiver,  prior to and on the  Closing  Date,  of the  following
express conditions precedent:

            8.1  Representation   and  Warranties.   The   representations   and
warranties in this  Agreement  made by the  Shareholder  and the Seller shall be
true and correct in all material respects as of and at the Closing Date with the
same force and effect as though said  representations  and  warranties  had been
again made on the Closing Date, and each of the Seller and the Shareholder shall
have  furnished the Buyer a  certificate  to that effect signed on behalf of the
Seller and the Shareholder and by an officer of the Seller and the  Shareholder,
respectively.

            8.2  Performance of Covenants and  Obligations.  The Shareholder and
the Seller shall have  performed and complied in all material  respects with all
of  their  covenants  and  obligations  under  this  Agreement  which  are to be
performed or complied with by them prior to or on the Closing Date,  and each of
the Seller and the  Shareholder  shall have furnished the Buyer a certificate to
that effect signed on behalf of the Shareholder and the Seller and by an officer
of the Seller and the Shareholder, respectively.

            8.3  Proceedings  and  Instruments  Satisfactory.  All  proceedings,
corporate  or  otherwise,  to be  taken  in  connection  with  the  transactions
contemplated by this Agreement,  and all documents  incident  thereto,  shall be
satisfactory  in form and  substance  to the Buyer.  The Seller  shall have made
available to the Buyer for  examination the originals or true and correct copies
of all documents  which the Buyer  reasonably may request in connection with the
transactions contemplated by this Agreement.

            8.4 Adverse  Change.  From and after the date of this  Agreement and
until the Closing Date, the Buyer shall have  reasonably  determined  that there
has been no event or condition  which has resulted in a Material  Adverse Effect
in the Business.  Each of the Seller and the  Shareholder  shall have  furnished
with the Buyer a certificate to that effect signed on behalf of the  Shareholder
and  the  Seller  and  by  an  officer  of  the  Seller  and  the   Shareholder,
respectively.

            8.5  No  Litigation.   No  investigation,   suit,  action  or  other
proceeding shall be threatened or pending before any  Governmental  Authority in
which it is sought to  restrain,  prohibit or obtain  


                                      -35-


<PAGE>

damages or other relief in connection with this Agreement or the consummation of
the transactions contemplated hereby.

            8.6 Consents, Approvals,  Certifications,  Licenses and Permits. All
necessary consents, approvals, certifications, licenses and permits with respect
to the transaction  contemplated  hereby,  including,  without  limitation,  the
transfer of the Purchased Assets to the Buyer, the absence of which would have a
Material Adverse Effect.

            8.7 Good Standing Certificates. The Seller and the Shareholder shall
have delivered to the Buyer current  certificates  of good standing  relative to
the Seller and the Shareholder  recently  certified by the Secretary of State or
other appropriate  governmental authority of each state or jurisdiction in which
the Seller and the  Shareholder,  as  applicable,  are organized or qualified to
transact business.

            8.8 Opinion of  Counsel.  On the  Closing  Date,  the Seller and the
Shareholder shall have delivered to the Buyer the legal opinions of Kramer Levin
Naftalis & Frankel LLP and Sinsheimer,  Schiebelhut & Baggett, the Shareholder's
and the Seller's  counsel,  in  substantially  the form of Exhibits A-1 and A-2,
respectively, attached hereto.

            8.9 Due  Diligence.  On or prior to March 22, 1999,  the Buyer shall
have conducted a due diligence investigation and review of the Purchased Assets,
the Assumed  Liabilities,  the Business and all matters  pertaining thereto that
the Buyer deems relevant and the results of such  investigation and review shall
be  satisfactory  to the Buyer in its sole and absolute  discretion,  including,
without  limitation,  any due diligence  investigation  relating to the Seller's
Intellectual Property and existing  Environmental Claims. This Section 8.9 shall
terminate on 12:01 a.m. Eastern Time on March 23, 1999.

            8.10 Approval by the Shareholder's  Shareholders.  A majority of the
voting  power of the  Shareholder's  holders  of voting  securities  shall  have
delivered to the Shareholder a written consent in the form previously  delivered
to the Buyer.

            8.11 Lease.  Granada  Associates,  LLC shall have  entered  into the
Lease.

                                   ARTICLE IX

                 CONDITIONS TO THE SELLER'S OBLIGATION TO CLOSE

            The  obligation of the Seller and the  Shareholder to consummate the
transactions contemplated by this Agreement shall be subject to the satisfaction
and  fulfillment  or waiver,  prior to and on the Closing Date, of the following
express conditions precedent:

            9.1   Representations   and  Warranties.   The  representations  and
warranties  in this  Agreement  made by the Buyer and Promega  shall be true and
correct in all  material  respects as of and at the  Closing  Date with the same
force and effect as though said  representations  and  warranties had been again
made on the Closing Date, and each of the Buyer and Promega shall have furnished
the  Seller a  certificate  to that  effect  signed  on  behalf of the Buyer and
Promega by an officer of the Buyer and Promega, respectively.


                                      -36-


<PAGE>

            9.2 Performance of Covenants and Obligations.  The Buyer and Promega
shall have  performed and complied  with all of its  covenants  and  obligations
under this  Agreement  which are to be performed or complied with by it prior to
or on the Closing Date,  and each of the Buyer and Promega shall have  furnished
the  Seller a  certificate  to that  effect  signed  on  behalf of the Buyer and
Promega by an officer of the Buyer and Promega, respectively.

            9.3  Proceedings  and  Instruments  Satisfactory.  All  proceedings,
corporate  or  otherwise,  to be  taken  in  connection  with  the  transactions
contemplated by this Agreement,  and all documents  incident  thereto,  shall be
reasonably  satisfactory  in form and  substance  to the Seller;  and, the Buyer
shall have made  available to the Seller for  examination  the originals or true
and correct  copies of all documents  which the Buyer  reasonably may request in
connection with the transactions contemplated by this Agreement.

            9.4  No  Litigation.   No  investigation,   suit,  action  or  other
proceeding shall be threatened or pending before any  Governmental  Authority in
which it is sought to  restrain,  prohibit or obtain  damages or other relief in
connection  with  this  Agreement  or  the   consummation  of  the  transactions
contemplated hereby.

            9.5 Opinion of Counsel.  On the Closing Date,  the Buyer and Promega
shall have  delivered  the legal  opinion of Michael  Best & Friedrich  LLP, the
Buyer's and Promega's counsel, in substantially the form of Exhibit A-3 attached
hereto.

                                    ARTICLE X

                    INDEMNIFICATION BY SELLER AND SHAREHOLDER

            10.1 Indemnification. Notwithstanding the Closing, and regardless of
any investigation  made by, or on behalf of, the Buyer, or any information known
to the Buyer, the Seller and the Shareholder (collectively,  the "Indemnitors"),
subject to the terms and  conditions  of this Article X, jointly and  severally,
indemnify and save the Buyer, its shareholders, officers, directors or employees
(collectively,  the "Buyer" as used in this Article X) harmless from and against
any  and  all  losses,  claims,   damages,   liabilities,   costs,  expenses  or
deficiencies including, but not limited to, reasonable attorneys' fees and other
costs and expenses, and including simple interest thereon at the Applicable Rate
(collectively, "Losses") reasonably incident to proceedings or investigations or
the  defense or  settlement  of any claim or  claims,  incurred  by or  asserted
against the Buyer or the  Purchased  Assets due to or resulting  from any of the
following: (a) the inaccuracy or breach of any representation or warranty of the
Seller or the Shareholder given in or pursuant to this Agreement; (b) any breach
or default in the  performance by the Seller or the  Shareholder of any of their
covenants,  obligations or agreements in or pursuant to this Agreement;  (c) any
liability  or  obligation  of the  Seller  not  expressly  assumed  by the Buyer
pursuant to this Agreement;  and (d) the ownership or conduct of the Business or
the ownership or use of the Seller's assets at any time prior to the Closing, or
any incident, occurrence, condition or claim existing, arising or accruing prior
to the Closing and  relating to the  operation or conduct of the Business or the
ownership or use of the Seller's  assets  (including,  without  limitation,  all
Losses due to Environmental Claims,  Environmental  Releases by any Person prior
to the  Closing  Date)  other than any  liability  or  obligation  of the Seller
expressly  assumed by the Buyer  pursuant to this  Agreement.  The foregoing are
collectively  referred to as  "Indemnifiable  Damages." The term  "Indemnifiable
Damages"  shall  also  include  an  amount  of  interest  on the  amount of such
Indemnifiable Damages (computed before the application of this sentence),  which
interest shall be computed at the Applicable  Rate in simple  interest per annum
from the Closing Date and until paid by the Indemnitors.

