INVESCO GLOBAL HEALTH SCIENCES FUND
N-2, 1999-04-07
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           AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON APRIL 7, 1999

                                                  1933 ACT FILE NO.  33-        
                                                  1940 ACT FILE NO.  811-6476

                     U.S. SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM N-2

[X]  REGISTRATION  STATEMENT  UNDER THE SECURITIES ACT OF 1933 
[ ]  Pre-Effective Amendment No.
[ ]  Post-Effective Amendment No.

                                       AND

[X]  REGISTRATION STATEMENT UNDER THE INVESTMENT COMPANY ACT OF 1940
[X]  Amendment No. 1

                       INVESCO GLOBAL HEALTH SCIENCES FUND
                             7800 EAST UNION AVENUE
                             DENVER, COLORADO 80237
                                1-303-930-6300

                               Glen A. Payne, Esq.
                                 General Counsel
                            INVESCO Funds Group, Inc.
                         7800 E. Union Avenue, Suite 800
                             Denver, Colorado 80237

                                   COPIES TO:

             Thomas A. Hale                       Clifford J. Alexander
         Skadden, Arps, Slate,                 Kirkpatrick & Lockhart LLP
       Meagher & Flom (Illinois)                1800 Massachusetts Avenue
      333 Wacker Drive, Suite 2100                    Second Floor
        Chicago, Illinois 60606                   Washington, DC 20036

APPROXIMATE DATE OF PROPOSED PUBLIC OFFERING:  As soon as practicable  after the
effective date of this Registration Statement.

      If any  securities  being  registered  on this form will be  offered  on a
delayed or continuous  basis in reliance on Rule 415 under the Securities Act of
1933, other than securities  offered in connection with a dividend  reinvestment
plan, check the following box. [ ]

<PAGE>

        CALCULATION OF REGISTRATION FEE UNDER THE SECURITIES ACT OF 1933

                                                       PROPOSED
                                       PROPOSED        MAXIMUM
                                        MAXIMUM       AGGREGATE      AMOUNT OF
TITLE OF SECURITIES   AMOUNT BEING  OFFERING PRICE     OFFERING    REGISTRATION
 BEING REGISTERED     REGISTERED(1)    PER UNIT(2)      PRICE(2)       FEE(2)
- --------------------------------------------------------------------------------

Shares of             
Beneficial Interest
Issuable Upon
Exercise of Rights     1 million        $19 3/16        $19,187,500     $5334.13
to Subscribe for         shares
Such Shares
- --------------------------------------------------------------------------------

(1) Includes [     ] total  shares  of beneficial  interest to cover an increase
    by the  Registrant  of 25% of the  number of shares of  beneficial  interest
    subject to subscriptions.

(2) Estimated  solely for the purpose of  calculating  the  registration  fee in
    accordance with Rule 457(c) under the Securities Act of 1933 on the basis of
    the average of the high and low sales prices for the Fund's shares  reported
    on the New York Stock Exchange on April 1, 1999.

THE REGISTRANT HEREBY AMENDS THIS  REGISTRATION  STATEMENT ON SUCH DATE OR DATES
AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE  DATE UNTIL  REGISTRANT  SHALL FILE A
FURTHER AMENDMENT WHICH  SPECIFICALLY  STATES THAT THIS  REGISTRATION  STATEMENT
SHALL  THEREAFTER  BECOME  EFFECTIVE  IN  ACCORDANCE  WITH  SECTION  8(a) OF THE
SECURITIES ACT OF 1933, AS AMENDED,  OR UNTIL THE  REGISTRATION  STATEMENT SHALL
BECOME EFFECTIVE ON SUCH DATE AS THE SECURITIES AND EXCHANGE COMMISSION,  ACTING
PURSUANT TO SECTION 8(a), MAY DETERMINE.


                                       ii
<PAGE>


                       INVESCO GLOBAL HEALTH SCIENCES FUND
                              CROSS-REFERENCE SHEET

PART A

ITEM
NO.        CAPTION                                LOCATION IN PROSPECTUS
- ---        -------                                ----------------------

1.         Outside Front Cover                    Front Cover Page.

2.         Inside Front and Outside Back Cover    Front Cover Page.
           Page

3.         Fee Table and Synopsis                 Prospectus Summary; and Fee
                                                  Table.

4.         Financial Highlights                   Financial Highlights.

5.         Plan of Distribution                   Front Cover Page; Prospectus
                                                  Summary; The Offer; Dividends
                                                  and Other Distributions; and
                                                  Dividend Reinvestment and
                                                  Cash Purchase Plan.

6.         Selling Shareholders                   Not Applicable.

7.         Use of Proceeds                        Prospectus Summary; and Use
                                                  of Proceeds.

8.         General Description of the Registrant  Front Cover Page; Prospectus
                                                  Summary; Financial Highlights
                                                  - Portfolio Characteristics
                                                  and Composition; Trading and
                                                  Net Asset Value Information;
                                                  The Fund; The Offer;
                                                  Description of Shares of
                                                  Beneficial Interest;
                                                  Investment Objective and
                                                  Policies; Risk Factors and
                                                  Special Considerations;
                                                  Investment Restrictions; and
                                                  Special Investment Practices.

9.         Management                             Prospectus Summary;
                                                  Management of the Fund; and
                                                  Custodian, Transfer Agent,
                                                  Dividend Disbursing Agent,
                                                  and Registrar.

10.        Capital Stock, Long-Term Debt, and     Front Cover Page; Description
           Other Securities                       of Shares of Beneficial
                                                  Interest; Dividends and Other
                                                  Distributions; Dividend
                                                  Reinvestment and Cash Purchase
                                                  Plan; and Federal Taxation Of
                                                  The Fund And Its Shareholders.

11.        Defaults and Arrears on Senior         Not Applicable.
           Securities

12.        Legal Proceedings                      Not Applicable.

13.        Table of Contents of the Statement of  Table of Contents of
           Additional Information                 Statement of Additional
                                                  Information.

PART B

ITEM                                              LOCATION IN STATEMENT OF
NO.        CAPTION                                ADDITIONAL INFORMATION
- ---        -------                                ----------------------

14.        Cover Page                             Cover Page.

15.        Table of Contents                      Table of Contents.

16.        General Information and History        General Information.


                                       iii
<PAGE>
ITEM                                               LOCATION IN STATEMENT OF
NO.        CAPTION                                 ADDITIONAL INFORMATION
- ---        -------                                 ----------------------

17.        Investment Objective and Policies       Additional Information About
                                                   Its Investment Objective and
                                                   Policies; Investment
                                                   Restrictions.

18.        Management                              Management.

19.        Control Persons and Principal Holders   Ownership of Shares; and
           of Securities                           Prospectus: Description of
                                                   Shares of Beneficial
                                                   Interest.

20.        Investment Advisory and Other Services  Management; Financial
                                                   Statements; Prospectus:
                                                   Management of the Fund;
                                                   Prospectus: Custodian,
                                                   Transfer Agent, Dividend
                                                   Disbursing Agent, and
                                                   Registrar; and Prospectus:
                                                   Independent Accountants.

21.        Brokerage Allocation and Other          Portfolio Transactions;
           Practices                               Prospectus: Portfolio
                                                   Trading; and Prospectus:
                                                   Special Investment Practices.

22.        Tax Status                              Taxation.

23.        Financial Statements                    Financial Statements.

PART C

Information required to be included in Part C is set forth under the appropriate
item, so numbered, in Part C of this Registration Statement.






                                       iv
<PAGE>

                             SUBJECT TO COMPLETION
                   PRELIMINARY PROSPECTUS DATED      , 1999


                       INVESCO GLOBAL HEALTH SCIENCES FUND

                     [       ] SHARES OF BENEFICIAL INTEREST
                        ISSUABLE UPON EXERCISE OF RIGHTS
                          TO SUBSCRIBE FOR SUCH SHARES

INVESCO  Global Health  Sciences  Fund (the "Fund") is issuing  non-transferable
rights ("Rights") to those shareholders that are shareholders of record ("Record
Date  Shareholders") as of the close of business on [ 1999] (the "Record Date").
These Rights will allow  Record Date  Shareholders  to  subscribe  for shares of
beneficial  interest  of the Fund  ("Shares").  Record  Date  Shareholders  will
receive one Right for every [X#] outstanding Shares they own on the Record Date.
For every one Right that Record Date Shareholders  receive, they may buy one new
Share. If they own less than [X#] outstanding  Shares,  they will be entitled to
one Right to buy one Share.  Also,  Record Date Shareholders who exercise all of
their  Rights may  request to  subscribe  for the Shares not  acquired  by other
Record  Date   Shareholders  in  this  Rights  offering  (the  "Offer"  or  this
"Offering"),  subject  to the  limitations  discussed  in this  prospectus  (the
"Prospectus"). The Fund may increase the number of Shares that may be subscribed
for  in  this  Offering  by up to  25%  of the  Shares  offered  in the  Primary
Subscription  (defined  below),  or up to an additional [      ] Shares,  for an
aggregate  total of [        ] Shares,  to honor such  requests  for  additional
Shares. The Offer will expire at 5:00 P.M., Eastern Time, on [ 1999],  unless it
is extended as described in this Prospectus (the "Expiration Date").

The Rights are  non-transferable  and therefore may not be  transferred or sold.
The Rights will not be admitted for trading on the New York Stock  Exchange (the
"NYSE")  or any other  stock  exchange.  The  currently  outstanding  Shares are
listed, and the Shares issued in this Offering will be listed, on the NYSE under
the symbol  "GHS." On [ 1999],  the last  reported  net asset value  ("NAV") per
Share was $[ . ] and  the last  reported sales  price of a Share on the NYSE was
$[    ].

THE  PURCHASE  PRICE PER SHARE (THE  "SUBSCRIPTION  PRICE") WILL BE [XX%] OF THE
LOWER OF: (1) THE AVERAGE OF THE LAST REPORTED SALES PRICE PER SHARE ON THE NYSE
ON THE EXPIRATION  DATE AND ON THE PRECEDING FOUR BUSINESS DAYS; OR (2) THE LAST
REPORTED NAV PER SHARE ON THE EXPIRATION DATE.

                        ---------------------------------

NEITHER THE SECURITIES  AND EXCHANGE  COMMISSION  (THE "SEC" OR  "COMMISSION")
NOR ANY STATE  SECURITIES  COMMISSION  HAS  APPROVED OR  DISAPPROVED  OF THESE
SECURITIES  OR  DETERMINED  THE ACCURACY OR ADEQUACY OF THIS  PROSPECTUS.  ANY
REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

                    -----------------------------------------

                                              PER SHARE    TOTAL
               Estimated Subscription Price
               Sales Load
               Proceeds to the Fund

     The  estimated  subscription  price  in the  table  above  (the  "Estimated
     Subscription  Price")  is  estimated  on the basis of [XX%] of the [NAV per
     ("Proceeds") Share/last sale price per Share on the NYSE] on [ , 1999]. The
     proceeds to the Fund  assumes all [         ] Shares are  purchased  at the
     Estimated  Subscription  Price.  If the Fund increases the number of Shares
     subject to subscription by 25% as described above, the Proceeds to the Fund
     would be $[   ].

<PAGE>

The Fund is a diversified  closed-end  management  investment company registered
under the  Investment  Company Act of 1940,  as amended  (the "1940  Act").  The
Fund's  investment  objective  is to  seek  capital  appreciation  by  investing
substantially  all of its assets in equity and related  securities  of U.S.  and
foreign  companies  principally  engaged in the  development or  distribution of
products or services relating to the health sciences.  INVESCO Funds Group, Inc.
(the "Investment Manager" or "INVESCO"),  an indirect wholly owned subsidiary of
AMVESCAP PLC, serves as investment adviser to the Fund.

Record Date  Shareholders  who do not exercise  their Rights  should expect that
they will, at the completion of the Offer, own a smaller  proportional  interest
in the Fund than they would if they exercised their Rights. In addition, because
the  Subscription  Price  per  Share  will be less than the NAV per Share on the
Expiration  Date,  they will  experience an immediate  dilution,  which could be
significant,   of  the  aggregate  NAV  of  their  Shares.  This  dilution  will
disproportionately  affect Record Date  Shareholders  who do not exercise  their
Rights in full.  The Fund cannot state  precisely the extent of this dilution at
this time because the Fund does not know what the NAV per Share will be when the
Offer  expires,  what the  Subscription  Price will be, the extent of the Fund's
expenses  that  will  be  incurred  or what  proportion  of the  Rights  will be
exercised. See "Risk Factors and Special Considerations--Dilution."

This  Prospectus  sets forth  concisely  the  information  about the Fund that a
prospective  investor ought to know before  investing.  Investors are advised to
read and retain it for future reference.  A Statement of Additional  Information
(the "SAI") dated [  ] containing additional information about the Fund has been
filed with the SEC and is  incorporated  by reference in its entirety  into this
Prospectus. A copy of the SAI, the table of contents of which appears on page 52
of this  Prospectus,  may be  obtained  without  charge by  calling  the Fund at
1-800-528-8765  or by contacting  the Fund at 7800 E. Union  Avenue,  Suite 800,
Denver,  Colorado  80237.  A copy of the SAI also may be obtained from the SEC's
website at  http://www.sec.gov in addition to other material incorporated herein
by reference and other information  regarding registrants that file with the SEC
electronically.

                          ---------------------------

                            PAINEWEBBER INCORPORATED

                          ---------------------------

                 THE DATE OF THIS PROSPECTUS IS [      ], 1999.





                                       ii
<PAGE>


                               PROSPECTUS SUMMARY

      THIS SUMMARY  HIGHLIGHTS  SOME  INFORMATION  THAT IS DESCRIBED  MORE FULLY
ELSEWHERE IN THIS PROSPECTUS.  IT MAY NOT CONTAIN ALL OF THE INFORMATION THAT IS
IMPORTANT  TO YOU. TO  UNDERSTAND  THE OFFER  FULLY,  YOU SHOULD READ THE ENTIRE
DOCUMENT  CAREFULLY,  INCLUDING THE RISK FACTORS UNDER THE HEADING "RISK FACTORS
AND SPECIAL CONSIDERATIONS."

PURPOSE OF THE OFFER       The  Board of  Trustees  of the Fund  (the  "Board of
                           Trustees"  or the  "Board")  has  determined  that it
                           would  be in the best  interests  of the Fund and its
                           existing  shareholders  to increase the Fund's assets
                           so  that  it  may be in a  better  position  to  take
                           advantage of  investment  opportunities  and increase
                           the  diversification  of its  portfolio  fully  while
                           achieving other net benefits to the Fund.

                           In reaching  its  decision to approve the Offer,  the
                           Board of Trustees  considered,  among  other  things,
                           advice   by   the   Investment   Manager   that   the
                           availability  of new assets  would enable the Fund to
                           pursue   attractive   investments   without   selling
                           portfolio  securities.  In  addition,  the  Board  of
                           Trustees  considered  that a  rights  offering  could
                           result in more  liquidity for the Shares,  would give
                           shareholders  the opportunity to purchase Shares at a
                           price  below  market  value per Share  and/or NAV per
                           Share,   and  might  increase  the  level  of  market
                           interest in the Fund.  The Board also  believes  that
                           this  Offer may result in a nominal  decrease  in the
                           Fund's operating  expense ratio.  This is because the
                           Fund's  fixed costs can be spread over a larger asset
                           base.  In  addition,  the  Fund  and  the  Investment
                           Manager  recently  agreed to add a breakpoint  to the
                           investment  management agreement for assets in excess
                           of $500  million.  At the Fund's  current asset size,
                           substantially  all of the proceeds of the Offer would
                           be managed at this  lower fee,  which  would have the
                           effect of lowering the Fund's overall expense ratio.

                           In  determining  that  the  Offer  was  in  the  best
                           interests of the Fund and its shareholders, the Board
                           of Trustees  retained  PaineWebber  Incorporated (the
                           "Dealer  Manager") to provide the Fund with financial
                           advisory  and  marketing  services  relating  to  the
                           Offer,  including the structure,  timing and terms of
                           the Offer. In addition to the foregoing, the Board of
                           Trustees considered, among other things, the benefits
                           and drawbacks of conducting a non-transferable versus
                           a transferable  rights offering,  the possible impact
                           of the Offer on market price volatility, its dilutive
                           effect,  its effect on  non-exercising  shareholders,
                           the   effect   on   the   Fund   if  the   Offer   is
                           under-subscribed,  and the  experience  of the Dealer
                           Manager in conducting rights offerings.


                                       1
<PAGE>
<TABLE>
<CAPTION>

<S>                             <C>                                        <C>

IMPORTANT TERMS OF THE OFFER     Total number of Shares offered:            [        ]*

                                 Number of non-transferable                 One Right for every [X#] 
                                 Rights issued to each Record Date          Shares owned on the Record
                                 Shareholder:                               Date

                                 Subscription ratio:                        One Share for every one 
                                                                            Right

                                 Subscription Price:                        [XX%] of the lower of
                                                                            (1) the average of
                                                                            the last reported
                                                                            sales price per Share 
                                                                            on the NYSE on the  
                                                                            Expiration Date and  
                                                                            on the preceding four 
                                                                            business days** or 
                                                                            (2) the NAV per Share
                                                                            on the Expiration Date

                                 Expiration Date:                           The Offer will expire
                                                                            at 5:00 P.M. Eastern
                                                                            time on [       ], 1999,
                                                                            unless the Offer is
                                                                            extended to a date no
                                                                            later than [      ], 1999

                                 *  Includes [       ] Shares  that the Fund may  issue to cover over-
                                 subscription requests.

                                 **  "Business  Day" means a day on which the NYSE is open for trading
                                 and which is not a  Saturday  or Sunday or a holiday,  including  New
                                 Year's Day,  Martin  Luther  King,  Jr. Day,  Presidents'  Day,  Good
                                 Friday,  Memorial Day,  Independence  Day,  Labor Day,  Columbus Day,
                                 Thanksgiving  Day,  Christmas  Day or any other day on which banks in
                                 New York City are  authorized or obligated by law or executive  order
                                 to close.

OVER-SUBSCRIPTION PRIVILEGE      Record Date  Shareholders who fully exercise all of the  Rights issued
                                 to them are entitled to request to subscribe for those Shares  offered
                                 hereby  that were not bought by other  Record  Date  Shareholders.  If
                                 enough  Shares are  available,  all such  requests  will be honored in
                                 full. If such  requests for Shares  exceed the Shares  available,  the
                                 Fund may, at the discretion of the Board of Trustees,  issue Shares up
                                 to an additional 25% of the Shares available pursuant to the Offer (up
                                 to an  additional [       ] Shares) in order to cover  such  requests.
                                 Regardless of whether the Fund issues such additional  Shares,  and to
                                 the  extent  Shares  are not  available  to honor  all  requests,  the
                                 available   Shares  will  be  allocated   PRO  RATA  among  those  who
                                 over-subscribe based on the number of Rights originally issued to them
                                 by the Fund.


                                                  2
<PAGE>


IMPORTANT DATES TO REMEMBER    EVENT                                          DATE
                               -----                                          ----

                               Record Date                                    [            ]

                               Subscription Period                            [            ]*

                               Expiration Date and Pricing Date               [            ]*

                               Subscription Certificates and Payment          [            ]* 
                               for Shares Due** 

                               Notice of Guaranteed Delivery Due              [            ]* 

                               Payment for Guarantees of Delivery Due         [            ]*  

                               Confirmation Mailed to Participants            [            ]*  

                               Final Payment for Shares***                    [            ]* 

                               * Unless the Offer is extended.

                               **A  Record Date  Shareholder  exercising  Rights  must  deliver by the
                                 Expiration Date either (i) a Subscription Certificate (defined below) 
                                 and payment for Shares  or  (ii)  a  Notice  of  Guaranteed  Delivery 
                                 (defined  below).
                                   
                               ***Additional  amount due (in the event the  Subscription  Price exceeds
                                  the Estimated Subscription Price).

NON-TRANSFERABILITY OF RIGHTS    The Rights are non-transferable and, therefore,  may not be purchased
                                 or sold. The Rights will not be listed for trading on the NYSE or any
                                 other securities exchange.  However, the Shares to be issued pursuant
                                 to the Offer  will be listed  for  trading  on the NYSE,  subject  to
                                 notice of issuance.

METHOD OF EXERCISING             Except as described below,  subscription  certificates evidencing the
   RIGHTS                        Rights (the "Subscription  Certificates") will be sent to Record Date
                                 Shareholders  or their nominees.  If a Record Date Shareholder wishes 
                                 to exercise Rights, the shareholder may do so in the following ways:

                                 (1) Record Date  Shareholders  or their nominees  should complete and
                                 sign the Subscription  Certificate.  Mail it in the envelope provided
                                 or deliver the completed  and signed  Subscription  Certificate  with
                                 payment in full to  EquiServe,  Inc. at the address  indicated on the
                                 Subscription   Certificate.   A  completed  and  signed  Subscription
                                 Certificate and payment must be received by the Expiration Date; or
                                 (2) Contact your broker, banker or trust company,  which can arrange,


                                                  3
<PAGE>

                                 on your behalf, to guarantee delivery by the close of business on the
                                 third  Business  Day after the Expiration  Date, payment and delivery
                                 of  a  properly  completed  and  executed  Subscription   Certificate
                                 pursuant to a notice of  guaranteed  delivery  ("Notice of Guaranteed
                                 Delivery").  A fee may be  charged  for this  service.  The Notice of
                                 Guaranteed  Delivery  must be  received  on or before the  Expiration
                                 Date.

OFFERING FEES AND EXPENSES       The Fund has agreed to pay the Dealer Manager a fee ("Dealer  Manager
                                 Fee") for its  financial  advisory and  marketing  services  equal to
                                 [1.25%] of the  aggregate  Subscription  Price for each Share  issued
                                 pursuant  to  the  Offer,  and  the  Fund  has  also  agreed  to  pay
                                 broker-dealers,   including  the  Dealer  Manager,   fees  for  their
                                 solicitation   efforts   ("Solicitation   Fees")   of  2.50%  of  the
                                 Subscription  Price per Share for each Share  issued  pursuant to the
                                 Offer. Solicitation Fees will be paid to the broker-dealer designated
                                 on the applicable portion of the Subscription  Certificate or, in the
                                 absence  of any  such  designation,  to  the  Dealer  Manager.  Other
                                 offering  expenses  incurred by the Fund are estimated at [$    ],
                                 which includes up to [$   ] that may be paid to the Dealer Manager as
                                 partial reimbursement for its expenses relating to the Offer.

FOREIGN RESTRICTIONS             Record  Date  Shareholders  whose  record  addresses  are outside the
                                 United  States will  receive  written  notice of the Offer;  however,
                                 Subscription  Certificates  will not be mailed to such  shareholders.
                                 The Rights to which those  Subscription  Certificates  relate will be
                                 held  by  the  subscription   agent  for  such  foreign  Record  Date
                                 Shareholders'  accounts  until  instructions  are received in writing
                                 with  payment to exercise  the Rights.  If no such  instructions  are
                                 received  by the  Expiration  Date,  such  Rights  will  expire.  See
                                 "Subscription  Agent." 

USE  OF  PROCEEDS                If [       ] Shares  are  sold  a  the  Estimated Subscription  Price
                                 of $____ per Share,  net  proceeds of the Offer are  estimated  to be
                                 approximately  $________,  after deducting estimated expenses payable
                                 by the Fund,  including  the fees and expenses of the Dealer  Manager
                                 and  other  offering  expenses  that in  total  are  estimated  to be
                                 $_______.  If the Fund  increases  the  number of Shares  subject  to
                                 subscription  by up to 25%,  or [      ] Shares,  in order to satisfy
                                 over-subscription  requests,  the  additional  net  proceeds  will be
                                 approximately $________.

                                 The Investment  Manager has advised the Fund that it anticipates that
                                 the net proceeds will be invested in accordance  with its  investment
                                 objective and the policies set forth under "Investment  Objective and
                                 Policies"  within three months from the date of this  Prospectus (but
                                 in no event later than six months from the date of this  Prospectus),
                                 depending on market  conditions and the  availability  of appropriate
                                 securities. Pending such investment, the proceeds will be invested in
                                 certain high quality short-term debt instruments, or in certain other
                                 

                                                  4
<PAGE>

                                 investments  (including,   potentially,   futures  contracts  on  the
                                 Standard & Poor's 500 Composite Stock Price Index ("S&P 500 futures")
                                 as described herein under "Investment Objective and Policies--Special
                                 Investment Practices--Hedging."

INFORMATION AGENT                Please direct all questions or inquiries relating to the Offer to the
                                 Fund's information agent as follows:

                                             SHAREHOLDER COMMUNICATIONS CORP.
                                             17 STATE STREET
                                             NEW YORK, NY 10004
                                             (800) 618-7826
                                             BROKERS AND BANKS,  PLEASE CALL (800)  877-8579 EXT. 113

                                 Shareholders may also contact their broker or nominee for information.

INFORMATION REGARDING THE        The Fund is a  diversified, closed-end  management investment company 
  FUND                           registered under the 1940 Act. It is managed by INVESCO. The Fund was
                                 organized as a Massachusetts  business trust on November 18, 1991 and
                                 commenced  investment  operations  on January 24,  1992.  The Fund is
                                 aggressively managed for growth. It seeks to achieve its objective by
                                 investing  its  assets  in a  broad  range  of  health  care  related
                                 equities, such as market-leading  pharmaceutical  companies,  medical
                                 devices manufacturers and suppliers,  biotech companies,  health care
                                 delivery companies,  and various private placement  investments.  The
                                 Fund may further focus its  investments  in certain of these sectors.
                                 For example, at the date of this Prospectus, approximately 60% of the
                                 Fund's   portfolio  is  invested  in  equity   securities   of  large
                                 pharmaceutical  companies.  The Fund may purchase and sell options on
                                 equities. See "The Fund" and "Investment Objective and Policies." For
                                 information  regarding  the  Fund's  portfolio   characteristics  and
                                 composition as of April 30, 1999, see "Portfolio  Characteristics and
                                 Composition."

INFORMATION  REGARDING THE       INVESCO has served as the Fund's  investment  adviser  since February
  MANAGER                        4, 1998. INVESCO determines the  composition of the Fund's portfolio,
                                 places all orders for the  purchase  and sale of  securities  and for
                                 other  transactions,  and  oversees  the  settlement  of  the  Fund's
                                 securities and other  portfolio  transactions.  INVESCO also provides
                                 administrative  services  to the Fund.  These  include,  among  other
                                 things,  providing officers and office space,  preparing or assisting
                                 in preparing  materials for  shareholders  and regulatory  bodies and
                                 overseeing  the  provision  to the Fund of custodial  and  accounting
                                 services.

                                 As  compensation  for its services to the Fund,  INVESCO  receives an
                                 investment  management fee that accrues daily at the applicable  rate
                                 and is paid monthly.  On February 3, 1998,  the Board of Trustees and
                                 

                                                  5
<PAGE>

                                 INVESCO agreed to add a breakpoint to the investment  management fee,
                                 such that the Fund pays  INVESCO a fee at the annual rate of 1.00% on
                                 ending daily net assets up to and including  $500 million,  and 0.90%
                                 on ending daily net assets in excess of $500  million.  Additionally,
                                 in accordance with an administrative agreement, the Fund pays INVESCO
                                 a monthly fee at the annual rate of 0.10% on ending  daily net assets
                                 for administrative services. Prior to February 4, 1998, INVESCO Trust
                                 Company ("ITC"),  then a wholly-owned  subsidiary  of INVESCO, served 
                                 as the Fund's investment adviser.

RISK FACTORS AND SPECIAL         The   following   summarizes   some  of  the  matters  that you should
  CONSIDERATIONS                 consider before investing in the Fund through this Offer.  Please see
                                 "Risk Factors and Special  Considerations"  of this  Prospectus for a
                                 more complete discussion of these matters.

                                 DILUTION.  Record Date  Shareholders  will  experience  an  immediate
                                 dilution  of the  aggregate  NAV of their  Shares  as a result of the
                                 Offer. This is because the Subscription  Price per Share will be less
                                 than the NAV per Share on the  Expiration  Date,  the Fund will incur
                                 expenses  in  connection  with the  Offer,  and the  number of Shares
                                 outstanding  after the Offer will  increase  in a greater  percentage
                                 than the  increase in the size of the Fund's  assets.  This  dilution
                                 will affect those shareholders more that do not exercise their Rights
                                 in full. In addition,  if  shareholders  do not fully  exercise their
                                 Rights,  they should expect that they will, as a result of and at the
                                 completion of the Offer, own a smaller  proportional  interest in the
                                 Fund than would otherwise be the case. Although it is not possible to
                                 state  precisely the amount of any dilution,  because it is not known
                                 at this time what the NAV per Share will be on the Expiration Date or
                                 what  proportion  of the  Rights  will  be  exercised,  or  what  the
                                 Subscription Price will be, such dilution could be significant. For a
                                 more detailed discussion about dilution, please see "Risk Factors and
                                 Special Considerations--Dilution."

                                 HEALTH SCIENCE  COMPANIES.  Investment in the securities of companies
                                 principally engaged in the development, production or distribution of
                                 products or services relating to the health sciences ("Health Science
                                 Companies") entails special  considerations and risks. Among these is
                                 the risk that many Health  Science  Companies  may be subject to, and
                                 possibly  adversely  affected by, some of the same trends relating to
                                 the demand for  health-related  products  and  services  and the same
                                 regulatory,  economic and political  factors.  Certain health science
                                 industries and Health Science Companies are characterized by a single
                                 product focus,  rapidly changing  technology or extensive  government
                                 regulation.  Many of these  activities  are funded or  subsidized  by
                                 federal   and  state   governments;   consequently,   withdrawal   or
                                 curtailment  of this  support  could  have an  adverse  impact on the
                                 profitability,  and  market  prices,  of such  companies.  Changes in
                                 government  regulation  could also have an adverse  impact.  Further,
                                 continuing  technological  advances  may mean rapid  obsolescence  of
                                 

                                                  6
<PAGE>
                                 products and services. These regulatory and research developments may
                                 result in abrupt  fluctuations in securities values of Health Science
                                 Companies.  Unanticipated  problems may arise in connection  with the
                                 development  of new products or  technologies,  and many such efforts
                                 may  ultimately be  unsuccessful.  In addition,  testing or marketing
                                 products or technologies may require obtaining government  approvals,
                                 which may be lengthy, expensive processes with uncertain outcomes. As
                                 a result  of these  and  other  factors,  smaller  developing  Health
                                 Science Companies may require additional capital  investments,  which
                                 may dilute the interests of existing investors, such as the Fund. See
                                 "Risk Factors-Health Science Companies."

                                 INVESTMENTS  IN  UNSEASONED  COMPANIES.  The Fund may  invest  in the
                                 securities of smaller, less seasoned companies. These investments may
                                 present  greater  opportunities  for growth but also involve  greater
                                 risks  than  those   customarily   associated  with   investments  in
                                 securities of more established companies.  Some of the Health Science
                                 Companies  in which the Fund may invest  will be  start-up  companies
                                 that may have  insubstantial  operational or earnings  history or may
                                 have limited  products,  markets,  financial  resources or management
                                 depth.  Some may  also be  emerging  companies  at the  research  and
                                 development  stage  with no  products  or  technologies  to market or
                                 approved  for  marketing.   Securities  of  emerging  Health  Science
                                 Companies may lack an active  secondary  market and may be subject to
                                 more abrupt or erratic  price  movements  than  securities of larger,
                                 more  established  companies  or stock  market  averages  in general.
                                 Competitors of certain Health Science Companies, which may or may not
                                 be Health Science Companies, may have substantially greater financial
                                 resources  than many of the  companies  in which the Fund may invest.
                                 See "Risk  Factors-Investments  in  Unseasoned  Companies"  and "Risk
                                 Factors-Illiquid Investments."

                                 SUBSTANTIAL COMPETITION.  Intense competition exists within and among
                                 certain health science  industries,  including  competition to obtain
                                 and  sustain  proprietary  technology   protection.   Health  Science
                                 Companies  may be highly  dependent  on the  strength  of a patent to
                                 maintain  revenues  and  market  share.  The  complex  nature  of the
                                 technologies   involved  can  lead  to  patent  disputes,   including
                                 litigation  that could result in a company losing an exclusive  right
                                 to a patent. See "Risk Factors-Substantial Competition."

                                 PRODUCT  LIABILITY  EXPOSURE.  Certain Health  Science  Companies and
                                 related  companies  in which the Fund may  invest  will be exposed to
                                 potential   liability   risks   that   are   inherent   in   testing,
                                 manufacturing, marketing and selling human therapeutic and diagnostic
                                 products. See "Risk Factors-Product Liability Exposure."

                                 FOREIGN  SECURITIES.  The Fund will invest in  securities  of foreign
                                 issuers  and   securities   traded  in  foreign   markets   ("Foreign
                                 

                                                  7
<PAGE>

                                 Securities"). Investing in Foreign Securities involves considerations
                                 and risks not typically  associated  with  investing in securities of
                                 U.S.  issuers in U.S.  markets.  Foreign  Securities of many non-U.S.
                                 companies  may be less  liquid and their  prices more  volatile  than
                                 securities of comparable U.S. companies.  Foreign stock exchanges and
                                 brokers are generally  subject to less  governmental  supervision and
                                 regulation  than U.S.  exchanges  and  brokers,  and  commissions  on
                                 foreign  stock   exchanges  are  generally   higher  than  negotiated
                                 commissions in the United States.  Foreign  accounting,  auditing and
                                 financial reporting  standards differ from U.S.  standards,  and less
                                 information   may  be  available  than  to  investors   investing  in
                                 securities  of U.S.  companies.  In  addition,  with  respect to some
                                 foreign  countries,  there  is the  possibility  of  nationalization,
                                 expropriation  or confiscatory  taxation.  Income earned in a foreign
                                 nation may be subject to  taxation  (including  withholding  taxes on
                                 interest and  dividends),  or other taxes may be imposed with respect
                                 to investments in Foreign  Securities.  Other risks  associated  with
                                 investments in Foreign Securities include  limitations on the removal
                                 of securities,  property or other assets of the Fund, difficulties in
                                 pursing  legal  remedies and obtaining  judgments in foreign  courts,
                                 political or social  instability  and  diplomatic  developments  that
                                 could adversely affect the Fund's investments in companies located in
                                 foreign countries.

                                 CURRENCY RISK. The Fund may receive a portion of its income and gains
                                 in currencies  other than U.S.  dollars,  although the Fund will make
                                 dividends and other distributions in U.S. dollars. A reduction in the
                                 value of such foreign currencies relative to the U.S. dollar prior to
                                 conversion into U.S.  dollars would  adversely  affect the Fund's NAV
                                 and  net  investment   income  and  capital  gains,  if  any,  to  be
                                 distributed to shareholders  of the Fund. See "Risk  Factors-Currency
                                 Risk."

                                 ILLIQUID  INVESTMENTS.  The Fund may  invest  up to 25% of its  total
                                 assets  in  securities  for  which  there  is  no  readily  available
                                 secondary  market.   Therefore,  the  Fund's  ability  to  sell  such
                                 securities  at a fair price may be impaired or delayed.  In addition,
                                 these securities may exhibit greater price volatility than securities
                                 for which a secondary  market exists.  Since its inception,  the Fund
                                 has consistently  made such investments.  See "Risk  Factors-Illiquid
                                 Investments."

                                 JUNK BONDS AND UNRATED DEBT SECURITIES. The Fund may invest up to 10%
                                 of its  total  assets,  in the  aggregate,  in  non-convertible  debt
                                 securities of Health Science Companies and related  companies.  These
                                 securities  and  other  investments  in such  companies  may  include
                                 securities that have been rated as low as C in the rating  categories
                                 established  by  Standard  & Poor's,  a division  of The  McGraw-Hill
                                 Companies, Inc. ("Standard & Poor's"), and Moody's Investors Service,
                                 Inc.  ("Moody's")  or may be  unrated  if deemed to be of  comparable
                                 credit quality by the Investment Manager. These securities, which are
                                 commonly  referred to as "junk bonds," are regarded,  on balance,  as
                                 

                                                  8
<PAGE>
                                 predominantly  speculative  in terms of the  ability of the issuer to
                                 pay interest or repay  principal in accordance  with the terms of the
                                 obligation and  accordingly  involve more credit risk than securities
                                 rated in the  higher  rating  categories.  Such debt  securities  are
                                 dependent upon favorable business,  financial or economic conditions,
                                 may be  subordinated  to senior  debt and can be  regarded  as having
                                 extremely  poor  prospects  of ever  attaining  any  real  investment
                                 standing.  The prices of these securities are generally more volatile
                                 than  the  prices  of  higher  rated  debt   securities.   See  "Risk
                                 Factors--Junk Bonds and Unrated Debt Securities." Such securities may
                                 be illiquid. See "Risk Factors--Illiquid Investments."

                                 SPECIAL  INVESTMENT  PRACTICES.  The Fund may make short sales, which
                                 are  transactions  in which the Fund sells a security it does not own
                                 in  anticipation  of an expected  decline in the market value of that
                                 security.  However,  the Fund  will  incur a loss if the price of the
                                 security increases between the date of the short sale and the date on
                                 which the Fund  purchases  the security to close its short  position.
                                 See   "Investment   Objective   and   Policies--Special    Investment
                                 Practices--Short Sales."

                                 The Fund may also  engage  in  certain  currency  and  other  hedging
                                 transactions,  purchase  securities  on a  when-issued  or a  delayed
                                 delivery basis, enter into repurchase agreements,  lend its portfolio
                                 securities  and borrow money to  repurchase or make tender offers for
                                 its Shares or for  temporary  purposes.  These  transactions  involve
                                 certain risks and may result in losses to the Fund.  See  "Investment
                                 Objective and Policies--Special  Investment  Practices,"  "Investment
                                 Restrictions,"    and    "Description   of   Shares   of   Beneficial
                                 Interest--Tender Offer or Repurchase of Shares."

                                 NET ASSET VALUE DISCOUNT.  Shares of closed-end  investment companies
                                 frequently  trade at a discount from their NAV:  (that is, the market
                                 price per share is less than the value per share of the net  assets).
                                 This  characteristic  is a risk  separate and distinct  from the risk
                                 that the  Fund's  NAV will  decrease  as a result  of its  investment
                                 activities  and may be greater for investors  expecting to sell their
                                 Shares  relatively soon after completion of this Offering.  It should
                                 be  noted,   however,  that  shares  of  some  closed-end  management
                                 investment  companies  (commonly referred to as "closed-end  funds"),
                                 including  the Fund,  have traded at premiums to NAV. The Fund cannot
                                 predict  whether  the Shares will trade at,  above or below NAV.  See
                                 "Risk Factors--Net Asset Value Discount."

                                 ANTI-TAKEOVER  PROVISIONS  OF THE  FUND'S  DECLARATION  OF TRUST  AND
                                 BY-LAWS.  The Fund's  Declaration  of Trust as amended on December 5,
                                 1991  ("Declaration of Trust") and By-Laws and any amendments thereto
                                 ("By-Laws")   (together,   the  "Charter   Documents")  have  certain
                                 "anti-takeover" provisions that could have the effect of limiting (i)
                                 

                                                  9
<PAGE>
                                 the ability of other  entities  or persons to acquire  control of the
                                 Fund, (ii) the Fund's freedom to engage in certain transactions,  and
                                 (iii) the  ability of the Board or the Fund's  shareholders  to amend
                                 the Charter Documents or to effect changes in the Fund's  management.
                                 Such provisions also may dissuade third parties from making offers to
                                 purchase Shares at a premium over market price.  See  "Description of
                                 Shares of Beneficial Interest-Certain Anti-Takeover Provisions of the
                                 Declaration of Trust and By-Laws."

                                 YEAR 2000.  INVESCO  has  committed  substantial  resources  and made
                                 significant  progress  toward  making sure its computer  systems will
                                 continue to operate  smoothly  through the year 2000 and expects that
                                 its business  partners also will be prepared for the year 2000. While
                                 INVESCO does not anticipate interruptions in its business,  investors
                                 should be aware of the possible risks. As is widely known, there is a
                                 chance that some computer systems may not function after December 31,
                                 1999  because  they  fail to  recognize  dates in the  year  2000 and
                                 beyond. If a system at INVESCO or one of its business partners should
                                 fail, it could  adversely  affect the Fund. In addition,  the markets
                                 for,  or values of,  securities  in which the Fund  invests  could be
                                 affected   by  computer  failures on  or after January 1, 2000. While
                                 INVESCO  cannot  make  assurances  that  this  will  not  happen,  it
                                 continues  to  thoroughly  analyze  the  securities  it  invests  in,
                                 including the possible effects of the year 2000 computer  problems on
                                 a company or the market the security trades in. See "Risk Factors and
                                 Special Considerations - Year 2000."

                                 You should  carefully  consider  your ability to assume the foregoing
                                 risks before  making an  investment  in the Fund.  An  investment  in
                                 Shares is not appropriate for all investors.


                                                  10
</TABLE>


<PAGE>
                                    FEE TABLE

The  following  tables are  intended to assist  investors in  understanding  the
various costs and expenses that an investor in this Offering will bear, directly
or indirectly.

SHAREHOLDER TRANSACTION EXPENSES
Sales Load (as a percentage of Subscription Price)(1)..................[3.75%]
Dividend Reinvestment and Cash Purchase Plan Fees(2)......................None

ANNUAL FUND OPERATING EXPENSES (AS A PERCENTAGE OF NET ASSETS ATTRIBUTABLE TO
SHARES)(3)
Management and Administrative Fees(4)................................... 0.99%
Interest Payments on Borrowed Funds ....................................  None
Other Expenses.......................................................... 0.22%
Total Annual Fund Expenses.............................................. 1.21%

- ---------------

(1) The Fund has agreed to pay the Dealer  Manager a Dealer  Manager Fee for its
financial  advisory and  marketing  services  equal to [1.25%] of the  aggregate
Subscription Price for each Share issued pursuant to the Offer, and the Fund has
also agreed to pay  broker-dealers,  including the Dealer Manager,  Solicitation
Fees for their solicitation efforts of 2.50% of the Subscription Price per Share
for each Share issued pursuant to the Offer.  Solicitation  Fees will be paid to
the  broker-dealer  designated  on the  applicable  portion of the  Subscription
Certificate or, in the absence of any such  designation,  to the Dealer Manager.
Other offering expenses incurred by the Fund are estimated at [$       ],  which
includes  up to  [$       ] that may be paid to the  Dealer Manager  as  partial
reimbursement  for its expenses  relating to the Offer.  These fees and expenses
will be  borne by the Fund and  indirectly  by all of the  Fund's  shareholders,
including those shareholders who do not exercise their Rights.

(2) The Fund,  its  transfer  agent,  and the dividend  dispensing  agent or its
delegate impose no fee for  participation in the Dividend  Reinvestment and Cash
Purchase Plan  ("Reinvestment  Plan"). Each participant in the Reinvestment Plan
will pay a PRO RATA share of brokerage  commissions  incurred in connection with
open-market purchases of Shares under the Reinvestment Plan.

(3) Amounts are estimated for the Fund's current fiscal year after giving effect
to  anticipated  net proceeds of the Offer,  assuming that all of the Rights are
exercised  and  that  the Fund  incurs  the  estimated  [$       ]  of  offering
expenses.

(4)  The  Fund  pays  the  Investment  Manager  an  annualized  management  fee,
calculated  daily  and  paid  monthly,  in the amount of 1.00% on the first $500
million of ending  daily  net  assets  and 0.90% on ending  daily  net assets in
excess of $500 million.  The Fund also pays the Investment Manager an annualized
administrative  fee,  calculated  and paid  monthly,  in the  amount of 0.10% of
ending daily net assets.


                                       11
<PAGE>


EXAMPLE

The  following  Example  demonstrates  the  projected  dollar  amount  of  total
cumulative expense that would be incurred over various periods with respect to a
hypothetical  investment  in the Fund through this  Offering.  These amounts are
based upon payment by the Fund of operating  expenses at the levels set forth in
the above table.

An investor would directly or    1 Year      3 Years      5 Years      10 Years
indirectly pay the following     ------      -------      -------      --------
expenses on a $1,000         
investment in the Fund,      
assuming a 5% annual return  
throughout the relevant      
period and reinvestment of       $12.30       $38.40       $66.50      $146.60
all dividends and other      
distributions at NAV:        

THE  FOREGOING  FEE TABLE AND  EXAMPLE  ARE  INTENDED  TO  ASSIST  INVESTORS  IN
UNDERSTANDING  THE COSTS AND  EXPENSES  THAT AN  INVESTOR  IN THE FUND WILL BEAR
DIRECTLY OR INDIRECTLY.

The Example set forth above  assumes  reinvestment  of all  dividends  and other
distributions  at NAV,  payment of a [3.75%]  sales  load and an annual  expense
ratio of 1.21%. The table above and the assumption in the Example of a 5% annual
return are required by SEC regulations  applicable to all management  investment
companies. In addition,  while the Example assumes reinvestment of all dividends
and  other  distributions  at NAV,  participants  in the  Reinvestment  Plan may
receive Shares  purchased or issued at a price or value  different from NAV. See
"Dividends  and Other  Distributions;  Dividend  Reinvestment  and Cash Purchase
Plan."

THE EXAMPLE  SHOULD NOT BE CONSIDERED A REPRESENTATION  OF FUTURE EXPENSES,  AND
THE FUND'S ACTUAL EXPENSES MAY BE MORE OR LESS THAN THOSE SHOWN.


                                       12
<PAGE>

                             FINANCIAL HIGHLIGHTS

The table below sets forth certain specified information for a Share outstanding
throughout  each period  presented.  Except for the period from November 1, 1998
through April 30, 1999, the financial  highlights for each period presented have
been audited by PricewaterhouseCoopers  LLP, the Fund's independent accountants,
whose  unqualified  report is  included  in the Fund's  October  31, 1998 Annual
Report and is  incorporated  by reference in the SAI. The  financial  highlights
should be read in  conjunction  with the financial  statements and notes thereto
included  in the Fund's  October  31, 1998  Annual  Report,  which is  available
without charge by calling the Fund at  1-800-528-8765  or by contacting the Fund
at 7800 E. Union Avenue, Suite 800, Denver, Colorado 80237.

                                   

                             Six Month Period          
                           Ended April 30, 1999      Year Ended October 31
                           --------------------      ---------------------
                                  (unaudited)      1998(e)       1997      1996
                                  -----------      ----          ----      ----
PER SHARE DATA
Net Asset Value - Beginning of         [$X.XXX]   $21.250    $22.230   $18.506
  Period
- --------------------------------------------------------------------------------
INCOME FROM INVESTMENT
OPERATIONS
Net Investment Income (Loss)           [$X.XXX]     0.000    (0.071)   (0.097)
Net Gains or (Losses) on
Securities (Both Realized and          [$X.XXX]     3.755      3.564     3.821
Unrealized)
- --------------------------------------------------------------------------------
TOTAL FROM INVESTMENT
OPERATIONS                             [$X.XXX]     $3.755    $3.493    $3.724
- --------------------------------------------------------------------------------
LESS DISTRIBUTIONS
Dividends from Net Investment          [$X.XXX]     0.000      0.000     0.000
Income
Distributions from Net Capital         [$X.XXX]     3.925      4.473     0.000
Gains
- --------------------------------------------------------------------------------
TOTAL DISTRIBUTIONS                    [$X.XXX]    $3.925     $4.473    $0.000
- --------------------------------------------------------------------------------
Net Asset Value - End of Period        [$X.XXX]   $21.080    $21.250   $22.230
- --------------------------------------------------------------------------------
Share Market Price, End of                         $19.500    $17.313   $17.000
Period
TOTAL INVESTMENT RETURN(a)           [X.XX%](b)     40.29%     32.98%    15.25%
RATIOS
Net Assets - End of Period           [$XXX,XXX]  $586,263   $526,215  $455,842
($000 Omitted)
Ratio of Expenses to Average     [X.XX%](c), (d)  1.21%(c)   1.22%(c)     1.21%
Net Assets
Ratio of Net Investment Income
(Loss) to Average Net Assets          [X.XX%](d)   (0.17%)    (0.15%)   (0.44%)
Portfolio Turnover Rate               [X.XX%](b)       87%       145%       91%

                                                   FOOTNOTES ON FOLLOWING PAGE



                                       13
<PAGE>

                                             Year Ended October 31
                                             ---------------------
                                                                   Period Ended
                                        1995     1994    1993   October 31, 1992
                                        ----     ----    ----   ----------------
                                                                            
PER SHARE DATA
Net Asset Value - Beginning of       $12.378  $12.121   $12.643         $13.950
Period
- --------------------------------------------------------------------------------
INCOME FROM INVESTMENT
OPERATIONS
Net Investment Income (Loss)         (0.107)  (0.085)     0.205           0.071
Net Gains or (Losses) on                                
Securities (Both Realized and          6.235   0.542     (0.652)         (1.345)
Unrealized)
- --------------------------------------------------------------------------------
TOTAL FROM INVESTMENT                                  
OPERATIONS                            $6.128  $0.457    ($0.447)       ($01.274)
- --------------------------------------------------------------------------------
LESS DISTRIBUTIONS
Dividends from Net Investment          0.000   0.200     0.075           0.000
Income
Distributions from Net Capital         0.000   0.000     0.000           0.033
Gains
- --------------------------------------------------------------------------------
TOTAL DISTRIBUTIONS                   $0.000  $0.200    $0.075          $0.033
- --------------------------------------------------------------------------------
Net Asset Value - End of Period      $18.506  $12.378   $12.121         $12.643
- --------------------------------------------------------------------------------
Share Price, End of Period           $14.750  $10.000   $11.500         $11.500

TOTAL INVESTMENT RETURN(a)             47.50% (11.49%)    0.67%    (17.568%)(b)

RATIOS

Net Assets - End of Period          $379,503 $253,834  $248,564        $259,279
($000 Omitted)

Ratio of Expenses to Average           1.33%    1.41%     1.39%        1.35%(d)
Net Assets 

Ratio of Net Investment Income                       
(Loss) to Average Net Assets         (0.72%)  (0.70%)     1.74%        0.72%(d)

Portfolio Turnover Rate                 105%     121%      226%         215%(b)


(a) Total investment  return is calculated  assuming a purchase of Shares at the
current  market price on the first day and a sale at the current market price on
the last day of each period reported. Dividends and other distributions, if any,
are  assumed,  for  purposes of this  calculation,  to be  reinvested  at prices
obtained under the Reinvestment  Plan. Total investment  return does not reflect
sales charges or brokerage commissions.

(b)  Based  on  operations  for  the  period  shown  and,  accordingly,  are not
representative of a full year. 

(c)  Ratio is  based on total expenses of the Fund, which are before any expense
offset arrangements.

(d) Annualized.  

(e) INVESCO has served as the Fund's investment  adviser since February 4, 1998.
Prior to February  4, 1998,  ITC,  then a wholly  owned  subsidiary  of INVESCO,
served as the Fund's investment adviser.

                                       14
<PAGE>

PORTFOLIO CHARACTERISTICS AND COMPOSITION

The  following  tables  set  forth  certain  information  with  respect  to  the
characteristics  and the  composition of the Fund's  investment  portfolio as of
April 30, 1999. Portfolio composition and weightings are subject to change.

PORTFOLIO COMPOSITION--TOP TEN HOLDINGS
DESCRIPTION                                  VALUE          % OF NET ASSETS

                                      $                                   %








Total                                 $                                   %
COMPOSITION OF HOLDINGS IS SUBJECT
TO CHANGE.

PORTFOLIO COMPOSITION - DESCRIPTION OF HOLDINGS

COMMON STOCKS & WARRANTS               %
BIOTECHNOLOGY                          %
HEALTH CARE DELIVERY                   %
MEDICAL DEVICES & SUPPLIES             %
PHARMACEUTICALS                        %

PREFERRED STOCKS                       %
BIOTECHNOLOGY                          %
HEALTH CARE DELIVERY                   %
MEDICAL DEVICES & SUPPLIES             %

FIXED INCOME SECURITIES                %
BIOTECHNOLOGY                          %
HEALTH CARE DELIVERY                   %

OTHER SECURITIES                       %
MEDICAL DEVICES & SUPPLIES             %

SHORT-TERM INVESTMENTS                 %
CORPORATE BONDS                        %
BIOTECHNOLOGY                          %

REPURCHASE AGREEMENTS                  %
TOTAL INVESTMENT SECURITIES AT VALUE   %
COMPOSITION OF HOLDINGS IS SUBJECT TO
CHANGE


                                       15
<PAGE>

                        CAPITALIZATION AT APRIL 30, 1999


                                      SHARES OUTSTANDING
                                      EXCLUSIVE OF AMOUNT   AMOUNT HELD BY FUND
                        AMOUNT       HELD BY FUND FOR ITS   FOR ITS OWN ACCOUNT
   TITLE OF CLASS      AUTHORIZED         OWN ACCOUNT             ACCOUNT
   --------------      ----------         -----------             -------

Common Shares of
Beneficial
Interest, par value    Unlimited         [30,156,115]               -0-
$0.01

                     INFORMATION REGARDING SENIOR SECURITIES

Subject to its investment restrictions,  the Fund has the right to use financial
leverage  to finance  the  repurchase  of or tender  offers for Shares or to pay
dividends and  other  distributions  and may borrow for temporary purposes.  The
Fund  expects it may use  financial  leverage  from time to time in the  future.
Currently,  however,  the  Fund has not  determined  the  timing  or  amount  of
financial leverage that it would utilize.

                     TRADING AND NET ASSET VALUE INFORMATION

In the past, the Shares have generally  traded at a discount in relation to NAV.
Shares of closed-end investment companies, such as the Fund, frequently trade at
a discount from NAV. See "Risk Factors and Special Considerations."

The Shares are listed and traded on the NYSE under the ticker  symbol "GHS." The
Rights will not be admitted for trading on the NYSE or any other stock exchange.
The  average  weekly  trading  volume of the Shares on the NYSE  during the year
ended  December 31, 1998 was 70,680  Shares.  The following  table shows for the
fiscal  quarters for the two most recent  fiscal  years and the fiscal  quarters
during the current fiscal year: (1) the high and low sale price of the Shares on
the NYSE  during  the  quarter;  (2) the high and low NAV per Share  during  the
quarter; and (3) the high and low premium or discount to NAV at which the Shares
were trading during the quarter.

                                                          PREMIUM/(DISCOUNT) TO
     For the          PRICE(1)       NET ASSET VALUE(2)   TO NET ASSET VALUE(3)
  Quarter Ended   High     Low        High      Low       High        Low
- --------------------------------------------------------------------------------
January 31, 1997  $18.8750 $14.3750   $22.87    $18.03   (23.677%)   (17.360%)
April 30, 1997    $17.3750 $14.5000   $20.36    $17.94   (19.666%)   (14.330%)
July 31, 1997     $18.1875 $14.8750   $21.87    $18.48   (21.411%)   (14.907%)
October 31, 1997  $18.6250 $16.3750   $22.87    $20.39   (21.053%)   (16.027%)
January 31, 1998  $18.750  $15.9375   $21.99    $17.88   (18.137%)   (7.771%)
April 30, 1998    $19.8750 $18.0000   $21.82    $20.09   (13.338%)   (6.064%)
July 31, 1998     $21.0625 $18.5000   $22.74    $20.15   (10.755%)   (5.938%)
October 31, 1998  $19.5000 $15.7500   $21.35    $18.74   (16.578%)   (7.495%)
January 31, 1999  $20.0625 $17.6875   $21.68    $18.77   (9.199%)    (2.927%)
April 30, 1999    $        $          $         $        (%)         (%)
- --------------------------------------------------------------------------------
(1) NYSE
(2) INVESCO
(3) INVESCO

                                       16
<PAGE>


Immediately  prior [       ] the  Fund's  announcement of the Offer on [      ],
1999, and on [     ],  1999,  the  last  reported  sale  price  of  [      ]   a
Share on the NYSE was  [$     ] and $_______, respectively.  The  Fund's NAV per
Share on [      ], 1999 and on [      ], was $_______ and $______, respectively.
See "Net Asset Value" in the SAI.

                                    THE FUND

The Fund is a diversified  closed-end  investment  management company registered
with the SEC. It is actively managed to seek capital appreciation.  Employing an
aggressive investment philosophy,  the Fund normally invests at least 80% of its
total  assets in equity  securities  of Health  Science  Companies.  There is no
guarantee  that the Fund will meet its  investment  objective.  See  "Investment
Objective and Policies" and "Risk Factors and Special Considerations."

