SCICLONE PHARMACEUTICALS INC
S-8, 1996-09-17
PHARMACEUTICAL PREPARATIONS
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As filed with the Securities and Exchange Commission on September 17, 1996
                                                 Registration No. 33-__________
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                ----------------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                         SCICLONE PHARMACEUTICALS, INC.
             (Exact name of Registrant as specified in its charter)

                 CALIFORNIA                                 94-3116852
(State or other jurisdiction of incorporation            (I.R.S. employer
              or organization)                          identification no.)

                          901 Mariners Island Boulevard
                               San Mateo, CA 94404
                    (Address of principal executive offices)

                             -----------------------

                        1996 EMPLOYEE STOCK PURCHASE PLAN
                            (Full title of the Plan)

                             -----------------------

                                 Mark A. Culhane
                   Vice President, Finance and Administration
                         SciClone Pharmaceuticals, Inc.
                          901 Mariners Island Boulevard
                               San Mateo, CA 94404
                                 (415) 358-3456
 (Name, address and telephone number, including area code, of agent for service)
 
                             -----------------------

                                    Copy to:

                               Joshua Pickus, Esq.
                                Venture Law Group
                               2800 Sand Hill Road
                          Menlo Park, California 94025
                                 (415) 854-4488

<TABLE>
========================================================================================================
                         CALCULATION OF REGISTRATION FEE
========================================================================================================
<CAPTION>
                                             Proposed Maximum     Proposed Maximum
 Title of Securities to be   Amount to be   Offering Price Per   Aggregate Offering        Amount of
        Registered            Registered          Share (1)            Price (1)        Registration Fee
- --------------------------------------------------------------------------------------------------------

<S>                            <C>             <C>                   <C>                  <C>
Common Stock, no par value     500,000         $9.9375               $4,968,750           $1,714

- --------------------------------------------------------------------------------------------------------

<FN>
(1)     Estimated  solely for the purpose of calculating the registration fee in
        accordance  with Rules  457(h) and 457(c)  under the  Securities  Act of
        1933,  based  upon the  average of the high and low prices of the Common
        Stock as reported on The Nasdaq National Market on September 13, 1996.
</FN>
</TABLE>


<PAGE>


                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.           Incorporation of Documents by Reference.

         The  following   documents  filed  with  the  Securities  and  Exchange
Commission (the "Commission") are hereby incorporated by reference:

         (a)      The  Registrant's  latest  annual  report  filed  pursuant  to
Section  13(a)  or  15(d)  of the Securities Exchange  Act  of  1934, as amended
(the "Exchange Act");

         (b)      All  other reports filed pursuant to Section 13(a) or 15(d) of
the Exchange  Act since the end of the fiscal year covered by the annual  report
referred to in (a) above; and

         (c)      The  description of the Registrant's Common Stock contained in
the  Registrant's  Registration  Statement on Form 8-A filed with the Commission
under  Section  12 of the  Exchange  Act on  January  31,  1992,  including  any
amendment or report filed for the purpose of updating such description.

         All documents subsequently filed by the Registrant pursuant to Sections
13(a),  13(c),  14 and  15(d) of the  Exchange  Act,  prior to the  filing  of a
post-effective amendment which indicates that all securities offered hereby have
been sold or which  deregisters all securities then remaining  unsold,  shall be
deemed to be incorporated by reference in this Registration  Statement and to be
part hereof from the date of filing such documents.

Item 4.           Description of Securities.  Not applicable.

Item 5.           Interests of Named Experts and Counsel.  Not applicable.

Item 6.           Indemnification of Directors and Officers.

         The  Company's  Restated  Articles of  Incorporation  provide  that the
liability of the  directors  for monetary  damages  shall be  eliminated  to the
fullest extent permissible under California law. Pursuant to California law, the
Company's  directors shall not be liable for monetary  damages for breach of the
directors' fiduciary duty of care to the Company and its shareholders.  However,
this provision in the Restated Articles of Incorporation  does not eliminate the
duty of  care,  and in  appropriate  circumstances  equitable  remedies  such as
injunctive  or other forms of  nonmonetary  relief will remain  available  under
California  law.  In  addition,  each  director  will  continue to be subject to
liability  (i) for acts or omissions  that involve  intentional  misconduct or a
knowing  and  culpable  violation  of law,  (ii)  for acts or  omissions  that a
director  believes to be contrary  to the best  interests  of the Company or its
shareholders  or that  involve  the  absence  of good  faith  on the part of the
director,  (iii) for any transaction  from which a director  derived an improper
personal benefit,  (iv) for acts or omissions that show a reckless disregard for
the director's duty to the Company or its shareholders in circumstances in which
the director  was aware,  or should have been aware,  in the ordinary  course of
performing a director's duties, of a risk of serious injury to

                                      II-1

<PAGE>


the Company or its  shareholders,  (v) for acts or omissions  that constitute an
unexcused pattern of inattention that amounts to an abdication of the director's
duty  to  the  Company  or its  shareholders,  (vi)  for  any  transaction  that
constitutes an illegal  distribution or dividend under California law, and (vii)
for any  transaction  involving  an unlawful  conflict  of interest  between the
director  and the Company  under  California  law. The  provision  also does not
affect a director's  responsibilities  under any other law,  such as the federal
securities laws or state or federal environmental laws.

         In addition,  the Company's Restated Articles of Incorporation  provide
that the Company is authorized to provide  indemnification of agents (as defined
under  California  law) for breach of duty to the Company  and its  shareholders
through bylaw  provisions,  agreements with the agents,  vote of shareholders or
disinterested directors or otherwise, in excess of the indemnification otherwise
permitted   by   California   law,   subject  to  the  limits  on  such   excess
indemnification set forth in California law.