            10.2 Procedures for Making Claims.  If and when the Buyer desires to
assert a claim for Indemnifiable Damages against the Indemnitors pursuant to the
provisions  of this  Article  X, the Buyer  shall  deliver  to the  Indemnitors,
reasonably  promptly  after  the  Buyer's  receipt  of a claim or  specific  and
affirmative  awareness of a potential claim, a certificate  signed by an officer
(the  "Notice of  Claim"):  (a)  stating  that the Buyer has paid or accrued (or
intends  to pay or accrue)  Indemnifiable  Damages  to which it is  entitled  to
indemnification pursuant to this Article X and the amount thereof (to the extent
then known);  and (b) specifying to the extent possible (i) the individual items
of loss, damage,  liability,  cost, expense or deficiency included in the amount
so stated, (ii) the date each such item was or will be paid or accrued and (iii)
the basis upon which Indemnifiable Damages are claimed. If the Indemnitors shall
object to such Notice of Claim,  the Indemnitors  shall  simultaneously  deliver
written  notice of  objection  (the "Notice of  Objection")  to the Buyer within
thirty (30) days after the Buyer's  delivery of the Notice of Claim.  The Notice
of Objection  shall set forth the grounds upon which the  objection is based and
state  whether  the  Indemnitors  object to all or only a portion  of the matter
described in the Notice of Claim. If the Notice of Objection shall not have been
so  delivered  within  such thirty (30) day  period,  all  Indemnitors  shall be
conclusively  deemed to have acknowledged the correctness of the claim or claims
specified  in the  Notice  of  Claim  for  the  full  amount  thereof,  and  the
Indemnifiable  Damages  set forth in the  Notice  of Claim  shall be paid to the
Buyer, on demand, in cash.


                                      -38-


<PAGE>

            10.3  Participation  in Defense of Third Party Claims.  If any third
party shall  assert any claim  against the Buyer  which,  if  successful,  might
result in an  obligation of the  Indemnitors  to pay  Indemnifiable  Damages and
which can be remedied to the reasonable satisfaction of the Buyer by the payment
of  money  damages  without  further  adverse  consequence  to  the  Buyer,  the
Indemnitors,  at the sole  expense of the  Indemnitors,  may assume the  primary
defense thereof with counsel reasonably acceptable to the Buyer, but only if and
so long as: (a) the Indemnitors diligently pursue the defense of such claim; and
(b) the  Indemnitors  acknowledge  to the Buyer in writing  that the  claim,  if
resolved  or  settled  with an  acknowledgement  that  the  Indemnitors  have an
indemnification claim hereunder,  is one for which the Indemnitors are obligated
to indemnify the Buyer  hereunder.  Except with the prior written consent of the
Buyer,  which shall not be  unreasonably  withheld,  the  Indemnitors  shall not
consent to entry of any judgment,  or enter into any  settlement,  that provides
for injunctive or other nonmonetary  relief affecting the Buyer or that does not
include  as an  unconditional  term  thereof  the  giving  by each  claimant  or
plaintiff  to the Buyer of a release  from all  liability  with  respect to such
claim or litigation. If the Indemnitors fail or are unable to so elect to assume
the primary  defense of any such  claim,  the Buyer may (but need not) do so, in
which event the Buyer may defend, settle or compromise the claim, at the expense
and cost of the  Indemnitors,  in any such manner as the Buyer  reasonably deems
appropriate;  provided,  that,  except  with the prior  written  consent  of the
Indemnitors,  which  shall not be  unreasonably  withheld,  the Buyer  shall not
consent to entry of any judgment,  or enter into any  settlement,  that provides
for injunctive or other  nonmonetary  relief affecting either of the Indemnitors
or that does not  include as an  unconditional  term  thereof the giving by each
claimant or plaintiff to the  Indemnitors  of a release from all liability  with
respect to such claim or litigation.

            10.4   Survival  of   Representations   and   Indemnification.   The
Indemnitor's  obligation  to pay  Indemnifiable  Damages  arising  out of claims
described  in Sections  10.1(b),  (c) and (d) shall  survive the Closing of this
transaction  indefinitely.  The  representations  and  warranties  contained  in
Article IV, and the Indemnitor's obligation to pay Indemnifiable Damages arising
out of Section 10.1(a) hereof, shall survive the Closing Date, as follows:

            (a) Fraudulent Breach of Representations;  Certain  Representations.
In the case of a claim based upon the  inaccuracy or breach of a  representation
or warranty which was made fraudulently or with respect to any representation or
warranty  contained  in Sections  4.1,  4.2,  4.3,  4.4(a),  4.5,  4.6 and 4.30,
indefinitely;

            (b)  Taxes;  Environmental.  In the case of a claim  based  upon the
inaccuracy or breach of a representation or warranty  contained in Sections 4.21
and 4.23, for a period equal to the applicable statute of limitations;

            (c) Inventories. In the case of a claim based upon the inaccuracy or
breach of a  representation  or warranty  contained in Section  4.14,  until the
Closing Balance Sheet has been finalized  pursuant to Section 2.2(c)-(d) and any
required payment has been made pursuant to Section 2.2(f); and


                                      -39-


<PAGE>

            (d) All Other Claims. In the case of all other claims based upon the
inaccuracy  or breach of any  other  representation  or  warranty  contained  in
Article  IV, for a period  commencing  on the date  hereof and ending  three (3)
years after the Closing Date.

No claim for  recovery of  Indemnifiable  Damages  arising  out of Section  10.1
hereof may be asserted by the Buyer after the expiration of the applicable  time
period described in this Section 10.4; provided,  however,  that any claim first
asserted  by the  giving of a Notice of Claim  within  the  applicable  survival
period shall neither be abated nor barred.

            10.5  Limitations  on  Indemnifiable  Damages.  Notwithstanding  the
foregoing,  other than  Indemnifiable  Damages  (a) due to fraud or  intentional
misrepresentation  on behalf of the Seller or the Shareholder or (b) arising out
of an  inaccuracy  or breach of any  representations  or warranty  contained  in
Sections 4.1, 4.2, 4.3,  4.4(a),  4.5, 4.6, 4.21, 4.23 and 4.30, for which there
shall be no  limitation  on the  Seller's  breach,  (x) the  maximum  amounts of
Indemnifiable  Damages payable by the Seller and the  Shareholder  arising under
Section  10.1(a) shall not exceed the Purchase Price and (y) the Buyer shall not
be entitled to recover Indemnifiable Damages for any matter described in Section
10.1(a) unless and until the aggregate of all claims for  Indemnifiable  Damages
asserted pursuant to Section 10.1(a) exceeds $25,000.