The Fund's objective is to seek capital appreciation by investing  substantially
all of its assets in equity and related  securities  of U.S. and foreign  Health
Science Companies.  It seeks to achieve its objective by investing its assets in
a  broad  range  of  health  care  related  equities,   such  as  market-leading
pharmaceutical  companies,  medical  devices  manufacturers  and suppliers,  and
various  private  placement  investments.  The Fund may focus its investments in
these  sectors.  For  example,  at this  time  approximately  60% of the  Fund's
portfolio  is  invested  in stocks  of  pharmaceutical  companies.  The Fund may
purchase and sell  options on equities.  For  information  regarding  the Fund's
portfolio  characteristics  and composition as of April 30, 1999, see "Portfolio
Characteristics and Composition."

Demographics  continue to indicate  growth in the health sciences  industry,  as
individuals  live longer  lives,  on average,  and  therefore  comprise a larger
proportion of the mature population today than ever before. People over 65 years
of age consume the  largest  proportion  of health  sciences  products,  such as
pharmaceuticals.  In the United  States,  as persons  born in the late 1940's to
early 1950's,  known in the United States as the "baby boomers," advance in age,
they are likely to consume  increasing  amounts of chronic  care drugs and other
health science products.

The health sciences industry has increased research and development expenditures
to  develop  new  and  better   products.   Because  the  U.S.   Food  and  Drug
Administration in the 1990's has continued to expedite approval of new products,
newly-developed  health  products  reach  the  market  at an  accelerated  pace.
Simultaneously,  many Health Science  Companies face  relatively low exposure to
patent litigation.  With more new products, a shorter  product-to-market period,
and reduced patent  litigation  risk, the health sciences  industry  anticipates
increased revenues and profitability.

The introduction of new technologies in the medical  equipment and biotechnology
sectors  has  significantly  contributed  to growth in the  hospital  supply and
medical  device   industries.   New  technologies  have  enabled  the  increased
development of sophisticated devices and procedures. In addition,  biotechnology
companies  are  offering  an  increasing  number  of  new  products.  Trends  in
demographics  and  potentially   accelerated  drug  approvals  could  result  in
significant  growth  in  the  pharmaceutical  sector   as  well.  Moreover,  the
favorable  outlook  for the  United  States  economy  could  benefit  the health
sciences   industry  through  more  readily  available  capital  for  developing
proprietary  products  and by the  increasing  affluence  of  consumers of those
products.

Closed-end funds, such as the Fund, differ from open-end  management  investment
companies  (commonly  referred to as "mutual  funds") in that  closed-end  funds
generally  list their  shares for trading on a  securities  exchange  and do not
redeem  their shares at the option of the  shareholder.  By  comparison,  mutual
funds issue  securities  redeemable at NAV at the option of the  shareholder and


                                       17
<PAGE>


typically  engage in a  continuous  offering of their  shares.  Mutual funds are
subject to continuous asset in-flows and out-flows that can complicate portfolio
management,  whereas  closed-end funds generally can stay more fully invested in
securities  consistent with their respective investment objectives and policies.
In addition,  in comparison  to open-end  funds,  closed-end  funds have greater
flexibility in the  employment of financial  leverage and in the ability to make
certain  types of  investments,  such as  investments  in  illiquid  securities.
However,  shares of closed-end  funds  frequently trade at a discount from their
NAV.

The Fund was organized as a business trust under the laws of the Commonwealth of
Massachusetts  on November  18, 1991 and has  registered  with the SEC under the
1940 Act. The Fund commenced investment operations on January 24, 1992 under the
name Global  Health  Sciences  Fund.  On July 1, 1997,  the name of the Fund was
changed to INVESCO Global Health Sciences Fund. The Fund's  principal  office is
located at 7800 E. Union Avenue, Suite 800, Denver, Colorado 80237. The Fund has
contracted  with  INVESCO  to serve as its  investment  adviser.  INVESCO  is an
investment management firm registered with the SEC under the Investment Advisers
Act of 1940, as amended.

                                    THE OFFER

PURPOSE OF THE OFFER

As discussed below, the Board of Trustees has determined that it would be in the
best  interests of the Fund and its  shareholders  to make the Offer.  The Board
considered the proposal for the Offer at several  meetings,  including a meeting
at which the independent  Trustees (as defined under the 1940 Act) ("Independent
Trustees") met with counsel and without management present to discuss the Offer.
The Board,  including all of the Independent Trustees,  unanimously approved the
Offer.  In its  deliberations,  the Board  considered  a number  of  issues  and
factors,  including the potential impact of the Offer on current  exercising and
non-exercising  shareholders;  the  potential  impact of the Offer on the Fund's
NAV, Share price,  and trading  activity;  the potential  dilutive impact of the
Offer  on  the  Fund  and  its   shareholders   (in  particular   non-exercising
shareholders); the revenue impact of the Offer on the Investment Manager and its
affiliates; the value and quality of the services expected to be provided by the
Dealer  Manager in light of the  relationship  between  the Dealer  Manager  and
existing  shareholders;  the Dealer Manager's familiarity with the Fund and with
the  Investment  Manager;  and the terms of the Offer  compared  to the terms of
similar  offers  conducted  by other  closed-end  funds.  The Board of  Trustees
concluded that increasing the assets of the Fund would be beneficial to the Fund
and  its  shareholders.  However,  there  can be no  assurance  that  any of the
anticipated  benefits  discussed in this Prospectus will be realized as a result
of the Offer.

The Board  determined that it would be in the best interests of the Fund and its
existing  shareholders  to  increase  the  assets  of  the  Fund  available  for
investment,  thereby allowing the Fund to more fully take advantage of available
investment  opportunities  consistent with its investment objective. In reaching
its decision,  the Board of Trustees was advised by the Investment  Manager that
the  availability  of new  assets  would  give  the Fund  additional  investment
flexibility,  as well as an  enhanced  ability  to take  advantage  of what  the
Investment Manager believes to be timely investment opportunities.  It was noted
that,  to take  advantage  of these  opportunities  without an  infusion  of new
capital,  the Fund would be required to sell current portfolio positions that it
desired to retain,  which could cause the  realization  of  significant  capital
gains by the Fund and its  shareholders.  The  Investment  Manager  provided its
views to the  effect  that  while  the Fund is  permitted  to  borrow  money for
investment purposes under current market conditions,  it would not be prudent to
do so, because raising  additional  money through the Offer would be less costly
than  borrowing  the same  amount of money.  With an  increased  asset base as a


                                       18
<PAGE>


result of the Offer,  the Investment  Manager believes the Fund would be able to
invest in a larger  universe  of  securities  that it  believes  would  have the
benefits described below.

The  Board  of  Trustees  considered  that the Fund  could  potentially  achieve
additional  economies  of scale  as a result  of an  increase  in total  assets,
resulting  in a nominal  decrease  in the Fund's  operating  expense  ratio.  In
addition,  the  Fund  and  the  Investment  Manager  recently  agreed  to  add a
breakpoint to the investment  management  agreement for assets in excess of $500
million. At the Fund's current asset size,  substantially all of the proceeds of
the Offer  would be managed at this  lower fee,  which  could have the effect of
lowering the Fund's overall  expense ratio.  In addition,  the Board of Trustees
considered  that the  Offering  could  ultimately  result in a larger  number of
shareholders  and  daily  trading  volume  and  therefore  could  result  in  an
improvement  in the liquidity of the trading  market for the Shares on the NYSE,
where the Shares are listed and traded. The Board of Trustees also believes that
a larger number of outstanding  Shares and a larger number of beneficial  owners
of Shares could increase the level of market interest in the Fund.

In addition,  the Board of Trustees  considered that the Offer affords  existing
shareholders the opportunity to purchase  additional Shares at a price that will
be  below  the  lower of  market  value  or  NAV.  The  Board of  Trustees  also
considered  the expenses of the Offer and its  dilutive  effect,  including  the
effect on non-exercising shareholders.

The Board of Trustees  noted that the  Investment  Manager will benefit from the
Offer  because  its fees for  investment  management  services  are based on the
average daily net assets of the Fund. It is not possible to state  precisely the
amount of  additional  compensation  the  Investment  Manager  will receive as a
result of the Offer,  because it is not known how many Rights will be  exercised
and because the proceeds of the Offer will be invested in  additional  portfolio
securities that may fluctuate in value. However, if all the Rights are exercised
in full,  including the additional [     ] Shares by which the Fund may increase
the Offer,  based on the Estimated  Subscription Price of $_____, the Investment
Manager would receive  additional  fees for  investment  management  services of
approximately  $_____ per annum and additional fees for administrative  services
of  approximately  $_____ per annum as a result of the  increase in assets under
management.

In  determining  that the  Offer is in the  best  interests  of the Fund and its
shareholders,  the Board of Trustees  retained the Dealer Manager to provide the
Fund with  financial  advisory  and  marketing  services  relating to the Offer,
including  the  structure,  timing and terms of the Offer.  In  addition  to the
foregoing,  the  Board of  Trustees  considered,  among  other  things,  using a
variable pricing versus fixed pricing  mechanism,  the benefits and drawbacks of
conducting a non-transferable  versus a transferable rights offering, the effect
on the Fund if the Offer is  undersubscribed  and the  experience  of the Dealer
Manager in conducting rights offerings. The Investment Manager advised the Board
that the  non-transferability  of the Rights may limit,  but will not eliminate,
the activity of arbitrageurs.

The Fund and the  Investment  Manager  have  received an order and an  amendment
thereto  (collectively  "Order") from the SEC  permitting the Fund to make up to
four  distributions of net long-term  capital gains in any taxable year, so long
as the Fund  maintains in effect a  distribution  policy  calling for  quarterly
distributions  of a fixed  percentage  of its NAV (the  "Quarterly  Distribution
Policy").  The Fund and the  Investment  Manager  agreed that, as a condition to
obtaining the Order,  the relief  granted by the Order shall  terminate upon the
effective date of a registration  statement under the Securities Act of 1933 for
any  future  public  offering  by the  Fund of  Shares.  The  Order  will not be
terminated,  however,  for (among other specified  reasons) a rights offering to
shareholders  of the Fund if (a) Shares will be issued only within the  six-week
period immediately  following the record date of a quarterly  dividend,  (b) the




                                       19
<PAGE>


prospectus for such rights offering makes it clear that shareholders  exercising
the Rights will not be entitled to receive such  dividend,  and (c) the Fund has
not engaged in more than one rights offering during any given calendar year.

The Fund may,  in the future and at its  discretion,  choose to make  additional
rights offerings of Shares from time to time for a number of Shares and on terms
that may or may not be similar to this Offer.  Any such future  offering will be
made in accordance with the 1940 Act.

TERMS OF THE OFFER

The  Fund  is  issuing  to  Record  Date  Shareholders  non-transferable  Rights
entitling the holders  thereof to subscribe for an aggregate of [      ] Shares,
par value $0.01 per Share ([        ] Shares if the Fund increases the number of
Shares available by up to 25% in connection with the Over-Subscription Privilege
described  below).  Each Record Date  Shareholder  is being issued one Right for
every [X#] Shares owned on the Record Date (1-for-[X#]).  The Rights entitle the
holders  thereof  to  subscribe  for one Share  for  every  one Right  held (the
"Primary Subscription"). Fractional Shares will not be issued on the exercise of
fractional  Rights.  Accordingly,   Shares  may  be  purchased  in  the  Primary
Subscription  only pursuant to the exercise of whole Rights.  For example,  if a
Record Date  Shareholder  owns 102 Shares,  that  shareholder  will receive [X#]
Rights,  but may only  exercise  [XXX#]  Rights for the purchase of [XX] Shares,
with  the  unexercised   fractional  Rights  expiring.   However,   Record  Date
Shareholders  holding  fewer than [X#]  Shares  will be entitled to one Right to
subscribe  for one Share  pursuant  to the  Primary  Subscription.  Record  Date
Shareholders  may request  additional  Shares pursuant to the  Over-Subscription
Privilege.

Rights may be  exercised  at any time  during  the  subscription  period,  which
commences  on [      ], 1999  and  ends  at 5:00  P.M.,  Eastern  time,  on  the
Expiration Date (the "Subscription  Period"). See "Expiration of the Offer." The
Rights are evidenced by Subscription  Certificates that will be mailed to Record
Date Shareholders, except as discussed below under "Foreign Restrictions."

Shares not subscribed for in the Primary  Subscription will be offered, by means
of the Over-Subscription  Privilege,  to those Record Date Shareholders who have
exercised all Rights issued to them and who wish to acquire more than the number
of whole Shares they are entitled to purchase  pursuant to the exercise of their
Rights. Shares acquired pursuant to the Over-Subscription  Privilege are subject
to allotment and may be subject to increase, as more fully discussed below under
"Over-Subscription Privilege." For purposes of determining the maximum number of
Shares a Record Date Shareholder may acquire pursuant to the Offer,  Record Date
Shareholders whose Shares are held of record by Cede & Co. ("Cede"),  as nominee
for The Depository Trust Company ("DTC"), or by any other depository or nominee,
will be deemed to be the  holders of the Rights  that are issued to Cede or such
other depository or nominee on their behalf.

Because  fractional  Shares  will not be issued,  Record Date  Shareholders  who
receive or have  remaining  fractional  Rights will be unable to  exercise  such
remaining Rights for the purchase of fractional  Shares and will not be entitled
to receive any cash in lieu thereof.  Such shareholders  may,  however,  request
additional  Shares  pursuant to the  Over-Subscription  Privilege.

The  Board of  Trustees,  in  consultation  with  the  Investment  Manager,  has
implemented a Quarterly Distribution Policy, which entails quarterly payments of
dividends in an amount equal to 2.5% of the Fund's NAV. The first dividend to be
paid on Shares  acquired on  exercise of the Rights will be the first  quarterly
dividend,  the record date for which  occurs  after the  issuance of the Shares.


                                       20
<PAGE>



Assuming the Subscription Period is not extended,  it is expected that the first
dividend received by shareholders  acquiring Shares in the Offer will be paid on
[      , 1999].

There is no minimum  number of Rights  that must be  exercised  in order for the
Offer to close.

The record date for the Fund's most recent quarterly  dividend was May 11, 1999.
Record Date  Shareholders  will not be entitled to receive  that  dividend  with
respect to those Shares that they receive pursuant to the Offer.

OVER-SUBSCRIPTION PRIVILEGE

If Record Date  Shareholders  do not exercise all the Rights issued to them, any
Shares  represented  by  unexercised  Rights  will be  offered  by  means of the
Over-Subscription  Privilege to the Record Date  Shareholders who have exercised
all the Rights issued to them and who wish to subscribe for  additional  Shares.
Only Record Date  Shareholders  who exercise  all the Rights  issued to them may
indicate on the  Subscription  Certificate,  which they or their nominees submit
with respect to the exercise of the Rights issued to them,  how many Shares they
desire to purchase pursuant to the  Over-Subscription  Privilege.  If sufficient
Shares   remain   after   completion   of   the   Primary   Subscription,    all
over-subscription requests will be honored in full. If sufficient Shares are not
available   after   completion  of  the  Primary   Subscription   to  honor  all
over-subscription  requests,  the Fund may,  at the  discretion  of the Board of
Trustees,  issue up to an additional 25% of the Shares available pursuant to the
Offer  (up  to  an   additional  [        ] Shares)   in  order  to  cover  such
over-subscription   requests.   Regardless  of  whether  the  Fund  issues  such
additional  Shares,  and to the  extent  Shares are not  available  to honor all
over-subscription  requests,  the available Shares will be allocated among those
who over-subscribe so that the number of Shares issued to such shareholders will
generally be in proportion to the number of Shares owned by such shareholders on
the Record Date. The  allocation  process may involve a series of allocations in
order to assure that the total number of Shares available for  over-subscription
is distributed on a PRO RATA basis.

Banks, brokers, trustees and other nominee holders of Rights will be required to
certify   to  the   Subscription   Agent  (as   defined   below),   before   any
Over-Subscription  Privilege  may be exercised  with  respect to any  particular
beneficial owner, as to the aggregate number of Rights exercised pursuant to the
Primary  Subscription  and the number of Shares  subscribed  for pursuant to the
Over-Subscription  Privilege by such  beneficial  owner and that such beneficial
owner's   Primary   Subscription   was   exercised  in  full.   Nominee   Holder
Over-Subscription  Forms  and  Beneficial  Owner  Certification  Forms  will  be
distributed to banks, brokers, trustees and other nominee holders of Rights with
the Subscription Certificates.

The Fund will not offer or sell in connection with the Offer any Shares that are
not subscribed for pursuant to the Primary Subscription or the Over-Subscription
Privilege.

SUBSCRIPTION PRICE

The Subscription Price for each Share to be issued pursuant to the Offer will be
[XX%] of the lower of (1) the average of the last reported sales price per Share
on the NYSE on the  Expiration  Date and on the preceding  four Business Days or
(2) the  closing  NAV per Share on the  Expiration  Date.  For  example,  if the
average of the last reported sales price per Share on the NYSE on the Expiration
Date and on the four preceding  Business Days is $20.00, and the closing NAV per
Share on the Expiration Date is $19.00,  the Subscription Price will be [$XX.xx]
(XX% of $19.00).  If, however,  the average of the last reported sales price per
Share on the NYSE on the Expiration Date and on the four preceding Business Days



                                       21
<PAGE>


is $18.00,  and the closing NAV per Share on the Expiration Date is $19.00,  the
Subscription Price will be [$XX.xx] (XX% of $18.00).

The Fund announced the Offer on [     ], 1999. The NAV per Share at the close of
business  on [       ], 1999 (the last trading date on  which the  Fund publicly
reported its NAV per Share prior  to the  announcement) and on [         ], 1999
(the last  trading  date on which the Fund  publicly  reported its NAV per Share
prior to the date of this Prospectus) was $_____ and $_____,  respectively,  and
the last  reported  sale price per Share on the NYSE on those  dates was $______
and $_______, respectively.

NON-TRANSFERABILITY OF RIGHTS

The Rights are  non-transferable  and, therefore,  may not be purchased or sold.
The Rights  will not be listed for  trading on the NYSE or any other  securities
exchange.  However, the Shares to be issued pursuant to the Offer will be listed
for trading on the NYSE, subject to notice of issuance.

EXPIRATION OF THE OFFER

The  Offer  will  expire  at  5:00 P.M.,  Eastern time, on [     ], 1999, unless
extended  by the  Fund until 5:00 P.M.,  Eastern  time, to a date not later than
[     ], 1999.  The   Rights    will   expire   on   the   Expiration  Date  and
thereafter  may not be exercised.  Because the Offer expires and the Shares will
be priced on the same  date,  Record  Date  Shareholders  who  decide to acquire
Shares  in  the  Primary  Subscription  or  pursuant  to  the  Over-Subscription
Privilege  will not know the  Subscription  Price of the  Shares  when they make
their  decision.  Any  extension  of the Offer will be  followed  as promptly as
practicable by announcement  thereof.  Such announcement will be issued no later
than 9:00 A.M.,  Eastern time, on the next Business Day following the previously
scheduled  Expiration  Date.  Without  limiting the manner in which the Fund may
choose to make such  announcement,  the Fund will not, unless otherwise required
by law, have any obligation to publish,  advertise or otherwise  communicate any
such  announcement  other than by making a release to the Dow Jones News Service
or such other means of announcement as the Fund deems appropriate.

SUBSCRIPTION AGENT

The subscription agent is EquiServe, Inc. (the "Subscription Agent" or "EI"). EI
will receive for its administrative, processing, invoicing and other services as
Subscription  Agent,  a fee estimated to be  approximately  $[ ], which includes
reimbursement  for  all  out-of-pocket   expenses  related  to  the  Offer.  The
Subscription Agent is also the Fund's transfer agent,  dividend-paying agent and
registrar  for the Shares.  Questions  regarding the  Subscription  Certificates
should be directed to (___)___-____ [(toll free)]; shareholders may also consult
their brokers or nominees.

Completed Subscription Certificates must be sent together with proper payment of
the Subscription Price for all Shares subscribed for in the Primary Subscription
and pursuant to the  Over-Subscription  Privilege (for Record Date Shareholders)
to EI by one of the methods described below.

Alternatively,  Notice  of  Guaranteed  Delivery  may be  sent by  facsimile  to
(___)___-____  to be  received  by the  Subscription  Agent  prior to 5:00 P.M.,
Eastern  time,  on the  Expiration  Date.  Facsimiles  should  be  confirmed  by
telephone at  (___)___-____.  The Fund will accept only  properly  completed and
executed  Subscription  Certificates  actually  received at any of the addresses
listed below, prior to 5:00 P.M., Eastern time, on the Expiration Date or by the
close of business on the third



                                       22
<PAGE>


Business Day after the Expiration  Date following  timely receipt of a Notice of
Guaranteed Delivery. See "Payment for Shares" below.

 BY FIRST CLASS MAIL:     BY OVERNIGHT COURIER:                BY HAND:
 --------------------     ---------------------                --------

EquiServe, Inc.           EquiServe, Inc.            EquiServe, Inc.
State Street Bank and     State Street Bank and      Securities Transfer and
  Trust Company             Trust Company            Reporting Services, Inc.
Corporate Reorganization  Corporate Reorganization   c/o EquiServe, Inc.
P.O. Box 9573             40 Campanelli Drive        100 William Street Galleria
Boston, MA 02205-9573     Braintree, MA 02184        New York, NY 10038
U.S.A.                    U.S.A.                     U.S.A.

             DELIVERY TO AN ADDRESS OTHER THAN ONE OF THE ADDRESSES
                LISTED ABOVE WILL NOT CONSTITUTE VALID DELIVERY.

METHOD FOR EXERCISING RIGHTS

Rights are  evidenced by  Subscription  Certificates  that,  except as described
below under "Foreign  Restrictions,"  will be mailed to Record Date Shareholders
or,  if a  shareholder's  Shares  are held by Cede or any  other  depository  or
nominee on their behalf,  to Cede or such  depository or nominee.  Rights may be
exercised  by  completing  and  signing  the   Subscription   Certificate   that
accompanies  this  Prospectus  and  mailing  it in  the  envelope  provided,  or
otherwise  delivering the completed and signed  Subscription  Certificate to the
Subscription  Agent,  together  with  payment  in  full  for the  Shares  at the
Estimated  Subscription  Price  by the  Expiration  Date.  Rights  may  also  be
exercised by contacting your broker, banker or trust company, which can arrange,
on your behalf,  to guarantee  payment and delivery of a properly  completed and
executed Subscription Certificate pursuant to a Notice of Guaranteed Delivery by
the close of business on the third Business Day after the Expiration Date. A fee
may be charged for this service.  Because  fractional Shares will not be issued,
Record Date Shareholders who receive or have remaining fractional Rights will be
unable to purchase  fractional  Shares on the exercise of such remaining  Rights
and will not be entitled to receive any cash in lieu thereof.  For example, if a
Record Date  Shareholder  owns 102 Shares,  that  shareholder  will receive [X#]
Rights,  but may only  exercise  [XXX#]  Rights for the purchase of [XX] Shares,
with  the  unexercised   fractional  Rights  expiring.   However,   Record  Date
Shareholders  holding  fewer than [X#]  Shares  will be entitled to one Right to
subscribe  for one Share  pursuant  to the  Primary  Subscription.  Record  Date
Shareholders  may request  additional  Shares pursuant to the  Over-Subscription
Privilege.  Completed   Subscription   Certificates  must  be  received  by  the
Subscription  Agent prior to 5:00 P.M.,  Eastern time, on the Expiration Date at
one of the addresses set forth above (unless the guaranteed  delivery procedures
are complied with as described below under "Payment for Shares").

SHAREHOLDERS  WHO ARE RECORD  OWNERS.  To  exercise  their  Rights,  Record Date
Shareholders may choose between either option to exercise their Rights set forth
under  "Payment for Shares" below.  If time is of the essence,  option (2) under
"Payment for Shares" below will permit delivery of the Subscription  Certificate
and payment after the Expiration Date.

SHAREHOLDERS  WHOSE SHARES ARE HELD BY A NOMINEE.  Shareholders whose Shares are
held by a nominee such as a bank, broker or trustee must contact that nominee to
exercise their Rights.  In that case, the nominee will complete the Subscription
Certificate on behalf of the  shareholder  and arrange for proper payment by one
of the methods set forth under "Payment for Shares" below.




                                       23
<PAGE>


NOMINEES.  Nominees who hold Shares for the account of others  should notify the
respective  beneficial  owners of such Shares as soon as  possible to  ascertain
such beneficial  owners'  intentions and to obtain  instructions with respect to
the Rights.  If the beneficial  owner so instructs,  the nominee should complete
the Subscription  Certificate and submit it to the  Subscription  Agent with the
proper payment as described under "Payment for Shares" below.

Trustees of the Fund who own Shares through their deferred fee arrangement  will
receive Rights and may  participate in the Offering.  Further  information  with
respect to the deferred  fee  arrangement  may be obtained  from the Fund or the
Investment Manager.

INFORMATION AGENT

Any questions or requests for  assistance  concerning  the method of subscribing
for  Shares  or  for  additional  copies  of  this  Prospectus  or  Subscription
Certificates  or  Notices  of  Guaranteed   Delivery  may  be  directed  to  the
Information Agent at its telephone number and address listed below:

                     Shareholder Communications Corporation
                                 17 State Street
                               New York, NY 10004
                                 (800) 618-7826
             Brokers and banks, please call (800) 877-8579 ext. 113

Record  Date  Shareholders  may also  contact  their  brokers  or  nominees  for
information with respect to the Offer. The Information  Agent will receive a fee
estimated to be [ ], which includes reimbursement for its out-of-pocket expenses
related to the Offer.

PAYMENT FOR SHARES

Shareholders who wish to acquire Shares in the Primary Subscription and pursuant
to the  Over-Subscription  Privilege may choose between the following methods of
payment:

   (1) A shareholder may send the Subscription Certificate together with payment
   for the Shares acquired in the Primary Subscription and any additional Shares
   subscribed   for   pursuant  to  the   Over-Subscription   Privilege  to  the
   Subscription  Agent.  Payment  should  be  calculated  on  the  basis  of the
   Estimated  Subscription Price of [ ] per Share for all Shares  subscribed.  A
   subscription  will  be  accepted  when  payment,  together  with  a  properly
   completed  and  executed  Subscription   Certificate,   is  received  by  the
   Subscription  Agent's office at one of the addresses set forth above no later
   than 5:00 P.M.,  Eastern time, on the Expiration Date. The Subscription Agent
   will deposit all checks and money  orders  received by it for the purchase of
   Shares into a segregated  interest-bearing  account (the  interest from which
   will inure to the benefit of the Fund) pending  proration and distribution of
   Shares.  A PAYMENT  PURSUANT TO THIS METHOD MUST BE IN U.S.  DOLLARS BY MONEY
   ORDER OR CHECK DRAWN ON A BANK OR BRANCH LOCATED IN THE UNITED  STATES,  MUST
   BE PAYABLE TO "INVESCO  GLOBAL  HEALTH  SCIENCES  FUND" AND MUST  ACCOMPANY A
   PROPERLY COMPLETED AND EXECUTED SUBSCRIPTION  CERTIFICATE FOR SUCH PAYMENT TO
   BE  ACCEPTED.  EXERCISE  BY THIS  METHOD IS SUBJECT TO ACTUAL  COLLECTION  OF
   CHECKS  BY  5:00  P.M.,   EASTERN  TIME,  ON  THE  EXPIRATION  DATE.  BECAUSE
   UNCERTIFIED  PERSONAL  CHECKS MAY TAKE AT LEAST FIVE  BUSINESS DAYS TO CLEAR,
 


                                       24
<PAGE>


   SHAREHOLDERS ARE STRONGLY URGED TO PAY, OR ARRANGE FOR PAYMENT, BY MEANS OF A
   CERTIFIED OR CASHIER'S CHECK OR MONEY ORDER.

   (2) Alternatively, a bank, a trust company or a NYSE member subscription will
   be accepted by the Subscription  Agent if, prior to 5:00 P.M.,  Eastern time,
   on the  Expiration  Date,  the  Subscription  Agent has  received a Notice of
   Guaranteed Delivery by facsimile or otherwise from a bank, a trust company or
   a NYSE  member,  guaranteeing  delivery  of  (i)  payment  of  the  Estimated
   Subscription  Price of [$ ] per Share for the  Shares  subscribed  for in the
   Primary  Subscription  and any additional  Shares  requested  pursuant to the
   Over-Subscription  Privilege,  and (ii) a  properly  completed  and  executed
   Subscription  Certificate.  The Subscription Agent will not honor a Notice of
   Guaranteed  Delivery  unless a properly  completed and executed  Subscription
   Certificate  and full payment for the Shares is received by the  Subscription
   Agent by the close of business on the third Business Day after the Expiration
   Date (       , 1999, unless the Offer is extended (the "Protect Period")).

Within five  Business  Days after the end of the Protect  Period (       , 1999,
unless the Offer is extended) (the "Confirmation  Date"), a confirmation will be
sent by the  Subscription  Agent to each  subscribing  shareholder  (or,  if the
shareholder's Shares are held by Cede or any other depository or nominee on such
shareholder's  behalf,  to Cede or such depository or nominee),  showing (i) the
number  of Shares  acquired  in the  Primary  Subscription,  (ii) the  number of
Shares, if any, acquired pursuant to the Over-Subscription  Privilege, (iii) the
Subscription  Price per Share and total purchase  price of the Shares,  and (iv)
any additional  amount payable by such  shareholder to the Fund or any excess to
be  refunded  by the  Fund  to  such  shareholder,  in each  case  based  on the
Subscription  Price.  If any  shareholder  exercises his or her Right to acquire
Shares pursuant to the Over-Subscription Privilege, any such excess payment that
would  otherwise  be  refunded  to the  shareholder  will be applied by the Fund
toward   payment  for  Shares   acquired   pursuant  to  the   exercise  of  the
Over-Subscription  Privilege. Any additional payment required from a shareholder
must be received by the  Subscription  Agent within ten Business  Days after the
Confirmation  Date (       ,  1999,  unless the Offer is  extended).  Any excess
payment  to be  refunded  by the Fund to a  shareholder  will be  mailed  by the
Subscription Agent to such shareholder as promptly as possible.  All payments by
a shareholder must be in U.S. dollars by money order or check drawn on a bank or
branch  located in the United  States and  payable  to  "INVESCO  GLOBAL  HEALTH
SCIENCES FUND."

The Subscription Agent will deposit all checks received by it prior to the final
payment date into a segregated  interest-bearing  account  (which  interest will
inure to the benefit of the Fund)  pending  proration  and  distribution  of the
Shares.

Whichever of the two methods  described above is used,  issuance and delivery of
certificates  for the Shares  purchased  are subject to collection of checks and
actual payment pursuant to any Notice of Guaranteed Delivery.

RECORD DATE SHAREHOLDERS WILL HAVE NO RIGHT TO RESCIND THEIR  SUBSCRIPTION AFTER
RECEIPT  OF THEIR  PAYMENT  FOR  SHARES  BY THE  SUBSCRIPTION  AGENT,  EXCEPT AS
PROVIDED BELOW UNDER "NOTICE OF NET ASSET VALUE DECLINE."

If a shareholder who acquires Shares pursuant to the Primary Subscription or the
Over-Subscription  Privilege does not make payment of any additional amounts due
by the tenth  Business Day after the  Confirmation  Date,  the Fund reserves the
right to take any or all of the following actions:  (i) sell such subscribed and
unpaid-for  Shares to other  Record  Date  Shareholders,  (ii) apply any payment
actually  received  toward the purchase of the  greatest  whole number of Shares



                                       25
<PAGE>


that could be  acquired  by such  shareholder  upon the  exercise of the Primary
Subscription and/or Over-Subscription  Privilege,  and/or (iii) exercise any and
all other rights or remedies to which the Fund may be entitled.

THE METHOD OF DELIVERY TO THE FUND OF SUBSCRIPTION  CERTIFICATES  AND PAYMENT OF
THE SUBSCRIPTION PRICE WILL BE AT THE ELECTION AND RISK OF THE EXERCISING RIGHTS
HOLDERS,  BUT IF SENT  BY MAIL IT IS  RECOMMENDED  THAT  SUCH  CERTIFICATES  AND
PAYMENTS BE SENT BY  REGISTERED  MAIL,  PROPERLY  INSURED,  WITH RETURN  RECEIPT
REQUESTED, AND THAT A SUFFICIENT NUMBER OF DAYS BE ALLOWED TO ENSURE DELIVERY TO
THE  SUBSCRIPTION  AGENT AND  CLEARANCE OF PAYMENT  PRIOR TO 5:00 P.M.,  EASTERN
TIME, ON THE EXPIRATION DATE.  BECAUSE  UNCERTIFIED  PERSONAL CHECKS MAY TAKE AT
LEAST FIVE BUSINESS DAYS TO CLEAR, YOU ARE STRONGLY URGED TO PAY, OR ARRANGE FOR
PAYMENT, BY MEANS OF CERTIFIED OR CASHIER'S CHECK OR MONEY ORDER.

All questions concerning the timeliness,  validity,  form and eligibility of any
exercise of Rights will be determined by the Fund, whose  determinations will be
final and  binding.  The Fund in its sole  discretion  may  waive any  defect or
irregularity,  or permit a defect or  irregularity  to be corrected  within such
time as it may  determine,  or  reject  the  purported  exercise  of any  Right.
Subscriptions  will not be deemed to have been  received or  accepted  until all
irregularities  have been waived or cured  within such time as the  Subscription
Agent  determines in its sole  discretion.  The  Subscription  Agent will not be
under any duty to give  notification of any defect or irregularity in connection
with the  submission  of  Subscription  Certificates  or incur any liability for
failure to give such notification.

EXERCISING RIGHTS HOLDERS WILL HAVE NO RIGHT TO RESCIND THEIR SUBSCRIPTION AFTER
RECEIPT  OF THEIR  PAYMENT  FOR  SHARES  BY THE  SUBSCRIPTION  AGENT,  EXCEPT AS
PROVIDED BELOW UNDER "NOTICE OF NET ASSET VALUE DECLINE."

DELIVERY OF SHARE CERTIFICATES

Certificates  representing  Shares acquired in the Primary  Subscription will be
mailed  promptly  after the  expiration  of the Offer once full payment for such
Shares has been received and cleared.  Certificates representing Shares acquired
pursuant  to  the  Over-Subscription   Privilege  will  be  mailed  as  soon  as
practicable after full payment for such Shares has been received and cleared and
all allocations have been completed.  Participants in the Reinvestment Plan will
have any  Shares  acquired  in the  Primary  Subscription  and  pursuant  to the
Over-Subscription  Privilege  credited to their accounts under the  Reinvestment
Plan.  Participants in the  Reinvestment  Plan wishing to exercise Rights issued
with respect to the Shares held in their  accounts under the  Reinvestment  Plan
must  exercise such Rights in accordance  with the  procedures  set forth above.
Shareholders  whose Shares are held of record by Cede or by any other depository
or nominee on their behalf or their broker-dealer's  behalf will have any Shares
acquired  in the  Primary  Subscription  credited to the account of Cede or such
other depository or nominee.  Shares acquired pursuant to the  Over-Subscription
Privilege will be certificated,  and certificates  representing such Shares will
be sent directly to Cede or such other depository or nominee. Share certificates
will not be issued for Shares credited to Reinvestment Plan accounts.

FOREIGN RESTRICTIONS

Subscription  Certificates will not be mailed to Record Date Shareholders  whose
record addresses are outside the United States. Foreign Record Date Shareholders
or their nominees will receive written notice of the Offer. The Rights issued to
foreign  Record Date  Shareholders  will be held by the  Subscription  Agent for



                                       26
<PAGE>


their accounts until  instructions  are received to exercise the Rights.  Rights
issued to foreign Record Date Shareholders will expire for the failure to submit
instructions to the Subscription Agent prior to or on the Expiration Date.

CERTAIN FEDERAL INCOME TAX CONSEQUENCES OF THE OFFER

The  following   discussion   summarizes   the  principal   federal  income  tax
consequences  of the  Offer  to  Record  Date  Shareholders.  It is based on the
Internal  Revenue  Code  of  1986,  as  amended  (the  "Code"),   U.S.  Treasury
regulations,   Internal  Revenue  Service  rulings  and  policies  and  judicial
decisions in effect on the date of this  Prospectus.  This  discussion  does not
address  all  federal  income tax aspects of the Offer that may be relevant to a
particular  shareholder  in light of his or her individual  circumstances  or to
shareholders  subject to  special  treatment  under the Code (such as  insurance
companies,  financial institutions,  tax-exempt entities, dealers in securities,
foreign corporations and persons who are not citizens or residents of the United
States),  and it does not address any state,  local or foreign tax consequences.
Accordingly,  each shareholder should consult his, her or its own tax advisor as
to the  specific  tax  consequences  of  the  Offer  to  him,  her  or it.  Each
shareholder  should also  review the  discussion  of certain tax  considerations
affecting the Fund and its shareholders set forth under "Federal Taxation of the
Fund and its Shareholders" below and under "Taxation" in the SAI.

For federal  income tax  purposes,  neither the receipt nor the  exercise of the
Rights by Record Date  Shareholders  will result in taxable  income to them, and
they will realize no loss with respect to any Rights that expire  without  being
exercised.

A Record Date Shareholder's holding period for a Share acquired on exercise of a
Right will begin with the date of exercise.  A Record Date  Shareholder's  basis
for  determining  gain or loss on the sale of such a Share will equal the sum of
the  shareholder's  basis in the Right, if any, plus the  Subscription  Price. A
Record Date  Shareholder's  basis in a Right will be zero unless  either (1) the
fair market value of the Right on the date of distribution is 15% or more of the
fair market value on that date of the Shares with respect to which the Right was
distributed or (2) the shareholder elects, on his, her or its federal income tax
return for the taxable year in which the Right is received,  to allocate part of
the basis of those  Shares to the Right.  If either  clause (1) or (2)  applies,
then if the Right is exercised,  the Record Date  Shareholder will allocate his,
her or its basis in the Shares with  respect to which the Right was  distributed
between those Shares and the Right in proportion to their respective fair market
values on the date of  distribution.  A Record Date  Shareholder's  gain or loss
recognized  on a sale of a Share  acquired on the  exercise of a Right will be a
capital gain or loss (assuming the Share was held as a capital asset at the time
of sale)  and will be  long-term  capital  gain or loss if the Share was held at
that time for more than one year.

The foregoing is only a summary of certain federal income tax  consequences  and
does not describe any state or local tax consequences of the Offer.  Record Date
Shareholders   should  consult  their  own  tax  advisors   concerning  the  tax
consequences of the Offer.

NOTICE OF NET ASSET VALUE DECLINE

As required by the SEC,  the Fund has  undertaken  to suspend the Offer until it
amends this Prospectus if, subsequent to [     , 1999]  (the  effective  date of
the Fund's Registration  Statement),  the Fund's NAV declines more than 10% from
its NAV as of that date. Accordingly,  the Expiration Date would be extended and
the Fund would notify  Record Date  Shareholders  of any such decline and permit
shareholders to cancel their exercise of Rights.

                                      27
<PAGE>


EMPLOYEE BENEFIT PLAN CONSIDERATIONS

Shareholders that are employee benefit plans subject to the Employee  Retirement
Income Security Act of 1974, as amended  ("ERISA")  (including  corporate profit
sharing/retirement  and savings plans,  plans for self-employed  individuals and
their employees,  and individual  retirement  accounts  ("IRAs")) (collectively,
"Retirement  Plans") should be aware that additional  contributions of cash to a
Retirement  Plan  (other  than  rollover   contributions  or  trustee-to-trustee
transfers  from other  Retirement  Plans) in order to exercise  Rights may, when
taken  together  with  contributions  previously  made,  be treated as excess or
nondeductible  contributions  subject to excise taxes. In the case of Retirement
Plans qualified under section 401(a) of the Code,  additional cash contributions
could cause violations of the maximum contribution limitations of section 415 of
the Code or other qualification  rules.  Retirement Plans in which contributions
are so limited should  consider  whether there is an additional  source of funds
available within the Retirement Plan,  including the liquidation of assets, with
which to exercise the Rights.  Because the rules  governing  plans are extensive
and  complex,  Retirement  Plans  contemplating  the  exercise of Rights  should
consult with their counsel prior to such exercise.

Retirement Plans and other tax exempt entities,  including  governmental  plans,
should  also be aware that if they borrow to finance  their  exercise of Rights,
they may become  subject to the tax on unrelated  business  taxable income under
section  511 of the Code.  If any  portion of an IRA is used as  security  for a
loan, that portion will be treated as a distribution to the IRA owner.

ERISA contains  fiduciary  responsibility  requirements,  and ERISA and the Code
contain prohibited  transactions  rules, that may impact the exercise of Rights.
Due to the  complexity  of these  rules  and the  penalties  for  noncompliance,
Retirement Plans should consult with their counsel regarding the consequences of
their exercise of Rights under ERISA and the Code.

DISTRIBUTION ARRANGEMENTS

PaineWebber  Incorporated,  1285 Avenue of the Americas,  New York,  New York, a
broker-dealer  and member of the National  Association  of  Securities  Dealers,
Inc., will act as the Dealer Manager for the Offer.  Under the terms and subject
to the  conditions  contained  in the Dealer  Manager  Agreement  dated the date
hereof,  the Dealer  Manager  will  provide  financial  advisory  and  marketing
services in  connection  with the Offer and will  solicit the exercise of Rights
and   participation   in  the   Over-Subscription   Privilege   by  Record  Date
Shareholders.  The Offer is not  contingent  upon any  number  of  Rights  being
exercised.  The Fund has  agreed to pay the Dealer  Manager a fee for  financial
advisory and marketing  services equal to [1.25%] of the aggregate  Subscription
Price for each Share issued pursuant to the Offer,  and the Fund has also agreed
to pay broker-dealers, including the Dealer Manager, fees for their solicitation
efforts (the  "Solicitation  Fees") of 2.50% of the Subscription Price per Share
for each Share issued pursuant to the exercise of the Rights and pursuant to the
Over-Subscription   Privilege   as  a  result  of  their   soliciting   efforts.
Solicitation Fees will be paid to the broker-dealer designated on the applicable
portion of the Subscription Certificates or, in the absence of such designation,
to the Dealer Manager.

In  addition,  the Fund has  agreed to  reimburse  the  Dealer  Manager up to an
aggregate of [$_______] for its reasonable  expenses incurred in connection with
the Offer. The Fund and the Investment  Manger have each agreed to indemnify the
Dealer  Manager or  contribute  to losses  arising  out of  certain  liabilities
including  liabilities  under the Securities  Act. The Dealer Manager  Agreement
also  provides  that the Dealer  Manager will not be subject to any liability to
the Fund in rendering the services contemplated by such agreement except for any
act of  bad faith, willful misconduct  or gross negligence of the Dealer Manager
or reckless  disregard by the Dealer Manager of its obligations and duties under
such agreement.

                                       28
<PAGE>


The Fund has agreed not to offer or sell,  or enter into any  agreement to sell,
any equity or equity  related  securities of the Fund or securities  convertible
into  such  securities  for a period of 180 days  after  the date of the  Dealer
Manager Agreement,  except for the Shares issued in reinvestment of dividends or
other distributions or other limited circumstances.

DILUTION

Upon the  completion  of the Offer,  Record Date  Shareholders  who do not fully
exercise their Rights will own a smaller proportional  interest in the Fund than
they owned prior to the Offer. In addition,  because the Subscription  Price per
Share  will be less than the NAV per Share on the  Expiration  Date and the Fund
will incur  expenses in connection  with the Offer,  the completion of the Offer
will  result in an  immediate  dilution  of NAV per Share for all  shareholders,
which will  disproportionately  affect  shareholders  who do not exercise  their
Rights in full.  Although it is not  possible to state  precisely  the amount of
such  decrease  in NAV per Share,  because it is not known at this time what the
NAV per Share will be on the Expiration  Date, or what  proportion of the Rights
will be exercised,  or what the Subscription  Price will be, such dilution could
be  significant.  For  example,  assuming  all of the  Shares  are  sold  at the
Estimated  Subscription  Price and after  deducting all expenses  related to the
issuance  of  the  Shares,  the  Fund's NAV per Share on [     , 1999] would  be
reduced  by  approximately  $_____ or ____%  (or,  in the event  that all of the
Rights are  exercised  and the Fund  increases  the number of Shares  subject to
subscription   by  25%   pursuant  to  the   Over-Subscription   Privilege,   by
approximately    $______   or   _____%).   See   "Risk   Factors   and   Special
Considerations--Dilution."


IMPORTANT DATES TO
   REMEMBER            EVENT                            DATE
                       -----                            ----

                       Record Date                      [            ]
                      
                       Subscription Period              [            ]*

                       Expiration Date and Pricing      [            ]*
                       Date

                       Subscription Certificates and    [            ]*
                       Payment for Shares Due**

                       Notice of Guaranteed Delivery    [            ]*
                       Due
                       
                       Payment for Guarantees of        [            ]*
                       Delivery Due

                       Confirmation Mailed to           [            ]*
                       Participants

                       Final Payment for Shares***      [            ]*

- --------
*   Unless the Offer is extended.

**  A Record Date  Shareholder exercising  Rights must deliver by the Expiration
Date  either (i) a  Subscription  Certificate  and  payment for Shares or (ii) a
Notice of Guaranteed Delivery.

*** Additional amount due from Record Date Shareholders (in the event the Final
Subscription Price exceeds the Estimated Subscription Price).

                                 USE OF PROCEEDS

If [      ] Shares  are sold at the  Estimated  Subscription  Price of $____ per
Share,  net proceeds of the Offer are estimated to be  approximately  $________,
after deducting  estimated expenses payable by the Fund,  including the fees and


                                       29
<PAGE>


expenses of the Dealer  Manager and other  offering  expenses  that in total are
estimated  to be [$     ]. If the Fund increases  the  number of Shares  subject
to  subscription  by  up  to  25%,  or [       ] Shares,  in  order  to  satisfy
over-subscription  requests,  the additional net proceeds will be  approximately
$________.

The  Investment  Manager has advised the Fund that it  anticipates  that the net
proceeds will be invested in accordance  with its  investment  objective and the
policies set forth under "Investment Objective and Policies" within three months
from the date of this Prospectus (but in no event later than six months from the
date of this Prospectus), depending on market conditions and the availability of
appropriate securities. The proceeds of the Offer may be held in U.S. Government
securities and other  high-quality,  short-term money market  instruments  until
they are  invested  pursuant  to the  Fund's  investment  objective.  While  the
proceeds are invested in such  securities  the proceeds  will not be invested in
securities  consistent  with  the  Fund's  goal  of  seeking  long-term  capital
appreciation.  In addition,  consistent with the Fund's investment restrictions,
the  proceeds of the Offer may be held  pending  permanent  investment  in other
instruments  including,   without  limitation,  S&P  500  futures.  These  other
investments may present a substantial  investment risk,  including the potential
that they may  decrease in value prior to the time they are  liquidated  and the
proceeds are ultimately invested.


                        INVESTMENT OBJECTIVE AND POLICIES

The  investment  objective  of the  Fund  is to  seek  capital  appreciation  by
investing  substantially  all of its assets in equity and related  securities of
U.S.  and  foreign  Health  Science  Companies.  The Fund's  Investment  Manager
believes that the securities of Health Science Companies offer the potential for
capital   appreciation  based  upon  the  Investment   Manager's  projection  of
increasing  global   expenditures  for  health  science  products  and  services
resulting from enhanced consumer demand,  continuing  technological advances and
demographic trends indicating an aging population. The Fund's Investment Manager
also  believes that the  potential  for capital  appreciation  within the health
science  industries  will be driven by increased  focus on cost  containment and
productivity  enhancement.  An  investment  in the Fund  should  not  itself  be
considered   a  balanced   investment   program   and  is  intended  to  provide
diversification  for a more  complete  investment  program.  No assurance can be
given that the Fund will achieve its investment objective.

Under normal market conditions,  at least 80% of the Fund's total assets will be
invested in equity and  related  securities  of Health  Science  Companies.  The
principal industry groups of Health Science Companies are:

      .      Pharmaceuticals

      .      Biotechnology

      .      Medical equipment, devices and supplies

      .      Health care delivery

Health Science Companies also consist of those companies  principally engaged in
any other  industries  relating  to human  health or the growth or  survival  of
animals or plants and companies  principally  engaged in activities that utilize
technologies  that are the same as or similar to those  developed for or used by
Health   Science   Companies.   The  Fund  expects  to  invest  both  in  large,
well-established Health Science Companies with existing products and services as
well as in  smaller,  emerging  Health  Science  Companies,  including  start-up



                                       30
<PAGE>

companies and venture capital opportunities, which may offer limited products or
services or which are seeking to develop products, services or technologies.

Up to 20% of the Fund's  total  assets may be invested,  in the  aggregate,  in:
equity and related securities of companies  engaged,  but less than principally,
in the health  sciences or in  supplying  goods or  services  to Health  Science
Companies,  or of non-Health Science Companies which benefit from the growth and
development of Health Science Companies or in real estate investment trusts that
hold at least 50% of their  interests in facilities of Health Science  Companies
("Related  Companies");   non-convertible  debt  securities  of  Health  Science
Companies  and Related  Companies  that are not acquired as units  together with
equity  securities;   and  high  grade  U.S.  dollar  denominated  money  market
instruments having maturities of one year or less. Investment in non-convertible
debt  securities  (other  than  money  market  instruments)  of  Health  Science
Companies  and Related  Companies  (whether or not  acquired as units with other
securities)  is limited to 10% of the Fund's  total  assets.  Current  income is
generally not a consideration in the selection of investments.

The Fund has pending before the SEC an application  for an exemptive order that,
if  granted,  would  permit  the Fund to  participate  in an  interfund  lending
facility.  As  such,  the Fund may  lend  cash to  other  registered  investment
companies   (including   mutual  funds)  managed  by  the   Investment   Manager
("Affiliated Funds"). If this application is granted, the Fund may from time-to-
time make such  loans to  Affiliated  Funds,  and may make such  loans  from the
proceeds of the  Offering,  if such proceeds  have not been  otherwise  invested
consistent with the Fund's objective.

The Fund may invest up to 25% of its total assets in securities  for which there
is no readily  available  secondary  market,  including  securities  acquired in
private   placements,   venture  capital   opportunities,   joint  ventures  and
partnerships.   Since  its  inception,  the  Fund  has  consistently  made  such
investments.

Up to 25% of the Fund's total assets,  measured at the time of purchase,  may be
invested in Foreign Securities.  Securities of Canadian issuers and ADRs are not
subject to this 25% limitation.

The Fund will, under normal conditions,  invest at least 65% of its total assets
in  issuers  that  are  organized  under  the laws of,  or that  maintain  their
principal  business  operations  in, at least three  countries,  one of which is
expected to be the United States.

"Equity and related  securities"  consist of: common,  preferred and convertible
preferred  stocks,  whether or not  voting;  partnership  interests;  securities
having equity  characteristics  such as rights,  warrants and  convertible  debt
securities,  whether  or not  issued by the same  issuer as the  security  to be
issued upon exercise or conversion;  non-convertible  debt  securities  that are
acquired  as  units  together  with  any  of  the  foregoing,   whether  or  not
transferable or separately  traded;  and short sale and hedge positions relating
to any of such securities.

The  Fund  may  utilize  certain  investment   practices,   such  as  repurchase
agreements,  when-issued and delayed delivery  transactions,  lending  portfolio
securities,  foreign  currency and other hedging  transactions  and short sales.
These investment  practices  involve certain risks. See "Additional  Information
About Its Investment Objective and Policies" located in the SAI.

For  temporary  purposes,  and  when,  in  the  Investment  Manager's  judgment,
conditions  in the  securities  markets  generally  or in  the  market  for  the
securities of Health  Science  Companies  would make  achievement  of the Fund's
investment objective  impracticable,  the Fund may assume a defensive investment
position.  During  these  periods,  the Fund may  without  limit  invest in U.S.


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<PAGE>


dollar-denominated, high grade money market instruments rated or, if unrated, in
the Investment  Manager's  opinion  comparable to instruments  rated, in the top
three rating categories utilized by at least one national recognized statistical
rating organization and having maturities at the time of purchase of one year or
less,  including securities issued or guaranteed by the United States Government
or one of its  agencies or  instrumentalities  ("U.S.  Government  Securities"),
certificates of deposit,  bankers'  acceptances,  commercial  paper,  short-term
corporate  securities,  and  repurchase  agreements  with  respect to any of the
foregoing. While the Fund is in a defensive position, the opportunity to achieve
capital  appreciation  will be limited,  and, to the extent that the  Investment
Manager's  assessment  of  market  conditions  is  incorrect,  the Fund  will be
foregoing the  opportunity to benefit from capital  appreciation  resulting from
increases in the value of equity investments; however, the ability to maintain a
defensive  investment  position provides the flexibility for the Fund to seek to
avoid capital loss during market downturns. It is impossible to predict when, or
for how long, any such investment position will be maintained.

INVESTMENT RESTRICTIONS

The Fund has adopted the following investment restrictions, which, together with
its investment  objective,  are  fundamental  policies  changeable only with the
approval of a "majority" of the Fund's outstanding voting securities. As defined
in the 1940 Act, this requires the  affirmative  vote of the holders of (a) more
than 50% of the outstanding Shares of the Fund, or (b) two-thirds or more of the
Shares  present at a meeting if more than 50% of the Fund's  outstanding  Shares
are represented at the meeting in person or by proxy,  whichever is less.  Under
these restrictions, the Fund may not:

      1. borrow  money  or issue  senior  securities,  except  that the Fund may
         borrow in an amount not  exceeding  15% of its total  assets to finance
         the  repurchase  of or tender offers for Shares or to pay dividends and
         other distributions, and may borrow for temporary purposes in an amount
         not  exceeding  5% of its total  assets (the Fund will not be deemed to
         have  issued a senior  security  by reason of  effecting  short  sales,
         lending securities,  purchasing  securities on a when-issued or delayed
         delivery basis, or engaging in hedging  transactions in accordance with
         its investment  policies,  or entering into collateral  arrangements or
         maintaining   margin   deposits   incident  to  any  of  the  foregoing
         practices);

      2. buy or sell commodities, commodity contracts, oil, gas or other mineral
         interests  or  exploration  programs  (however,  the Fund may  purchase
         securities  of companies  which invest in the  foregoing  and may enter
         into transactions in hedging instruments);

      3. buy or sell  real  estate or  interests  therein  (however,  securities
         issued by companies  which  invest in real estate or interests  therein
         may be purchased and sold);

      4. invest  in any  company  for  the  purpose  of  exercising  control  or
         management,  except  to the  extent  that  exercise  by the Fund of its
         rights under agreements related to portfolio securities would be deemed
         to constitute such control;

      5. engage in the  underwriting  of any  securities,  except insofar as the
         Fund may be deemed an  underwriter  under the Securities Act of 1933 in
         the sale of its Shares or in disposing of a portfolio security;

      6. make loans of money or securities  to any person,  except that the Fund
         may lend money through the purchase of securities (including repurchase



                                       32
<PAGE>

         agreements) in accordance with its investment policies,  and make loans
         of portfolio  securities  in an amount not  exceeding 25% of the Fund's
         total assets;

      7. with respect to 75% of its total assets, purchase the securities of any
         one issuer  (except U.S.  Government  Securities) if the purchase would
         cause the Fund to have  more  than 5% of the value of its total  assets
         invested  in the  securities  of such issuer or to own more than 10% of
         the outstanding voting securities of such issuer;

      8. invest in the securities of other  investment  companies in an amount
         exceeding  the  limitations  set  forth in the 1940 Act and the rules
         thereunder;

      9. purchase a security if such  purchase  would cause more than 25% of its
         total assets to be invested in securities of issuers engaged in any one
         industry (as  determined by standard  industry  classification  codes),
         except that the Fund will, under normal market conditions,  invest more
         than 25% of its total  assets in the  securities  of  companies  in the
         groups of industries in which Health Science Companies are engaged; or

      10.pledge, hypothecate,  mortgage or otherwise encumber its assets, except
         to  secure   permitted   borrowings  or  for   collateral   and  margin
         arrangements associated with the Fund's investment practices.

The  percentage  limitations on  investments  set forth above,  as well as those
described  elsewhere  in this  Prospectus  and  SAI,  apply  only at the time of
investment  and require no action by the Fund as a result of subsequent  changes
in the value of investments or the total assets of the Fund.

SPECIAL INVESTMENT PRACTICES

The Fund may utilize the following special investment practices:

SHORT SALES. In furtherance of its objective of capital  appreciation,  the Fund
may effect  short sales of any  securities  which it has  authority to purchase,
subject  to the  limitation  that the Fund will not effect a short sale if, as a
result of such sale,  the current  market value of  securities  sold short would
exceed 25% of the Fund's total assets. Short sales are transactions in which the
Fund sells a security it does not own in anticipation of an expected  decline in
the price of that  security.  In such a  transaction,  the Fund must  borrow the
security to make  delivery to the buyer.  The Fund is  obligated  to replace the
borrowed  security  and may  realize a gain if it  purchases  the  security  for
replacement at a lower price. However, the price at which the Fund purchases the
security may be more or less than the price at which the security was sold.  The
Fund will incur a loss as a result of a short sale if the cost of purchasing the
borrowed security,  and transaction and carrying costs associated with the short
sale, are more than the amount realized from the short sale. Although the Fund's
potential  for gain as a result of a short sale is limited to the price at which
it sold the  security  short  less  the  cost of  borrowing  the  security,  its
potential for loss is theoretically  unlimited  because there is no limit to the
cost of replacing the borrowed security.