         The  Company's  Bylaws  provide  that the Company  will  indemnify  its
directors  and  officers to the maximum  extent and in the manner  permitted  by
California  law and may  indemnify its employees and other agents to the maximum
extent and in the manner  permitted by California law. Such  indemnification  is
intended to provide the full flexibility available under California law and may,
under certain  circumstances,  include  indemnification  for  negligence,  gross
negligence  and certain  types of  recklessness.  Under  California  law and the
Company's  Bylaws,  the Company will be permitted  to indemnify  its  directors,
officers,  employees and other agents,  within the limits established by law and
public policy,  pursuant to an express  contract,  bylaw provision,  shareholder
vote or  otherwise,  any or all of which could  provide  indemnification  rights
broader than those  expressly  available  under  California law. The Company has
entered  into  agreements  with  its  directors  and  certain  of its  officers,
including all of its executive  officers,  that require the Company to indemnify
such persons against expenses,  judgments,  fines, settlements and other amounts
actually and reasonably  incurred (including expenses of a derivative action) in
connection with any proceeding,  whether actual or threatened, to which any such
person  may be made a party by reason  of the fact that such  person is or was a
director  or an officer of the  Company  or any of its  affiliated  enterprises,
provided such person acted in good faith and in a manner such person  reasonably
believed to be in or not opposed to the best  interests of the Company and, with
respect to any criminal  proceeding,  had no reasonable  cause to believe his or
her conduct was unlawful. The indemnification  agreements also set forth certain
procedures  that  will  apply  in  the  event  of a  claim  for  indemnification
thereunder.

Item 7.           Exemption from Registration Claimed.  Not applicable.

                                      II-2


<PAGE>


Item 8.     Exhibits.

               Exhibit
               Number
               ------

                 4.1    1996 Employee Stock  Purchase  Plan and related forms of
                        Agreement
                 5.1    Opinion of Venture Law Group.
                24.1    Consent of Venture Law Group (included in Exhibit 5.1).
                24.2    Consent of Ernst & Young LLP, Independent  Auditors (see
                        p. II-7).
                25.1    Power of Attorney (see p. II-6).

Item 9.     Undertakings.

         The undersigned Registrant hereby undertakes:

                          (1) to file,  during  any  period  in which  offers or
         sales are being made, a post-effective  amendment to this  registration
         statement to include any material  information with respect to the plan
         of distribution not previously disclosed in the registration  statement
         or  any  material  change  to  such  information  in  the  registration
         statement.

                          (2) that,  for purposes of  determining  any liability
         under the Securities Act of 1933,  each such  post-effective  amendment
         shall be  deemed to be a new  registration  statement  relating  to the
         securities offered therein, and the offering of such securities at that
         time shall be deemed to be the initial bona fide offering thereof.

                          (3)  to  remove  from   registration  by  means  of  a
         post-effective  amendment any of the securities  being registered which
         remain unsold at the termination of the offering.

         The  undersigned  Registrant  hereby  undertakes  that, for purposes of
determining  any liability  under the Securities Act of 1933, each filing of the
Registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange  Act of  1934  that is  incorporated  by  reference  in the
registration  statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         Insofar  as the  indemnification  for  liabilities  arising  under  the
Securities Act of 1933 may be permitted to directors,  officers and  controlling
persons of the Registrant pursuant to the foregoing  provisions,  the Registrant
has been advised that in the opinion of the Securities  and Exchange  Commission
such indemnification is against public policy as expressed in the Securities Act
of

                                      II-3

<PAGE>


1933  and  is,  therefore,   unenforceable.  In  the  event  that  a  claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
Registrant of expenses  incurred or paid by a director,  officer or  controlling
person  of the  Registrant  in a  successful  defense  of any  action,  suit  or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered hereunder,  the Registrant will,
unless in the opinion of its counsel the  question  has already  been settled by
controlling  precedent,  submit  to a  court  of  appropriate  jurisdiction  the
question  of whether  such  indemnification  by it is against  public  policy as
expressed  in the  Securities  Act of 1933 and  will be  governed  by the  final
adjudication of such issue.


                                      II-4

<PAGE>



                                   SIGNATURES


         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the City of San Mateo, State of California,  on this 17th day of
September, 1996.

                                       SCICLONE PHARMACEUTICALS, INC.

                                       By: DONALD R. SELLERS
                                           ---------------------------------
                                           Donald R. Sellers
                                           President and Chief Executive Officer


                                      II-5

<PAGE>


                                POWER OF ATTORNEY


         Each person whose  signature  appears  below  constitutes  and appoints
Donald R. Sellers and Mark A. Culhane,  and each of them, as  attorneys-in-fact,
each with the power of substitution,  for him in any and all capacities, to sign
any amendment to this registration statement and to file the same, with exhibits
thereto and other  documents in connection  therewith,  with the  Securities and
Exchange Commission, granting to said attorneys-in-fact,  and each of them, full
power and authority to do and perform each and every act and thing requisite and
necessary  to be done in  connection  therewith,  as  fully to all  intents  and
purposes as he might or could do in person,  hereby ratifying and confirming all
that  said  attorneys-in-fact  or any of them,  or their  or his  substitute  or
substitutes, may lawfully do or cause to be done by virtue hereof.

<TABLE>
         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.


<CAPTION>
                Signature                                 Title                                       Date
- ------------------------------------    ------------------------------------------             ------------------

<S>                                      <C>                                                   <C>
DONALD R. SELLERS                        Chief Executive Officer and Director                  September 17, 1996
- ------------------------------------      (Principal Executive Officer)
(Donald R. Sellers)                       

MARK A. CULHANE                          Vice President, Finance and                           September 17, 1996
- ------------------------------------      Administration, Chief Financial
(Mark A. Culhane)                         Officer and Secretary (Principal 
                                          Financial and Accounting Officer)

THOMAS E. MOORE                          Chairman of the Board of Directors                    September 17, 1996
- ------------------------------------
(Thomas E. Moore)


JOHN D. BAXTER, M.D.                     Director                                              September 17, 1996
- ------------------------------------
(John D. Baxter, M.D.)


EDWIN C. CADMAN, M.D.                    Director                                              September 17, 1996
- ------------------------------------
(Edwin C. Cadman, M.D.)