            10.6  Offset.  The Buyer  shall be  entitled  to offset  against any
obligations  owed by the Buyer to the Indemnitors  the sum of all  Indemnifiable
Damages  that the  Buyer is  entitled  to  pursuant  to  Article X and all other
obligations  owed by the Buyer to the  Indemnitors  under  any other  agreement,
contract or other arrangement. Without limiting the generality of the foregoing,
the  Buyer  shall  have  the  option  of  recouping  all  or  any  part  of  any
Indemnifiable  Damages it may suffer (in lieu of seeking any  indemnification to
which it is  entitled  under this  Article X) by  notifying  the Seller that the
Buyer is reducing the  principal  amount  outstanding  under the Note. No offset
made by the Buyer pursuant to this Section 10.6 shall constitute a default under
any of the Buyer's payment obligations or, even if it is subsequently determined
that no Indemnifiable Damages or other obligations were due the Buyer, give rise
to any right of acceleration under the Note or any other agreement,  contract or
understanding on the part of any of the Indemnitors by reason of such offset.

            10.7 Other Indemnification Provisions. The foregoing indemnification
provisions  are in  addition  to,  and  not in  derogation  of,  any  statutory,
equitable,  or common law remedy (including  without  limitation any such remedy
arising under  Environmental Law) the Buyer may have with respect to the Seller,
the   Shareholders   or  the   transactions   contemplated  by  this  Agreement.
Notwithstanding the foregoing,  each of the Buyer and Promega hereby agrees that
it will not make, and agrees that its officers,  directors or employees will not
make, any claim for indemnification against any Person who is or was a director,
officer,  employee,  or agent of any of the Seller,  the  Shareholder  and their
Affiliates  or was  serving  at the  request  of any such  entity as a  partner,
trustee,  director,  officer,  employee,  or agent of another  entity (each such
Person, a "Protected  Shareholder Person") (whether such claim is for judgments,
damages, penalties, fines, costs, amounts paid in settlement,  losses, expenses,
or  otherwise  and  whether  such  claim is  pursuant  to any  statute,  charter
document,  bylaw,  agreement,  or otherwise)  with respect to any action,  suit,
proceeding,  complaint,  claim,  or demand  brought  by the Buyer or  Promega in
connection with the transactions contemplated by this Agreement.


                                      -40-


<PAGE>

                                   ARTICLE XI

                            INDEMNIFICATION BY BUYER

            11.1 Indemnification. Notwithstanding the Closing, and regardless of
any  investigation  made by, or on behalf of, the Seller or Shareholder,  or any
information known to the Seller or Shareholder,  the Buyer, subject to the terms
and  conditions  of this  Article XI,  indemnifies  and saves the Seller and the
Shareholder   and  their   shareholders,   officers,   directors   or  employees
(collectively,  the "Indemnitees") harmless from and against any and all Losses,
reasonably   incident  to  proceedings  or  investigations  or  the  defense  or
settlement  of  any  claim  or  claims,  incurred  by or  asserted  against  the
Indemnitees  due to:  (a) the  inaccuracy  or  breach of any  representation  or
warranty of the Buyer or Promega given in or pursuant to this Agreement; (b) any
breach or  default  in the  performance  by the  Buyer of any of its  covenants,
obligations  or  agreements  in or pursuant to this  Agreement;  (c) any Assumed
Liabilities;  (d) Losses  relating to the  operations of the Business  after the
Closing Date, including, without limitation,  Losses from Environmental Releases
caused by the operations of the Business and Environmental Claims resulting from
the  operations of the Business  after the Closing;  and (e) Losses arising from
the Buyer's due  diligence  activities  at the Real Estate prior to the Closing,
including, without limitation any soil or groundwater testing conducted by or on
behalf of the Buyer.  The  foregoing  are  collectively  referred  to as "Seller
Indemnifiable  Damages."  The term  "Seller  Indemnifiable  Damages"  shall also
include  an amount of  interest  on the  amount  of such  Indemnifiable  Damages
(computed  before the  application  of this  sentence),  which interest shall be
computed at the  Applicable  Rate simple  interest  per annum from the date such
Seller Indemnifiable Damages were incurred by the Indemnitees and until paid.

            11.2  Procedures  for  Making  Claims.  If and when the  Indemnitees
desire to assert a claim for  Seller  Indemnifiable  Damages  against  the Buyer
pursuant to the provisions of this Article XI, the Indemnitees  shall deliver to
the Buyer,  reasonably  promptly  after the  Indemnitees'  receipt of a claim or
awareness of a potential  claim, a certificate  signed by the  Indemnitees  (the
"Seller Notice of Claim"): (a) stating that the Indemnitees have paid or accrued
(or  intend to pay or  accrue)  Seller  Indemnifiable  Damages to which they are
entitled to  indemnification  pursuant to this Article XI and the amount thereof
(to the extent then known);  and (b)  specifying to the extent  possible (i) the
individual  items  of loss,  damage,  liability,  cost,  expense  or  deficiency
included  in the amount so  stated,  (ii) the date each such item was or will be
paid or accrued and (iii) the basis upon which Seller Indemnifiable  Damages are
claimed.  If the Buyer  shall  object to such  Notice of Claim,  the Buyer shall
deliver  written  notice of objection  (the "Seller Notice of Objection") to the
Indemnitees  within  thirty  (30) days after the  Indemnitee's  delivery  of the
Seller  Notice of Claims.  The Seller  Notice of  Objection  shall set forth the
grounds upon which the objection is based and state whether the Buyer objects to
all or only a portion of the matter  described in the Seller Notice of Claim. If
the Seller  Notice of Claim shall not have been so delivered  within such thirty
(30) day period, the Buyer shall be conclusively deemed to have acknowledged the
correctness  of the claim or claims  specified in the Seller Notice of Claim for
the full amount  thereof and the Seller  Indemnifiable  Damages set forth in the
Seller Notice of Claim shall be paid to the Indemnitees, on demand, in cash.


                                      -41-


<PAGE>

            11.3  Participation  in Defense of Third Party Claims.  If any third
party shall assert any claim against the Indemnitees which, if successful, might
result in an obligation of the Buyer to pay Seller  Indemnifiable  Damages,  and
which  can be  remedied  to the  reasonable  satisfaction  of the  Seller by the
payment of money damages without further adverse consequences to the Seller, the
Buyer, at the sole expense of the Buyer,  may assume the primary defense thereof
with counsel reasonably  acceptable to the Indemnitees,  but only if and so long
as: (a) the Buyer  diligently  pursues the  defense of such  claim;  and (b) the
Buyer  acknowledges to the Indemnitees in writing that the claim, if resolved or
settled  with an  acknowledgement  that the Buyer has an  indemnification  claim
hereunder,  is one for which the Buyer is obligated to indemnify the Indemnitees
hereunder. Except with the prior written consent of the Indemnitees, which shall
not be  unreasonably  withheld,  the  Buyer  shall not  consent  to entry of any
judgment,  or enter into any  settlement,  that provides for injunctive or other
nonmonetary  relief  affecting  the  Indemnitees  or that does not include as an
unconditional  term  thereof  the giving by each  claimant or  plaintiff  to the
Indemnitees  of a release  from all  liability  with  respect  to such  claim or
litigation.  If the Buyer  fails or refuses  so to elect to assume  the  primary
defense of any such claim,  the  Indemnitees  may (but need not) do so, in which
event the  Indemnitees  may defend,  settle or compromise  the claim in any such
manner as the Indemnitees  reasonably deem  appropriate;  provided,  that except
with the prior  written  consent of the Buyer,  which shall not be  unreasonably
withheld,  the Indemnitees shall not consent to entry of any judgment,  or enter
into any settlement,  that provides for injunctive or other  nonmonetary  relief
affecting  the Buyer or that does not include as an  unconditional  term thereof
the giving by each  claimant  or  plaintiff  to the Buyer of a release  from all
liability with respect to such claim or litigation.

