GENTA INCORPORATED /DE/
S-3/A, EX-5.1, 2000-08-10
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                                                     Exhibit 5.1


                       KRAMER LEVIN NAFTALIS & FRANKEL LLP
                                919 THIRD AVENUE
                           NEW YORK, N.Y. 10022 - 3852


   TEL (212) 715-9100                                          47, Avenue Hoche
   FAX (212) 715-8000                                             75008 Paris
                                                                    France


                                           August 10, 2000


Genta Incorporated
99 Hayden Avenue, Suite 200
Lexington, Massachusetts  02421

Ladies and Gentlemen:

                  We  are  rendering   this  opinion  in  connection   with  the
Registration  Statement  on Form S-3 (File  No.  333-40634)  (the  "Registration
Statement") filed by Genta Incorporated, a Delaware corporation (the "Company"),
with the Securities and Exchange Commission under the Securities Act of 1933, as
amended.  The  Registration  Statement  relates  to up to  382,787  shares  (the
"Registered  Shares") of the Company's  common stock, par value $0.001 per share
("Common Stock"). We understand that the Registered Shares are to be offered and
sold in the manner described in the Registration Statement.

                  We  have  acted  as  your  counsel  in  connection   with  the
preparation of the Registration  Statement.  We have made such legal and factual
examinations and inquiries and examined such corporate records, certificates and
other documents as we have considered  necessary or appropriate for the purposes
of this  opinion.  In  rendering  this  opinion,  we have  (a)  assumed  (i) the
genuineness  of all  signatures  on all  documents  examined  by  us,  (ii)  the
authenticity  of all  documents  submitted  to us as  originals  and  (iii)  the
conformity to original documents of all documents submitted to us as photostatic
or conformed  copies and the  authenticity of the originals of such copies;  and
(b) relied on (i)  certificates  of public  officials  and (ii) as to matters of
fact,   representations,   statements   and   certificates   of   officers   and
representatives  of the Company.  In giving the opinion set forth below, we give
no assurance that certain of the Registered  Shares will not be forfeited to the
Company pursuant to an agreement pursuant to which such shares were issued.

                  Based  upon  the  foregoing,  we are of the  opinion  that the
Registered  Shares have been duly  authorized and are validly issued and, to the
extent not forfeited, are fully paid and non-assessable.

                  We are attorneys admitted to the Bar of the State of New York,
and we do not  express  any  opinion  as to any  laws  other  than  the  General
Corporation Law of the State of Delaware.

<PAGE>

Genta Incorporated
August 10, 2000
Page 2


                  We hereby  consent to the filing of this  opinion as a part of
the  Registration  Statement  and to the reference to our firm under the caption
"Legal Matters" in the Prospectus filed as part thereof.  In giving such consent
we do not  thereby  concede  that we are within the  category  of persons  whose
consent is required  under Section 7 of the  Securities Act of 1933, as amended,
or the rules and regulations promulgated thereunder.

                                     Very truly yours,

                                     /s/ Kramer Levin Naftalis & Frankel LLP




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