JERE E. GOYAN, PH.D.                     Director                                              September 17, 1996
- ------------------------------------
(Jere E. Goyan, Ph.D.)
</TABLE>


                                      II-6


<PAGE>


               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the incorporation by reference in the Registration Statement (Form
S-8)   pertaining  to  the  1996  Employee   Stock  Purchase  Plan  of  SciClone
Pharmaceuticals,  Inc. of our report dated January 18, 1996, with respect to the
consolidated financial statements of SciClone Pharmaceuticals, Inc., included in
its Annual  Report  (Form 10-K) for the year ended  December 31, 1995 filed with
the Securities and Exchange Commission.



Palo Alto, California
September 16, 1996

                                      II-7


<PAGE>


<TABLE>
                                INDEX TO EXHIBITS


<CAPTION>
  Exhibit                                                                   Sequential Page
  Number   Description                                                      No.
  ------   -----------                                                      ---

   <S>     <C>
    4.1    1996 Employee Stock Purchase Plan and related forms of
           Agreement
    5.1    Opinion of Venture Law Group.
   24.1    Consent of Venture Law Group (included in Exhibit 5.1).
   24.2    Consent of Ernst & Young LLP, Independent Auditors (see p.
           II-7).
   25.1    Power of Attorney (see p. II-6).
</TABLE>






                         SCICLONE PHARMACEUTICALS, INC.

                        1996 EMPLOYEE STOCK PURCHASE PLAN
                           (As Amended July 25, 1996)



         The following  constitute  the  provisions  of the 1996 Employee  Stock
Purchase Plan of SciClone Pharmaceuticals, Inc..

         1.  Purpose.  The  purpose of the Plan is to provide  employees  of the
Company and its Designated  Subsidiaries  with an opportunity to purchase Common
Stock  of the  Company.  It is the  intention  of the  Company  to have the Plan
qualify as an "Employee  Stock  Purchase Plan" under Section 423 of the Internal
Revenue Code of 1986, as amended. The provisions of the Plan shall, accordingly,
be construed so as to extend and limit participation in a manner consistent with
the requirements of that section of the Code.

         2.       Definitions.

                  (a) "Board" shall mean the Board of Directors of  the Company.

                  (b) "Code" shall mean the Internal Revenue  Code  of  1986, as
amended.

                  (c) "Common Stock" shall mean the Common Stock of the Company.

                  (d) "Company" shall mean  SciClone  Pharmaceuticals,  Inc.,  a
California corporation.

                  (e) "Compensation"  shall mean all regular straight time gross
earnings,  overtime  and  shift  premium  and  shall not  include  payments  for
incentive  compensation,  incentive  payments,  bonuses,  commissions  and other
compensation.

                  (f) "Continuous  Status as an Employee" shall mean the absence
of any interruption or termination of service as an Employee.  Continuous Status
as an Employee  shall not be  considered  interrupted  in the case of a leave of
absence  agreed to in writing by the Company,  provided that such leave is for a
period  of not more than 90 days or  reemployment  upon the  expiration  of such
leave is guaranteed by contract or statute.

                  (g)  "Contributions" shall mean all  amounts  credited  to the
account  of a  participant pursuant to the Plan.

                  (h)  "Designated  Subsidiaries"  shall  mean the  Subsidiaries
which have been designated by the Board from time to time in its sole discretion
as eligible to participate in the Plan.

                  (i)  "Employee"  shall mean any person,  including an Officer,
who is  customarily  employed  for at least  twenty (20) hours per week and more
than five (5) months in a calendar year by the Company or one of its  Designated
Subsidiaries.


<PAGE>


                  (j)  "Exchange Act" shall mean the Securities Exchange  Act of
1934, as amended.

                  (k)  "Purchase Date" shall mean the last day of each  Purchase
Period of the Plan.

                  (l) "Offering  Date" shall mean the first business day of each
Offering  Period  of the  Plan,  except  that in the case of an  individual  who
becomes  eligible after the first business day of an Offering  Period,  the term
"Offering  Date"  shall  mean the  first  business  day of the  Purchase  Period
coinciding with or next  succeeding the day on which that individual  becomes an
eligible Employee.
                      Options  granted  after  the  first  business  day  of  an
Offering  Period will be subject to the same terms as the options granted on the
first  business  day of such  Offering  Period  except  that  they  will  have a
different  grant date  (thus,  potentially,  a  different  exercise  price) and,
because  they  expire  at the same  time as the  options  granted  on the  first
business day of such Offering Period, a shorter term.

                  (m) "Offering  Period" shall mean a period of twenty-four (24)
months  commencing  on August 1 of every second year  commencing  August 1, 1996
(i.e.,  the second Offering  Period will commence on August 1, 1998),  except as
otherwise determined under Section 11.

                  (n)  "Officer"  shall  mean a person  who is an officer of the
Company  within the meaning of Section 16 of the  Exchange Act and the rules and
regulations promulgated thereunder.

                  (o)  "Plan"  shall mean this Employee Stock Purchase Plan.

                  (p)  "Purchase Period" shall mean a period of three (3) months
within an Offering Period.

                  (q)  "Subsidiary"  shall  mean  a  corporation,   domestic  or
foreign, of which not less than 50% of the voting shares are held by the Company
or a  Subsidiary,  whether or not such  corporation  now exists or is  hereafter
organized or acquired by the Company or a Subsidiary.

         3.       Eligibility.

                  (a) Any person who is an Employee as of the Offering Date of a
given Offering  Period shall be eligible to participate in such Offering  Period
under the Plan,  subject to the requirements of Section 5(a) and the limitations
imposed by Section 423(b) of the Code.