            11.4  Survival of  Indemnification.  The Buyer's  obligation  to pay
Seller Indemnifiable Damages arising out of claims described in Section 11.1(b),
(c), (d) and (e) shall survive the Closing of this transaction indefinitely. The
representations   and  warranties   contained  in  Article  V  and  the  Buyer's
obligations to pay  Indemnifiable  Damages  arising out of Section 11.1(a) shall
survive the Closing Date, as follows:

            (a) Fraudulent Breach of Representations;  Certain  Representations.
In the case of a claim based upon the  inaccuracy or breach of a  representation
or warranty which was made fraudulently or with respect to any representation or
warranty contained in Sections 5.1, 5.2, 5.3, 5.4(a) and 5.6, indefinitely; and

            (b) All Other Claims. In the case of all other claims based upon the
inaccuracy or breach of a representation or warranty contained in Article V, for
a period  commencing  on the date  hereof and ending  three (3) years  after the
Closing Date.

No claim for recovery of  Indemnifiable  Damages  arising out of Section 11.1(a)
hereof may be asserted by the Indemnitee  after the expiration of the applicable
time period described in this Section 11.4;  provided,  however,  that any claim
first  asserted by the giving of a Seller Notice of Claim within the  applicable
survival period shall neither be abated nor barred.

            11.5  Limitations  on  Indemnifiable  Damages.  Notwithstanding  the
foregoing,  other  than  Seller  Indemnifiable  Damages  (a)  due  to  fraud  or
intentional  misrepresentation  on behalf of the Buyer or Promega or (b) arising
out of an inaccuracy or breach of any  representation  or warranty  contained in
Sections 5.1, 5.2, 5.3,  5.4(a) or 5.6, for which there shall be no  limitation,
(x) the  


                                      -42-


<PAGE>

maximum  amount of Seller  Indemnifiable  Damages on the  Buyer's  or  Promega's
breach  payable by the Buyer arising under Section  11.1(a) shall not exceed the
Purchase  Price and (y) the  Seller  shall not be  entitled  to  recover  Seller
Indemnifiable  Damages for any matter  described in Section  11.1(a)  unless and
until the aggregate of all claims for Indemnifiable Damages asserted pursuant to
Section 11.1(a) exceeds $25,000.

            11.6  Offset.  The Seller and the  Shareholder  shall be entitled to
offset  against any  obligations  owed by the Seller or the  Shareholder  to the
Buyer or Promega the sum of all Seller Indemnifiable  Damages that the Seller or
the Shareholder is entitled to pursuant to Article XI and all other  obligations
owed by the Seller or the  Shareholder  to the Buyer or Promega  under any other
agreement,  contract or other  arrangement.  No offset made by the Seller or the
Shareholder  pursuant to this Section 11.6 shall  constitute a default under any
of the  Seller's  or the  Shareholder's  payment  obligations  or, even if it is
subsequently   determined  that  no  Seller   Indemnifiable   Damages  or  other
obligations  were due the Seller or the  Shareholder,  give rise to any right of
acceleration under any other agreement, contract or understanding on the part of
the Seller or the Shareholder by reason of such offset.

            11.7 Other Indemnification Provisions. The foregoing indemnification
provisions  are in  addition  to,  and  not in  derogation  of,  any  statutory,
equitable, or common law remedy the Seller may have with respect to the Buyer or
the transactions contemplated by this Agreement.  Notwithstanding the foregoing,
each of the Seller and the  Shareholder  hereby agrees that it will not make any
claim for indemnification against any Person who is or was a director,  officer,
employee,  or agent of any of the Buyer,  Promega  and their  Affiliates  or was
serving at the  request  of any such  entity as a  partner,  trustee,  director,
officer,  employee,  or agent of another entity (each such Person,  a "Protected
Promega  Person")  (whether  such claim is for  judgments,  damages,  penalties,
fines, costs,  amounts paid in settlement,  losses,  expenses,  or otherwise and
whether  such  claim  is  pursuant  to any  statute,  charter  document,  bylaw,
agreement,   or  otherwise)  with  respect  to  any  action,  suit,  proceeding,
complaint, claim, or demand brought by the Seller against the Buyer or Promega.

                                   ARTICLE XII

                                   TERMINATION

            12.1 Rights to  Terminate.  This  Agreement may be terminated at any
time prior to the Closing only as follows:

              (a)    by mutual written  consent of the Seller,  the  Shareholder
                     and the Buyer;

              (b)    by the Buyer by giving written notice to the Seller and the
                     Shareholder  on or before March 22,  1999,  if the Buyer is
                     not satisfied with the results of its continuing  business,
                     legal and accounting due diligence of the Seller.

              (c)    by the Seller and the  Shareholder by giving written notice
                     to  the   Buyer  if  the   Buyer  is  in   breach   of  any
                     representation,  warranty or covenant  under this Agreement
                     (and  


                                      -43-


<PAGE>

                     neither the Seller nor the  Shareholder  are then in breach
                     of any representation, warranty or covenant);

              (d)    by the Buyer by giving written notice to the Seller and the
                     Shareholder if the Seller or the  Shareholder are in breach
                     of any  representation,  warranty  or  covenant  under this
                     Agreement  (and  the  Buyer is not  then in  breach  of any
                     representation, warranty or covenant); or

              (e)    by either the Buyer or the Seller  and the  Shareholder  by
                     giving  written  notice to the other parties if the Closing
                     shall not have occurred on or before May 15, 1999.

            Each party's right to termination hereunder is in addition to any of
the rights it may have hereunder or otherwise.

            12.2 Effects of Termination.  Notwithstanding any other provision of
this Agreement,  no termination of this Agreement shall release any party of any
Liabilities  arising  hereunder  for  any  pre-termination  breaches  hereof  or
intentional misrepresentations made herein.

                                  ARTICLE XIII

                                    GUARANTEE

            13.1  Guarantee  by  the   Shareholder.   The   Shareholder   hereby
irrevocably,  absolutely and unconditionally guarantees to the Buyer and Promega
(a) the  payment  of all  amounts  due and  payable  by the  Seller  under  this
Agreement  and each  other  agreement,  document  and  instrument  executed  and
delivered by the Seller in connection with the transactions contemplated by this
Agreement and (b) the  performance  of all agreements  and  undertakings  of the
Seller under this  Agreement and each other  agreement,  document and instrument
executed  and  delivered  by the  Seller  in  connection  with the  transactions
contemplated  by this  Agreement,  in each case strictly in accordance  with the
terms hereof or thereof.

            13.2 Guarantee by Promega.  Promega hereby  irrevocably,  absolutely
and unconditionally  guarantees to the Seller and the Shareholder the payment of
the Purchase  Price,  including the payment of  obligations  under the Note, the
performance of the Buyer's obligations under Article VII, the Buyer's obligation
to consummate the transactions  contemplated by this Agreement if the provisions
of Article VIII of this Agreement are satisfied,  the Buyer's  obligations under
the Lease and the Buyer's obligations under the Quality Assurance Agreement.


                                      -44-


<PAGE>

                                   ARTICLE XIV

                                   DEFINITIONS

            14.1 Certain Defined Terms. As used in this Agreement, the following
terms shall have the meanings  specified in this Section 14.1 unless the context
otherwise requires.

