SCICLONE PHARMACEUTICALS INC
DEF 14A, 1997-04-22
PHARMACEUTICAL PREPARATIONS
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                        SCHEDULE 14A INFORMATION
            PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE
                    SECURITIES EXCHANGE ACT OF 1934
                     (Amendment No. ______________)


Filed by the Registrant    /X/
Filed by a party other than the Registrant   / /

Check the appropriate box:
/ /  Preliminary proxy statement
/ /  Confidential, for use of the Commission only (as permitted by
     Rule 14a-6(e)(2))
/X/  Definitive proxy statement
/ /  Definitive additional materials
/ /  Soliciting material pursuant to Sec. 240.14a-11(c) or Sec. 240.14a-12

                         SCICLONE PHARMACEUTICALS, INC.
                ------------------------------------------------
                (Name of Registrant as Specified in Its Charter)


    ------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of filing fee (Check the appropriate box):

/X/  No fee required.
     

/ /  $500 per each party to the controversy pursuant to Exchange Act Rule
     14a-6(i)(3).

/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.


(1)  Title of each class of securities to which transactions applies:

- ----------------------------------------------------------------------------

(2)  Aggregate number of securities to which transactions applies:

- ----------------------------------------------------------------------------

(3)  Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing
fee is calculated and state how it was determined):

- ----------------------------------------------------------------------------

(4)  Proposed maximum aggregate value of transaction:

- ----------------------------------------------------------------------------

(5)  Total fee paid:

- ----------------------------------------------------------------------------

/ /  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act
     Rule 0-11(a)(2) and identify the filing for which the offsetting fee
     was paid previously.  Identify the previous filing by registration
     statement number, or the Form or Schedule and the date of its filing.

(1)  Amount previously paid:

- ----------------------------------------------------------------------------

(2)  Form, Schedule or Registration Statement No.:

- ----------------------------------------------------------------------------

(3)  Filing party:

- ----------------------------------------------------------------------------

(4)  Date filed:

- ----------------------------------------------------------------------------



<PAGE>
                         SCICLONE PHARMACEUTICALS, INC.
                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                             TO BE HELD MAY 16, 1997

   The  Annual  Meeting of  Shareholders  (the  "Annual  Meeting")  of  SciClone
Pharmaceuticals, Inc., a California corporation (the "Company"), will be held at
the Hotel Sofitel,  233 Twin Dolphin Drive,  Redwood City,  California 94065, on
Friday, May 16, 1997, at 9:00 a.m., local time, for the following  purposes:

      1. To elect five (5)  directors  of the  Company  to serve  until the 1997
   Annual  Meeting of  Shareholders  or until their  respective  successors  are
   elected and qualified;

      2. To approve an amendment to the Company's 1995 Equity  Incentive Plan to
   increase by 750,000 the maximum  number of shares of Common Stock that may be
   issued under such plan.

      3. To  ratify  the  appointment  of Ernst & Young  LLP as the  independent
   auditors for the Company for the year ending December 31, 1997; and

      4. To transact such other  business as may properly come before the Annual
   Meeting and any adjournment or postponement thereof.

   The foregoing  items of business,  including the nominees for directors,  are
more fully described in the Proxy Statement which is attached and made a part of
this Notice.

   The Board of  Directors  has fixed the close of business on April 14, 1997 as
the record date for  determining the  shareholders  entitled to notice of and to
vote at the Annual Meeting and any adjournment or postponement thereof.

   All  shareholders  are  cordially  invited to attend  the  Annual  Meeting in
person.  However,  whether or not you  expect to attend  the  Annual  Meeting in
person,  you are urged to mark, sign, date and return the enclosed proxy card as
promptly  as possible in the  postage-prepaid  envelope  provided to ensure your
representation  and the presence of a quorum at the Annual Meeting.  If you send
in your  proxy card and then  decide to attend  the Annual  Meeting to vote your
shares in person,  you may still do so. Your proxy is  revocable  in  accordance
with the procedures set forth in the Proxy Statement.


                              By Order of the Board of Directors,

                              /s/ Mark A. Culhane


                              MARK A. CULHANE
                              Secretary


San Mateo, California
April 18, 1997

<PAGE>
                         SCICLONE PHARMACEUTICALS, INC.
                          901 MARINERS ISLAND BOULEVARD
                           SAN MATEO, CALIFORNIA 94404

                                 PROXY STATEMENT

GENERAL

   This Proxy Statement is furnished in connection with the  solicitation by the
Board of Directors (the "Board") of SciClone Pharmaceuticals, Inc., a California
corporation (the  "Company"),  of proxies in the enclosed form for use in voting
at the Annual Meeting of Shareholders  (the "Annual  Meeting") to be held at the
Hotel  Sofitel,  233 Twin Dolphin  Drive,  Redwood City,  California  94065,  on
Friday,  May 16,  1997,  at 9:00  a.m.,  local  time,  and  any  adjournment  or
postponement thereof.

   This Proxy Statement, the enclosed proxy card and the Company's Annual Report
to Shareholders are being mailed to shareholders on or about April 18, 1997.

REVOCABILITY OF PROXIES

   Any proxy given  pursuant to this  solicitation  may be revoked by the person
giving it at any time before its use by  delivering  to the Company  (Attention:
Mark A. Culhane) a written notice of revocation or a duly executed proxy bearing
a later date, or by attending the Annual Meeting and voting in person.

RECORD DATE

   The close of  business  on April 14,  1997 has been fixed as the record  date
(the "Record Date") for determining the holders of shares of Common Stock of the
Company entitled to notice of and to vote at the Annual Meeting. At the close of
business on the Record Date, the Company had approximately  17,498,970 shares of
Common Stock outstanding.

VOTING AND SOLICITATION

   Each outstanding  share of Common Stock on the Record Date is entitled to one
vote on all  matters  and is  entitled  to  cumulate  votes for the  election of
directors, subject to the conditions described below.

   Votes cast by proxy or in person at the Annual  Meeting  will be tabulated by
the Inspector of Elections with the assistance of the Company's  transfer agent.
The  Inspector  of  Elections  will also  determine  whether  or not a quorum is
present.  Except with respect to the election of directors and except in certain
other  specific  circumstances,  the  affirmative  vote of a majority  of shares
represented  and  voting at a duly  held  meeting  at which a quorum is  present
(which shares voting  affirmatively  also  constitute at least a majority of the
required  quorum) is required  under  California  law for  approval of proposals
presented to  shareholders.  In general,  California  law also  provides  that a
quorum consists of a majority of the shares entitled to vote, represented either
in person or by proxy.  The  Inspector of Elections  will treat  abstentions  as
shares that are present and  entitled to vote for  purposes of  determining  the
presence of a quorum but as not voting for purposes of determining  the approval
of any matter submitted to the shareholders for a vote.


   The shares  represented by the proxies  received,  properly  marked,  signed,
dated and not revoked  will be voted at the Annual  Meeting.  Where such proxies
specify a choice with respect to any matter to be acted upon, the shares will be
voted in accordance with the specifications made. Any proxy in the enclosed form
which is returned but is not marked will be voted FOR the election of directors,
the FOR amendment of the Option Plan, FOR ratification of the appointment of the
designated independent auditors and as the proxy holders deem advisable on other
matters that may come before the meeting, as the case may be with respect to the
item not marked.  If a broker  indicates on the enclosed proxy or its substitute
that it does not have discretionary  authority as to certain shares to vote on a
particular matter ("broker  non-votes"),  those shares will not be considered as
voting  with  respect to that  matter.  While  there is no  definitive  specific
statutory or case law authority in California concerning the proper treatment of
abstentions  and broker  non-votes,  the Company  believes  that the  tabulation
procedures to be followed by the Inspector of Elections are consistent  with the
general  statutory  requirements in California  concerning  voting of shares and
determination of a quorum. 

                                1
<PAGE>
   The  solicitation  of proxies  will be conducted by mail and the Company will
bear all attendant costs.  These costs will include the expense of preparing and
mailing proxy  solicitation  materials for the Annual Meeting and reimbursements
paid to brokerage  firms and others for their  expenses  incurred in  forwarding
solicitation  materials regarding the Annual Meeting to beneficial owners of the
Company's Common Stock. The Company may conduct further solicitation personally,
telephonically  or by facsimile  through its officers,  directors and employees,
none of whom  will  receive  additional  compensation  for  assisting  with  the
solicitation.