                  (b)   Any   provisions   of   the   Plan   to   the   contrary
notwithstanding,  no Employee  shall be granted an option under the Plan (i) if,
immediately  after the grant,  such  Employee  (or any other  person whose stock
would be  attributed to such  Employee  pursuant to Section  424(d) of the Code)
would own stock and/or hold  outstanding  options to purchase  stock  possessing
five  percent  (5%) or more of the total  combined  voting power or value of all
classes of stock of the Company or of any subsidiary of the Company,  or (ii) if
such option would permit his or her rights to purchase  stock under all employee
stock purchase plans (described in Section 423 of the

                                      -2-


<PAGE>


Code) of the  Company  and its  Subsidiaries  to accrue at a rate which  exceeds
Twenty-Five  Thousand  Dollars  ($25,000)  of fair  market  value of such  stock
(determined  at the time such option is granted) for each calendar year in which
such option is outstanding at any time.

         4.       Offering Periods and Purchase Periods.

                  (a)  Offering  Periods.  The Plan  shall be  implemented  by a
series of  Offering  Periods  of  twenty-four  (24)  months  duration,  with new
Offering  Periods  commencing on or about August 1 of  alternating  years (or at
such other time or times as may be  determined by the Board of  Directors).  The
first  Offering  Period shall commence on August 1, 1996 and continue until July
31, 1998. The Plan shall continue until terminated in accordance with Section 19
hereof. The Board of Directors of the Company shall have the power to change the
duration  and/or  the  frequency  of  Offering  Periods  with  respect to future
offerings  without  shareholder  approval if such change is  announced  at least
fifteen (15) days prior to the scheduled  beginning of the first Offering Period
to be affected.

                  (b) Purchase  Periods.  Each Offering  Period shall consist of
eight (8) consecutive  purchase periods of three (3) months  duration.  The last
day of each  Purchase  Period  shall be the  "Purchase  Date" for such  Purchase
Period.  A Purchase Period  commencing on August 1 shall end on the next October
31. A Purchase Period commencing on November 1 shall end on the next January 31.
A Purchase  Period  commencing  on  February 1 shall end on the next April 30. A
Purchase  Period  commencing  on May 1 shall end on the next July 31.  The first
Purchase  Period  shall  commence on August 1, 1996 and shall end on October 31,
1996.  The Board of Directors of the Company  shall have the power to change the
duration and/or  frequency of Purchase  Periods with respect to future purchases
without  shareholder  approval if such change is announced at least fifteen (15)
days  prior to the  scheduled  beginning  of the  first  Purchase  Period  to be
affected.

         5.       Participation.

                  (a) An eligible  Employee may become a participant in the Plan
by completing a  subscription  agreement on the form provided by the Company and
filing it with the Company's  payroll  office prior to the  applicable  Offering
Date,  unless a later time for filing the  subscription  agreement is set by the
Board  for  all  eligible  Employees  with  respect  to a  given  offering.  The
subscription  agreement  shall  set forth the  percentage  of the  participant's
Compensation  (which shall be not less than 1% and not more than 15%) to be paid
as Contributions pursuant to the Plan.

                  (b) Payroll  deductions  shall  commence on the first  payroll
following  the Offering  Date and shall end on the last payroll paid on or prior
to the last  Purchase  Period of the Offering  Period to which the  subscription
agreement is applicable, unless sooner terminated by the participant as provided
in Section 10.

         6.       Method of Payment of Contributions.

                                      -3-

<PAGE>


                  (a) The  participant  shall elect to have  payroll  deductions
made on each payday  during the  Offering  Period in an amount not less than one
percent  (1%) and not more  than  fifteen  percent  (15%) of such  participant's
Compensation on each such payday.  All payroll  deductions made by a participant
shall be credited to his or her account  under the Plan. A  participant  may not
make any additional payments into such account.

                  (b) A participant may discontinue his or her  participation in
the Plan as provided in Section 10, or, on one occasion only during each six (6)
month period during an Offering Period, may increase or decrease the rate of his
or her  Contributions  during the Offering  Period by completing and filing with
the Company a new subscription agreement.  The change in rate shall be effective
as of the beginning of the next calendar  month  following the date of filing of
the new  subscription  agreement,  if the  agreement  is filed at least ten (10)
business  days prior to such date and, if not, as of the  beginning  of the next
succeeding calendar month.

                  (c) Notwithstanding the foregoing,  to the extent necessary to
comply  with  Section   423(b)(8)  of  the  Code  and  Section  3(b)  herein,  a
participant's  payroll deductions may be decreased to 0% at such time during any
Offering Period which is scheduled to end during the current  calendar year that
the  aggregate  of all  payroll  deductions  accumulated  with  respect  to such
Offering  Period and any other  Offering  Period ending within the same calendar
year equal $21,250. Payroll deductions shall re-commence at the rate provided in
such participant's subscription Agreement at the beginning of the first Offering
Period  which  is  scheduled  to end  in the  following  calendar  year,  unless
terminated by the participant as provided in Section 10.

         7.       Grant of Option.

                  (a) On  the  Offering  Date  of  each  Offering  Period,  each
eligible  Employee  participating  in such  Offering  Period shall be granted an
option to purchase  on each  Purchase  Date a number of shares of the  Company's
Common Stock  determined by dividing such Employee's  Contributions  accumulated
prior to such Purchase Date and retained in the participant's  account as of the
Purchase Date by the lower of (i)  eighty-five  percent (85%) of the fair market
value of a share of the  Company's  Common Stock on the Offering  Date,  or (ii)
eighty-five  percent  (85%) of the fair market value of a share of the Company's
Common Stock on the Purchase Date; provided however,  that the maximum number of
shares an Employee may purchase during each calendar year for which an option is
outstanding  shall be determined at the Offering Date by dividing $25,000 by the
fair market value of a share of the Company's Common Stock on the Offering Date,
and provided  further that such purchase shall be subject to the limitations set
forth in Sections 3(b) and 13. The fair market value of a share of the Company's
Common Stock shall be determined as provided in Section 7(b).