If the Fund borrows a security in order to enter into a short sale, the proceeds
of the short sale will be retained by a broker, as security for the borrowing to
the extent  necessary to meet margin  requirements,  until the short position is
closed out.  The Fund is also  required to pay to the lender of the security the
amount of any dividends or interest paid on the borrowed security. To borrow the
security,  the Fund also may be required to pay a premium,  which would increase
the cost of the security  sold short.  The amount of any gain will be decreased,
and the amount of any loss increased,  by the amount of any premium or dividends



                                       33
<PAGE>

or interest  paid on the borrowed  security that the Fund may be required to pay
in connection with the short sale.

A short sale "against the box" is a transaction  in which the Fund enters into a
short  sale of a  security  that the Fund owns or has the right to acquire at no
additional  cost.  The proceeds of the short sale are held by a broker until the
Fund delivers the security to close the short  position,  at which time the Fund
will receive the net proceeds from the sale.

When the Fund engages in short sales other than "against the box," the Fund will
"cover" its  position  in one of two ways.  The Fund may cover by holding a call
option on the security sold short having a strike price no higher than the price
at which the  security  was sold.  Alternatively,  the Fund may  maintain  in an
account  with its  custodian  a  segregated  amount  of cash or U.S.  Government
Securities  equal to the excess of (1) the market value of the  securities  sold
short at the time  they were sold  short,  over (2) any cash or U.S.  Government
Securities  required by the broker to be deposited as  collateral  in connection
with the short sale (not including the proceeds from the short sale).  Until the
borrowed security is replaced, the Fund will maintain this account at a level so
that the amount deposited in the account, plus the collateral deposited with the
broker,  will equal the current market value of the securities  sold short,  but
not less  than the  market  value of the  securities  at the time they were sold
short.

HEDGING.  For hedging  purposes,  the Fund may purchase and sell stock  options,
stock index futures, such as S&P 500 futures,  options on stock indices, options
on stock index futures,  forward foreign currency contracts and foreign currency
futures  contracts and related options  (collectively,  "Hedging  Instruments").
Hedging  Instruments may be used to attempt to reduce  investment risk by taking
an investment  position that is expected to move in the opposite  direction from
the  position  being  hedged.  The Fund may enter into hedging  transactions  in
connection with anticipated  purchases or sales of portfolio  securities or with
respect to anticipated  changes in the market prices for securities which are in
its portfolio.  To the extent the hedge is  successful,  a loss (or gain) on one
position will tend to be offset by a gain (or loss) on the other. The Investment
Manager will not engage in financial futures or related options transactions for
speculative purposes but only in an effort to hedge portfolio risks as described
above. The Fund will only invest in futures contracts and related options to the
extent that the Fund would not be required  thereby to register  with the United
States Commodity Futures Trading Commission as a commodity pool operator.  Under
current  regulations,  the Fund may not  purchase or sell  futures  contracts or
related  options if,  immediately  thereafter,  the sum of the amount of initial
margin deposits on the Fund's open regulated  options and futures  positions and
premiums on open option positions thereon would exceed 5% of the market value of
the Fund's total assets.

The  successful  use  of  Hedging  Instruments  depends  on the  ability  of the
Investment  Manager to  predict  the  direction  of the market and is subject to
various  additional risks. The investment  techniques and skills required to use
Hedging  Instruments  successfully  are different  from those required to select
equity securities for investment. The correlation between movements in the price
of the  Hedging  Instruments  and the price of the  securities  being  hedged is
imperfect and the risk from  imperfect  correlation  increases,  with respect to
stock  index  related  Hedging  Instruments,  as the  composition  of the Fund's
portfolio  diverges from the  composition of the index  underlying  such Hedging
Instruments.  If the Fund has  hedged  against  a  decline  in the  value of its
portfolio  securities,  the Fund  could  suffer a loss  which is only  partially
offset or not offset at all by an increase in the value of the Fund's  portfolio
securities. If the Fund has hedged an intended purchase of securities,  the Fund
could  suffer a loss  which is only  partially  offset or not offset at all by a
reduction in the price at which the securities are purchased. If the Fund hedges
a  proposed   purchase  of  securities  and  determines  not  to  purchase  such
securities,  any loss on the Hedging Instrument will not be offset. In addition,
the ability of the Fund to close out a position in a Hedging  Instrument depends



                                       34
<PAGE>

on a liquid  secondary  market.  There is no  assurance  that  liquid  secondary
markets will exist for any particular Hedging Instrument at any particular time.

The Fund may enter into  contracts to purchase or sell foreign  currencies  at a
future date ("forward contracts") foreign currency futures contracts, options on
such futures  contracts  and options on foreign  currencies  as a hedge  against
fluctuations in foreign exchange rates pending the settlement of transactions in
Foreign  Securities  or during the time the Fund  holds  Foreign  Securities.  A
forward foreign currency contract is an agreement between contracting parties to
exchange an amount of  currency at some future time at an agreed upon rate.  The
Fund will not attempt to hedge all of its foreign  portfolio  positions and will
enter into such transactions  only to the extent, if any, deemed  appropriate by
the Investment  Manager.  The Fund will not enter into a forward  contract for a
term of more than one year.  Investors  should be aware that  hedging  against a
decline in a currency  does not  eliminate  fluctuations  in the market value of
portfolio securities or prevent losses if the value of such securities declines.
Furthermore,  such hedging transactions preclude the opportunity for gain if the
hedged  currency should rise. No predictions can be made with respect to whether
the total of such  transactions will result in a better or a worse position than
had the Fund not entered into foreign currency hedges.

The Hedging  Instruments  that the Fund may use are described in the SAI,  which
contains  further  information  about  the  characteristics,   risks,   possible
benefits, and applicable limitations on the use of such Hedging Instruments.

REPURCHASE  AGREEMENTS.  In order to make  productive use of funds pending other
investments,  any of the types of high grade  debt  securities  permissible  for
purchase  by the Fund may be  acquired  subject to  repurchase  agreements  with
commercial banks with total assets in excess of $1 billion or securities dealers
with a net worth in excess of $50  million.  The  Investment  Manager  will also
consider  the  creditworthiness  of the  parties  with whom the Fund enters into
repurchase  agreements.  In a  repurchase  transaction,  at the  time  the  Fund
acquires a security, it simultaneously agrees to resell it to the bank or dealer
from which it was  purchased on a specific  future date.  The  repurchase  price
exceeds the purchase  price by an amount that  reflects an agreed upon  interest
rate  effective  for the period  during  which the  repurchase  agreement  is in
effect. Delivery pursuant to the resale typically will occur within one to seven
days of the purchase.  A repurchase  transaction is similar to a loan,  with the
security underlying the agreement serving as collateral.  The Fund requires that
securities  underlying  repurchase  agreements  be held by its  custodian  in an
amount having a value at least equal to the  repurchase  price.  The  Investment
Manager will monitor the  collateral  daily and, if its value declines below the
repurchase  price,  will  immediately  demand  that  additional   securities  be
transferred.  If such demand is not met within one day, the  securities  will be
sold by the Fund. If any party to a repurchase agreement fails to pay the agreed
upon resale price on the delivery  date, the Fund's risks include any decline in
the  value  of the  collateral  to an  amount  which  is less  than  100% of the
repurchase price, any costs of disposing of such collateral, and any loss from a
delay in  disposing  of the  collateral.  There is no limit on the amount of the
Fund's assets that may be subject to repurchase agreements.

                     RISK FACTORS AND SPECIAL CONSIDERATIONS

DILUTION.  If you do not  exercise  all of your Rights  during the  Subscription
Period,  when the Offering is over you will own relatively less of the Fund than
if you had exercised all of your Rights.  The Fund cannot tell you precisely how
much less of the Fund you would own  because  the Fund does not know how many of
the Fund's Record Date  Shareholders  will exercise their Rights and how many of
their Rights they will exercise.


                                      35
<PAGE>

Shareholders  will experience an immediate  dilution of the aggregate NAV of the
Shares as a result of the Offer because the Subscription Price per Share will be
less than the  Fund's  NAV per Share on the  Expiration  Date (and the Fund will
incur  expenses  in  connection  with  the  Offer),  and the  number  of  Shares
outstanding  after the Offer  will  increase  in a greater  percentage  than the
increase in the size of the Fund's assets. Such dilution will disproportionately
affect  Record  Date  Shareholders  who do not  exercise  their  Rights in full.
Although it is not possible to state  precisely  the amount of any such decrease
in NAV,  because  it is not known at this time what the NAV per share will be at
the Expiration  Date or what  proportion of the Shares will be subscribed,  such
dilution could be significant.  For example, assuming all the Shares are sold at
the Estimated  Subscription Price of __________ and after deducting all expenses
related  to  the  issuance  of  the  Shares,  then  the  Fund's NAV per share on
[       ], 1999 would be reduced by approximately ____ per share or ____ %.

HEALTH SCIENCE COMPANIES.  Because the Fund intends to invest  substantially all
of its assets in equity and related securities of Health Science  Companies,  an
investor  should be aware of certain  special  considerations  and risk  factors
relating to  investment  in such  companies.  Investors  should also be aware of
considerations  and  risks  relating  to the  Fund's  investment  practices.  An
investment  in the Fund should not be considered a balanced  investment  program
and is  intended  to  provide  diversification  for a more  complete  investment
program. The Fund is not intended for investors seeking income.

Investment  in the  securities  of  Health  Science  Companies  entails  special
considerations  and risks. In addition to the risks associated with any strategy
seeking capital appreciation through investment in equity securities, the Fund's
portfolio will bear the additional  risk that many Health Science  Companies may
be subject to, and  possibly  adversely  affected  by, some of the same  general
trends relating to demand for health related  products and services and the same
regulatory,  economic, and political factors.  Certain health science industries
are  characterized  by single product focus and rapidly  changing  technologies.
These changes may render existing products and technologies  obsolete.  There is
also extensive government regulation of certain health science industries.  Many
of these  activities are funded or subsidized by federal and state  governments;
withdrawal or  curtailment  of this support could have an adverse  impact on the
profitability,  and market  prices,  of such  companies.  Changes in  government
regulation could also have an adverse impact.  Unanticipated  problems may arise
in connection  with the  development of new products or  technologies,  and many
such efforts may ultimately be unsuccessful.  In addition,  testing or marketing
products may require obtaining government approvals,  which may be a lengthy and
expensive process with an uncertain outcome.  Delays in generating  products may
result  in the  need  to  seek  additional  capital,  potentially  diluting  the
interests of existing  investors,  such as the Fund.  These various  factors may
result in abrupt  advances and declines in the  securities  prices of particular
companies  and,  in  some  cases,  may  have a broad  effect  on the  prices  of
securities of companies in  particular  health  science  industries or of Health
Science Companies generally.

INVESTMENTS  IN UNSEASONED  COMPANIES.  The Fund may invest in the securities of
smaller,  less  seasoned  companies.   These  investments  may  present  greater
opportunities  for growth but also involve  greater risks than  customarily  are
associated with investments in securities of more established companies. Some of
the  Health  Science  Companies  in which the Fund may invest  will be  start-up
companies which may have  insubstantial  operational or earnings  history or may
have limited products,  markets,  financial  resources or management depth. Some
may also be emerging  companies at the research  and  development  stage with no
products or  technologies  to market or approved for  marketing.  Securities  of
emerging Health Science Companies may lack an active secondary market and may be
subject to more abrupt or erratic  price  movements  than  securities of larger,
more established  companies or stock market averages in general.  Competitors of
certain  Health  Science  Companies,  which  may or may  not be  Health  Science



                                       36
<PAGE>

Companies,  may have substantially  greater financial resources than many of the
companies in which the Fund may invest.

SUBSTANTIAL  COMPETITION.  Intense  competition  exists within and among certain
health  science  industries,   including   competition  to  obtain  and  sustain
proprietary  technology  protection.  Health  Science  Companies  may be  highly
dependent on the strength of a patent to maintain  revenue and market share. The
complex  nature  of the  technologies  involved  can  lead to  patent  disputes,
including litigation that could result in a company losing an exclusive right to
a patent.  In addition,  there are numerous  Related  Companies and the Fund may
invest only a limited portion of its assets in the securities of such companies.
These  Related  Companies,  although  not  principally  engaged  in  the  health
sciences, may be large,  well-capitalized  companies that are engaged in certain
health  science  businesses.  Some of these  companies  may  have  substantially
greater capital, research and development,  manufacturing,  marketing, and human
resources  capabilities  than certain of the Health Sciences  Companies in which
the Fund may invest and may  represent  significant  long-term  competition  for
Health  Sciences  Companies.   Such  large  Related  Companies  may  succeed  in
developing technologies and products that are more effective or less costly than
any that may be developed by Health  Science  Companies and may also prove to be
more successful in production and marketing. Competition may increase further as
a result of potential  advances in the health sciences and greater  availability
of capital for investment in these fields.

PRODUCT  LIABILITY  EXPOSURE.  Certain  Health  Science  Companies  and  Related
Companies  in which the Fund may invest  will be exposed  to  potential  product
liability  risks that are  inherent in testing,  manufacturing,  marketing,  and
selling human  therapeutic  and diagnostic  products.  There can be no assurance
that a product  liability claim would not have a material  adverse effect on the
business, financial condition or securities prices of the companies in which the
Fund has invested.

FOREIGN  SECURITIES.  The Fund may  invest  substantially  all of its  assets in
Foreign Securities.  Many Foreign Securities may be less liquid and their prices
more  volatile  than  securities of  comparable  U.S.  companies.  Foreign stock
exchanges and brokers are generally subject to less governmental supervision and
regulation  than U.S.  exchanges and brokers,  and  commissions on foreign stock
exchanges are generally higher than negotiated commissions in the United States.
In addition,  there may, in certain  instances,  be delays in the  settlement of
transactions  effected in foreign markets.  Certain  countries  restrict foreign
investments  in  their  securities  markets.  These  restrictions  may  limit or
preclude  investment  in certain  countries or in certain  industries  or market
sectors,  or may  increase the cost of investing  in  securities  of  particular
companies.

Foreign companies are not generally subject to uniform accounting, auditing, and
financial reporting standards or to other regulatory  requirements comparable to
those  applicable  to  U.S.  companies.   Thus,  there  may  be  less  available
information  concerning non-U.S.  issuers of securities held by the Fund than is
available concerning U.S. companies.  In addition,  with respect to some foreign
countries  there  is  the  possibility  of  nationalization,   expropriation  or
confiscatory  taxation.  Income  earned in a foreign  nation  may be  subject to
taxation (including withholding taxes on interest and dividends), or other taxes
may be imposed with respect to  investments in Foreign  Securities.  Other risks
associated with  investments in Foreign  Securities  include  limitations on the
removal of  securities,  property or other assets of the Fund,  difficulties  in
pursuing legal remedies and obtaining judgments in foreign courts,  political or
social instability,  and diplomatic developments that could adversely affect the
Fund's investments in companies located in foreign countries.

CURRENCY  RISK.  The income and  capital  gains  received by the Fund on Foreign
Securities  generally  will  be in  non-U.S.  currencies.  The  computation  and
distribution of income and capital gains by the Fund,  however,  will be made in



                                       37
<PAGE>

U.S.  dollars.  Therefore,  the  Fund's  reported  NAV and its  computation  and
distribution  of  income  and  capital  gains in U.S.  dollars  will  vary  with
increases and decreases in the exchange rate between the currencies in which the
Fund has  invested and the U.S.  dollar.  A decline in any  particular  currency
against  the U.S.  dollar will cause a decline in the U.S.  dollar  value of the
Fund's holdings of securities  denominated in such currency and, therefore,  may
cause an overall decline in the Fund's NAV and net investment income and capital
gains, if any, to be distributed in U.S. dollars to shareholders by the Fund. In
addition,  the  computation of income and capital gains will be made on the date
of its accrual by the Fund  rather than on any later date on which the  proceeds
are converted into U.S. dollars. See "Taxation" in the SAI.

The rate of exchange  between the U.S. dollar and other currencies is determined
by many  factors,  including  the supply and demand for  particular  currencies,
central bank efforts to support particular currencies,  the movement of interest
rates,  the pace of activity in the industrial  countries,  including the United
States, and other economic and financial conditions affecting the world economy.
As discussed  above,  the Fund may enter into foreign  currency  related Hedging
Instruments  to seek to hedge against  fluctuations  in foreign  exchange  rates
pending the settlement of transactions in Foreign  Securities or during the time
the   Fund   holds   Foreign   Securities.   See   "Investment   Objective   and
Policies--Special Investment Practices--Hedging."

EURO CONVERSION.  The recent introduction of a new European currency,  the euro,
may result in future  uncertainties  for European  securities  in the markets in
which they trade and with respect to the operation of the Fund's portfolio.  The
euro was  introduced on January 1, 1999 by eleven  European  countries  that are
members of the European  Economic and Monetary Union. The transition to everyday
usage of the euro will  occur  during the period  from  January 1, 1999  through
December 31, 2001. The introduction of the euro will require the  redenomination
of European debt and equity  securities over a period of time,  which may result
in various accounting differences and/or tax treatments that otherwise would not
likely occur.  Additional questions are raised by the fact that certain European
Union  members,  including  the United  Kingdom,  did not  implement the euro on
January 1, 1999.  If the  remainder of the  transition to the euro does not take
place as  planned,  there  could be negative  effects,  such as severe  currency
fluctuations and market disruptions.

PORTFOLIO TURNOVER. There are no fixed limitations regarding portfolio turnover.
Frequency of portfolio turnover will, therefore, not be a limiting factor if the
Fund  considers  it  advantageous  to  purchase  or sell  securities.  The  Fund
anticipates  that its annual  portfolio  turnover rate will not exceed 200%. For
the year ended October 31, 1998, the Fund's  portfolio  turnover rate was 87%. A
higher rate of portfolio  turnover  involves  correspondingly  greater aggregate
payments for brokerage  commissions  than a lower rate,  which  expenses must be
borne by the Fund and its shareholders, while a lower rate of portfolio turnover
involves correspondingly lower aggregate payments and shareholder expenses.

ILLIQUID  INVESTMENTS.  The Fund is  permitted  to invest up to 25% of its total
assets in securities for which there is no readily  available  secondary market.
The risk of investing in such  securities  generally is greater than the risk of
investing in the securities of widely held,  publicly traded companies.  Certain
of these  securities may be restricted  securities and have legal or contractual
restrictions on resale.  Restricted  securities may not be sold except in exempt
transactions  or in a public  offering  registered  under the  Securities Act of
1933. Adverse conditions in the securities markets at certain times may preclude
a public  offering of an  issuer's  unregistered  securities.  Lack of an active
secondary market and resale restrictions may result in the inability of the Fund
to sell a  security  at a fair price and may  substantially  delay the sale of a
security that the Fund seeks to sell. In addition,  these securities may exhibit
greater price  volatility  than  securities for which  secondary  markets exist.


                                      38
<PAGE>

Companies  whose  securities are not publicly traded are not subject to the same
disclosure  and other legal  requirements  as are  applicable to companies  with
publicly  traded  securities.  Restricted  securities  eligible  for  resale  to
qualified institutional buyers pursuant to Rule 144A under the Securities Act of
1933 that are determined to be liquid by the Board, or by the Investment Manager
under  Board-approved  guidelines,  are  not  subject  to  this  25%  of  assets
limitation. Under guidelines to determine whether securities eligible for resale
under  Rule  144A  are  liquid,   factors  such  as  trading  activity  and  the
availability of price  quotations will be considered.  If trading  activity in a
Rule 144A security  purchased by the Fund  declines,  the Fund's holding in that
security may become illiquid.

Securities of many Health Science  Companies are traded in the  over-the-counter
market, on regional stock exchanges,  and on foreign securities exchanges.  Such
markets and exchanges may have low trading volume, and securities traded on such
markets  and  exchanges  may  experience  abrupt and  erratic  price  movements.
Determinations as to whether a "readily available secondary market" exists for a
particular security will be made by the Board or by the Investment Manager under
Board-approved  guidelines.  Since its inception, the Fund has consistently made
such investments.

JUNK BONDS AND  UNRATED  DEBT  SECURITIES.  The Fund may invest up to 10% of its
total assets in the  aggregate,  in  non-convertible  debt  securities of Health
Science Companies and Related Companies.  These securities and other investments
in such companies may be rated as low as C in the rating categories  established
by  Standard & Poor's and  Moody's or may be  unrated,  if deemed of  comparable
credit quality by the Investment Manager.  These securities,  which are commonly
referred  to as  "junk  bonds,"  are  regarded,  on  balance,  as  predominantly
speculative  in terms of the  capacity  of the issuer to pay  interest  or repay
principal in accordance with the terms of the obligation and accordingly involve
more credit risk than  securities  rated in the higher rating  categories.  Such
debt  securities are dependent upon  favorable  business,  financial or economic
conditions,  may be  subordinated  to senior  debt and can be regarded as having
extremely poor prospects of ever retaining any real investment standing.

The  market  prices of such  securities  tend to  reflect  individual  corporate
developments  to a greater extent than do securities  rated in the higher rating
categories,  which react  primarily  to  fluctuations  in the  general  level of
interest rates. Junk bonds also tend to be more sensitive to economic conditions
than higher  rated  securities.  Adverse  publicity  and  investor  perceptions,
whether or not based on fundamental  analysis,  regarding junk bonds may depress
the prices for such securities.  These and other factors adversely affecting the
market prices of such securities will adversely affect the Fund's NAV.  Although
some risk is inherent in all securities  ownership,  holders of debt  securities
have a claim  on the  assets  of the  issuer  prior  to the  holders  of  equity
securities.  Therefore,  an investment in debt securities generally entails less
risk than an investment in equity securities of the same issuer.

Junk bonds are frequently  issued by  corporations  in the growth stage of their
development.   They  may  also  be  issued  in   connection   with  a  corporate
reorganization  or a corporate  takeover.  Companies that issue such  securities
often are highly  leveraged and may not have available to them more  traditional
methods  of  financing.  Therefore,  the  risk  associated  with  acquiring  the
securities  of such  issuers  generally  is greater than is the case with higher
rated securities.  For example, during an economic downturn such issuers may not
have  sufficient  revenues  to meet  their  interest  payment  obligations.  The
issuer's ability to service its debt obligations may also be adversely  affected
by specific  corporate  developments,  the issuer's  inability to meet  specific
projected business forecasts or the unavailability of additional financing.  The
risk of loss from default by the issuer is significantly greater for the holders
of such securities  because such securities are often unsecured and subordinated
to other creditors of the issuer.


                                       39
<PAGE>

The Fund may have difficulty disposing of junk bonds and unrated debt securities
because they may not have an active secondary market.  The market for junk bonds
has been  subject  to periods of  illiquidity.  The lack of an active  secondary
market may have an  adverse  effect on market  prices and the Fund's  ability to
dispose of particular issues and may also make it more difficult for the Fund to
obtain accurate market quotations for purposes of valuing these securities.

NET  ASSET  VALUE  DISCOUNT.  Shares  of  closed-end  funds,  such as the  Fund,
frequently  trade at a discount  from their NAV;  that is, the market  price per
share is less  than the value  per  share of the net  assets  of the fund.  This
characteristic is a risk separate and distinct from the risk that the Fund's NAV
will decrease as a result of its  investment  activities  and may be greater for
investors  expecting to sell their Shares in a relatively short period following
completion of this Offering.  It should be noted,  however,  that shares of some
closed-end  funds,  including the Fund, have traded at premiums to NAV. The Fund
cannot predict whether the Shares will trade at, above or below NAV.

If, at any time, Shares are trading at a substantial discount from NAV, the Fund
may take action to reduce or eliminate the discount from NAV at which Shares are
trading.  Such actions could include,  among other things,  purchasing Shares in
open market  transactions or pursuant to a cash tender offer, or recommending to
Fund  shareholders  that the Fund  convert to an  open-end  investment  company.
Conversion to an open-end  investment  company would make the Shares  redeemable
upon demand by  shareholders  at prices  based upon the then  current  NAV.  See
"Conversion to Open-End Status."

DIVIDENDS & OTHER DISTRIBUTIONS.  Based on current market condition  information
provided by the  Investment  Manager,  the Board of Trustees  believes  that the
Offer will not result in a change in the Fund's  current  level of dividends per
Share for the foreseeable  future.  The Board of Trustees has agreed to maintain
an annual  dividend  of at least 10% until  February  19,  2001  pursuant to its
Quarterly  Distribution  Policy.  However,  after  that  date,  there  can be no
assurance  that the Fund will maintain its current level of dividends per Share,
and  thereafter  the Board of Trustees may, in its sole  discretion,  change the
Fund's  current  dividend  policy or its current level of dividends per Share in
response to market or other conditions.

YEAR 2000.  INVESCO has committed  substantial  resources  and made  significant
progress  toward  making  sure its  computer  systems  will  continue to operate
smoothly through the year 2000, and expects that its business partners also will
be prepared for the year 2000.  While INVESCO does not anticipate  interruptions
in its business,  investors  should be aware of the possible risks. As is widely
known,  there is a chance  that some  computer  systems may not  function  after
December  31, 1999  because  they fail to  recognize  dates in the year 2000 and
beyond.  If a system at INVESCO or one of its business  partners should fail, it
could  adversely  affect the Fund.  In addition,  the markets for, or values of,
securities in which the Fund invests  could be affected by computer  failures on
or after January 1, 2000.  While INVESCO cannot make  assurances  that this will
not happen,  it continues to  thoroughly  analyze the  securities  that the Fund
invests in, including the possible effects of the year 2000 computer problems on
a company or the market the security trades in.

WHEN-ISSUED AND FORWARD  DELIVERY  SECURITIES.  Securities may be purchased on a
"when-issued" or on a "forward delivery" basis, which means that the obligations
will be  delivered  at a future  date  beyond  customary  settlement  time.  The
commitment  to purchase a security  for which  payment  will be made on a future
date may be deemed a separate security.  Although the Fund is not limited in the
amount of  securities  for which it may have  commitments  to  purchase  on such
basis, it is expected that in normal circumstances the Fund will not commit more
than  30% of its  assets  to  such  purchases.  The  Fund  does  not pay for the
securities until received or start earning interest on them until it is notified


                                      40
<PAGE>

of the  settlement  date.  In order to  invest  its  assets  immediately,  while
awaiting delivery of securities  purchased on such basis, the Fund will normally
invest in short-term  securities that offer same-day settlement and earnings but
that may bear interest at a lower rate than longer-term securities.

These  transactions  are  subject  to  market  fluctuation;  the  value  of  the
securities at delivery may be more or less than their purchase price, and yields
generally available on comparable  securities when delivery occurs may be higher
than yields on the securities  obtained pursuant to such  transactions.  Because
the Fund relies on the buyer or seller,  as the case may be, to  consummate  the
transaction,  failure by the other party to complete the  transaction may result
in the Fund's missing the  opportunity of obtaining a price or yield  considered
to be  advantageous.  The Fund will make  commitments to purchase  securities on
such basis only with the intention of actually  acquiring these securities,  but
it may  sell  such  securities  prior  to the  settlement  date if such  sale is
considered to be advisable.  When the Fund engages in "when issued" and "forward
delivery"  transactions,  it will do so for the purpose of acquiring  securities
for its portfolio  consistent with its investment objective and policies and not
for the purpose of investment leverage.

The SEC generally  requires that when  investment  companies,  such as the Fund,
effect  transactions of the foregoing nature, they must either segregate cash or
liquid  portfolio  securities  in the  amount  of their  obligations  under  the
foregoing  transactions  or cover such  obligations by maintaining  positions in
portfolio  securities,  futures contracts or options that would serve to satisfy
or offset  the risk of such  obligations.  When  effecting  transactions  of the
foregoing  nature,  the Fund will comply with such segregation or asset coverage
requirements.  There is no limitation as to the  percentage of the Fund's assets
that may be invested in such transactions.

 
                             MANAGEMENT OF THE FUND

INVESTMENT MANAGER

INVESCO has served as the Fund's investment adviser since February 4, 1998 under
an investment advisory agreement ("Investment Management  Agreement").  Prior to
that time, INVESCO Trust Company ("ITC"),  then a wholly owned subsidiary of the
Investment  Manager,  served as the Fund's  investment  adviser.  The  principal
address of the Investment  Manager is 7800 E. Union Avenue,  Suite 800,  Denver,
Colorado 80237.  INVESCO is an indirect wholly owned  subsidiary of AMVESCAP PLC
("AMVESCAP"),  a publicly traded holding company that, through its subsidiaries,
engages in the business of investment  management on an international  basis. As
part of  AMVESCAP,  INVESCO  draws on the  organization's  global  presence  and
expertise  to  deliver  portfolio  management  and  investment  services  to its
clients.  AMVESCAP  maintains  offices  around the world,  including  the United
States,  London,  Eastern Europe, Latin America,  Hong Kong and Tokyo.  AMVESCAP
offers a broad array of products and services to  institutions  and  individuals
through all major  distribution  channels in over 30 countries.  Recent  mergers
with  major  firms such as AIM  Management  Group Inc.  and GT Global  Inc.  and
Chancellor LGT Asset Management, Inc. (formerly the distributor of the GT Global
Funds and the asset  management  division of  Liechtenstein  Global  Trust,  AG,
respectively) have positioned AMVESCAP as one of the world's largest independent
fund management companies, adding to its already-significant presence in Europe,
Asia and  North  America.  As of March  31,  1999,  aggregate  assets  under the
management of AMVESCAP and its affiliates worldwide exceeded $___ billion. As of
that same  date,  INVESCO  managed  or  administered  assets of more than  $21.2
billion,  including 15 registered open-end investment companies with 53 separate
portfolios.  INVESCO has built a global  reputation  by  providing  professional
investment  management to some of the world's largest institutions and more than
a million  individuals.  INVESCO provides  investors with the perspective gained
from more than 65 years of helping clients pursue their financial goals.



                                       41
<PAGE>

The  Investment  Manager  determines the  composition  of the Fund's  portfolio,
places  all  orders  for the  purchase  and  sale of  securities  and for  other
transactions,  and oversees the  settlement of the Fund's  securities  and other
portfolio  transactions.  The  Investment  Manager also provides  administrative
services to the Fund. These include, among other things,  providing officers and
office space, preparing or assisting in preparing materials for shareholders and
regulatory  bodies and  overseeing  the  provision to the Fund of custodial  and
accounting services.

John  Schroer is the  portfolio  manager for the Fund.  Mr.  Schroer  joined the
Investment  Manager in 1992 and  became a Senior  Vice  President  of INVESCO in
1996. In addition to Mr. Schroer's  responsibilities as portfolio manager of the
Fund, he also manages the INVESCO  Strategic  Health  Sciences Fund. Mr. Schroer
has been an officer of the Fund since January 1996.

Mr.  Schroer  received  his B.S.  and  M.B.A.  degrees  from the  University  of
Wisconsin-Madison.  He began his investment  management  career in 1990 with the
Trust  Company of the West as an investment  analyst.  He was  eventually  given
additional  responsibilities  by the Trust Company of the West in Los Angeles as
Assistant  Vice President with  analytical  responsibilities  in the health care
industry.

INVESTMENT MANAGEMENT AGREEMENT

Under the management agreement, the Investment Manager is responsible to provide
investment  advice to the Fund and, in general,  to conduct the  management  and
investment program of the Fund under the supervision and control of the Board of
Trustees.  In addition,  the  Investment  Manager is required to furnish  office
facilities  and  equipment  to the Fund and to supply  certain  other  services,
including  all  facilities  and  personnel  necessary  to provide  the  services
required to be rendered by the Investment Manager.

On February 3, 1998, the Board of Trustees and the Investment  Manager agreed to
add a breakpoint to the investment  management  fee, such that the Fund pays the
Investment  Manager a fee based on an annual  rate of 1.00% on ending  daily net
assets up to and including $500 million, and 0.90% on ending daily net assets in
excess of $500  million.  For the fiscal year ended  October 31, 1998,  the Fund
paid  INVESCO  investment  management  fees  of  $5,556,225.   Additionally,  in
accordance  with an  Administrative  Agreement,  the Fund  pays  the  Investment
Manager a  monthly  fee based on the  annual  rate of 0.10% on ending  daily net
assets for administrative  services. For the fiscal year ended October 31, 1998,
the  Fund  paid  INVESCO  administrative  fees  of $  __________.  The  fee  for
investment management and administrative services are, in the aggregate,  higher
than those paid by most U.S. investment companies, including open-end investment
companies,  although  they  are  generally  comparable  to  those  paid by other
specialized equity, closed-end funds.

The Board of Trustees  noted that the  Investment  Manager will benefit from the
Offer  because  its fees for  investment  management  services  are based on the
average daily net assets of the Fund. It is not possible to state  precisely the
amount of  additional  compensation  the  Investment  Manager  will receive as a
result of the Offer  because it is not known how many Rights  will be  exercised
and because the proceeds of the Offer will be invested in  additional  portfolio
securities  that may  fluctuate  in value.  However,  in the event  that all the
Rights are exercised in full,  including the additional  [1/5TH TOTAL] Shares by
which the  Board,  in its  discretion,  may  increase  the  Offer,  based on the
Estimated  Subscription  Price of $______,  the Investment Manager would receive
additional fees for investment  management services of approximately $______ per
annum as a result of the increase in assets under management.


                                       42
<PAGE>

The  Chairman  of the Board of  Trustees,  Charles W. Brady,  as an  "interested
person"  of the  Fund  and of  other  funds  in the  INVESCO  complex,  receives
compensation as an officer of companies  affiliated  with INVESCO,  but does not
receive any trustee fees or other compensation from the Fund or from other funds
in the INVESCO complex for his service as a Trustee or Director.

Under the  management  agreement,  the Fund pays  certain of its other costs not
paid by the  Investment  Manager,  including  (i) interest and taxes,  including
issue and  transfer  taxes,  incurred by or levied on the Fund;  (ii)  insurance
premiums for  fidelity and other  coverage  requisite to its  operations;  (iii)
compensation  and  expenses  of its  Trustees  other  than those  associated  or
affiliated  with the  Investment  Manager;  (iv) legal and audit  expenses;  (v)
custodian, dividend paying agent, registrar and transfer agent fees and expenses
(including  charges and expenses of the Fund's  Reinvestment Plan) and brokerage
commissions,   if  any;  (vi)  certain  fees  and  expenses,   incident  to  the
registration,  under  Federal law, of the Shares for public sale;  (vii) certain
expenses  incidental  to holding  meetings  of the Fund's  shareholders;  (viii)
payments under the Fund's  administrative  services agreement with INVESCO; (ix)
fees and  expenses of listing and  maintaining  the listing of the Shares on any
national  securities  exchange;  (x) the cost of certificates  representing  the
Shares;  and (xi)  such  non-recurring  expenses  as may  arise,  including  any
litigation affecting the Fund and the legal obligation that the Fund may have to
indemnify its officers and Trustees with respect thereto.

The  management  agreement  provides  that the  Investment  Manager shall not be
liable for any error of judgment or mistake of law, or for any loss  suffered by
the Fund in  connection  with the  matters  to which  the  management  agreement
relates,  except a loss resulting from willful  misfeasance,  bad faith or gross
negligence  on the part of the  Investment  Manager  in the  performance  of its
obligations and duties or by reason of its reckless disregard of its obligations
and duties under the management agreement.

The management agreement may be terminated without penalty upon sixty (60) days'
written notice by either party, or by a vote of the majority of the Shares,  and
automatically terminates in the event of its assignment.

                                PORTFOLIO TRADING

The  Investment  Manager  places  orders for the purchase and sale of securities
with  brokers  and  dealers  based  upon  its  evaluation  of  their   financial
responsibility  subject to their  ability to effect  transactions  at  favorable
prices. The Investment Manager evaluates the overall reasonableness of brokerage
commissions and markups paid by reviewing the quality of executions  obtained on
the Fund's portfolio transactions,  viewed in terms of the size of transactions,
prevailing  market  conditions  in the security  purchased or sold,  and general
economic and market  conditions.  In seeking to ensure that the  commissions and
markups  charged  to the Fund are  consistent  with  prevailing  and  reasonable
brokerage  commissions  or markups,  the  Investment  Manager also  endeavors to
monitor brokerage  industry practices with regard to the commissions and markups
charged  by  broker/dealers  on  transactions   effected  for  other  comparable
institutional   investors.   While  the  Investment   Manager  seeks  reasonably
competitive  rates,  the Fund does not  necessarily  pay the lowest  commission,
spread or markup available.

Consistent  with the  standard  of  seeking  to  obtain  favorable execution  on
portfolio  transactions,  the Investment Manager may select brokers that provide
research  services to effect such  transactions.  Research  services  consist of
statistical and analytical reports relating to issuers,  industries,  securities
and  economic  factors and trends,  which may be of  assistance  or value to the
Investment Manager in making informed  investment  decisions.  Research services
prepared and  furnished  by brokers  through  which the Fund effects  securities


                                      43
<PAGE>



transactions  may be used by the  Investment  Manager  in  servicing  all of its
accounts  and not all such  services  may be used by the  Investment  Manager in
connection with the Fund.

In  recognition  of the  value of the  above-described  brokerage  and  research
services provided by certain brokers,  the Investment  Manager,  consistent with
the standard of seeking to obtain the best execution on portfolio  transactions,
may place orders with such brokers for the  execution  of Fund  transactions  on
which the  commissions  are in excess of those  which other  brokers  might have
charged for effecting the same transactions.

One or more of the other accounts which the Investment  Manager manages may own,
from time to time, the same  investments as the Fund.  Investment  decisions for
the Fund are made independently from those of such other accounts; however, from
time to time, the same investment decision may be made for more than one company
or  account,  including  the  Fund.  When  two or more  companies  or  accounts,
including the Fund, seek to purchase or sell the same securities, the securities
actually purchased or sold will be allocated among the companies and accounts on
a good faith  equitable  basis by the  Investment  Manager in its  discretion in
accordance with the accounts' various investment objectives. In some cases, this
system may adversely affect the price or size of the position obtainable for the
Fund. In other cases,  however, the ability of the Fund to participate in volume
transactions may produce better execution for the Fund. It is the opinion of the
Board that this advantage,  when combined with the other benefits  available due
to the Investment Manager's  organization,  outweighs any disadvantages that may
be said to exist from exposure to simultaneous transactions.
 
Transactions  in foreign  securities  markets  generally  involve the payment of
fixed  brokerage  commissions,  which are usually higher than  commission  rates
available  in the United  States.  In such  transactions,  the Fund will seek to
obtain prompt execution of orders at the most favorable net price.

                                 NET ASSET VALUE

The Fund  calculates  the NAV of its  Shares  daily and makes  that  information
available  for  publication.  Currently,  the WALL STREET  JOURNAL and  BARRON'S
publish NAVs for  closed-end  funds each week.  NAV per Share will be determined
each day on which the NYSE is open,  as of the close of trading on the NYSE that
day, and is calculated by dividing the aggregate value of all securities held by
the Fund and its other assets (including  dividends and interest accrued but not
collected) less its liabilities  (including  accrued  expenses) by the number of
outstanding  Shares. All assets and liabilities  initially  expressed in foreign
currencies  will be converted into U.S.  dollars at the mean between the bid and
offer prices of such currencies against U.S. dollars last quoted by a major bank
selected by the Fund's custodian.  Securities traded on securities exchanges are
valued at their last sale prices as of 4:00 P.M., Eastern time, on the exchanges
where  such  securities  are  primarily   traded.   Securities   traded  in  the
over-the-counter market and listed securities for which no sales are reported on
a particular  day are valued at their bid prices (or for debt  securities  yield
equivalents  thereof)  obtained from one or more dealers making markets for such
securities.  If market quotations are not readily available,  a security will be
valued at fair value as determined  in good faith by, or under the  supervision,
of the Board of Trustees.  Debt securities will be valued in accordance with the
procedures above, that may include the use of valuations  furnished by a pricing
service that employs a matrix to determine  valuations for normal  institutional
size trading units. Prior to utilizing a pricing service,  the Board of Trustees
will review the methods  used by such service to assure  itself that  securities
will  be  valued  at  their  fair  values.  The  Board  of  Trustees  also  will
periodically  monitor  the  methods  used  by any  such  pricing  service.  Debt
securities  with  remaining  maturities of 60 days or less will,  absent unusual
circumstances,  be  valued  at  amortized  cost,  so long as such  valuation  is
determined by the Board of Trustees to represent fair value.  Futures  contracts


                                      44
<PAGE>

and options thereon,  which are traded on commodities  exchanges,  are valued at
their settlement value as of the close of such commodities exchanges.

Trading in Foreign  Securities  generally is  completed,  and thus the values of
such securities are determined, prior to the close of the NYSE. Foreign currency
exchange rates are also generally  determined  prior to the primary close of the
NYSE. On occasion,  the values of such securities and such exchange rates may be
affected by events occurring between the time as of which determinations of such
values or such exchange  rates are made and the primary close of the NYSE.  When
such events  materially  affect the values of securities held by the Fund or its
liabilities,  such  securities and  liabilities  will be valued at fair value as
determined in good faith by, or under the supervision of, the Board of Trustees.

           DIVIDENDS AND OTHER DISTRIBUTIONS; DIVIDEND REINVESTMENT
                             AND CASH PURCHASE PLAN

Shareholders   who  have   Shares   registered   directly  in  their  own  names
automatically  participate in the Fund's  Reinvestment Plan, unless and until an
election  is made to withdraw  from the  Reinvestment  Plan as herein  provided.
EquiServe,  Inc.  (the  "Agent")  acts as agent under the  Reinvestment  Plan on
behalf  of  participating  shareholders.  Shareholders  who do not  wish to have
distributions automatically reinvested should so notify EquiServe, Inc. [c/o 130
Royall Street Mail Stop 45-02-62 Canton, MA 02021.  Under the Reinvestment Plan,
all  of the  Fund's  dividends  and  other  distributions  to  shareholders  are
reinvested in full and fractional  Shares as described  below. A shareholder who
owns Shares  registered in his/her  broker's or nominee  name,  and whose broker
does not provide facilities for a dividend reinvestment program, may be required
to have his/her Shares registered in his/her own name in order to participate in
the Reinvestment Plan.  Shareholders  wishing to participate in the Reinvestment
Plan whose  Shares are held in the name of a broker or  nominee  should  consult
their brokers as to how to accomplish dividend reinvestment.

The Board  has  implemented  a  Quarterly  Distribution  Policy,  which  entails
quarterly  payments of  dividends  in an amount equal to 2.5% of the Fund's NAV.
The first dividend to be paid on Shares  acquired on exercise of the Rights will
be the first  quarterly  dividend,  the record date for which  occurs  after the
issuance of the Shares.

Whenever  the Fund  declares  an  income  dividend  or a  capital  gain or other
distribution  (collectively,  "Dividends")  in  cash,  non-participants  in  the
Reinvestment  Plan will receive cash and participants in the  Reinvestment  Plan
will receive the equivalent in Shares.  Whenever the Fund declares  Dividends in
additional   unissued  but  authorized  Shares  ("Newly  Issued  Shares"),   all
shareholders (including  non-participants in the Reinvestment Plan) will receive
Newly Issued  Shares and  participants  in the  Reinvestment  Plan) will receive
Shares.   In  either  instance,   the  Shares  received  by  Reinvestment   Plan
participants  will be  acquired  by the  Agent  for the  participant's  account,
depending upon the circumstances  described below, either (i) through receipt of
Newly Issued  Shares or (ii) by the purchase of  outstanding  Shares on the open
market ("Open-Market Purchases") on the NYSE or elsewhere. Open-Market Purchases
will be made only if the Fund declares a Dividend payable only in cash.

If, on the payment  date for a  Dividend,  the NAV per Share is equal to or less
than the  market  price per Share plus  estimated  brokerage  commissions  (such
condition being referred to herein as "Market Premium"), the Agent will purchase
Newly Issued Shares from the Fund on behalf of the Reinvestment Plan participant
at a price per  Share  equal to the  greater  of the NAV per Share or 95% of the


                                       45
<PAGE>


then current market price per Share. This discount from the current market price
reflects  savings in underwriting  and other costs that the Fund would otherwise
incur to raise additional capital.

If, on the payment  date for a Dividend,  the NAV per Share is greater  than the
market  price per Share  (such  condition  being  referred  to herein as "Market
Discount"),  the Agent will  endeavor  to invest the  Dividend  amount in Shares
acquired on behalf of the participants in Open-Market Purchases. In the event of
a Market  Discount on the payment date,  the Agent will have up to 30 days after
the payment date to invest the Dividend amount in Shares acquired in Open-Market
Purchases.

Registered shareholders who acquire their Shares in open-market transactions and
who do not wish to have  their  Dividends  automatically  reinvested  should  so
notify the Fund in  writing.  If a  shareholder  has not  previously  elected to
receive cash  Dividends and the Agent does not receive  notice of an election to
receive cash Dividends prior to the record date of any Dividend, the shareholder
will automatically receive such Dividends in additional Shares.

Participants in the Reinvestment Plan may withdraw from the Reinvestment Plan by
providing  written  notice to the Agent at least 30 days prior to the applicable
Dividend payment date. When a participant  withdraws from the Reinvestment Plan,
or upon termination of the Reinvestment Plan as provided below, certificates for
whole Shares credited to his/her account under the Reinvestment  Plan will, upon
request, be issued.  Whether or not a participant requests that certificates for
whole Shares be issued,  a cash payment will be made for any fraction of a Share
credited to such account.

The Agent will maintain all shareholder  accounts in the  Reinvestment  Plan and
furnish written  confirmations  of all  transactions in the accounts,  including
information  needed by shareholders for personal and tax records.  Shares in the
account  of each  Reinvestment  Plan  participant  will be held by the  Agent in
non-certificated  form in the name of the  participant,  and each  shareholder's
proxy will include those Shares  purchased  pursuant to the  Reinvestment  Plan.
Each participant,  nevertheless, has the right to receive certificates for whole
Shares owned.  The Agent will  distribute  all proxy  solicitation  materials to
participating shareholders.

In the case of  shareholders,  such as banks,  brokers  or  nominees,  that hold
Shares  for  others  who  are  the  beneficial   owners   participating  in  the
Reinvestment  Plan, the Agent will administer the Reinvestment Plan on the basis
of the number of Shares certified from time to time by the record shareholder as
representing the total amount of Shares registered in the shareholder's name and
held for the account of  beneficial  owners  participating  in the  Reinvestment
Plan.

There will be no charge to  participants  for  reinvesting  Dividends other than
their share of brokerage  commissions as discussed  below.  The Agent's fees for
administering  the Reinvestment  Plan and handling the reinvestment of Dividends
will be paid by the Fund. Each participant's  account will be charged a PRO-RATA
share of brokerage  commissions incurred with respect to the Agent's Open-Market
Purchases in connection with the  reinvestment of Dividends.  Brokerage  charges
for  purchasing  small  amounts of Shares for  individual  accounts  through the
Reinvestment  Plan are expected to be less than the usual brokerage  charges for
such  transactions  because  the Agent  will be  purchasing  Shares  for all the
participants  in  blocks  and  prorating  the  lower   commission  that  may  be
attainable.

The automatic  reinvestment  of Dividends will not relieve  participants  of any
income  tax that  may be  payable  on such  Dividends.  In the case of  non-U.S.
participants  whose  Dividends are subject to U.S. income tax withholding and in
the case of any  participants  subject to 31% federal  backup  withholding,  the
Agent will  reinvest  Dividends  after  deduction  of the amount  required to be
withheld.


                                       46
<PAGE>

The Fund  reserves  the right to amend or  terminate  the  Reinvestment  Plan by
written notice to participants.  All correspondence  concerning the Reinvestment
Plan should be  directed  to the Agent at the  address  referred to in the first
paragraph of this section.

              FEDERAL TAXATION OF THE FUND AND ITS SHAREHOLDERS

The following information is a brief, general summary for U.S. taxpayers. Please
see the SAI for additional  information.  Shareholders  should rely on their own
tax  advisors  for  advice  about the  particular  federal,  state and local tax
consequences of investing in the Fund.

The Fund  intends to operate so that it will not have to pay  federal  income or
excise tax; failure to do so would adversely affect its investment performance.

The Fund will distribute all or substantially  all of its net investment  income
and capital gains to its shareholders every year.  Shareholders will be taxed on
distributions  they  receive,  regardless  of  whether  they are paid in cash or
reinvested in Shares.  If the Fund declares a distribution in October,  November
or December of one year to  shareholders  of record in that year, but pays it in
January of the following year, shareholders will be taxed on the distribution as
if it was received on December 31 of the year in which it was declared.

The Fund will send shareholders a tax report each year, before February 1st. The
report will  designate the amount of dividends  that must be treated as ordinary
income  and  the  amount,   if  any,  that  must  be  treated  as  capital  gain
distributions.  If  the  Fund  designates  a  distribution  as  a  capital  gain
distribution,  shareholders  will be liable  for tax  thereon  at the  long-term
capital gains tax rate, no matter how long they held their Shares.

If a  shareholder  holds  Shares  in a  Retirement  Plan,  such as an  IRA,  the
shareholder  generally will not have to pay tax on Fund distributions until they
are distributed to the shareholder  from the Retirement  Plan.  Retirement Plans
are subject to complex tax rules,  and  shareholders  should  consult  their tax
advisors about investing in Shares through a Retirement Plan.

A  shareholder  generally  will have a capital gain or loss on a sale of Shares.
The amount of the gain or loss and the rate of tax will depend  primarily on how
much the shareholder paid for the Shares, how much the shareholder sold them for
and how long the Shares were held.

Like all taxpayers,  the Fund may be required to withhold  federal income tax at
the  rate  of  31%  of all  distributions  payable  to an  individual  or  other
non-corporate  shareholder who fails to provide the Fund with a correct taxpayer
identification  number  or  fails  to make  required  certifications,  or if the
shareholder  has been  notified  by the IRS that he or she is  subject to backup
withholding.  Backup  withholding is not an additional tax. Any amounts withheld
may be credited against a shareholder's federal income tax liability.

                 DESCRIPTION OF SHARES OF BENEFICIAL INTEREST

GENERAL

The Board of Trustees of the Fund has authority to issue an unlimited  number of
Shares,  $0.01 par value.  The Shares  outstanding are, and those offered hereby
when issued will be, fully paid and  nonassessable  by the Fund. The Shares have
no preemptive,  conversion,  exchange or redemption  rights.  Each Share has one
vote,  with  fractional  Shares  voting   proportionately.   Shares  are  freely



                                       47
<PAGE>

transferable,  and holders  thereof are entitled to dividends as declared by the
Board of Trustees. If the Fund were liquidated, shareholders would receive their
PRO-RATA  portion of its net assets.  Under the rules of the NYSE  applicable to
listed  companies,  the Fund  will be  required  to hold an  annual  meeting  of
shareholders in each year. If the Fund were converted to an open-end  investment
company or, if for any other reason the Shares are no longer  listed on the NYSE
(or any other  national  securities  exchange the rules of which require  annual
meetings of  shareholders),  the Fund does not intend to hold annual meetings of
shareholders.

Under  Massachusetts law,  shareholders could, under certain  circumstances,  be
held personally liable for the obligations of the Fund. However, the Declaration
of Trust disclaims shareholder liability for acts or obligations of the Fund and
requires that notice of such  disclaimer be given in each agreement  obligation,
or instrument entered into or executed by the Fund or the Board of Trustees. The
Declaration of Trust provides for  indemnification  out of Fund property for all
loss and expense of any shareholder  held personally  liable for the obligations
of the Fund. Thus, the risk of a shareholder incurring financial loss on account
of shareholder  liability is limited to circumstances in which the Fund would be
unable to meet its obligations. The likelihood of such circumstances is remote.

The Fund has no present  intention  of offering  additional  Shares,  other than
under this Offering and under the  Reinvestment  Plan.  See "Dividends and Other
Distributions; Dividend Reinvestment and Cash Purchase Plan." Other offerings of
Shares, if made, will require approval of the Board of Trustees.  Any additional
offering will be subject to the requirements of the 1940 Act that Shares may not
be sold at a price  below  the  then  current  NAV,  exclusive  of  underwriting
discounts and  commissions,  except in  connection  with an offering to existing
shareholders  or with the  consent of the  holders  of a majority  of the Fund's
outstanding  Shares.  In addition,  the Fund  expects  that it would  commence a
continuous  offering  of its  Shares in the event it  converted  to an  open-end
investment company. See "Conversion to Open-End Status."

The Declaration of Trust further  provides that  obligations of the Fund are not
binding  upon the Trustees  individually  but only upon the property of the Fund
and that the Board of  Trustees  will not be liable  for errors of  judgment  or
mistakes of fact or law,  but  nothing in the  Declaration  of Trust  protects a
Trustee against any liability to which the Trustee would otherwise be subject by
reason of willful misfeasance, bad faith, gross negligence or reckless disregard
of the duties involved in the conduct of office.

CERTAIN ANTI-TAKEOVER PROVISIONS OF THE DECLARATION OF TRUST AND BY-LAWS

The Fund's Declaration of Trust and By-laws (together,  the "Charter Documents")
could have the effect of limiting:  (i) the ability of other entities or persons
to  acquire  control of the Fund;  (ii) the Fund's  freedom to engage in certain
transactions;  or  (iii)  the  ability  of  the  Fund's  Board  of  Trustees  or
shareholders  to amend the  Charter  Documents  or effect  changes in the Fund's
management.  Those  provisions  of the  Charter  Documents  may be  regarded  as
"anti-takeover"  provisions.  Commencing with the first meeting of shareholders,
the Board of Trustees  was  divided  into three  classes,  each having a term of
three years. At the annual meeting of shareholders in each year thereafter,  the
term of one class of Trustees expires.  Accordingly,  only those Trustees in one
class may be changed in any one year,  and up to three  years may be required to
replace a majority of the Board.  Such system of electing  Trustees may have the
effect of maintaining the continuity of management. Under the Fund's Declaration
of Trust,  the  affirmative  vote of the holders of not less than two-thirds (66
2/3%) of the Fund's outstanding Shares entitled to vote is required to authorize
the  consolidation of the Fund with another entity, a merger of the Fund with or
into  another  entity  (except  for  certain  mergers  in which  the Fund is the


                                      48
<PAGE>


successor), a sale or transfer of all or substantially all of the Fund's assets,
the  termination  of the  Fund,  the  conversion  of  the  Fund  to an  open-end
investment  company,  and any amendment to the Fund's  Declaration of Trust that
would affect any of the other provisions requiring a two-thirds vote. However, a
"Majority  Shareholder  Vote," as defined  in the  Charter  Documents,  shall be
sufficient  to  approve  any  of  the  foregoing  transactions  that  have  been
recommended by two-thirds of the Trustees.  Notwithstanding the foregoing,  if a
corporation, person or entity is directly, or indirectly through its affiliates,
the  beneficial  owner of more  than 5% of the  outstanding  Shares of the Fund,
("Principal Shareholder") the affirmative vote of 80% (which is higher than that
required under the 1940 Act) of the outstanding  Shares is required generally to
authorize any of the following  transactions  or to amend the  provisions of the
Declaration of Trust relating to transactions involving:

            (i)   a merger or consolidation of the Fund  with  or  into
            any such Principal Shareholder;

            (ii)  the  issuance  of  any  securities of the Fund to any
            such Principal Shareholder for cash;

            (iii) the sale, lease or exchange of all or any substantial
            part  of the  assets  of the  Fund  to any  such  Principal
            Shareholder (except assets having an aggregate market value
            of less than $1,000,000);

            (iv)  the sale, lease or exchange to the Fund,  in exchange
            for  securities  of the  Fund,  of any  assets  of any such
            Principal  Shareholder  (except  assets having an aggregate
            fair market value of less than $1,000,000);
 
            (v)   the liquidation or termination of the Fund;

            (vi)  a change in the nature of the business of the Fund so
            that it would cease to be an investment  company registered
            under 1940 Act; or

            (vii) the conversion of the Fund to an "open-end  company,"
            or any  amendment to the  Declaration  of Trust of the Fund
            that  makes the  Shares a  "redeemable  security,"  as such
            terms are defined in the 1940 Act.

If two-thirds of the Board has approved a memorandum of understanding  with such
beneficial  owner,  however,  a  majority  shareholder  vote,  as defined in the
Charter  Documents,  will be sufficient  to approve the foregoing  transactions.
Reference is made to the Charter  Documents  of the Fund,  on file with the SEC,
for the full text of these provisions.