                                 PROPOSAL NO. 1
                              ELECTION OF DIRECTORS

NOMINEES

   At the Annual Meeting,  the  shareholders  will elect five directors to serve
until  the  1997  Annual  Meeting  of  Shareholders  or until  their  respective
successors  are  elected  and  qualified.  In the event any nominee is unable or
unwilling to serve as a director at the time of the Annual Meeting,  the proxies
may be voted for the  balance  of those  nominees  named and for any  substitute
nominee  designated  by the  present  Board or the  proxy  holders  to fill such
vacancy,  or for the  balance of the  nominees  named  without  nomination  of a
substitute,  or the Board may be  reduced in  accordance  with the Bylaws of the
Company.  The Board has no reason to believe that any of the persons named below
will be unable or unwilling to serve as a nominee or as a director if elected.

   In voting for directors,  each shareholder is entitled to cast that number of
votes equal to the number of directors to be elected multiplied by the number of
shares of Common Stock held by such shareholder.  Such votes may be cast for one
candidate  or  distributed  in any  manner  among the  nominees  for  directors.
However,  the right to cumulate votes in favor of one or more candidates may not
be exercised unless the candidate or candidates have been nominated prior to the
voting,  and a shareholder has given notice at the Annual Meeting,  prior to the
voting, of the shareholder's  intention to cumulate such shareholder's votes. If
any one shareholder gives such notice, all shareholders may cumulate their votes
for candidates in nomination.  The persons authorized to vote shares represented
by executed  proxies in the enclosed form (if authority to vote for the election
of directors is not withheld)  will have full  discretion  and authority to vote
cumulatively  and to allocate votes among any or all of the nominees as they may
determine or, if authority to vote for a specified  candidate or candidates  has
been  withheld,  among those  candidates for whom authority to vote has not been
withheld.

   Assuming a quorum is present,  the five nominees receiving the highest number
of affirmative  votes of shares entitled to be voted for them will be elected as
directors of the Company for the ensuing year. Unless marked otherwise,  proxies
received  will be voted  FOR the  election  of each of the five  nominees  named
below.  In the event that  additional  persons  are  nominated  for  election as
directors, the proxy holders intend to vote all proxies received by them in such
a manner in accordance with cumulative  voting as will ensure the election of as
many of the nominees listed below as possible,  and, in such event, the specific
nominees to be voted for will be determined by the proxy holders.

   The names of the nominees,  their ages as of April 1, 1997, and certain other
information about them are set forth below:

                                                                     DIRECTOR  
    NAME OF NOMINEE          AGE         PRINCIPAL OCCUPATION         SINCE
- -------------------------  ----- ---------------------------------- ----------
Donald R. Sellers  ......    52  President, Chief Executive Officer   1996
                                 and Director                         
Thomas E. Moore .........    53  Chairman of the Board of Directors   1990
                                 of the Company                       
John D. Baxter, M.D......    56  Professor of Medicine                1991
Edwin C. Cadman, M.D.....    51  Professor of Medicine                1991
Jere E. Goyan, Ph.D......    66  President and Chief Operating        1992
                                 Officer of Alteon, Inc.            
                           
                                        2
<PAGE>                  

   There are no family  relationships  among any of the  directors  or executive
officers of the Company.

   Donald  Sellers has served as the  Company's  President  and  Director  since
January 1996 and its Chief Executive  Officer since April 1996. From May 1993 to
present,  he has also  served as  Managing  Director,  SciClone  Pharmaceuticals
International Ltd., the international arm of the Company. From 1990 to 1993, Mr.
Sellers was Corporate Vice President of Getz Bros., an Asian trading company, as
well as President of their  Japanese  operation.  From 1983 to 1990, Mr. Sellers
was employed by Sterling  Drug  International,  initially  as Vice  President of
Marketing  and  Operations  in Asia and  beginning in 1985 as Vice  President of
Business  Development  for Latin America and in 1987 as President of their Latin
American Andina Group. Mr. Sellers began his pharmaceutical  career in 1973 with
Pfizer as Country  Manager,  Vietnam and Hong Kong, and he later worked with the
Revlon  Healthcare  Group as Director  of  Worldwide  Exports  and Pacific  Area
Director.

   Thomas E.  Moore,  a founder of the  Company,  has  served as a director  and
Chairman of the Board of Directors  of the Company  since its  inception  and as
Chief Executive  Officer of the Company from August 1991 to April 1, 1996. Since
February  1995, Mr. Moore has also served as Chairman of the Board of Cord Blood
Registry,  Inc., a cord blood banking  company.  Since 1988,  Mr. Moore has also
served as a principal in Sand Hill  Management  Group, a private  investment and
management firm specializing in the computer software, medical and biotechnology
industries.  From  1982 to 1988,  Mr.  Moore  was the  Chairman  of the Board of
Directors of Synercom Technology,  Inc. ("Synercom"),  a software company. Prior
to  Synercom,  Mr.  Moore was Vice  President  of  Pacific  Operations  and Vice
President of Strategic Planning at Honeywell, Inc., an electronics company.

   John D.  Baxter,  M.D.  has been a director  and  Chairman of its  Scientific
Advisory Board in June 1991. Dr. Baxter has been  associated with the University
of California, San Francisco since 1970. He has been Professor of Medicine since
1979,  Chief of the  Endocrinology  Section,  Parnassus  Campus  since  1980 and
Director of the Metabolic Research Unit since 1981. Dr. Baxter was a founder and
served as a director  of Scios  Nova Inc.,  a  biotechnology  company,  from its
inception in 1982 to 1991.

   Edwin C.  Cadman,  M.D.  has been a  director  and  member  of the  Company's
Scientific  Advisory Board since  November 1991.  Since January 1994, Dr. Cadman
has been Senior Vice President of Medical Affairs and Chief of Staff at Yale New
Haven  Hospital,  where he was Chief of the Medical  Service  from 1987  through
December  1993.  Since 1987,  Dr. Cadman has also been  Professor of Medicine at
Yale  University,  where he was Chairman of the Department of Medicine from 1987
through December 1993.  Prior to these positions,  he was Director of the Cancer
Research  Institute at the University of California,  San Francisco.  Dr. Cadman
also currently serves as a director of  CytoTherapeutics,  Inc., a biotechnology
company.

   Jere E. Goyan,  Ph.D.  has been a director of the Company since January 1992.
Since July 1993,  Dr. Goyan has been President and Chief  Operating  Officer and
director of Alteon, Inc., a biotechnology company where he served as Senior Vice
President for Research and  Development  from January 1993 through July 1993 and
as Acting Chief Executive Officer from July 1993 through May 1994. Dr. Goyan was
Dean of the School of Pharmacy  and  Professor  of Pharmacy  and  Pharmaceutical
Chemistry at the University of California, San Francisco from 1967 through 1992,
and was a Professor  there from 1965 through 1992.  From 1979 to 1981, Dr. Goyan
was the  Commissioner  of the United  States Food and Drug  Administration.  Dr.
Goyan also currently  serves as a director of Emisphere  Technologies,  Inc. and
Atrix  Laboratories,  both  biotechnology  companies,  and  Boehringer  Mannheim
Pharmaceuticals Corporation.

MEETINGS AND COMMITTEES OF THE BOARD OF DIRECTORS

   During 1996, the Board met four times and no director attended fewer than 75%
of the aggregate  number of meetings of the Board and meetings of the committees
of the  Board on which he  serves.  The  Board  has two  committees:  the  Audit
Committee and the Compensation  Committee.  The Board does not have a nominating
committee or a committee  performing  the  functions of a nominating  committee.
Although there are no formal  procedures for shareholders to nominate persons to
serve as directors, the Board will consider nominations from shareholders, which
should be  addressed  to Mark A.  Culhane,  at the  Company's  address set forth
above.

                                        3
<PAGE>

   The Audit Committee consists of directors Cadman and Goyan, the Company's two
non-employee  directors,  and held one meeting during 1996. The Audit  Committee
recommends the engagement of the firm of certified  public  accountants to audit
the financial  statements of the Company,  and monitors the effectiveness of the
audit effort, the Company's financial and accounting organization and its system
of internal accounting controls.

   The  Compensation  Committee,  which also  consists of  directors  Cadman and
Goyan,  held three  meeting(s)  during 1996.  Its functions are to establish and
administer the Company's  policies  regarding annual executive salaries and cash
incentives  and  long-term  equity   incentives.   The  Compensation   Committee
administers  the Company's 1991 and 1992 Stock Plans,  the Company's 1995 Equity
Incentive Plan and the Company's 1995 Nonemployee Director Stock Option Plan.