                  (b) The  option  price per share of the  shares  offered  in a
given Offering Period shall be the lower of: (i) 85% of the fair market value of
a share of the Common Stock of the Company on the Offering  Date; or (ii) 85% of
the fair  market  value of a share of the  Common  Stock of the  Company  on the
Purchase  Date.  The fair market value of the Company's  Common Stock on a given
date shall be  determined  by the Board in its  discretion  based on the closing
price of the Common  Stock for such date (or, in the event that the Common Stock
is not traded on such date,  on the  immediately  preceding  trading  date),  as
reported by the National Association of

                                      -4-

<PAGE>


Securities  Dealers  Automated  Quotation  (Nasdaq)  National Market or, if such
price is not  reported,  the mean of the bid and asked  prices  per share of the
Common  Stock as reported by Nasdaq or, in the event the Common  Stock is listed
on a stock exchange,  the fair market value per share shall be the closing price
on such  exchange  on such date (or,  in the event that the Common  Stock is not
traded on such date, on the immediately  preceding trading date), as reported in
The Wall Street Journal.

         8. Exercise of Option.  Unless a participant withdraws from the Plan as
provided in  paragraph  10, his or her option for the purchase of shares will be
exercised  automatically  on each Purchase Date of an Offering  Period,  and the
maximum  number of full shares  subject to the option will be  purchased  at the
applicable  option  price  with  the  accumulated  Contributions  in  his or her
account.  The shares  purchased  upon exercise of an option  hereunder  shall be
deemed to be transferred to the participant on the Purchase Date.  During his or
her lifetime, a participant's option to purchase shares hereunder is exercisable
only by him or her.

         9.  Delivery.  As promptly as  practicable  after each Purchase Date of
each  Offering   Period,   the  Company  shall  arrange  the  delivery  to  each
participant,  as appropriate, of a certificate representing the shares purchased
upon  exercise of his or her option or the deposit of such number of shares with
the broker selected by the Company for  administration  of Plan stock purchases,
as  determined  by  the  Company.   Any  cash  remaining  to  the  credit  of  a
participant's account under the Plan after a purchase by him or her of shares at
the  termination  of each  Purchase  Period,  shall be carried  over to the next
Purchase Period if the Employee  continues to participate in the Plan, or if the
Employee  does  not  continue  to   participate,   shall  be  returned  to  said
participant.

         10.      Voluntary Withdrawal; Termination of Employment.

                  (a) A  participant  may withdraw all but not less than all the
Contributions credited to his or her account under the Plan at any time prior to
each  Purchase  Date  by  giving  written  notice  to  the  Company.  All of the
participant's  Contributions  credited to his or her account will be paid to him
or her promptly  after receipt of his or her notice of withdrawal and his or her
option for the current period will be automatically  terminated,  and no further
Contributions  for the  purchase  of shares  will be made  during  the  Offering
Period.

                  (b) Upon termination of the participant's Continuous Status as
an Employee  prior to the  Purchase  Date of an Offering  Period for any reason,
including retirement or death, the Contributions  credited to his or her account
will be  returned  to him or her or,  in the  case of his or her  death,  to the
person or persons  entitled thereto under Section 14, and his or her option will
be automatically terminated.

                  (c) In the event an  Employee  fails to  remain in  Continuous
Status as an Employee  of the  Company  for at least  twenty (20) hours per week
during the  Offering  Period in which the employee is a  participant,  he or she
will be deemed to have elected to withdraw  from the Plan and the  Contributions
credited  to his or her  account  will be  returned to him or her and his or her
option terminated.

                                      -5-

<PAGE>


                  (d) A participant's  withdrawal from an offering will not have
any effect upon his or her  eligibility to participate in a succeeding  offering
or in any similar plan which may hereafter be adopted by the Company.

         11. Automatic Withdrawal. If the fair market value of the shares on any
Purchase Date of an Offering  Period,  other than the final  Purchase Date of an
Offering Period, is less than the fair market value of the shares on the initial
Offering  Date  for  such  Offering  Period,   then  every   participant   shall
automatically  (i) be withdrawn  from such Offering  Period at the close of such
Purchase Date and after the acquisition of shares for such Purchase Period,  and
(ii) be enrolled in a new twenty-four  (24) month Offering Period  commencing on
the first  business day  subsequent to such  Purchase  Period,  with  subsequent
Offering Periods commencing in twenty-four (24) month periods thereafter.

         12. Interest.  No  interest  shall  accrue  on  the  Contributions of a
             participant in the Plan.

         13. Stock.

                  (a) The maximum number of shares of the Company's Common Stock
which shall be made  available for sale under the Plan shall be 500,000  shares,
subject to adjustment upon changes in  capitalization of the Company as provided
in Section 18. If the total number of shares which would otherwise be subject to
options  granted  pursuant to Section 7(a) on the  Offering  Date of an Offering
Period  exceeds  the  number  of shares  then  available  under the Plan  (after
deduction  of all  shares  for which  options  have been  exercised  or are then
outstanding),  the  Company  shall  make a pro  rata  allocation  of the  shares
remaining  available  for  option  grant  in as  uniform  a  manner  as shall be
practicable  and as it shall  determine  to be  equitable.  In such  event,  the
Company  shall give  written  notice of such  reduction  of the number of shares
subject to the option to each  Employee  affected  thereby  and shall  similarly
reduce the rate of Contributions, if necessary.

                  (b) The  participant  will have no interest or voting right in
shares covered by his or her option until such option has been exercised.

                  (c) Shares to be  delivered  to a  participant  under the Plan
will be  registered in the name  of  the  participant  or  in  the  name  of the
participant and his or her spouse.

         14. Administration. The Board, or a committee named by the Board, shall
supervise and administer the Plan and shall have full power to adopt,  amend and
rescind any rules deemed desirable and appropriate for the administration of the
Plan and not inconsistent with the Plan, to construe and interpret the Plan, and
to make all other  determinations  necessary or advisable for the administration
of the Plan. The  composition of the committee  shall be in accordance  with the
requirements  to obtain or retain any available  exemption from the operation of
Section 16(b) of the Exchange Act pursuant to Rule 16b-3 promulgated thereunder.

