SCICLONE PHARMACEUTICALS INC
S-3/A, 1997-12-02
PHARMACEUTICAL PREPARATIONS
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        As Filed With the Securities and Exchange Commission on December 2, 1997
                                                      Registration No. 333-38773
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                             ----------------------

                                Amendment No. 3
                                       to
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933

                             ----------------------

                         SCICLONE PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)

         California                                            94-3116852
(State or other jurisdiction of                              (IRS Employer
 incorporation or organization)                           Identification No.)

                             ----------------------

                          901 Mariners Island Boulevard
                           San Mateo, California 94404
                                 (650) 358-3456
    (Address, including zip code, and telephone number, including area code,
                  of registrant's principal executive offices)

                             ----------------------

                                Donald R. Sellers
                      President and Chief Executive Officer
                         SciClone Pharmaceuticals, Inc.
                          901 Mariners Island Boulevard
                           San Mateo, California 94404
                                 (650) 358-3456
 (Name, address, including zip code, and telephone number, including area code,
                              of agent for service)

                             ----------------------

                                   Copies to:
    J. HOWARD CLOWES, ESQ.                           JAMES R. TANENBAUM, ESQ.
   DIANNE B. SALESIN, ESQ.                         Stroock & Stroock & Lavan LLP
      JOHN M. FOGG, ESQ.                                 180 Maiden Lane
 Gray Cary Ware & Freidenrich                        New York, New York 10038
  A Professional Corporation
     400 Hamilton Avenue
 Palo Alto, California 94301

                             ----------------------

         Approximate  date of  commencement  of proposed sale to the public:  As
soon as practicable after this Registration Statement becomes effective.

      If the only  securities  being  registered  on this Form are being offered
pursuant to dividend or interest  reinvestment plans, please check the following
box: [ ]
      If any of the securities  being  registered on this Form are to be offered
on a delayed or continuous  basis  pursuant to Rule 415 under the Securities Act
of 1933,  other than  securities  offered only in  connection  with  dividend or
interest reinvestment plans, check the following box: [ ]
      If this Form is filed to register  additional  securities  for an offering
pursuant to Rule 462(b) under the  Securities  Act,  check the following box and
list the Securities Act registration  statement number of the earlier  effective
registration statement for the same offering. [ ]
      If this Form is a  post-effective  amendment filed pursuant to Rule 462(c)
under the  Securities  Act,  check the following box and list the Securities Act
registration  statement number of the earlier effective  registration  statement
for the same offering: [ ]
      If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box: [ ]

      The Registrant hereby amends this  Registration  Statement on such date or
dates as may be necessary to delay its effective date until the Registrant shall
file a further  amendment  which  specifically  states  that  this  Registration
Statement shall  thereafter  become effective in accordance with Section 8(a) of
the  Securities  Act of 1933 or until the  Registration  Statement  shall become
effective on such date as the Commission  acting  pursuant to said Section 8(a),
may determine.

================================================================================
<PAGE>

                                EXPLANATORY NOTE

      Amendment No. 3 is being filed solely for the purpose of filing an exhibit
to the Registration Statement.




<PAGE>

                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.      Other Expenses of Issuance and Distribution

      The following table sets forth the various expenses in connection with the
sale  and  distribution  of the  securities  being  registered,  other  than the
Placement Agent's fee. All amounts shown are estimates except the Securities and
Exchange  Commission  registration  fee,  the  NASD  filing  fee and the  Nasdaq
National Market listing fee.

Item                                                                Amount
- ----                                                                ------
Securities and Exchange Commission registration fee.........     $       2,814
NASD filing fee.............................................             1,429
Nasdaq National Market listing fee..........................            17,500
Blue sky qualification fees and expenses....................             3,000
Accounting fees and expenses................................            20,000
Legal fees and expenses.....................................           160,000
Printing and engraving expenses.............................            10,000
Transfer agent and registrar fees...........................             2,000
Miscellaneous expenses......................................             8,257
                                                                --------------
         Total..............................................    $      225,000
                                                                ==============