The overall effect of the provisions of the Charter Documents described above is
to render more  difficult the  accomplishment  of a merger or the  assumption of
control by a shareholder  or another entity or person and to make the removal of
management  more  difficult  than if such  provisions  were not in place.  These
provisions  may be beneficial  to  management in a hostile  tender offer for the
Shares  and  may  have  an  adverse  impact  on  shareholders  who  may  want to
participate in such a tender offer. In particular, they could have the effect of
depriving shareholders of the opportunity to sell their Shares at a premium over
prevailing  market prices by  discouraging  a third party from seeking to obtain
control of the Fund in a tender offer or similar  transaction.  Moreover,  these
provisions would apply to actions proposed by anyone, including management,  and
would make changes in the Fund's  structure  accomplished  through a transaction
covered by the provisions more difficult to achieve. The provisions may give the



                                       49
<PAGE>


holders of a minority of the Shares  entitled to vote a veto power over a merger
that  management  and a  majority  of the  Fund's  shareholders  may  believe is
desirable and beneficial.

In the  opinion of the  Board,  however,  the  anti-takeover  provisions  of the
Charter Documents provide the advantage of potentially requiring persons seeking
control of the Fund to negotiate with its management  regarding price to be paid
and facilitating the continuity of the Fund's management,  investment  objective
and policies.  The Board has considered the foregoing  anti-takeover  provisions
and  concluded  that  they  are in  the  best  interests  of the  Fund  and  its
shareholders.  The above  description is subject to the provisions  contained in
the Charter Documents.

REPURCHASE OF SHARES

Shares of closed-end  funds  frequently trade at a discount from NAV but in some
cases trade at a premium.  In  recognition  of the  possibility  that the Shares
might similarly trade at a discount, the Fund's Board of Trustees has determined
that it would be in the interest of shareholders  for the Fund to take action to
attempt to reduce or  eliminate a market value  discount  from NAV. To that end,
the Board of  Trustees  recognizes  that the Fund might from  time to time  take
action either to  repurchase  its Shares in the open market or to tender for its
own Shares at NAV. The Board of Trustees,  in  consultation  with the Investment
Manager, reviews on a quarterly basis the possibility of open market repurchases
and/or  tender  offers for  Shares.  There are no  assurances  that the Board of
Trustees  will,  in fact,  decide to  undertake  either of these  actions or, if
undertaken, that such actions will result in the Shares trading at a price which
is equal to or approximates  their NAV. In addition,  the Board of Trustees will
not necessarily  announce when it has given consideration to these matters.  See
"Repurchase of Shares" in the SAI for further information.

CONVERSION TO OPEN-END STATUS

The Fund's  Declaration  of Trust provides that the Fund may be converted at any
time from a "closed-end  company" to an "open-end  company" upon the approval of
the holders of not less than two-thirds (66 2/3%) of the Shares  outstanding and
entitled to vote. If a corporation,  person or entity is directly, or indirectly
through its affiliates,  the beneficial owner of more than 5% of the outstanding
Shares,  the  affirmative  vote of 80% (which is higher than that required under
the  1940  Act) of the  outstanding  Shares  is  required  to  authorize  such a
conversion.  Shareholders  of an  open-end  investment  company  may require the
company to redeem their shares at any time (except in certain  circumstances  as
authorized by or under the 1940 Act) at their NAV, less  redemption  charge,  if
any, as might be in effect at the time of redemption.  The  Declaration of Trust
of the Fund provides that from time to time the Board will consider recommending
to the  shareholders  a proposal  to convert  the Fund from a  closed-end  to an
open-end  investment  company.  The Board may, however,  determine that the Fund
should not take any action to convert the Fund to an open-end investment company
or that, due to the characteristics of the Fund's portfolio  securities,  it may
be inappropriate to convert the Fund to an open-end investment company.

                       CUSTODIAN, TRANSFER AGENT, DIVIDEND
                         DISBURSING AGENT, AND REGISTRAR

The Fund's  securities  and cash are held under a custodian  agreement  by State
Street  Bank and  Trust  Company  ("State  Street"),  whose  principal  place of
business is 225 Franklin Street, Boston,  Massachusetts,  02110. With respect to
the Fund's  investments in Foreign  Securities,  the custodian  employs  foreign
subcustodians  approved by the Board of Trustees in accordance  with  applicable


                                       50
<PAGE>


regulations after  consideration of, among other things,  the  qualifications of
proposed foreign  subcustodians  and the legal  constraints  under which foreign
subcustodians operate. State Street also serves as transfer agent, registrar and
dividend disbursing agent for the Shares.  Pursuant to a services agreement with
EquiServe,  Inc., an affiliate of State Street,  serves as  Shareholder  Service
Agent  for the Fund  and,  as such,  performs  all of State  Street's  duties as
transfer agent and dividend-paying agent.

                                  LEGAL MATTERS

Kirkpatrick & Lockhart LLP, Washington,  D.C., serves as counsel to the Fund and
to the  Independent  Trustees and as special counsel to the Fund with respect to
the Offer and will pass on the legality of the Shares  offered  hereby.  Certain
legal matters will be passed on for the Dealer Manager by Skadden,  Arps, Slate,
Meagher & Flom (Illinois) and its affiliated entities.

                             REPORTS TO SHAREHOLDERS

The  Fund  will  send  unaudited  semi-annual  and  audited  annual  reports  to
shareholders, including a list of the portfolio investments held by the Fund.

                             INDEPENDENT ACCOUNTANTS

The data in the "Financial Highlights" section of this Prospectus are based upon
financial  statements  that have been  audited  by  PricewaterhouseCoopers  LLP,
independent  public  accountants,  as  indicated  in their  reports with respect
thereto, and are included in reliance upon the authority of said firm as experts
in auditing and accounting.


                               FURTHER INFORMATION

This  Prospectus  does  not  contain  all of the  information  set  forth in the
Registration  Statement  that the  Fund has  filed  with the SEC.  The  complete
Registration  Statement  may be  obtained  from the SEC upon  payment of the fee
prescribed by its Rules and Regulations.



                                       51
<PAGE>

            TABLE OF CONTENTS OF STATEMENT OF ADDITIONAL INFORMATION

ITEM No.   CAPTION                                              LOCATION IN SAI
- --------   -------                                              ---------------

14.        General Information

15.        Additional Information About Its Investment
           Objective and Policies

16.        Investment Restrictions

17.        Management

18.        Ownership of Fund Shares

19.        Portfolio Transactions

20.        Repurchase of Shares and Tender Offers

21.        Taxation

22.        Financial Statements




                                       52
<PAGE>

- ----------------------------------------        --------------------------------
- ----------------------------------------        --------------------------------
No one has been  authorized  to give any
information     or    to    make     any
representations    other    than   those
contained   in   this    Prospectus   in
connection  with  this  Offer.  If other
information    is    given    or   other          ________ SHARES OF BENEFICIAL 
representations     are    made,    such                    INTEREST            
information or representations  must not                                        
be  relied   upon  since   neither   was                 INVESCO GLOBAL         
authorized by the Fund,  the  Investment                     HEALTH             
Manager  or  the  Dealer  Manager.  This                  SCIENCES FUND         
Prospectus  does not constitute an offer        ISSUABLE UPON EXERCISE OF RIGHTS
to sell or the solicitation of any offer              TO SUBSCRIBE FOR SUCH     
to  buy  any  security  other  than  the          SHARES OF BENEFICIAL INTEREST 
Fund's  Shares,  as  described  in  this                                        
Prospectus.  This  Prospectus  also does                                        
not  constitute  an  offer  to sell or a           __________________________   
solicitation  of any  offer  to buy  the                                        
Fund's  Shares,  as  described  in  this                   PROSPECTUS           
Prospectus,  by  anyone  in any state in           __________________________   
which such offer or  solicitation is not        
authorized,   or  in  which  the  person
making such offer or solicitation is not
qualified  to  do  so,  or to  any  such                  DEALER MANAGER      
person  to  whom it is  illegal  to make                                      
such   offer   or   solicitation.    The             PAINEWEBBER INCORPORATED 
information  in this  Prospectus  may no         
longer be correct  after the date on the
Prospectus.  However,  if  any  material             [EFFECTIVE DATE], 1999
change occurs during the period in which
this  Prospectus is legally  required to
be  delivered,  the  Prospectus  will be
amended  or  supplemented   accordingly.
      ----------------------

         TABLE OF CONTENTS                        

                                    PAGE
Prospectus Summary ...................
Fee Table ............................
Financial Highlights .................
The Fund .............................
Use of Proceeds ......................
Investment Objective and Policies
Investment Restrictions ..............
Risk Factors and Special
Considerations .......................
Management of the Fund ...............
Portfolio Trading ....................
Net Asset Value ......................
Dividends and Other Distributions:
  Dividend Reinvestment and Cash
  Purchase Plan ......................
Federal Taxation Of The Fund And Its
  Shareholders........................
Description of Shares of Beneficial
  Interest............................
Custodian, Transfer Agent, Dividend
  Disbursing Agent, and Registrar
Legal Matters ........................
Independent Accountants ..............


- ----------------------------------------        --------------------------------
- ----------------------------------------        --------------------------------
                                       53

<PAGE>


                              SUBJECT TO COMPLETION
                             [EFFECTIVE DATE], 1999.

[INVESCO FUND LOGO]

                       INVESCO GLOBAL HEALTH SCIENCES FUND

                       STATEMENT OF ADDITIONAL INFORMATION

This SAI is not a prospectus but should be read in  conjunction  with the Fund's
Prospectus  dated  [EFFECTIVE  DATE],  1999.  This  SAI  does  not  include  all
information  that a  prospective  investor  should  consider  before  purchasing
Shares,  and investors should obtain and read the Prospectus prior to purchasing
Shares. A copy of the Prospectus may be obtained without charge,  by calling the
Fund at 1-800-528-8765 or by contacting the Fund at 7800 E. Union Avenue,  Suite
800,  Denver,  Colorado  80237.  This SAI  incorporates  by reference the entire
Prospectus.

The  Prospectus  and this SAI omit certain of the  information  contained in the
registration  statement  filed by the Fund with the SEC,  Washington,  D.C. That
registration  statement  may be  obtained  from the SEC upon  payment of the fee
prescribed or inspected at the SEC's office at no charge.  Capitalized terms not
defined herein have the meanings attributed to them in the Prospectus.

INFORMATION   CONTAINED  HEREIN  IS  SUBJECT  TO  COMPLETION  OR  AMENDMENT.   A
REGISTRATION STATEMENT RELATING TO THESE SECURITIES HAS BEEN FILED WITH THE SEC.
THESE  SECURITIES MAY NOT BE SOLD NOR MAY ANY OFFERS TO BUY BE ACCEPTED PRIOR TO
THE TIME  THE  REGISTRATION  STATEMENT  BECOMES  EFFECTIVE.  THIS  STATEMENT  OF
ADDITIONAL INFORMATION DOES NOT CONSTITUTE A PROSPECTUS.



<PAGE>
            TABLE OF CONTENTS OF STATEMENT OF ADDITIONAL INFORMATION

ITEM No.   CAPTION                                              LOCATION IN SAI
- --------   -------                                              ---------------

14.        General Information

15.        Additional Information About Its Investment
           Objective and Policies

16.        Investment Restrictions

17.        Management

18.        Ownership of Fund Shares

19.        Portfolio Transactions

20.        Repurchase of Shares and Tender Offers

21.        Taxation

22.        Financial Statements



                                       2
<PAGE>


                               GENERAL INFORMATION

INVESCO Global Health  Sciences Fund is a diversified,  closed-end  management
investment company under the Investment  Company Act of 1940, as amended.  The
Fund's investment manager is INVESCO Funds Group, Inc.

                 ADDITIONAL INFORMATION ABOUT ITS INVESTMENT
                             OBJECTIVE AND POLICIES

The Fund's  investment  objective is  to seek capital  appreciation by investing
substantially  all of its assets in equity and related  securities  of U.S.  and
foreign Health Science Companies.  The Fund is aggressively  managed for growth.
The Fund seeks to achieve its objective by investing its assets in a broad range
of health care related equity securities, such as market-leading  pharmaceutical
companies,  medical  devices  manufacturers  and suppliers,  and various private
placement investments.

Some of the different types of securities in which the Fund may invest,  subject
to its investment objective,  policies,  and restrictions,  are described in the
Prospectus  under  "Investment  Objective and Policies" and "Special  Investment
Practices."  Additional information concerning certain of the Fund's investments
and investment techniques is set forth below.

HEDGING -FUTURES AND OPTIONS TRANSACTIONS

GENERAL.  The Fund may engage in futures and options  transactions in accordance
with its investment  objective and policies.  The Fund intends to engage in such
transactions if it appears  advantageous  to the Investment  Manager to do so in
order to pursue its investment objective, to hedge against the effects of market
conditions  and to  stabilize  the value of its  assets.  The use of futures and
options,  possible benefits and attendant risks are discussed below,  along with
information concerning certain other investment policies and techniques.

OPTIONS ON SECURITIES.  The Fund is authorized to write covered call options and
secured put options and to purchase  put and call options on the  securities  in
which it may invest that are listed on domestic  exchanges  or on the  quotation
system operated by the National Association of Securities Dealers, Inc. ("listed
options"),  or that are privately  negotiated in  over-the-counter  transactions
("OTC  options").  OTC  options,  other than those  discussed  in the  following
sentence,  are deemed to be illiquid securities and are,  therefore,  subject to
the Fund's  limitation that a maximum of 25% of its total assets may be invested
in illiquid securities.  The Fund may engage in OTC options transactions on U.S.
Government  Securities with U.S. Government Securities dealers recognized by the
Federal  Reserve Bank of New York  subject to a forward  price at which the Fund
has the absolute  right to repurchase the OTC option which it has sold, in which
case the value of such OTC option purchased will not be considered illiquid.  In
OTC  options  transactions  with other  dealers or without  such  pre-negotiated
forward  repurchase  prices,  OTC options  purchased and the Fund assets used to
"cover" OTC options sold by the Fund will be  considered  "illiquid  securities"
and will be subject to the Fund's  limitation that a maximum of 25% of its total
assets may be  invested  in  illiquid  securities.  The  "formula"  on which the
forward  price will be based may vary among  contracts  with  different  primary
dealers,  although  generally  it will be based  on a  multiple  of the  premium
received by the Fund for  writing  the option  plus the  amount,  if any, of the
option's   intrinsic  value,  I.E.,  current  market  value  of  the  underlying
securities  minus the  option's  strike  price.  Listed  options are issued by a
clearing corporation, the Options Clearing Corporation ("OCC").

                                       3

<PAGE>

By purchasing a listed call option on a security, the Fund will obtain the right
to buy the securities underlying the option from the OCC at a specified exercise
price prior to or at the expiration of the option.  By selling (writing) such an
option,  the Fund will obligate  itself to sell the  securities  underlying  the
option to the OCC at the specified  exercise price prior to or at the expiration
if it is  assigned  an  exercise  notice.  A listed  put  option  on a  security
purchased by the Fund gives the Fund the right to sell the securities underlying
the option to the OCC at the exercise  price prior to or at the  expiration.  By
selling  (writing)  such  an  option,  the  Fund  obligates  itself  to buy  the
securities  underlying the option from the OCC at the exercise price prior to or
at the expiration if it is assigned an exercise notice.

OTC options operate in a similar manner but are purchased from or sold (written)
to dealers or financial institutions which enter into direct agreements with the
Fund. While listed options have "standardized" exercise prices, expiration dates
and other  features,  the features of OTC options can vary as agreed upon by the
Fund and by the other party to the option and there is no  intermediation of the
OCC.

The Fund may purchase call options to protect against  increases in the costs of
securities proposed to be acquired or to terminate ("close out") existing option
positions.  Put options may be purchased to seek to protect against  declines in
the  value of  securities  which  are held (or  which  the Fund has the right to
acquire) or to close out existing  option  positions.  When put and call options
are sold (written) by the Fund, the Fund receives  premiums as the writer of the
options,  which provide a partial hedge against adverse  movements in the prices
of the underlying  securities.  The income received from premiums will fluctuate
with varying economic market conditions.  Calls may also be written to close out
existing  option  positions.  Put options  may also be sold when the  Investment
Manager  wishes to purchase a security at a price lower than its current  market
price.  Call  options  written by the Fund must be  "covered."  A call option is
covered if the Fund owns or has the right to acquire the  securities  underlying
the option.  A call option is also  covered if the Fund holds a call on the same
security as the underlying  security of the written  option,  where the exercise
price of the call used for coverage is equal to or less than the exercise  price
of the call written or, if the  exercise  price of the call used for coverage is
greater than the exercise price of the call written,  by maintaining the mark to
market  difference in cash,  U.S.  Government  Securities or other liquid,  high
quality  short-term  debt  obligations  in a segregated  account with the Fund's
custodian.

In the  case of  listed  options  and  certain  OTC  options,  during  or at the
termination  of the option  period,  the Fund may be required,  at any time,  to
deliver the  underlying  security  against  payment of the exercise price on any
calls it has written.  Exercise of certain listed options and OTC options may be
limited to  specific  expiration  dates.  This  obligation  terminates  upon the
expiration of the option period.  The obligation can be terminated at an earlier
time by effecting a closing purchase transaction. A closing purchase transaction
is  accomplished  by  purchasing  an  option of the same  series  as the  option
previously written.  However, once assigned an exercise notice with respect to a
listed option, the Fund will be unable to effect a closing purchase transaction.

Closing purchases transactions are ordinarily effected to realize a profit on an
outstanding call option, to prevent an underlying security from being called, to
permit the sale of an  underlying  security or to enable  another call option on
the underlying  security  (with either a different  exercise price or expiration
date or both) to be written. Also, effecting a closing purchase transaction will
permit the cash or proceeds from the concurrent  sale of any securities  subject
to the option to be used for other investments.  The Fund may realize a net gain
or loss from a closing purchase transaction depending upon whether the amount of
the  premium  received  on the  call  option  is more or less  than  the cost of
effecting  the  closing  purchase  transaction.  Any loss  incurred in a closing
purchasing   transaction  may  be  wholly  or  partially  offset  by  unrealized


                                       4

<PAGE>

appreciation in the market value of the underlying security.  Conversely, a gain
resulting  from a closing  purchase  transaction  could be offset in whole or in
part or exceeded by a decline in the market value of the underlying security.

If a call option  written by the Fund expires  unexercised,  the Fund realizes a
gain in the amount of the premium on the option less the commission paid. Such a
gain,  however,  may be  offset  by  depreciation  in the  market  value  of the
underlying  security  during the option period.  If a call option written by the
Fund is  exercised,  it realizes a gain or loss from the sale of the  underlying
security  equal to the  difference  between the purchase price of the underlying
security and the proceeds of the sale of the security plus the premium  received
on the option less the commission paid.

Options written by the Fund normally have expiration  dates of up to nine months
from the date written.  The exercise price of a call option may be below,  equal
to or above the current market value of the underlying  security at the time the
option is written.

As a writer of a secured put option on securities, the Fund incurs an obligation
to buy the security  underlying the option from the purchaser of the put, at the
option's  exercise price at any time during, or at the expiration of, the option
period (certain listed and OTC put-options  will be exercisable by the purchaser
only on a specific  date).  A put is  "secured" if the Fund  maintains  with its
custodian in a segregated  account  cash,  U.S.  Government  Securities or other
liquid,  high quality short-term debt obligations in an amount equal to at least
the exercise price of the option.  Similarly, a put position could be covered by
purchase of a put option on the same  underlying  security,  where the  exercise
price of the option purchased is equal to or more than the exercise price of the
put  written or less than the  exercise  price of the put written if the mark to
market  difference is maintained in cash. In writing puts,  the Fund assumes the
risk of loss should the market value of the  underlying  security  decline below
the exercise price of the option (any loss being decreased by the receipt of the
premium on the option written).  The operation of and limitations on secured put
options in other respects are substantially identical to those of call options.

The Fund will  write put  options to obtain  income  from the  premiums  paid by
purchasers which provide a partial hedge. Puts may also be written when the Fund
wishes to purchase  securities at prices lower than their current market prices,
in which case the Fund will write the put at an exercise  price  reflecting  the
lower  purchase  price  sought.  The  potential  gain on a secured put option is
limited to the premium  received on the option (less the commissions paid on the
transaction) while the potential loss equals the difference between the exercise
price of the option and the current market price of the underlying securities at
the  time  the put is  exercised,  offset  by the  premium  received  (less  the
commissions  paid on the  transaction).  Puts may also be  written  to close out
existing option positions.

The Fund may purchase put options on securities which it holds (or has the right
to acquire) to protect against a decline in the value of its securities.  If the
value  of the  underlying  securities  were in such a case  to  fall  below  the
exercise  price of the put purchased in an amount  greater than the premium paid
for the  option,  the Fund would  incur no  additional  loss.  The Fund may also
purchase put options to close out written put  positions in a manner  similar to
call options closing  purchase  transactions.  Such a sale would result in a net
gain or loss  depending  on whether  the amount  received on the sale is more or
less than the premium and other  transaction  costs paid on the put option which
is sold.  If a put option  purchased by the Fund expires  without  being sold or
exercised, the premium will be lost.

During the option  period,  a covered call writer has, in return for the premium
on the  option,  given up the  opportunity  for capital  appreciation  above the
exercise price should the market price of the underlying security increase,  but
has  retained  the risk of loss  should  the  price of the  underlying  security
decline.  A secured put writer  also  retains the risk of loss should the market


                                       5
<PAGE>

value of the underlying  security decline below the exercise price of the option
less the premium  received on the sale of the option.  In both cases, the writer
has no control  over the  exercise  of the option and may be required to fulfill
its obligation as a writer of the option.  Once an option writer has received an
exercise  notice with  respect to a listed  option,  it cannot  effect a closing
purchase  transaction in order to terminate its obligation  under the option and
must deliver or receive the underlying  securities at the exercise price.

Prior to exercise or  expiration,  an option  position can only be terminated by
entering into a closing purchase or sale  transaction.  If a covered call option
writer is unable to effect a closing transaction or enter into an offsetting OTC
option,  it cannot sell the underlying  security until the option expires or the
option  is  exercised  or the Fund  provides  an  alternative  means  of  cover.
Accordingly,  a covered call option writer may not be able to sell an underlying
security at a time when it might  otherwise be  advantageous to do so. A secured
put option writer who is unable to effect a closing transaction or an offsetting
OTC option would continue to bear the risk of decline in the market price of the
underlying security until the option expires or is exercised. In addition, a put
writer would be unable to utilize the amounts  securing the put option until the
exercise or expiration of the option.

The  Fund's  ability  to close  out its  position  as a writer  of an  option is
dependent upon the existence of a liquid secondary market. There is no assurance
that such a market will exist,  particularly in the case of OTC options, as such
options will generally only be closed out by entering into a closing transaction
with a dealer.  However, the Fund may be able to purchase or write an offsetting
option  which does not close out its  position  as a writer but  constitutes  an
asset  offsetting the risks of the obligation  under the option written.  If the
Fund is not able to enter into a closing transaction or an offsetting  position,
it will be required  to  maintain  the  securities  subject to the call,  or the
collateral  underlying the put, even though it might not be  advantageous  to do
so, until a closing  transaction can be entered into (or the option is exercised
or expires).

The  possible  reasons for the absence of a liquid  secondary  market for listed
options  include:  (i) insufficient  trading  interest in certain options;  (ii)
restrictions  on  transactions  imposed  by  exchanges;   (iii)  trading  halts,
suspensions or other restrictions  imposed with respect to particular classes or
series of options or  underlying  securities;  (iv)  interruption  of the normal
operations on an exchange;  (v)  inadequacy of the  facilities of an exchange or
the OCC to handle  current  trading  volume;  or (vi) a decision  by one or more
exchanges to discontinue the trading of options (or a particular class or series
of options),  in which event the  secondary  market on that exchange (or in that
class or series of options) would cease to exist,  although  outstanding options
on that  exchange  that had been issued by the OCC as a result of trades on that
exchange would  generally  continue to be  exercisable in accordance  with their
terms.  The inability to close out options  positions could also have an adverse
impact on the ability of the Fund to hedge its  positions.  In addition,  in the
event of the  bankruptcy  of a broker  through which the Fund engages in options
transactions, particularly a broker who sold an OTC option to the Fund, the Fund
could  experience  delays or losses in liquidating  open positions  purchased or
sold through such brokers or loss of all or part of the value of the options. It
should  also be noted that  exchanges  have  limitations  governing  the maximum
number of options of a particular type that may be written by a single investor.
Positions in excess of these limitations may be required to be liquidated. These
positions  limits may  operate  to  restrict  the number of options  that may be
written by the Fund.

The hours of trading for options may not conform to the hours  during  which the
underlying  securities  are traded.  To the extent that the option markets close
before the markets for the  underlying  securities,  significant  price and rate
movements can take place in the  underlying  markets that cannot be reflected in
the option markets.

                                       6
<PAGE>

STOCK INDEX  OPTIONS.  The Fund may purchase  and sell (write)  options on stock
indices  ("index  options").  These options are similar to options on securities
except that, rather than taking or making delivery of securities  underlying the
option at a specified price upon exercise,  an index option gives the holder the
right to  receive  cash upon  exercise  of the  option if the level of the stock
index  upon  which the  option is based is  greater,  in the case of a call,  or
lesser,  in  the  case  of a  put,  than  the  exercise  price  of  the  option.
Transactions  in index options will be effected to hedge  against  adverse price
movements in the stock market generally or in particular market segments.

Options  on stock  indexes  provide  the Fund with a means of seeking to protect
against  the risk of market  wide price  movements.  If the  Investment  Manager
anticipates a market decline,  the Fund could purchase a stock index put option.
If the expected market decline materialized, the resulting decrease in the value
of the Fund's  securities  would be offset to the extent of the  increase in the
value of the put option.  If the Investment  Manager  anticipates a market rise,
the  Fund  may  purchase  a stock  index  call  option  to  enable  the  Fund to
participate  in such rise  until  completion  of  anticipated  stock  purchases.
Purchases and sales of stock index options also enable the Investment Manager to
more efficiently achieve changes in equity positions.

Stock index options  involve risks similar to those  associated  with options on
securities.  However,  because  exercise of stock  index  options are settled in
cash,  call  writers  such as the Fund  cannot  provide  in  advance  for  their
potential  settlement  obligations  by  acquiring  and  holding  the  underlying
securities.  A call write can offset some of the risk of its writing position by
holding  a  diversified  portfolio  of  stocks  similar  to those  on which  the
underlying  index is based.  However,  most  investors  cannot,  as a  practical
matter,  acquire and hold a portfolio  containing exactly the same stocks as the
underlying index and, as a result,  bear a risk that the value of the securities
held  will  vary  from the value of the  index.  For a  discussion  of the risks
associated  with imperfect  correlation of the stock index and the securities in
the Fund's portfolio, see "Investment Objective and Policies--Special Investment
Practices--Hedging."  Even if an index call  writer  could  assemble a portfolio
that exactly  replicated the  composition of the  underlying  index,  the writer
still would not be fully covered from a risk  standpoint  because of the "timing
risk" inherent in writing index options.  When a index option is exercised,  the
amount of cash that the  holder is  entitled  to receive  is  determined  by the
difference  between the exercise  price and the closing  index level on the date
when the option is exercised.  As with other kinds of listed options, the writer
will not learn  that it has been  assigned  an  exercise  notice  until the next
Business Day, at the  earliest.  By the time it learns that it has been assigned
an exercise notice, the index may have declined,  with a corresponding  decrease
in the  value  of  its  stock  portfolio.  This  "timing  risk"  is an  inherent
limitation  on the ability of index call writers to cover their risk exposure by
holding stock positions.  In addition, a holder of an index option who exercises
it before the closing  index value for that day is available  runs the risk that
the level of the  underlying  index may  subsequently  change.  If such a change
causes  the  exercise  price of the option to exceed  the  current  value of the
underlying  securities at the time the option is written,  the exercising holder
will be required to pay the  difference  between the closing index value and the
exercise price of the option (times the  applicable  multiplier) to the assigned
writer.

If dissemination of the current level of an underlying index is interrupted,  or
if trading is interrupted in stocks  accounting for a substantial  percentage of
the value of an index,  the trading of options on that index will  ordinarily be
halted.  If the trading of options on an  underlying  index is halted,  the Fund
would not be able to close out positions and an exchange may impose restrictions
prohibiting the exercise of such options.  If trading in options on the index is
not halted,  the prices of the options may be  distorted.  These  results  could
result in losses to the Fund. It should also be recognized  that the markets for
certain stock index options may be relatively  illiquid,  which could impair the
ability of the Fund to close out positions on such options.



                                       7
<PAGE>

FUTURES  CONTRACTS.  The Fund may enter into  contracts for the purchase or sale
for future  delivery  of baskets of  securities,  financial  indexes,  financial
instruments or foreign currencies.  The Fund will not purchase or sell a futures
contract or purchase an option on a futures contract if, immediately thereafter,
the sum of the amount of initial margin deposits on the Fund's existing  futures
positions,  and premiums  paid on options on futures  contracts  which are still
outstanding,  would exceed 5% of the value of the Fund's  assets.  U.S.  futures
contracts have been designed by exchanges which have been designated  "contracts
markets" by the Commodity Futures Trading Commission and must be executed on the
relevant  contract  market.  Futures  contracts  trade on a number  of  exchange
markets,  and,  through their  clearing  corporations,  the exchanges  guarantee
performance of the contracts as between the clearing members of the exchange.

At the same time a futures contract is purchased or sold, the Fund must allocate
cash or securities as a good faith deposit payment  ("initial margin  deposit").
It is expected that the initial  deposit would be  approximately  5% to 15% of a
contract's face value.  Thereafter,  the Fund must make additional deposits with
the applicable financial intermediary, and will be credited with an amount equal
to any net gains due to favorable price movements.  These additional deposits or
credits are calculated  and required daily and are known as "variation  margin."
The amount of the initial  margin  deposit  required  for a  particular  futures
contract  may be revised  from time to time by the  applicable  exchange  as the
volatility of the contract fluctuates.

Futures  contracts by their terms call for delivery of the underlying  financial
instruments  or,  in the case of index  contracts,  for cash  settlement  at the
delivery  date  of  the  contract.  In  most  cases,  however,  the  contractual
obligation  is  fulfilled  before  the date of  delivery  under the terms of the
contract  through  offset.  The  offsetting  of  a  contractual   obligation  is
accomplished  by  buying  (or  selling,  as the  case  may be) on a  commodities
exchange an identical  futures  contract calling for delivery in the same month.
Such a transaction,  which is effected through a member of an exchange,  cancels
the obligation to make or take delivery  under the terms of the contract.  Since
all transactions in the futures market are made,  offset or fulfilled  through a
clearing house  associated  with the exchange on which the contracts are traded,
the Fund will incur brokerage fees when it purchases or sells futures contracts.

The purpose of the  acquisition  or sale of a futures  contract is to attempt to
protect the Fund from  fluctuations  in the value of the securities  held by the
Fund.  For  example,  if the Fund owns equity  securities  which are expected to
decline in value  temporarily,  the Fund might enter into futures  contracts for
the sale of an index of equity securities. If the Fund's portfolio and the index
tended to  fluctuate  in common,  such a sale would have much the same effect as
selling  an  equivalent  value  of the  securities  owned  by the  Fund.  If the
securities in the portfolio  declined as expected,  the futures contracts to the
Fund would increase at  approximately  the same rate,  thereby  keeping the next
asset value of the Fund from  declining as much as it otherwise  would have. The
Fund could accomplish similar results by selling its securities.  However, since
the  futures  market is more  liquid  than the cash  market,  the use of futures
contracts  as an  investment  technique  allows the Fund to maintain a defensive
position without having to sell its portfolio  securities.  The Fund's portfolio
and the index  will not  necessarily  fluctuate  in  common.  The Fund bears the
additional  risk  that  any  divergence  resulting  from  the  Fund's  portfolio
appreciating  or depreciating  more or less than the index operates  unfavorably
toward the Fund, resulting in a correlation risk similar to that discussed under
"Investment Objective and Policies--Special Investment Practices--Hedging."

Similarly,  when the Fund has a quantity of short  positions in securities  that
are expected to increase in value  temporarily,  or anticipates  the purchase of
such securities,  futures contracts may be purchased to attempt to hedge against


                                       8
<PAGE>

anticipated  losses to the Fund. To the extent that the  fluctuations in futures
contracts  are similar to that of the Fund's short  positions or the  securities
the Fund anticipates acquiring, the Fund could take advantage of the anticipated
rise in value without actually buying the securities.

To the extent the Fund has a short position in a futures contract,  the Fund may
cover by holding the  instruments  or currency  underlying  the  contract or may
maintain  assets in a segregated  account to cover the Fund's  obligations  with
respect to such  futures  contracts.  The assets in such account will consist of
cash, cash equivalents or high quality debt securities in an amount equal to the
difference  between the fluctuating  market value of such futures  contracts and
the  aggregate  value of the initial and variation  margin  payments made by the
Fund with respect to such futures contracts.

The ordinary  spreads  between  prices in the cash and futures  markets,  due to
differences in the nature of those markets,  are subject to distortions.  First,
all  participants  in the  futures  market are  subject to initial  deposit  and
variation margin  requirements.  Rather than meeting additional variation margin
requirements,   investors  may  close  futures  contracts   through   offsetting
transactions  which could distort the normal  relationship  between the cash and
futures  markets.  Second,  the  liquidity  of the  futures  market  depends  on
participants entering into offsetting  transactions rather than making or taking
delivery. To the extent participants decide to make or take delivery,  liquidity
in the future market could be reduced,  thus producing  distortion.  Third, from
the point of view of speculators, the margin deposit requirements in the futures
market are less  onerous  than margin  requirements  in the  securities  market.
Therefore,  increased  participation  by  speculators  in the futures market may
cause  temporary  price  distortions.  Due to the  possibility of distortion,  a
correct  forecast of price  movements  by the  Investment  Manager may still not
result in a successful transaction.

In addition,  futures  contracts entail risks.  Although the Investment  Manager
will only enter into futures contracts if it believes that use of such contracts
will benefit the Fund, if the Investment Manager's investment judgment about the
general  direction of  securities or currency  prices is  incorrect,  the Fund's
overall  performance  would be poorer than if it had not  entered  into any such
contract.  For  example,  if the Fund has hedged  against the  possibility  of a
decline in securities  prices and prices  increase  instead,  the Fund will lose
part or all of the benefit of the increased  value of the securities that it has
hedged  because it will have  offsetting  losses in its  futures  positions.  In
addition, in such situations,  if the Fund has insufficient cash, it may have to
sell securities from its portfolio to meet daily variation margin  requirements.
Such sales of  securities  may be,  but will not  necessarily  be, at  increased
prices which reflect the rising market.  The Fund may have to sell securities at
a time when it may be disadvantageous to do so.

Exchanges may limit the amount by which the price of many futures  contracts may
move on any day. If the price moves equal to the daily limit on successive  days
then it may prove  impossible  to liquidate a futures  position  until the daily
limit moves have ceased.

OPTIONS ON FUTURES  CONTRACTS.  The Fund is  authorized  to  purchase  and write
options on futures contracts for hedging purposes. The purchase of a call option
on a futures  contract  is similar in some  respects  to the  purchase of a call
option on an individual  security.  Upon the exercise of a call option, the Fund
receives a long position in the underlying  futures  contract.  Depending on the
pricing of the option compared to either the price of the futures  contract upon
which it is based or the price of the underlying financial  instruments,  it may
or may not be less risky than  ownership  of the futures  contract.  As with the
purchase  of  futures  contracts,  when the Fund is not  fully  invested  it may
purchase a call option on a futures  contract to hedge against a market  advance
in which it would not otherwise  participate.  The purchase of a put option on a
futures  contract is similar in some respects to the purchase of protective  put
options  on  portfolio  securities.  Upon  exercise  of a put  option,  the Fund


                                       9
<PAGE>

receives a short position in the underlying futures contract.  For example,  the
Fund may  purchase  a put  option on a  futures  contract  to hedge  the  Fund's
portfolio against the risk of declining securities values.

The writing of a call option on a futures  contract  constitutes a partial hedge
against  declining  prices of the  components  of the futures  contract.  If the
futures price at expiration of the call option is below the exercise price,  the
Fund will retain the full amount of the option  premium that  provides a partial
hedge  against  any  decline  that may have  occurred  in the  Fund's  portfolio
holdings.  The  writing  of a put  option on a futures  contract  constitutes  a
partial hedge against  increasing  prices of the  financial  instrument  that is
deliverable  upon termination of the futures  contract.  If the futures price at
expiration  of the put option is higher than the exercise  price,  the Fund will
retain  the full  amount of the option  premium  that  provides a partial  hedge
against  any  increase  in the  price of  securities  that the Fund  intends  to
purchase.  If a put or call option the Fund has written is  exercised,  the Fund
will incur a loss that will be reduced by the amount of the premium it receives.
Depending  on the  degree  of  correlation  between  changes  in  its  portfolio
securities and changes in its futures positions, the Fund's losses from existing
options  may to some  extent be reduced  or  increased  by changes in  portfolio
securities.

The amount of risk the Fund  assumes  when it  purchased  an option on a futures
contract is the premium paid for the option plus related  transaction  costs. In
addition to the  correlation  risks discussed  above,  the purchase of an option
also entails the risk that changes in the underlying  futures  contract will not
be fully reflected in the option purchased.

The Fund's  ability to engage in the options and  futures  strategies  described
above will depend on the availability of liquid markets in such instruments.  It
is  impossible  to  predict  the amount of  trading  interest  that may exist in
various  types of options or futures.  Therefore no assurance  can be given that
the Fund will be able to utilize these instruments  effectively for the purposes
set forth  above.  Furthermore,  the Fund's  ability  to engage in  options  and
futures transactions may be limited by tax considerations.

FOREIGN MARKET  TRANSACTIONS.  In addition,  options on  securities,  options on
indices,  futures  contracts,  and options on futures contracts may be traded on
foreign  exchanges.  Such  transactions  are subject to the risk of governmental
actions affecting trading in or the prices of such options or futures contracts.
Such positions also could be adversely  affected by: (i) other complex  foreign,
political,  and economic  factors;  (ii) lesser  availability than in the United
States of data on which to make  trading  decisions;  (iii) delays in the Fund's
ability  to act  upon  economic  events  occurring  in  foreign  markets  during
non-business  hours in the  United  States;  (iv) the  imposition  of  different
exercise and settlement terms and procedures and margin requirements than in the
United States; and (v) lesser trading volume.

FORWARD CONTRACTS. The Fund may enter into forward contracts to purchase or sell
foreign  currencies as a hedge against  possible  variations in foreign exchange
rates.  A  forward  foreign  currency  contract  is  an  agreement  between  the
contracting  parties to exchange an amount of currency at some future time at an
agreed upon rate. The rate can be higher or lower than the spot rate between the
currencies that are the subject of the contract.  A forward  contract  generally
has no deposit requirement, and such transactions do not involve commissions. By
entering  into a forward  contract  for the  purchase  or sale of the  amount of
foreign  currency  invested in a Foreign  Securities  transaction,  the Fund can
hedge against  possible  variations  in the dollar  versus the subject  currency
either  between the date the Foreign  Security is purchased or sold and the date
on which payment is made or received  during the time the Fund holds the Foreign
Security. The Fund will not speculate in forward currency contracts. If the Fund
enters  into a  "position  hedging  transaction,"  which is the sale of  forward
foreign  currency  with  respect to a  portfolio  security  denominated  in such
foreign  currency,  its custodian  bank will place cash or liquid equity or debt


                                       10
<PAGE>

securities  in a separate  account of the Fund in an amount  equal to the Fund's
total assets  committed to the  consummation  of such forward  contract.  If the
securities placed in the account declines, additional cash or securities will be
placed in the  account so that the  account  will equal the amount of the Fund's
commitment  with  respect  to such  contracts.  The Fund will  purchase  or sell
currency  futures or options on such  futures for the same  reasons as set forth
above for entering into forward foreign  currency  contracts.  The Fund does not
anticipate  attempting to hedge all of its foreign portfolio  positions and will
enter into such transactions  only to the extent, if any, deemed  appropriate by
the Investment  Manager.  The Fund will not enter into a forward  contract for a
term of more than one year.

FUTURE  DEVELOPMENTS.  The Fund may,  following  written  notice  thereof to its
shareholders,  take advantage of opportunities  in the area of options,  futures
contracts,  options on futures contracts,  and other derivative instruments that
are not  currently  contemplated  for use by the Fund or that are not  currently
available but that may be developed,  to the extent such  opportunities are both
consistent with the Fund's investment  objective and legally permissible for the
Fund.  Such  opportunities,  if they arise,  may involve risks that exceed those
involved in the options and futures activities described above.

REGULATORY  RESTRICTIONS.  To the extent required to comply with SEC Release No.
10666, when purchasing a futures contract or writing a put option, the Fund will
maintain,  in a segregated account, cash or liquid securities equal to the value
of such contracts.

The Fund will typically enter into a futures  contract or related option only if
it  constitutes  a bona fide  hedging  position  under  applicable  regulations.
Otherwise the Fund will limit its  investments in futures  contracts and related
options so that, immediately after such investment, the sum of the amount of its
initial  margin  deposits on open  futures  contracts  and its  premiums on open
options  contracts  will not  exceed 5% of the  Fund's  total  assets at current
value.

ACCOUNTING  AND TAX  CONSIDERATIONS.  When the Fund writes an option,  an amount
equal to the premium it receives  is  included  in its  Statement  of Assets and
Liabilities as a liability.  The amount of the liability is subsequently  marked
to market to reflect  the  current  market  value of the  option.  When the Fund
purchases  an  option,  the  premium  it pays is  recorded  as an  asset  and is
subsequently adjusted to the current market value of the option.

In the case of a regulated  futures  contract  purchased or sold by the Fund, an
amount equal to the initial margin  deposit is recorded as an asset.  The amount
of the asset is  subsequently  adjusted to reflect  changes in the amount of the
deposit as well as changes in the value of the contract.

For a discussion of the tax treatment of investments in certain options, futures
and foreign currency contracts, see "Taxation" below.

                                   MANAGEMENT

INVESTMENT MANAGEMENT AGREEMENT

The Investment  Management  Agreement  provides that the Investment Manager will
provide  portfolio   management  services,   place  portfolio   transactions  in
accordance with policies expressed in the Fund's registration statement, pay the
Fund's office rent, and render significant  administrative services on behalf of
the Fund (not  otherwise  provided by third  parties)  necessary  for the Fund's
operation  as a closed-end  fund,  including   preparing  reports to and meeting
materials  for the Fund's  Board of  Trustees  and  reports  and notices to Fund
shareholders;  supervising,  negotiating  contractual  arrangements with, to the
extent  appropriate,  and monitoring the performance of various  third-party and


                                       11
<PAGE>

affiliated  service  providers  to the Fund  (such as the  Fund's  transfer  and
pricing  agents,  custodian,  accountants  and others) and other  persons in any
capacity deemed necessary or desirable to Fund operations;  preparing and making
filings with the SEC and other  regulatory  and  self-regulatory  organizations,
including preliminary and definitive proxy materials,  post-effective amendments
to the Registration Statement and semi-annual reports on Form N-SAR;  overseeing
the  tabulation  of proxies  by the  Fund's  transfer  agent;  assisting  in the
preparation  and  filing of the  Fund's  federal,  state and local tax  returns;
preparing and filing the Fund's federal excise tax returns; providing assistance
with  investor  and  public  relations  matters;  monitoring  the  valuation  of
portfolio  securities and the calculation of NAV; monitoring the registration of
Shares  under  applicable  federal and state  securities  laws;  maintaining  or
causing to be  maintained  for the Fund all books,  records  and reports and any
other information required under the 1940 Act, to the extent such books, records
and reports and other  information are not maintained by the Fund's custodian or
other agents of the Fund;  assisting in establishing  accounting policies of the
Fund;  assisting  in the  resolution  of  accounting  issues that may arise with
respect to the Fund's  operations  and  consulting  with the Fund's  independent
accountants,   legal  counsel  and  other  agents  as  necessary  in  connection
therewith;  establishing  and monitoring the Fund's  operating  expense budgets;
reviewing  the  Fund's  bills;  processing  the  payment of bills that have been
approved by an authorized  person;  assisting the Fund in determining the amount
of  dividends  and other  distributions  available to be paid by the Fund to its
shareholders,  preparing and  arranging for the printing of dividend  notices to
shareholders,  and  providing  the  transfer  and  dividend  paying  agent,  the
custodian,  and the  accounting  agent with such  information as is required for
such parties to effect the payment of  dividends  and other  distributions;  and
otherwise  assisting  the Fund in the  conduct of its  business,  subject to the
direction and control of the Fund's Board of Trustees.

Under the Investment  Management  Agreement,  the Fund is responsible  for other
expenses,  including  organizational expenses (including out-of-pocket expenses,
but not including the Investment Manager's overhead or employee costs); brokers'
commissions or other costs of acquiring or disposing of any portfolio securities
of the Fund;  legal,  auditing and  accounting  expenses;  payment for portfolio
pricing or valuation services to pricing agents, accountants,  bankers and other
specialists,  if any; taxes and governmental  fees; the fees and expenses of the
Fund's transfer agent;  expenses of preparing share  certificates  and any other
expenses,  including clerical  expenses,  of issuance,  offering,  distribution,
sale,  redemption  or  repurchase  of  Shares;  the  expenses  of and  fees  for
registering  or qualifying  securities  for sale; the fees and expenses of those
Trustees  who are not  "interested  persons" of the Fund (as defined in the 1940
Act); the cost of printing and  distributing  reports,  notices and dividends to
current  shareholders;  and the  fees and  expenses  of the  Fund's  custodians,
subcustodians,  dividend disbursing agents and registrars.  The Fund may arrange
to have third parties  assume all or part of the expenses of sale,  underwriting
and  distribution  of  Shares.  The Fund is also  responsible  for  expenses  of
shareholders'  and other meetings and its expenses  incurred in connection  with
litigation  and the  legal  obligation  it may have to  indemnify  officers  and
Trustees of the Fund with respect thereto.  The Fund is also responsible for the
maintenance  of books and records  which are  required to be  maintained  by the
Fund's  custodian  or other  agents of the Fund;  telephone,  telex,  facsimile,
postage and other communications  expenses; any fees, dues and expenses incurred
by  the  Fund  in  connection  with  membership  in  investment   company  trade
organizations;  expenses of printing and mailing  prospectuses and statements of
additional   information  of  the  Fund  and  supplements   thereto  to  current
shareholders; costs of stationery; fees payable to the Investment Manager and to
any other Fund advisers or consultants; expenses relating to investor and public
relations; interest charges, bond premiums and other insurance expense; freight,
insurance  and other  charges  in  connection  with the  shipment  of the Fund's
portfolio securities; and other expenses.



                                       12
<PAGE>

The Investment  Manager is responsible for the payment of the  compensation  and
expenses  of  all  Trustees,  officers  and  executive  employees  of  the  Fund
(including  the Fund's share of payroll  taxes)  affiliated  with the Investment
Manager and making available,  without expense to the Fund, the services of such
Trustees,  officers and  employees as may duly be elected  officers of the Fund,
subject to their individual  consent to serve and to any limitations  imposed by
law. The Fund is responsible for the fees and expenses  (specifically  including
travel  expenses  relating to Fund business) of Trustees not affiliated with the
Investment Manager  ("Non-Interested  Trustees") Under the Investment Management
Agreement,  the Investment  Manager also pays the Fund's share of payroll taxes.
During the Fund's most recent fiscal year, no compensation,  direct or otherwise
(other than through  fees paid to the  Investment  Manager),  was paid or became
payable by the Fund to any of its officers or Trustees who were  affiliated with
the Investment Manager.

On February 3, 1998, the Board of Trustees and the Investment  Manager agreed to
add a breakpoint to the investment  management  fee, such that the Fund pays the
Investment  Manager a fee based on an annual  rate of 1.00% on ending  daily net
assets up to and including $500 million, and 0.90% on ending daily net assets in
excess of $500  million.  For the fiscal year ended  October 31, 1998,  the Fund
paid investment management fees of $ 5,556,255. Additionally, in accordance with
an Administrative  Agreement, the Fund pays the Investment Manager a monthly fee
based on the annual rate of 0.10% on ending daily net assets for  administrative
services.

The Investment Management Agreement further provides that the Investment Manager
shall not be liable for any error of  judgment or mistake of law or for any loss
suffered by any Fund in connection with matters to which such agreement relates,
except a loss resulting from willful misfeasance,  bad faith or gross negligence
on the part of the Investment  Manager in the  performance of its duties or from
reckless disregard by the Investment Manager of its obligations and duties under
such agreement.  The Investment Management Agreement also provides that purchase
and sale  opportunities,  which are  suitable  for more  than one  client of the
Investment Manager,  will be allocated by the Investment Manager in an equitable
manner. Lastly, the Investment Management Agreement contains a provision stating
that it supersedes all prior agreements.

The Investment Management Agreement may be terminated without penalty upon sixty
days' written notice by either party.  The Fund may agree to the  termination of
its  Investment  Management  Agreement  either by the vote of a majority  of the
outstanding  voting  securities  of the  Fund,  or by a vote  of  the  Board  of
Trustees. The Investment Management Agreement may also be terminated at any time
without penalty by the vote of a majority of the outstanding  voting  securities
of the Fund or by a vote of the Board of  Trustees if a court  establishes  that
the Investment  Manager or any of its officers or directors has taken any action
resulting in a breach of the Investment Manager's covenants under the Investment
Management  Agreement.  As stated above,  the  Investment  Management  Agreement
automatically terminates in the event of its assignment.

For the fiscal years ended  October 31, 1998,  1997,  and 1996,  the  Investment
Manager or its predecessor  was paid  investment  management fees of $5,556,255,
$4,880,120, and $4,517,293, respectively.

TRUSTEES AND OFFICERS

The Fund has a Board  composed  of four  Trustees  which  supervises  the Fund's
investment  activities and reviews contractual  arrangements with companies that
provide the Fund with  services.  The Trustees and officers and their  positions
with the Fund and their present and principal  occupations  during the past five
years are listed below.  Each Trustee who is an "interested  person" of the Fund



                                       13
<PAGE>

(as defined in the 1940 Act) is indicated by an asterisk (*).  Each  Independent
Trustee serves on the Audit Committee of the Board.

All of the officers and Trustees of the Fund hold comparable  positions with the
15 mutual funds,  consisting of 53 separate portfolios,  managed or administered
by INVESCO and distributed by INVESCO Distributors,  Inc. (the "INVESCO Funds"),
excluding the Fund.

The Trustees and Executive Officers of the Fund and their principal  occupations
during the last five years are set forth below.

NAME AND AGE          POSITION WITH    PRINCIPAL OCCUPATIONS DURING THE PAST
                      THE FUND         FIVE YEARS
- -----------           ------------     ------------------
CHARLES W.  BRADY,    CHAIRMAN OF THE  Chief Executive  Officer and Director of
Age 64*               BOARD SINCE      AMVESCAP PLC,  London,  England,  and of
                      1991(MR.  BRADY  various subsidiaries  thereof;  Chairman
                      DID NOT SERVE    of the Boards of the INVESCO Funds.
                      AS A TRUSTEE
                      BETWEEN
                      2/28/1997 AND
                      8/3/1998)

FRED A.  DEERING,     TRUSTEE SINCE    Vice  Chairman  of  the  Boards  of  the
Age 71                1992             INVESCO Funds;  formerly Chairman of the
                                       Executive  Committee  and Chairman of the
                                       Board of  Directors  of Security  Life of
                                       Denver   Insurance    Company,    Denver,
                                       Colorado;   Director   of  ING   American
                                       Holdings   Company  and  First  ING  Life
                                       Insurance Company of New York.

JOHN W.  McINTYRE,    TRUSTEE SINCE    Retired.   Formerly,  Vice  Chairman  of
Age 68                1991             the Board of  Directors  of the Citizens
                                       and  Southern  Corporation  and Chairman
                                       of  the  Board   and   Chief   Executive
                                       Officer  of the  Citizens  and  Southern
                                       Georgia Corp.  and Citizens and Southern
                                       National Bank.  Director/Trustee  of the
                                       INVESCO  Funds  and  Kaiser   Foundation
                                       Health  Plan of  Georgia,  Inc.,  Gables
                                       Residential      Trust,       Employee's
                                       Retirement    System   of   GA,    Emory
                                       University,  and  J.M.  Tull  Charitable
                                       Foundation.

DR.  LARRY SOLL,      TRUSTEE SINCE    Retired.   Formerly,   Chairman  of  the
Age 56                1991             Board  (1987 to 1994),  Chief  Executive
                                       Officer  (1982  to  1989;  1993 to 1994)
                                       and   President   (1982   to   1989)  of
                                       Synergen    Inc.    (a     biotechnology
                                       company),       Boulder,       Colorado.
                                       Director/Trustee  of the INVESCO  Funds.
                                       Director   of    Synergen    since   its
                                       incorporation   in  1982.   Director  of
                                       Isis Pharmaceuticals, Inc.


                                       14
<PAGE>


MARK H.               PRESIDENT, AND   President,  Chief Executive Officer, and
WILLIAMSON,           CHIEF OPERATING  Director,   INVESCO  Distributors  Inc.;
Age 47                OFFICER SINCE    President,  Chief Executive  Officer and
                      1998             Chairman,  INVESCO;  Formerly,  Chairman
                                       of  the  Board   and   Chief   Executive
                                       Officer,   NationsBanc  Advisors,   Inc.
                                       (1995-1997);   Chairman  of  the  Board,
                                       NationsBanc      Investments,       Inc.
                                       (1997-1998).

RONALD L.  GROOMS,    TREASURER SINCE  Senior Vice  President  and Treasurer of
Age 52                1991             INVESCO   Funds   Group,   Inc.   (since
                                       1988).   Senior   Vice   President   and
                                       Treasurer of INVESCO Distributors,  Inc.
                                       (since 1997).

GLEN A.  PAYNE,       SECRETARY SINCE  Senior Vice  President,  General Counsel
Age 52                1991             and  Secretary  of INVESCO  Funds Group,
                                       Inc.    (since   1995),    and   INVESCO
                                       Distributors,  Inc.  (since 1997);  Vice
                                       President,    Secretary    and   General
                                       Counsel of  INVESCO  Funds  Group,  Inc.
                                       (May  1989  to  April  1995);  formerly,
                                       employee  of a U.S.  regulatory  agency,
                                       Washington,   D.C.  (June  1973  through
                                       May 1989).

JOHN R.  SCHROER,     VICE PRESIDENT   Senior Vice  President of INVESCO  Funds
Age 32                SINCE 1996       Group,  Inc.  and  portfolio  manager of
                                       the   Fund   (since   1996).   Portfolio
                                       manager of the INVESCO  Strategic Health
                                       Sciences Fund.


Unless otherwise indicated,  the address of each Trustee and officer of the Fund
is Post Office Box 173706, Denver, Colorado 80217-3706.
- --------
*Because of Mr. Brady's affiliation with INVESCO,  or with companies  affiliated
with INVESCO, he is deemed to be an "interested person" of INVESCO Global Health
Sciences Fund, as that term is defined in the 1940 Act.

The Board has an Audit Committee that is composed of Messrs.  Deering,  Soll and
McIntyre.  The  Committee  makes  recommendations  regarding  the  selection  of
independent  auditors  for the  Fund,  confers  with  the  independent  auditors
regarding  the Fund's  financial  statements,  the results of audits and related
matters, and performs other tasks as the Board assigns.



                                       15
<PAGE>

COMPENSATION OF TRUSTEES

The  Trustees  and officers who are  "interested  persons" as  designated  above
receive no  compensation  from the Fund.  The table below shows  amounts paid or
accrued to those Trustees who are not designated "interested persons" during the
Fund's fiscal year ended October 31, 1998, except that the information regarding
the total  compensation from the Fund and Fund Complex in the last column is for
the calendar year 1998.

The  following  table  shows  the  compensation  paid by the  Fund to its  three
Independent  Trustees  for their  services as Trustees of the Fund in the fiscal
year  ended  October  31,  1998.  The  following  table  also  shows  the  total
compensation paid by the Fund and the INVESCO Funds (collectively,  the 54 funds
of the  "INVESCO  Complex",  including  the  Fund) to these  Trustees  for their
services as Directors or Trustees during the year ended December 31, 1998.