COMPENSATION OF DIRECTORS

   Directors  who are  employees of the Company do not receive any  compensation
for their services as directors.  Directors who are not employees of the Company
receive an annual retainer of $12,000,  payable at the rate of $1,000 per month,
plus  payment  of  out-of-pocket  expenses  relating  to their  service as Board
members.

   The Company has entered into a consulting  agreement with Dr. Baxter pursuant
to which Dr.  Baxter  serves as Chairman of the  Company's  Scientific  Advisory
Board and performs  consulting  services as requested by the Company.  Under the
agreement,  Dr. Baxter  receives a fee of $6,000 per month.  Dr. Baxter received
$72,000  under this  agreement in 1996.  The Company has retained Dr.  Cadman to
perform  consulting  services,  principally  analysis  of  drug  candidates  for
licensing  or  acquisition.  Dr.  Cadman  receives a fee of $6,250 per month for
these services.  Dr. Cadman received  $75,000 in such fees in 1996. From time to
time,  Dr. Goyan  performs  consulting  services  for the  Company.  The Company
compensates  Dr.  Goyan  for  these  services  at his  then-effective  rate  for
consulting  services.  Dr.  Goyan did not receive any  consulting  fees from the
Company in 1996.

   Messrs. Baxter, Cadman and Goyan will each receive options to purchase 10,000
shares of the  Company's  Common  Stock  under the  Company's  1995  Nonemployee
Director  Stock  Option  Plan if they are  reelected  to the Board at the Annual
Meeting.  Each such option shall be exercisable in full or part to the extent of
one-twelfth  of the shares  subject  to the option at the end of each  one-month
period thereafter.

RECOMMENDATION OF THE BOARD

                         THE BOARD RECOMMENDS A VOTE FOR
                    THE ELECTION OF ALL NOMINEES NAMED ABOVE.

                                        4
<PAGE>

                                 PROPOSAL NO. 2
                   AMENDMENT OF THE 1995 EQUITY INCENTIVE PLAN

GENERAL

   At the Annual Meeting, the shareholders will be asked to approve an amendment
to the Company's  1995 Equity  Incentive Plan (the "Option Plan") to increase by
750,000 the maximum  number of shares of Common  Stock that may be issued  under
the Option Plan.

   The  Company's  shareholders  have  previously  approved the  reservation  of
1,250,000  shares of the  Company's  Common Stock  (subject to  adjustment  upon
certain  changes in the  capital  structure  of the  Company)  for  issuance  to
employees (including officers)and consultants under the Option Plan. As of March
31, 1997,  options to purchase an  aggregate  of 674,900  shares of Common Stock
were  outstanding,  at a weighted average exercise price of $7.13 per share, and
2,194 shares had been issued upon the exercise of  previously  granted  options,
leaving 572,906 shares available for future option grants. To enable the Company
to continue to provide long-term equity  incentives,  the Board of Directors has
amended the Option Plan,  subject to approval by the  shareholders,  to increase
the maximum number of shares that may be issued under the Option Plan by 750,000
to an aggregate of 2,000,000 shares.

   The Board of Directors believes that the Company's stock option program is an
important  factor  in  attracting  and  retaining  the high  caliber  employees,
directors  and  consultants  essential  to the  success  of the  Company  and in
aligning  their  long-term  interests  with those of the  shareholders.  Because
competition  for highly  qualified  individuals  in the  Company's  industry  is
intense,  management believes that to successfully  attract the best candidates,
the  Company  must offer a  competitive  stock  option  program as an  essential
component of its compensation  packages. The Board of Directors further believes
that stock  options  serve an  important  role in  motivating  their  holders to
contribute to the Company's  continued  growth and  profitability.  The proposed
amendment  is  intended  to ensure  that the Option  Plan will  continue to have
available a reasonable number of shares to meet these needs.

SUMMARY OF THE OPTION PLAN, AS AMENDED

   The  following  summary of the Option Plan,  as amended,  is qualified in its
entirety  by the  specific  language  of the  Option  Plan,  a copy of  which is
available to any shareholder upon request.

   General.  The purpose of the Option Plan is to advance the  interests  of the
Company and its  shareholders  by providing an incentive to attract,  retain and
reward the Company's employees, directors and consultants and by motivating such
persons to contribute to the Company's growth and profitability. It provides for
the grant of incentive  stock  options  within the meaning of section 422 of the
Code and nonqualified stock options.

   Shares  Subject to Plan.  The  shareholders  have  previously  authorized  an
aggregate of 1,250,000  shares of the  Company's  Common Stock for issuance upon
the exercise of options  granted under the Option Plan.  As amended,  the Option
Plan would provide that the maximum  aggregate number of authorized but unissued
or  reacquired  shares of  Common  Stock  that may be  issued  under the plan is
2,000,000.  Appropriate  adjustments  will be made to the shares  subject to the
Option Plan, and to outstanding  options upon any stock  dividend,  stock split,
reverse stock split,  combination,  reclassification,  or similar  change in the
capital  structure of the  Company.  To the extent that any  outstanding  option
under the Option  Plan  expires or  terminates  prior to  exercise in full or if
shares issued upon  exercise of an option are  repurchased  by the Company,  the
shares of Common Stock for which such option is not exercised or the repurchased
shares are returned to the Option Plan and become available for future grant.

   Administration.  The Option Plan is administered by the Board of Directors or
a  duly  appointed  committee  of  the  Board  (hereinafter  referred  to as the
"Board"). Subject to the provisions of the Option Plan, the Board determines the
persons to whom options are to be granted, the number of shares to be covered by
each  option,  whether  an  option  is to  be an  incentive  stock  option  or a
nonqualified stock option, the timing and terms of exercisability and vesting of
each option,  the exercise price of and the type of  consideration to be paid to
the Company upon the exercise of each option,  the duration of each option,  and
all other terms and  conditions  of the options.  The Board will  interpret  the
Option Plan and options granted thereunder,  and all determinations of the Board
will be final and binding on all  persons  having an interest in the Option Plan
or any option.

                                        5
<PAGE>

   Eligibility.  Options  may be  granted  under the  Option  Plan to  employees
(including officers), and consultants of the Company or of any present or future
parent or  subsidiary  corporations  of the Company.  As of March 31, 1997,  the
Company had approximately 38 employees,  including 3 executive  officers.  While
any person  eligible under the Option Plan may be granted a  nonqualified  stock
option, only employees may be granted incentive stock options.

   Terms and Conditions of Options. Each option granted under the Option Plan is
evidenced by a written agreement between the Company and the optionee specifying
the number of shares subject to the option and the other terms and conditions of
the option,  consistent with the requirements of the plan. The exercise price of
each  incentive  stock option granted under the Option Plan may not be less than
the fair market  value of a share of the  Company's  Common Stock on the date of
grant,  while the exercise price of a  nonqualified  stock option may be greater
than, equal to or less than such fair market value. However, any incentive stock
option granted to a person who at the time of grant owns stock  possessing  more
than 10% of the  total  combined  voting  power of all  classes  of stock of the
Company or any parent or subsidiary  corporation  of the Company (a "Ten Percent
Shareholder")  must have an  exercise  price  equal to at least 110% of the fair
market  value of a share of Common  Stock on the date of grant.  As of March 31,
1997, the closing price of the Company's Common Stock, as reported on the Nasdaq
National Market, was $6.563 per share.

   The  option  exercise  price  may be  paid  in  cash,  by  check,  or in cash
equivalent,  by  tender of shares of the  Company's  Common  Stock  owned by the
optionee  having a fair market  value not less than the exercise  price,  by the
assignment  of the  proceeds  of a sale of some or all of the  shares  of Common
Stock being  acquired upon the exercise of the option,  by means of a promissory
note, or by any combination of these.  The Board may  nevertheless  restrict the
forms of payment permitted in connection with any option grant. No option may be
exercised until the optionee has made adequate provision for federal,  state and
foreign taxes, if any, relating to the exercise of the option.

   Options  granted under the Option Plan become  exercisable and vested at such
times and subject to such conditions as specified by the Board. The maximum term
of an option granted under the Option Plan is ten years, provided that an option
granted to a Ten Percent  Shareholder must have a term not exceeding five years.
Generally, options granted under the Option Plan become exercisable in full four
years after the date of grant,  subject to the optionee's continued service with
the Company, and have a term of ten years.

