SCICLONE PHARMACEUTICALS INC
10-Q, 1996-11-13
PHARMACEUTICAL PREPARATIONS
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                                    FORM 10-Q


                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

(Mark One)

[X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
               SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 1996

                                       OR

[ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE 
               SECURITIES EXCHANGE ACT OF 1934

For the transition period from ________________________to ______________________

Commission file number:  0-19825


                         SCICLONE PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)

           California                                   94-3116852
(State or other jurisdiction of                      (I.R.S. employer
incorporation or organization)                      identification no.)


901 Mariners Island Blvd., Suite 315, San Mateo, California              94404
           (Address of principal executive offices)                   (Zip code)

                                 (415) 358-3456
              (Registrant's telephone number, including area code)

                                 Not Applicable
              (Former name, former address and former fiscal year,
                          if changed since last report)

           Indicate  by check  mark  whether  the  registrant  (1) has filed all
reports  required to be filed by Section 13 or 15(d) of the Securities  Exchange
Act of 1934 during the preceding 12 months (or for such shorter  period that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days

             Yes       X                        No
                -----------------                 ----------------
           As of October 31, 1996,  17,610,195 shares of the registrant's Common
Stock, no par value, were issued and outstanding.


<PAGE>


                         SCICLONE PHARMACEUTICALS, INC.



                                      INDEX
                                                                            PAGE
PART I.  FINANCIAL INFORMATION                                               NO.

Item 1.  Consolidated Financial Statements

         Consolidated Balance Sheets
              September 30, 1996 and December 31, 1995                         3

         Consolidated Statements of Operations
              Three and nine months ended September 30, 1996 and 1995          4

         Consolidated Statements of Cash Flows
              Nine months ended September 30, 1996 and 1995                    5

         Notes to Consolidated Financial Statements                            6

Item 2.  Management's Discussion and Analysis of Financial
              Condition and Results of Operations                              7

PART II. OTHER INFORMATION

Item 4.  Submission of Matters to a Vote of Security Holders                  11

Item 6.  Exhibits and Reports on Form 8-K                                     11


Signatures                                                                    12

                                       2

<PAGE>



PART I.  FINANCIAL INFORMATION

Item  1. Consolidated Financial Statements

                         SCICLONE PHARMACEUTICALS, INC.

                           CONSOLIDATED BALANCE SHEETS

                                     ASSETS

                                                  September 30,    December 31,
                                                       1996            1995
                                                  -------------    -------------
                                                    (unaudited)
Current assets:
    Cash and cash equivalents                     $   4,243,540    $   3,986,307
    Short-term investments                            8,723,312       15,467,685
    Accounts receivable, net                            133,106          108,410
    Inventory                                         2,465,363        2,360,479
    Prepaid expenses and other current assets         2,076,860        1,955,930
                                                  -------------    -------------
Total current assets                                 17,642,181       23,878,811

Property and equipment, net                             298,630          313,703
Other assets                                             36,032           58,381
Long-term investments                                25,068,593       27,935,835
Notes receivable from officers                        2,653,014        1,964,065
                                                  -------------    -------------
Total assets                                      $  45,698,450    $  54,150,795
                                                  =============    =============

                      LIABILITIES AND SHAREHOLDERS' EQUITY

Current liabilities:
    Accounts payable                              $     345,451    $     472,477
    Accrued compensation and benefits                   798,874        1,086,904
    Accrued clinical trial expense                    1,190,048        2,054,741
    Accrued professional fees                         1,501,501          765,000
    Other accrued expenses                              374,473          216,411
                                                  -------------    -------------
Total current liabilities                             4,210,347        4,595,533
                                                  -------------    -------------

Shareholders' equity:
    Preferred stock, no par value; 10,000,000
         shares authorized; no shares issued
         and outstanding                                   --               --
     Common stock, no par value; 75,000,000
        shares authorized; 17,600,492 and
        16,807,257 shares issued and outstanding    109,580,480      105,915,548
     Net unrealized (loss) gain on
        available-for-sale securities                  (246,532)         450,086
     Accumulated deficit                            (67,845,845)    (56,605,519)
     Deferred compensation                                 --          (204,853)
                                                  -------------    -------------
Total shareholders' equity                           41,488,103       49,555,262
                                                  -------------    -------------
Total liabilities and shareholders' equity        $  45,698,450    $  54,150,795
                                                  =============    =============

                 See notes to consolidated financial statements

                                       3

<PAGE>


        
                                              SCICLONE PHARMACEUTICALS, INC.
<TABLE>
                        
                                           CONSOLIDATED STATEMENTS OF OPERATIONS
                                                        (unaudited)
                        
                
 