COMPENSATION TABLE

                               AMOUNTS PAID DURING THE MOST RECENT
                               FISCAL YEAR BY THE FUND TO TRUSTEES

                                                                     TOTAL 
                    AGGREGATE      BENEFITS       ESTIMATED   COMPENSATION FROM
                   COMPENSATION   ACCRUED AS       ANNUAL        THE FUND AND
                    FROM THE     PART OF FUND  BENEFITS UPON  INVESCO FUNDS PAID
NAME OF TRUSTEE        FUND       EXPENSES(2)   RETIREMENT(3) PAID TO TRUSTEES
- ---------------        ----       -----------   ------------------------------

FRED A.  DEERING     $19,000         $0.00            $           $103,700
JOHN W.  MCINTYRE(1) $20,000         $0.00            $            $98,500
DR.  LARRY SOLL      $19,000         $0.00            $            $96,000
                   ----------    ------------    ----------    --------------
TOTAL                $58,000         $0.00            $           $298,200
- -----

AS A PERCENTAGE OF
NET ASSETS            0.0099%(4)      0.00%                         0.0014%(5)

- ------

(1) The chairman of the audit  committee  receives  compensation  for serving in
such capacity in addition to the compensation paid to all Independent  Trustees.

(2) Represents  benefits  accrued with respect to the Defined  Benefit  Deferred
Compensation Plan discussed below, and not compensation deferred at the election
of the  Trustees.  This Plan was adopted by the Board of Trustees on October 12,
1998,  and as of October 31, 1998,  the Fund's fiscal year end, no benefits have
begun accruing to eligible Trustees.

(3) These figures  represent the Fund's  estimated  annual benefits payable upon
the trustee's  retirement.  These estimated benefits assume retirement at age 72
and  that  the  basic  retainer   payable  to  the  Trustees  will  be  adjusted
periodically  for  inflation.  This  results  in lower  estimated  benefits  for
Trustees who are closer to retirement and higher estimated benefits for Trustees
who are farther from  retirement.  Each of these  Trustees has served as Trustee
for the minimum  five-year  period required to be eligible to participate in the
Defined  Benefit  Deferred  Compensation  Plan.

(4) Total as a percentage of the Fund's net assets as of October 31, 1998.

(5) Total as a percentage of the INVESCO Complex's net assets as of December 31,
1998.

The Fund's Independent Trustees (as defined under the 1940 Act) and of the other
funds in the INVESCO Complex  establish their own compensation from the Fund and
other funds in the INVESCO Complex and are not paid by INVESCO or any affiliated
company.  Mr. Brady, as an "interested person" of the Fund and of other funds in
the INVESCO Complex, receives compensation as an officer of companies affiliated
with INVESCO,  but does not receive any trustee fees or other  compensation from
the Fund or from other funds in the INVESCO Complex for his service as a Trustee
or Director.

The  Board of  Trustees  of the Fund has  adopted  a  Defined  Benefit  Deferred
Compensation Plan (the "Benefit Plan") for the Independent Trustees of the Fund.
Under the Benefit Plan, each Trustee who is not an interested person of the Fund
(as  defined in  Section  2(a)(19)  of the 1940 Act),  and who has served for at


                                       16
<PAGE>

least five years (a "Qualified  Trustee") is entitled to receive four  quarterly
payments during the first twelve months after his or her  retirement,  with each
payment to be equal to 25 percent of the sum of the annual  basic  retainer  and
annualized  quarterly  board meeting fees payable by the Fund to the Independent
Trustee on his or her retirement (the "First Year Retirement Payment"). Trustees
normally  retire at age 72, 73, 74 or 75 if the  retirement  date is extended by
the  Board.  In no event may a  Trustee  retire  later  than the last day of the
calendar quarter in which the Trustee's seventy-fifth birthday occurs.

Beginning with the first anniversary of the Qualified Trustee's retirement,  and
beginning as of the  retirement of an  Independent  Trustee whose  retirement is
after the date of the last day of the calendar  quarter in which such  Trustee's
seventy-fifth  birthday occurred,  the Independent Trustee will receive, for the
remainder of his or her life, a benefit (the "Benefit"), payable quarterly, with
each  quarterly  payment  to be equal to 12.50% of the sum of the  annual  basic
retainer and annualized quarterly Board meeting fees payable by the Trust to the
Independent Trustee on his or her retirement.

If an Independent Trustee's service as a Trustee is terminated because of his or
her death  after the last day of the  calendar  quarter in which such  Trustee's
seventy-second birthday occurred and before the last day of the calendar quarter
in  which  such  Trustee's   seventy-fifth   birthday  occurs,   the  designated
beneficiary of the  Independent  Trustee will receive the First Year  Retirement
Payments and will, beginning with the quarter following the quarter in which the
last First Year Retirement  Payment is made, receive the Benefit for a period of
ten years, with quarterly payments to be made to the designated beneficiary.

If an Independent Trustee's service as a Trustee is terminated because of his or
her death  before the last day of the calendar  quarter in which such  Trustee's
seventy-second  birthday occurs or after the last day of the calendar quarter in
which such Trustee's seventy-fifth birthday occurred, the designated beneficiary
of the  Independent  Trustee will receive the Benefit for a period of ten years,
with quarterly  payments to be made to the designated  beneficiary  beginning in
the first quarter following the Trustee's death.

If an Independent Trustee's service as a Trustee is terminated because of his or
her  disability  after  the  last day of the  calendar  quarter  in  which  such
Trustee's  seventy-second  birthday  occurred  and  before  the  last day of the
calendar  quarter in which such Trustee's  seventy-fifth  birthday  occurs,  the
Independent  Trustee will receive the First Year  Retirement  Payments and will,
beginning  with the quarter  following  the quarter in which the last First Year
Retirement  Payment is made, receive the Benefit for the remainder of his or her
life, with quarterly payments to be made to the disabled Independent Trustee. If
the disabled  Independent  Trustee  should die before the First Year  Retirement
Payments are completed  and before forty  quarterly  Benefit  payments are made,
such payments will continue to be made to the Independent  Trustee's  designated
beneficiary until the aggregate of the First Year Retirement  Payments and forty
quarterly  Benefit payments have been made to the disabled  Independent  Trustee
and the Trustee's designated beneficiary.

If an Independent Trustee's service as a Trustee is terminated because of his or
her  disability  before  the  last day of the  calendar  quarter  in which  such
Trustee's  seventy-second  birthday occurs or after the last day of the calendar
quarter in which such Trustee's seventy-fifth birthday occurred, the Independent
Trustee  will  receive the Benefit for the  remainder  of his or her life,  with
quarterly payments to be made to the disabled  Independent  Trustee beginning in
the first quarter  following the Trustee's  termination for  disability.  If the
disabled  Independent  Trustee  should die before forty  quarterly  payments are
made, payments will continue to be made to the Independent  Trustee's designated


                                       17
<PAGE>

beneficiary until the aggregate of forty quarterly payments has been made to the
disabled Independent Trustee and the Trustee's designated beneficiary.

Any question  involving  entitlement to payments under or the  administration of
the Benefit Plan will be referred to a four-person  committee (the  "Committee")
composed of three  Independent  Trustees  designated  by all of the  Independent
Trustees and one Trustee who is not an  Independent  Trustee,  designated by the
non-Independent  Trustee.  Except as otherwise provided, the Committee will make
all  interpretations  and determinations  necessary or desirable for the Benefit
Plan's administration, and such interpretations and determinations will be final
and conclusive. Committee members will be elected annually.

The  Committee  will  represent and act on behalf of the Trust in respect of the
Benefit  Plan and,  subject to the other  provisions  of the Benefit  Plan,  the
Committee may adopt, amend or repeal bylaws or other regulations relating to the
administration of the Benefit Plan, the conduct of the Committee's  affairs, its
rights or powers,  or the rights or powers of its members.  The  Committee  will
report to the  Independent  Trustees  and to the Board  from time to time on its
activities in respect of the Benefit Plan.  The Committee or persons  designated
by it  will  cause  such  records  to be  kept  as  may  be  necessary  for  the
administration  of the Benefit Plan. The cost of the Benefit Plan is paid by the
Trust.

On October 12, 1998   the Board of Trustees  adopted a Deferred  Fee  Agreement,
pursuant to which the Independent Trustees may defer receipt of a portion of the
compensation  which they would otherwise have been paid as Trustees of the Fund.
The deferred amount is invested in Shares. Each Independent Trustees, therefore,
may be an indirect owner of Shares,  in addition to any Shares that may be owned
directly.

OWNERSHIP OF FUND SHARES

As of [       ] 1999,  the  Trustees  and  officers of the Fund as a group owned
[XXXX] Shares, representing __% of the outstanding Shares.

As of [       ] 1999,  the following  persons owned, beneficially  or of record,
more than 5% of the outstanding Shares:

NAME AND ADDRESS             NUMBER OF SHARES     PERCENTAGE OF OUTSTANDING
                                                  SHARES
- ------------------           ---------            ---------
                             [XXXXXXX]            [X.XX%]

                             [XXXXXXX]            [X.XX%]

                             [XXXXXXX]            [X.XX%]

                             [XXXXXXX]            [X.XX%]

                             [XXXXXXX]            [X.XX%]

                             

                                       18
<PAGE>

                             PORTFOLIO TRANSACTIONS

The  Investment  Manager  places  orders for the purchase and sale of securities
with  brokers  and  dealers   based  upon  its   evaluation   of  the  financial
responsibility  of the brokers and  dealers,  and  considering  the brokers' and
dealers'  ability  to effect  transactions  at the best  available  prices.  The
Investment Manager evaluates the overall reasonableness of brokerage commissions
paid by reviewing the quality of executions  obtained on portfolio  transactions
of the Fund,  viewed  in terms of the size of  transactions,  prevailing  market
conditions in the security  purchased or sold,  and general  economic and market
conditions.  In seeking to ensure that any commissions or discounts  charged the
Fund are consistent with prevailing and reasonable  commissions,  the Investment
Manager also endeavors to monitor  brokerage  industry  practices with regard to
the commissions  charged by  broker-dealers  on transactions  effected for other
comparable   institutional   investors.   While  the  Investment  Manager  seeks
reasonably  competitive  rates,  the Fund does not  necessarily  pay the  lowest
commission, spread or discount available.

Consistent  with the  standard  of  seeking  to  obtain  the best  execution  on
portfolio  transactions,  the Investment Manager may select brokers that provide
research  services to effect such  transactions.  Research  services  consist of
statistical and analytical reports relating to issuers,  industries,  securities
and  economic  factors and trends,  which may be of  assistance  or value to the
Investment Manager in making informed  investment  decisions.  Research services
prepared and  furnished  by brokers  through  which the Funds effect  securities
transactions  may be used by the  Investment  Manager  in  servicing  all of its
accounts  and not all such  services  may be used by the  Investment  Manager in
connection with the Fund.

In  recognition  of the  value of the  above-described  brokerage  and  research
services provided by certain brokers,  the Investment  Manager,  consistent with
the standard of seeking to obtain the best execution on portfolio  transactions,
may place orders with such brokers for the  execution  of  transactions  for the
Fund on which the  commissions  are in excess of those which other brokers might
have charged for effecting the same transactions.

Portfolio  transactions may be effected through  qualified  broker-dealers  that
recommend  the Fund to their  clients or who act as agent in the purchase of the
Shares for their  clients.  When a number of brokers  and  dealers  can  provide
comparable best price and execution on a particular transaction,  the Investment
Manager may consider the sale of Shares by a broker or dealer in selecting among
qualified broker-dealers.

The  Fund  paid  $1,511,837,  $1,746,140,  and $ [    ] in brokerage commissions
during the  fiscal  years  ended October  31, 1998,  1997, and  1996. Of   these
amounts, $64,075, $87,007 and  $[    ]  were paid to the Dealer Manager.

PORTFOLIO TURNOVER

Generally, the Fund will not purchase securities for short-term trading profits.
However, the Fund may dispose of securities without regard to the time they have
been held when such actions, for defensive or other reasons, appear advisable to
the Investment  Manager.  (The portfolio turnover rate is calculated by dividing
the lesser of  purchases  or sales of portfolio  securities  for the  particular
fiscal  year by the  monthly  average of the value of the  portfolio  securities
owned by the Fund during the particular fiscal year. For purposes of determining
this rate, all securities  whose  maturities at the time of acquisition  are one
year or less are  excluded.)  The  annual  rate of the  Fund's  total  portfolio
turnover for the years ended  December 31, 1998,  1997,  and 1996 was 87%, 145%,
and 91%, respectively.

                     

                                       19
<PAGE>

                     REPURCHASE OF SHARES AND TENDER OFFERS

Shares of closed-end funds frequently trade at a discount from NAV per share but
in some cases trade at a premium.  In  recognition of the  possibility  that the
Shares  might  similarly  trade at a discount,  the Fund's Board of Trustees has
determined that it would be in the interest of shareholders for the Fund to take
action to attempt to reduce or  eliminate a market value  discount  from NAV. To
that end,  the Board  contemplates  that the Fund could from  time-to-time  take
action either to  repurchase  its Shares in the open market or to tender for its
own Shares at NAV. The Board, in consultation with the Investment Manager,  will
review on a quarterly  basis the possibility of open market  repurchases  and/or
tender offers for Shares.  There are no assurances that the Board will, in fact,
decide to undertake either of these actions or, if undertaken, that such actions
will result in the Shares  trading at a market  price per Share that is equal to
or approximates their NAV per Share. In addition, the Board will not necessarily
announce when it has given consideration to these matters.

Subject to the Fund's  investment  policies  and  restrictions  with  respect to
borrowings,  the Fund may incur debt to finance repurchases and/or tenders.  See
"Investment   Objective  and  Policies"  in  the  Prospectus   and   "Investment
Restrictions" herein. Interest on any such borrowings will reduce the Fund's net
investment income.

The Fund  anticipates that the market price of its Shares will from time to time
vary from their NAV per Share.  The market  price of the per Share  will,  among
other  things,  be  determined  by the  relative  demand for and supply of those
Shares in the market, the Fund's investment performance, its dividends and yield
and  investor  perception  of its overall  attractiveness  as an  investment  as
compared with other  investment  alternatives.  Nevertheless,  the fact that the
Shares may be repurchased or be the subject of tender offers at NAV from time to
time may reduce the spread  between  market  price and NAV that might  otherwise
exist. In the opinion of the Investment Manager, sellers may be more inclined to
accept a  significant  discount if they have a reasonable  expectation  of being
able to recover NAV in conjunction with a possible repurchase or tender offer.

Although the Board of Trustees believes that share repurchases and tender offers
generally would have a favorable effect on the market price per Share, it should
be recognized that the acquisition of Shares by the Fund will decrease its total
assets and, therefore,  have the effect of increasing its expense ratio. Because
of the nature of the Fund's investment objective and policies and its portfolio,
the Investment  Manager does not anticipate  that  repurchases and tender offers
should have a materially adverse effect on the Fund's investment performance and
does not anticipate any material difficulty in disposing of portfolio securities
in order to consummate share repurchases and tender offers.

It is the Board of Trustees' announced policy,  which the Board may change, that
the Fund cannot accept tenders or effect  repurchases if (1) such  transactions,
if consummated, would (a) result in delisting the Shares from the NYSE (the NYSE
having advised the Fund that it would consider delisting if the aggregate market
value of the outstanding Shares is less than $5,000,000,  the number of publicly
held Shares falls below  600,000 or the number of round-lot  holders falls below
1,200) or (b)  terminate  the Fund's  status as a regulated  investment  company
under the Code  (which  would  cause the Fund's  income to be taxed at the trust
level in addition to being taxed when the  shareholders  receive  dividends from
the Fund),  (2) the amount of securities  tendered would require  liquidation of
such a substantial portion of the Fund's securities that it would not be able to
liquidate  portfolio  securities  in an orderly  manner in light of the existing
market  conditions and such liquidation  would have an adverse effect on the NAV
of the Fund to the detriment of  nontendering  shareholders  or (3) there is, in
the Board of Trustees'  judgment,  any  material (a) legal action or  proceeding
instituted or threatened  challenging such transactions or otherwise  materially


                                       20
<PAGE>

adversely  affecting  the Fund,  (b)  suspension  of or limitation on prices for
trading  securities  generally  on the  NYSE or any  foreign  exchange  on which
portfolio  securities  of the Fund are  traded,  (c)  declaration  of a  banking
moratorium by federal, state or foreign authorities or any suspension of payment
by banks in the United States,  New York State or foreign countries in which the
Fund invests,  (d) limitation affecting the Fund or the issuers of its portfolio
securities imposed by federal,  state or foreign authorities on the extension of
credit by lending  institutions  or on the  exchange  of foreign  currency,  (e)
commencement  of war,  armed  hostilities  or other  international  or  national
calamity  directly or indirectly  involving the United States or other countries
in which the Fund invests or (f) other event or condition that would have a
material  adverse  effect  on  the  Fund  or its  shareholders  if  Shares  were
repurchased.  The Board of  Trustees  may modify  these  conditions  in light of
experience.

Any tender  offer made by the Fund will be at a price equal to the NAV per Share
on a date  subsequent to the Fund's receipt of all tenders.  During the pendency
of any tender offer by the Fund, it will  calculate  daily the NAV of the Shares
and will  establish  procedures  that  will be  specified  in the  tender  offer
documents, to enable shareholders to ascertain readily such NAV. Each offer will
be made and shareholders will be notified in accordance with the requirements of
the Securities  Exchange Act of 1934 and the 1940 Act,  either by publication or
mailing or both. Each offering document will contain the information  prescribed
by those  laws and the  rules and  regulations  promulgated  thereunder.  When a
tender offer is  authorized  to be made by the Fund's  Trustees,  a  shareholder
wishing to accept the offer  will be  required  to tender all (but not less than
all) of the Shares owned by the shareholder (or  constructively  owned by him or
her for federal  income tax purposes  under  section 318 of the Code).  The Fund
will not  specify a record  date for the  tender  offer  that will not  permit a
shareholder of record on the effective date of the tender offer to tender his or
her Shares.  The Fund will purchase all Shares  tendered in accordance  with the
terms of the offer unless it  determines  to accept none of them (based upon one
of the conditions set forth above). Each person tendering Shares will pay to the
Fund a reasonable service charge currently  anticipated to be [$25.00],  subject
to change,  to help defray  certain  costs,  including the  processing of tender
forms, effecting payment,  postage and handling. It is the position of the staff
of the SEC that such service charge may not be deducted from the proceeds of the
purchase.  The Fund's  transfer agent will receive the fee as an offset to these
costs.  The Fund  expects the costs to the Fund of effecting a tender offer will
exceed the aggregate of all service charges received from those who tender their
Shares. Costs associated with the tender will be charged against capital.

Tendered  Shares that have been  accepted and purchased by the Fund will be held
in treasury and may be retired by the Trustees. Treasury Shares will be recorded
and reported as an offset to  shareholders'  equity and accordingly  will reduce
the Fund's  total  assets.  If treasury  Shares are retired,  Shares  issued and
outstanding and capital in excess of par value will be reduced.

If the Fund must liquidate  portfolio  securities in order to purchase  tendered
Shares, it may realize gains and losses. The portfolio turnover rate of the Fund
may or may not be affected  by the Fund's  repurchases  of Shares  pursuant to a
tender offer.

                                    TAXATION

Set  forth  below  is  a  discussion   of  certain  U.S.   federal   income  tax
considerations affecting the Fund and the purchase, ownership and disposition of
Shares.  This  discussion  does not  purport to be  complete or to deal with all
aspects of federal income taxation that may be relevant to shareholders in light
of  their  particular  circumstances.   This  discussion  is  based  on  current
provisions  of  the  Code,  the  regulations  promulgated  thereunder,  judicial
decisions and administrative pronouncements,  all of which are subject to change
(some of which may be retroactive).  Prospective  investors should consult their


                                       21
<PAGE>

own tax advisors  with regard to the federal tax  consequences  of the purchase,
ownership and  disposition of Shares,  as well as the tax  consequences  arising
under the laws of any state, foreign country or other taxing jurisdiction.

TAX TREATMENT OF THE FUND

GENERAL.  The Fund intends to continue to qualify  each year for  treatment as a
regulated  investment company under the Code ("RIC"). For each taxable year that
it so qualifies, the Fund (but not its shareholders) will be relieved of federal
income tax on the part of its  investment  company  taxable  income  (consisting
generally of net investment  income,  net short-term  capital gain and net gains
from certain foreign currency  transactions) and net capital gain (the excess of
net long-term capital gain over net short-term capital loss) that it distributes
to its shareholders.

To qualify for treatment as a RIC, the Fund must distribute to its  shareholders
for each  taxable year at least 90% of its  investment  company  taxable  income
("Distribution  Requirement")  and must meet  several  additional  requirements.
These requirements include the following:  (1) the Fund must derive at least 90%
of its gross income each taxable year from  dividends,  interest,  payments with
respect  to  securities  loans and gains from the sale or other  disposition  of
securities or foreign currencies, or other income (including gains from options,
futures or forward  contracts) derived with respect to its business of investing
in securities or those currencies  ("Income  Requirement");  (2) at the close of
each quarter of the Fund's  taxable year, at least 50% of the value of its total
assets must be represented by cash and cash items, U.S.  government  securities,
securities of other RICs and other  securities  that are limited,  in respect of
any one issuer,  to an amount that does not exceed 5% of the value of the Fund's
total  assets  and  that  does  not  represent  more  than  10% of the  issuer's
outstanding  voting  securities;  and (3) at the  close of each  quarter  of the
Fund's  taxable year,  not more than 25% of the value of its total assets may be
invested in securities of any one issuer (other than U.S. government  securities
or the securities of other RICs). If the Fund failed to qualify for treatment as
a RIC for any taxable year, it would be taxed as an ordinary  corporation on the
full  amount of its  taxable  income  for that  year  (even if that  income  was
distributed to its  shareholders)  and all distributions out of its earnings and
profits,  including  distributions  of net capital gain, would be taxable to its
shareholders as dividends (I.E.,  ordinary income). In addition,  the Fund could
be required to recognize  unrealized  gains, pay substantial  taxes and interest
and make substantial distributions before requalifying for RIC treatment.

The Fund will be subject to a non-deductible 4% excise tax ("Excise Tax") to the
extent it fails to distribute by the end of any calendar year  substantially all
of its  ordinary  income  for that  year and  capital  gain net  income  for the
one-year period ending on October 31st of that year, plus certain other amounts.
For these  purposes,  any such income retained by the Fund, and on which it pays
federal income tax, will be treated as having been distributed.

FOREIGN  SECURITIES.  The Fund may  invest  in the  stock  of  "passive  foreign
investment companies" ("PFICs"). A PFIC is any foreign corporation (with certain
exceptions) that, in general,  meets either of the following tests: (1) at least
75% of its gross  income is passive  income or (2) an average of at least 50% of
its assets  produce,  or are held for the production of, passive  income.  Under
certain  circumstances,  the Fund will be  subject  to  federal  income tax on a
portion of any "excess  distribution"  received on the stock of a PFIC or of any
gain on disposition of the stock  (collectively  "PFIC  income"),  plus interest
thereon,  even if the Fund  distributes  the PFIC  income as a  dividend  to its
shareholders.  The  balance of the PFIC  income  will be  included in the Fund's
investment company taxable income and, accordingly, will not be taxable to it to
the extent it distributes that income to its shareholders.




                                       22
<PAGE>

In lieu of the foregoing tax and interest obligation,  the Fund may, and intends
to,  elect to "mark to market"  its stock in any PFIC.  "Marking-to-market,"  in
this context,  means  including in ordinary income each taxable year the excess,
if any, of the fair  market  value of the stock over the Fund's  adjusted  basis
therein  as of the end of that year.  Pursuant  to the  election,  the Fund also
would be allowed to deduct (as an ordinary,  not capital,  loss) the excess,  if
any, of its adjusted  basis in PFIC stock over the fair market value  thereof as
of the taxable year-end,  but only to the extent of any net mark-to-market gains
with  respect to that  stock  included  in income by the Fund for prior  taxable
years under the election (and under regulations proposed in 1992 that provided a
similar  election  with  respect  to the stock of  certain  PFICs).  The  Fund's
adjusted basis in each PFIC's stock subject to the election would be adjusted to
reflect the amounts of income included and deductions taken thereunder.

Gains from the  disposition of foreign  currencies will be treated as qualifying
income under the Income Requirement. Gains or losses (1) from the disposition of
foreign  currencies,  including forward  contracts,  (2) on the disposition of a
foreign-currency-denominated debt security that are attributable to fluctuations
in the  value of the  foreign  currency  between  the dates of  acquisition  and
disposition  of the  security  and (3) that are  attributable  to exchange  rate
fluctuations  between the time the Fund  accrues  interest,  dividends  or other
receivables, or accrues expenses or other liabilities,  denominated in a foreign
currency and the time the Fund  actually  collects the  receivables  or pays the
liabilities,  generally  are treated as ordinary  income or loss.  These  gains,
referred  to under  the Code as  "section  988"  gains or  losses,  increase  or
decrease the amount of the Fund's investment company taxable income available to
be distributed to its shareholders as ordinary income, rather than increasing or
decreasing  the amount of its net capital gain.  In the case of overlap  between
sections  988 and 1256  (see  below  under  "Derivatives"),  special  provisions
determine the character and timing of any income, gain or loss.

Income received by the Fund from investments in Foreign Securities, and gains it
derives from the disposition thereof,  may be subject to income,  withholding or
other taxes imposed by foreign countries and U.S.  possessions that would reduce
the total return on its investments.  Tax conventions  between certain countries
and the United  States may reduce or eliminate  those taxes,  however,  and many
foreign countries do not impose taxes on capital gains in respect of investments
by foreign  investors.  Foreign taxes  withheld from or paid by the Fund will be
treated  as a Fund  expense  unless  it meets  the  requirements,  and  makes an
election,  to  enable  it,  in  effect,  to  pass  these  taxes  through  to its
shareholders  for  use by  them as a  foreign  tax  credit  or  deduction.  Each
shareholder will be notified annually whether the foreign taxes paid by the Fund
will "pass through" for that year and, if so, the  shareholder's  portion of (1)
the  foreign  taxes  paid by the Fund and (2)  dividends  paid by the Fund  that
represent income derived from foreign sources. Individuals who have no more than
$300 ($600 for married  persons  filing  jointly) of  creditable  foreign  taxes
included  on Forms 1099 and all of whose  foreign  source  income is  "qualified
passive income" may elect each year to be exempt from the extremely  complicated
foreign  tax  credit  limitation,  in which  event they would be able to claim a
foreign tax credit  without having to file the detailed Form 1116 that otherwise
is required.

DERIVATIVES.  The use of  certain  derivatives,  such as selling  (writing)  and
purchasing  options and futures and entering  into forward  contracts,  involves
complex rules that will  determine  for federal  income tax purposes the amount,
character and timing of recognition of the gains and losses the Fund realizes in
connection therewith.  These rules also may require the Fund to "mark to market"
(that is, treat as sold for their fair market  value) at the end of each taxable
year certain  positions in its portfolio,  which may cause the Fund to recognize
income or gain without receiving cash with which to make distributions necessary
to satisfy the Distribution  Requirement and avoid imposition of the Excise Tax.
Gains from  options,  futures  and  forward  contracts  derived by the Fund with
respect to its business of investing in securities or foreign currencies will be
treated as qualifying income under the Income Requirement.



                                       23
<PAGE>

Certain futures and foreign currency  contracts in which the Fund may invest may
be subject to section 1256 of the Code ("section 1256  contracts").  Any section
1256  contracts  the Fund holds at the end of each taxable year (other than such
contracts that are part of a "mixed straddle" with respect to which the Fund has
elected   not  to  have  the   following   rules   apply)   generally   must  be
marked-to-market for federal income tax purposes.  Sixty percent of any net gain
or loss  recognized on these deemed  sales,  and 60% of any net realized gain or
loss from any  actual  sales of  section  1256  contracts,  will be  treated  as
long-term  capital gain or loss,  and the balance will be treated as  short-term
capital  gain or loss.  These rules may operate to increase  the amount that the
Fund must distribute to satisfy the Distribution Requirement (I.E., with respect
to the portion treated as short-term capital gain), which will be taxable to the
shareholders  as  ordinary  income,  and to  increase  the net  capital  gain it
recognizes,  without in either case  increasing  the cash available to the Fund.
The Fund may elect to exclude certain transactions from the operation of section
1256,  although  doing  so may  have  the  effect  of  increasing  the  relative
proportion of net short-term  capital gain (taxable as ordinary income) and thus
increasing the amount of dividends that must be distributed.

Gain or loss  realized by the Fund on the  expiration or sale of certain OTC put
and call options it holds will be either long-term or short-term capital gain or
loss,  depending  on its holding  period for the option.  However,  gain or loss
realized on the  expiration  or closing out of such  options that are written by
the Fund will be treated as short-term capital gain or loss. In general,  if the
Fund  exercises an option,  or an option that the Fund has written is exercised,
gain or loss on the option will not be  separately  recognized,  but the premium
received  or  paid  will  be  included  in the  calculation  of  gain or loss on
disposition of the property underlying the option.

Offsetting positions in any actively traded security, option, futures or forward
contract  entered  into or held by the  Fund may  constitute  a  "straddle"  for
federal  income tax  purposes.  Straddles  are subject to certain rules that may
affect the  amount,  character  and timing of the Fund's  gains and losses  with
respect to positions of the straddle by requiring,  among other things, that (1)
loss  realized on  disposition  of one position of a straddle be deferred to the
extent  of any  unrealized  gain in an  offsetting  position  until  the  latter
position  is  disposed  of, (2) the Fund's  holding  period in certain  straddle
positions not begin until the straddle is terminated (possibly resulting in gain
being treated as short-term  rather than long-term  capital gain) and (3) losses
recognized  with respect to certain  straddle  positions,  that otherwise  would
constitute  short-term  capital losses,  be treated as long-term capital losses.
Applicable  regulations  also provide certain "wash sale" rules,  which apply to
transactions where a position is sold at a loss and a new offsetting position is
acquired  within a  prescribed  period,  and "short  sale" rules  applicable  to
straddles. Different elections are available to the Fund, which may mitigate the
effects of the straddle rules, particularly with respect to any "mixed straddle"
(I.E., a straddle of which at least one, but not all, positions are section 1256
contracts).

If the Fund has an "appreciated  financial  position" -- generally,  an interest
(including an interest  through an option,  futures or forward contract or short
sale) with respect to any stock, debt instrument (other than "straight debt") or
partnership  interest the fair market value of which exceeds its adjusted  basis
- -- and enters into a "constructive  sale" of the same or  substantially  similar
property,  the Fund will be treated as having made an actual sale thereof,  with
the result  that gain will be  recognized  at that  time.  A  constructive  sale
generally consists of a short sale, an offsetting notional principal contract or
a futures or forward  contract entered into by the Fund or a related person with
respect to the same or  substantially  similar  property.  In  addition,  if the
appreciated  financial  position  is  itself  a short  sale or such a  contract,
acquisition of the underlying property or substantially similar property will be
deemed a  constructive  sale.  The  foregoing  will not apply,  however,  to any
transaction  during  any  taxable  year that  otherwise  would be  treated  as a
constructive  sale if the  transaction is closed within 30 days after the end of

                                       24
<PAGE>

that year and the Fund holds the appreciated  financial position unhedged for 60
days after that  closing  (I.E.,  at no time during  that  60-day  period is the
Fund's  risk of loss  regarding  that  position  reduced  by reason  of  certain
specified   transactions  with  respect  to  substantially  similar  or  related
property,  such as having an option to sell,  being  contractually  obligated to
sell, making a short sale or granting an option to buy  substantially  identical
stock or securities).

TAX TREATMENT OF SHAREHOLDERS

Dividends from the Fund's investment company taxable income (whether received in
cash  or  reinvested  in  additional   Shares)  generally  are  taxable  to  its
shareholders  as  ordinary  income to the extent of its  earnings  and  profits.
Distributions  of the Fund's  net  capital  gain  (whether  received  in cash or
reinvested in additional  Shares),  when  designated as such, are taxable to its
shareholders  as long-term  capital gain,  regardless of how long they have held
their Shares. A participant in the Dividend  Reinvestment and Cash Purchase Plan
("Reinvestment  Plan") will be treated as having  received a distribution in the
amount of the cash used to purchase Shares on his or her behalf, including a PRO
RATA portion of the brokerage fees incurred by the agent under the  Reinvestment
Plan.  Distributions by the Fund to its shareholders in any year that exceed its
earnings and profits  generally may be applied by each  shareholder  against the
basis for his or her Shares and will be taxable at capital gains rates (assuming
the  Shares  are held as a capital  asset) to a  shareholder  to the  extent the
distributions to the shareholder  exceed the shareholder's  basis for his or her
Shares. Shareholders who are not liable for tax on their income and whose Shares
are not  debt-financed  generally  are not  required to pay tax on  dividends or
other distributions they receive from the Fund.

A portion of the dividends  from the Fund's  investment  company  taxable income
(whether paid in cash or  reinvested  in additional  Shares) may be eligible for
the dividends-received  deduction allowed to corporations.  The eligible portion
may  not  exceed  the  aggregate  dividends  the  Fund  receives  from  domestic
corporations.  However,  dividends  received  by  a  corporate  shareholder  and
deducted  by  it  pursuant  to  the  dividends-received  deduction  are  subject
indirectly  to the  federal  alternative  minimum  tax.  The  Fund  will  notify
shareholders  of the amount of any dividends  that may be taken into account for
purposes of the  dividends-received  deduction  not later than 60 days after the
close of its taxable year.

The Fund may retain its net capital  gain for  investment.  If the Fund does so,
however,  it will be subject  to a tax of 35% on the  retained  amount.  In that
event,  the Fund  expects to  designate  the  retained  amount as  undistributed
capital  gains in a notice  to its  shareholders,  who (1) will be  required  to
include in their taxable income, as long-term capital gain, their  proportionate
shares  of  the  retained   amount,   (2)  will  be  entitled  to  credit  their
proportionate  shares of the tax paid by the Fund against their  federal  income
tax liabilities and, for any shareholder  whose share of that tax exceeds his or
her tax liabilities,  to claim a refund,  and (3) will increase the tax basis of
their Shares by the difference between the included income and such share of the
Fund tax.

The Fund will notify its shareholders following the end of each calendar year of
the amounts of dividends  and capital gain  distributions  paid (or deemed paid)
that year and undistributed capital gain designated for that year.

Investors should be aware that if Shares are purchased shortly before the record
date for any  dividend or other  distribution,  they will pay full price for the
Shares and will receive  some  portion of the  purchase  price back as a taxable
distribution.



                                       25
<PAGE>

On the  sale  or  exchange  of  Shares  (including  a sale  pursuant  to a Share
repurchase or tender offer by the Fund), a shareholder  generally will recognize
a taxable gain or loss equal to the difference between his or her adjusted basis
for the Shares and the amount received. Any such gain or loss will be treated as
a capital  gain or loss if the  Shares  are held by the  shareholder  as capital
assets and will be  long-term  capital gain or loss if the Shares have been held
for more than one year. Any loss recognized on a sale or exchange of Shares that
were held for six  months or less will be  treated  as  long-term,  rather  than
short-term,  capital  loss  to the  extent  of any  capital  gain  distributions
previously  received  thereon.  A loss  realized on a sale or exchange of Shares
will be  disallowed  to the extent  those  Shares are  replaced by other  Shares
within a period of 61 days beginning 30 days before and ending 30 days after the
date of disposition of the Shares (which could occur,  for example,  as a result
of  participation  in the  Reinvestment  Plan). In that event,  the basis of the
replacement Shares will be adjusted to reflect the disallowed loss.

Net capital gain recognized by individuals and other non-corporate  taxpayers on
the sale or  exchange of capital  assets held for one year or less,  and all net
capital gain recognized by corporations,  is taxed at the same rates as ordinary
income. The maximum tax rate applicable to non-corporate  taxpayers' net capital
gain for capital  assets held longer than one year is 20% (10% for  taxpayers in
the 15% marginal tax bracket); this rate applies to distributions of net capital
gain by the Fund as well as to sales and exchanges of Shares.

                              FINANCIAL STATEMENTS

PricewaterhouseCoopers  LLP are the  Fund's  independent  accountants  providing
audit and tax return  preparation  services and assistance and  consultation  in
connection   with  the  review  of  various   SEC   filings.   The   address  of
PricewaterhouseCoopers  LLP is 950 Seventeenth Street, Denver, Colorado,  80202.
The  financial  statements  incorporated  by  reference in this SAI have been so
incorporated and the financial  highlights  included in the Prospectus have been
so included, in reliance upon the report of PricewaterhouseCoopers  LLP given on
the authority of said firm as experts in accounting and auditing.

                           INCORPORATION BY REFERENCE

The Fund's  Annual  Report  for the fiscal  year  ended  October  31,  1998 (the
"Report"),  which either accompanies this SAI or has previously been provided to
the person to whom this SAI is being sent, is  incorporated  herein by reference
with  respect to all  information  other than the  information  set forth in the
Letter to Shareholders included therein. The Fund will furnish,  without charge,
a copy of its Report upon  written  request to INVESCO  Global  Health  Sciences
Fund, 7800 East Union Avenue, Denver, Colorado 80237, or call 1-800-528-8765, or
visit our website at http://ghs.invesco.com.


                                       26
<PAGE>

                            PART C OTHER INFORMATION

ITEM 24.  FINANCIAL STATEMENTS AND EXHIBITS

1.  Financial Statements

      (a) Financial Highlights - Contained in Part A

      (b) Incorporated in  Part B by reference to Registrant's  October 31, 1998
          Annual Report:

          1.  Statement of Investments as of October 31, 1998

          2.  Statement of Assets and Liabilities as of October 31, 1998

          3.  Statement of Operations for the years ended October 31, 1998
              and October 31, 1997

          4.  Statements  of Changes in Net Assets for the year ended  October
              31, 1998

          5.  Statement of Cash Flows for the year ended October 31, 1998

          6.  Notes to Financial Statements

          7.  Financial Highlights

          8.  Report of Independent Accountants dated December 8, 1998

2.  Exhibits*

      (a)(1) Declaration of Trust of the Registrant

      (a)(2) Amendment of the Declaration of Trust of the Registrant

      (b)    By-Laws of the Registrant

      (c)    Not Applicable

      (d)(1) Specimen Certificate for Shares of Beneficial Interest of the
             Registrant*

      (d)(2) Form of Subscription Certificate*

      (d)(3) Form of Notice of Guaranteed Delivery*

      (d)(4) Form of Nominee Holder Over-Subscription Exercise Form*

      (d)(5) Form of Beneficial Owner Listing Certification*

      (e)    Dividend Reinvestment and Cash Purchase Plan of the Registrant

      (f)    Not Applicable

      
                                       27
<PAGE>
      (g)(1) Investment Management Agreement between the Registrant and INVESCO
             Funds Group, Inc.

      (g)(2) Amendment to Investment Management Agreement

      (h)    Form of Underwriter Agreement between the Registrant and
             PaineWebber Incorporated*

      (i)(1) Deferred Fee Agreement

      (i)(2) Defined Benefit Deferred Compensation Plan for Non-Interested
             Directors and Trustees

      (j)(1) Custody Agreement between the Registrant and State Street Bank
             and Trust Company

      (j)(2) Special Custody Account Agreement between the Registrant and
             Bear Stearns Securities Corp.

      (j)(3) Special  Custody  Account  Agreement  between the Registrant and
             Herzog, Heine, Geduld

      (k)(1) Registrar, Transfer Agency and Service Agreement between the 
             Registrant and State Street Bank and Trust Company

      (k)(2) Administration Agreement between the Registrant and INVESCO Funds
             Group Inc.

      (k)(3) Amendment to Administration Agreement

      (k)(4) Form of Subscription Agreement with INVESCO Funds Group, Inc.*

      (l)    Opinion and Consent of Kirkpatrick & Lockhart LLP*

      (m)    Not Applicable

      (n)    Consent of PricewaterhouseCoopers LLP*

      (o)    Not Applicable

      (p)    Subscription Agreement for Initial Capital*

      (q)    Not Applicable

      (r)    Financial Data Schedule*

      (s)    Powers of Attorney*

      *to be completed by Amendment

ITEM 25.  MARKETING AGREEMENTS

      See Form of Dealer  Manager  Agreement  to be filed as Exhibit (h) to this
Registration Statement.



                                       28
<PAGE>

ITEM 26.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION*

      Registration Fees....................................................
      Printing and Engraving Expenses......................................
      Rating Agency Fees and Expenses......................................
      Trustees' Fees and Expenses..........................................
      Legal Fees and Expenses..............................................
      New York Stock Exchange Listing Fees.................................
      National Association of Securities Dealers, Inc. Fees................
      Accounting Fees and Expenses.........................................
      Dealer Manager Expense Reimbursement.................................
      Subscription Agent Fees and Expenses.................................
      Information Agent's Fees and Expenses................................
      Federal Taxes........................................................
      State Taxes..........................................................
      State Fees...........................................................
      Miscellaneous Expenses...............................................
      Total................................................................

      *to be completed by Amendment

ITEM 27.  PERSONS CONTROLLED BY OR UNDER COMMON CONTROL

      Not Applicable.

ITEM 28.  NUMBER OF HOLDERS OF SECURITIES

                                                        NUMBER OF RECORD HOLDERS
               TITLE OF CLASS                            AS OF [         ]  1999
               --------------                            ------------------
               Shares of Beneficial Interest.........            [XXX]

ITEM 29.  INDEMNIFICATION

Section 5.3 of the Registrant's  Declaration of Trust (Exhibit (a) hereto, which
is incorporated by reference herein) provides in effect that the Registrant will
indemnify its officers and Trustees  under certain  circumstances.  However,  in
accordance  with Section 17(h) and 17(i) of the  Investment  Company Act of 1940
and its own terms,  said Article of the Agreement and  Declaration of Trust does
not  protect  any  person  against  any  liability  to  the  Registrant  or  its
shareholders  to which he would  otherwise  be  subject  by reason of bad faith,
willful  misfeasance,  gross  negligence,  or reckless  disregard  of the duties
involved in the conduct of his office.

Insofar as indemnification  for liabilities  arising under the Securities Act of
1933 may be  permitted  to Trustees,  officers  and  controlling  persons of the
Registrant,  pursuant to the foregoing  provisions or otherwise,  the Registrant
has been advised that in the opinion of the SEC, such indemnification is against
public policy as expressed in the Act and is, therefore,  unenforceable.  In the
event that a claim for indemnification  against such liabilities (other than the
payment by the Registrant of expenses incurred or paid by a Trustee,  officer or
controlling  person of the Registrant in the  successful  defense of any action,
suit or proceeding) is asserted by such Trustee,  officer or controlling  person
in connection with the securities being registered,  the Registrant will, unless
in the  opinion  of its  counsel  the matter  has been  settled  by  controlling
precedent,  submit to a court of  appropriate  jurisdiction  the  question as to


                                       29
<PAGE>


whether such  indemnification by it is against public policy as expressed in the
Act and will be governed by the final adjudication of such issue.

ITEM 30.  BUSINESS AND OTHER CONNECTIONS OF INVESTMENT MANAGER

The description of the business of INVESCO Funds Group,  Inc. is set forth under
the caption  "Management  of the Fund" in the Prospectus and SAI forming part of
this Registration Statement.

The  information  as to the Directors and officers of INVESCO Funds Group,  Inc.
set forth in  INVESCO  Funds  Group's  Form ADV filed  with the  Securities  and
Exchange Commission (File No. 811-6476), as  amended through the date hereof, is
incorporated herein by reference.

ITEM 31.  LOCATION OF ACCOUNTS AND RECORDS

INVESCO Global Health  Sciences Fund, 7800 East Union Avenue,  Denver,  Colorado
80237, or call  1-800-528-8765.  Accounts and Records of the Fund are maintained
at (i) the Fund's office at 7800 East Union, Avenue, Denver, Colorado, 80237 and
(ii) the  offices of INVESCO  Funds  Group,  Inc.  at 7800 East  Union,  Avenue,
Denver, Colorado, 80237.

In addition,  EquiServe, Inc., 150 Royall Street, Canton, MA 02021 maintains all
the  required  records  in  its  capacity  as  transfer,  dividend  paying,  and
shareholder service agent of the Registrant.

ITEM 32.  MANAGEMENT SERVICES

      Not Applicable.

ITEM 33.  UNDERTAKINGS

1. The  Registrant  undertakes  to suspend  the Offer  until the  Prospectus  is
amended if (1) subsequent to the effective date of this registration  statement,
the NAV declines more than ten percent from its NAV as of the effective  date of
this registration statement or (2) the NAV of the Shares exercisable pursuant to
the Rights that are the subject of this registration  statement  increases to an
amount  greater  than the net proceeds as stated in the  Prospectus  included in
this registration statement.

2.  Not Applicable.

3.  Not Applicable.

4.  Not Applicable.

5.  The Registrant undertakes:

       a. for the purpose of determining  any liability under the Securities Act
      of 1933, the information omitted from the form of prospectus filed as part
      of this registration statement in reliance upon Rule 430A and contained in
      a form of prospectus  filed by the Registrant  under Rule 497(h) under the
      Securities  Act of 1933  shall be deemed  to be part of this  registration
      statement as of the time it was declared effective; and

       b. for the purpose of determining any liability under the Securities Act,
      each post-effective  amendment that contains a form of prospectus shall be
      deemed  to be a new  registration  statement  relating  to the  securities

                                       30
<PAGE>



      offered therein,  and the offering of the securities at that time shall be
      deemed to be the initial bona fide offering thereof.

6. The Registrant undertakes to send by first class mail or other means designed
to ensure  equally  prompt  delivery,  within two Business  Days of receipt of a
written or oral request, any SAI.



                                       31
<PAGE>

SIGNATURES  Pursuant to the  requirements  of the Securities Act of 1933 and the
Investment Company Act of 1940, the Registrant has duly caused this Registration
Statement  to  be  signed  on  its  behalf  by  the  undersigned,  thereto  duly
authorized, in the City of Denver, State of Colorado on APRIL 7, 1999.

 INVESCO GLOBAL HEALTH SCIENCES FUND

 By:  /s/ Mark H. Williamson       April 7, 1999
      ------------------------------------------
      Mark H.  Williamson              DATE
      President


Pursuant to the  requirements of the Securities Act of 1933,  this  Registration
Statement  has been  signed  below by the  following  persons in the  capacities
indicated on the dates indicated.  The undersigned hereby constitute and appoint
Glen A. Payne,  [Clifford  J.  Alexander,  Robert H.  Rosenblum,  and Anthony S.
Higgins,] and each of them, with full power to act without the other, his or her
true and lawful attorney-in-fact and agent, with full power and substitution and
resubstitution,  for him or her, and in his or her name, place and stead, in any
and all capacities  (until revoked in writing) to sign any and all amendments to
the  Registration  Statement  of  the  INVESCO   Global   Health   Sciences Fund
(including  post-effective  amendments  thereto),  and  to file  the same,  with
all exhibits thereto, and other documents in connection therewith, with the SEC,
granting unto said  attorneys-in  fact and agents,  and each of them, full power
and  authority  to do and  perform  each and every act and thing  ratifying  and
confirming all that said  attorneys-in  fact and agents or any of them, or their
or his or her substitute or substitutes,  may lawfully do or cause to be done by
virtue hereof.


By:   /s/ Mark H. Williamson            April 7, 1999
      -----------------------------------------------
      Principal Executive Officer,           DATE
      Mark H.  Williamson, President


By:   /s/ Ronald L. Grooms              April 7, 1999
      -----------------------------------------------
      Principal Financial Officer,           DATE
      Ronald L.  Grooms Vice President and Treasurer


By:   /s/ John R. Schroer               April 7, 1999
      -----------------------------------------------
      Vice President                         DATE
      John R.  Schroer


By:   /s/ Glen A. Payne                 April 7, 1999
      -----------------------------------------------
      Secretary                              DATE
      Glen A.  Payne


By:   *                                 April 7, 1999
      -----------------------------------------------
      Trustee                                DATE
      Charles W.  Brady


                                       32
<PAGE>

By:   *                                 April 7, 1999
      -----------------------------------------------
      Trustee                                DATE
      Fred A.  Deering


By:   *                                 April 7, 1999
      -----------------------------------------------
      Trustee                                DATE
      John W.  McIntyre


By:   *                                 April 7, 1999
      -----------------------------------------------
      Trustee                                DATE
      Dr.  Larry Soll



*By:   /s/ Glen A. Payne                 April 7, 1999
      -----------------------------------------------
      Glen A. Payne                          DATE
      Attorney in Fact for the Trustees



                                       33
<PAGE>

                                INDEX OF EXHIBITS


(2)(a)(1)  Declaration of Trust of the Registrant
(2)(a)(2)  Amendment to the Declaration of Trust of the Registrant
(2)(b)     By-Laws of the Registrant
(2)(e)     Dividend Reinvestment and Cash Purchase Plan of the Registrant
(2)(g)(1)  Investment Advisory Agreement between the Registrant and INVESCO
           Funds Group, Inc.
(2)(g)(2)  Amendment to Advisory Agreement
(2)(i)(1)  Deferred Fee Agreement
(2)(i)(2)  Defined Benefit Deferred Compensation Plan for Non-Interested
           Directors and Trustees
(2)(j)(1)  Custodian Contract between the Registrant and State Street Bank and
           Trust Company
(2)(j)(2)  Special Custody Account Agreement between the Registrant and Bear,
           Stearns Securities Corp.
(2)(j)(3)  Special Custody Account Agreement between the Registrant and Herzog,
           Heine, Geduld, Inc.
(2)(k)(1)  Registrar, Transfer Agency and Service Agreement between the
           Registrant and State Street Bank and Trust Company
(2)(k)(2)  Administration Agreement between the Registrant and INVESCO Funds
           Group, Inc.
(2)(k)(3)  Amendment to Administration Agreement



                              DECLARATION OF TRUST

                                       OF

                         THE GLOBAL HEALTH SCIENCES FUND


                            Dated: November 18, 1991





<PAGE>


                                TABLE OF CONTENTS


                                                                            PAGE

ARTICLE I  -  NAME AND DEFINITIONS...........................................1
      Section 1.1  Name......................................................1
      Section 1.2  Definitions...............................................1

ARTICLE II  -  TRUSTEES......................................................3
      Section 2.1  Number of Trustees........................................3
      Section 2.2  Term of Office of Trustees................................3
      Section 2.3  Resignation and Appointment of Trustees...................4
      Section 2.4  Vacancies.................................................4
      Section 2.5  Delegation of Power to Other Trustees.....................5
      Section 2.6  Removal of Trustees.......................................5

ARTICLE III  -  POWER OF TRUSTEES............................................5
      Section 3.1  General...................................................5
      Section 3.2  Investments...............................................6
      Section 3.3  Legal Title...............................................6
      Section 3.4  Issuance and Repurchase of Securities.....................7
      Section 3.5  Borrowing Money; Lending Fund Assets......................7
      Section 3.6  Delegation; Committees....................................7
      Section 3.7  Collection and Payment....................................7
      Section 3.8  Expenses..................................................7
      Section 3.9  Manner of Acting; By-Laws.................................7
      Section 3.10  Miscellaneous Powers.....................................8
      Section 3.11  Principal Transactions...................................8
      Section 3.12  Litigation...............................................8
      Section 3.13  Trustees and Officers as Shareholders....................9

ARTICLE IV  -  INVESTMENT ADVISER, DISTRIBUTOR,
               CUSTODIAN AND TRANSFER AGENT..................................9
      Section 4.1 Investment Adviser.........................................9
      Section 4.2  Administrative Services...................................9
      Section 4.3  Distributor..............................................10
      Section 4.4  Transfer Agent...........................................10
      Section 4.5  Custodian................................................10
      Section 4.6  Parties to Contract......................................10

ARTICLE V  -   LIMITATIONS OF LIABILITY OF SHAREHOLDERS,
               TRUSTEES AND OTHERS..........................................11
      Section 5.1  No Personal Liability of Shareholders, Trustees, etc.....11
      Section 5.2  Non-Liability of Trustees, etc...........................11
      Section 5.3  Indemnification..........................................11


                                       -i-
<PAGE>


      Section 5.4 No Bond Required of Trustees..............................12
      Section 5.5  No Duty of Investigation; Notice in Fund Instruments, etc12
      Section 5.6  Reliance on Experts, etc.................................12

ARTICLE VI  -  SHARES OF BENEFICIAL INTEREST................................13
      Section 6.1  Beneficial Interest......................................13
      Section 6.2  Rights of Shareholders...................................13
      Section 6.3  Trust Only...............................................13
      Section 6.4  Issuance of Shares.......................................13
      Section 6.5  Register of Shares.......................................14
      Section 6.6  Transfer of Shares.......................................14
      Section 6.7  Notices..................................................14
      Section 6.8  Voting Powers............................................15

ARTICLE VII   -   DETERMINATION OF NET ASSET VALUE,
                  NET INCOME AND DISTRIBUTIONS..............................15
      Section 7.1  Net Asset Value..........................................15
      Section 7.2  Distributions to Shareholders............................15
      Section 7.3  Determination of Net Income..............................16
      Section 7.4  Power to Modify Foregoing Procedures.....................16

ARTICLE VIII   -  DURATION; TERMINATION OF FUND;
                  AMENDMENT; MERGERS, ETC...................................16
      Section 8.1  Duration.................................................16
      Section 8.2  Termination of Fund......................................17
      Section 8.3  Amendment Procedures.....................................17
      Section 8.4  Merger, Consolidation and Sale of Assets.................18
      Section 8.5  Incorporation and Reorganization.........................19
      Section 8.6  Conversion...............................................19
      Section 8.7  Certain Transactions.....................................19

ARTICLE IX -  REPORTS TO SHAREHOLDERS.......................................21

ARTICLE X  -  MISCELLANEOUS.................................................21
      Section 10.1  Filing..................................................21
      Section 10.2  Resident Agent..........................................22
      Section 10.3  Governing Law...........................................22
      Section 10.4  Organizational Expenses.................................22
      Section 10.5  Counterparts............................................22
      Section 10.6  Reliance by Third Parties...............................22
      Section 10.7  Provisions in Conflict with Law or Regulations..........22


                                      -ii-
<PAGE>


                              DECLARATION OF TRUST

                                       OF

                         THE GLOBAL HEALTH SCIENCES FUND

                            Dated: November 18, 1991

                        --------------------------------


            THIS DECLARATION OF TRUST of The Global Health Sciences Fund is made
the 18th day of  November,  1991 by the parties  signatory  hereto,  as Trustees
(such persons,  so long as they shall continue in office in accordance  with the
terms of this  Declaration  of Trust,  and all other  persons who at the time in
question have been duly elected or appointed as Trustees in accordance  with the
provisions  of  this  Declaration  of  Trust  and  are  then  in  office,  being
hereinafter called the "Trustees").

                            W I T N E S S E T H :
                            - - - - - - - - - -

            WHEREAS,  the  Trustees  desire  to form a Trust  under  the laws of
Massachusetts for the investment and reinvestment of funds contributed  thereto;
and

            WHEREAS,  it is provided that the  beneficial  interest in the Trust
assets be divided into transferable shares of beneficial interest as hereinafter
provided;

            NOW,  THEREFORE,  the Trustees hereby declare that they will hold in
trust all money and property  contributed  to the Trust to manage and dispose of
the same for the  benefit  of the  holders  from  time to time of the  shares of
beneficial  interest issued hereunder and subject to the provisions  hereof,  to
wit:

                                    ARTICLE I

                              NAME AND DEFINITIONS
                              --------------------

            SECTION 1.1 NAME.  The name of the Trust created  hereby is the "The
Global  Health  Sciences  Fund," and so far as may be  practicable  the Trustees
shall conduct the Trust's  activities,  execute all documents and sue or be sued
under that name,  which name (and the word "Fund"  wherever  herein  used) shall
refer to the Trustees as trustees,  and not as  individuals,  or personally  and
shall not refer to the officers,  agents, employees or Shareholders of the Fund.
Should the Trustees  determine that the use of such name is not advisable,  they
may use such other  name for the Fund as they deem  proper and the Fund may hold
its property and conduct its activities under such other name.

            SECTION  1.2  DEFINITIONS.   Wherever  they  are  used  herein,  the
following terms have the following respective meanings:


<PAGE>


            (a)   "BY-LAWS" means the By-Laws referred to in Section 3.9 hereof,
                  as from time to time amended.

            (b)   The terms  "COMMISSION,"  "AFFILIATED  PERSON" and "INTERESTED
                  PERSON" have the meanings given them in the 1940 Act.

            (c)   "DECLARATION"  means this Declaration of Trust as amended from
                  time to  time.  Reference  in this  Declaration  of  Trust  to
                  "DECLARATION,"  "HEREOF,"  "HEREIN" and  "HEREUNDER"  shall be
                  deemed to refer to this Declaration rather than the article or
                  section in which such words appear.

            (d)   "DISTRIBUTOR"  means the  party,  other  than the  Fund,  to a
                  contract described Section 4.3 hereof.

            (e)   "FUND" means The Global Health Sciences Fund.

            (f)   "FUND PROPERTY" means any and all property,  real or personal,
                  tangible or  intangible,  which is owned or held by or for the
                  account of the Fund or the Trustees.