            "Adjustment Amount" has the meaning set forth in Section 2.1(a)(ii).

            "Affiliate"  has  the  meaning  set  forth  in  Rule  12b-2  of  the
regulations promulgated under the Securities Exchange Act.

            "Agreement" means this Asset Purchase  Agreement,  together with all
Exhibits and Schedules hereto, as amended,  restated,  supplemented or otherwise
modified from time to time in accordance with the terms hereof.

            "Applicable Rate" means 7% per annum.

            "Assignment,  Bill of Sale  and  Assumption  Agreement"  means  that
Assignment, Bill of Sale and Assumption Agreement, dated as of the Closing Date,
between  the  Seller  and the  Buyer,  in  substantially  the form of  Exhibit B
attached hereto.

            "Assumed Liabilities" has the meaning set forth in Section 3.1.

            "Benefit Plans" has the meaning set forth in Section 4.25(a).

            "Biogenex  License  Agreement" means that certain license  agreement
dated as of January 20, 1999, between the Seller and Biogenex, Inc.

            "Business"  has  the  meaning  set  forth  in the  recitals  to this
Agreement.

            "Business Combination" has the meaning set forth in Section 6.15.

            "Buyer"  has the meaning  set forth in the first  paragraph  to this
Agreement.

            "Buyer's Accountants" has the meaning set forth in Section 2.2(c).

            "Buyer's  Group  Health  Plan" has the  meaning set forth in Section
7.13.

            "Buyer's  Welfare  Plans" has the  meaning  set forth for in Section
7.13.

            "Closing" has the meaning set forth in Section 1.4.

            "Closing Balance Sheet" has the meaning set forth in Section 2.2(c).


                                      -45-


<PAGE>

            "Closing Date" has the meaning set forth in Section 1.4.

            "COBRA" has the meaning set forth in Section 4.25(d).

            "Code" means the Internal Revenue Code of 1986, as amended.

            "Commission"   means  the  United  States  Securities  and  Exchange
Commission.

            "Commission Filings" has the meaning set forth in Section 4.35.

            "Contracts" has the meaning set forth in Section 1.2(h).

            "Dispute Accountants" has the meaning set forth in Section 2.2(d).

            "Environmental  Claim"  means any and all  claims,  demands,  suits,
actions,  orders,  directives,  notices of  noncompliance  or violation,  liens,
investigations  or  administrative,  regulatory or judicial  proceedings  by any
Person  alleging   potential   liability  or  responsibility   for  enforcement,
penalties, fines, forfeitures, damages, losses, costs, costs for Remedial Action
taken,  governmental response costs, natural resource damages, property damages,
personal injury or bodily injury arising out of, based on or resulting from: (A)
the  presence,   use,   manufacture,   processing,   distribution,   production,
generation,   handling,   transport,  storage,  disposal,  labeling,  discharge,
release, threatened release, treatment,  control or cleanup of any Environmental
Material  at any  location;  or  (B)  circumstances  forming  the  basis  of any
violation,  or alleged  violation,  of any Environmental Law; or (C) any and all
claims by any person or Governmental  Authority  seeking damages,  contribution,
indemnification,  costs,  compensation or injunctive  relief  resulting from the
presence or Environmental Release of any Environmental Material.

            "Environmental  Law" means any Legal Requirement which relates to or
otherwise  imposes  liability,  obligations,  responsibility,  or standards with
respect to zoning, land use, pollution, or the restoration,  repair, remediation
or protection of natural resources,  human health or the environment  (including
ambient air, surface water, groundwater,  land surface, subsurface soil strata),
including without  limitation,  any Legal Requirement  relating to the presence,
use, manufacture,  processing,  distribution,  production, generation, handling,
transport,  storage, disposal, labeling, discharge, release, threatened release,
treatment, control or cleanup of any Environmental Material.

            "Environmental   Material"  means:  (A)  any  petroleum   substance,
petroleum product,  underground storage tank,  underground cistern,  radioactive
material,   asbestos  in  any  form  that  is  or  could  become  friable,  urea
formaldehyde  foam  insulation,   PCB-containing  Material;  (B)  any  Hazardous
Substance, Hazardous Material, Hazardous Waste or any other material, substance,
chemical,  waste,  contaminant or pollutant which is now or hereafter defined as
or  determined  to  be  hazardous,   extremely  hazardous,   toxic,   dangerous,
restricted,  or a nuisance,  or words of similar import, under any Environmental
Law; (C) any other material, substance, chemical, waste, contaminant,  pollutant
or exposure to which is now prohibited, limited or regulated by any Governmental
Authority or pursuant to any Environmental Law.


                                      -46-


<PAGE>

            "Environmental Permits" means all permits, licenses, authorizations,
certifications,  notices,  approvals or  authorizations  under any Environmental
Law.

            "Environmental  Release"  shall mean any release,  spill,  emission,
leaking,  injection,  deposit,  disposal,  discharge,   dispersal,  leaching  or
migration into the atmosphere, soil, surface water, groundwater or soil.

            "Equipment" has the meaning set forth in Section 1.2(f).

            "ERISA" means the Employee  Retirement  Income Security Act of 1974,
as amended.

            "Estimated  Net Book  Value"  has the  meaning  set forth in Section
2.2(a).

            "Excluded Assets" has the meaning set forth in Section 1.3.

            "Excluded Liabilities" has the meaning set forth in Section 3.2.

            "Final Net Book Value" has the meaning set forth in Section 2.2(a).

            "Financial Statements" has the meaning set forth in Section 4.9.

            "First Day" has the meaning set forth in Section 7.13.

            "GAAP" means United States generally accepted accounting  principles
as in effect from time to time.

            "Granada Leases" means, collectively, that certain Lease dated as of
February 27, 1990 between the Seller and Sueldo Associates, a California general
partnership, as amended, and that certain Revised and Restated Lease dated as of
March 1, 1990  between  the Seller and  Granada  Associates,  LLC, a  California
limited liability company, as amended.

            "Governmental  Authority"  means the government of the United States
of America and any other country, and any state, province, municipality or other
governmental  unit,  or  any  court,  agency,  board,  bureau,  instrumentality,
department or commission  (including any court or other  tribunal) of any of the
foregoing.

            "Hazardous  Material" means hazardous materials as defined under the
regulations adopted pursuant to the Hazardous Materials Transportation Act. Such
regulations appear at 49 C.F.R. Part 171, et seq.

            "Hazardous  Substance"  means hazardous  substances as defined under
the  Comprehensive  Environmental  Response,  Compensation and Liability Act, 42
U.S.C. ss.9601, et seq. and under comparable state laws.

            "Hazardous  Waste"  means  hazardous  waste  as  defined  under  the
Resource Conservation and Recovery Act, 42 U.S.C.ss.6901,  et seq.ss.144.60,  et
seq. and other comparable state laws.


                                      -47-


<PAGE>

            "Hired Employees" has the meaning set forth in Section 7.8.

            "Indemnifiable Damages" has the meaning set forth in Section 10.1.

            "Indemnitees" has the meaning set forth in Section 11.1.

            "Indemnitors" has the meaning set forth in Section 10.1.

            "Insurance" has the meaning set forth in Section 4.16(a).