<CAPTION>

                                               Three months ended                Nine months ended
                                                   September 30,                   September 30,
                                                1996            1995            1996            1995
                                           ------------    ------------    ------------    ------------

<S>                                        <C>             <C>             <C>             <C>         
Product sales                              $    152,258    $    116,575    $    400,603    $    161,773

Cost of product sales                           151,696         274,234         555,156         477,527
                                           ------------    ------------    ------------    ------------
Gross profit                                        562        (157,659)       (154,553)       (315,754)
                                                                                                    

Operating expenses:
     Research and development                 2,535,828       2,876,734       7,612,902       7,837,265
     Marketing                                1,046,904         939,724       3,148,017       2,979,625
     General and administrative                 777,604         692,966       2,340,938       2,190,869
                                           ------------    ------------    ------------    ------------
Total operating expenses                      4,360,336       4,509,424      13,101,857      13,007,759
                                           ------------    ------------    ------------    ------------

Loss from operations                         (4,359,774)     (4,667,083)    (13,256,410)    (13,323,513)

Interest and investment income, net             588,407         954,595       2,016,084       2,359,019
                                           ------------    ------------    ------------    ------------

Net loss                                   $ (3,771,367)   $ (3,712,488)   $(11,240,326)   $(10,964,494)
                                           ============    ============    ============    ============
Net loss per share                         $      (0.21)   $      (0.22)   $      (0.65)   $      (0.65
                                           ============    ============    ============    ============
Weighted average shares used in
     computing per share amounts             17,579,717      16,781,285      17,359,726      16,913,767
                                           ============    ============    ============    ============

<FN>

                                            See notes to consolidated financial statements
</FN>
</TABLE>
                                                                    4

<PAGE>


                                      SCICLONE PHARMACEUTICALS, INC.
<TABLE>

                                  CONSOLIDATED STATEMENTS OF CASH FLOWS
                                             (unaudited)
<CAPTION>

                                                                       Nine months ended
                                                                         September 30,
                                                                     1996            1995
                                                                 ------------    ------------
Operating activities:
<S>                                                              <C>             <C>          
   Net loss                                                      $(11,240,326)   $(10,964,494)
   Adjustments to reconcile net loss to net
   cash used in operating activities:
      Depreciation and amortization                                   276,854         381,839
      Changes in operating assets and liabilities:
         Accounts receivable                                          (24,696)       (100,201)
         Inventory                                                   (104,884)     (1,495,513)
         Prepaid expenses and other assets                           (787,530)     (1,932,055)
         Accounts payable and other accrued expenses                   31,036         182,183
         Accrued clinical trial expense                              (864,693)         93,456
         Accrued professional fees                                    736,501         203,750
         Accrued compensation and benefits                           (288,030)       (505,419)
                                                                 ------------    ------------
Net cash used in operating activities                             (12,265,768)    (14,136,454)
                                                                 ------------    ------------

Investing activities:
   Purchase of property and equipment                                 (56,928)       (146,434)
   Sale of short and long term investments, net                     8,914,997      16,154,075
                                                                 ------------    ------------
Net cash provided by investing activities                           8,858,069      16,007,641
                                                                 ------------    ------------

Financing activities:
   Proceeds from issuance of common stock, net                      3,664,932         161,687
   Repurchase of common stock                                            --        (1,924,897)
                                                                 ------------    ------------
Net cash provided by (used in) financing activities                 3,664,932      (1,763,210)
                                                                 ------------    ------------
Net increase in cash and cash equivalents                             257,233         107,977
Cash and cash equivalents, beginning of period                      3,986,307       8,292,888
                                                                 ------------    ------------
Cash and cash equivalents, end of period                         $  4,243,540    $  8,400,865
                                                                 ============    ============

Supplemental disclosures of noncash financing activities:
   Net unrealized (loss) gain on available-for-sale securities       (696,618)      3,196,269
<FN>

                 See notes to consolidated financial statements
</FN>
</TABLE>
                                       5

<PAGE>


                         SCICLONE PHARMACEUTICALS, INC.

                   Notes to Consolidated Financial Statements


1.   The  accompanying  unaudited  consolidated  financial  statements have been
     prepared  in  conformity  with  generally  accepted  accounting  principles
     consistent  with those applied in, and should be read in conjunction  with,
     the audited financial  statements for the year ended December 31, 1995. The
     interim  financial  information  reflects all normal recurring  adjustments
     which are, in the opinion of management,  necessary for a fair presentation
     of the results for the interim and commencement to date periods  presented.
     The interim results are not necessarily  indicative of results for the full
     year.

2.   Net loss per share has been computed  using the weighted  average number of
     common shares outstanding  during each period presented.  Common equivalent
     shares for  outstanding  options  and  warrants  were not  included  in the
     weighted average shares outstanding because the effect of including them is
     antidilutive.
 