         15. Designation of Beneficiary.

                  (a) A  participant  may   file  a  written  designation  of  a
beneficiary   who  is  to  receive  any  shares  and  cash,  if  any,  from  the
participant's  account under the Plan in the event of

                                      -6-

<PAGE>


such participant's death subsequent to the end of a Purchase Period but prior to
delivery to him or her of such shares and cash. In addition,  a participant  may
file a written  designation of a beneficiary who is to receive any cash from the
participant's  account under the Plan in the event of such  participant's  death
prior to the Purchase Date of an Offering  Period.  If a participant  is married
and the  designated  beneficiary  is not the spouse,  spousal  consent  shall be
required for such designation to be effective.

                  (b) Such  designation  of  beneficiary  may be  changed by the
participant  (and his or her spouse,  if any) at any time by written notice.  In
the event of the death of a  participant  and in the  absence  of a  beneficiary
validly   designated  under  the  Plan  who  is  living  at  the  time  of  such
participant's  death,  the Company  shall deliver such shares and/or cash to the
executor  or  administrator  of the  estate  of the  participant,  or if no such
executor or administrator  has been appointed (to the knowledge of the Company),
the  Company,  in its  discretion,  may deliver  such shares  and/or cash to the
spouse or to any one or more dependents or relatives of the  participant,  or if
no spouse,  dependent  or relative is known to the  Company,  then to such other
person as the Company may designate.

         16. Transferability.  Neither Contributions credited to a participant's
account nor any rights  with  regard to the  exercise of an option or to receive
shares  under  the Plan  may be  assigned,  transferred,  pledged  or  otherwise
disposed  of  in  any  way  (other  than  by  will,  the  laws  of  descent  and
distribution, or as provided in Section 15) by the participant. Any such attempt
at assignment,  transfer,  pledge or other  disposition shall be without effect,
except that the  Company may treat such act as an election to withdraw  funds in
accordance with Section 10.

         17. Use  of  Funds.  All  Contributions received or held by the Company
under the Plan may be used by  the  Company  for  any corporate purpose, and the
Company shall not be obligated to segregate such Contributions.

         18.   Reports.   Individual   accounts  will  be  maintained  for  each
participant  in the Plan.  Statements of account will be given to  participating
Employees  promptly following the Purchase Date, which statements will set forth
the amounts of Contributions, the per share purchase price, the number of shares
purchased and the remaining cash balance, if any.

         19. Adjustments Upon Changes in Capitalization; Corporate Transactions.

                  (a)  Adjustment.   Subject  to  any  required  action  by  the
shareholders  of the Company,  the number of shares of Common  Stock  covered by
each option  under the Plan which has not yet been  exercised  and the number of
shares of Common Stock which have been  authorized  for issuance  under the Plan
but have not yet been placed under option  (collectively,  the  "Reserves"),  as
well as the price per share of Common  Stock  covered by each  option  under the
Plan which has not yet been exercised, shall be proportionately adjusted for any
increase or decrease in the number of issued  shares of Common  Stock  resulting
from a  stock  split,  reverse  stock  split,  stock  dividend,  combination  or
reclassification  of the Common Stock,  or any other increase or decrease in the
number of shares of Common Stock effected  without receipt of  consideration  by
the Company; provided, however, that conversion of any convertible securities of
the  Company  shall  not be deemed to have been  "effected  without  receipt  of
consideration".

                                      -7-

<PAGE>


Such adjustment shall be made by the Board, whose  determination in that respect
shall be final, binding and conclusive.  Except as expressly provided herein, no
issue by the Company of shares of stock of any class, or securities  convertible
into shares of stock of any class,  shall  affect,  and no  adjustment by reason
thereof  shall be made with  respect to, the number or price of shares of Common
Stock subject to an option.

                  (b)  Corporate  Transactions.  In the  event  of the  proposed
dissolution or liquidation  of the Company,  the Offering  Period will terminate
immediately prior to the consummation of such proposed action,  unless otherwise
provided by the Board.  In the event of a proposed sale of all or  substantially
all of the  assets of the  Company,  or the merger of the  Company  with or into
another  corporation,  each  option  under  the  Plan  shall  be  assumed  or an
equivalent option shall be substituted by such successor corporation or a parent
or subsidiary of such successor corporation, unless the Board determines, in the
exercise of its sole discretion and in lieu of such assumption or  substitution,
to shorten the Offering  Period then in progress by setting a new Purchase  Date
(the "New Purchase  Date").  If the Board  shortens the Offering  Period then in
progress in lieu of assumption or  substitution in the event of a merger or sale
of assets, the Board shall notify each participant in writing, at least ten (10)
days  prior to the New  Purchase  Date,  that the  Purchase  Date for his or her
option has been changed to the New Purchase Date and that his or her option will
be exercised  automatically on the New Purchase Date,  unless prior to such date
he or she has withdrawn from the Offering  Period as provided in Section 10. For
purposes of this paragraph,  an option granted under the Plan shall be deemed to
be assumed if,  following the sale of assets or merger,  the option  confers the
right to  purchase,  for each  share  of  option  stock  subject  to the  option
immediately prior to the sale of assets or merger,  the  consideration  (whether
stock,  cash or other securities or property)  received in the sale of assets or
merger by  holders of Common  Stock for each  share of Common  Stock held on the
effective date of the transaction  (and if such holders were offered a choice of
consideration,  the type of consideration chosen by the holders of a majority of
the  outstanding  shares  of  Common  Stock);  provided,  however,  that if such
consideration  received  in the sale of assets or merger was not  solely  common
stock of the successor  corporation  or its parent (as defined in Section 424(e)
of the Code),  the Board may, with the consent of the successor  corporation and
the participant,  provide for the  consideration to be received upon exercise of
the option to be solely common stock of the successor  corporation or its parent
equal in fair market value to the per share consideration received by holders of
Common Stock and the sale of assets or merger.