            "Intellectual  Property" means, with respect to any Person,  any and
all United States and foreign  intellectual  property  owned or licensed by that
Person, including, without limitation, (i) all inventions (whether patentable or
unpatentable and whether or not reduced to practice),  all improvements thereto,
and all patents, patent applications (including international applications), and
patent    disclosures,    together   with   all   reissuances,    continuations,
continuations-in-part,  revisions,  extensions, and reexaminations thereof, (ii)
all trademarks,  service marks, trade dress, logos, trade names, brand names and
corporate names (including,  without limitation,  in the case of the Seller, the
name  "JBL  Scientific"  and  all  derivatives   thereof),   together  with  all
translations,  adaptations,  derivations, and combinations thereof and including
all goodwill  associated  therewith,  and all applications,  registrations,  and
renewals in connection therewith, (iii) all copyrightable works, all copyrights,
and all applications,  registrations, and renewals in connection therewith, (iv)
all mask works and all applications,  registrations,  and renewals in connection
therewith,   (v)  all  trade  secrets  and  confidential   business  information
(including ideas, research and development,  know-how,  formulas,  compositions,
manufacturing and production processes and techniques,  technical data, designs,
drawings,  specifications,   customer  and  supplier  lists,  pricing  and  cost
information,  and business and marketing plans and proposals), (vi) all computer
software owned or licensed by the Seller specifically including, but not limited
to,  software  developed  by or for  the  Seller  (including  data  and  related
documentation),  (vii) all other  proprietary  rights,  (viii)  all  copies  and
tangible embodiments thereof (in whatever form or medium). Intellectual Property
to be assigned includes, without limitation, the Intellectual Property set forth
in the Intellectual Property Assignments.

            "Intellectual Property Assignments" means those certain Intellectual
Property Assignments dated as of the Closing Date, between the Buyer and (i) the
Seller and (ii) the Shareholder,  in substantially the forms of Exhibits C-1 and
C-2  respectively,  as  the  same  may be  amended,  restated,  supplemented  or
otherwise modified from time to time.

            "Inventories" has the meaning set forth in Section 1.2(b).

            "IRS" means the Internal Revenue Service.

            "Knowledge"  means,  with respect to the Seller and the Shareholder,
the actual knowledge of Kenneth G. Kasses,  Thomas G. Burger, Robert E. Klem and
Lauren R. Brown after due inquiry.

            "Latest  Balance  Sheet" means the  unaudited  balance sheet for the
Business dated as of the Latest Balance Sheet Date and attached in Schedule 4.9.


                                      -48-


<PAGE>

            "Latest  Balance  Sheet  Date" has the  meaning set forth in Section
4.9.

            "Latest Fiscal Year End" has the meaning set forth in Section 4.9.

            "Lease" means that certain Lease  Agreement to be entered into as of
the Closing  Date,  between the Buyer and Granada  Associates,  LLC,  containing
terms  substantially  similar to the terms set forth on Exhibit D hereto, as the
same may be amended,  restated,  supplemented or otherwise modified from time to
time in accordance with its terms.

            "Leased  Property" shall mean the Real Estate,  as well as any other
real estate heretofore owned or used by Seller in the conduct of the Business.

            "Legal  Requirement"  means  any  and  all  statutes,  laws,  codes,
ordinances,  regulations,  rules, directives,  policy, orders, judgments, writs,
injunctions, rulings, decrees, bylaws or common law (whether presently in effect
or hereinafter  enacted,  adopted,  promulgated  or issued) of any  Governmental
Authority.

            "Liability"  means any  liability or  obligation  (whether  known or
unknown, whether asserted or unasserted, whether absolute or contingent, whether
accrued or unaccrued, whether liquidated or unliquidated,  and whether due or to
become due), including, without limitation, any liability for Taxes.

            "Lien" means any  mortgage,  pledge,  lien,  encumbrance,  charge or
other security interest of any kind.

            "Lipid License Agreement" means that certain Lipid License Agreement
dated  as of the  Closing  Date,  between  the  Shareholder  and the  Buyer,  in
substantially the form of Exhibit E attached hereto, as the same may be amended,
restated,  supplemented  or otherwise  modified  from time to time in accordance
with its terms,  pursuant to which the Buyer grants to the Seller an  exclusive,
royalty free license to use technology  pertaining to cationic lipids  described
in Attachment E-1 to the Lipid License Agreement.

            "Losses" has the meaning set forth in Section 10.1(a).

            "Material  Adverse  Effect" means a material  adverse  effect on the
Purchased Assets, operations, prospects or condition (financial or otherwise) of
the Business.

            "Net Book Value" has the meaning set forth in Section 2.2(b).

            "Nondisclosure  and  Noncompetition  Agreement"  means that  certain
Consulting and Noncompetition Agreement, dated as of the Closing Date, among the
Buyer,  the Seller and the Shareholder,  in substantially  the form of Exhibit F
attached hereto, as the same may be amended, restated, supplemented or otherwise
modified from time to time.

            "Note" means that certain $1,200,000 promissory note dated as of the
Closing Date made by the Buyer in favor of the Seller in substantially  the form
of  Exhibit G hereto,  as the same may be  amended,  restated,  supplemented  or
otherwise modified from time to time.


                                      -49-


<PAGE>

            "Notice of Claim" has the meaning set forth in Section 10.2.

            "Notice of Objection" has the meaning set forth in Section 10.2.

            "On-Site Contamination" has the meaning set forth in Section 6.23.

            "Operating  Accruals"  means the Assumed  Liabilities  specified  in
Section 3.1(a).

            "Ordinary  Course of Business" means the ordinary course of business
consistent   with  past  practice   (including  with  respect  to  quantity  and
frequency).

            "Owner" has the meaning set forth in the definition of  "Subsidiary"
set forth in Section 15.1.

            "PCB-containing Material" means polychlorinated biphenyls, including
PCB-laden lubricating or hydraulic oils or transformers or other equipment which
contain dielectric fluid containing polychlorinated biphenyls.

            "Pension Plan" has the meaning set forth in Section 4.25(a).

            "Permits" has the meaning set forth in Section 1.2(i).

            "Permitted Liens" means (a) any Lien for taxes that are not yet due,
(b)  any  carrier's,  warehouseman's,  mechanic's,  materialman's,  repairman's,
landlord's,  lessor's  or similar  statutory  lien  incidental  to the  ordinary
conduct of the  Business or (c) any  municipal  and zoning  ordinance,  recorded
easement, covenant or restriction that does not prohibit or materially interfere
with the present use, or materially affect the present value, of the Business or
the Purchased Assets.

            "Person"  means an  individual,  partnership,  corporation,  limited
liability company, firm, enterprise, business trust, joint stock company, trust,
unincorporated  association,  joint  venture,  Governmental  Authority  or other
entity of whatever nature.

            "Preliminary  Purchase  Price" has the  meaning set forth in Section
2.1(a).

            "Products Liability" has the meaning set forth in Section 4.26.

            "Promega"  has the meaning set forth in the fifth  paragraph  of the
recitals to this Agreement.

            "Promega 401(k) Plan" has the meaning set forth in Section 7.12.

            "Protected  Promega  Person"  has the  meaning  set forth in Section
11.7.

            "Protected  Shareholder Person" has the meaning set forth in Section
10.7.


                                      -50-


<PAGE>

            "Purchase Price" has the meaning set forth in Section 2.2(a).

            "Purchased Assets" has the meaning set forth in Section 1.2.

            "Quality  Assurance  Agreement" means that certain Quality Assurance
and  Quality  Control  Agreement,  between  the  Buyer and the  Shareholder,  in
substantially the form of Exhibit H attached hereto, as the same may be amended,
restated, supplemented or otherwise modified from time to time.

            "Real Estate" has the meaning set forth in Section 1.2(e).

            "Receivables" has the meaning set forth in Section 1.2(c).