Item 15.      Indemnification of Directors and Officers

      The Company's Restated Articles of Incorporation, as amended, provide that
the liability of the  directors for monetary  damages shall be eliminated to the
fullest extent permissible under California law. Pursuant to California law, the
Company's  directors shall not be liable for monetary  damages for breach of the
directors' fiduciary duty of care to the Company and its shareholders.  However,
this provision in the Restated Articles of Incorporation  does not eliminate the
duty of  care,  and in  appropriate  circumstances  equitable  remedies  such as
injunctive  or other forms of  nonmonetary  relief will remain  available  under
California  law.  In  addition,  each  director  will  continue to be subject to
liability  (i) for acts or omissions  that involve  intentional  misconduct or a
knowing  and  culpable  violation  of law,  (ii)  for acts or  omissions  that a
director  believes to be contrary  to the best  interests  of the Company or its
shareholders  or that  involve  the  absence  of good  faith  on the part of the
director,  (iii) for any transaction  from which a director  derived an improper
personal benefit,  (iv) for acts or omissions that show a reckless disregard for
the director's duty to the Company or its shareholders in circumstances in which
the director  was aware,  or should have been aware,  in the ordinary  course of
performing a director's  duties,  of a risk of serious  injury to the Company or
its shareholders, (v) for acts or omissions that constitute an unexcused pattern
of  inattention  that amounts to an  abdication  of the  director's  duty to the
Company  or its  shareholders,  (vi) for any  transaction  that  constitutes  an
illegal  distribution  or  dividend  under  California  law,  and  (vii) for any
transaction  involving an unlawful conflict of interest between the director and
the  Company  under  California  law.  The  provision  also  does  not  affect a
director's  responsibilities under any other law, such as the federal securities
laws or state or federal environmental laws.

      In addition, the Company's Restated Articles of Incorporation, as amended,
provide that the Company is authorized to provide  indemnification of agents (as
defined  under  California  law)  for  breach  of  duty to the  Company  and its
shareholders  through  bylaw  provisions,  agreements  with the agents,  vote of
shareholders  or  disinterested   directors  or  otherwise,  in  excess  of  the
indemnification  otherwise permitted by California law, subject to the limits on
such excess indemnification set forth in California law.

      The Company's Bylaws provide that the Company will indemnify its directors
and officers to the maximum extent and in the manner permitted by California law
and may indemnify  its  employees and other agents to the maximum  extent and in
the manner  permitted by  California  law. Such  indemnification  is intended to
provide the 

                                      II-1
<PAGE>

full  flexibility   available  under  California  law  and  may,  under  certain
circumstances,  include  indemnification  for negligence,  gross  negligence and
certain types of recklessness.  Under  California law and the Company's  Bylaws,
the Company will be permitted to indemnify its  directors,  officers,  employees
and other  agents,  within the  limits  established  by law and  public  policy,
pursuant to an express contract, bylaw provision, shareholder vote or otherwise,
any or all of which could  provide  indemnification  rights  broader  than those
expressly   available  under  California  law.  The  Company  has  entered  into
agreements with its directors and certain of its officers,  including all of its
executive  officers,  that require the Company to indemnify such persons against
expenses,   judgments,   fines,  settlements  and  other  amounts  actually  and
reasonably  incurred  (including  expenses of a derivative action) in connection
with any proceeding,  whether actual or threatened, to which any such person may
be made a party by reason of the fact that such  person is or was a director  or
an officer of the Company or any of its  affiliated  enterprises,  provided such
person acted in good faith and in a manner such person reasonably believed to be
in or not opposed to the best  interests of the Company and, with respect to any
criminal  proceeding,  had no reasonable cause to believe his or her conduct was
unlawful. The indemnification  agreements also set forth certain procedures that
will apply in the event of a claim for indemnification thereunder.

      The form of  Placement  Agent  Agreement  filed as Exhibit 1.1 hereto sets
forth  certain  provisions  with  respect  to  the  indemnification  of  certain
controlling   persons,   directors  and  officers  against  certain  losses  and
liabilities, including certain liabilities under the Securities Act.

Item 16.      Exhibits

      See Exhibit Index.

Item 17.      Undertakings

      Insofar as  indemnification  for liabilities  arising under the Securities
Act of 1933 may be permitted to directors,  officers and controlling  persons of
the  Registrant,  pursuant  to  the  foregoing  provisions,  or  otherwise,  the
Registrant  has been advised that in the opinion of the  Securities and Exchange
Commission  such  indemnification  is against  public policy as expressed in the
Securities Act and is, therefore,  unenforceable.  In the event that a claim for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
Registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  Registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against  public policy as expressed in the  Securities
Act and will be governed by the final adjudication of such issue.

      The undersigned Registrant undertakes that:

      (1) For purposes of determining  any liability under the Securities act of
1933, the information  omitted from the form of prospectus filed as part of this
registration  statement in reliance  upon Rule 4340A and  contained in a form of
prospectus  filed by the Registrant  pursuant to Rule 424(b)(1) of (4) or 497(h)
under  the  Securities  Act  shall  be  deemed  to be part of this  registration
statement as of the time it was declared effective; and

      (2) For the purpose of determining any liability under the Securities Act,
each post-effective amendment that contains a form of prospectus shall be deemed
to be a new registration  statement  relating to the securities offered therein,
and the  offering  of such  securities  at that  time  shall be deemed to be the
initial bona fide offering thereof.