            (g)   "FUNDAMENTAL  POLICIES" shall mean the investment policies and
                  restrictions  set  forth  in the  Registration  Statement  and
                  designated as fundamental policies herein.

            (h)   "INVESTMENT  ADVISER" means any party, other than the Fund, to
                  a contract described in Section 4.1 hereof.

            (i)   "MAJORITY SHAREHOLDER VOTE" means the vote of the holders of a
                  majority of Shares,  which shall  consist of (i) a majority of
                  Shares presented in person or by proxy and entitled to vote at
                  a meeting of Shareholders at which a quorum,  as determined in
                  accordance with the By-Laws,  is present or (ii) a majority of
                  Shares issued and outstanding and entitled to vote when action
                  is taken by written consent of Shareholders, unless the action
                  requires the approval of a "majority of the outstanding voting
                  securities"  under  the 1940 Act,  in which  case such vote as
                  specified in the 1940 Act shall be required.

            (j)   "1940 ACT" means the  Investment  Company  Act of 1940 and the
                  rules and regulations thereunder as amended from time to time.

            (k)   "PERSON"   means  and  includes   individuals,   corporations,
                  partnerships,  trusts, associations,  joint ventures and other
                  entities,  whether or not legal entities,  and governments and
                  agencies and political subdivisions thereof.

            (l)   "REGISTRATION  STATEMENT" means the Registration  Statement of
                  the Fund under the Securities Act of 1933 as such Registration
                  Statement  may be amended and filed with the  Commission  from
                  time to time.


                                      -2-
<PAGE>


            (m)   "SHAREHOLDER" means a record owner of outstanding Shares.

            (n)   "SHARES" means the units of interest into which the beneficial
                  interest  in the Fund shall be  divided  from time to time and
                  includes fractions of Shares as well as whole Shares.

            (o)   "TRANSFER AGENT" means the party,  other than the Fund, to the
                  contract described in Section 4.4 hereof.

            (p)   "TRUSTEES"  means the  persons  who have  signed the  --------
                  Declaration,  so long as they  shall  continue  in  office  in
                  accordance  with the terms  hereof,  and all other persons who
                  may from time to time be duly elected or appointed,  qualified
                  and  serving as  Trustees in  accordance  with the  provisions
                  hereof,  and  reference  herein to a Trustee  or the  Trustees
                  shall  refer to such  person or persons in their  capacity  as
                  Trustees hereunder.

                                   ARTICLE II

                                    TRUSTEES
                                    --------

            SECTION 2.1 NUMBER OF TRUSTEES. The number of Trustees shall be such
number as shall be fixed from time to time by a written  instrument  signed by a
majority of the Trustees,  provided,  however, that the number of Trustees shall
in no event be less than three (3) nor more than fifteen  (15).  No reduction in
the number of Trustees shall have the effect of removing any Trustee from office
prior to the expiration of his term unless the Trustee is  specifically  removed
pursuant to Section 2.2 of this Article II at the time of decrease.

            SECTION 2.2 TERM OF OFFICE OF TRUSTEES.  The Board of Trustees shall
be divided into four classes.  Within the limits above specified,  the number of
the Trustees in each class shall be  determined  by  resolution  of the Board of
Trustees.  The term of office of all of the Trustees shall expire on the date of
the first annual or special meeting of shareholders following the effective date
of the Registration Statement relating to the Shares under the Securities Act of
1933, as amended. The term of office of the first class shall expire on the date
of the second annual meeting of shareholders or special meeting in lieu thereof.
The term of office of the  second  class  shall  expire on the date of the third
annual meeting of shareholders  or special meeting in lieu thereof.  The term of
office of the third class shall expire on the date of the fourth annual  meeting
of shareholders  or special  meeting in lieu thereof.  The term of office of the
fourth  class  shall  expire  on  the  date  of  the  fifth  annual  meeting  of
shareholders or special meeting in lieu thereof.  Upon expiration of the term of
office of each class as set forth  above,  the number of Trustees in such class,
as determined by the Board of Trustees,  shall be elected for a term expiring on
the date of the fourth annual meeting of shareholders or special meeting in lieu
thereof  following such expiration to succeed the Trustees whose terms of office
expire.  The Trustees shall be elected at an annual meeting of the  shareholders


                                      -3-
<PAGE>


or special  meeting in lieu thereof called for that purpose,  except as provided
in Section 2.3 of this Article and each Trustee  elected shall hold office until
his successor shall have been elected and shall have qualified;  except (a) that
any  Trustee  may  resign  his  trust  (without  need for  prior  or  subsequent
accounting)  by an instrument in signed by him or her and delivered to the other
Trustees,  which shall take effect upon such delivery or upon such later date as
is  specified  therein;  (b) that  any  Trustee  may be  removed  (provided  the
aggregate  number of  Trustees  after  such  removal  shall not be less than the
number  required  by Section  2.1  hereof)  with  cause,  at any time by written
instrument,  signed by the  remaining  Trustees,  specifying  the date when such
removal shall become effective; and (c) that any Trustee who requests in writing
to be  retired  or who has  become  incapacitated  by  illness  or injury may be
retired  by  written  instrument  signed by a  majority  of the other  Trustees,
specifying  the date of his  retirement.  Upon the  resignation  or removal of a
Trustee,  or his otherwise  ceasing to be Trustee,  he shall execute and deliver
such  documents  as the  remaining  Trustees  shall  require  for the purpose of
conveying to the Fund or the  remaining  Trustees any Fund  Property held in the
name of the resigning or removed  Trustee.  Upon the  incapacity or death of any
Trustee,  his legal  representative shall execute and deliver on his behalf such
documents as the remaining  Trustees  shall require as provided in the preceding
sentence.

            SECTION 2.3 RESIGNATION AND APPOINTMENT OF TRUSTEES.  In case of the
declaration, death, resignation,  retirement, removal or inability of any of the
Trustees,  or in case a vacancy shall,  by reason of any increase in number,  or
for any other  reason,  exist,  the  remaining  Trustees or, prior to the public
offering of Shares of the Fund, if only one Trustee shall then remain in office,
the remaining  Trustee,  shall fill such vacancy by appointing such other person
as they or any one of them, in their discretion, shall see fit. Such appointment
shall be evidenced by a written instrument signed by a majority of the remaining
Trustees or by the remaining  Trustee,  as the case may be. Any such appointment
shall not  become  effective,  however,  until the person  named in the  written
instrument or appointment  shall have accepted in writing such  appointment  and
agreed in writing  to be bound by the terms of the  Declaration.  Within  twelve
months of such appointment,  the Trustees shall cause notice of such appointment
to be mailed to each  Shareholder at his or her address as recorded on the books
of the Fund.  An  appointment  of a Trustee may be made by the Trustees  then in
office and notice thereof mailed to Shareholders as aforesaid in anticipation of
a vacancy to occur by reason of retirement, resignation or increase in number of
Trustees effective at a later date,  provided that said appointment shall become
effective only at or after the effective date of said retirement, resignation or
increase  in number of  Trustees.  The power of  appointment  is  subject to the
provisions of Section 16(a) of the 1940 Act.

            SECTION  2.4  VACANCIES.   The  death,   declination,   resignation,
retirement, removal or incapacity of the Trustees, or any one of them, shall not
operate to annul the Fund or to revoke any existing  agency created  pursuant to
the terms of this  Declaration.  Whenever a vacancy  in the  number of  Trustees
shall  occur,  until such  vacancy is filled as  provided  in Section  2.3,  the
Trustees  in  office,  regardless  of their  number,  shall  have all the duties
imposed upon the Trustees by the Declaration.  A written  instrument  certifying
the  existence  of such vacancy  signed by a majority of the  Trustees  shall be
conclusive evidence of the existence of such vacancy.

            SECTION 2.5  DELEGATION OF POWER TO OTHER  TRUSTEES.  Subject to the
provisions of the 1940 Act, any Trustee may, by power of attorney,  delegate his
or her power for a period  not  exceeding  six (6) months at any one time to any
other  Trustee  or  Trustees;  provided  that in no case shall less than two (2)
Trustees  personally  exercise  the  powers  granted to the  Trustees  under the
Declaration except as herein otherwise expressly provided.


                                      -4-
<PAGE>


            SECTION  2.6  REMOVAL OF  TRUSTEES.  The Fund shall  comply with the
provisions  of Section  16(c) of the 1940 Act as though  applicable to the Fund,
and with  interpretations  thereof  by the  Commission  staff,  insofar  as such
provisions and interpretations provide for the removal of trustees of common-law
trusts and the  calling of  Shareholder  meetings  for such  purpose;  provided,
however,  that  the  Fund  may at any  time or from  time to time  apply  to the
Commission for one or more  exemptions from all or part of said Section 16(c) or
a staff  interpretation  thereof and, if exemptive order(s) or interpretation(s)
are  issued or  provided  by the  Commission  or its  staff,  such  order(s)  or
interpretation(s)  shall be deemed  part of Section  16(c) for the  purposes  of
applying this Section 2.6.


                                   ARTICLE III

                                POWER OF TRUSTEES
                                -----------------

            SECTION 3.1 GENERAL.  The Trustees shall have exclusive and absolute
control  over the Fund  Property  and over the  business of the Fund to the same
extent as if the Trustees were the sole owners of the Fund Property and business
in their own right,  but with such powers of  delegation  as may be permitted by
the  Declaration.  The Trustees  shall have power to conduct the business of the
Fund and carry on its  operations  in any and all of its  branches  and maintain
offices both within and without the  Commonwealth of  Massachusetts,  in any and
all states of the United States of America, in the District of Columbia,  and in
any and all commonwealths,  territories,  dependencies,  colonies,  possessions,
agencies or  instrumentalities  wheresoever in the world they may be located and
to do all such  other  things  and  execute  all such  instruments  as they deem
necessary,  proper or  desirable  in order to promote the  interests of the Fund
although such things are not herein specifically mentioned. Any determination as
to what is in the interests of the Fund made by the Trustees in good faith shall
be conclusive. In construing the provisions of the Declaration,  the presumption
shall be in favor of a grant of power to the Trustees.

            The  enumeration of any specific power herein shall not be construed
as limiting the  aforesaid  power.  Such powers of the Trustees may be exercised
without order of or resort to any court.

            SECTION 3.2  INVESTMENTS.  The Trustees shall have the power to:
            ------------------------

            (a)   conduct,  operate and carry on the  business of an  investment
                  company;

            (b)   subscribe for,  invest in,  reinvest in, purchase or otherwise
                  acquire,  hold, pledge,  sell, sell short,  assign,  transfer,
                  exchange,  distribute, lend or otherwise deal in, all forms of
                  securities of every kind,  nature,  character,  type and form,
                  and other financial  instruments  that may not be deemed to be
                  securities,  including,  but not limited to, futures contracts
                  and options thereon,  forward foreign currency contracts,  and
                  equity swaps. Such securities and other financial  instruments


                                      -5-
<PAGE>

                  may include,  but are not limited to, shares,  stocks,  bonds,
                  debentures,  notes, scrip, participation certificates,  rights
                  to  subscribe,   warrants,   options,  repurchase  agreements,
                  commercial paper,  evidences of indebtedness,  certificates of
                  indebtedness,  issued  or to be  issued  by  any  corporation,
                  company, partnership,  association, trust or entity, public or
                  private,  engaged in the health  sciences,  whether  organized
                  under  the  laws  of  the   United   States,   or  any  state,
                  commonwealth,  territory  or  possession  thereof,  or of  any
                  foreign  country,  or  any  state,   province,   territory  or
                  possession thereof; and to exercise any and all rights, powers
                  and privileges of ownership or interest in respect of any kind
                  all such investments of every kind and description, including,
                  without  limitation,  the right to consent and  otherwise  act
                  with  respect  thereto,  with power to  designate  one or more
                  persons,  firms,  associations or corporations to exercise any
                  of said  rights,  powers and  privileges  in respect of any of
                  said instruments;  and the Trustee shall be deemed to have the
                  foregoing powers with respect to any additional  securities in
                  which the Fund may invest should the  Fundamental  Policies be
                  amended.

The Trustees  shall not be limited to investing in obligations  maturing  before
the possible  termination  of the Fund, nor shall the Trustees be limited by any
law limiting the investments which may be made by fiduciaries.

            SECTION 3.3 LEGAL TITLE.  Legal title to all the Fund Property shall
be vested in the Trustees as joint tenants  except that the Trustees  shall have
power to cause legal title to any Fund  Property to be held by or in the name of
one or more of the  Trustees,  or in the name of the Fund, or in the name of any
other Person as nominee,  on such terms as the Trustees may determine,  provided
that the interest of the Fund  therein is  appropriately  protected.  The right,
title and interest of the Trustees in the Fund Property shall vest automatically
in each Person who may hereafter become a Trustee. Upon the resignation, removal
or death of a Trustee  he or she shall  automatically  cease to have any  right,
title or interest in any of the Fund Property, and the right, title and interest
of such Trustee in the Fund Property shall vest  automatically  in the remaining
Trustees.  Such vesting and cessation of title shall be effective whether or not
conveyancing documents have been executed and delivered.

            SECTION 3.4  ISSUANCE AND  REPURCHASE  OF  SECURITIES.  The Trustees
shall have the power to issue, sell, repurchase,  retire, cancel, acquire, hold,
resell, reissue, dispose of, transfer, and otherwise deal in Shares and, subject
to the  provisions  set forth in Articles VII and VIII  hereof,  to apply to any
such repurchase, retirement,  cancellation or acquisition of Shares any funds or
property  of the Fund,  whether  capital or surplus  or  otherwise,  to the full
extent  now  or  hereafter   permitted  by  the  laws  of  the  Commonwealth  of
Massachusetts governing business corporations.

            SECTION 3.5  BORROWING  MONEY;  LENDING FUND ASSETS.  Subject to the
Fundamental  Policies,  the  Trustees  shall  have the power to borrow  money or
otherwise  obtain  credit  and to secure  the same by  mortgaging,  pledging  or
otherwise subjecting as security the assets of the Fund, to endorse,  guarantee,
or undertake the  performance of any  obligation,  contract or engagement of any
other Person and to lend Fund assets.


                                      -6-
<PAGE>


            SECTION 3.6 DELEGATION;  COMMITTEES.  The Trustees shall have power,
consistent with their continuing  exclusive authority over the management of the
Fund and the  Fund  Property,  to  delegate  from  time to time to such of their
number or to officers,  employees or agents of the Fund the doing of such things
and the  execution  of such  instruments  either  in the name of the Fund or the
names of the Trustees or otherwise as the Trustees may deem expedient.

            SECTION 3.7 COLLECTION AND PAYMENT. The Trustees shall have power to
collect  all  property  due to the Fund;  to pay all  claims,  including  taxes,
against the Fund  Property;  to  prosecute,  defend,  compromise  or abandon any
claims  relating  to the Fund  Property;  to  foreclose  any  security  interest
securing any  obligations,  by virtue of which any property is owed to the Fund;
and to enter into releases, agreements and other instruments.

            SECTION 3.8 EXPENSES. The Trustees shall have the power to incur and
pay  any  expenses  which  in the  opinion  of the  Trustees  are  necessary  or
incidental  to carry  out any of the  purposes  of the  Declaration,  and to pay
reasonable  compensation  from the funds of the Fund to  themselves as Trustees.
The Trustees shall fix the compensation of all officers, employees and Trustees.

            SECTION 3.9 MANNER OF ACTING;  BY-LAWS. Except as otherwise provided
herein or in the By-Laws or by any  provisions of law, any action to be taken by
the Trustees may be taken by a majority of the Trustees  present at a meeting of
Trustees (a quorum  being  present),  including  any meeting  held by means of a
conference  telephone  circuit or similar  communications  equipment by means of
which all  persons  participating  in the  meeting  can hear each  other,  or by
written  consents  of all the  Trustees.  The  Trustees  may adopt  By-Laws  not
inconsistent with this Declaration to provide for the conduct of the business of
the Fund and may amend or repeal  such  By-Laws to the extent  such power is not
reserved to the Shareholders.

            SECTION 3.10 MISCELLANEOUS POWERS. The Trustees shall have the power
to: (a) employ or contract with such Persons as the Trustees may deem  desirable
for the  transaction of the business of the Fund; (b) enter into joint ventures,
partnerships and any other combinations or associations;  (c) remove Trustees or
fill  vacancies in or add to their  number,  elect and remove such  officers and
appoint and terminate such agents or employees as they consider appropriate, and
appoint from their own number,  and terminate,  any one or more committees which
may  exercise  some or all of the power and  authority  of the  Trustees  as the
Trustees  may  determine;  (d)  purchase,  and pay  for  out of  Fund  Property,
insurance  policies insuring the Shareholders,  Trustees,  officers,  employees,
agents,  investment  advisers,  distributors,  selected  dealers or  independent
contractors of the Fund against all claims arising by reason of holding any such
position  or by reason of any  action  taken or  omitted to be taken by any such
Person in such capacity,  whether or not constituting negligence,  or whether or
not the Fund  would  have the  power  to  indemnify  such  Person  against  such
liability;  (e) establish  pension,  profit-sharing,  share purchase,  and other
retirement,  incentive and benefit plans for any Trustees,  officers,  employees
and agents of the Fund; (f) to the extent permitted by law, indemnify any person


                                      -7-
<PAGE>


with whom the Fund has dealings, including any Investment Adviser,  Distributor,
Transfer  Agent and  selected  dealers,  to such  extent as the  Trustees  shall
determine;  (g) guarantee indebtedness or contractual obligations of others; (h)
determine  and change  the  fiscal  year of the Fund and the method by which its
accounts  shall be kept;  and (i) adopt a seal for the Fund,  but the absence of
such seal shall not impair the validity of any instrument  executed on behalf of
the Fund.

            SECTION  3.11  PRINCIPAL   TRANSACTIONS.   Except  in   transactions
permitted by the 1940 Act or any rule or regulation thereunder,  or any order of
exemption  issued by the Commission,  or effected to implement the provisions of
any agreement to which the Fund is a party, the Trustees shall not, on behalf of
the Fund,  buy any  securities  (other than Shares) from or sell any  securities
(other  than  Shares)  to, or lend any  assets of the Fund to,  any  Trustee  or
officer of the Fund or any firm of which any such Trustee or officer is a member
acting as  principal,  or have any such dealings  with any  Investment  Adviser,
Distributor or Transfer Agent or with any Affiliated Person of such Person;  but
the Fund or any Series thereof may employ any such Person, or firm or company in
which such Person is an Interested Person, as broker, legal counsel,  registrar,
transfer agent, dividend disbursing agent or custodian upon customary terms.

            SECTION 3.12 LITIGATION. The Trustees shall have the power to engage
in and to prosecute,  defend, compromise,  abandon, or adjust, by arbitration or
otherwise,  any  actions,  suits,  proceedings,  disputes,  claims,  and demands
relating to the Fund, and out of the assets of the Fund to pay or to satisfy any
debts, claims or expenses incurred in connection  therewith,  including those of
litigation,  and such power shall include  without  limitation  the power of the
Trustees or any appropriate  committee thereof,  in the exercise of their or its
good faith business judgment, to dismiss any action, suit, proceeding,  dispute,
claim, or demand,  derivative or otherwise,  brought by any person,  including a
Shareholder in its own name or the name of the Fund,  whether or not the Fund or
any of the  Trustees  may be named  individually  therein or the subject  matter
arises by reason of business for or on behalf of the Fund.

            SECTION 3.13  TRUSTEES AND OFFICERS AS  SHAREHOLDERS.  No officer or
Trustee of the Fund, and no officer or director of the Investment Adviser or the
Distributor,  and no Investment Adviser or Distributor of the Fund, shall take a
short position in the securities issued by the Fund.

                                   ARTICLE IV

                        INVESTMENT ADVISER, DISTRIBUTOR,
                          CUSTODIAN AND TRANSFER AGENT
                          ----------------------------

            SECTION 4.1  INVESTMENT  ADVISER.  Subject to approval by a Majority
Shareholder  Vote, the Trustees may in their  discretion from time to time enter
into one or more investment  advisory or management  contracts whereby the other
party or parties to any such contracts  shall undertake to furnish the Fund such
management, investment advisory, administration,  accounting, legal, statistical
and research facilities and services,  promotional or marketing activities,  and
such other  facilities and services,  if any, as the Trustees shall from time to
time consider  desirable and all upon such terms and  conditions as the Trustees
may in  their  discretion  determine.  Notwithstanding  any  provisions  of this
Declaration, the Trustees may authorize the Investment Advisers, or any of them,
under any such contracts  (subject to such general or specific  instructions  as
the Trustees may from time to time adopt) to effect purchases,  sales,  loans or


                                      -8-
<PAGE>


exchanges of portfolio securities and other investments of the Fund on behalf of
the Trustees or may  authorize  any officer,  employee or Trustee to effect such
purchases,  sales,  loans  or  exchanges  pursuant  to  recommendations  of such
Investment  Advisers,  or any of them  (and all  without  further  action by the
Trustees).  Any such  purchases,  sales,  loans and exchanges shall be deemed to
have been authorized by all of the Trustees.

            SECTION  4.2  ADMINISTRATIVE  SERVICES.  The  Trustees  may in their
discretion from time to time contract for administrative  personnel and services
whereby  the  other  party  shall  agree to  provide  the  Trustees  or the Fund
administrative  personnel  and  services to operate the Fund on a daily or other
basis,  on such terms and  conditions  as the Trustees  may in their  discretion
determine. Such services may be provided by one or more persons or entities.

            SECTION 4.3  DISTRIBUTOR.  The Trustees may in their discretion from
time to time enter into one or more contracts,  providing for the sale of Shares
whereby the Fund may either agree to sell the Shares to the other parties to the
contracts,  or any of them,  or appoint any such other party its sales agent for
such  Shares.  In either  case,  any such  contract  shall be on such  terms and
conditions as the Trustees may in their  discretion  determine not  inconsistent
with the  provisions  of this  Article  IV or the  By-Laws,  including,  without
limitation,  the provision  for the  repurchase or sale of shares of the Fund by
such  other  party as  principal  or as agent of the Fund,  and for entry by the
other parties to the contracts into selected  dealer  agreements with registered
securities dealers to further the purpose of distribution of the Shares.

            SECTION 4.4 TRANSFER  AGENT.  The  Trustees may in their  discretion
from time to time enter into a transfer agency and shareholder  service contract
whereby the other party to such  contract  shall  undertake to furnish  transfer
agency and shareholder  services to the Fund. The contract shall have such terms
and  conditions  as  the  Trustees  may  in  their   discretion   determine  not
inconsistent with the Declaration or the By-Laws.  Such services may be provided
by one or more persons.

            SECTION 4.5 CUSTODIAN.  The Trustees may appoint or otherwise engage
one or more banks or trust companies,  each having an aggregate capital, surplus
and undivided  profits (as shown in its last published  report) of at least five
million dollars  ($5,000,000) to serve as Custodian with authority as its agent,
but subject to such restrictions, limitations and other requirements, if any, as
may be contained in the By-Laws of the Fund.

            SECTION  4.6 PARTIES TO  CONTRACT.  Any  contract  of the  character
described in Sections 4.1, 4.2, 4.3, 4.4 or 4.5 of this Article IV and any other
contract  may be  entered  into  with any  Person,  although  one or more of the
Trustees  or  officers  of  the  Fund  may  be an  officer,  director,  trustee,
shareholder, or member of such other party to the contract, and no such contract
shall be invalidated or rendered voidable by reason of the existence of any such
relationship; nor shall any Person holding such relationship be liable merely by
reason of such  relationship  for any loss or  expense  to the Fund  under or by
reason of said  contract  or  accountable  for any profit  realized  directly or
indirectly  therefrom,  provided  that the  contract  when  entered into was not
inconsistent  with the provisions of this Article IV. The same Person may be the
other party to any  contracts  entered into  pursuant to Sections 4.1, 4.2, 4.3,
4.4 or 4.5 above or otherwise,  and any individual may be financially interested
or  otherwise  affiliated  with  Persons  who are  parties  to any or all of the
contracts mentioned in this Section 4.6.


                                      -9-
<PAGE>


                                    ARTICLE V

                    LIMITATIONS OF LIABILITY OF SHAREHODLERS,
                               TRUSTEES AND OTHERS
                               -------------------

            SECTION 5.1 NO PERSONAL LIABILITY OF SHAREHOLDERS, TRUSTEES, etc. No
Shareholder shall be subject to any personal liability  whatsoever to any Person
in  connection  with Fund  Property or the acts,  obligations  or affairs of the
Fund. The Trustees shall have no power to bind any Shareholder  personally or to
call upon any  Shareholder  for the  payment  of any sum of money or  assessment
whatsoever  other than such as the Shareholder may at any time personally  agree
to pay by way of subscription to any Shares or otherwise.  Shareholder liability
for the acts and obligations of the Fund is hereby expressly  disclaimed.  Every
note, bond, contract, or other undertaking issued by or on behalf of the Fund or
the Trustees relating to the Fund shall include a notice and provision  limiting
the obligation  represented thereby to the Fund and its assets (but the omission
of such  notice and  provision  shall not  operate to impose  any  liability  or
obligation on any Shareholder).  No Trustee,  officer,  employee or agent of the
Fund shall be subject to any personal liability  whatsoever to any Person, other
than the Fund or its  Shareholders,  in  connection  with Fund  Property  or the
affairs of the Fund, save only that arising from bad faith, willful misfeasance,
gross negligence or reckless  disregard for his or her duty to such Person;  and
all such  Persons  shall look solely to the Fund  Property for  satisfaction  of
claims of any nature arising in connection  with the affairs of the Fund. If any
Shareholder, Trustee, officer, employee or agent, as such, of the Fund is made a
party to any suit or proceeding to enforce any such  liability,  he or she shall
not,  on account  thereof,  be held to any  personal  liability.  The Fund shall
indemnify  and hold each  Shareholder  harmless  from and against all claims and
liabilities,  to which such  Shareholder  may become subject by reason of his or
her being or having been a  Shareholder,  other than by reason of his or her own
wrongful act or omission, and shall reimburse such Shareholder for all legal and
other  expenses  reasonably  incurred by him or her in connection  with any such
claim or liability.  The rights accruing to a Shareholder under this Section 5.1
shall not  exclude  any other  right to which such  Shareholder  may be lawfully
entitled,  nor shall anything herein contained restrict the right of the Fund to
indemnify or reimburse a Shareholder  in any  appropriate  situation even though
not specifically provided herein.

            SECTION 5.2  NON-LIABILITY  OF TRUSTEES,  ETC. No Trustee,  officer,
employee or agent of the Fund shall be liable to the Fund, its Shareholders,  or
to any Shareholder, Trustee, officer, employee, or agent thereof, for any action
or failure to act (including without limitation the failure to compel in any way
any former or acting  Trustee to redress any breach of trust) except for his own
bad faith, willful misfeasance, gross negligence or reckless disregard of his or
her duties.

            SECTION 5.3  INDEMNIFICATION
            ----------------------------

            (a) The Trustees  shall provide for  indemnification  by the Fund or
any person who is, or has been,  a Trustee,  officer,  employee  or agent of the
Fund against all liability and against all expenses  reasonably incurred or paid
by him in connection with any claim,  action,  suit or proceeding in which he or
she becomes  involved as a party or  otherwise  by virtue of his or her being of


                                      -10-
<PAGE>


having been a Trustee,  officer,  employee or agent and against  amounts paid or
incurred by him or her in the settlement thereof, in such manner as the Trustees
may provide form time to time in the By-Laws.

            (b) The words "claim,"  "action," "suit" or "proceeding" shall apply
to all  claims,  actions,  suits  or  proceedings  (civil,  criminal  or  other,
including  appeals),  actual  or  threatened;  and  the  words  "liability"  and
"expenses" shall include, without limitation, attorneys' fees, costs, judgments,
amounts paid in settlement, fines, penalties and other liabilities.

            SECTION  5.4 NO BOND  REQUIRED  OF  TRUSTEES.  No  Trustee  shall be
obligated to give any bond or other  security for the  performance of any of his
or her duties hereunder.

            SECTION 5.5 NO DUTY OF  INVESTIGATION;  NOTICE IN FUND  INSTRUMENTS,
ETC. No  purchaser,  lender,  transfer  agent or other  Person  dealing with the
Trustees  or any  officer,  employee or agent of the Fund shall be bound to make
any inquiry concerning the validity of any transaction  purporting to be made by
the  Trustees  or by said  officer,  employee  or  agent  or be  liable  for the
application of money or property paid,  loaned,  or delivered to or on the order
of the  Trustees  or of said  officer,  employee  or  agent.  Every  obligation,
contract,  instrument,  certificate,  Share,  other  security  of  the  Fund  or
undertaking, and every other act or thing whatsoever executed in connection with
the Fund shall be  conclusively  presumed  to have been  executed or done by the
executors thereof only in their capacity as officers, employees or agents of the
Fund. Every written obligation, contract, instrument,  certificate, Share, other
security of the Fund or undertaking  made or issued by the Trustees shall recite
that the same is  executed  or made by them not  individually,  but as  Trustees
under  the  Declaration,  and that the  obligations  of the Fund  under any such
instrument   are  not  binding  upon  any  of  the  Trustees  or   Shareholders,
individually,  but bind only the Fund, and may contain any further recital which
they, or any one of them, may deem appropriate, but the omission of such recital
shall  not  affect  the  validity  of  such  obligation,   contract  instrument,
certificate,  share,  security or undertaking  and shall not operate to bind the
Trustees or Shareholders  individually.  The Trustees may maintain insurance for
the  protection of the Fund  Property,  its  Shareholders,  Trustees,  officers,
employees and agents in such amount as the Trustees shall deem adequate to cover
possible tort liability,  and such other insurance as the Trustees in their sole
judgment shall deem advisable.

            SECTION 5.6  RELIANCE ON EXPERTS,  ETC.  Each Trustee and officer or
employee of the Fund shall,  in the  performance of his or her duties,  be fully
and completely  justified and protected with regard to any act or any failure to
act  resulting  from  reliance  in good faith upon the books of account or other
records of the Fund,  upon an opinion of counsel,  or upon  reports  made to the
Fund  by  any  of its  officers  or  employees  or by  any  Investment  Adviser,
Distributor, Transfer Agent, selected dealers, accountants,  appraisers or other
experts or consultants  selected with reasonable care by the Trustees,  officers
or employees of the Fund,  regardless of whether such counsel or expert may also
be a Trustee.


                                      -11-
<PAGE>


                                   ARTICLE VI

                          SHARES OF BENEFICIAL INTEREST
                          -----------------------------

            SECTION 6.1 BENEFICIAL  INTEREST.  The interest of the beneficiaries
hereunder shall be divided into  transferable  shares of beneficial  interest of
$.01 par value.  The number of such  shares of  beneficial  interest  authorized
hereunder is unlimited. All Shares issued hereunder,  including Shares issued in
connection  with a dividend in Shares or a split in Shares,  shall be fully paid
and nonassessable.

            SECTION  6.2  RIGHTS  OF  SHAREHOLDERS.  The  ownership  of the Fund
Property of every description and the right to conduct any business hereinbefore
described are vested  exclusively in the Trustees,  and the  Shareholders  shall
have no interest therein other than the beneficial  interest  conferred by their
Shares,  and they shall have no right to call for any  partition  or division of
any  property,  profits,  rights or interests of the Fund nor can they be called
upon to assume  any  losses of the Fund or suffer an  assessment  of any kind by
virtue of their  ownership  of Shares.  The Shares  shall be  personal  property
giving only the rights in the  Declaration  specifically  set forth.  The Shares
shall not entitle the holder to preference, preemptive, appraisal, conversion or
exchange rights.

            SECTION  6.3 TRUST  ONLY.  It is the  intention  of the  Trustees to
create only the relationship of Trustee and beneficiary between the Trustees and
each  Shareholder  from time to time. It is not the intention of the Trustees to
create a general  partnership,  limited  partnership,  joint stock  association,
corporation,  bailment  or any other  form of legal  relationship  other  than a
trust.  Nothing in the Declaration  shall be construed to make the Shareholders,
either by themselves or with the Trustees,  partners or members of a joint stock
association.

            SECTION 6.4  ISSUANCE OF SHARES.  The  Trustees in their  discretion
may,  from time to time  without  vote of the  Shareholders,  issue  Shares,  in
addition  to the then  issued and  outstanding  Shares  and  Shares  held in the
treasury,   to  such  party  or  parties   and  for  such  amount  and  type  of
consideration,  including  cash or  property,  at such time or times and on such
terms as the Trustees may deem best, and may in such manner acquire other assets
(including the  acquisition  of assets  subject to, and in connection  with, the
assumption of liabilities)  and  businesses.  In connection with any issuance of
Shares,  the  Trustees  may  issue  fractional  Shares  and  Shares  held in the
treasury. The Trustees may from time to time divide or combine the Shares into a
greater or lesser number without thereby changing the  proportionate  beneficial
interests in the Fund without the vote of the Shareholders. Contributions to the
Fund may be accepted for whole Shares  and/or  1/1,000ths of a Share or integral
multiples thereof.

            SECTION 6.5 REGISTER OF SHARES.  A register shall be kept in respect
of the Fund at the principal  office of the Fund or at an office of the Transfer
Agent which shall  contain the names and addresses of the  Shareholders  and the
number  of  Shares  held by them  respectively  and a  record  of all  transfers
thereof. Such register may be in written form or any other form capable of being
converted into written form within a reasonable time for visual inspection. Such
register  shall be  conclusive  as to who are the  holders of the Shares and who


                                      -12-
<PAGE>


shall be entitled to receive dividends or distributions or otherwise to exercise
or enjoy the rights of Shareholders. No Shareholder shall be entitled to receive
payment of any dividend or distribution,  nor to have notice given to him or her
as  herein  or in the  By-Laws  provided,  until he or she has  given his or her
address to the Transfer  Agent or such other officer or agent of the Trustees as
shall  keep  the  said  register  for  entry  thereon.  The  Trustees,  in their
discretion,  may authorize  the issuance of Share  certificates  and  promulgate
appropriate rules and regulations as to their use.

            SECTION 6.6 TRANSFER OF SHARES.  Shares shall be transferable on the
records  of the Fund only by the  record  holder  thereof or by his or her agent
thereunto  duly  authorized  in writing,  upon  delivery to the  Trustees or the
Transfer  Agent of a duly executed  instrument  of transfer,  together with such
evidence of the  genuineness  of each such  execution and  authorization  and of
other  matters as may  reasonably  be required.  Upon such delivery the transfer
shall be recorded on the register of the Trust.  Until such record is made,  the
Shareholder  of record  shall be deemed to be the holder of such  Shares for all
purposes  hereunder and neither the Trustees nor any Transfer Agent or registrar
nor any  officer,  employee or agent of the Fund shall be affected by any notice
of the proposed transfer.

            Any person  becoming  entitled to any Shares in  consequence  of the
death, bankruptcy, or incompetence of any Shareholder, or otherwise by operation
of law, shall be recorded on the register of Shares as the holder of such Shares
upon production of the proper  evidence  thereof to the Trustees or the Transfer
Agent,  but until such record is made, the Shareholder of record shall be deemed
to be the holder of such  Shares for all  purposes  hereunder  and  neither  the
Trustees  nor any Transfer  Agent or  registrar  nor any officer or agent of the
Fund shall be affected by any notice of such death,  bankruptcy or incompetence,
or other  operation of law,  except as may  otherwise be provided by the laws of
the Commonwealth of Massachusetts.

            SECTION 6.7 NOTICES.  Any and all notices to which any  Shareholders
may be entitled  and any and all  communications  shall be deemed duly served or
given if mailed, postage prepaid,  addressed to any Shareholder of record at his
or her last known  address  as  recorded  on the  register  of the Fund.  Annual
reports and proxy statements need not be sent to a Shareholder if: (i) an annual
report and proxy statement for two consecutive annual meetings, or (ii) all, and
at least two,  checks (if sent by first class mail) in payment of  dividends  or
interest  and  Shares  during a  twelve-month  period  have been  mailed to such
Shareholder's address and have been returned undelivered.  However,  delivery of
such  annual  reports and proxy  statements  shall  resume once a  Shareholder's
current address is determined.

            SECTION 6.8 VOTING POWERS. The Shareholders shall have power to vote
only (i) for the  election of  Trustees as provided in Section 2.2 hereof,  (ii)
for the removal of  Trustees  as  provided  in Section  2.2  hereof,  (iii) with
respect to any investment advisory or management contract as provided in Section
4.1,  (iv) with respect to  termination  of the Fund as provided in Section 8.2,
(v) with  respect  to any  amendment  of the  Declaration  to the  extent and as
provided  in  Section  8.3,  (vi) with  respect  to any  merger,  consolidation,
conversion  or sale of assets as provided in Sections  8.4,  8.5 and 8.6,  (vii)
with respect to incorporation or reorganization of the Fund to the extent and as
provided  in Section  8.5,  (viii) to the same extent as the  stockholders  of a
Massachusetts  business  corporation  as  to  whether  or  not a  court  action,


                                      -13-
<PAGE>


proceeding or claim should or should not be brought or  maintained  derivatively
or as a class  action on behalf  of the Fund or the  Shareholders  and (ix) with
respect to such  additional  matters  relating to the Fund as may be required by
law,  the  Declaration,  the  By-Laws or any  registration  of the Fund with the
Commission (or any successor  agency) or any state,  or as and when the Trustees
may consider  necessary or desirable.  Each whole Share shall be entitled to one
vote as to any matter on which it is entitled to vote and each fractional  Share
shall be entitled to a proportionate fractional vote, except that Shares held in
the treasury of the Fund as of the record date, as determined in accordance with
the  By-Laws,  shall not be voted.  There shall be no  cumulative  voting in the
election of Trustees.  Shareholders  shall have no  preemptive or other right to
subscribe to any additional Shares or other securities issued by the Fund. Until
Shares are issued,  the Trustees may exercise all rights of Shareholders and may
take any action  required by law, the  Declaration or the By-Laws to be taken by
Shareholders. The By-Laws may include further provisions for Shareholders' votes
and meetings and related matters.

                                   ARTICLE VII

                        DETERMINATION OF NET ASSET VALUE,
                          NET INCOME AND DISTRIBUTIONS
                          ----------------------------

            SECTION 7.1 NET ASSET VALUE. The net asset value of each outstanding
Share of the Fund shall be  determined on such days and at such time or times as
the Trustees may determine. The method of determination of net asset value shall
be  determined  by the  Trustees  and shall be as set forth in the  Registration
Statement.  The power and duty to make the  calculations may be delegated by the
Trustees to any Investment  Adviser,  the Custodian,  the Transfer Agent or such
other  person as the  Trustees by  resolution  may  determine.  The Trustees may
suspend the determination of net asset value to the extent permitted by the 1940
Act.

            SECTION 7.2  DISTRIBUTIONS TO SHAREHOLDERS.  The Trustees shall from
time  to time  distribute  ratably  among  the  Shareholders  of the  Fund  such
proportion of the net income, earnings,  profits, gains, surplus (including paid
in  surplus),  capital,  or assets of the Fund held by the  Trustees as they may
deem proper.  Such  distribution  may be made in cash or in property  (including
without  limitation any type of obligations of the Fund or any assets  thereof),
and the Trustees  may  distribute  ratably  among the  Shareholders  of the Fund
additional  Shares  issuable  hereunder in such manner,  at such times,  on such
terms as the  Trustees  may deem  proper.  Such  distributions  may be among the
Shareholders  of  record   (determined  in  accordance  with  the   Registration
Statement) of the Fund at the time of declaring a  distribution  or may be among
the  Shareholders of record of the Fund at such later date as the Trustees shall
determine. The Trustees may always retain from the net income, earnings, profits
or gains of the Fund such amount as they may deem  necessary to pay the debts or
expenses  of the Fund or to meet  obligations  of the Fund,  or as they may deem
desirable  to  use  in the  conduct  of its  affairs  or to  retain  for  future
requirements or extensions of the business.  The Trustees may adopt and offer to
Shareholders of the Fund such dividend  reinvestment  plans as the Trustees deem
appropriate.

            Inasmuch  as the  computation  of net income  and gains for  federal
income tax  purposes  may vary from the  computation  thereof on the books,  the
above  provisions  shall be  interpreted to give the Trustees the power in their
discretion  to  distribute  for any fiscal  year as  ordinary  dividends  and as
capital gains  distributions,  respectively,  additional  amounts  sufficient to
enable the Fund to avoid or reduce liability for taxes.


                                      -14-
<PAGE>


            SECTION 7.3 DETERMINATION OF NET INCOME. The Trustees shall have the
power  to  determine  the  net  income  of the  Fund  and  from  time to time to
distribute  such net income ratably among the  Shareholders as dividends in cash
or additional Shares issuable hereunder. The determination of net income and the
resultant  declaration  of dividends  shall be as set forth in the  Registration
Statement.  The  Trustees  or their  delegates  shall  have full  discretion  to
determine  whether any cash or property received by the Fund shall be treated as
income or as principal  and whether any item of expense  shall be charged to the
income or the  principal  account,  and their  determination  made in good faith
shall be  conclusive  upon  the  Shareholders.  In the  case of stock  dividends
received, the Trustees shall have full discretion to determine,  in the light of
the  particular  circumstances,  how much, if any, of the value thereof shall be
treated as income, the balance, if any, to be treated as principal.

            SECTION 7.4 POWER TO MODIFY  FOREGOING  PROCEDURES.  Notwithstanding
any of the foregoing provisions of this Article VII, the Trustees may prescribe,
in their absolute discretion, such other bases and times for determining the per
Share net  asset  value of the  Shares or net  income,  or the  declaration  and
payment of dividends and distributions,  as they may deem necessary or desirable
to enable the Fund to comply with any  provision of the 1940 Act, or any rule or
regulation thereunder,  or any order of exemption issued by the Commission,  all
as in effect now or hereafter amended or modified.

                                  ARTICLE VIII

                            DURATION; TERMINATION OF
                         FUND; AMENDMENT; MERGERS, ETC.
                         ------------------------------

            SECTION 8.1 DURATION.  The Fund shall continue without limitation of
time but subject to the provisions of this Article VIII.

            SECTION 8.2  TERMINATION OF FUND.
            ---------------------------------

            (a) The Fund may be terminated  (i) by the  affirmative  vote of the
holders of not less than  two-thirds  (66-2/3%)  of the Shares  outstanding  and
entitled  to vote at any  meeting  of  Shareholders  of the Fund  except  that a
Majority  Shareholder  Vote shall be sufficient if  termination  of the Fund has
been  recommended  by two-thirds  of the  Trustees,  or (ii) by an instrument in
writing,  without a meeting,  signed by a majority of the Trustees and consented
to by the holders of not less than two-thirds of such Shares of the Trust.  Upon
the termination of the Fund:

                  (i) The Fund shall carry on no business except for the purpose
of winding up its affairs.

                  (ii) The Trustees  shall proceed to wind up the affairs of the
Fund and all of the powers of the Trustees under this Declaration shall continue
until the affairs of the Fund shall have been wound up,  including  the power to
fulfill or  discharge  the  contracts  of the Fund,  collect its  assets,  sell,
convey,  assign,  exchange,  transfer or otherwise dispose of all or any part of


                                      -15-
<PAGE>


the remaining Fund Property to one or more persons at public or private sale for
consideration which may consist in whole or in part of cash, securities or other
property of any kind, discharge or pay its liabilities, and to do all other acts
appropriate  to liquidate  its  business;  provided  that any sale,  conveyance,
assignment,  exchange, transfer or other disposition of all or substantially all
the Fund Property shall require Shareholder  approval in accordance with Section
8.4 hereof.

                  (iii) After paying or adequately  providing for the payment of
all  liabilities,  and upon receipt of such releases,  indemnities and refunding
agreements,  as they deem  necessary  for their  protection,  the  Trustees  may
distribute the remaining Fund Property, in cash or in kind or partly each, among
the Shareholders of the Fund according to their respective rights.

            (b)  After   termination  of  the  Fund  and   distribution  to  the
Shareholders  as herein  provided,  a majority of the Trustees shall execute and
lodge among the records of the Fund an instrument  in writing  setting forth the
fact of such  termination,  and the Trustees shall  thereupon be discharged from
all further  liabilities and duties with respect to the Fund, and the rights and
interests of all Shareholders of the Fund shall thereupon cease.

            SECTION 8.3  AMENDMENT PROCEDURES.
            ---------------------------------

            (a) Except as provided in paragraph  (c) of this  Section 8.3,  this
Declaration  may be  amended  by a Majority  Shareholder  Vote,  at a meeting of
Shareholders,  or by written  consent  without a meeting.  The Trustees may also
amend this Declaration without the vote or consent of Shareholders (i) to change
the  name of the  Fund,  (ii) to  supply  any  omission,  or  cure,  correct  or
supplement any ambiguous,  defective or inconsistent  provision hereof, (iii) if
they deem it  necessary  to conform  this  Declaration  to the  requirements  of
applicable  federal  or state laws or  regulations  or the  requirements  of the
Internal  Revenue  Code,  or to eliminate or reduce any federal,  state or local
taxes  which  are or may be  payable  by the Fund or the  Shareholders,  but the
Trustees shall not be liable for failing to do so, or (iv) for any other purpose
which does not adversely  affect the rights of any  Shareholder  with respect to
which the amendment is or purports to be applicable.

            (b) No  amendment  may be made under this  Section  8.3 which  would
change any rights with  respect to any Shares of the Fund by reducing the amount
payable  thereon upon  liquidation  of the Fund or by diminishing or eliminating
any voting  rights  pertaining  thereto,  except with the vote or consent of the
holders of  two-thirds  of the Shares of the Fund  outstanding  and  entitled to
vote.  Nothing  contained in this Declaration shall permit the amendment of this
Declaration to impair the exemption from personal liability of the Shareholders,
Trustees,  officers,  employees and agents of the Fund or to permit  assessments
upon Shareholders set forth in Section 5.1 above.

            (c) No  amendment  may be made under this  Section  8.3 which  shall
amend,  alter,  change or repeal any of the provisions of Sections 8.3, 8.4, 8.6
and 8.7 unless the amendment  effecting such  amendment,  alteration,  change or
repeal shall receive the  affirmative  vote or consent of that proportion of the
Shares  outstanding  and  entitled to vote as would be  necessary to approve the
transaction or action set forth in that respective  section under  circumstances
where the Board of Trustees has not  recommended  approval of the transaction or


                                      -16-
<PAGE>


action.  Such  affirmative  vote or consent  shall be in addition to the vote or
consent of the  holders of Shares  otherwise  required by law or by the terms of
any class or series of preferred stock, whether now or hereafter authorized,  or
any agreement between the Fund and any national securities exchange.

            (d) A  certificate  signed  by a  majority  of the  Trustees  or the
Secretary or any Assistant Secretary of the Fund, setting forth an amendment and
reciting  that it was duly  adopted by the  Shareholders  or by the  Trustees as
aforesaid or a copy of the Declaration,  as amended,  and executed by a majority
of the Trustees or certified by the Secretary or any Assistant  Secretary of the
Trust,  shall be  conclusive  evidence of such  amendment  when lodged among the
records of the Fund.  Unless such amendment or such  certificate sets forth some
later time for the  effectiveness  of such  amendment,  such amendment  shall be
effective when lodged among the records of the Fund.

            Notwithstanding  any other provision hereof,  until such time as the
Registration  Statement  covering the first public offering of securities of the
Fund shall have become effective,  this Declaration may be terminated or amended
in any respect by the  affirmative  vote of a majority of the  Trustees or by an
instrument signed by a majority of the Trustees.

            SECTION 8.4 MERGER,  CONSOLIDATION AND SALE OF ASSETS.  The Fund may
merge or consolidate  with any other other  corporation,  association,  trust or
other  organization or may sell, lease or exchange all or  substantially  all of
the Fund Property,  including its good will,  upon such terms and conditions and
for such  consideration  when and as authorized,  at any meeting of Shareholders
called for the purpose,  by the affirmative vote of the holders of not less than
two-thirds (66-2/3%) of the Shares of the Fund outstanding and entitled to vote,
or by an instrument or instruments in writing without a meeting, consented to by
the holders of not less than  two-thirds  (66-2/3%)  of such  Shares;  provided,
however,  that,  if such  merger,  consolidation,  sale,  lease or  exchange  is
recommended by two-thirds of the Trustees,  a Majority Shareholder Vote shall be
sufficient  authorization;  and any such merger,  consolidation,  sale, lease or
exchange  shall be deemed for all purposes to have been  accomplished  under and
pursuant to the laws of the  Commonwealth of  Massachusetts.  Nothing  contained
herein shall be construed as requiring  approval of shareholders for any sale of
assets in the ordinary course of business of the Fund.

            SECTION 8.5  INCORPORATION  AND  REORGANIZATION.  With approval of a
Majority  Shareholder  Vote, the Trustees may cause to be organized or assist in
organizing a corporation or corporations  under the laws of any  jurisdiction or
any other trust, partnership, association or other organization to take over all
of the Fund  Property  or to  carry on any  business  in  which  the Fund  shall
directly or indirectly have any interest,  and to sell,  convey and transfer the
Fund  Property  to any such  corporation,  trust,  partnership,  association  or
organization in exchange for the shares or securities thereof or otherwise,  and
to lend money to,  subscribe for the shares or securities of, and enter into any
contracts  with  any  such  corporation,  trust,  partnership,   association  or
organization  in which the Fund holds or is about to acquire shares or any other
interest. Subject to Section 8.4 hereof, the Trustees may also cause a merger or
consolidation   between  the  Fund  or  any  successor   thereto  and  any  such


                                      -17-
<PAGE>


corporation, trust, partnership, association or other organization if and to the
extent  permitted  by law,  as  provided  under the law then in effect.  Nothing
contained  herein shall be construed as requiring  approval of Shareholders  for
the  Trustees  to  organize or assist in  organizing  one or more  corporations,
trusts, partnerships, associations or other organizations and selling, conveying
or  transferring  a  portion  of the  Fund  Property  to such  organizations  or
entities.

            SECTION 8.6 CONVERSION. The Fund may be converted at any time from a
"closed-end  company" to an "open-end company" as those terms are defined by the
1940 Act,  upon the  approval of such a proposal,  together  with the  necessary
amendments  to the  Declaration  of Trust to permit  such a  conversion,  by the
holders of not less than two-thirds  (66-2/3%) of the Fund's  outstanding Shares
entitled to vote,  except that if such proposal is  recommended by two-thirds of
the total number of Trustees  then in office,  such proposal may be adopted by a
Majority  Shareholder  Vote.  From  time  to time  the  Trustees  will  consider
recommending  to  the  Shareholders  a  proposal  to  convert  the  Fund  from a
"closed-end  company" to an  "open-end  company."  Upon the  recommendation  and
subsequent  adoption of such a proposal  and the  necessary  amendments  to this
Declaration to permit such a conversion by not less than two-thirds (66-2/3%) of
the Fund's  outstanding  Shares entitled to vote, the Fund shall, upon complying
with any  requirements  of the 1940 Act and  state  law,  become  an  "open-end"
investment company. Such affirmative vote or consent shall be in addition to the
vote or consent of the holders of the Shares  otherwise  required by law, or any
agreement between the Fund and any national securities exchange.

            SECTION 8.7  CERTAIN TRANSACTIONS.
            ---------------------------------

            (a)  Notwithstanding  any other  provision of this  Declaration  and
subject to the exceptions  provided in paragraph (d) of this Section,  the types
of  transactions  described in paragraph  (c) of this Section  shall require the
affirmative vote or consent of the holders of eighty percent (80%) of the Shares
outstanding  and entitled to vote,  when a Principal  Shareholder (as defined in
paragraph (b) of this Section) is a party to the  transaction.  Such affirmative
vote or consent  shall be in  addition  to the vote or consent of the holders of
Shares  otherwise  required  by law or by the  terms of any  class or  series of
preferred stock, whether now or hereafter  authorized,  or any agreement between
the Fund and any national securities exchange.

            (b) The term  "Principal  Shareholder"  shall mean any  corporation,
person or other entity which is the beneficial owner, directly or indirectly, of
more than five  percent  (5%) of the  outstanding  Shares and shall  include any
affiliate  or  associate,  as such terms are defined in clause (ii) below,  of a
Principal  Shareholder.  For the  purposes of this  Section,  in addition to the
Shares which a corporation,  person or other entity  beneficially owns directly,
(a) any corporation, person or other entity shall be deemed to be the beneficial
owner of any  Shares  (i)  which it has the  right to  acquire  pursuant  to any
agreement or upon exercise of conversion  rights or warrants,  or otherwise (but
excluding  share  options  granted by the Fund) or (ii)  which are  beneficially
owned, directly or indirectly (including Shares deemed owned through application
of clause (i) above), by any other corporation,  person or entity with which its
"affiliate" or "associate" (as defined below) has any agreement,  arrangement or
understanding  for the purpose of  acquiring,  holding,  voting or  disposing of
Shares, or which is its "affiliate" or "associate" as those terms are defined in
Rule 12b-2 of the General Rules and  Regulations  under the Securities  Exchange
Act of 1934,  and (b) the  outstanding  Shares shall include Shares deemed owned
through  application  of clauses  (i) and (ii) above but shall not  include  any
other Shares which may be issuable  pursuant to any agreement,  or upon exercise
of conversion rights or warrants, or otherwise.


                                      -18-
<PAGE>


            (c) This Section shall apply to the following transactions:

                  (i) The merger or  consolidation of the Fund or any subsidiary
of the Fund with or into any Principal Shareholder.

                  (ii)  The  issuance  of  any  securities  of the  Fund  to any
Principal Shareholder for cash.

                  (iii) The sale,  lease or exchange  of all or any  substantial
part of the  assets  of the Fund to any  Principal  Shareholder  (except  assets
having an aggregate fair market value of less than  $1,000,000,  aggregating for
the purpose of such  computation  all assets  sold,  leased or  exchanged in any
series of similar transactions within a twelve-month period).

                  (iv) The sale, lease or exchange to the Fund or any subsidiary
thereof,  in exchange for  securities of the Fund of any assets of any Principal
Shareholder  (except  assets having an aggregate  fair market value of less than
$1,000,000,  aggregating  for the purposes of such  computation all assets sold,
leased or exchanged in any series of similar  transactions within a twelve-month
period).

                  (v) The liquidation or dissolution of the Fund.

                  (vi) A change  in the  nature of the  business  of the Fund so
that it would cease to be an investment company registered under the 1940 Act.

                  (vii) The conversion of the Fund to an "open-end  company," or
any  amendment to the  Declaration  of Trust of the Fund that makes the Shares a
"redeemable security," as such terms are defined in the 1940 Act.

            (d) The  provisions  of this Section  shall not be applicable to (i)
any of the transactions described in paragraph (c) of this Section if two-thirds
of the  Board of  Trustees  of the Fund  shall by  resolution  have  approved  a
memorandum of understanding with such Principal  Shareholder with respect to and
substantially  consistent with such  transaction,  or (ii) any such  transaction
with any  corporation  of which a  majority  of the  outstanding  shares  of all
classes of stock normally entitled to vote in elections of directors is owned of
record or beneficially by the Fund and its subsidiaries.

            (e) The Board of Trustees shall have the power and duty to determine
for the purposes of this Section on the basis of  information  known to the Fund
whether (i) a  corporation,  person or entity  beneficially  owns more than five
percent (5%) of the outstanding Shares, (ii) a corporation,  person or entity is
an "affiliate" or  "associate"  (as defined above) of another,  (iii) the assets
being acquired or leased to or by the Fund or any subsidiary  thereof constitute
a substantial  part of the assets of the Fund and have an aggregate  fair market
value of less than $1,000,000 and (iv) the memorandum of understanding  referred
to in paragraph  (d) hereof is  substantially  consistent  with the  transaction
covered thereby.  Any such determination shall be conclusive and binding for all
purposes of this Section.


                                      -19-
<PAGE>


                                   ARTICLE IX

                             REPORTS TO SHAREHOLDERS
                             -----------------------

            The  Trustees  shall  at least  semi-annually  submit  or cause  the
officers of the Fund to submit to the Shareholders a written financial report of
the Fund,  including  financial  statements  which  shall at least  annually  be
certified by independent public accountants.

                                    ARTICLE X

                                  MISCELLANEOUS
                                  -------------

            SECTION 10.1 FILING. This Declaration and any amendment hereto shall
be filed in the office of the Secretary of the Commonwealth of Massachusetts and
in such other places as may be required under the laws of Massachusetts  and may
also be filed or recorded in such other places as the Trustees deem appropriate.
Each  amendment  so filed  shall be  accompanied  by a  certificate  signed  and
acknowledged by a Trustee or by the Secretary or any Assistant  Secretary of the
Fund  stating  that such action was duly taken in a manner  provided  herein.  A
restated Declaration, integrating into a single instrument all of the provisions
of the Declaration which are then in effect and operative,  may be executed from
time to time by a majority  of the  Trustees  and shall,  upon  filing  with the
Secretary of the Commonwealth of  Massachusetts,  be conclusive  evidence of all
amendments  contained  therein and may  thereafter be referred to in lieu of the
original Declaration and the various amendments thereto.