   Incentive  stock options are  nontransferable  by the optionee  other than by
will or by the laws of descent and distribution,  and are exercisable during the
optionee's  lifetime only by the  optionee.  Nonqualified  stock option  granted
under the Option Plan may be assigned or transferred to the extent  permitted by
the Board and set forth in the option agreement.  Options remain exercisable for
three  months  following  an  optionee's  termination  of  service,  unless such
termination  results from the optionee's death or disability,  in which case the
option  will remain  exercisable  for twelve  months  following  the  optionee's
termination of service,  provided that in any event the option must be exercised
no later than its expiration date.

   Change in Control. The Option Plan provides that in the event of (i) a merger
or  consolidation in which the Company is a party or the direct or indirect sale
or exchange by the  shareholders  of all or  substantially  all of the Company's
stock wherein,  upon any such event, the shareholders of the Company immediately
before such event do not retain, directly or indirectly,  at least a majority of
the  beneficial  interest in the voting  stock of the Company or its  successor,
(ii) the sale, exchange or transfer of all or substantially all of the assets of
the Company,  or (iii) a liquidation or dissolution of the Company (a "Change in
Control"),  the  acquiring or successor  corporation  must assume the  Company's
rights and obligations  under the outstanding  options or substitute new options
for such corporation's  stock. To the extent that the options  outstanding under
the Option Plan are not assumed,  replaced,  or exercised prior to the Change in
Control, they will terminate.

   Termination  or  Amendment.  The Option Plan will  continue  in effect  until
January __, 2005 unless earlier terminated by the Board. The Board may terminate
or amend the Option Plan at any time. However, without shareholder approval, the
Board may not amend the Option Plan to increase the total

                                        6
<PAGE>

number of shares of Common  Stock  issuable  thereunder  or change  the class of
persons eligible to receive  options.  No termination or amendment may adversely
affect an  outstanding  option  without the consent of the optionee,  unless the
amendment  is required to preserve the  option's  status as an  incentive  stock
option.

SUMMARY OF UNITED STATES FEDERAL INCOME TAX CONSEQUENCES

   The  following  summary is intended  only as a general guide as to the United
States federal income tax consequences under current law of participation in the
Option Plan and does not attempt to describe all  possible  federal or other tax
consequences  of such  participation  or tax  consequences  based on  particular
circumstances.

   Incentive Stock Options. An optionee recognizes no taxable income for regular
income tax purposes as the result of the grant or exercise of an incentive stock
option qualifying under section 422 of the Code. Optionees who do not dispose of
their shares for two years  following the date the option was granted nor within
one year  following  the  exercise  of the  option  will  normally  recognize  a
long-term capital gain or loss equal to the difference, if any, between the sale
price and the  purchase  price of the  shares.  If an  optionee  satisfies  such
holding  periods upon a sale of the shares,  the Company will not be entitled to
any deduction for federal income tax purposes. If an optionee disposes of shares
within  two years  after  the date of grant or within  one year from the date of
exercise (a "disqualifying disposition"), the difference between the fair market
value  of  the  shares  on  the   determination   date  (see  discussion   under
"Nonqualified Stock Options" below) and the option exercise price (not to exceed
the gain realized on the sale if the  disposition is a transaction  with respect
to which a loss, if sustained,  would be  recognized)  will be taxed as ordinary
income at the time of  disposition.  Any gain in excess of that amount will be a
capital gain. If a loss is  recognized,  there will be no ordinary  income,  and
such loss will be a capital  loss.  A capital  gain or loss will be long-term if
the  optionee's  holding  period is more than 12  months.  Any  ordinary  income
recognized  by the optionee  upon the  disqualifying  disposition  of the shares
generally  should be deductible by the Company for federal  income tax purposes,
except to the extent such  deduction is limited by applicable  provisions of the
Code or the regulations thereunder.

   The difference between the option exercise price and the fair market value of
the  shares  on  the  determination  date  of an  incentive  stock  option  (see
discussion  under  "Nonqualified  Stock  Options"  below)  is an  adjustment  in
computing the optionee's  alternative  minimum taxable income and may be subject
to an alternative  minimum tax which is paid if such tax exceeds the regular tax
for the year.  Special rules may apply with respect to certain  subsequent sales
of the shares in a  disqualifying  disposition,  certain basis  adjustments  for
purposes of computing the  alternative  minimum  taxable  income on a subsequent
sale of the shares  and  certain  tax  credits  which may arise with  respect to
optionees subject to the alternative minimum tax.

   Nonqualified Stock Options. Options not designated or qualifying as incentive
stock options will be  nonqualified  stock options.  Nonqualified  stock options
have no special tax status. An optionee  generally  recognizes no taxable income
as the result of the grant of such an option.  Upon  exercise of a  nonqualified
stock option, the optionee normally  recognizes ordinary income in the amount of
the  difference  between the option  exercise price and the fair market value of
the shares on the  determination  date (as defined below). If the optionee is an
employee, such ordinary income generally is subject to withholding of income and
employment  taxes. The  "determination  date" is the date on which the option is
exercised  unless the shares are subject to a substantial risk of forfeiture and
are not transferable, in which case the determination date is the earlier of (i)
the date on which  the  shares  are  transferable  or (ii) the date on which the
shares are not subject to a substantial risk of forfeiture. If the determination
date is after the exercise  date,  the  optionee may elect,  pursuant to section
83(b) of the Code, to have the exercise date be the determination date by filing
an election with the Internal  Revenue  Service not later than 30 days after the
date the option is exercised. Upon the sale of stock acquired by the exercise of
a nonqualified  stock option,  any gain or loss, based on the difference between
the sale price and the fair  market  value on the  determination  date,  will be
taxed as capital  gain or loss.  A capital gain or loss will be long-term if the
optionee's  holding period is more than 12 months. No tax deduction is available
to the Company with respect to the grant of a  nonqualified  stock option or the
sale of the stock acquired pursuant to such grant. The Company

                                        7
<PAGE>

generally  should be  entitled  to a  deduction  equal to the amount of ordinary
income  recognized by the optionee as a result of the exercise of a nonqualified
stock  option,  except to the extent  such  deduction  is limited by  applicable
provisions of the Code or the regulations thereunder.

CHANGES TO BENEFIT PLAN

   The Board of Directors  has amended the Option Plan,  subject to  stockholder
approval,  to increase the maximum aggregate number of the Company's shares that
may be issued  under the Option Plan from  1,250,000  shares of common  stock to
2,000,000  shares.  No  option  grants  have been made  under  the  Option  Plan
following  this  amendment.  Future grants under the Option Plan will be made at
the discretion of the Board,  and,  accordingly,  are not yet  determinable.  In
addition,  benefits  under the Option  Plan will  depend on a number of factors,
including  the fair market value of the  Company's  common stock on future dates
and, in the case of stock options, the exercise decisions made by the optionees.
Consequently it is not possible to determine the benefits that might be received
by participants in the Option Plan.

   During the fiscal year ended  December  31,  1996,  (1) the  Company's  Chief
Executive Officers and two other executive officers whose total salary and bonus
for the fiscal year ended  December 31, 1996 exceeded  $100,000  received  stock
option grants to purchase  440,500 shares of common stock under the Option Plan;
(2) all current  executive  officers as a group  received stock option grants to
purchase  440,500  shares of common stock under the Option Plan; (3) all current
directors who are not executive officers as a group received stock option grants
to purchase  30,000  shares of common stock under this Option  Plan;  (4) Donald
Sellers,  Thomas E.  Moore,  John D.  Baxter,  Edwin C. Cadman and Jere E. Goyan
received stock option grants to purchase 400,000,  0, 10,000,  10,000 and 10,000
shares of common stock, respectively, under the Option Plan; (5) no associate of
any director,  executive  officer or nominee received any stock option grants to
purchase  shares of common  stock under the Option  Plan;  (6) Donald R. Sellers
received a grant to  purchase  400,000  shares of common  stock under the Option
Plan,  or 45.9% of all  options  granted  under  the  Option  Plan;  and (7) all
employees,  including all current  officers who are not executive  officers as a
group  received  stock option grants to purchase  231,350 shares of common stock
under the Option Plan.

REQUIRED VOTE

   The affirmative vote of a majority of the votes cast at the Annual Meeting of
Shareholders,  at which a quorum  representing  a  majority  of all  outstanding
shares of Common Stock of the Company is present and voting, either in person or
by proxy,  is required for  approval of this  proposal.  Abstentions  and broker
non-votes  will each be counted as  present  for  purposes  of  determining  the
presence  of a  quorum,  but will not be  counted  as having  been  voted on the
proposal.