      The  undersigned  Registrant  hereby  undertakes  that,  for  purposes  of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
Registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange  Act of  1934  that is  incorporated  by  reference  in the
registration  statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.


                                      II-2
<PAGE>

                                   SIGNATURES

      Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for filing on Form S-3 and has duly caused this Amendment No. 3 to
Registration Statement to be signed on its behalf by the undersigned,  thereunto
duly authorized,  in the City of San Mateo, State of California,  on the 2nd day
of December , 1997.

                                      SCICLONE PHARMACEUTICALS, INC.


                                      By:  /s/ MARK A. CULHANE
                                           -------------------------------------
                                           Mark A. Culhane
                                           Chief Financial Officer
                                           (Principal Financial and
                                           Acccounting Officer)


<TABLE>

      Pursuant to the requirements of the Securities Act of 1933, this Amendment
No.3 to Registration  Statement has been signed by the following  persons in the
capacities and on the dates indicated.
<CAPTION>

Signature                                                 Title                                          Date
- ---------                                                 -----                                          ----


<S>                                       <C>                                                     <C> 
     DONALD R. SELLERS*                   President, Chief Executive Officer,                     December 2, 1997
- ------------------------------------      and Director (Principal Executive Officer)
    Donald R. Sellers                     


 /s/ MARK A. CULHANE                      Vice President, Finance and                             December 2, 1997
- ------------------------------------      Administration, Chief Financial Officer      
    Mark A. Culhane                       and Secretary                                
                                          (Principal Financial and Accounting Officer) 
                                          

     JERE E. GOYAN*                       Chairman of the Board and Director                      December 2, 1997
- ------------------------------------
     Jere E. Goyan, Ph.D


     JOHN D. BAXTER*                      Director                                                December 2, 1997
- ------------------------------------
     John D. Baxter, M.D.


     EDWIN C. CADMAN*                     Director                                                December 2, 1997
- ------------------------------------
     Edwin C. Cadman, M.D.


     ROLF H. HENEL*                        Director                                               December 2, 1997
- ------------------------------------
     Rolf H. Henel


*By /s/ MARK A. CULHANE                                                                           December 2, 1997
- ------------------------------------
    Mark A. Culhane, Attorney-in-Fact                                
                                           
</TABLE>


<PAGE>
                                  EXHIBIT INDEX


Exhibit Number
                 Description of Document


      1.1*       Form of Placement Agency Agreement  between EVEREN  Securities,
                 Inc. and the Company.

      4.1*       Rights Agreement,  dated as of July 25, 1997,  between SciClone
                 and ChaseMellon  Shareholder  Services,  LLC.  (incorporated by
                 reference to the Company's  Current Report on Form 8-K filed on
                 October 14, 1997).

      5.1*       Opinion of Gray Cary Ware & Freidenrich.

     10.1        Purchase and Sale, Pledge and Security Agreement; Release dated
                 as of July 23,  1997 by  Thomas  Moore,  in  favor of  SciClone
                 Pharmaceuticals, Inc.

     10.2*       Form of Escrow Agreement among the Company, the Placement Agent
                 and the Escrow Agent (included in Exhibit 1.1)

     23.1*       Consent of Gray Cary Ware &  Freidenrich  (included  in Exhibit
                 5.1).

     23.2*       Consent of Ernst & Young LLP.

     24.1*       Power of Attorney.


- -----------------------
*   Previously filed.

                                      II-4


                                                                    EXHIBIT 10.1


                               PURCHASE AND SALE,

                     PLEDGE AND SECURITY AGREEMENT; RELEASE

     THIS PURCHASE AND SALE PLEDGE AND SECURITY  AGREEMENT (this "Agreement") is
made as of July 23, 1997, by Thomas Moore, an individual  ("Pledgor"),  in favor
of SciClone Pharmaceuticals, Inc., a California corporation ("Pledgee").