                  The Board may, if it so determines in the exercise of its sole
discretion, also make provision for adjusting the Reserves, as well as the price
per share of Common Stock covered by each outstanding  option, in the event that
the  Company  effects  one or more  reorganizations,  recapitalizations,  rights
offerings or other increases or reductions of shares of its  outstanding  Common
Stock,  and in the event of the Company being  consolidated  with or merged into
any other corporation.

         20.      Amendment or Termination.

                  (a) The  Board of  Directors  of the  Company  may at any time
terminate  or amend  the  Plan.  Except  as  provided  in  Section  19,  no such
termination may affect options previously granted, nor may an amendment make any
change in any option theretofore granted

                                      -8-

<PAGE>


which  adversely  affects the rights of any  participant.  In  addition,  to the
extent  necessary  to comply  with Rule 16b-3 under the  Exchange  Act, or under
Section 423 of the Code (or any  successor  rule or provision or any  applicable
law or  regulation),  the Company  shall obtain  shareholder  approval in such a
manner and to such a degree as so required.

                  (b) Without  shareholder consent and without regard to whether
any participant  rights may be considered to have been adversely  affected,  the
Board (or its  committee)  shall be entitled to change the Offering  Periods and
Purchase  Periods,  limit the  frequency  and/or number of changes in the amount
withheld during an Offering  Period,  establish the exchange ratio applicable to
amounts  withheld  in  a  currency  other  than  U.S.  dollars,  permit  payroll
withholding  in excess of the amount  designated  by a  participant  in order to
adjust for delays or mistakes in the Company's  processing of properly completed
withholding  elections,  establish  reasonable  waiting and  adjustment  periods
and/or accounting and crediting procedures to ensure that amounts applied toward
the  purchase of Common  Stock for each  participant  properly  correspond  with
amounts withheld from the participant's  Compensation,  and establish such other
limitations or procedures as the Board (or its committee) determines in its sole
discretion advisable which are consistent with the Plan.

         21. Notices.  All notices or other  communications  by a participant to
the Company  under or in  connection  with the Plan shall be deemed to have been
duly given when  received in the form  specified by the Company at the location,
or by the person, designated by the Company for the receipt thereof.

         22. Conditions Upon Issuance of Shares. Shares shall not be issued with
respect to an option  unless the  exercise of such option and the  issuance  and
delivery of such  shares  pursuant  thereto  shall  comply  with all  applicable
provisions  of law,  domestic or foreign,  including,  without  limitation,  the
Securities Act of 1933, as amended,  the Exchange Act, the rules and regulations
promulgated  thereunder,  and the  requirements of any stock exchange upon which
the shares may then be listed,  and shall be further  subject to the approval of
counsel for the Company with respect to such compliance.

                  As a condition to the  exercise of an option,  the Company may
require the person  exercising  such option to represent and warrant at the time
of any such exercise that the shares are being purchased only for investment and
without  any  present  intention  to sell or  distribute  such shares if, in the
opinion of counsel for the Company,  such a representation is required by any of
the aforementioned applicable provisions of law.

         23. Term of Plan;  Effective Date. The Plan shall become effective upon
the earlier to occur of its  adoption by the Board of  Directors or its approval
by the  shareholders  of the Company.  It shall continue in effect for a term of
twenty (20) years unless sooner terminated under Section 20.

         24. Additional  Restrictions of Rule 16b-3. The terms and conditions of
options granted  hereunder to, and the purchase of shares by, persons subject to
Section 16 of the Exchange Act shall comply with the  applicable  provisions  of
Rule  16b-3.  This Plan  shall be  deemed to  contain,  and such  options  shall
contain, and the shares issued upon exercise thereof

                                      -9-

<PAGE>


shall be subject to,  such  additional  conditions  and  restrictions  as may be
required by Rule 16b-3 to qualify for the maximum  exemption  from Section 16 of
the Exchange Act with respect to Plan transactions.


                                      -10-

<PAGE>


                         SCICLONE PHARMACEUTICALS, INC.


                        1996 EMPLOYEE STOCK PURCHASE PLAN
                             SUBSCRIPTION AGREEMENT




                                                             New Election ______
                                                       Change of Election ______


         1. I,  ________________________,  hereby  elect to  participate  in the
SCICLONE  PHARMACEUTICALS,  INC. 1996 Employee  Stock Purchase Plan (the "Plan")
for the Offering  Period  ______________,  19__ to  _______________,  19__,  and
subscribe to purchase  shares of the Company's  Common Stock in accordance  with
this Subscription Agreement and the Plan.

         2.  I  elect  to  have  Contributions  in the  amount  of  ____%  of my
Compensation,  as those terms are defined in the Plan, applied to this purchase.
I understand  that this amount must not be less than 1% and not more than 15% of
my  Compensation  during the Offering  Period.  (Please note that no  fractional
percentages are permitted).

         3. I hereby authorize payroll  deductions from each paycheck during the
Offering Period at the rate stated in Item 2 of this Subscription  Agreement.  I
understand  that all  payroll  deductions  made by me shall  be  credited  to my
account under the Plan and that I may not make any additional payments into such
account.  I understand that all payments made by me shall be accumulated for the
purchase of shares of Common Stock at the applicable  purchase price  determined
in accordance with the Plan. I further  understand that, except as otherwise set
forth in the Plan, shares will be purchased for me automatically on the Purchase
Date of each Offering Period unless I otherwise withdraw from the Plan by giving
written notice to the Company for such purpose.

         4.  I  understand  that I may  discontinue  at any  time  prior  to the
Purchase  Date my  participation  in the Plan as  provided  in Section 10 of the
Plan.  I  also  understand  that I can  increase  or  decrease  the  rate  of my
Contributions  on one occasion  only during each six (6) month period  during an
Offering Period by completing and filing a new Subscription  Agreement with such
increase or decrease  taking  effect as of the  beginning of the calendar  month
following  the date of filing  of the new  Subscription  Agreement,  if filed at
least ten (10) business days prior to the  beginning of such month.  Further,  I
may change the rate of deductions  for future  Offering  Periods by filing a new
Subscription  Agreement,  and  any  such  change  will  be  effective  as of the
beginning of the next Offering Period. In addition, I acknowledge that, unless I
discontinue my  participation in the Plan as provided in Section 10 of the Plan,
my election will continue to be effective for each successive Offering Period.