RECOMMENDATION OF THE BOARD

            THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR
             AMENDMENT OF THE OPTION PLAN TO INCREASE BY 750,000 THE
                    MAXIMUM NUMBER OF SHARES OF COMMON STOCK
                         ISSUABLE UNDER THE OPTION PLAN.

                                        8
<PAGE>

                                 PROPOSAL NO. 3
               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS

   Ernst & Young LLP has served as the Company's independent auditors since 1991
and has been  appointed  by the Board to continue as the  Company's  independent
auditors for the year ending  December 31, 1997. In the event that  ratification
of this  selection  of auditors  is not  approved by a majority of the shares of
Common Stock voting at the Annual Meeting in person or by proxy, management will
review its future selection of auditors.

   A representative of Ernst & Young LLP is expected to be present at the Annual
Meeting.  This  representative  will have an opportunity to make a statement and
will be available to respond to appropriate questions.

RECOMMENDATION OF THE BOARD

               THE BOARD RECOMMENDS A VOTE FOR RATIFICATION OF THE
                APPOINTMENT OF ERNST & YOUNG LLP AS THE COMPANY'S
           INDEPENDENT AUDITORS FOR THE YEAR ENDING DECEMBER 31, 1997

           STOCK OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

   The  following  table sets forth  information  that has been  provided to the
Company with respect to beneficial  ownership of shares of the Company's  Common
Stock as of the March 31,  1997 for (i) each  person who is known by the Company
to own beneficially more than 5% of the outstanding shares of Common Stock, (ii)
each of the Named  Executive  Officers,  (iii) each  director of the Company and
(iv) all directors and executive officers of the Company as a group.

                                                  SHARES BENEFICIALLY
                                                       OWNED(1)
                                                ---------------------
                      NAME                         NUMBER     PERCENT
- ----------------------------------------------- ----------- ---------
Thomas E. Moore(2) .............................  3,317,381   18.7%
John D. Baxter, M.D.(3) ........................    413,839    2.4%
Donald R. Sellers(4) ...........................    301,933    1.7%
David L. Horwitz, M.D., Ph.D.(5) ...............    289,721    1.6%
Mark A. Culhane(6) .............................    204,692    1.2%
Edwin C. Cadman, M.D.(7) .......................     49,813     *
Jere E. Goyan, Ph.D.(8) ........................     48,333     *
All directors and executive officers as a group   
 (7 persons)(9) ................................  4,625,712   24.8%
                                                  
- -------------------
* Less than 1%.

(1)  Except pursuant to applicable community property laws, the Company believes
     the persons named in the table have sole voting and  investment  power with
     respect to all shares.

(2)  Includes  2,243,167 shares held of record by Sand Hill Management  Group, a
     sole  proprietorship  of which Mr. Moore is the  principal,  308,616 shares
     held of record by Moore  Family  Limited  Partnership  and  200,000  shares
     issuable pursuant to options exercisable within 60 days of March 31, 1997.

(3)  Includes 18,333 shares issuable pursuant to options  exercisable  within 60
     days of March 31, 1997.

(4)  Includes 297,933 shares issuable pursuant to options  exercisable within 60
     days of March 31, 1997.

(5)  Includes 252,054 shares issuable pursuant to options  exercisable within 60
     days of March 31, 1997.

(6)  Includes 189,227 shares issuable pursuant to options  exercisable within 60
     days of March 31, 1997.

(7)  Consists of 48,813 shares issuable pursuant to options  exercisable  within
     60 days of March 31, 1997.

(8)  Includes 48,333 shares issuable pursuant to options  exercisable  within 60
     days of March 31, 1997.

(9)  Includes  1,054,693 shares issuable pursuant to options  exercisable within
     60 days of March 31, 1997.

                                        9
<PAGE>

                            EXECUTIVE COMPENSATION
<TABLE>

   The following table sets forth certain information concerning compensation of
(i) the  Company's  Chief  Executive  Officer  and (ii) the two other  executive
officers of the Company serving at December 31, 1996  (collectively,  the "Named
Executive Officers").

                           SUMMARY COMPENSATION TABLE
<CAPTION>
                                                                             LONG TERM
                                                                            COMPENSATION
                                           ANNUAL COMPENSATION                 AWARDS
                              ------------------------------------------- --------------
                                                                             SECURITIES
                                                             OTHER ANNUAL    UNDERLYING     ALL OTHER
                                        SALARY               COMPENSATION   OPTIONS/SARS   COMPENSATION
 NAME AND PRINCIPAL POSITION    YEAR    ($)(2)    BONUS ($)      ($)            (#)            ($)
- ----------------------------- ------ ----------- --------- -------------- -------------- --------------
<S>                             <C>    <C>         <C>       <C>              <C>          <C>
Donald R. Sellers(1)            1996   400,000     150,000         *          400,000       8,524 (6)
 President and Chief            1995   203,643      78,180   328,854 (3)       60,000      13,522 (6)
 Executive Officer              1994   194,506     120,000   306,927 (3)       40,000      10,428 (6)
David L. Horwitz, M.D., Ph.D.   1996   234,000      81,800    92,193 (4)       13,500      11,003 (7)
 Executive Vice President,      1995   218,795      76,639    67,028 (4)       67,500       9,889 (7)
 Medical and Regulatory         1994   205,056     120,000    36,190 (4)       40,000       9,397 (7)
 Affairs                                                                      
Mark A. Culhane                 1996   205,000      81,000    72,000 (5)       27,000       3,546 (8)
 Vice President, Finance        1995   190,000      67,000    48,000 (5)       67,500       1,848 (8)
 and Administration,            1994   175,000      75,000         *          125,000       1,720 (8)
 Chief Financial Officer                                                       
 and Secretary                                                                 
Former Executive Officer:                                                     
Thomas E. Moore                 1996   300,000           0         0                0       6,796 (9)
 Chairman of the Board of       1995   367,500     206,719         *                0       1,848 (9)
 Directors and Former           1994   350,000      87,500         *          200,000       1,848 (9)
 Chief Executive Officer                                                      
<FN>
- -------------
* No disclosure required under Securities and Exchange Commission rules.

(1)  Mr.  Sellers was  appointed to serve as the  Company's  President  and as a
     director of the Company in January 1996 and its Chief Executive  Officer in
     April 1996.

(2)  Includes amounts deferred under the Company's 401(k) plan.

(3)  Includes $274,427 in 1995 and $252,429 in 1994 in cost-of-living assistance
     payments under an expatriate benefit agreement.

(4)  Includes mortgage  assistance  payments of $92,193 in 1996, $62,800 in 1995
     and $36,190 in 1994 under a housing relocation agreement.

(5)  Consists  of  $60,000  in  1996  and  $36,000  in  1995  in  cost-of-living
     assistance payments.

(6)  Consists of disability and life insurance  premiums ($6,624 in 1996, $7,182
     in 1995, and $3,131 in 1994),  medical  insurance  premiums ($6,340 in 1995
     and  $7,297  in 1994)  and  $1,900  in  matching  contributions  under  the
     Company's 401(k) plan in 1996.

(7)  Consists of term life insurance  premiums  ($3,755 in 1996,  $2,693 in 1995
     and $2,202 in 1994), disability insurance premiums ($5,348 in 1996 and 1995
     and $5,347 in 1994) and matching  contributions  under the Company's 401(k)
     Plan ($1,900 in 1996, $1,848 in 1995 and 1994).

(8)  Consists of matching  contributions under the Company's 401(k) plan ($1,900
     in 1996,  $1,848  in 1995 and  $1,720  in 1994)  and  $1,646  in term  life
     insurance premiums in 1996.

(9)  Consists of $1,900 in matching  contributions  under the  Company's  401(k)
     plan and  $4,896  in term life  insurance  premiums  in 1996 and  $1,848 in
     matching  contributions under the Company's 401(k) plan in each of 1995 and
     1994.
</FN>
</TABLE>

                                       10
<PAGE>
<TABLE>

   The  following  table  provides  certain  information  with  respect to stock
options  granted  to the Named  Executive  Officers  in 1996.  In  addition,  as
required by Securities and Exchange  Commission  rules,  the table set forth the
hypothetical  gains that would exist for the options  based on assumed  rates of
annual compound stock price appreciation during the option term.