                                    RECITALS

     WHEREAS,  Pledgor  has  borrowed  from  Pledgee,  and Pledgee has loaned to
Pledgor,  the  principal  sum of Two  Million  Eight  Hundred  Thousand  Dollars
($2,800,000)  pursuant to that certain  $2,800,000  Promissory  Note dated as of
July 10, 1997, made by Pledgor in favor of Pledgee (the "Unsecured Note");

     WHEREAS, various disputes have arisen between the parties which the parties
wish to resolve and to terminate  any prior  agreements  relating to the subject
matter hereof;

     WHEREAS,  Pledgor has agreed to borrow from Pledgee, and Pledgee has agreed
to loan to Pledgor,  up to an additional  Three  Million One Hundred  Forty-Four
Thousand Dollars  ($3,144,000) (the "Additional Loan Amount"),  to be aggregated
with the existing indebtedness (including accrued and unpaid interest) under the
Unsecured  Note (which  shall be  superseded  and  canceled  upon the  execution
hereof) and evidenced by that certain  $5,944,000  Secured Promissory Note dated
of even date  herewith  and made by Pledgor in favor of  Pledgee  (the  "Secured
Note");

     WHEREAS,  Pledgee, as a condition to issuing the Secured Note, is requiring
Pledgor to pledge, as security for Pledgor's obligations under the Secured Note,
One Million Eight Hundred Eighty-Two Thousand Five Hundred (1,882,500) shares of
common stock of Pledgee (the "Pledged Shares");

     WHEREAS, Pledgor is willing to so pledge the Pledged Shares, and Pledgee is
willing to issue the Secured Note, all according to the terms and subject to the
conditions of this Agreement and the Secured Note.

     WHEREAS,  the parties  intend by  execution  hereof to resolve a variety of
issues and claims including, in addition to securing the Secured Note, providing
for the purchase and sale of stock on reasonable  terms,  and the  consideration
provided  herein  has been  highly  negotiated  by the  parties  to ensure  that
appropriate  benefit is  accorded  for the stock  purchase  and  mutual  release
covenants.


                                    AGREEMENT

     NOW,  THEREFORE,  in consideration  of the mutual  promises,  covenants and
conditions hereinafter set forth and for other good and valuable  consideration,
the  receipt  and  sufficiency  of which are hereby  acknowledged,  Pledgor  and
Pledgee hereby agree as follows:

                                       1

<PAGE>


     1. Pledge of Collateral; Payment of Loan Amounts.

         (a) Pledgor hereby pledges,  assigns and delivers to Pledgee and grants
to Pledgee a security  interest in the Pledged  Shares,  together with any stock
rights,  rights  to  subscribe,  dividends  paid in cash or  other  property  in
connection with the complete or partial liquidation of Pledgee, stock dividends,
dividends paid in stock,  new securities or other property except cash dividends
other than liquidating dividends to which the Pledgor is or may hereafter become
entitled  to receive  on account of  Pledgor's  ownership  of such  shares  (the
"Pledged  Collateral")  as security for the prompt  performance of all Pledgor's
obligations under the Secured Note.

         (b) Pledgee hereby agrees as follows:

               i. Upon the execution  and delivery of this  Agreement by Pledgee
and Pledgor,  the  execution and delivery by Pledgor of the Secured Note and the
execution and delivery by the Pledgor and, where applicable, the Pledgee, of the
letters of instruction attached hereto as Annex A, it will cancel and deliver to
the Pledgor the Unsecured Promissory Note;

               ii. Upon receipt of letters of confirmation from Smith Barney and
Goldman Sachs of receipt of letters of  instruction  sent to them by the Pledgor
instructing  them to deliver  certain of the Shares held by them for the account
of Pledgor to Pledgee upon receipt of funds from Pledgee, Pledgee will pay up to
Five Hundred  Sixty-Five  Thousand  Dollars  ($565,000) of the  Additional  Loan
Amount to Smith Barney and will pay up to Two Hundred  Ninety  Thousand  Dollars
($290,000)  of the  Additional  Loan Amount shall be paid to Goldman  Sachs,  as
necessary  to  pay  the  total  outstanding  loan  balance  in  margin  accounts
maintained at Smith Barney and Goldman Sachs on behalf of the Pledgor;

               iii.   Upon   receipt   from  Pledgor  or  his  agents  of  stock
certificates evidencing the Pledged Shares (other than those Pledged Shares held
by Smith Barney and Goldman  Sachs),  and five (5)  executed  but undated  stock
assignments separate from certificate  substantially in the form attached hereto
as Exhibit 1, the Pledgee will pay the remainder of the Additional  Loan Payment
as follows:

                       a)  One  Hundred  Sixty   Thousand   Dollars   ($160,000)
representing satisfaction of outstanding indebtedness owed to the Pledgor by the
Pledgee shall be retained by the Pledgee;]

                       b) The remainder of the Additional  Loan Payment shall be
paid to the Pledgor

         (c) In the event that Pledgor receives any of the property described in
paragraph (a) of this Section 1 on account of Pledgor's ownership of the Pledged
Collateral after the date hereof, Pledgor will immediately deliver such property
to Pledgee in the manner set forth in paragraph (b) of this Section 1.