            "Records"  means  books  of  account,   ledgers,   forms,   records,
documents,  files,  invoices,  lab notebooks,  archived batch records,  chemical
waste disposal records, vendor or supplier lists, plans and other data which are
necessary to or desirable for the  ownership,  use,  maintenance or operation of
the  Business  and  which are owned or used by any  Seller,  including,  without
limitation,  all blueprints and  specifications,  all Tax,  personnel,  payroll,
payroll tax and labor relations  records,  all  environmental  control  records,
environmental  impact  reports,  statements,   studies  and  related  documents,
handbooks,  technical  manuals  and data,  engineering  specifications  and work
papers, all pricing and cost information,  all sales records, all accounting and
financial records,  all sales and use Tax returns,  reports,  files and records,
asset history records and files,  all data entry and accounting  systems used to
conduct the day-to-day  operations of the Business,  all  maintenance and repair
records, all correspondence, notices, citations and all other documents received
from, sent to or in the Seller's  possession in connection with any Governmental
Authority  (including,  without limitation,  federal,  state, county or regional
environmental protection, air or water quality control,  occupational health and
safety,  land  use,  planning  or  zoning  and  any  alcohol,  beverage  or fire
prevention authorities), all plans, maps and surveys of the Real Estate, and all
plans and designs of buildings, structures, fixtures and equipment.

            "Remedial  Action" means any action taken or required to be taken as
a result of Environmental Law or by demand of Governmental Authority in response
to a known or suspected  condition in the  environment  (including  ambient air,
surface water, groundwater,  land surface or subsurface soil strata), including,
without  limitation,  sampling,  investigation,   monitoring,  remedial  action,
remediation,  removal, response,  restoration,  repair, replacement,  treatment,
clean-up and corrective action.

            "Restricted Interests" has the meaning set forth in Section 1.5(a).

            "Securities  Act"  means the  Securities  Act of 1993,  as  amended,
including any rules and regulations promulgated thereunder.

            "Securities Exchange Act" means the Securities Exchange Act of 1934,
as amended, including any rules and regulations promulgated thereunder.

            "Seller"  has the meaning set forth in the first  paragraph  to this
Agreement.


                                      -51-


<PAGE>

            "Seller Indemnifiable  Damages" has the meaning set forth in Section
11.1.

            "Seller Notice of Claim" has the meaning set forth in Section 11.2.

            "Seller  Notice of  Objection"  has the meaning set forth in Section
11.2.

            "Seller Purchased Assets" has the meaning set forth in Section 1.2.

            "Seller's Accountants" has the meaning set forth in Section 2.2(d).

            "Seller's 401(k) Plan" has the meaning set forth in Section 6.25 .

            "Seller's  Group  Health  Plan" has the meaning set forth in Section
6.24.

            "Seller's Welfare Plans" has the meaning set forth in Section 6.24.

            "Shareholder"  has the meaning set forth in the first  paragraph  to
this Agreement.

            "Shareholder  Purchased Assets" has the meaning set forth in Section
1.2.

            "Subsidiary"  means,  with  respect to any Person (the  "Owner") any
corporation or other Person of which  securities or other  interests  having the
power  to elect a  majority  of that  Person's  board of  directors  of  similar
governing  body,  or  otherwise  having  the power to direct  the  business  and
policies  of  that  Person  are  held  by  the  Owner  or  one  or  more  of its
Subsidiaries.  When used without reference to a particular  Person,  Subsidiary"
means a Subsidiary of the Seller.

            "Tax"  means any  federal,  state,  local or foreign  income,  gross
receipts,  license, payroll,  employment,  excise, severance, stamp, occupation,
premium,  windfall  profits,  environmental,   customs  duties,  capital  stock,
franchise, profits, withholding, social security, unemployment, disability, real
property,  personal property, sales, use, transfer,  registration,  value added,
alternative or add-on  minimum,  estimated or other tax of any kind  whatsoever,
including any interest, penalty or addition thereto, whether disputed or not.

            "Tax  Return"  means  any  return,  declaration,  report,  claim for
refund,  or  information  return or statement  relating to Taxes,  including any
schedule or attachment thereto, and including any amendment thereof.

            "Vehicles" has the meaning set forth in Section 1.2(g).

            14.2  Interpretation.  Unless otherwise expressly provided or unless
the  context  requires  otherwise,  (a)  all  references  in this  Agreement  to
Articles,  Sections,  Schedules  and Exhibits  shall mean and refer to Articles,
Sections,  Schedules  and  Exhibits of this  Agreement;  (b) all  references  to
statutes and related  regulations  shall include all  amendments of the same and
any  successor  or  replacement  statutes and  regulations;  (c) words using the
singular or plural  number also shall  include the plural and  singular  number,
respectively;  (d) references to "hereof,"  "herein," "hereby"


                                      -52-


<PAGE>

and similar terms shall refer to this entire Agreement  (including the Schedules
and Exhibits  hereto);  and (e) references to any Person shall be deemed to mean
and include the successors and permitted assigns of such Person (or, in the case
of a Governmental  Authority,  Persons  succeeding to the relevant  functions of
such Person).

            14.3 Other Terms. Except as otherwise  specifically  provided,  each
accounting term used herein shall have the meaning given to it under GAAP.


                                   ARTICLE XV

                                  MISCELLANEOUS

            15.1  Survival  of  Representations  and  Warranties.   All  of  the
representations  and warranties of the parties contained in this Agreement shall
survive the Closing hereunder to the extent provided in Sections 10.4 and 11.4.

            15.2 Benefit and  Assignment.  This Agreement  shall be binding upon
and  inure to the  benefit  of the  parties  hereto,  their  heirs,  successors,
assignees, and beneficiaries in interest; provided, however, that this Agreement
may not be assigned by the Seller or the  Shareholder  without the prior written
consent of the Buyer.

            15.3  Governing  Law.  This  Agreement  shall  be  governed  by  and
construed  in  accordance  with  the  internal  laws of the  State  of New  York
(regardless of such State's conflict of laws principles),  and without reference
to any rules of  construction  regarding the party  responsible for the drafting
hereof.

            15.4 Expenses.  Except as otherwise  herein  provided,  all expenses
incurred in connection with this Agreement or the  transactions  herein provided
for shall be paid by the party incurring such expenses and costs.

            15.5  Notices.  Every  notice  or other  communication  required  or
contemplated  by  this  Agreement  must  be in  writing  and  sent by one of the
following methods:  (i) personal  delivery,  in which case delivery is deemed to
occur the day of delivery;  (ii) certified or registered mail,  postage prepaid,
return receipt  requested,  in which case delivery is deemed to occur the day it
is officially  recorded by the U.S.  Postal Service as delivered to the intended
recipient;  or (iii) next-day delivery to a U.S. address by recognized overnight
delivery  service such as Federal  Express,  in which case delivery is deemed to
occur one  business  day  after  being  sent.  In each  case,  a notice or other
communication sent to a party must be directed to the address for that party set
forth below, or to another address designated by that party by written notice:


                                      -53-


<PAGE>

            (a)  If to the Buyer or Promega,

                 or both:                  Promega Corporation
                                           2800 Woods Hollow Road
                                           Madison, WI  53711-5399
                                           Attn:  General Counsel

                 With a copy to:           Tod B. Linstroth, Esq.

                                           Michael Best & Friedrich LLP
                                           One South Pinckney Street
                                           Suite 700
                                           Madison, WI 53703

            (b)  If to the Seller or the
                 Shareholder, or both:     c/o Genta Incorporated
                                           One Ledgemont Center
                                           99 Hayden Avenue, Suite 200
                                           Lexington, MA 02421
                                           Attn:  Kenneth G. Kasses, Ph.D.