                      OPTION/SAR GRANTS IN LAST FISCAL YEAR
<CAPTION>
                               
                                                   INDIVIDUAL GRANTS                    
                               --------------------------------------------------------    POTENTIAL REALIZABLE
                                                                                                   VALUE
                                                                                                AT ASSUMED
                                  NUMBER OF    PERCENT OF TOTAL  EXERCISE                  ANNUAL RATES OF STOCK
                                  SECURITIES     OPTIONS/SARS     OR BASE                   PRICE APPRECIATION
                                  UNDERLYING      GRANTED TO       PRICE                    FOR OPTION TERM(3)
                                 OPTIONS/SARS    EMPLOYEES IN    PER SHARE   EXPIRATION -------------------------
              NAME               GRANTED (#)     FISCAL YEAR      ($/SH)        DATE        5% ($)      10% ($)
- ------------------------------ -------------- ---------------- ----------- ------------ ------------ ------------
<S>                              <C>                <C>          <C>         <C>          <C>          <C>
Donald R. Sellers .............  400,000 (1)        45.9%        $5.375      1/5/2006     $1,354,000   $3,426,000
David L. Horwitz, M.D., Ph.D...   13,500 (2)         1.6%        $ 5.25      1/4/2006     $   44,550   $  112,995
Mark A. Culhane ...............   27,000 (2)        3.10%        $ 5.25      1/4/2006     $   89,100   $  225,990

Former Executive Officer:                          
Thomas E. Moore ...............      -0-            N/A             N/A           N/A            N/A          N/A
<FN>
- ------------------
                                               
(1)  Options  vest  ratably on a monthly  basis over three  years.  The  options
     become fully exercisable without regard to vesting in the event the Company
     is not the  surviving  corporation  in any  merger  or  consolidation.  The
     options have a ten-year  term,  but are subject to earlier  termination  in
     connection with termination of employment.

(2)  Options with respect to 25% of the shares  covered become  exercisable  one
     year from date of grant; thereafter,  options with respect to the remaining
     shares vest ratably on a monthly basis over three years. The options become
     fully exercisable without regard to vesting in the event the Company is not
     the surviving corporation in any merger or consolidation.  The options have
     a ten-year term, but are subject to earlier  termination in connection with
     termination of employment.

(3)  The potential  realizable value portion of the foregoing table  illustrates
     value that might be realized upon exercise of the options immediately prior
     to the expiration of their terms,  assuming the specified  compounded rates
     of appreciation of the market price per share from the date of grant to the
     end of the option term.  Actual gains, if any, on stock option exercise are
     dependent upon a number of factors, including the future performance of the
     Common Stock and the timing of option  exercises,  as well as the optionees
     continued  employment through the vesting period. There can be no assurance
     that the amounts reflected in this table will be achieved.
</FN>
</TABLE>

                                       11
<PAGE>
<TABLE>

   The  following  table sets forth  certain  information  with respect to stock
options exercised by the Named Executive Officers during 1996. In addition,  the
table sets forth the number of shares  covered by stock  options as of  December
31, 1996, and the value of  "in-the-money"  stock options,  which represents the
positive  spread  between the  exercise  price of a stock  option and the market
price of the shares subject to such option on December 31, 1996.

    AGGREGATED OPTION/SAR EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR-END
                                  OPTION VALUES
<CAPTION>
                                          
                                                                 NUMBER OF              VALUE OF   
                                                                UNEXERCISED            UNEXERCISED 
                                                              OPTIONS/SARS AT         IN-THE-MONEY 
                                                              FISCAL YEAR END        OPTIONS/SARS AT
                                    SHARES                          (#)            FISCAL YEAR END ($)
                                   ACQUIRED        VALUE       EXERCISABLE/    EXERCISABLE/UNEXERCISABLE
              NAME              ON EXERCISE (#) REALIZED ($)   UNEXERCISABLE               (1)
- ------------------------------ --------------- ------------ ----------------- ---------------------------
<S>                                   <C>          <C>        <C>                   <C>
Donald R. Sellers .............       -0-          --         225,580/350,420       $430,425/$844,575
David L. Horwitz, M.D., Ph.D...       -0-          --          219,850/92,633       $817,143/$230,398
Mark A. Culhane ...............       -0-          --         154,601/123,732       $454,440/$359,351
Former Executive Officer:                                                           
Thomas E. Moore ...............       -0-          --               200,000/0       $       400,000/0
<FN>
- ------------------
                                               
(1)  Based on the $8.00 per share closing price of the Company's Common Stock on
     the Nasdaq National Market on December 31, 1996, less the exercise prices.
</FN>
</TABLE>

             COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

   Notwithstanding  anything to the contrary set forth in the Company's previous
filings under the Securities Act of 1933 or the Securities  Exchange Act of 1934
that might incorporate future filings,  including this Proxy Statement, in whole
or in part, the following report and the Stock  Performance  Graph which follows
shall not be deemed to be incorporated by reference into any such filings.

   The  Compensation  Committee  of the Board is composed of Messrs.  Cadman and
Goyan,  both of whom are nonemployee  directors.  The Compensation  Committee is
responsible for establishing and administering the Company's  policies regarding
compensation and stock ownership programs.  The Committee annually evaluates the
performance, and determines compensation and long-term equity incentives, of the
Chief Executive Officer ("CEO"), and reviews and approves the CEO's compensation
recommendation  for other  executive  officers  of the  Company,  including  the
Chairman of the Board. 

 Compensation Policy

   The overall  objectives of the Company's  compensation  policy are to attract
and retain  executives of outstanding  ability and potential,  to motivate these
individuals to achieve corporate goals to enhance long-term  shareholder  value,
to link  executive  compensation  and  shareholder  interests,  and to provide a
compensation package that recognizes individual contributions as well as overall
corporate  results and is competitive with leading  biopharmaceutical  companies
with which the Company competes for talent.

   In  the  biopharmaceutical   industry,   traditional  measures  of  corporate
performance,  such as  earnings  per share and  sales  growth,  may not apply in
reviewing the performance of executive officers.  At the Company's current stage
of development,  in evaluating and determining the compensation of the Company's
CEO and other  executive  officers,  the  Compensation  Committee looks to other
performance criteria,  such as progress of the Company's clinical and regulatory
programs and corporate  commercialization and development activities, as well as
the Company's  success in securing capital  resources that are necessary for the
Company to complete  clinical,  regulatory  and  commercialization  programs and
achieve  product  revenues.  As a result,  in many instances  these  qualitative
factors  involve  a  subjective  assessment  of  corporate  performance  by  the
Compensation   Committee.   The   Compensation   Committee  does  not  base  its
considerations on any single performance factor nor does it specifically  assign
relative weights to factors, but rather considers a mix of factors and evaluates
the Company's and individual performance against that mix.

                                       12
<PAGE>

   Compensation for individual  executive  officers is targeted to be comparable
to  compensation  packages paid to other  executives of other  biopharmaceutical
companies  of  comparable  or larger  size with which the Company  competes  for
talent. The Compensation  Committee reviews from time to time independent survey
data regarding  compensation and benefits in the  biopharmaceutical  industry as
well  as   compensation   and  benefits  in  a   comparative   group  of  public
biopharmaceutical companies that represent a number of the Company's most direct
competitors  for executive  talent.  The companies  selected for  comparison are
biopharmaceutical firms with market capitalizations comparable to or larger than
the  Company's,   several  of  which   companies  are  included  in  the  NASDAQ
Pharmaceutical/Biotechnology Index used in the Stock Performance Graph contained
herein.  The  Compensation  Committee  believes that inclusion of companies with
larger market  capitalizations  is necessary  because the talent pool from which
the  Company  recruits  is  composed  largely  of  executives  employed  by such
companies.

   The key elements of the Company's executive  compensation  program consist of
base salary, annual cash incentives and long-term equity incentives. 

 Base Salary

   Base salaries for executive  officers are initially  determined by evaluating
the  responsibilities  of the  position  held  and  the  base  salaries  paid by
biopharmaceutical  companies  generally and companies in the  comparative  group
described above. The Compensation  Committee initially sets base salaries in the
mid to upper  range of base  salaries  at other  companies  in such  comparative
group.  In certain  cases,  minimum base salaries are  established by employment
agreements  between the Company and its executive  officers.  Using this general
guideline,  the Compensation  Committee then considers other factors such as the
individual's  contribution to achievement of corporate  goals, the attainment of
specific individual objectives and the assumption of new responsibilities.  From
year to year, the relative  weighting of the individual  factors may differ from
officer to  officer,  and can be expected to change over time in response to the
Company's development stage and the evolution of the biopharmaceutical industry.