     2.  Representations,  Warranties  and  Covenants.  Pledgor  represents  and
warrants to, and covenants with, Pledgee during the term hereof that:

                                       2

<PAGE>


         (a) The Pledged  Collateral  is owned by Pledgor  free and clear of any
security  interests,  liens,  encumbrances,  options or other restrictions other
than those set forth in this Agreement and the Secured Note;

         (b)  Pledgor  has full  power  and  authority  to  create a lien on the
Pledged  Collateral  in  favor  of  Pledgee  and no  disability  or  contractual
obligation  exists  that  would  prohibit  Pledgor  from  pledging  the  Pledged
Collateral  pursuant to this Agreement,  and Pledgor will not assign,  create or
permit to exist any  other  claim to,  lien or  encumbrance  upon,  or  security
interest in any of the Pledged Collateral;

         (c) Pledgor  shall,  immediately  upon Pledgee's  request,  execute and
deliver such further instruments and documents, and take all such other actions,
as Pledgee  deems  reasonably  necessary or  desirable  to further  evidence and
perfect this pledge and grant of security; and

         (d)  The  Pledged  Collateral  is not the  subject  of any  present  or
threatened suit, action,  arbitration,  administrative or other proceeding,  and
Pledgor  knows  of no  reasonable  grounds  for  the  institution  of  any  such
proceedings.

     All the above representations and warranties shall survive the date of this
Agreement.

     3.  Conditions to Obligations of Pledgee.  The obligation of the Pledgee to
consummate the transactions contemplated herein is subject to the fulfillment of
the  following  condition:  the Board of  Directors  of the  Pledgee  shall have
approved the consummation of the Transactions.

     4. Covenants of Pledgor.  Pledgor hereby  covenants and agrees that he will
not enter into any additional margin,  hedging or similar transaction  including
shares of Common  Stock of the Pledgee for a period of ninety (90) days from the
date hereof, other than the pledging of securities,  if required,  as additional
collateral  for  principal  outstanding  on the date  hereof owed to Wells Fargo
Bank.

     5. Covenants of Pledgee.  Pledgee hereby  covenants and agrees that it will
review  written  records  submitted  by the Pledgor of expenses  incurred by the
Pledgor  on  behalf  of the  Pledgee  and  that it will do so in an  expeditious
fashion and will repay all  resonable  and bona fide expenses as the Pledgor can
reasonably documents based upon such records as the Pledgor submits.

     6. Right of Repurchase;  Full or Partial  Cancellation of Secured Note Upon
Repurchase.

                                       3

<PAGE>


         (a) At any time after the date of this Agreement,  immediately prior to
the  consummation  of any  offering  by Pledgee  of shares of its  Common  Stock
(whether  in a  registered  public  offering  or  in a  private  placement)  (an
"Offering"), the Pledgee shall have the right to repurchase up to that number of
Pledged  Shares  (but in no event  more than the  number of  Pledged  Shares) as
determined by a fraction, the numerator of which shall be equal to the amount of
principal  and accrued and unpaid  interest due under the Secured Note as of the
date of repurchase,  and the denominator of which (the "Share Repurchase Price")
shall be calculated pursuant to the following formula:

                               S = Z - .5D - .15Z

Where:

         S    =   the Share Repurchase Price;

         Z    =   the price per share at which  Common  Stock of the  Pledgee is
                  sold in the Offering;

         D    =   the greater of (i) zero, or (ii) Z - $12.

         (b) Upon Pledgee's exercise of its right of repurchase under subsection
(a) hereof,  and without any further  action on the part of the parties  hereto,
there shall be a cancellation of all or a portion of the amount of principal and
accrued and unpaid  interest due under the Secured  Note,  in an amount equal to
the number of shares of Pledged Stock  repurchased  pursuant to  subsection  (a)
hereof (the "Repurchased  Shares) multiplied by the Share Repurchase Price. Such
amounts shall be applied first to accrued and unpaid  interest under the Secured
Note and then to  principal.  further,  Pledgee  shall be  entitled  to cancel a
number of shares equal to the prorata  portion of the expenses  associated  with
the offering allocable to the Repurchased Shares divided by the Share Repurchase
Price.

         (c) Pledgee may determine in its discretion the timing of and amount of
any Offering.