            SECTION 10.2 RESIDENT  AGENT.  Until  changed by the  Trustees,  the
principal office of the Fund shall be 7800 East Union Avenue, Suite 800, Denver,
Colorado 80237. Until changed by the Trustees, Lane & Altman, attention:  Joseph
F. Mazzella,  Esq., 101 Federal Street,  Boston, MA 02110, is the resident agent
of the Fund in the Commonwealth of Massachusetts.

            SECTION 10.3  GOVERNING LAW. By the execution  hereof,  the Trustees
agree that this  Declaration  shall be  effective  when  executed  by all of the
Trustees and delivered for filing to the Secretary of State of the  Commonwealth
of  Massachusetts  with  reference  to the laws  thereof  and the  rights of all
parties and the validity and  construction  of every  provision  hereof shall be
subject to and construed according to the laws of said State.

            SECTION 10.4 ORGANIZATIONAL  EXPENSES.  In the event that any person
advances the organizational  expenses of the Fund, such advances shall become an
obligation of the Fund, subject to such terms and conditions as may be fixed by,
and on a date  fixed by, or  determined  with  criteria  fixed by,  the Board of
Trustees, to be amortized over a period or periods to be fixed by the Board.

            SECTION 10.5  COUNTERPARTS.  The Declaration  may be  simultaneously
executed  in  several  counterparts,  each of  which  shall be  deemed  to be an
original,  and such  counterparts,  together,  shall constitute one and the same
instrument,   which  shall  be  sufficiently  evidenced  by  any  such  original
counterpart.


                                      -20-
<PAGE>


            SECTION 10.6 RELIANCE BY THIRD PARTIES.  Any certificate executed by
an individual who, according to the records of the Fund, appears to be a Trustee
hereunder,  or Secretary or Assistant Secretary of the Fund,  certifying to: (a)
the number or identity of Trustees or Shareholders, (b) the due authorization of
the execution of any instrument or writing, (c) the form of any vote passed at a
meeting of Trustees or Shareholders, (d) the fact that the number of Trustees or
Shareholders  present  at  any  meeting  or  executing  any  written  instrument
satisfies  the  requirements  of this  Declaration,  (e) the form of any By-Laws
adopted by or the identity of any officers  elected by the Trustees,  or (f) the
existence of any fact or facts which in any manner  relate to the affairs of the
Fund shall be conclusive evidence as to the matters so certified in favor of any
person dealing with the Trustees and their successors.

            SECTION 10.7  PROVISIONS IN CONFLICT WITH LAW OR REGULATIONS.
            ------------------------------------------------------------

            (a) The  provisions of the  Declaration  are  severable,  and if the
Trustees  shall  determine,  with  the  advice  of  counsel,  that  any of  such
provisions is in conflict with the 1940 Act, the  regulated  investment  company
provisions  of the  Internal  Revenue  Code or with  other  applicable  laws and
regulations,  the conflicting  provisions shall be deemed superseded by such law
or  regulation to the extent  necessary to eliminate  such  conflict;  provided,
however,  that  such  determination  shall  not  affect  any  of  the  remaining
provisions of the  Declaration or render invalid or improper any action taken or
omitted prior to such determination.

            (b) If any  provision  of the  Declaration  shall be held invalid or
unenforceable in any  jurisdiction,  such invalidity or  unenforceability  shall
pertain only to such provision in such  jurisdiction and shall not in any manner
affect such provision in any other  jurisdiction  or any other  provision of the
Declaration in any jurisdiction.


                                      -21-
<PAGE>


            IN WITNESS WHEREOF, the undersigned,  the Trustees of the Fund, have
executed this instrument this 15 day of November, 1991.



                                    /s/ John Kaweske
                                    ------------------------
                                    John Kaweske, as Trustee
                                      and not Individually
                                    7800 East Union Avenue
                                    Suite 800
                                    Denver, CO 80237



                                    /s/ R. Dalton Sim
                                    -------------------------
                                    R. Dalton Sim, as Trustee
                                      and not Individually
                                    7800 East Union Avenue
                                    Suite 800
                                    Denver, CO 80237



                                    /s/ Dan J. Hesser
                                    -------------------------
                                    Dan J. Hesser, as Trustee
                                      and not Individually
                                    7800 East Union Avenue
                                    Suite 800
                                    Denver, CO 80237


STATE OF COLORADO )
                  )  ss.:
COUNTY OF DENVER  )


            On this 15 day of  November,  1991,  John  Kaweske,  known to me and
known  to be the  individual(s)  described  in and who  executed  the  foregoing
instrument,  personally  appeared before me and they severally  acknowledged the
foregoing instrument to be their free act and deed.



/s/ Cheryl K. Howlett
- ---------------------
    Cheryl K. Howlett
    Notary Public

My Commission Expires February 22, 1995.


<PAGE>



STATE OF COLORADO )
                  )  ss.:
COUNTY OF DENVER  )


            On this 15 day of  November,  1991,  R. Dalton Sim,  known to me and
known  to be the  individual(s)  described  in and who  executed  the  foregoing
instrument,  personally  appeared before me and they severally  acknowledged the
foregoing instrument to be their free act and deed.



/s/ Cheryl K. Howlett
- ---------------------
    Cheryl K. Howlett
    Notary Public

My Commission Expires February 22, 1995.



STATE OF COLORADO )
                  )  ss.:
COUNTY OF DENVER  )


            On this 15 day of November,  1991,  Dan J.  Hesser,  known to me and
known  to be the  individual(s)  described  in and who  executed  the  foregoing
instrument,  personally  appeared before me and they severally  acknowledged the
foregoing instrument to be their free act and deed.



      /s/ Cheryl K. Howlett
      ---------------------
          Cheryl K Howlett
          Notary Public

My Commission Expires February 22, 1995.


      The undersigned,  being the sole initial  shareholder of The Global Health
Sciences  Fund  ("the  Fund")  acting  pursuant  to  Section  8.3 of the  Fund's
Declaration of Trust (the  "Declaration")  dated November 18, 1991, and pursuant
to Section 3.10 of the Fund's  Bylaws dated  December 5, 1991,  hereby amend the
Declaration as follows:

Section 2.2 is hereby amended and restated as follows:

      SECTION 2.2 TERM OF OFFICE OF  TRUSTEES.  The Board of  Trustees  shall be
divided into three classes. Within the limits above specified, the number of the
Trustees  in each  class  shall be  determined  by  resolution  of the  Board of
Trustees.  The term of office of all of the Trustees shall expire on the date of
the first annual or special meeting of Shareholders following the effective date
of the Registration Statement relating to the Shares under the Securities Act of
1933, as amended. The term of office of the first class shall expire on the date
of the second annual meeting of Shareholders or special meeting in lieu thereof.
The term of office of the  second  class  shall  expire on the date of the third
annual meeting of Shareholders  or special meeting in lieu thereof.  The term of
office of the third class shall expire on the date of the fourth annual  meeting
of shareholders or special meeting in lieu thereof.  Upon expiration of the term
of office of each class as set forth above, the number of Trustees in such class
as set forth above,  the number of Trustees in such class,  as determined by the
Board of Trustees, shall be elected for a term expiring on the date of the third
annual meeting of Shareholders or special meeting in lieu thereof following such
expiration to succeed the Trustees  whose terms of office  expire.  The Trustees
shall be elected at an annual meeting of the  Shareholders or special meeting in
lieu thereof called for that purpose,  except as provided in Section 2.3 of this
Article and each Trustee  elected  shall hold office until his or her  successor
shall have been  elected and shall have  qualified;  except (a) that any Trustee
may resign his trust  (without  need for prior or subsequent  accounting)  by an
instrument in writing signed by him or her and delivered to the other  Trustees,
which  shall  take  effect  upon such  delivery  or upon such  later  date as is
specified  therein;  (b) that any Trustee may be removed (provided the aggregate
number of Trustees after such removal shall not be less than the number required
by Section 2.1 hereof) for cause, at any time by written  instrument,  signed by
the  remaining  Trustees,  specifying  the date when such  removal  shall become
effective; and (c) that any Trustee who requests in writing to be retired or who
has  become  incapacitated  by  illness  or injury  may be  retired  by  written
instrument  signed by a majority of the other  Trustees,  specifying the date of
his retirement.  Upon the resignation or removal of a Trustee,  or his otherwise
ceasing to be Trustee, he or she shall execute and deliver such documents as the
remaining Trustees shall require for the purpose of conveying to the Fund or the
remaining  Trustees  any  Fund  property  held in the name of the  resigning  or
removed Trustee.  Upon the incapacity or death of any Trustee,  his or her legal
representative  shall execute and deliver on his or her behalf such documents as
the remaining Trustees shall require as provided in the preceding sentence.


<PAGE>


      IN WITNESS  WHEREOF,  the  undersigned  has executed this instrument as of
this January 15, 1992.


                                          INVESCO TRUST COMPANY




                                          By:   /s/ Ronald L. Grooms          
                                                --------------------          
ATTEST:                                         Ronald L. Grooms
                                                Senior Vice President
By:   /s/ Glen A. Payne
      ------------------------
      Glen A. Payne, Secretary




                                     BY-LAWS
                                       OF
                         THE GLOBAL HEALTH SCIENCES FUND
                        (a Massachusetts Business Trust)
                            Adopted November 18, 1991

                                    ARTICLE I

                                   DEFINITIONS
                                   -----------

            The terms "COMMISSION", "DECLARATION",  "DISTRIBUTOR", "FUND", "FUND
PROPERTY",  "INVESTMENT  ADVISER",  "MAJORITY  SHAREHOLDER  VOTE",  "1940  ACT",
"SHAREHOLDER",  "SHARES",  "TRANSFER AGENT",  and "TRUSTEES" have the respective
meanings  given them in the  Declaration of Trust of the Fund dated November 18,
1991, as amended from time to time.

                                   ARTICLE II

                                     OFFICES
                                     -------

            SECTION 2.1.  PRINCIPAL OFFICE.  Until changed by the Trustees,  the
principal  office of the Fund shall be 7800 E. Union Avenue,  Suite 800, Denver,
Colorado 80237.

            SECTION 2.2. OTHER OFFICES. In addition to its principal office, the
Fund may have an office or offices at such other  places  within and without the
Commonwealth of Massachusetts as the Trustees may from time to time designate or
the business of the Fund may require.

                                   ARTICLE III

                             SHAREHOLDERS' MEETINGS
                             ----------------------

            SECTION 3.1.  PLACE OF MEETINGS.  Meetings of  Shareholder  shall be
held at such place, within or without the Commonwealth of Massachusetts,  as may
be designated from time to time by the Trustees.

            SECTION 3.2. ANNUAL MEETINGS. Meetings of Shareholders, at which the
Shareholders  shall  elect  Trustees  and  transact  such other  business as may
properly come before the meeting,  shall be held annually so long as such annual
meetings  shall be required by the New York Stock Exchange or the other exchange
or trading system upon which Shares are principally traded.

            SECTION 3.3. SPECIAL  MEETINGS.  Special meetings of Shareholders of
the Fund shall be held whenever  called by the Board of Trustees or the Chairman
of the  Fund.  Special  meetings  of  Shareholders  shall  also be called by the
Secretary upon the written request of the holders of Shares entitled to vote not


<PAGE>


less than twenty-five percent (25%) of all the votes entitled to be cast at such
meeting.  Such  request  shall state the purpose or purposes of such meeting and
the matters  proposed to be acted on thereat.  The  Secretary  shall inform such
Shareholders  of the  reasonable  estimated  cost of preparing  and mailing such
notice  of the  meeting,  and,  upon  payment  to the  Fund of such  costs,  the
Secretary  shall give  notice  stating the purpose or purposes of the meeting to
all entitled to vote at such meeting. No special meeting need be called upon the
request of the  holders of Shares  entitled  to cast less than a majority of all
votes  entitled  to be cast at such  meeting,  to consider  any matter  which is
substantially  the  same as a  matter  voted  upon  at any  special  meeting  or
Shareholders held during the preceding twelve months.

            SECTION 3.4. NOTICE OF MEETINGS.  Written or printed notice of every
Shareholders'  meeting stating the place, date, and purpose or purposes thereof,
shall be given by the Secretary not less than ten (10) nor more than ninety (90)
days before such meeting to each  Shareholder  entitled to vote at such meeting.
Such  notice  shall be deemed to be given when  deposited  in the United  States
mail, postage prepaid,  directed to the Shareholder at his address as it appears
on the records of the Fund.

            SECTION 3.5. QUORUM AND ADJOURNMENT OF MEETINGS. Except as otherwise
provided by law, by the  Declaration  or by these  By-Laws,  at all  meetings of
Shareholders  the holders of a majority of the Shares issued and outstanding and
entitled to vote thereat,  present in person or represented  by proxy,  shall be
requisite and shall constitute a quorum for the transaction of business.  In the
absence  of a quorum,  the  Shareholders  present  or  represented  by proxy and
entitled to vote  thereat  shall have power to adjourn the meeting  from time to
time. Any adjourned  meeting may be held as adjourned without further notice. At
any  adjourned  meeting at which a quorum shall be present,  any business may be
transacted as if the meeting had been held as originally called.

            SECTION   3.6.   VOTING   RIGHTS,   PROXIES.   At  each  meeting  of
Shareholders,  each holder of record of Shares entitled to vote thereat shall be
entitled  to one  vote  in  person  or by  proxy,  executed  in  writing  by the
Shareholder  or  his  duly  authorized  attorney-in-fact,   for  each  Share  of
beneficial  interest of the Fund and for the fractional  portion of one vote for
each fractional  Share entitled to vote so registered in his name on the records
of the  Fund on the date  fixed as the  record  date  for the  determination  of
Shareholders  entitled  to vote at such  meeting.  No proxy shall be valid after
eleven  months from its date,  unless  otherwise  provided in the proxy.  At all
meetings of  Shareholders,  unless the voting is  conducted by  inspectors,  all
questions  relating to the  qualification  of voters and the validity of proxies
and the acceptance or rejection of votes shall be decided by the chairman of the
meeting. Pursuant to a resolution of a majority of the Trustees,  proxies may be
solicited in the name of one or more Trustees or officers of the Fund.

            SECTION 3.7. VOTE REQUIRED.  Except as otherwise provided by law, by
the Declaration of Trust,  or by these By-Laws,  at each meeting of Shareholders
at  which a  quorum  is  present,  all  matters  shall be  decided  by  Majority
Shareholder Vote.

            SECTION 3.8.  INSPECTORS  OF ELECTION.  In advance of any meeting of
Shareholders,  the  Trustees  may appoint  Inspectors  of Election to act at the


                                       2
<PAGE>


meeting  or any  adjournment  thereof.  If  Inspectors  of  Election  are not so
appointed,  the chairman of any meeting of Shareholders  may, and on the request
of any  Shareholder  or his proxy shall,  appoint  Inspectors of Election of the
meeting.  In case any person  appointed as Inspector fails to appear or fails or
refuses to act, the vacancy may be filled by appointment made by the Trustees in
advance of the  convening of the meeting or at the meeting by the person  acting
as chairman.  The  Inspectors of Election  shall  determine the number of Shares
outstanding,  the Shares represented at the meeting,  the existence of a quorum,
the authenticity,  validity and effect of proxies,  shall receive votes, ballots
or consents,  shall hear and determine all  challenges  and questions in any way
arising in connection with the right to vote, shall count and tabulate all votes
or consents,  determine the results,  and do such other acts as may be proper to
conduct the election or vote with  fairness to all  Shareholders.  On request of
the chairman of the meeting,  or of any Shareholder or his proxy, the Inspectors
of  Election  shall make a report in writing of any  challenge  or  question  or
matter  determined by them and shall execute a certificate of any facts found by
them.

            SECTION 3.9.  INSPECTION  OF BOOKS AND RECORDS.  Shareholders  shall
have such rights and  procedures  of  inspection of the books and records of the
Fund as are granted to Shareholders  under the Corporations and Associations law
of the Commonwealth of Massachusetts.

            SECTION 3.10.  ACTION BY  SHAREHOLDERS  WITHOUT  MEETING.  Except as
otherwise  provided by law, the provisions of these By-Laws  relating to notices
and meetings to the contrary  notwithstanding,  any action required or permitted
to be taken at any meeting of  Shareholders  may be taken without a meeting if a
majority of the  Shareholders  entitled  to vote upon the action  consent to the
action in writing and such consents are filed with the records of the Fund. Such
consent  shall be  treated  for all  purposes  as a vote  taken at a meeting  of
Shareholders.

                                   ARTICLE IV

                                    TRUSTEES
                                    --------

            SECTION  4.1.  MEETINGS OF THE  TRUSTEES.  The Trustees may in their
discretion  provide for regular or special  meetings  of the  Trustees.  Regular
meetings  of the  Trustees  may be held at such  time  and  place  as  shall  be
determined from time to time by the Trustees  without  further  notice.  Special
meetings of the  Trustees may be called at any time by the Chairman and shall be
called by the Chairman or the Secretary upon the written  request of any two (2)
Trustees.

            SECTION 4.2. NOTICE OF SPECIAL  MEETINGS.  Written notice of special
meetings of the Trustees,  stating the place,  date and time  thereof,  shall be
given  not  less  than  two (2)  days  before  such  meeting  to  each  Trustee,
personally,  by  telegram,  by mail,  or by leaving  such notice at his place of
residence or usual place of business.  If mailed, such notice shall be deemed to
be given when deposited in the United States mail, postage prepaid,  directed to
the Trustee at his address as it appears on the records of the Fund.  Subject to
the provisions of the 1940 Act,  notice or waiver of notice need not specify the
purpose of any special meeting.


                                       3
<PAGE>


            SECTION 4.3. TELEPHONE MEETINGS. Except as may otherwise be required
by law, any Trustee, or any member or members of any committee designated by the
Trustees, may participate in a meeting of the Trustees or any such committee, as
the case may be, by means of a conference  telephone  or similar  communications
equipment if all persons participating in the meeting can hear each other at the
same time.  Participation  in a meeting by these means  constitutes  presence in
person at the meeting.

            SECTION 4.4.  QUORUM,  VOTING AND  ADJOURNMENT  OF MEETINGS.  At all
meetings of the Trustees,  a majority of the Trustees  shall be requisite to and
shall  constitute  a quorum  for the  transaction  of  business.  If a quorum is
present, the affirmative vote of a majority of the Trustees present shall be the
act of the Trustees, unless the concurrence of a greater proportion is expressly
required for such action by law, the  Declaration  or these  By-Laws.  If at any
meeting  of the  Trustees  there be less  than a quorum  present,  the  Trustees
present thereat may adjourn the meeting from time to time,  without notice other
than announcement at the meeting, until the quorum shall have been obtained.

            SECTION 4.5. ACTION BY TRUSTEES WITHOUT  MEETING.  The provisions of
these By-Laws covering notices and meetings to the contrary notwithstanding, and
except as required by law,  any action  required or permitted to be taken at any
meeting of the Trustees  may be taken  without a meeting if a consent in writing
setting forth the action shall be signed by all of the Trustees entitled to vote
upon  the  action  and  such  written  consent  is filed  with  the  minutes  of
proceedings of the Trustees.

            SECTION  4.6.  EXPENSES  AND  FEES.  Each  Trustee  may  be  allowed
expenses,  if any,  for  attendance  at each  regular or special  meeting of the
Trustees,  and each  Trustee who is not an officer or employee of the Fund or of
its investment  manager or  underwriter or of any corporate  affiliate of any of
said persons shall  receive for services  rendered as a Trustee of the Fund such
compensation as may be fixed by the Trustees.  Nothing herein contained shall be
construed to preclude  any Trustee  from serving the Fund in any other  capacity
and receiving compensation therefor.

            SECTION 4.7.  EXECUTION OF INSTRUMENTS  AND DOCUMENTS AND SIGNING OF
CHECKS AND OTHER OBLIGATIONS AND TRANSFERS. All instruments, documents and other
papers  shall be  executed in the name and on behalf of the Fund and all checks,
notes,  drafts and other  obligations for the payment of money by the Fund shall
be signed,  and all  transfers  of  securities  standing in the name of the Fund
shall be executed,  by the President,  any Vice President or the Treasurer or by
any one or more officers or agents of the Fund as shall be  designated  for that
purpose by vote of the Trustees.

            SECTION 4.8.  INDEMNIFICATION OF TRUSTEES,  OFFICERS,  EMPLOYEES AND
                          AGENTS.

      (a)   As used in  these  By-Laws,  the  following  terms  shall  have  the
            meanings set forth below:


                                       4
<PAGE>


            (i)    the term  "indemnitee"  shall  mean  any  present  or  former
                   Trustee,  officer or  employee  of the Fund,  any  present or
                   former  Trustee,  partner,  Director  or  officer  of another
                   trust,   partnership,   corporation  or   association   whose
                   securities are or were owned by the Fund or of which the Fund
                   is or was a  creditor  and  who  served  or  serves  in  such
                   capacity  at  the  request  of  the  Fund,   and  the  heirs,
                   executors,  administrators,  successors and assigns of any of
                   the foregoing;  however, whenever conduct by an indemnitee is
                   referred  to,  the  conduct  shall  be that  of the  original
                   indemnitee   rather   than  that  of  the   heir,   executor,
                   administrator, successor or assignee;

            (ii)   the term  "covered  proceeding"  shall  mean any  threatened,
                   pending or  completed  action,  suit or  proceeding,  whether
                   civil, criminal, administrative or investigative, to which an
                   indemnitee  is or was a party or is  threatened  to be made a
                   party by reason of the fact or facts  under which he or it is
                   an indemnitee as defined above;

            (iii)  the term "disabling conduct" shall mean willful  misfeasance,
                   bad faith,  gross  negligence  or reckless  disregard  of the
                   duties involved in the conduct of the office in question;

            (iv)   the term "covered  expenses"  shall mean expenses  (including
                   attorneys'  fees),  judgments,  fines  and  amounts  paid  in
                   settlement  actually and reasonably incurred by an indemnitee
                   in connection with a covered proceeding; and

            (v)    the term  "adjudication  of liability"  shall mean, as to any
                   covered  proceeding  and as to  any  indemnitee,  an  adverse
                   determination  as to  the  indemnitee  whether  by  judgment,
                   order,  settlement,   conviction  or  upon  a  plea  of  nolo
                   contendere or its equivalent.

      (b)   The Fund shall not indemnify any indemnitee for any covered expenses
            in any  covered  proceeding  if there  has been an  adjudication  of
            liability against such indemnitee  expressly based on a finding of a
            disabling conduct.

      (c)   Except as set forth in paragraph (b) above, the Fund shall indemnify
            any  indemnitee  for covered  expenses  in any  covered  proceeding,
            whether  or not there is an  adjudication  of  liability  as to such
            indemnitee,  such  indemnification  by the Fund to be to the fullest
            extent now or hereafter  permitted by any  applicable law unless the
            By-Laws  limit  or  restrict  the   indemnification   to  which  any
            indemnitee  may be entitled.  The Board of Trustees may adopt By-Law
            provisions to implement paragraphs (a), (b) and (c) hereof.

      (d)   Nothing  herein  shall be  deemed  to  affect  the right of the Fund
            and/or any indemnitee to acquire and pay for any insurance  covering
            any or all indemnities to the extent  permitted by applicable law or


                                       5
<PAGE>


            to affect any other  indemnification  rights to which any indemnitee
            may be entitled to the extent  permitted  by  applicable  law.  Such
            rights to indemnification shall not, except as otherwise provided by
            law,  be  deemed  exclusive  of  any  other  rights  to  which  such
            indemnitee  may be entitled under any statute,  By-Law,  contract or
            otherwise.

      (e)   In case any  Shareholder or former  Shareholder  shall be held to be
            personally  liable  solely by  reason of his being or having  been a
            Shareholder  and not  because of his acts or  omissions  or for some
            other reason,  the Shareholder or former  Shareholder (or his heirs,
            executors,  administrators or other legal  representatives or in the
            case of a  corporation  or  other  entity,  its  corporate  or other
            general  successor)  shall be entitled  out of the Fund estate to be
            held  harmless  from and  indemnified  against  all loss and expense
            arising  from such  liability.  The Fund shall,  upon request by the
            Shareholder,  assume the defense of any such claim made  against any
            Shareholder  for any act or  obligation  of the Fund and satisfy any
            judgment thereon.

                                    ARTICLE V

                                   COMMITTEES
                                   ----------

            SECTION  5.1.  EXECUTIVE  AND OTHER  COMMITTEES.  The  Trustees,  by
resolution  adopted by a majority of the  Trustees,  may  designate an Executive
Committee and/or other committees,  each committee to consist of two (2) or more
of the  Trustees  of the  Fund  and  may  delegate  to such  committees,  in the
intervals  between  meetings  of the  Trustees,  any or all of the powers of the
Trustees in the  management  of the  business  and  affairs of the Fund.  In the
absence of any member of any such committee,  the members thereof present at any
meeting,  whether or not they constitute a quorum,  may appoint a Trustee to act
in place of such absent member.  Each such committee  shall keep a record of its
proceedings.

            The Executive  Committee and any other  committee  shall fix its own
rules or  procedures,  but the presence of at least fifty  percent  (50%) of the
members of the whole  committee  shall in each case be necessary to constitute a
quorum of the committee and the affirmative  vote of the majority of the members
of the committee present at the meeting shall be necessary to take action.

            All  actions of the  Executive  Committee  shall be  reported to the
Trustees at the meeting thereof next succeeding to the taking of such action.

            SECTION  5.2.  ADVISORY  COMMITTEE.  The  Trustees  may  appoint  an
advisory  committee which shall be composed of persons who do not serve the Fund
in any other  capacity and which shall have advisory  functions  with respect to
the  investments of the Fund but which shall have no power to determine that any
security or other investment shall be purchased,  sold or otherwise  disposed of
by the Fund.  The number of persons  constituting  any such  advisory  committee
shall be determined  from time to time by the Trustees.  The members of any such


                                       6
<PAGE>


advisory  committee  may  receive  compensation  for their  services  and may be
allowed such fees and expenses  for the  attendance  at meetings as the Trustees
may from time to time determine to be appropriate.

            SECTION 5.3.  COMMITTEE  ACTION WITHOUT  MEETING.  The provisions of
these By-Laws covering notices and meetings to the contrary notwithstanding, and
except as required by law,  any action  required or permitted to be taken at any
meeting of any  Committee of the Trustees  appointed  pursuant to Section 5.1 of
these  By-Laws  may be taken  without a meeting if a consent in writing  setting
forth the action  shall be signed by all  members of the  Committee  entitled to
vote upon the action and such  written  consent is filed with the records of the
proceedings of the Committee.

                                   ARTICLE VI

                                    OFFICERS
                                    --------

            SECTION 6.1. EXECUTIVE OFFICERS.  The executive officers of the Fund
shall be a Chairman, a President, one or more Vice Presidents, a Secretary and a
Treasurer.  The Chairman  shall be selected  from among the Trustees but none of
the other  executive  officers need be a Trustee.  Two or more  offices,  except
those of President and any Vice President,  may be held by the same person,  but
no officer shall execute,  acknowledge or verify any instrument in more than one
capacity.

            The executive  officers of the Fund shall be elected annually by the
Trustees  and each  executive  officer so elected  shall hold  office  until his
successor is elected and has qualified.

            SECTION 6.2. OTHER OFFICERS AND AGENTS.  The Trustees may also elect
one or more  Assistant  Vice  Presidents,  Assistant  Secretaries  and Assistant
Treasurers and may elect, or may delegate to the President the power to appoint,
such other officers and agents as the Trustees shall at any time or from time to
time deem advisable.

            SECTION 6.3. TERM,  REMOVAL AND VACANCIES.  Each officer of the Fund
shall hold office until his successor is elected and has qualified.  Any officer
or agent of the Fund may be removed by the Trustees whenever, in their judgment,
the best interests of the Fund will be served thereby, but such removal shall be
without prejudice to the contractual rights, if any, of the person so removed.

            SECTION 6.4. COMPENSATION OF OFFICERS.  The compensation of officers
and agents of the Fund shall be fixed by the  Trustees,  or by the  President to
the extent  provided by the Trustees  with respect to officers  appointed by the
President.

            SECTION 6.5. POWER AND DUTIES.  All officers and agents of the Fund,
as between  themselves and the Fund,  shall have such authority and perform such
duties in the  management of the Fund as may be provided in or pursuant to these
By-Laws, or to the extent not so provided, as may be prescribed by the Trustees;


                                       7
<PAGE>


provided, that no rights of any third party shall be affected or impaired by any
such By-Law or resolution of the Trustees unless he has knowledge thereof.

            SECTION  6.6.  THE  CHAIRMAN.  The  Chairman  shall  preside  at all
meetings of the  Shareholders  and of the  Trustees,  and he shall  perform such
other duties as the Trustees may from time to time prescribe.

            SECTION  6.7.  THE  PRESIDENT.  The  President  shall  be the  chief
executive  officer of the Fund;  he shall have general and active  management of
the  business  of the Fund,  shall see that all  orders and  resolutions  of the
Trustees  are carried  into  effect,  and,  in  connection  therewith,  shall be
authorized  to  delegate to one or more Vice  Presidents  such of his powers and
duties at such times and in such manner as he may deem advisable.

            SECTION 6.8. THE VICE  PRESIDENTS.  The Vice Presidents  shall be of
such number and shall have such titles as may be determined from time to time by
the  Trustees.  The Vice  President,  or, if there be more  than  one,  the Vice
Presidents  in the order of their  seniority as may be  determined  from time to
time by the Trustees or the  President,  shall,  in the absence or disability of
the President,  exercise the powers and perform the duties of the President, and
he or they shall  perform such other duties as the Trustees or the President may
from time to time prescribe.

            SECTION 6.9. THE  ASSISTANT  VICE  PRESIDENTS.  The  Assistant  Vice
President,  or, if there be more than one, the Assistant Vice Presidents,  shall
perform such duties and have such powers as may be assigned from time to time by
the Trustees or the President.

            SECTION 6.10. THE SECRETARY. The Secretary shall attend all meetings
of the  Trustees  and  all  meetings  of the  Shareholders  and  record  all the
proceedings of the meetings of the Shareholders and of the Trustees in a book to
be kept for that  purpose,  and  shall  perform  like  duties  for the  standing
committees  when  required.  He shall give, or cause to be given,  notice of all
meetings of the  Shareholders  and special  meetings of the Trustees,  and shall
perform  such  other  duties  and  have  such  powers  as the  Trustees,  or the
President,  may from time to time  prescribe.  He shall keep in safe custody the
seal of the Fund and affix or cause  the same to be  affixed  to any  instrument
requiring it, and, when so affixed,  it shall be attested by his signature or by
the signature of an Assistant Secretary.

            SECTION 6.11. THE ASSISTANT  SECRETARIES.  The Assistant  Secretary,
or, if there be more than one, the Assistant Secretaries in the order determined
by the Trustees or the  President,  shall,  in the absence or  disability of the
Secretary, perform the duties and exercise the powers of the Secretary and shall
perform such duties and have such other powers as the Trustees or the  President
may from time to time prescribe.

            SECTION  6.12.  THE  TREASURER.  The  Treasurer  shall be the  chief
financial  officer  of the  Fund.  He shall  keep or  cause to be kept  full and
accurate  accounts of receipts and disbursements in books belonging to the Fund,
and he shall  render to the  Trustees  and the  President,  whenever any of them


                                       8
<PAGE>


require it, an account of his  transactions  as Treasurer  and of the  financial
condition of the Fund;  and he shall  perform such other duties as the Trustees,
or the President, may from time to time prescribe.

            SECTION 6.13. THE ASSISTANT TREASURERS. The Assistant Treasurer, or,
if  there  shall  be more  than  one,  the  Assistant  Treasurers  in the  order
determined by the Trustees or the President, shall, in the absence or disability
of the  Treasurer,  perform the duties and exercise the powers of the  Treasurer
and shall  perform such other duties and have such other powers as the Trustees,
or the President, may from time to time prescribe.

            SECTION 6.14. DELEGATION OF DUTIES. Whenever an officer is absent or
disabled,  or whenever for any reason the Trustees  may deem it  desirable,  the
Trustees  may  delegate  the powers and duties of an officer or  officers to any
other officer or officers or to any Trustee or Trustees.

                                   ARTICLE VII

                           DIVIDENDS AND DISTRIBUTIONS
                           ---------------------------

            Subject to any  applicable  provisions  of law and the  Declaration,
dividends and distributions upon the Shares may be declared at such intervals as
the Trustees may  determine,  in cash, in securities  or other  property,  or in
Shares,  from any sources  permitted by law, all as the Trustees shall from time
to time determine.

            Inasmuch as the  computation  of the net income and net profits from
the sale of securities or other  properties  for federal income tax purposes may
vary from the computation thereof on the records of the Fund, the Trustees shall
have power,  in their  discretion,  to  distribute  as income  dividends  and as
capital gain distributions,  respectively, amounts sufficient to enable the Fund
to avoid or reduce liability for federal income taxes.

                                  ARTICLE VIII

                             CERTIFICATES OF SHARES
                             ----------------------

            SECTION 8.1. CERTIFICATES OF SHARES.  Certificates for Shares of the
Fund shall be in such form and of such  design as the  Trustees  shall  approve,
subject to the right of the  Trustees to change such form and design at any time
or from time to time,  and shall be entered  in the  records of the Fund as they
are issued.  Each such  certificate  shall bear a distinguishing  number;  shall
exhibit the  holder's  name and certify the number of full Shares  owned by such
holder;  shall be  signed by or in the name of the Fund by the  President,  or a
Vice President,  and countersigned by the Secretary or an Assistant Secretary or
the Treasurer and an Assistant  Treasurer of the Fund;  shall be sealed with the
seal;  and shall  contain  such  recitals as may be  required by law.  Where any
certificate  is signed by a Transfer  Agent or by a Registrar,  the signature of
such officers and the seal may be facsimile,  printed or engraved. The Fund may,
at its option,  determine not to issue a certificate or certificates to evidence
Shares owned of record by any Shareholder.


                                       9
<PAGE>


            In case any  officer or  officers  who shall have  signed,  or whose
facsimile  signature  or  signatures  shall appear on, any such  certificate  or
certificates  shall cease to be such  officer or  officers of the Fund,  whether
because  of  death,  resignation  or  otherwise,   before  such  certificate  or
certificates  shall  have  been  delivered  by the  Fund,  such  certificate  or
certificates  shall,  nevertheless,  be  adopted  by the Fund and be issued  and
delivered  as though the  person or  persons  who  signed  such  certificate  or
certificates or whose facsimile signature or signatures shall appear therein had
not ceased to be such officer or officers of the Fund.

            No  certificate  shall be issued  for any Share  until such Share is
fully paid.

            SECTION 8.2. TRANSFER OF SHARES. Shares shall be transferable on the
books of the Fund by the  holder  thereof  in person  or by his duly  authorized
attorney  or  legal   representative,   upon  surrender  and   cancellation   of
certificates,  if  any,  for  the  same  number  of  Shares,  duly  endorsed  or
accompanied by proper instruments of assignment and transfer, with such proof of
the  authenticity  of the  signature  as the Fund or its  agent  may  reasonably
require;  in the case of Shares not  represented  by  certificates,  the same or
similar requirements may be imposed by the Board of Trustees.

            SECTION  8.3.  SHARE  LEDGERS.   The  share  ledgers  of  the  Fund,
containing the name and address of the  Shareholders  of the Fund and the number
of Shares held by them  respectively,  shall be kept at the principal offices of
the Fund or,  if the Fund  employs  a  transfer  agent,  at the  offices  of the
Transfer Agent of the Fund.

            SECTION 8.4. LOST, STOLEN, DESTROYED AND MUTILATED CERTIFICATES. The
Trustees may direct a new  certificate or  certificates to be issued in place of
any certificate or certificates  theretofore  issued by the Fund alleged to have
been lost, stolen or destroyed,  upon satisfactory proof of such loss, theft, or
destruction; and the Trustees may, in their discretion, require the owner of the
lost, stolen or destroyed certificate,  or his legal representative,  to give to
the Fund and to such  Registrar,  Transfer Agent and/or Transfer Clerk as may be
authorized or required to countersign  such new certificate or  certificates,  a
bond in such sum and of such type as they may  direct,  and with such  surety or
sureties, as they may direct, as indemnity against any claim that may be against
them or any of them on account of or in connection with the alleged loss,  theft
or destruction of any such certificate.

                                   ARTICLE IX

                                WAIVER OF NOTICE
                                ----------------

            Whenever any notice of the time,  place or purpose of any meeting of
Shareholders,  Trustees,  or  of  any  committee  is  required  to be  given  in
accordance with law or under the provisions of the Declaration or these By-Laws,
a waiver  thereof in writing,  signed by the person or persons  entitled to such
notice and filed with the records of the  meeting,  whether  before or after the


                                       10
<PAGE>


holding thereof,  or actual attendance at the meeting of Shareholders,  Trustees
or committee,  as the case may be, in person,  shall be deemed equivalent to the
giving of such notice to such person.

                                    ARTICLE X

                                  MISCELLANEOUS
                                  -------------

            SECTION 10.1.  LOCATION OF BOOKS AND RECORDS.  The books and records
of the Fund may be kept outside the  Commonwealth of Massachusetts at such place
or places as the Trustees may from time to time  determine,  except as otherwise
required by law.

            SECTION 10.2. RECORD DATE. The Trustees may fix in advance a date as
the record date for the purpose of determining  Shareholders  entitled to notice
of, or to vote at, any  meeting of  Shareholders,  or  Shareholders  entitled to
receive  payment of any dividend or the allotment of any rights,  or in order to
make a determination of Shareholders for any other proper purpose. Such date, in
any case,  shall be not more than ninety (90) days,  and in case of a meeting of
Shareholders  not less than ten (10) days, prior to the date on which particular
action  requiring such  determination of Shareholders is to be taken. In lieu of
fixing a record date,  the Trustees may provide that the transfer books shall be
closed for a stated period but not to exceed,  in any case, twenty (20) days. If
the  transfer  books are closed  for the  purpose  of  determining  Shareholders
entitled to notice of a vote at a meeting of  Shareholders,  such books shall be
closed for at least ten (10) days immediately preceding such meeting.

            SECTION 10.3.  SEAL. The Trustees shall adopt a seal, which shall be
in such form and shall have such  inscription  thereon as the  Trustees may from
time to time provide.  The seal of the Fund may be affixed to any document,  and
the seal and its attestation may be lithographed,  engraved or otherwise printed
on any document  with the same force and effect as if it had been  imprinted and
attested  manually  in the same  manner and with the same effect as if done by a
Massachusetts business trust under Massachusetts law.

            SECTION 10.4.  FISCAL YEAR. The fiscal year of the Fund shall end on
such date as the Trustees  may by  resolution  specify,  and the Trustees may by
resolution change such date for future fiscal years at any time and from time to
time.

            SECTION   10.5.   ORDERS  FOR  PAYMENT  OF  MONEY.   All  orders  or
instructions  for the  payment  of money  of the  Fund,  and all  notes or other
evidences  of  indebtedness  issued in the name of the Fund,  shall be signed by
such  officer or officers or such other  person or persons as the  Trustees  may
from  time to time  designate,  or as may be  specified  in or  pursuant  to the
agreement  between the Fund and the bank or trust company appointed as Custodian
of the securities and funds of the Fund.


                                       11
<PAGE>

                                   ARTICLE XI

                       COMPLIANCE WITH FEDERAL REGULATIONS
                       -----------------------------------

            The  Trustees  are hereby  empowered to take such action as they may
deem to be necessary,  desirable or  appropriate so that the Fund is or shall be
in compliance  with any federal or state statute,  rule or regulation with which
compliance by the Fund is required.

                                   ARTICLE XII

                                   AMENDMENTS
                                   ----------

            These By-Laws may be amended,  altered, or repealed,  or new By-Laws
may be adopted,  (a) by a Majority  Shareholder  Vote,  or (b) by the  Trustees;
provided,  however,  that no By-Law may be  amended,  adopted or repealed by the
Trustees if such amendment,  adoption or repeal  requires,  pursuant to law, the
Declaration, or these By-Laws, a vote of the Shareholders. The Trustees shall in
no event adopt  By-Laws  which are in  conflict  with the  Declaration,  and any
apparent  inconsistency shall be construed in favor of the related provisions in
the Declaration.

                                  ARTICLE XIII

                              DECLARATION OF TRUST
                              --------------------


            The Declaration of Trust  establishing  the Fund, dated November 18,
1991, a copy of which is on file in the office of the  Secretary of State of the
Commonwealth of Massachusetts, provides that the name The Global Health Sciences
Fund refers to the Trustees under the Declaration  collectively as Trustees, but
not as individuals or personally; and no Trustee, Shareholder, officer, employee
or agent of the Fund shall be held to any personal  liability,  nor shall resort
be had to their private property for the satisfaction of any obligation or claim
or otherwise,  in connection  with the affairs of said Fund, but the Fund Estate
only shall be liable.


                                       12




TERMS AND CONDITIONS OF
INVESCO GLOBAL HEALTH SCIENCES FUND
DIVIDEND REINVESTMENT PLAN
(as amended)

All shareholders participating (the "Participants") in the Dividend Reinvestment
Plan (the "Plan") of INVESCO  Global  Health  Sciences Fund (the "Fund") will be
bound by the following provisions:

1.    State Street Bank and Trust  Company (the  "Agent")  will act as Agent for
      each Participant,  and will open an account for each Participant under the
      Plan in the same name as their present shares are registered, and put into
      effect  for them the  dividend  reinvestment  option of the Plan as of the
      first record date for a dividend, capital gains or other distribution.

2.    Whenever  the Fund  declares an income  dividend,  capital  gains or other
      distribution payable solely in shares, or in shares of the Fund or cash at
      the option of the shareholders, each Participant shall take such dividend,
      capital gains or other  distribution  entirely in shares.  The Agent shall
      automatically   receive  such  shares,   including  fractions,   for  each
      Participant's  account.  The number of additional shares to be credited to
      each  Participant's  account  shall be  determined  by dividing the dollar
      amount of the  dividend,  capital gains or other  distribution  payable on
      their shares by the greater of the net asset value per share determined as
      of the date of purchase or 95% of the then-current  market price per share
      of the Fund's  shares on the payment  date.  The payment date shall be the
      payable date for such dividend,  capital gains or other  distribution,  or
      such prior date as may be determined by the board of trustees of the Fund.

3.    In the event that the Fund  declares a  dividend,  capital  gains or other
      distribution  payable only in cash, the Agent shall, except as provided in
      the next succeeding paragraph,  apply the amount of such dividend, capital
      gains or other  distribution  payable on the shares of each participant in
      the Plan (less his or her pro rata share of brokerage commissions incurred
      with respect to the Agent's  open-market  purchases in connection with the
      reinvestment of such dividend, capital gains or other distribution) to the
      purchase on the open market of shares of the Fund for his or her  account.
      Such  purchases will be made on or shortly after the payment date for such
      dividend,  capital gains or other distribution,  and in no event more than
      30 days after such date except where  temporary  curtailment or suspension
      of purchases is necessary to comply with applicable  provisions of federal
      securities law.

      In the event that, at the time of payment of the distribution or dividend,
      or prior to the Agent's  completion  of all such  purchases  necessary  in
      connection with such dividend,  capital gains or other  distribution,  the
      market price of a share  equals or exceeds its net asset  value,  then the
      Agent shall not purchase  shares of the Fund in the open market,  or shall
      cease purchasing  shares of the Fund and the Fund will issue the remaining


<PAGE>


      shares necessary for the payment of such dividend,  capital gains or other
      distribution  at the  greater  of net asset  value per share or 95% of the
      then current market value of the shares of the Fund.

      In a case where, in accordance with the preceding paragraph, the Agent has
      terminated  open-market  purchases  and the Fund has issued the  remaining
      shares,  the number of shares of the Fund received by the  participants in
      respect of such  dividend,  capital  gains or other  distribution  will be
      based on the weighted  average of prices paid for shares  purchased in the
      open market and the prices at which the Fund issued the remaining shares.

4.    For purposes of making the dividend reinvestment purchase comparison under
      the Plan,  (a) the market price of the Fund's shares on a particular  date
      shall be the last sales price on the New York Stock Exchange on that date,
      or,  if  there is no sale on such  Exchange  on that  date,  then the mean
      between  the  closing  bid and asked  quotations  for such  shares on such
      Exchange  on such date and (b) the net asset value per share of the Fund's
      shares on a  particular  date shall be the net asset  value per share most
      recently calculated by or on behalf of the Fund.

5.    Open-market  purchases  provided  for above may be made on any  securities
      exchange  where the Fund's  shares  are  traded,  in the  over-the-counter
      market or in negotiated transactions and may be on such terms as to price,
      delivery and otherwise as the Agent shall  determine.  Each  Participant's
      uninvested  funds  held by the  Agent  will not bear  interest,  and it is
      understood  that,  in any  event,  the Agent  shall have no  liability  in
      connection  with any inability to purchase shares within 30 days after the
      initial date of such  purchase as herein  provided,  or with the timing of
      any purchases  effected.  The Agent shall have no responsibility as to the
      value of the Fund's shares acquired for each  Participant's  account.  For
      the  purpose  of  cash   investments,   the  Agent  may   commingle   each
      Participant's  funds with those of other shareholders of the Fund for whom
      the  Agent  similarly  acts as Agent,  and the  average  price  (including
      brokerage commissions) of all shares purchased by the Agent as Agent shall
      be the  price  per  share  allocated  to each  Participant  in  connection
      therewith.

6.    The Agent may hold each Participant's shares acquired pursuant to the Plan
      together  with the  shares  of  other  shareholders  of the Fund  acquired
      pursuant to the Plan in  noncertificated  form in the Agent's name or that
      of the Agent's  nominee.  The Agent will forward to each  Participant  any
      proxy  solicitation  material;  and will vote any  shares so held for each
      Participant first in accordance with the instructions set forth on proxies
      returned  by the  Participant  to the Fund,  and then with  respect to any
      proxies not returned by the Participant to the Fund in the same proportion
      as the agent votes proxies  returned by the Participants to the Fund. Upon
      a Participant's  written request,  the Agent will deliver to them, without
      charge, a certificate or certificates for the full shares.

7.    The Agent will confirm to each Participant each acquisition made for their
      account as soon as  practicable  but not later than 60 days after the date
      thereof. Although each Participant may from time to time have


<PAGE>


      an undivided  fractional  interest (computed to three decimal places) in a
      share of the Fund, no certificates  for a fractional share will be issued.
      However,  dividends,  capital gains and other  distributions on fractional
      shares  will be credited to each  Participant's  account.  In the event of
      termination  of a  Participant's  account  under the Plan,  the Agent will
      adjust for any such  undivided  fractional  interest in cash at the market
      value of the Fund's shares at the time of termination.

8.    Any share dividends or split shares distributed by the Fund on shares held
      by the Agent for a Participant  will be credited to their account.  In the
      event that the Fund makes available to its shareholders rights to purchase
      additional  shares  of  other   securities,   the  shares  held  for  each
      Participant  under the Plan will be added to other  shares held by them in
      calculating the number of rights to be issued to each Participant.

9.    The Agent's  service fee for handling  dividends,  capital  gains or other
      distributions  will be paid by the Fund. Each  Participant will be charged
      their pro rata share of brokerage commissions on all open-market purchases
      in connection with the  reinvestment of dividends,  capital gains or other
      distributions.

10.   Each  Participant  may terminate their account under the Plan by notifying
      the Agent in writing.  Such termination  will be effective  immediately if
      the  Participant's  notice is  received  by the Agent not less than thirty
      days prior to any  dividend,  capital gains or other  distribution  record
      date.  Otherwise  such  termination  will be effective  shortly  after the
      investment of such distributions with respect to any subsequent  dividend,
      capital  gains or other  distribution.  The Plan may be  terminated by the
      Agent or the Fund upon  notice in writing  mailed to each  Participant  at
      least 90 days prior to any record  date for the  payment of any  dividend,
      capital gains or other distribution by the Fund. Upon any termination, the
      Agent will cause a certificate or  certificates  to be issued for the full
      shares held for each  Participant  under the Plan and cash  adjustment for
      any  fraction to be delivered to them  without  charge.  If a  Participant
      elects by notice to the Agent in writing in advance of such termination to
      have the Agent sell part or all of their  shares and remit the proceeds to
      them,  the  Agent  is  authorized  to  deduct a $2.50  fee plus  brokerage
      commission for this transaction from the proceeds.

11.   These terms and conditions may be amended or  supplemented by the Agent or
      the Fund at any time or times but, except when necessary or appropriate to
      comply with  applicable law or the rules or policies of the Securities and
      Exchange Commission or any other regulatory authority,  only by mailing to
      each Participant  appropriate written notice at least 45 days prior to the
      effective date thereof.  The amendment or supplement shall be deemed to be
      accepted by each Participant unless,  prior to the effective date thereof,
      the Agent  receives  written  notice of the  termination  of their account
      under the Plan. Any such amendment may include an appointment by the Agent
      in its  place  and  stead of a  successor  Agent  under  these  terms  and
      conditions,  with full power and  authority  to perform  all or any of the
      acts to be performed by the Agent under these terms and  conditions.  Upon
      any such appointment of any Agent for the purpose of receiving  dividends,


<PAGE>


      capital gain and other  distributions,  the Fund will be authorized to pay
      to such successor Agent, for each  Participant's  account,  all dividends,
      capital gains and other  distributions  payable on shares of the Fund held
      in their  name or under  the Plan for  retention  or  application  by such
      successor Agent as provided in these terms and conditions.

12.   The Agent  shall at all times act in good  faith and agree to use its best
      efforts  within  reasonable  limits to ensure the accuracy of all services
      performed  under this  Agreement  and to comply with  applicable  law, but
      assumes no  responsibility  and shall not be liable for loss or damage due
      to errors  unless  such  error is caused by the  Agent's  negligence,  bad
      faith, or willful misconduct or that of its employees.

13.   These terms and  conditions  shall be governed by the laws of the State of
      New York.


<PAGE>


INVESCO GLOBAL HEALTH SCIENCES FUND



Dividend Reinvestment Plan



INVESCO GLOBAL HEALTH SCIENCES FUND
7800 E. Union Avenue
Suite 800
Denver, Colorado  80237


Investment Adviser:
INVESCO TRUST COMPANY
7800 E. Union Avenue
Suite 800
Denver, Colorado  80237
1-800-525-8085


Administrator:
INVESCO Funds Group, Inc.
7800 E. Union Avenue
Denver, CO 80237
1-303-930-6300


Shareholder Inquiries to:
STATE STREET BANK and TRUST COMPANY
c/o INVESCO Global Health Sciences Fund
P.O. Box 8209, Boston, MA  02266-8209
Telephone 1-800-451-6788


                          INVESTMENT ADVISORY AGREEMENT

   THIS AGREEMENT is made this 4th day of February,  1998, in Denver,  Colorado,
by  and  between  INVESCO  FUNDS  GROUP,   INC.  (the  "Adviser"),   a  Delaware
corporation,  and INVESCO Global Health Sciences Fund, a Massachusetts  business
trust (the "Fund").

                                   WITNESSETH:

   WHEREAS, the Fund is organized as a Massachusetts business trust; and

   WHEREAS,  the Fund is registered under the Investment Company Act of 1940, as
amended (the "1940 Act"),  as a diversified,  closed end  management  investment
company and currently has one class of shares (the "Shares"); and

   WHEREAS,  the Fund desires that the Adviser manage its investment  operations
and provide  certain  other  services,  and the  Adviser  desires to manage said
operations and to provide such other services;

   NOW,  THEREFORE,  in  consideration  of  these  premises  and of  the  mutual
covenants and  agreements  hereinafter  contained,  the parties  hereto agree as
follows:

1. INVESTMENT MANAGEMENT SERVICES.

   (a) The Adviser  hereby  agrees to manage the  investment  operations  of the
Fund,  subject  to the terms of this  Agreement  and to the  supervision  of the
Fund's board of trustees (the  "Trustees").  The Adviser  agrees to perform,  or
arrange for the performance of, the following specific services for the Fund:

   (i) to manage the  investment  and  reinvestment  of all the  assets,  now or
hereafter  acquired,  of the Fund,  and to execute  all  purchases  and sales of
portfolio securities;

   (ii) to maintain a  continuous  investment  program for the Fund,  consistent
with (A) the Fund's investment  policies as set forth in the Fund's  Declaration
of  Trust,  By Laws  and  Registration  Statement  under  the  1940  Act and the
Securities  Act of 1933 and (B) the  Fund's  status  as a  regulated  investment
company under the Internal Revenue Code of 1886, as amended;

   (iii) to determine what  securities are to be purchased or sold for the Fund,
unless  otherwise  directed  by  the  Trustees,   and  to  execute  transactions
accordingly;

   (iv) to provide to the Fund the benefit of all of the investment analysis and
research,  the reviews of current  economic  conditions  and of trends,  and the

<PAGE>

consideration  of  long  range  investment  policy  now or  hereafter  generally
available to investment advisory customers of the Adviser;

   (v) to  determine  what portion of the Fund should be invested in the various
types of securities authorized for purchase by the Fund;

   (vi) to make recommendations as to the manner in which voting rights,  rights
to  consent  to Fund  action  and any  other  rights  pertaining  to the  Fund's
securities shall be exercised; and

   (vii) to prepare proxy materials for meetings of the Fund's  shareholders and
such registrations and reports as may be required by federal securities laws.

   (b) With respect to execution of  transactions  for the Fund,  the Adviser is
authorized  to employ  such  brokers or dealers as may,  in the  Adviser's  best
judgment,  implement  the  policy  of the Fund to  obtain  prompt  and  reliable
execution at the most favorable price  obtainable.  In assigning an execution or
negotiating  the  commission to be paid  therefor,  the Adviser is authorized to
consider  the full range and quality of a broker's  services  which  benefit the
Fund,  including  but not  limited  to  research  and  analytical  capabilities,
reliability of performance, and financial soundness and responsibility. Research
services  prepared and furnished by brokers  through  which the Adviser  effects
securities  transactions  on  behalf of the Fund may be used by the  Adviser  in
servicing  all of its  accounts,  and not all such  services  may be used by the
Adviser in connection  with the Fund. In the selection of a broker or dealer for
execution  of any  negotiated  transaction,  the  Adviser  shall have no duty or
obligation to seek advance competitive bidding for the most favorable negotiated
commission  rate for such  transaction,  or to select any  broker  solely on the
basis of its  purported  or  "posted"  commission  rate  for  such  transaction,
provided,  however,  that the Adviser shall  consider  such "posted"  commission
rates, if any, together with any other  information  available at the time as to
the level of commissions known to be charged on comparable transactions by other
qualified   brokerage   firms,  as  well  as  all  other  relevant  factors  and
circumstances,  including  the  size  of  any  contemporaneous  market  in  such
securities, the importance to the Fund of speed, efficiency, and confidentiality
of execution,  the execution  capabilities  required by the circumstances of the
particular transactions,  and the apparent knowledge or familiarity with sources
from or to whom such  securities may be purchased or sold.  Where the commission
rate reflects  services,  reliability and other relevant  factors in addition to
the cost of execution,  the Adviser shall have the burden of demonstrating  that
such expenditures were bona fide and for the benefit of the Fund.

   2. FUND  ADMINISTRATION AND ALLOCATION OF EXPENSES.  The Adviser shall at its
expense provide all executive, administrative and clerical personnel as shall be
required to provide effective administration for the Fund, except such services,
facilities and personnel as the Fund shall obtain pursuant to the Administration
Agreement  annexed  hereto as Exhibit A.  Services to be provided by the Adviser
hereunder  shall include the  compilation  and  maintenance of such records with

                                        2


<PAGE>


respect to the Fund's operations as may reasonably be required,  other than such
books and records to be maintained by INVESCO Funds Group,  Inc. under the terms
of the Administration Agreement; the preparation and filing of such reports with
respect  thereto as shall be required by the Securities and Exchange  Commission
(the  "SEC")  and  periodic  reports  with  respect  to its  operations  for the
shareholders of the Fund except required  reports to shareholders and Form N-SAR
(or such other form as the SEC may  substitute  therefor);  preparation of proxy
materials for meetings of the Fund  shareholders;  and the  preparation  of such
registrations  and reports as may be required by federal  securities  laws.  The
Adviser shall, at its own cost and expense,  also provide the Fund with adequate
office  space,  facilities  and  equipment.  All other  costs and  expenses  not
expressly assumed by the Adviser under this Agreement shall be paid by the Fund,
including,  but not  limited  to (i)  interest  and taxes,  including  issue and
transfer taxes,  incurred by or levied on the Fund; (ii) insurance  premiums for
fidelity and other coverage requisite to its operations;  (iii) compensation and
expenses of its Trustees  other than those  associated  or  affiliated  with the
Adviser;  (iv) legal and audit expenses;  (v) custodian,  dividend paying agent,
registrar and transfer agent fees and expenses  (including  charges and expenses
of the Fund's Dividend  Reinvestment Plan Agent) and brokerage  commissions,  if
any; (vi) fees and expenses, other than as hereinabove provided, incident to the
registration,  under  Federal law, of shares of the Fund for public sale;  (vii)
except as noted above, all other expenses  incidental to holding meetings of the
Fund's shareholders;  (viii) payments under the Fund's Administration Agreement;
(ix) fees and  expenses  of listing  and  maintaining  the listing of the Fund's
shares  on  any  national   securities   exchange;   (x)  cost  of  certificates
representing  the Fund's  shares;  and (xi) such  nonrecurring  expenses  as may
arise, including litigation affecting the Fund and the legal obligation that the
Fund may have to indemnity its officers and Trustees with respect thereto.