3.   The following is a summary of  available-for  sale  securities at September
     30, 1996:
<TABLE>

                                            Available-for-Sale Securities
                                       -----------------------------------------
<CAPTION>
                                           Gross          Gross        Estimated
                                        Unrealized     Unrealized         Fair
                             Cost          Gains         Losses           Value
                        ------------   ------------   ------------    ------------
<S>                     <C>            <C>            <C>             <C>
U.S. Government &
  Agency obligations    $ 22,428,753   $     15,125   $   (272,634)   $ 22,171,244
Corporate obligations     11,409,684         16,383        (37,456)     11,388,611
Corporate securities         200,000         32,050             --         232,050
                        ------------   ------------   ------------    ------------
                        $ 34,038,437   $     63,558   $   (310,090)   $ 33,791,905
                        ============   ============   ============    ============
</TABLE>

The  amortized cost and estimated  fair value of debt and marketable  securities
at September 30, 1996 by contractual maturity are shown below.

                                                                      Estimated
                                                                        Fair
                                                         Cost           Value
                                                     -----------     -----------
Due in one year or less                              $ 8,492,846     $ 8,491,262
Due after one year through three years                17,560,517      17,382,475
Due after three years                                  7,785,074       7,686,118
                                                     -----------     -----------
                                                      33,838,437      33,559,855
Corporate securities                                     200,000         232,050
                                                     -----------     -----------
                                                     $34,038,437     $33,791,905
                                                     ===========     ===========

4.   The following is a summary of inventories at September 30, 1996:

     Raw materials             $2,447,028
     Finished goods                18,335
                               ----------
                               $2,465,363
                               ==========


                                       6

<PAGE>


Item 2. Management's  Discussion and Analysis of Financial Condition and Results
        of Operations


      Except for historical information contained herein, the following material
includes  forward-looking  statements,  including  statements regarding expected
revenues and  anticipated  expense levels.  Such forward looking  statements are
subject  to  certain  risks and  uncertainties  and  actual  results  could vary
materially. These risks and uncertainties include the Company's current reliance
on a single product,  ZADAXIN(R) thymosin alpha 1, for its revenues, the absence
of  regulatory  approval  for  ZADAXIN  in  significant  markets,  uncertainties
regarding  prospects for regulatory  approvals based on existing  clinical data,
risks  associated with the  manufacture and supply of ZADAXIN and  relationships
with collaborative  partners, and competition from competing therapies,  as well
as other risks and  uncertainties  described  herein and in the Company's Annual
Report on Form 10-K and its other  reports  filed with the  Securities  Exchange
Commission.

      The Company is an international  biopharmaceutical company involved in the
acquisition, development and commercialization of pharmaceuticals worldwide. The
Company's  focus  is  on   therapeutics   for  diseases  that  are  chronic  and
life-threatening,  including  hepatitis  B  and  C,  cancer  and  immune  system
disorders.  To date, the Company's  principal focus has been the development and
commercialization of ZADAXIN.

      From  commencement of operations  through  September 30, 1996, the Company
incurred a  cumulative  net loss of  approximately  $67.8  million.  The Company
expects its  operating  expenses to increase  over the next several  years as it
expands  its  research  and   development,   clinical   testing  and   marketing
capabilities.  The Company's ability to achieve a profitable level of operations
currently  is  dependent  in large part on  securing  regulatory  approvals  for
ZADAXIN in additional countries,  successfully  launching ZADAXIN once approved,
meeting  increased  demand  for  ZADAXIN,  if it  arises,  acquiring  rights  to
additional  drugs,  and  entering  into and  extending  agreements  for  product
development and commercialization,  where appropriate. There can be no assurance
that the Company  will be able to attain  these  objectives  or that the Company
will ever achieve a profitable level of operations.

      The Company's  operating  results may fluctuate from period to period as a
result of, among other  things,  the timing and costs  associated  with clinical
trials and the regulatory  approval  process,  and the acquisition of additional
product rights.  The Company  participates in a highly dynamic  industry,  which
often results in significant volatility of the Company's common stock price. Any
setbacks  in  clinical  trials,  in  the  regulatory   approval  process  or  in
relationships  with  collaborative  partners,  and any  shortfalls in revenue or
earnings from levels expected by securities analysts,  among other developments,
have in the past had and could in the future have an immediate  and  significant
adverse  effect on the trading price of the Company's  common stock in any given
period.