 Annual Cash Incentives

   The Company's annual cash incentives account for a significant  percentage of
each executive  officer's  potential  compensation.  The Compensation  Committee
establishes annual cash incentive targets for executive officers based upon cash
incentive programs of biopharmaceutical companies generally and companies in the
comparative  group described above. The  Compensation  Committee  generally sets
such  targets  in the mid to  upper  range  of  cash  incentives  paid by  other
companies in such  comparative  group.  The actual cash  incentive  award earned
depends upon the attainment of corporate  performance  goals established for the
year by the  Committee  as  well as the  attainment  of  individual  performance
objectives.  Corporate  performance  goals  for 1996  were (i)  registration  of
thymosin  alpha 1 in at least  one  additional  Asian  country  and at least one
Middle  Eastern  country,  (ii)  submission  of  thymosin  alpha 1  registration
applications  in at least  eight  additional  countries,  (iii)  conclusions  of
thymosin  alpha 1 trial in  Taiwan,  and (iv)  creation  and  implementation  of
thymosin  alpha 1 and CPX  development  plans.  At year  end,  the  Compensation
Committee reviewed the original plans and goals. The Committee  determined that,
due to the significant  efforts and  accomplishments of the Company's  executive
officers, many of the original goals had been achieved;  however,  certain goals
deemed  significant  by the  Committee  were  not  achieved.  As a  result,  the
executive  officers  received less than their targeted annual cash incentive and
received  cash  incentives  ranging  from 35% to 40% of base  salary.  

 Long-Term Equity Incentives

   The Company's long-term equity incentives  currently consist of the Company's
1991  and  1992  Stock  Plans  and the  Company's  1995  Equity  Incentive  Plan
(collectively,  the "Plans"),  pursuant to which the Company  grants options and
other rights to purchase  shares of its Common  Stock.  The objective of each of
the  Plans  is to  advance  the  long-term  interests  of the  Company  and  its
shareholders  and to complement  incentives  tied to annual  performance.  Stock
options  granted  under  the  Plans  generally  vest  over a four  year  period,
providing  incentive to create  value for the  Company's  shareholders  over the
long-term since the full benefit of the compensation  package cannot be realized
unless the employee remains with the Company and stock price appreciation occurs
over a number of years. The Compensation Committee has typically granted options
to employees upon commencement of employment and has occasionally granted

                                       13
<PAGE>

additional options following a significant change in job  responsibility,  scope
or title or a  particularly  noteworthy  corporate  or  individual  achievement.
During 1996, certain executive officers and employees were granted stock options
based on their individual  contribution to achievement of corporate  performance
goals.  In  January  1996,  the  Compensation  Committee  granted  option to Mr.
Sellers, in connection with his assuming the role of Chief Executive Officer, to
acquire 400,000 shares of Common Stock at a price per share of $5.375,  the fair
market value on the date of grant.  The shares vest monthly over 36 months.  

 CEO Compensation

   In 1996,  Mr.  Sellers  received a base salary of $400,000 and an annual cash
incentive  payment of $150,000.  In determining  Mr.  Sellers' base salary,  the
Compensation  Committee  considered  Mr.  Seller's  current  compensation,   his
expected role with the Company and data with respect to  compensation  levels at
other biotechnology Companies,  along with certain tax effects of his relocation
to the United States. With respect to Mr. Sellers' cash incentive, the Committee
noted that the  corporate  performance  objectives  for the Company were met and
that, with one exception Mr.  Sellers'  individual  performance  objectives were
achieved;  however,  the Company had not achieved  the targeted  increase in its
stock  price  which was a  significant  performance  objective.  Therefore,  the
Compensation  Committee  awarded  Mr.  Sellers  an  actual  bonus  less than his
targeted incentive resulting in a bonus equal to 37.5% of his base salary.

   In 1996,  Mr.  Moore  received a base salary of  $300,000  and no annual cash
incentive  payment.  In reducing Mr. Moore's base salary and cash incentive from
fiscal 1995, the Compensation  Committee noted that the reduction was reflective
of Mr. Moore's changing role in the Company. 

 Special Deduction Limit

   The Compensation Committee has considered the impact of Section 162(m) of the
Code adopted under the Omnibus Budget  Reconciliation Act of 1993, which section
disallows  a  deduction  for  any   publicly-held   corporation  for  individual
compensation  exceeding  $1.0  million in any taxable  year for the CEO and four
other most highly compensated executive officers, unless such compensation meets
the  requirements  for the  "performance-based"  exception to the general  rule.
Since  the  cash  compensation  paid by the  Company  to  each of its  executive
officers is expected to be well below $1.0 million,  and the Committee  believes
that options granted under the 1995 Equity Incentive Plan prior to the Company's
Annual  Meeting  in  1996  will  meet  the  requirements  for  performance-based
compensation under Section 162(m), the Compensation Committee believes that this
section will not affect the tax deductions available to the Company with respect
to  such  options.   However,  because  a  transition  rule  which  permits  the
Compensation   Committee   to   qualify   as  a   committee   which   may  award
performance-based compensation expired upon the Company's Annual Meeting in 1996
and the  Compensation  Committee may not so qualify,  the Company can provide no
assurance that options  granted under the 1995 Equity  Incentive Plan after that
date will meet the requirements for performance-based compensation.

   The foregoing report has been provided by Messrs. Cadman and Goyan.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

   During the year ended December 31, 1996,  Messrs.  Cadman and Goyan served on
the Compensation Committee of the Board.

                                       14
<PAGE>

                             STOCK PERFORMANCE GRAPH

   The  following  graph  compares  the  annual  percentage  change  in (i)  the
cumulative  total  shareholder  return on the Company's Common Stock since March
17, 1992, the effective date of the Company's initial public offering, with (ii)
the  cumulative  total return on (a) The Nasdaq  Stock Market (U.S.  and Foreign
Companies) and (b) the NASDAQ Pharmaceutical/Biotechnology Index. The comparison
assumes (i) an  investment  of $100 on March 17,  1992 in each of the  foregoing
indices and (ii) reinvestment of dividends,  if any. The stock price performance
shown on the graph below is not  necessarily  indicative  of future  stock price
performance.S

[The following  descriptive  data is supplied in accordance  with Rule 304(d) of
Regulation S-T]

                                         COMPUTER INDEX
                      -----------------------------------------------------
                       SciClone              NASDAQ               NASDAQ
Performance             Common              Stock Mkt.          Parm. Com.
  Period                 Stock              US & Frgn            SIC 283
  ------                 -----              ---------            -------
03/17/92                100.000              100.000             100.000
12/31/92                197.143              108.894             092.495
12/31/93                262.857              123.713             083.673
12/30/94                077.143              119.674             062.372
12/29/95                058.571              170.014             113.660
12/31/96                091.429              211.232             113.947



                                       15
<PAGE>

                          TRANSACTIONS WITH MANAGEMENT

   The Company has entered into an employment agreement with Dr. Horwitz.  Under
the  agreement,  Dr.  Horwitz  receives an annual  salary and is eligible for an
annual cash  incentive and other  benefits  that are  generally  provided to the
Company's  executives.  In the  event  the  Company  terminates  its  employment
relationship with Dr. Horwitz without cause, or if Dr. Horwitz's relationship or
responsibilities  change  without his  consent,  the Company will be required to
continue  to pay Dr.  Horwitz's  normal  salary  and  benefits  for six  months.
Pursuant to the  agreement,  the Company  also  granted Dr.  Horwitz  options to
purchase  shares of the Company's  Common Stock and  reimbursed  Dr. Horwitz for
certain  moving costs and agreed to make certain  cash  payments to Dr.  Horwitz
upon  exercise  of options  granted  pursuant to the  agreement  and to defray a
portion of his housing expenses.

   The Company has entered into an employment agreement with Mr. Culhane.  Under
the  agreement,  Mr.  Culhane  receives an annual  salary and is eligible for an
annual cash  incentive and other  benefits  that are  generally  provided to the
Company's  executives.  In the  event  the  Company  terminates  its  employment
relationship  with Mr. Culhane  without cause,  the Company will continue to pay
Mr.  Culhane's  annual  salary  and  benefits  for twelve  months,  pay any cash
incentives as if Mr. Culhane had continued his employment through the end of the
calendar year,  accelerate the vesting of all of Mr. Culhane's outstanding stock
options so they become fully  vested,  and extend the  exercise  period for such
options for one year,  but within the original  term of the option.  The Company
has also agreed to make certain cash  payments to Mr.  Culhane upon  exercise of
stock options granted to Mr. Culhane prior to 1994.