         (d) If Pledgor  repays the Secured Note in whole or in part,  then upon
each such repayment, Pledgee is authorized to deliver to itself for cancellation
that number of Pledged Shares, determined as follows:

                              P = principal paid x .025

                                    where



                 P = the number of Pledged  Shares to be  cancelled by Pledgee

Upon any such  repayment  Pledgee  shall  release to Pledgor a number of Pledged
Shares (the "Released Shares"), determined as follows:

                                       4

<PAGE>


                Released Shares = Principal Paid x 1,882,500 - P
                                  --------------
                                  5,994,000
Where: P is determined as above
            Principal  Paid = the amount of the principal on the Note repayed in
such payment.


     7. Release.

         (a) In  exchange  for the  benefits  provided  hereunder,  Pledgor  and
Pledgee  hereby  release  each other and their  respective  members,  directors,
officers, employees, agents, attorneys, legal successors and assigns of and from
any and all claims,  actions and causes of action, whether now known or unknown,
which either now has, or at any other time had, or shall or may have against the
other  based upon or arising  out of any  matter,  cause,  fact,  thing,  act or
omission whatsoever  occurring or existing at any time to and including the date
hereof,  including,  but not limited to, breach of contract,  tort claims of any
type or wrongful  termination (the "Released Matters") with the exception of the
following  claims:  those  arising  under this  Agreement or referred to herein,
including  Section 5 hereof,  and those  relating to  repayment  of  outstanding
debts.

         (b) It is the intention of the parties in executing this Agreement, and
in giving and receiving the  consideration  called for by this  Agreement,  that
this  Agreement  shall be effective as a full and final accord and  satisfaction
and mutual general release of and from all of the Released Matters.

         (c) In  furtherance  of the  intentions  set forth herein,  each of the
parties hereto  acknowledges  that it is familiar with Section 1542 of the Civil
Code of the State of California, which provides as follows:

         "A general  release does not extend to claims  which the creditor  does
         not know or suspect to exist in his favor at the time of executing  the
         release,  which  if  known by him must  have  materially  affected  his
         settlement with the debtor."

         (d) Each of the parties  hereto  waives and  relinquishes  any right or
benefit  which it has or may have  under  Section  1542 of the Civil Code of the
State of  California or any similar  provision of the statutory or  nonstatutory
law of any other jurisdiction, to the full extent that it may lawfully waive all
such rights and benefits pertaining to the subject matter of this Agreement.  In
connection  with such  waiver and  relinquishment,  each of the  parties  hereto
acknowledges  that it is  aware  that it or its  attorneys  or  accountants  may
hereafter  discover claims or facts in addition to or different from those which
it now knows or  believes to exist with  respect to the  subject  matter of this
Agreement  or the other  parties  hereto,  but that it is its  intention  hereby
fully,  finally and forever to settle and  release all of the  Released  Matters
which now exist,  may exist or heretofore have existed  between them,  except as
otherwise  expressly  provided.  In furtherance of this intention,  the releases
herein given shall be and remain in effect as full and complete  mutual  general
releases  notwithstanding  the discovery or existence of any such  additional or
different claims or facts.

                                       5

<PAGE>


     8. No  Disparagement.  Each  party  agrees not to make  public  disparaging
remarks regarding the other.

     9.  Authorization  of Pledgee Action.  Pledgor  irrevocably  authorizes and
empowers  Pledgee,  at any time and from  time to time,  without  notice  and at
Pledgor's expense, either in its own name or in Pledgor's name, to:

         (a) collect by legal  proceedings  or otherwise all  dividends  (except
cash dividends other than liquidating dividends),  interest,  principal payments
and other  sums now or  hereafter  payable  upon or on  account  of the  Pledged
Collateral;

         (b)  demand,  collect,  and  receive  payment  of any and all monies or
proceeds represented by, or due with respect to, the Pledged Collateral;

         (c) enter  into any  extension,  reorganization,  deposit,  merger,  or
consolidation  agreement,  or any  agreement in any way relating to or affecting
the  Pledged  Collateral,  and in  connection  therewith  Pledgee may deposit or
surrender control of such Pledged Collateral  thereunder,  accept other property
in exchange for such Pledged  Collateral and do and perform such acts and things
as it may deem proper,  and any money or property  received in exchange for such
Pledged  Collateral shall be applied to the indebtedness  under the Secured Note
or thereafter held by it Pledgee to the provisions hereof;

         (d) insure, possess and preserve the Pledged Collateral;

         (e) cause the Pledged  Collateral to be  transferred  to its name or to
the name of its nominee;

         (f) exercise as to such Pledged Collateral all the rights,  powers, and
remedies  of an owner,  except  that so long as the  indebtedness  due under the
Secured Note is not in default  Pledgor shall retain all voting rights as to the
Pledged Collateral.