                                       7


<PAGE>


Results of Operations

      Product  sales reached  approximately  $152,000 and $401,000 for the three
and nine month periods ended  September 30, 1996,  respectively,  as compared to
approximately  $117,000 and $162,000 for the corresponding  periods in 1995. The
Company commenced shipment of ZADAXIN in the second quarter of 1995 and has been
recording product sales under a named patient registration  program.  Currently,
the Company has received  approval to market ZADAXIN in the Peoples  Republic of
China, the Republic of the Phillipines and Singapore.  In addition,  the Company
has filed for approval to market  ZADAXIN in several  countries and  anticipates
additional filings in other countries.  As a result, the Company expects product
sales to increase  starting in the fourth quarter of 1996 upon the  commencement
of the commercial launch of ZADAXIN in its approved  markets.  The level of such
product sales  increase is dependent  upon  successfully  launching  ZADAXIN and
receipt of additional ZADAXIN marketing approvals.  Although the Company remains
optimistic  regarding the prospects of ZADAXIN,  there can be no assurance  that
the Company will achieve significant levels of product sales.

      Cost of product  sales was  approximately  $152,000  and  $555,000 for the
three and nine month periods ended September 30, 1996, respectively, as compared
to approximately  $274,000 and $478,000 for the  corresponding  periods in 1995.
The decrease in the three month period is  primarily  attributable  to decreased
fixed  inventoriable  costs offset by increased product sales. The change in the
nine month period is primarily  due to increased  product  sales and fixed costs
associated with acquiring and warehousing  inventory offset by decreased payroll
costs.  The  Company  expects  cost of  product  sales to vary from  quarter  to
quarter,  dependent  upon the level of product sales and the absorption of fixed
product-related costs.

      Research  and  development  expenses  were  approximately  $2,536,000  and
$7,613,000  for the three and nine  month  periods  ended  September  30,  1996,
respectively,  as compared to  approximately  $2,877,000  and $7,837,000 for the
corresponding  periods in 1995.  These  decreases are primarily  attributable to
decreased   clinical   trials  and  regulatory   expenses  offset  by  increased
pre-clinical  development  expenses.  In April  1996,  the  Company  acquired an
exclusive  license  for CPX, a  synthetic  compound  developed  by the  National
Institutes of Health as a potential  treatment for cystic fibrosis.  The Company
has  incurred  additional  pre-clinical  development  expenses to  initiate  the
development  of this  compound.  The  decrease in clinical  trial  expenses  was
primarily a result of  completion  of the ZADAXIN  Taiwan Phase III  Hepatitis B
trial during the first half of 1996. The Company is currently reviewing its U.S.
and European ZADAXIN clinical trial strategy and the results of this review will
have a significant effect on the Company's research and development expenses. In
general,the  Company expects research and development  expenses to increase over
the next several  years and to vary quarter to quarter as the Company  initiates
additional  clinical  trials and testing,  acquires  product  rights,  initiates
additional trials, and expands regulatory activities.

      Marketing  expenses were  approximately  $1,047,000 and $3,148,000 for the
three and nine month periods ended September 30, 1996, respectively, as compared
to $940,000  and  $2,980,000  for the  corresponding  periods in the prior year.
These increases are primarily  attributable to increased  professional services,
primarily  consulting  services expenses  regarding the launch of ZADAXIN in its
approved markets later this year,  offset by decreased  payroll costs related to
an executive officer who left the Company in 1995. The Company expects marketing
expenses to increase  significantly in the next several quarters and years as it
anticipates  expanding its  commercialization and marketing efforts and pursuing
other strategic relationships.

                                    8


<PAGE>

      General  and  administrative  expenses  were  approximately  $778,000  and
$2,341,000  for the three and nine  month  periods  ended  September  30,  1996,
respectively,  as compared to  approximately  $693,000  and  $2,191,000  for the
corresponding   periods  in  the  prior  year.  These  increases  are  primarily
attributable  to  increased  payroll  costs  offset by  decreased  expenses  for
professional services, primarily legal services and consulting fees. In the near
term, the Company expects general and administrative expenses to vary quarter to
quarter as the Company  augments its general and  administrative  activities  to
support increased  expenditures on clinical trials and testing,  and regulatory,
pre-commercialization and marketing activities.

      Net  interest  and  investment  income  was  approximately   $588,000  and
$2,016,000  for the three and nine  month  periods  ended  September  30,  1996,
respectively,  as compared to approximately  $955,000 and $2,359,000 in the same
periods in 1995.  The changes  primarily  resulted from  decreased  interest and
investment income due to lower average invested cash balances.


Liquidity and Capital Resources

      At September 30, 1996, the Company had approximately  $38,035,000 in cash,
cash equivalents and highly liquid short and long term investments.