<PAGE>



         5. I have received a copy of the Company's  most recent  description of
the  Plan  and a copy  of the  complete  "SCICLONE  PHARMACEUTICALS,  INC.  1996
Employee Stock Purchase Plan." I understand that my participation in the Plan is
in all respects subject to the terms of the Plan.

         6. Shares  purchased  for me under the Plan  should be  issued  in  the
name(s) of (name of employee or employee and spouse only):

                                            ------------------------------------

                                            ------------------------------------

         7.       In the event of my death,  I hereby  designate  the  following
as my  beneficiary(ies)  to receive all payments and shares due to me  under the
Plan:



NAME:  (Please print)                      -------------------------------------
                                           (First)       (Middle)        (Last)

- --------------------                       -------------------------------------
(Relationship)                             (Address)

                                           -------------------------------------

         8. I understand that if I dispose of any shares received by me pursuant
to the Plan  within 2 years  after  the  Offering  Date  (the  first  day of the
Offering Period during which I purchased such shares) or within 1 year after the
Purchase  Date,  I will be treated  for  federal  income tax  purposes as having
received  ordinary  compensation  income at the time of such  disposition  in an
amount  equal to the  excess  of the fair  market  value  of the  shares  on the
Purchase Date over the price which I paid for the shares,  regardless of whether
I disposed  of the shares at a price  less than their fair  market  value at the
Purchase  Date.  The remainder of the gain or loss,  if any,  recognized on such
disposition will be treated as capital gain or loss.

                  I hereby agree to notify the Company in writing within 30 days
after the date of any such disposition,  and I will make adequate  provision for
federal,  state or other tax withholding  obligations,  if any, which arise upon
the disposition of the Common Stock.  The Company may, but will not be obligated
to,  withhold from my compensation  the amount  necessary to meet any applicable
withholding  obligation including any withholding necessary to make available to
the Company any tax  deductions  or benefits  attributable  to the sale or early
disposition of Common Stock by me.

         9. If I dispose  of such  shares at any time  after  expiration  of the
2-year and 1-year  holding  periods,  I  understand  that I will be treated  for
federal income tax purposes as having received  compensation  income only to the
extent of an amount  equal to the  lesser of (1) the  excess of the fair  market
value of the shares at the time of such disposition over the purchase

                                      -2-

<PAGE>


price  which I paid for the  shares  under  the  option,  or (2) 15% of the fair
market value of the shares on the Offering  Date.  The  remainder of the gain or
loss, if any,  recognized on such disposition will be treated as capital gain or
loss.

         I understand  that this tax summary is only a summary and is subject to
change. I further  understand that I should consult a tax advisor concerning the
tax implications of the purchase and sale of stock under the Plan.

         10. I  hereby  agree  to  be  bound  by  the  terms  of  the Plan.  The
effectiveness  of this  Subscription Agreement is dependent  upon my eligibility
to participate in the Plan.



SIGNATURE: ________________________________________

SOCIAL SECURITY #: ________________________________

DATE: _____________________________________________



SPOUSE'S SIGNATURE (necessary
if beneficiary is not spouse):


- ---------------------------------------------------
(Signature)


- ---------------------------------------------------
(Print name)

                                      -3-


<PAGE>


                         SCICLONE PHARMACEUTICALS, INC.


                        1996 EMPLOYEE STOCK PURCHASE PLAN

                              NOTICE OF WITHDRAWAL



         I,   __________________________,    hereby   elect   to   withdraw   my
participation in the SCICLONE PHARMACEUTICALS, INC. 1996 Employee Stock Purchase
Plan (the "Plan") for the Offering Period _________.  This withdrawal covers all
Contributions  credited to my account and is  effective  on the date  designated
below.

         I understand that all Contributions credited to my account will be paid
to me within ten (10)  business days of receipt by the Company of this Notice of
Withdrawal  and  that  my  option  for the  current  period  will  automatically
terminate,  and that no further  Contributions for the purchase of shares can be
made by me during the Offering Period.

         The undersigned  further understands and agrees that he or she shall be
eligible to participate in succeeding offering periods only by delivering to the
Company a new Subscription Agreement.


Dated:___________________                    ___________________________________
                                             Signature of Employee


                                             ___________________________________
                                             Social Security Number






                               September 17, 1996


SciClone Pharmaceuticals, Inc.
901 Mariner's Island Boulevard
San Mateo, California  94404

         Registration Statement on Form S-8
         ----------------------------------

Ladies and Gentlemen:

         We  have  examined  the   Registration   Statement  on  Form  S-8  (the
"Registration  Statement")  filed  by  you  with  the  Securities  and  Exchange
Commission (the  "Commission") on or about September 17, 1996 in connection with
the  registration  under the Securities  Act of 1933, as amended,  of a total of
500,000 shares of your Common Stock (the  "Shares")  reserved for issuance under
the 1996 Employee Stock  Purchase Plan. As your counsel in connection  with this
transaction,  we have examined the  proceedings  taken and are familiar with the
proceedings proposed to be taken by you in connection with the sale and issuance
of the Shares.

         It is our opinion that upon conclusion of the  proceedings  being taken
or contemplated by us, as your counsel, to be taken prior to the issuance of the
Shares,  and upon completion of the  proceedings  being taken in order to permit
such  transactions  to be carried out in accordance  with the securities laws of
the various states where required, the Shares when issued and sold in the manner
described  in the  Registration  Statement  will be legally and validly  issued,
fully paid and non-assessable.

         We consent to the use of this opinion as an exhibit to the Registration
Statement and further  consent to the use of our name wherever  appearing in the
Registration  Statement,  including the Prospectus  constituting a part thereof,
and in any amendment thereto.

                                             Very truly yours,

                                             VENTURE LAW GROUP
                                             A Professional Corporation



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