         (g) deal in all  respects  with the  Pledged  Collateral  as the holder
thereof,  and  Pledgor  irrevocably  constitutes  and  appoints  Pledgee  as its
attorney to do any and all things Pledgee deems necessary or desirable to effect
this Agreement and the Secured Note and the enforcement of Pledgee's  rights and
remedies hereunder and thereunder.

     10.  Expenses.  All  advances,   charges  costs  and  expenses,   including
reasonable attorneys' fees, incurred or paid by Pledgee in exercising any right,
power or remedy  conferred by this  agreement,  or in the  enforcement  thereof,
shall become a part of the  indebtedness  due under the Secured Note and secured
hereunder  and shall be paid to Pledgee by the Pledgor  immediately  and without
demand.

     11.  Default.  At the option of Pledgee and without  necessity of demand or
notice,  all or any part of the  indebtedness  due under the Secured  Note shall
immediately become due and payable irrespective of any agreed maturity, upon the
happening of any of the following events:

                                       6

<PAGE>


         (a) failure to keep or perform any of the terms or  provisions  of this
Agreement not cured within ten (10) days of written notice of such failure ;

         (b) default in the payment of principal  or interest  under the Secured
Note when due if not cured within ten (10) days of notice of such default;

         (c) the levy of any attachment,  execution or other process against the
Pledged Collateral; or

         (d)  the  insolvency,  commission  of an  act  of  bankruptcy,  general
assignment for the benefit of creditors, filing of any petition in bankruptcy or
for relief under the provisions of Title 11, United States Code, Bankruptcy, of,
by or against Pledgor.

     12. Foreclosure.  In the event Pledgee forecloses hereunder,  Pledgee shall
be entitled to the economic  benefits of Section 6 if and to the extent the fair
market value of stock at the time is above $3.16.

     13. Proceeds of Foreclosure. The proceeds of the sale of any of the Pledged
Collateral  and all sums  received or collected by Pledgee from or on account of
the  Pledged  Collateral  shall  first be applied  by Pledgee to the  payment of
expenses  incurred or paid by Pledgee in connection  with any sale,  transfer or
delivery  of the  Pledged  Collateral  and to the  payment  of any other  costs,
charges,  attorneys' fees or expenses  mentioned herein, and then to the payment
of the  indebtedness  under the  Secured  Note or any part  hereof.  Thereafter,
Pledgee shall pay any remaining balance to the Pledgor.

     14. No  Presentment,  No Demands,  etc.  Pledgee  shall be under no duty or
obligation   whatsoever  to  make  or  give  any   presentations,   demands  for
performance, notices of non-performance, protests, notices of protest or notices
of dishonor in  connection  with the Secured  Note or any other  obligations  or
evidences of indebtedness  held by Pledgee as collateral,  or in connection with
the Secured Note or any other any other obligations or evidences of indebtedness
which constitute in whole or in part the indebtedness secured hereunder.

     15.  Rights and Remedies  Not  Exclusive.  The rights,  powers and remedies
given to Pledgee by this  Agreement  shall be in addition to all rights,  powers
and remedies  given to Pledgee by virtue of any statute or rule of law.  Pledgee
may  exercise  its  Pledgee's  lien or  right  of set off  with  respect  to the
indebtedness  due  under  the  Secured  Note  in  the  same  manner  as  if  the
indebtedness  due under the Secured  Note were  unsecured.  Any  forbearance  or
failure or delay by Pledgee in exercising any right,  power or remedy  hereunder
shall  not be  deemed to be a waiver of such  right,  power or  remedy,  and any
single or partial  exercise of any right,  power or remedy  hereunder  shall not
preclude the further  exercise  thereof;  and every  right,  power and remedy of
Pledgee  shall  continue  in full force and effect  until such  right,  power or
remedy is specifically waived by an instrument in writing executed by Pledgee.

     16.  Release of Pledged  Collateral.  The pledge of and grant of a security
interest in the Pledged  Collateral  pursuant to this  Agreement  shall be of no
further  force or effect and subject to Section 6 any  remaining  portion of the
Pledged  Collateral shall be returned to Pledgor upon the

                                       7

<PAGE>


payment in full of the Secured  Note to Pledgee;  provided,  however,  that this
Agreement shall be reinstated if any payment must be returned by Pledgee for any
reason, including, but not limited to, upon or after the insolvency,  bankruptcy
or reorganization of Pledgor.