     Net  cash  used  by  the  Company  in  operating   activities  amounted  to
approximately  $12,266,000  for the nine month period ended  September 30, 1996.
Net cash used in  operating  activities  in the 1996 period is greater  than the
Company's  net loss for such  period  primarily  due to cash used for  inventory
purchases,  increases in and  prepayments of certain future period  expenses and
decreases  in amounts owed to third  parties for goods and  services  related to
clinical trial expenses and compensation and benefits. These uses were offset by
noncash charges  associated with  depreciation and amortization and increases in
amounts owed for accounts payable and accrued  professional  fees. Net cash used
in operating activities amounted to approximately $14,136,000 for the nine month
period ended  September 30, 1995.  Net cash used in operating  activities in the
1995 period is greater than the Company's net loss for such period primarily due
to cash used for inventory  purchases,  the  prepayment of certain future period
expenses and payments  reducing accrued  compensation  and benefits.  These uses
were  partially  offset by increases in amounts owed to third  parties for goods
and services  related to clinical  trial  expenses  and  professional  fees,  in
addition to noncash charges associated with depreciation and amortization.

      Net cash provided by investing  activities for the nine month period ended
September  30,  1996  related  to the net sale of  approximately  $8,915,000  of
marketable  securities  offset by the  purchase  of  $57,000  in  equipment  and
furniture.  Net cash provided in investing  activities for the  comparable  1995
period  primarily  resulted  from  the net  sale of  $16,154,000  of  marketable
securities offset by the purchase of $146,000 of equipment and furniture.

      Net cash provided by financing activities for the nine month period ending
September 30, 1996 primarily  consisted of approximately  $3,665,000 in proceeds
received for the issuance of common stock under the Company's stock option plan.
Net cash used in financing activities for the nine month period ending September
30, 1995 related to repurchases of the Company's  common stock of  approximately
$1,925,000  offset by approximately  $162,000 in proceeds received from issuance
of common stock under the Company's stock option plan.

                                       9



<PAGE>

      Management  believes its existing capital  resources and interest on funds
available  are adequate to maintain its current and planned  operations at least
through 1997. However,  the Company's capital  requirements may change depending
upon numerous  factors,  including the availability of  complementary  products,
technologies  and businesses,  the results of clinical  trials and testing,  the
timing of regulatory approvals, developments in relationships with collaborative
partners  and  the  status  of  competitive  products.  If  the  Company  cannot
eventually  generate  sufficient  funds from  operations,  it will need to raise
additional  financing.  There can be no assurance  that such  financing  will be
available on acceptable terms, or at all.

                                       10


<PAGE>


PART II. OTHER INFORMATION

Item 4. Submission of Matters to a Vote of Security Holders

      The Company held its Annual  Meeting of  Shareholders  on July 25, 1996 to
elect five (5) directors, to approve the adoption of the Company's 1996 Employee
Stock Purchase Plan, and to ratify the appointment of the  independent  auditors
of the Company.

      At the Annual Meeting, all of the nominees were elected as follows:
 
                                                               Votes
                                                               -----
                                                      For               Withheld
                                                      ---               --------
Thomas E. Moore                                   15,775,283              42,775
Donald R. Sellers                                 15,772,983              45,075
John D. Baxter, M.D                               12,812,006           3,006,052
Edwin C. Cadman,  M.D                             12,821,956           2,996,102
Jere E. Goyan, Ph.D                               12,823,956           2,994,102

      The shareholders also approved the adoption of the Company's 1996 Employee
Stock Purchase Plan with voting as follows:  14,958,697  for;  194,402  against;
310,591 abstaining; and 354,368 non-votes.

      The  shareholders  also  ratified  the  selection  of Ernst & Young LLP as
independent  auditors  for the Company for the fiscal year ending  December  31,
1996 with  voting  as  follows:  15,758,477  for;  17,851  against;  and  41,730
abstaining.



Item 6. Exhibits and Reports on Form 8-K.

(a)     Exhibits

        Exhibit
        Number                    Description
        -------                   -----------
        10.1    Form  of  Promissory  Note  secured  by Deed  of  Trust  between
                Registrant and Donald R. Sellers

        10.2    Amendment No. 8 to Spieker Lease, dated August 26, 1996

        27      Financial Data Schedule

(b)     Reports on Form 8-K

        None    

                                       11


<PAGE>

                                   SIGNATURES

     Pursuant to the  requirements  of the  Securities and Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                     SCICLONE PHARMACEUTICALS, INC.
                                              (Registrant)




Date:   November 13, 1996                  Donald R. Sellers
                                     -----------------------------
                                           Donald R. Sellers
                                        Chief Executive Officer
                                     (Principal Executive Officer)



Date:   November 13, 1996                   Mark A. Culhane
                                     -----------------------------
                                            Mark A. Culhane
                               Vice President, Finance and Administration
                                      and Chief Financial Officer
                               (Principal Financial & Accounting Officer)