                 With a copy to:           Monica Lord, Esq.
                                           Kramer Levin Naftalis & Frankel LLP
                                           919 Third Avenue
                                           New York, NY 10022

            15.6 Counterparts.  This Agreement may be executed simultaneously in
two or more counterparts,  each of which shall be deemed an original, but all of
which together shall constitute one and the same  instrument,  provided that all
such counterparts, in the aggregate, shall contain the signatures of all parties
hereto.

            15.7  Headings.   All  Section  headings  herein  are  inserted  for
convenience   only  and  shall  not  modify  or  affect  the   construction   or
interpretation of any provision of this Agreement.

            15.8 Amendment,  Modification and Waiver.  This Agreement may not be
modified,  amended or supplemented except by mutual written agreement of all the
parties hereto.  Any party may waive in writing any term or condition  contained
in this Agreement and intended to be for its benefit; provided, however, that no
waiver  by any  party,  whether  by  conduct  or  otherwise,  in any one or more
instances, shall be deemed or construed as a further or continuing waiver of any
such term or condition. Each amendment, modification, supplement or waiver shall
be in writing signed by the party or the parties to be charged.

            15.9 Entire Agreement. This Agreement and the Exhibits and Schedules
attached  hereto  represent the full and complete  agreement of the parties with
respect  to the  subject  matter  hereof and  supersede  and  replace  any prior
understandings  and  agreements  among the parties  with  respect to the subject
matter  hereof and no  provision or document of any kind shall be included in or
form a part of such agreement  unless signed and delivered to the other party by
the parties to be charged.


                                      -54-


<PAGE>

            15.10  Third-Party  Beneficiaries.  No third parties are intended to
benefit from this  Agreement,  and no  third-party  beneficiary  rights shall be
implied from anything  contained in this  Agreement,  except that each Protected
Shareholder   Person  and  each  Protected   Promega  Person  is  a  third-party
beneficiary under Sections 10.7 and 11.7, respectively.

            15.11  Publicity.  The Buyer and the Seller  agree that no publicity
announcements  or disclosures of any kind concerning the terms of this Agreement
or concerning  the  transactions  contemplated  hereby shall be made without the
mutual consent of the Buyer and the Seller, except to the extent that disclosure
is  required  by law or to  accountants,  counsel,  other  professionals  and to
lenders  on a  "need  to  know"  basis  who  similarly  agree  to  maintain  the
confidentiality  of  the  existence  of  and  terms  of the  Agreement  and  the
transactions contemplated thereby.

            15.12 Specific  Performance.  Each of the Buyer, Promega, the Seller
and the  Shareholder  acknowledges  and agrees that the other  parties  would be
damaged irreparably in the event any of the provisions of this Agreement are not
performed in  accordance  with their  specific  terms or otherwise are breached.
Accordingly,  each of the Buyer,  Promega, the Seller and the Shareholder agrees
that the other  parties shall be entitled to an  injunction  or  injunctions  to
prevent  breaches of the  provisions of this  Agreement and all  agreements  and
transactions contemplated hereby, and to enforce specifically this Agreement and
all  agreements  and  transactions   contemplated  hereby,  and  the  terms  and
provisions hereof or thereof in any action instituted in any court of the United
States or any state thereof having jurisdiction over the parties and the matter,
in  addition  to any  other  remedy  to which it may be  entitled,  at law or in
equity.

                            [SIGNATURE PAGE FOLLOWS]


                                      -55-


<PAGE>

                  [Signature Page to Asset Purchase Agreement]

            IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be executed as of the date and year first above written.

                                              JBL ACQUISITION CORP.

                                              By:_______________________________
                                              Its:______________________________

                                              JBL SCIENTIFIC INCORPORATED

                                              By:_______________________________
                                              Its:______________________________

                                              GENTA INCORPORATED

                                              By:_______________________________
                                              Its:______________________________

            Promega  Corporation  hereby  executes this Agreement to confirm its
obligations under Section 13.2 of this Agreement.

                                              PROMEGA CORPORATION

                                              By:_______________________________
                                              Its:______________________________


<PAGE>

                                   EXHIBIT A-1

         [Form of Legal Opinion of Kramer Levin Naftalis & Frankel LLP]



                                      A-1-1


<PAGE>


                                   EXHIBIT A-2

          [Form of Legal Opinion of Sinsheimer, Schiebelhut & Baggett]


                                      A-2-1


<PAGE>

                                   EXHIBIT A-3

             [Form of Legal Opinion of Michael Best & Friedrich LLP]




                                      A-3-1

<PAGE>

                                    EXHIBIT B

           [Form of Assignment, Bill of Sale and Assumption Agreement]



                                       B-1



<PAGE>

                                   EXHIBIT C-1

                [Form of Seller Intellectual Property Assignment]




                                      C-1-1


<PAGE>

                                   EXHIBIT C-2

             [Form of Shareholder Intellectual Property Assignment]




                                      C-2-1


<PAGE>

                                    EXHIBIT D

                            [Summary of Lease Terms]

                                       D-1


<PAGE>

                                    EXHIBIT E

                        [Form of Lipid License Agreement]



                                       E-1



<PAGE>

                                    EXHIBIT F

              [Form of Nondisclosure and Noncompetition Agreement]




                                       F-1


<PAGE>

                                    EXHIBIT G

                                 [Form of Note]



                                       G-1



<PAGE>

                                    EXHIBIT H

                      [Form of Quality Assurance Agreement]



                                       H-1


<TABLE> <S> <C>


<ARTICLE>                     5
<LEGEND>
     This schedule  contains summary  financial  information  extracted from the
consolidated balance sheets and consolidated  statements of operations contained
in the  Company's  Quarterly  Report on Form 10-Q for the period ended March 31,
1999 and is qualified in its entirety by reference to such financial statements.
</LEGEND>

       
<S>                             <C>                   <C>
<PERIOD-TYPE>                   3-MOS                 3-MOS
<FISCAL-YEAR-END>                   DEC-31-1998           DEC-31-1999 
<PERIOD-START>                      JAN-01-1998           JAN-01-1999 
<PERIOD-END>                        MAR-31-1998           MAR-31-1999 
<CASH>                                1,566,288               638,990 
<SECURITIES>                            892,372                     0 
<RECEIVABLES>                                 0               261,000 
<ALLOWANCES>                                  0                     0 
<INVENTORY>                                   0                     0 
<CURRENT-ASSETS>                      5,937,364             4,051,843 
<PP&E>                                  148,245                27,799
<DEPRECIATION>                                0                     0
<TOTAL-ASSETS>                        7,551,293             5,446,967
<CURRENT-LIABILITIES>                 2,308,256             2,486,862
<BONDS>                                       0                     0
                         0                     0
                                 634                   574
<COMMON>                                 10,426                15,030
<OTHER-SE>                            5,231,977             2,944,501
<TOTAL-LIABILITY-AND-EQUITY>          7,551,293             5,446,967
<SALES>                                       0                     0
<TOTAL-REVENUES>                              0                     0
<CGS>                                         0                     0
<TOTAL-COSTS>                         1,792,018             2,202,378
<OTHER-EXPENSES>                              0               149,114
<LOSS-PROVISION>                              0                     0
<INTEREST-EXPENSE>                      (82,337)              (51,691)
<INCOME-PRETAX>                               0                     0
<INCOME-TAX>                                  0                     0
<INCOME-CONTINUING>                  (1,865,425)              (15,783)
<DISCONTINUED>                          103,060              (189,407)
<EXTRAORDINARY>                               0                     0
<CHANGES>                                     0                     0
<NET-INCOME>                         (1,762,365)             (547,599)
<EPS-PRIMARY>                            (0.31)                (0.04)
<EPS-DILUTED>                            (0.31)                (0.04)
                                      


</TABLE>


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