   The Company has entered into an employment agreement with Mr. Sellers.  Under
the  agreement,  Mr.  Sellers  receives an annual  salary and is eligible for an
annual cash  incentive and other  benefits  that are  generally  provided to the
Company's  executives.  In the  event  the  Company  terminates  its  employment
relationship  with Mr. Sellers without cause, the Company will pay Mr. Sellers a
severance  payment equal to his annual salary and benefits for twelve months and
any cash  incentives as if Mr. Sellers has continued his employment  through the
end of  the  calendar  year,  accelerate  the  vesting  of  all of Mr.  Sellers'
outstanding  stock options so they become fully vested,  and extend the exercise
period  for such  options  for one year,  but within  the  original  term of the
option.

   In June 1995,  the  Company  extended  a loan to Dr.  David  Horwitz  with an
aggregate  principal amount of $1,365,000 to be used to finance the purchase and
renovation of Dr. Horwitz's primary  residence.  The loan was secured by a first
deed of trust on the property and 20,000  shares of SciClone  Common stock owned
by Dr.  Horwitz,  bears interest at 7.5% per annum and is payable in five years,
subject to renewal if Dr. Horwitz remains  employed by the Company.  Pursuant to
Dr.  Horwitz's  employment  agreement,  the Company will defray a portion of Dr.
Horwitz's monthly mortgage expenses over a five-year period.

   In July  1995,  the  Company  extended a loan to Mr.  Moore in the  principal
amount of $95,000 which carries an interest  rate of 7.375%.  In December  1995,
the Company  extended an additional loan to Mr. Moore in the principal amount of
$600,000 which carries an interest rate of 7.50%.  The loans are due and payable
in  December  1997,  are  currently  unsecured  and are in the  process of being
secured by a second deed of trust on residential property owned by Mr.
Moore.

   In August 1996,  the Company  extended a loan to Mr. Sellers in the principal
amount of  $1,000,000  which was used to finance  the  purchase  of his  primary
residence.  The loan was secured by a first deed of trust on the property, bears
interest at 8.0% per annum and is payable in five  years,  subject to renewal if
Mr. Sellers remains employed by the Company.

                              SHAREHOLDER PROPOSALS

   Proposals of  shareholders  intended to be presented  at the  Company's  1997
Annual  Meeting of  Shareholders  must be received by Mark A. Culhane,  SciClone
Pharmaceuticals,  Inc., 901 Mariners  Island  Boulevard,  San Mateo,  California
94404, no later than January 8, 1998.

                                       16
<PAGE>

              COMPLIANCE WITH SECTION 16(A) OF THE EXCHANGE ACT

   Section 16(a) of the Exchange Act requires the Company's directors, executive
officers  and  persons  who own more  than  10% of the  Company's  Common  Stock
(collectively,  "Reporting  Persons") to file with the  Securities  and Exchange
Commission  ("SEC") initial reports of ownership and changes in ownership of the
Company's  Common Stock.  Reporting  Persons are required by SEC  regulations to
furnish the Company with copies of all Section 16(a) reports they file.

   To the Company's knowledge,  based solely on its review of the copies of such
reports received or written  representations from certain Reporting Persons that
no other reports were required, the Company believes that during its fiscal year
ended  December 31, 1996,  all Reporting  Persons  complied with all  applicable
filing  requirements,  except  that  one  statement  of  changes  in  beneficial
ownership  for David L.  Horowitz,  M.D.,  Ph.D.,  an  officer  of the  Company,
reporting one transaction, was not timely filed.

                                OTHER MATTERS

   The Board of Directors  knows of no other business which will be presented to
the Annual Meeting.  If any other business is properly brought before the Annual
Meeting,  proxies in the enclosed  form will be voted in respect  thereof as the
proxy holders deem advisable.

   It is important that the proxies be returned promptly and that your shares be
represented.  Shareholders are urged to mark, date,  execute and promptly return
the accompanying proxy card in the enclosed envelope.


                                  By Order of the Board of Directors,

                                  /s/ Mark A. Culhane

                                  MARK A. CULHANE
                                  Secretary


April 18, 1997
San Mateo, California

                                       17
<PAGE>

                                                                      APPENDIX A

- --------------------------------------------------------------------------------
PROXY                     SCICLONE PHARMACEUTICALS, INC.                   PROXY
                    PROXY FOR ANNUAL MEETING OF SHAREHOLDERS
                         SOLICITED BY BOARD OF DIRECTORS

   The undersigned  hereby  appoints Donald R. Sellers and Mark A. Culhane,  and
each of them,  with full power of  substitution to represent the undersigned and
to vote all the  shares  of the stock of  SciClone  Pharmaceuticals,  Inc.  (the
"Company")  which the  undersigned  is entitled to vote at the Annual Meeting of
Shareholders  of the Company to be held at the Hotel  Sofitel,  233 Twin Dolphin
Drive,  Redwood City,  California  94065, on Friday,  May 16, 1997, at 9:00 a.m.
local time, and at any adjournment thereof (1) as hereinafter specified upon the
proposals listed below and as more particularly described in the Company's Proxy
Statement, receipt of which is hereby acknowledged,  and (2) in their discretion
upon such other matters as may properly come before the meeting. The undersigned
hereby acknowledges receipt of the Company's 1996 Annual Report to Shareholders.

   WHETHER  OR NOT YOU PLAN TO ATTEND THE  MEETING  IN PERSON,  YOU ARE URGED TO
SIGN AND PROMPTLY MAIL THIS PROXY IN THE RETURN  ENVELOPE SO THAT YOUR STOCK MAY
BE REPRESENTED AT THE MEETING.

   THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS OF THE COMPANY.

   THE  SHARES   REPRESENTED   HEREBY  SHALL  BE  VOTED  AS  SPECIFIED.   IF  NO
SPECIFICATION  IS MADE,  SUCH  SHARES  SHALL BE  VOTED IN FAVOR OF  PROPOSALS  1
THROUGH 3.

                (Continued, and to be signed on the other side)
- --------------------------------------------------------------------------------
<PAGE>
<TABLE>

- -----------------------------------------------------------------------------------------------------------------------------------
<CAPTION>
<S>                                                         <C>   

                                                                                                                    [X] Please mark
                                                                                                                         your votes
                                                                                                                           as this

1. Election of Directors                WITHHOLD                                                            FOR   AGAINST  ABSTAIN 
   (INSTRUCTION: TO WITHHOLD      FOR    FOR ALL           2. To approve an amendment  to the  Company's    [  ]    [  ]     [  ]  
   AUTHORITY TO VOTE FOR ANY      [  ]    [  ]                1995 Equity  Incentive Plan to increase by                           
   INDIVIDUAL NOMINEE, STRIKE                                 750,000  the  maximum  number of shares of                           
   A LINE THROUGH THAT NOMINEE'S                              Common Stock that may be issued under such                           
   NAME IN THE LIST BELOW.)                                   plan.                                                                
                                                                                                                                   
Donald R. Sellers, Thomas E. Moore, John D. Baxter, M.D.   3. To ratify the appointment of Ernst & Young    [  ]    [  ]     [  ]  
Edwin C. Cadman, M.D., Jere E. Goyan, Ph.D.                   LLP as the  independent  auditors  for the                           
                                                              Company for the year ending  December  31,                           
_________________________________________________________     1997.                                                                
                                                                                                                                   
I PLAN TO ATTEND THE MEETING               [  ]               A VOTE  FOR  THE  PRECEDING  PROPOSALS  IS                           
                                                              RECOMMENDED BY THE BOARD OF DIRECTORS.                               
                                                                                                                                   
                                                           

Signature(s)___________________________________________________________________             Dated __________________________, 1997

Sign  exactly as your  name(s)  appears on your stock  certificate.  If shares of stock  stand of record in the names of two or more
persons or in the name of husband and wife, whether as joint tenants or otherwise,  both or all of such should sign the above Proxy.
If shares of stock are held of record by a  corporation,  the Proxy should be executed by the  President or Vice  President  and the
Secretary or Assistant Secretary, and the corporate seal should be affixed thereto. Executors or administrators or other fiduciaries
who execute the above Proxy for a decreased shareholder should give their full title. Please date the Proxy.

- -----------------------------------------------------------------------------------------------------------------------------------
</TABLE>



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