                                       12



                    PROMISSORY NOTE SECURED BY DEED OF TRUST


$1,000,000                                        San Mateo, California
                                                  August 1, 1996


     In  installments  as stated in this  Note,  for value  received,  Donald R.
Sellers and Jolice K. Sellers, husband and wife (together,  "Borrowers"), hereby
promise to pay to  SciClone  Pharmaceuticals,  Inc.,  a  California  corporation
("Lender") or order, at its offices at 901 Mariners Island Boulevard, San Mateo,
California,  or at such other place as Lender may from time to time designate in
writing, the principal sum of one Million Dollars ($1,000,000), with interest on
the  unpaid  balance of  principal  from the date of this Note until paid at the
rate of eight  percent  (8.00%) per annum (the "Note  Rate"),  on the  following
terms:

     I.  Payment:  The principal and interest due pursuant to this Note shall be
paid as follows:

                A. On  September  1, 1996 and on the first day of each  calendar
month  thereafter,  Borrowers shall pay to Lender equal monthly  payments in the
amount  of  Seven  Thousand  Three  Hundred  Thirty  Seven  and  65/100  Dollars
($7,337.65).

                B. The entire  principal  balance  with all then unpaid  accrued
interest  shall be due and payable on or before July 31,  2001,  unless the term
hereof is renewed as set forth herein. At the election of the Lender, the Lender
may extend the term of this Note, which extension shall be deemed effective upon
written notice from Lender to Borrowers delivered at any time before the initial
maturity  date  hereof,  which notice  shall state the  extended  maturity  date
selected by Lender. As of the effective date of such notice,  this Note shall be
extended on all the same terms and  conditions as are set forth  herein,  except
for the extended maturity date.

                C.  Principal  and interest  shall be payable in lawful money of
the United  States.  Interest shall be calculated on the basis of a 360-day year
consisting  of 12 thirty day  months.  Each  payment  shall be applied  first to
interest  then due and the balance of said  installment  shall be applied to the
principal sum.

                D.  This Note may be prepaid at any time, without penalty.

     II. Security: This Note is secured by a deed of trust of even date herewith
made by Borrowers,  as trustor, to North American Title Company, as trustee, for
Lender, as beneficiary (the "Deed of Trust"),  encumbering certain real property
commonly  known as 8 Acorn, Portola Valley,  California (the "Property"),  which
Borrowers occupy as their principal place of residence.



<PAGE>

     III. Default and Acceleration:

     A. Unless  otherwise  prohibited by law, upon the  occurrence of any of the
following events, the Holder of this Note shall have the option,  without demand
or notice, to declare the entire balance of principal of this Note together with
all accrued interest to be immediately due and payable:

                1.  Borrowers  default in the payment of  principal  or interest
when due  pursuant  to the terms  hereof or  default in the  performance  of any
obligation  of  Borrowers  contained  in the Deed of Trust or any other  deed of
trust,   security  agreement  or  other  agreement   (including  any  amendment,
modification or extension  thereof) which may hereafter be executed by Borrowers
for the purpose of securing this Note;

                2. Borrowers  voluntarily  or by operation of law sell,  convey,
assign,  further  encumber or  otherwise  transfer  or agree to sell,  convey or
otherwise  transfer,  all or substantially all, or any portion of, or Borrowers'
interest in the Property;

                3. Ninety (90) days after the voluntary termination by Donald R.
Sellers of his employment with SciClone Pharmaceuticals, Inc.;

                4. One hundred eighty (180) days after the termination of Donald
R. Sellers' employment by SciClone  Pharmaceuticals,  Inc. for Cause, as defined
below;

                5. Three  hundred  sixty  (360) days  after the  termination  of
Donald R. Sellers' employment by SciClone Pharmaceuticals, Inc. without Cause.

As used herein,  the employment of Donald R. Sellers shall be deemed  terminated
for  Cause if a primary  factor  in the  termination  of his  employment  is the
failure by Mr. Sellers to comply with the instructions of the Board of Directors
of SciClone Pharmaceuticals,  Inc., gross negligence,  willful misconduct, fraud
or conviction of any crime.

         IV. Default Interest Rate: If Borrowers fail to make any payment within
fifteen  (15) days after any such  payment  becomes due and  payable,  Borrowers
agree to pay interest on the late  payment,  including  that portion of the late
payment  which  consists of past-due  interest,  at an annual rate (the "Default
Rate")  of three (3)  percent  in  excess  of the Note  Rate,  from the date the
payment was due until Borrowers pays in full all sums due under this Note.