     17.  Notice.  Unless  otherwise  set forth  herein,  all notices,  demands,
requests and other written  communications  hereunder  shall be given to Pledgee
and/or Pledgor by regular United States mail,  postage  prepaid and addressed as
follows:

     If to Pledgee:                     SciClone Pharmaceuticals, Inc.
                                        901 Mariners Island Boulevard
                                        San Mateo, California  94404
                                        Telephone:  (415) 358-3456
                                        Attn:  Mark A. Culhane

     If to
     Pledgor:                           Thomas E. Moore
                                        26201 Dori Lane
                                        Los Altos Hills, California 94022
                                        Telephone:  (415) 949-3519

Any notice  given in the manner  aforesaid  shall be deemed to have been served,
and shall be effective for all purposes hereof,  on the earlier of the third day
following  the day on which it is posted or the date of its receipt by the party
to be  notified  and to  prove  the  service  of any  such  notice  it  shall be
sufficient  to prove that the same was properly  address and posted as aforesaid
or actually  received by any party to whom such notice was  delivered in person.
Pledgor  and  Pledgee  shall each have the right to change its  address  for the
purpose of this  Agreement by giving at least three (3) days' written  notice of
any such change to the other party hereto.

     18.  Governing  Law.  This  Agreement  shall be governed by the laws of the
State of California, without giving effect to conflicts of law principles.

     19.  Waiver of Jury Trial.  PLEDGOR AND PLEDGEE EACH HEREBY WAIVE ANY RIGHT
TO  TRIAL  BY JURY OF ANY  CLAIM,  DEMAND,  ACTION,  CAUSE  OF  ACTION,  SUIT OR
PROCEEDINGS (A) ARISING UNDER THIS AGREEMENT OR ANY OTHER INSTRUMENT,  DOCUMENT,
OR  AGREEMENT  EXECUTED OR DELIVERED  IN  CONNECTION  HEREWITH OR (B) IN ANY WAY
CONNECTED WITH OR RELATED TO OR INCIDENTAL TO THE DEALINGS OF THE PARTIES HERETO
OR ANY OF THEM WITH RESPECT TO THIS AGREEMENT,  THE REIMBURSEMENT  AGREEMENT, OR
ANY OTHER INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION
HEREWITH OR THE TRANSACTIONS  RELATED HERETO,  IN EACH CASE WHETHER NOW EXISTING
OR  HEREAFTER  ARISING,  AND WHETHER  SOUNDING IN CONTRACT,  TORT OR  OTHERWISE.
PLEDGOR  AND PLEDGEE  HEREBY  AGREE AND  CONSENT  THAT ANY SUCH  CLAIM,  DEMAND,
ACTION,  CAUSE OF ACTION,  SUIT OR PROCEEDING SHALL BE DECIDED BY A COURT TRIAL,
WITHOUT A JURY,  AND THAT EITHER PARTY MAY FILE AN ORIGINAL  COUNTERPART OR COPY
OF THIS  AGREEMENT  WITH ANY COURT AS

                                       8

<PAGE>


WRITTEN  EVIDENCE OF THE  CONSENT OF THE  PARTIES  HERETO TO THE WAIVER OF THEIR
RIGHT TO TRIAL BY JURY.

     20. Miscellaneous.

         (a) This  Agreement may not be amended or modified  except by a written
instrument signed by Pledgee and Pledgor.

         (b) This Agreement constitutes the entire agreement between Pledgee and
Pledgor  with  respect to the  subject  matter  hereof and  supersede  all prior
agreements, understandings, offers and negotiations, oral or written, including,
but not limited to, the Unsecured Note, that certain  Agreement dated as of July
10,  1997 by and  between  the  Seller  and the  Company,  that  certain  Letter
Agreement  regarding  Registration Rights Agreement dated as of July 10, 1997 by
and between the Seller and the Company,  all of which shall be terminated and be
of no further force and effect upon the  satisfaction  of the obligations of the
parties set forth in Section 1 of this Agreement.

         (c) This Agreement may be executed in one or more counterparts, each of
which shall be deemed an original,  but all of which shall  together  constitute
one and the same document.

                                       9

<PAGE>


     IN WITNESS WHEREOF, the parties hereto have executed this Agreement the day
and year first above written.

                                                  "PLEDGOR"


                                                  /s/ Thomas Moore
                                                  ------------------------------
                                                  Thomas Moore



                                                  "PLEDGEE"

                                                  SCICLONE PHARMACEUTICALS, INC.



                                                  /s/ Mark A. Culhane
                                                  ------------------------------
                                                  Mark A. Culhane
                                                  Chief Financial Officer



     The parties  agree to review the terms above to ensure they are  consistent
and accurate and to promptly agree in good faith upon any changes  necessary for
accuracy or consistency.


                                 [INITIALED BY THOMAS MOORE AND MARK A. CULHANE]

                                       10



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