<PAGE>



         V. Attorneys'  Fees: In the event of any default  hereunder,  Borrowers
hereby promise to pay all costs of collection,  including reasonable  attorney's
fees  incurred by Lender  hereof on account of such  collection,  whether or not
suit is filed hereon.

         VI.  Waiver:  The  waiver by Lender  hereof of any breach of or default
under  any  term,  covenant  or  condition  contained  herein  or in  any of the
agreements  referred  to above  shall not be deemed to be a waiver or such term,
covenant or condition or any  subsequent  breach of or default under the same or
any other such term, covenant or condition.

         VII. No Usury:  It is the intent of Borrowers  and Holder that the rate
of interest on the  indebtedness  evidenced  hereby shall not exceed the maximum
rate  permitted  by  applicable  law and  accordingly,  if the rate of  interest
specified herein, or any other payments  specified herein or otherwise  required
to  be  made  by  Borrowers  or  received  by  Holder  in  connection  with  the
indebtedness  evidenced  hereby  and  deemed to be  interest,  shall  exceed the
maximum rate of interest permitted by applicable law then such payments,  to the
extent  they  exceed such  maximum  rate,  shall be deemed to have been made and
received inadvertently,  and shall for all purposes be deemed to be a payment of
and on account of the principal balance of the indebtedness evidenced hereby and
shall be applied accordingly or, at Holder's option, returned to Borrowers.

         VIII. General Provisions:  This Note shall be governed by and construed
in accordance with the laws of the State of California.  The makers,  guarantors
and  endorsers  of this Note hereby  severally  waive  presentment  for payment,
protest and demand,  notice of protest,  demand and dishonor and  nonpayment  of
this Note,  and consent that Lender may extend the time for payment or otherwise
modify the terms of payment  of any part or the whole of the debt  evidenced  by
this Note,  at the request of any person liable  hereon,  and such consent shall
not alter nor diminish the liability of any person.  Borrowers  hereby waive the
defense of the statute of  limitations  in any action on this Note to the extent
permitted by law.

         Borrowers:



                  Donald R. Sellers
          ------------------------------------
                  Donald R. Sellers



                  Jolice K. Sellers
          ------------------------------------
                  Jolice K. Sellers








                           REVISED LEASE AMENDMENT #8


ORIGINAL LEASE DATE:        September 10, 1991

LEASE AMENDMENT DATE:       August 26, 1996

LANDLORD:                   SPIEKER-SINGLETON #68 LIMITED PARTNERSHIP
                            A California Limited Partnership

TENANT:                     SCICLONE PHARMACEUTICALS, INC
                            A California Corporation

Landlord  and Tenant,  by executing  this Lease  Amendment as provided do hereby
amend the Original Lease referred to above as follows:

1.       TERM

         11/01/96 - 04/30/2000

2.       PREMISES

         Effective November 1, 1996 approximately  1,155 square feet of rentable
         space on the second floor (Suite  #265) of San Mateo  BayCenter,  Phase
         II, shall be  incorporated  into the Original  Lease  Agreement.  Total
         square  footage shall  increase from 15,227 to 16,382  rentable  square
         feet.

<TABLE>
3.       RENTAL

<CAPTION>
                                                                                AMOUNT
                                                                                DUE:
                                          Additional         Existing
         11/01/96 - 11/30/96              1,155 rsf.        15,227 rsf.       16,382 rsf.
         --------------------------------------------------------------------------------
         <S>                              <C>              <C>               <C>

         Base Rent                         $1,686.00        $17,236.00        $18,922.00
         Op. Exp. (est. '96)                 $693.00         $9,137.00         $9,830.00
                                             -------         ---------         ---------
         Total Rent                        $2,379.00        $26,373.00        $28,752.00

                                          Additional          Existing
         12/01/96 - 12/31/96              1,155 rsf.       15,227 rsf.       16,382 rsf.
         -------------------------------------------------------------------------------

         Base Rent                         $1,496.26        $17,236.00        $18,732.26
         Op. Exp. (est. '96)                 $693.00        $ 9,137.00        $ 9,830.00
                                             -------        ----------        ----------
         Total Rent                        $2,189.26        $26,373.00        $28,562.26

                                          Additional          Existing
         01/01/97 - 04/30/97              1,155 rsf.       15,227 rsf.       16.382 rsf.
         -------------------------------------------------------------------------------

         Base Rent                         $1,340.00        $17,354.00        $18,694.00
         Op. Exp. (est. '96)                 $693.00         $9,137.00         $9,830.00
                                             -------         ---------         ---------
         Total Rent                        $2,033.00        $26,491.00        $28,524.00

                                          Additional          Existing
         05/01/97 -   12/31/97            1,155 rsf.       15,227 rsf.       16,382 rsf.
         ------------------------------------------------------------------------------ 

         Base Rent                         $1,397.00        $18,018.00        $19,415.00
         Op. Exp. (est. '96)                 $693.00         $9,137.00         $9,830.00
                                             -------         ---------         ---------
         Total Rent                        $2,090.00        $27,155.00        $29,245.00



<PAGE>


SciCione Phanylaccuticals, Inc.
Lease Amendment #8
8/26/96
Page 2

                                            Additional        Existing
         01/01/98 - 04/30/98                1,155 rsf.        15,227 rsf.       16,382 rsf.
         ----------------------------------------------------------------------------------

         Base Rent                           $1,397.00        $18,136.00        $19,533.00
         Op. Exp. (est. '96)                   $693.00         $9,137.00         $9,830.00
                                               -------         ---------         ---------
         Total Rent                          $2,090.00        $27,273.00        $29,363.00

                                            Additional          Existing
         05/01/98 -  12/31/98               1,155 rsf.       15,227 rsf.       16.382 rsf.
         -------------------------------------------------------------------------------- 

         Base Rent                           $1,455.00        $18,799.00        $20,254.00
         Op. Exp. (est. '96)                   $693.00        $ 9,137.00         $9,830.00
                                               -------        ----------         ---------
         Total Rent                          $2,148.00        $27,936.00        $30,084.00

                                            Additional          Existing
         01/01/99 - 04/30/99                1,155 rsf.       15,227 rsf.       16.382 rsf.
         ---------------------------------------------------------------------------------

         Base Rent                           $1,455.00        $18,937.00        $20,392.00
         Op. Exp. (est. '96)                   $693.00        $ 9,137,00         $9,830.00
                                               -------        ----------         ---------
         Total Rent                          $2,148.00        $28,074.00        $30,222.00

                                            Additional          Existing
         05/01/99 - 04/30/2000              1,155 rsf.       15,227 rsf.       16,382 rsf.
         ---------------------------------------------------------------------------------

         Base Rent                           $1,513.00        $19,600.00        $21,113.00
         Op. Exp. (est. '96)                   $693.00         $9,137.00         $9,830.00
                                               -------         ---------         ---------
         Total Rent                          $2,206.00        $28,737.00        $30,943.00
</TABLE>


4.       TENANT PROPORTIONATE SHARE

         Effective November 1, 1996, Tenant's proportionate share shall increase
         from 12.79% to 13.76%.

All  other  terms and  conditions  of the  original  Lease  Agreement  and Lease
Amendaments  #1 through #7 shall apply to this Lease  Amendment #8, as agreed to
this 26th day of August, 1996.

         LANDLORD:
         SPIEKER-SINGLETON #68 LIMITED PARTERSHIP
         A California Limited Partnership

         By:      Peter H. Schnugg
         Its:     Agent for Owner
         Date:    8/26/96

         TENANT:
         SCICLONE PHARMACEUTICALS, INC.
         A California Corporation

         By:      Mark A. Culhane
         Its:     Vice President Finance & Administration, CFO
         Date:    August 26, 1996


<TABLE> <S> <C>


<ARTICLE>                     5


<CIK>                         0000880771
<NAME>                        SciClone

       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                              DEC-31-1996
<PERIOD-START>                                 JUL-01-1996
<PERIOD-END>                                   SEP-30-1996
<CASH>                                         4,243,540
<SECURITIES>                                   33,791,905
<RECEIVABLES>                                  2,786,120
<ALLOWANCES>                                   0
<INVENTORY>                                    2,465,363
<CURRENT-ASSETS>                               17,642,181
<PP&E>                                         861,597
<DEPRECIATION>                                 (562,967)
<TOTAL-ASSETS>                                 45,698,450
<CURRENT-LIABILITIES>                          4,210,347
<BONDS>                                        0
<COMMON>                                       0
                          0
                                    109,580,480
<OTHER-SE>                                     (68,092,377)
<TOTAL-LIABILITY-AND-EQUITY>                   45,698,450
<SALES>                                        400,603
<TOTAL-REVENUES>                               400,603
<CGS>                                          555,156
<TOTAL-COSTS>                                  555,156
<OTHER-EXPENSES>                               13,101,857
<LOSS-PROVISION>                               0
<INTEREST-EXPENSE>                             0
<INCOME-PRETAX>                                (11,239,467)
<INCOME-TAX>                                   (859)
<INCOME-CONTINUING>                            (11,240,326)
<DISCONTINUED>                                 0
<EXTRAORDINARY>                                0
<CHANGES>                                      0
<NET-INCOME>                                   (11,240,326)
<EPS-PRIMARY>                                  (0.65)
<EPS-DILUTED>                                  0
        


</TABLE>


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