   3. USE OF  AFFILIATED  COMPANIES.  In  connection  with the  rendering of the
services  required  to be  provided by the  Adviser  under this  Agreement,  the
Adviser may, to the extent it deems  appropriate  and subject to compliance with
the requirements of applicable laws and regulations, and upon receipt of written
approval of the Fund, make use of its affiliated  companies and their employees;
provided that the Adviser shall  supervise and remain fully  responsible for all
such services in accordance  with and to the extent  provided by this  Agreement
and that all costs and expenses associated with the providing of services by any
such  companies or employees  and required by this  Agreement to be borne by the
Adviser shall be borne by the Adviser or its affiliated companies.

   4.  COMPENSATION  OF THE  ADVISER For the  services  to be  rendered  and the
charges and expenses to be assumed by the Adviser hereunder,  the Fund shall pay
to the  Adviser a  monthly  fee at an  annual  rate of 1.00% of the  first  $500
million of the Fund's  ending  weekly net assets and 0.90% of the Fund's  ending
weekly net assets in excess of $500  million.  The fee  provided  for  hereunder
shall be prorated in any month in which this  Agreement is not in effect for the
entire month.

                                        3


<PAGE>


   5.  AVOIDANCE  OF  INCONSISTENT   POSITIONS  AND  COMPLIANCE  WITH  LAWS.  In
connection with purchases or sales of securities for the investment portfolio of
the Fund,  neither  the  Adviser nor its  officers  or  employees  will act as a
principal or agent for any party other than the Fund or receive any commissions.
The Adviser will comply with all applicable laws in acting hereunder  including,
without  limitation,  the 1940 Act;  the  Investment  Advisers  Act of 1940,  as
amended; and all rules and regulations duly promulgated under the foregoing.

   6. DURATION AND TERMINATION.  THIS Agreement shall become effective as of the
date it is approved by a majority of the  outstanding  voting  securities of the
Fund,  and unless sooner  terminated as  hereinafter  provided,  shall remain in
force for an initial term ending two years from the date of execution,  and from
year to year  thereafter,  but only as long as such  continuance is specifically
approved at least annually (i) by a vote of a majority of the outstanding voting
securities  of the  Fund  or by the  Trustees,  and  (ii) by a  majority  of the
Trustees who are not interested persons of the Adviser or the Fund by votes cast
in person at a meeting called for the purpose of voting on such approval.

   This Agreement may, on 60 days' prior written notice,  be terminated  without
the payment of any penalty, by the Trustees, or by the vote of a majority of the
outstanding  voting  securities  of the  Fund,  as the  case  may be,  or by the
Adviser.  This  Agreement  shall  immediately  terminate  in  the  event  of its
assignment,  unless an order is issued by the Securities and Exchange Commission
conditionally or  unconditionally  exempting such assignment from the provisions
of Section 15(a) of the 1940 Act, in which event this Agreement  shall remain in
full force and effect  subject to the terms and  provisions  of said  order.  In
interpreting  the provisions of this paragraph 6, the  definitions  contained in
Section  2(a) of the  1940  Act and the  applicable  rules  under  the  1940 Act
(particularly the definitions of "interested person,"  "assignment" and "vote of
a majority of the outstanding voting securities") shall be applied.

   The Adviser  agrees to furnish to the Trustees such  information on an annual
basis as may reasonably be necessary to evaluate the terms of this Agreement.

   Termination  of this  Agreement  shall not affect the right of the Adviser to
receive  payments  on any  unpaid  balance  of  the  compensation  described  in
paragraph 4 earned prior to such termination.

   7.  NON-EXCLUSIVE  SERVICES.  The  Adviser  shall,  during  the  term of this
Agreement,  be  entitled  to render  investment  advisory  services  to  others,
including,   without  limitation,   other  investment   companies  with  similar
objectives  to those of the Fund.  The  Adviser  may,  when it deems  such to be
advisable, aggregate orders for its other customers together with any securities
of the same type to be sold or  purchased  for the Fund in order to obtain  best
execution  and lower  brokerage  commissions.  In such event,  the Adviser shall
allocate the shares so purchased  or sold,  as well as the expenses  incurred in
the transaction,  in the manner it considers to be most equitable and consistent
with its fiduciary obligations to the Fund and the Adviser's other customers.

                                        4


<PAGE>


8. LIABILITY OF THE ADVISER.

   (a) The  Adviser  shall  not be  liable  for any act or  omission,  error  of
judgment or mistake of law, or for any loss  suffered by the Fund in  connection
with matters  relating to this  Agreement,  except a loss resulting from willful
misfeasance, bad faith or gross negligence of the Adviser in the performance of,
or from reckless  disregard of, its obligations and duties under this Agreement,
or except a loss resulting from breach of fiduciary duty with respect to receipt
of  compensation  for  services  (in which  case any award of  damages  shall be
limited to the period and amount set forth in Section 36(b)(3) of the 1940 Act).

   (b) A copy of the  Declaration  of  Trust  of the  Fund is on file  with  the
Secretary  of the State of  Massachusetts,  and notice is hereby given that this
Agreement is not executed on behalf of the Trustees of the Fund as  individuals,
and the  obligations of this agreement are not binding upon any of the Trustees,
officers,  shareholders  or partners of the Fund  individually,  but are binding
only upon the assets and property of the Fund.

   The Adviser agrees that no  shareholder,  Trustee,  officer or partner of the
Fund may be held  personally  liable or responsible  for any  obligations of the
Fund  arising out of this  Agreement.  With respect to  obligations  of the Fund
arising  out  of  this  Agreement,   the  Adviser  shall  look  for  payment  or
satisfaction of any claim solely to the assets and property of the Fund.

9. MISCELLANEOUS PROVISIONS.

   Notice.  Any notice under this Agreement  shall be in writing,  addressed and
delivered or mailed, postage prepaid, to the other party at such address as such
other party may designate for the receipt of such notice.

   Amendments  Hereof.  No provision of this  Agreement may be orally changed or
discharged,  but may only be modified by an instrument in writing  signed by the
Fund and the Adviser.  In addition,  no  amendment  to this  Agreement  shall be
effective  unless  approved  by (i) the  vote  of a  majority  of the  Trustees,
including a majority of the  Trustees  who are not parties to this  Agreement or
interested  persons of any such party cast in person at a meeting called for the
purpose  of voting on such  amendment,  and (ii) the vote of a  majority  of the
outstanding  voting securities of the Fund (other than an amendment which can be
effective without shareholder approval under applicable law).

   SEVERABILITY.  Each  provision of this Agreement is intended to be severable.
If any  provision of this  Agreement  shall be held illegal or made invalid by a
court decision,  statute, rule or otherwise, such illegality or invalidity shall
not affect the validity or enforceability of the remainder of this Agreement.

                                        5


<PAGE>


   HEADINGS.  The headings in this  Agreement are inserted for  convenience  and
identification only and are in no way intended to describe, interpret, define or
limit the size, extent or intent of this Agreement or any provision hereof.

   APPLICABLE  LAW. This Agreement  construed in accordance with the laws of the
State of  Colorado.  To the  extent  that the  applicable  laws of the  State of
Colorado,  or any of the provisions herein,  conflict with applicable provisions
of the 1940 Act, the latter shall control.

   IN WITNESS  WHEREOF,  the Adviser and the Fund each has caused this Agreement
to be duly executed on its behalf by an officer  thereunto duly authorized,  the
day and year first above written.

                                          INVESCO FUNDS GROUP, INC.



                                          By: /s/ William J. Galvin
                                              ------------------------
                                               William J. Galvin
                                               Senior Vice President
ATTEST:

By:  /s/ Glen A. Payne                   
     ------------------------                   
     Glen A. Payne, Secretary

                                          INVESCO GLOBAL HEALTH SCIENCES FUND



                                          By:  /s/ John Schroer 
                                               -----------------------
                                                John Schroer
                                                Vice President
ATTEST:

By:  /s/ Glen A. Payne                   
     ------------------------                   
     Glen A. Payne, Secretary



                  Amendment to Investment Advisory Agreement

This is an Amendment to the Investment Advisory Agreement (the "Agreement") made
and entered into between the INVESCO Global Health Sciences Fund, a
Massachusetts business trust (the "Fund"), and INVESCO Funds Group, Inc., a
Delaware corporation registered with the Securities and Exchange as an
investment adviser (the "Adviser"), effective as of the 1st day of November,
1998.

WHEREAS, the Fund and the Adviser desire to specify that the advisory fee to be
paid to the Adviser by the Fund under the Agreement will be computed based on
the Fund's daily net assets; and

WHEREAS, the Fund and the Adviser desire to incorporate into the advisory fee
rate set forth in the Agreement the new ninety basis point breakpoint approved
by the Fund's Board of Trustees on February 3, 1998.

NOW, THEREFORE, in consideration of the premises and mutual covenants contained
in the Agreement, it is agreed that the provisions of Section 4 of the Agreement
entitled "Compensation of the Adviser" are hereby amended to read as follows:

      COMPENSATION OF THE ADVISER. For the services to be rendered and the
      charges and expenses to be assumed by the Adviser hereunder, the Fund
      shall pay to the Adviser a monthly fee at the annual rate of 1.00% of the
      Fund's daily net assets up to $500 million, and 0.90% of the Fund's daily
      net assets on all assets of the Fund over $500 million. The fee provided
      for hereunder shall be prorated in any month in which this Agreement is
      not in effect for the entire month.

                                      


<PAGE>


IN WITNESS WHEREOF, the parties have executed this Amendment on this 1st day of
November, 1998.

INVESCO GLOBAL HEALTH SCIENCES FUND

Attest:     Glen A. Payne /s/
            Secretary

By:         Mark H. Williamson /s/
            President


INVESCO FUNDS GROUP, INC.

Attest:     Glen A. Payne /s/
            Secretary

By:         Ronald L. Grooms /s/
            Senior Vice President






                             DEFERRED FEE AGREEMENT



      THIS AGREEMENT, dated ____________, 1998, by and between ______________
("Trustee"), currently residing at ____________________________________________,
and INVESCO Global Health Sciences Fund, a Massachusetts Business Trust with
offices at 7800 East Union Avenue, Denver, Colorado (the "Trust").

                               W I T N E S S E T H

      WHEREAS, Trustee currently serves as director of the Trust and receives
fees ("Trustee's Fees") from the Trust in that capacity; and

      WHEREAS, Trustee desires that an arrangement be established with the Trust
under which he or she may defer receipt of the Trustee's Fees which may
otherwise become payable to him and which relate to services performed after the
date hereof; and

      WHEREAS, the Trust is agreeable to such an arrangement as evidenced by the
resolution of its Board of Trustees ("Board") dated October 12, 1998.

      NOW, THEREFORE, IT IS AGREED AS FOLLOWS:

      1.  Trustee irrevocably elects to defer receipt, subject to the provisions
of this Agreement, of $____________, $___________ per annum, or __________
percent (___%) of any Trustee's Fees which may otherwise become payable to him
or her after the date of this Agreement, and which relate to services performed
after the date hereof. An election to defer either a dollar amount per annum or

<PAGE>

a percentage of Trustee's Fees shall continue from year to year unless Trustee
terminates such election by written request. Any such termination shall be
effective only with respect to Trustee's Fees which become payable after the
date of termination. Trustee's Fees with respect to which Trustee shall have
elected to defer receipt (and shall not have revoked such election) as provided
above are hereinafter referred to as "Deferred Trustee's Fees."

      2.  During any calendar year for which Trustee's Fees otherwise payable to
Trustee are Deferred Trustee's Fees, the Trust shall credit the amount of such
Deferred Trustee's Fees as of the date such fees would have been paid to such
Trustee had this Agreement not been in effect to a separate memorandum account
(the "Deferred Fee Account").

      3.  The Deferred Fee Account shall be deemed invested in shares of the
Trust. The Deferred Fee Account shall be adjusted to reflect its share of any
income or gain or charged with its share of any loss arising from such deemed
investments by the Deferred Fee Account.

      4.  The Trust may, at its sole discretion, set aside assets to fund the
obligations created by this Agreement and similar agreements by other trustees
of the Trust in a Deferred Fee Account Fund and may invest assets of the
Deferred Fee Account Fund in any investment medium including, but not limited
to, shares of the Trust and any other security or investment medium in which the
assets of the Trust are permitted to be invested.

      5.  The  Trust's  obligation  to  make  payments  out of the Deferred Fee
Account shall be a general obligation of the Trust, and such payment shall be
made from the Trust's general assets and property. Trustee's relationship to the
Trust under this Agreement shall be that of a general unsecured creditor, and
neither


                                       2
<PAGE>

this Agreement nor any action taken pursuant to this Agreement shall create or
be construed to create a trust or fiduciary relationship of any kind between the
Trust and Trustee, his or her designated beneficiary or any other person, or a
security interest of any kind in any property of the Trust in favor of Trustee
or any other person. The Trust shall not be required to purchase, hold or
dispose of any investments pursuant to this Agreement; however, in order to
cover its obligations hereunder, if the Trust elects to establish a Deferred Fee
Account Fund to purchase any investments (including, without limitation, shares
of the Trust), the same shall continue for all purposes to be a part of the
general assets and property of the Trust, subject to the claims of its general
creditors, and no person other than the Trust shall by virtue of the provisions
of this Agreement have any interest in such assets other than an interest as a
general creditor. The Trust shall provide an annual statement to each Trustee
who shall have elected to defer receipt of Trustee's Fees showing such
information as is appropriate, including the aggregate amount credited or
charged to the Deferred Fee Account, as of a reasonably current date.

      6.  Payment of amounts out of the Deferred Fee Account shall be made to
Trustee as selected by Trustee below.

          Once a selection has been made, Trustee may not select a different
time or method of payment for prior amounts credited to his Deferred Fee
Account, but may select a different payment time or method for future Trustee's
Fees to be credited to the Deferred Fee Account.



                                       3
<PAGE>

          Payments shall be made to Trustee upon the happening of the
following event or events (the "payment event"), unless the Trust, in its sole
discretion, determines to make payments at another time:

            __________  termination of service as a Trustee.

            __________  attainment of age ___.

            __________  termination of service as a Trustee or attainment of 
                        age ____, whichever may first occur.

            Payments shall be made to Trustee as follows:

            __________  lump sum payment.

            __________  payment in _____ quarterly installments, each payment to
                        be equal to the value of the Deferred Fee Account
                        immediately prior to the date of payment divided by the
                        number of remaining payments.

The death of Trustee shall constitute the payment event and payments shall then 
be made as set forth in paragraph 7(b) herein.

      In the event Trustee selects installment payments, each quarterly
installment payment shall be made as of the last day of the months of January,
April, July, and October of each year, beginning with the payment month next
following the payment event. Until payments of amounts credited to the Deferred
Fee Account have been completed, the unpaid balance shall be credited with the
income and gains and charged with losses of the deemed investments in the
Deferred Fee Account Trust. The Trust in its sole discretion reserves the right
to accelerate payments of amounts in Trustee's Deferred Fee Account at any time
after the payment event. Notwithstanding the foregoing, in the event of the
liquidation, dissolution or winding up of the Trust's assets and property of its
shareholders, all unpaid amounts in the Deferred Fee Account as of the effective
date thereof shall be paid in a lump sum on such effective date. (For this


                                       4
<PAGE>

purpose, a sale, conveyance or transfer of the Trust's assets to a trust,
partnership, association or another Trust in exchange for cash, shares or other
securities, with the transfer being made subject to, or with the assumption by
the transferee of, the liabilities of the Trust, shall not be deemed a
termination of the Trust or such a distribution.)

      7.  Payment of amounts credited to the Deferred Fee Account  shall be made
to Trustee in the form of a check.  Such payment shall be made to Trustee except
that:

          a.   in the  event  that  Trustee  shall be  determined  by a court of
               competent  jurisdiction  to be  incapable  of managing his or her
               financial  affairs,  and if the Trust has  actual  notice of such
               determination,  payment  shall  be  made  to  Trustee's  personal
               representative(s); and

          b.   in the event of  Trustee's  death,  payment  shall be made to the
               last beneficiary  designated by Trustee for purposes of receiving
               such payment in such event in a written  notice  delivered to the
               President of the Trust; provided that if such beneficiary has not
               survived  Trustee,  payment  shall be made to  Trustee's  estate.
               Trustee                     hereby                     designates
               ______________________________________________________   as   the
               initial  beneficiary  for purposes of  receiving  such payment in
               such  event.   Trustee  may  from  time  to  time  designate  new
               beneficiaries and such designation  shall effectively  revoke all
               prior designations filed by Trustee.

      8.  The  Trust may  in  its  sole  discretion  accelerate the payment of
deferred amounts if such acceleration is requested by a Trustee or, after his or
her death, by his or her beneficiary or heir. Acceleration may occur only in the
event of unforeseeable financial emergency or severe hardship resulting from one


                                       5
<PAGE>

or more recent events beyond the control of Trustee or his or her beneficiary or
heir and is limited to the amount deemed reasonably necessary to satisfy the
emergency or hardship. The acceleration must be approved by the Board without
regard to the vote of the Trustee who requests the acceleration.

      9.  Amounts in the Deferred Fee Account shall not in any way be subject to
the debts or other obligations of Trustee and may not be sold, transferred,
pledged or assigned by him or her except as provided in paragraph 6(b).

      10. This Agreement shall not be construed to confer any right on the part
of Trustee to be or remain a Trustee of the Trust or to receive any, or any
particular rate of, Trustee's Fees.

      11. Interpretations of and determinations related to this Agreement made
by the Trust, including the matter of whether to establish a Deferred Fee
Account Fund, the selection of an investment medium for the assets in the Trust,
if established, and determinations of the amounts in the Deferred Fee Account,
shall be made by a committee composed of the President and the Treasurer of the
Trust and the principal investment officer of the Trust's United States-based
investment adviser (the "Committee") and, if made in good faith, shall be
conclusive and binding upon all parties; and the Trust shall not incur any
liability to Trustee for any such interpretation or determination so made or for
any other action taken by it in connection with this Agreement in good faith.
The Committee shall administer this Agreement, and shall be responsible for
administration of the Deferred Fee Account Fund, if established. All actions of
the Committee shall be considered for all purposes to be the action of the Board
unless the Board, in its capacity as such, subsequently takes a different
action. The Board may employ such persons or organizations to render advice or


                                       6
<PAGE>

perform services with respect to its responsibilities as it, in its sole
discretion, determines to be necessary and appropriate. Any actions taken by the
Board pursuant to this Section 11 shall be implemented only if approved by a
majority of those Trustees of the Trust who are not participants in a Deferred
Fee Agreement with the Trust.

      12. This Agreement contains the entire understanding and agreement between
the parties with respect to the subject matter hereof, and may not be amended,
modified or supplemented in any respect except by subsequent written agreement
entered into by all parties.

      13. This Agreement shall be binding upon, and shall inure to the benefit
of, the Trust and its successors and assigns and Trustee and his/her heirs,
executors, administrators and personal representatives.

      14. This Agreement is being entered into in, and shall be construed in
accordance with the laws of, the State of Colorado.

      15. The Trust reserves the right to terminate this Agreement at any time.
Upon such termination, all deferral elections will cease to be effective and all
contractual obligations created under this Agreement will be fixed as of the
termination date. Distribution of deferred accounts will be made at the sole
discretion of the Trust.



                                       7
<PAGE>

      IN WITNESS WHEREOF, the Trust has caused this Agreement to be executed on
its behalf by its President, and Trustee has executed this Agreement, on the
date first written above.

                                    INVESCO GLOBAL HEALTH SCIENCES FUND



                                    By:   /s/ Fred A. Deering
                                          ------------------------------------
                                          Fred A. Deering, Trustee



                                    By:   /s/ John W. McIntyre
                                          ------------------------------------
                                          John W. McIntyre, Trustee



                                    By:   /s/ Larry Soll
                                          ------------------------------------
                                          Dr. Larry Soll, Trustee







                                       8





                   DEFINED BENEFIT DEFERRED COMPENSATION PLAN
                    FOR NON-INTERESTED DIRECTORS AND TRUSTEES


      INVESCO Global Health Sciences Fund (the "Trust") has adopted this Defined
Benefit Deferred Compensation Plan ("Plan") for the benefit of those trustees of
the Trust who are not interested trustees thereof as defined in Section 2(a)(19)
of the Investment Company Act of 1940, as amended ("Independent Trustees").

      1.    ELIGIBILITY

      Each Independent Trustee who has served as such ("Eligible Service") on
the Board of Trustees of the Trust ("Board") for an aggregate of at least five
years at the time of his/her Service Termination Date (as defined in paragraph
2) will be entitled to receive benefits under the Plan. An Independent Trustee's
period of Eligible Service commences on the date of election to the Board.
Hereafter, references in this Plan to Independent Trustees shall be deemed to
include only those Trustees who have met the Eligible Service requirement for
Plan participation.

      2.    SERVICE TERMINATION AND SERVICE TERMINATION DATE

            a. SERVICE TERMINATION. Service Termination means termination of
service (other than by disability or death) of an Independent Trustee which
results from the Trustee's having reached his or her Service Termination Date.

            b. SERVICE TERMINATION DATE. An Independent Trustee's Service
Termination Date is that date upon which he or she no longer serves as a
Trustee. Normally, an Independent Trustee's Service Termination Date will be the
last day of the calendar quarter in which such Trustee's seventy-second birthday
occurs. A majority of the Board may annually extend a Trustee's normal Service
Termination Date for a maximum period of three years, through the date not later
than the last day of the calendar quarter in which such Trustee's seventy-fifth
birthday occurs.

      As used in this Plan unless otherwise stipulated, Service Termination Date
shall mean the date upon which the Independent Trustee no longer serves as a
Trustee.

      3.    DEFINED PAYMENTS AND BENEFIT

            a. PAYMENTS. If an Independent Trustee's Service Termination Date
occurs on a date not later than the last day of the calendar quarter in which
such Trustee's seventy-fourth birthday occurs, the Independent Trustee will
receive four quarterly payments during the first twelve months subsequent to his
or her Service Termination Date (the "First Year Retirement Payments"), with
each payment to be equal to 25 percent of the sum of the annual basic retainer
and annualized quarterly Board meeting fees payable by the Trust to the


<PAGE>

Independent Trustee on his or her Service Termination Date (excluding any fees
relating to attending or chairing committee meetings or other fees payable to an
Independent Trustee).

            b. BENEFIT. Commencing with the first anniversary of the Service
Termination Date of any Independent Trustee who has received the First Year
Retirement Payments, and commencing as of the Service Termination Date of an
Independent Trustee whose Service Termination Date is subsequent to the date of
the last day of the calendar quarter in which such Trustee's seventy-fourth
birthday occurred, the Independent Trustee will receive, for the remainder of
his or her life, a benefit (the "Benefit"), payable quarterly, with each
quarterly payment to be equal to 12.50 percent of the sum of the annual basic
retainer and annualized quarterly Board meeting fees payable by the Trust to the
Independent Trustee on his or her Service Termination Date (excluding any fees
relating to attending or chairing committee meetings or other fees payable to an
Independent Trustee).

      Example: As of July 1, 1998, the annual Benefit would be $_______ (annual
basic retainer of $______, plus annualized quarterly Board meeting fees of
$______ times 12.50 percent of the total each quarter: $_____ + $_______ =
$_______ x .125 = $______ x 4 = $______). The annual Benefit may increase or
decrease in the future in accordance with changes in the Independent Trustees'
annual basic retainer and/or Board meeting fees.

            c. DEATH PROVISIONS. If an Independent Trustee's service as a
Trustee is terminated because of his or her death subsequent to the last day of
the calendar quarter in which such Trustee's seventy-second birthday occurred
and prior to the last day of the calendar quarter in which such Trustee's
seventy-fourth birthday occurs, the designated beneficiary of the Independent
Trustee shall receive the First Year Retirement Payments and shall, commencing
with the quarter following the quarter in which the last First Year Retirement
Payment is made, receive the Benefit for a period of ten years, with quarterly
payments to be made to the designated beneficiary.

      If an Independent Trustee's service as a Trustee is terminated because of
his or her death prior to the last day of the calendar quarter in which such
Trustee's seventy-second birthday occurs or subsequent to the last day of the
calendar quarter in which such Trustee's seventy-fourth birthday occurred, the
designated beneficiary of the Independent Trustee shall receive the Benefit for
a period of ten years, with quarterly payments to be made to the designated
beneficiary commencing in the first quarter following the Trustee's death.

            d. DISABILITY PROVISIONS. If an Independent Trustee's service as a
Trustee is terminated because of his or her disability subsequent to the last
day of the calendar quarter in which such Trustee's seventy-second birthday
occurred and prior to the last day of the calendar quarter in which such
Trustee's seventy-fourth birthday occurs, the Independent Trustee shall receive
the First Year Retirement Payments and shall, commencing with the quarter
following the quarter in which the last First Year Retirement Payment is made,
receive the Benefit for the remainder of his or her life, with quarterly
payments to be made to the disabled Independent Trustee. If the disabled
Independent Trustee should die before the First Year Retirement Payments are
completed and before forty quarterly Benefit payments are made, such payments



                                       2
<PAGE>

will continue to be made to the Independent Trustee's designated beneficiary
until the aggregate of the First Year Retirement Payments and forty quarterly
Benefit payments have been made to the disabled Independent Trustee and the
Trustee's designated beneficiary.

      If an Independent Trustee's service as a Trustee is terminated because of
his or her disability prior to the last day of the calendar quarter in which
such Trustee's seventy-second birthday occurs or subsequent to the last day of
the calendar quarter in which such Trustee's seventy-fourth birthday occurred,
the Independent Trustee shall receive the Benefit for the remainder of his or
her life, with quarterly payments to be made to the disabled Independent Trustee
commencing in the first quarter following the Trustee's termination for
disability. If the disabled Independent Trustee should die before forty
quarterly payments are made, payments will continue to be made to the
Independent Trustee's designated beneficiary until the aggregate of forty
quarterly payments has been made to the disabled Independent Trustee and the
Trustee's designated beneficiary.

            e. DEATH OF INDEPENDENT TRUSTEE AND BENEFICIARY. If, subsequent to
the death of the Independent Trustee, his or her designated beneficiary should
die before the First Year Retirement Payments and/or a total of forty quarterly
Benefit payments are made, the remaining value of the Independent Trustee's
First Year Retirement Payments and/or Benefit (which Benefit shall in no event
exceed the value of forty quarterly payments minus the number of payments made)
shall be determined as of the date of the death of the Independent Trustee's
designated beneficiary and shall be paid to the estate of the designated
beneficiary in one lump sum or in periodic payments, with the determinations
with respect to the value of the First Year Retirement Payments and/or Benefit
and the method and frequency of payment to be made by the Committee (as defined
in paragraph 8.a.) in its sole discretion.

      4.    DESIGNATED BENEFICIARY

      The beneficiary referred to in paragraph 3 may be designated or changed by
the Independent Trustee without the consent of any prior beneficiary on a form
provided by the Committee (as defined in paragraph 8.a.) and delivered to the
Committee (or its designee as described on the form) before the Independent
Trustee's death. If no such beneficiary shall have been designated, or if no
designated beneficiary shall survive the Independent Trustee, the value or
remaining value of the Independent Trustee's First Year Retirement Payments
and/or Benefit (which Benefit shall in no event exceed the value of forty
quarterly payments minus the number of payments made) shall be determined as of
the date of the death of the Independent Trustee by the Committee and shall be
paid as promptly as possible in one lump sum to the Independent Trustee's
estate.

      5.    DISABILITY

      An Independent Trustee shall be deemed to have become disabled for the
purposes of paragraph 3 if the Committee shall find on the basis of medical
evidence satisfactory to it that the Independent Trustee is disabled, mentally
or physically, as a result of an accident or illness, so as to be prevented from
performing each of the duties which are incumbent upon an Independent Trustee in
fulfilling his or her responsibilities as such.



                                       3
<PAGE>

      6.    TIME OF PAYMENT

      The First Year Retirement Payments and/or the Benefit for each year will
be paid in quarterly installments that are as nearly equal as possible.

      7.    PAYMENT OF FIRST YEAR RETIREMENT PAYMENTS AND/OR BENEFIT: ALLOCATION
            OF COSTS

      The Trust is responsible for the payment of the amount of the First Year
Retirement Payments and/or Benefit applicable to the Trust, as well as its
proportionate share of all expenses of administration of the Plan, including
without limitation all accounting and legal fees and expenses and fees and
expenses of any Actuary. The obligations of the Trust to pay such First Year
Retirement Payments and/or Benefit and expenses will not be secured or funded in
any manner, and such obligations will not have any preference over the lawful
claims of the Trust's creditors and shareholders.

      8.    ADMINISTRATION

            a. THE COMMITTEE. Any question involving entitlement to payments
under or the administration of the Plan will be referred to a four-person
committee (the "Committee") composed of three Independent Trustees designated by
all of the Independent Trustees of the Trust and one Trustee of the Trust who is
not an Independent Trustee, designated by the non-Independent Trustees. Except
as otherwise provided herein, the Committee will make all interpretations and
determinations necessary or desirable for the Plan's administration, and such
interpretations and determinations will be final and conclusive. Committee
members will be elected annually.

            b. POWERS OF THE COMMITTEE. The Committee will represent and act on
behalf of the Trust in respect of the Plan and, subject to the other provisions
of the Plan, the Committee may adopt, amend or repeal bylaws or other
regulations relating to the administration of the Plan, the conduct of the
Committee's affairs, its rights or powers, or the rights or powers of its
members. The Committee will report to the Independent Trustees and to the Board
from time to time on its activities in respect of the Plan. The Committee or
persons designated by it will cause such records to be kept as may be necessary
for the administration of the Plan.

      9.    MISCELLANEOUS PROVISIONS

            a. RIGHTS NOT ASSIGNABLE. Other than as is specifically provided in
paragraph 3, the right to receive any payment under the Plan is not transferable
or assignable, and nothing in the Plan shall create any benefit, cause of
action, right of sale, transfer, assignment, pledge, encumbrance, or other such
right in any heirs or the estate of any Independent Trustee.

            b. AMENDMENT, ETC. The Committee, with the concurrence of the Board,
may at any time amend or terminate the Plan or waive any provision of the Plan;
provided, however, that subject to the limitations imposed by paragraph 7, no
amendment, termination or waiver will impair the rights of an Independent
Trustee to receive the payments which would have been made to such Independent
Trustee had there been no such amendment, termination, or waiver.



                                       4
<PAGE>

            c. NO RIGHT TO REELECTION. Nothing in the Plan will create any
obligation on the part of the Board to nominate any Independent Trustee for
reelection.

            d. CONSULTING. Subsequent to his/her Service Termination Date, an
Independent Trustee may render such services for any Trust, for such
compensation, as may be agreed upon from time to time by such Independent
Trustee and the Board. 

            e. EFFECTIVENESS. The Plan will be effective for all Independent
Trustees who have Service Termination Dates occurring on and after October 1,
1998. Periods of Eligible Service shall include periods commencing prior and
subsequent to such date. Upon its adoption by the Board, the Plan will become
effective on the date when the Committee determines that any regulatory approval
or advice that may be necessary or appropriate in connection with the Plan has
been obtained.




Adopted October 12, 1998


                                       5


                               CUSTODIAN CONTRACT
                                     Between
                         THE GLOBAL HEALTH SCIENCES FUND
                                       and
                       STATE STREET BANK AND TRUST COMPANY


<PAGE>


                                TABLE OF CONTENTS
                                -----------------
                                                                      PAGE
                                                                      ----
1.    Employment of Custodian and Property to be
      Held By It....................................................... 1

2.    Duties of the Custodian with Respect to Property of 
      the Fund Held by the
      Custodian in the United States................................... 2

      2.1   Holding Securities......................................... 2
      2.2   Delivery of Securities..................................... 3
      2.3   Registration of Securities................................. 7
      2.4   Bank Accounts.............................................. 8
      2.5   Availability of Federal Funds.............................. 9
      2.6   Collection of Income ...................................... 9
      2.7   Payment of Fund Monies..................................... 10
      2.8   Liability for Payment in Advance of
            Receipt of Securities Purchased............................ 13
      2.9   Appointment of Agents...................................... 13
      2.10  Deposit of Securities in Securities System................. 14
      2.10A Fund Assets Held in the Custodian's Direct
            Paper System............................................... 17
      2.11  Segregated Account......................................... 18
      2.12  Ownership Certificates for Tax Purposes.................... 20
      2.13  Proxies.................................................... 20
      2.14  Communication Relating to Fund
            Portfolio Securities....................................... 20
      2.15  Reports to Fund by Independent Public
            Accountants................................................ 21

3.    Duties of the Custodian with Respect to Property of 
      the Fund Held Outside of the United States....................... 22

      3.1  Appointment of Foreign Sub-custodians....................... 22
      3.2  Assets to be Held........................................... 22
      3.3  Foreign Securities Depositories............................. 23
      3.4  Segregation of Securities................................... 23
      3.5  Agreements with Foreign Banking Institutions................ 23
      3.6  Access of Independent Accountants of the Fund............... 24
      3.7  Reports by Custodian........................................ 24
      3.8  Transactions in Foreign Custody Account..................... 25
      3.9  Liability of Foreign Sub-custodians......................... 26
      3.10  Liability of Custodian..................................... 26
      3.11  Reimbursement for Advances................................. 27
      3.12  Monitoring Responsibilities................................ 28
      3.13  Branches of U.S. Banks..................................... 29
      3.14  Tax Law.................................................... 29

4.    Payments for Repurchases or Redemptions and Sales
      of Shares of the Fund............................................ 30

5.    Proper Instructions.............................................. 31

6.    Actions Permitted Without Express Authority...................... 32

7.    Evidence of Authority............................................ 32

<PAGE>

8.    Duties of Custodian with Respect to the Books of 
      Account and Calculations of Net Asset Value and
      Net Income....................................................... 33

9.    Records.......................................................... 33

10.   Opinion of Fund's Independent Accountant......................... 34

11.   Compensation of Custodian........................................ 34

12.   Responsibility of Custodian...................................... 34

13.   Effective Period, Termination and Amendment...................... 36

14.   Successor Custodian.............................................. 38

15.   Interpretive and Additional Provisions........................... 39

16.   Massachusetts Law to Apply....................................... 40

17.   Limitations of Liability of the Trustees and
      Shareholders..................................................... 40

18.   Prior Contracts.................................................. 40




<PAGE>



                               CUSTODIAN CONTRACT
                               ------------------

          This Contract between The Global Health Sciences Fund, a business
trust organized and existing under the laws of Massachusetts, having its
principal place of business at 7800 E. Union Avenue, Denver, Colorado, 80237,
hereinafter called the "Fund", and State Street Bank and Trust Company, a
Massachusetts trust company, having its principal place of business at 225
Franklin Street, Boston, Massachusetts, 02110, hereinafter called the
"Custodian",

          WITNESSETH:  That   in  consideration  of  the  mutual  covenants  and
agreements hereinafter contained, the parties hereto agree as follows:

1.        EMPLOYMENT OF CUSTODIAN AND PROPERTY TO BE HELD BY IT. The Fund hereby
employs the Custodian as the custodian of its assets, including securities it
desires to be held in places within the United States ("domestic securities")
and securities it desires to be held outside the United States ("foreign
securities") pursuant to the provisions of the Declaration of Trust. The Fund
agrees to deliver to the Custodian all securities and cash owned by it, and all
payments of income, payments of principal or capital distributions received by
it with respect to all securities owned by the Fund from time to time, and the
cash consideration received by it for such new or treasury shares of beneficial
interest ("Shares") of the Fund as may be issued or sold from time to time. The
Custodian shall not be responsible for any property of the Fund held or received
by the Fund and not delivered to the Custodian.
<PAGE>

          Upon receipt of "Proper Instructions" (within the meaning of Article
5), the Custodian shall from time to time employ one or more sub-custodians
located in the United States, but only in accordance with an applicable vote by
the Board of Trustees of the Fund, and provided that the Custodian shall have no
more or less responsibility or liability to the Fund on account of any actions
or omissions of any sub-custodian so employed than any such sub-custodian has to
the Custodian. The Custodian may employ as sub-custodians for the Fund's
securities and other assets the foreign banking institutions and foreign
securities depositories designated in Schedule "A" hereto but only in accordance
with the provisions of Article 3.

2.        DUTIES OF THE CUSTODIAN WITH RESPECT TO PROPERTY OF THE FUND HELD BY
THE CUSTODIAN IN THE UNITED STATES

2.1       HOLDING SECURITIES. The Custodian shall hold and physically segregate
          for the account of the Fund all noncash property, to be held by it in
          the United States, including all domestic securities owned by the
          Fund, other than (a) securities which are maintained pursuant to
          Section 2.10 in a clearing agency which acts as a securities
          depository or in a book-entry system authorized by the U.S. Department
          of the Treasury, collectively referred to herein as "Securities
          System" and (b) commercial paper of an issuer for which State Street
          Bank and Trust Company acts as issuing and paying agent ("Direct
          Paper") which is deposited and/or maintained in the Direct Paper
          System of the Custodian pursuant to Section 2.10A.


                                       - 2 -
<PAGE>

2.2       DELIVERY OF SECURITIES. The Custodian shall release and deliver
          domestic securities owned by the Fund held by the Custodian or in a
          Securities System account of the Custodian or in the Custodian's
          Direct Paper book-entry system account ("Direct Paper System Account")
          only upon receipt of Proper Instructions, which may be continuing
          instructions when deemed appropriate by the parties, and only in the
          following cases:

          1)   Upon sale of such securities for the account of the Fund and 
               receipt of payment therefor;

          2)   Upon the receipt of payment in connection with any repurchase
               agreement related to such securities entered into by the Fund;

          3)   In the case of a sale effected through a Securities System, in
               accordance with the provisions of Section 2.10 hereof;

          4)   To the depository agent in connection with tender or other
               similar offers for portfolio securities of the Fund;

          5)   To the issuer thereof or its agent when such securities are
               called, redeemed, retired or otherwise become payable; provided
               that, in any such case, the cash or other consideration is to be
               delivered to the Custodian;

          6)   To the issuer thereof, or its agent, for transfer into the name 
               of the Fund or into the name of any nominee or nominees of the


                                        - 3 -
<PAGE>

               Custodian or into the name or nominee name of any agent appointed
               pursuant to Section 2.9 or into the name or nominee name of any
               sub-custodian appointed pursuant to Article 1; or for exchange
               for a different number of bonds, certificates or other evidence
               representing the same aggregate face amount or number of units;
               PROVIDED that, in any such case, the new securities are to be
               delivered to the Custodian;

          7)   Upon the sale of such securities for the account of the Fund, to
               the broker or its clearing agent, against a receipt, for
               examination in accordance with "street delivery" custom; provided
               that in any such case, the Custodian shall have no responsibility
               or liability for any loss arising from the delivery of such
               securities prior to receiving payment for such securities except
               as may arise from the Custodian's own negligence or willful
               misconduct;

          8)   For exchange or conversion pursuant to any plan of merger,
               consolidation, recapitalization, reorganization or readjustment


                                       - 4 -
<PAGE>

               of the securities of the issuer of such securities, or pursuant
               to provisions for conversion contained in such securities, or
               pursuant to any deposit agreement; provided that, in any such
               case, the new securities and cash, if any, are to be delivered to
               the Custodian;

          9)   In the case of warrants, rights or similar securities, the
               surrender thereof in the exercise of such warrants, rights or
               similar securities or the surrender of interim receipts or
               temporary securities for definitive securities; provided that, in
               any such case, the new securities and cash, if any, are to be
               delivered to the Custodian;

          10)  For delivery in connection with any loans of securities made by
               the Fund, BUT ONLY against receipt of adequate collateral as
               agreed upon from time to time by the Custodian and the Fund,
               which may be in the form of cash or obligations issued by the
               United States government, its agencies or instrumentalities,
               except that in connection with any loans for which collateral is
               to be credited to the Custodian's account in the book-entry
               system authorized by the U.S. Department of the Treasury, the
               Custodian will not be held liable or responsible for the delivery


                                     - 5 -
<PAGE>

               of securities owned by the Fund prior to the receipt of such
               collateral;
     
          11)  For delivery as security in connection with any borrowings by the
               Fund requiring a pledge of assets by the Fund, BUT ONLY against
               receipt of amounts borrowed;

          12)  For delivery in accordance with the provisions of any agreement
               among the Fund, the Custodian and a broker-dealer registered
               under the Securities Exchange Act of 1934 (the "Exchange Act")
               and a member of The National Association of Securities Dealers,
               Inc. ("NASD"), relating to compliance with the rules of The
               Options Clearing Corporation and of any registered national
               securities exchange, or of any similar organization or
               organizations, regarding escrow or other arrangements in
               connection with transactions by the Fund;

          13)  For delivery in accordance with the provisions of any agreement
               among the Fund, the Custodian, and a Futures Commission Merchant
               registered under the Commodity Exchange Act, relating to
               compliance with the rules of the Commodity Futures Trading
               Commission and/or any Contract Market, or any similar


                                      - 6 -
<PAGE>

               organization or organizations, regarding account deposits in
               connection with transactions by the Fund;

          14)  Upon receipt of instructions from the transfer agent ("Transfer
               Agent") for the Fund, for delivery to such Transfer Agent or to
               the holders of shares in connection with distributions in kind,
               as may be described from time to time in the Fund's currently
               effective prospectus and statement of additional information
               ("prospectus"), in satisfaction of requests by holders of Shares
               for repurchase or redemption; and

          15)  For any other proper corporate purpose, BUT ONLY upon receipt of,
               in addition to Proper Instructions, a certified copy of a
               resolution of the Board of Trustees or of the Executive Committee
               signed by an officer of the Fund and certified by the Secretary
               or an Assistant Secretary, specifying the securities to be
               delivered, setting forth the purpose for which such delivery is
               to be made, declaring such purpose to be a proper corporate
               purpose, and naming the person or persons to whom delivery of
               such securities shall be made. 

2.3       REGISTRATION OF SECURITIES. Domestic securities held by the Custodian
          (other than bearer securities) shall be registered in the name of the


                                      - 7 -
<PAGE>

          Fund or in the name of any nominee of the Fund or of any nominee of
          the Custodian which nominee shall be assigned exclusively to the Fund,
          UNLESS the Fund has authorized in writing the appointment of a nominee
          to be used in common with other registered investment companies having
          the same investment adviser as the Fund, or in the name or nominee
          name of any agent appointed pursuant to Section 2.9 or in the name or
          nominee name of any sub-custodian appointed pursuant to Article 1. All
          securities accepted by the Custodian on behalf of the Fund under the
          terms of this Contract shall be in "street name" or other good
          delivery form. If, however, the Fund directs the Custodian to maintain
          securities in "street name", the Custodian shall utilize its best
          efforts only to timely collect income due the Fund on such securities
          and to notify the Fund on a best efforts basis only of relevant
          corporate actions including, without limitation, pendency of calls,
          maturities, tender or exchange offers.

2.4       BANK ACCOUNTS.  The Custodian shall open and maintain a separate bank
          account or accounts in the United States in the name of the Fund,
          subject only to draft or order by the Custodian acting pursuant to the
          terms of this contract, and shall hold in such account or accounts,
          subject to the provisions hereof, all cash received by it from or for
          the account of the Fund, other than cash maintained by the Fund in a


                                     - 8 -
<PAGE>

          bank account established and used in accordance with Rule 17f-3 under
          the Investment Company Act of 1940. Funds held by the Custodian for
          the Fund may be deposited by it to its credit as Custodian in the
          Banking Department of the Custodian or in such other banks or trust
          companies as it may in its discretion deem necessary or desirable;
          PROVIDED however, that every such bank or trust company shall be
          qualified to act as a custodian under the Investment Company Act of
          1940 and that each such bank or trust company and the funds to be
          deposited with each such bank or trust company shall be approved by
          vote of a majority of the Board of Trustees of the Fund. Such funds
          shall be deposited by the Custodian in its capacity as Custodian and
          shall be withdrawable by the Custodian only in that capacity.

2.5       AVAILABILITY OF FEDERAL FUNDS.  Upon mutual agreement between the Fund
          and the Custodian, the Custodian shall, upon the receipt of Proper
          Instructions, make federal funds available to the Fund as of specified
          times agreed upon from time to time by the Fund and the Custodian in
          the amount of checks received in payment for Shares of the Fund which
          are deposited into the Fund's account. 

2.6       COLLECTION OF INCOME. Subject to the provisions of Section 2.3, the
          Custodian shall collect on a timely basis all income and other
          payments with respect to United States registered securities held
          hereunder to which the Fund shall be entitled either by law or
          pursuant to custom in the securities business, and shall collect on a
   



                                     - 9 -
<PAGE>
          timely basis all income and other payments with respect to United
          States bearer securities if, on the date of payment by the issuer,
          such securities are held by the Custodian or its agent thereof and
          shall credit such income, as collected, to the Fund's custodian
          account. Without limiting the generality of the foregoing, the
          Custodian shall detach and present for payment all coupons and other
          income items requiring presentation as and when they become due and
          shall collect interest when due on securities held hereunder. Income
          due the Fund on United States securities loaned pursuant to the
          provisions of Section 2.2 (10) shall be the responsibility of the
          Fund. The Custodian will have no duty or responsibility in connection
          therewith, other than to provide the Fund with such information or
          data as may be necessary to assist the Fund in arranging for the
          timely delivery to the Custodian of the income to which the Fund is
          properly entitled. 


2.7       PAYMENT OF FUND MONIES. Upon receipt of Proper Instructions, which may
          be continuing instructions when deemed appropriate by the parties, the
          Custodian shall pay out monies of the Fund in the following cases
          only:
               1)   Upon the purchase of domestic securities, options, futures
                    contracts or options on futures contracts for the account of
                    the fund but only (a) against the delivery of such
                    securities, or evidence of title to such options, futures



                                     - 10 -
<PAGE>

                    Contracts or options on futures contracts, to the custodian
                    (or any bank, banking firm or trust company doing business
                    in the united states or abroad which is qualified under the
                    investment company act of 1940, as amended, to act as a
                    custodian and has been designated by the custodian as its
                    agent for this purpose) registered in the name of the fund
                    or in the name of a nominee of the custodian referred to in
                    section 2.3 Hereof or in proper form for transfer; (b) in
                    the case of a purchase effected through a securities system,
                    in accordance with the conditions set forth in section 2.10
                    Hereof; (c) in the case of a purchase involving the direct
                    paper system, in accordance with the conditions set forth in
                    section 2.10A; (d) in the case of repurchase agreements
                    entered into between the fund and the custodian, or another
                    bank, or a broker-dealer which is a member of nasd, (i)
                    against delivery of the securities either in certificate
                    form or through an entry crediting the custodian's account
                    at the federal reserve bank with such securities or (ii)
                    against delivery of the receipt evidencing purchase by the
                    fund of securities owned by the custodian along with written


                                     - 11 -
<PAGE>

                    evidence of the agreement by the Custodian to repurchase
                    such securities from the Fund or (e) for transfer to a time
                    deposit account of the Fund in any bank, whether domestic or
                    foreign; such transfer may be effected prior to receipt of a
                    confirmation from a broker and/or the applicable bank
                    pursuant to Proper Instructions from the Fund as defined in
                    Article 5;

               2)   In connection with conversion, exchange or surrender of
                    securities owned by the Fund as set forth in Section 2.2
                    hereof; 

               3)   For the redemption or repurchase of Shares issued by
                    the Fund as set forth in Article 4 hereof; 

               4)   For the payment of any expense or liability incurred by the
                    Fund, including but not limited to the following payments
                    for the account of the fund: interest, taxes, management,
                    accounting, transfer agent and legal fees, and operating
                    expenses of the fund whether or not such expenses are to be
                    in whole or part capitalized or treated as deferred
                    expenses; 

               5)   For the payment of any dividends declared pursuant
                    to the governing documents of the Fund;




                                     - 12 -
<PAGE>

               6)   For payment of the amount of dividends received in respect
                    of securities sold short;

               7)   For any other proper purpose, BUT ONLY upon receipt of, in
                    addition to Proper Instructions, a certified copy of a
                    resolution of the Board of Trustees or of the Executive
                    Committee of the Fund signed by an officer of the Fund and
                    certified by its Secretary or an Assistant Secretary,
                    specifying the amount of such payment, setting forth the
                    purpose for which such payment is to be made, declaring such
                    purpose to be a proper purpose, and naming the person or
                    persons to whom such payment is to be made. 

2.8       LIABILITY FOR PAYMENT IN ADVANCE OF RECEIPT OF SECURITIES PURCHASED.
          Except as specifically stated otherwise in this Contract, in any and
          every case where payment for purchase of domestic securities for the
          account of the Fund is made by the Custodian in advance of receipt of
          the securities purchased in the absence of specific written
          instructions from the Fund to so pay in advance, the Custodian shall
          be absolutely liable to the Fund for such securities to the same
          extent as if the securities had been received by the Custodian.

2.9       APPOINTMENT OF AGENTS. The Custodian may at any time or times in its
          discretion appoint (and may at any time remove) any other bank or
          trust company which is itself



                                     - 13 -
<PAGE>

          qualified under the Investment Company Act of 1940, as amended, to act
          as a custodian, as its agent to carry out such of the provisions of
          this Article 2 as the Custodian may from time to time direct;
          PROVIDED, however, that the appointment of any agent shall not relieve
          the Custodian of its responsibilities or liabilities hereunder.


2.10      DEPOSIT OF SECURITIES IN SECURITIES SYSTEMS.
          The Custodian may deposit and/or maintain domestic securities owned by
          the Fund in a clearing agency registered with the Securities and
          Exchange Commission under section 17A of the Securities Exchange Act
          of 1934, which acts as a securities depository, or in the book-entry
          system authorized by the U.S. Department of the Treasury and certain
          federal agencies, collectively referred to herein as "Securities
          System" in accordance with applicable Federal Reserve Board and
          Securities and Exchange Commission rules and regulations, if any, and
          subject to the following provisions:

               1)   The Custodian may keep domestic securities of the Fund in a
                    Securities System provided that such securities are
                    represented in an account ("Account") of the Custodian in
                    the Securities System which shall not include any assets of
                    the Custodian other than assets held as a fiduciary,
                    custodian or otherwise for customers;



                                     - 14 -
<PAGE>

               2)   The records of the Custodian with respect to domestic
                    securities of the Fund which are maintained in a Securities
                    System shall identify by book-entry those securities
                    belonging to the Fund;

               3)   The Custodian shall pay for domestic securities purchased
                    for the account of the Fund upon (i) receipt of advice from
                    the Securities System that such securities have been
                    transferred to the Account, and (ii) the making of an entry
                    on the records of the Custodian to reflect such payment and
                    transfer for the account of the Fund. The Custodian shall
                    transfer domestic securities sold for the account of the
                    Fund upon (i) receipt of advice from the Securities System
                    that payment for such securities has been transferred to the
                    Account, and (ii) the making of an entry on the records of
                    the Custodian to reflect such transfer and payment for the
                    account of the Fund. Copies of all advices from the
                    Securities System of transfers of domestic securities for
                    the account of the Fund shall identify the Fund, be
                    maintained for the Fund by the Custodian and be provided to
                    the Fund at its request. Upon request, the Custodian shall
               

                                     - 15 -
<PAGE>

                    furnish the Fund confirmation of each transfer to or from
                    the account of the Fund in the form of a written advice or
                    notice and shall furnish to the Fund copies of daily
                    transaction sheets reflecting each day's transactions in the
                    Securities System for the account of the Fund.

               4)   The Custodian shall provide the Fund with any report
                    obtained by the Custodian on the Securities System's
                    accounting system, internal accounting control and
                    procedures for safeguarding domestic securities deposited in
                    the Securities System;
          
               5)   The Custodian shall have received the initial or annual
                    certificate, as the case may be, required by Article 13
                    hereof;
               
               6)   Anything to the contrary in this Contract notwithstanding,
                    the Custodian shall be liable to the Fund for any loss or
                    damage to the Fund resulting from use of the Securities
                    System by reason of any negligence, misfeasance or
                    misconduct of the Custodian or any of its agents or of any
                    of its or their employees or from failure of the Custodian
                    or any such agent to enforce effectively such rights as it
                    may have against the Securities System; at the election of
                    the Fund, it shall be entitled to be subrogated to the


                                     - 16 -
<PAGE>

                    rights of the Custodian with respect to any claim against
                    the Securities System or any other person which the
                    Custodian may have as a consequence of any such loss or
                    damage if and to the extent that the Fund has not been made
                    whole for any such loss or damage.

2.10A     FUND ASSETS HELD IN THE CUSTODIAN'S DIRECT PAPER SYSTEM
          The Custodian may deposit and/or maintain securities owned by the Fund
          in the Direct Paper System of the Custodian subject to the following
          provisions:

               1)   No transaction relating to securities in the Direct Paper
                    System will be effected in the absence of Proper
                    Instructions;

               2)   The Custodian may keep securities of the Fund in the Direct
                    Paper System only if such securities are represented in an
                    account ("Account") of the Custodian in the Direct Paper
                    System which shall not include any assets of the Custodian
                    other than assets held as a fiduciary, custodian or
                    otherwise for customers; 

               3)   The records of the Custodian with respect to securities of
                    the Fund which are maintained in the Direct Paper System
                    shall identify by book-entry those securities belonging to
                    the Fund;




                                     - 17 -
<PAGE>


               4)   The Custodian shall pay for securities purchased for the
                    account of the Fund upon the making of an entry on the
                    records of the Custodian to reflect such payment and
                    transfer of securities to the account of the Fund. The
                    Custodian shall transfer securities sold for the account of
                    the Fund upon the making of an entry on the records of the
                    Custodian to reflect such transfer and receipt of payment
                    for the account of the Fund; 

               5)   The Custodian shall furnish the Fund confirmation of each
                    transfer to or from the account of the Fund, in the form of
                    a written advice or notice, of Direct Paper on the next
                    business day following such transfer and shall furnish to
                    the Fund copies of daily transaction sheets reflecting each
                    day's transaction in the Securities System for the account
                    of the Fund; 

               6)   The Custodian shall provide the Fund with any report on its
                    system of internal accounting control as the Fund may
                    reasonably request from time to time;

2.11      SEGREGATED ACCOUNT. The Custodian shall upon receipt of Proper
          Instructions establish and maintain a segregated account or accounts
          for and on behalf of the Fund, into which account or accounts may be


                                     - 18 -
<PAGE>

          transferred cash and/or securities, including securities maintained in
          an account by the Custodian pursuant to Section 2.10 hereof, (i) in
          accordance with the provisions of any agreement among the Fund, the
          Custodian and a broker-dealer registered under the Exchange Act and a
          member of the NASD (or any futures commission merchant registered
          under the Commodity Exchange Act), relating to compliance with the
          rules of The Options Clearing Corporation and of any registered
          national securities exchange (or the Commodity Futures Trading
          Commission or any registered contract market), or of any similar
          organization or organizations, regarding escrow or other arrangements
          in connection with transactions by the Fund, (ii) for purposes of
          segregating cash or government securities in connection with options
          purchased, sold or written by the Fund or commodity futures contracts
          or options thereon purchased or sold by the Fund, (iii) for the
          purposes of compliance by the Fund with the procedures required by
          Investment Company Act Release No. 10666, or any subsequent release or
          releases of the Securities and Exchange Commission relating to the
          maintenance of segregated accounts by registered investment companies
          and (iv) for other proper corporate purposes, BUT ONLY, in the case of
          clause (iv), upon receipt of, in addition to Proper Instructions, a
          certified copy of a resolution of the Board of Trustees or of the
          Executive Committee signed by an officer of the Fund and certified by

                                     - 19 -
<PAGE>


          the Secretary or an Assistant Secretary, setting forth the purpose or
          purposes of such segregated account and declaring such purposes to be
          proper corporate purposes. 

2.12      OWNERSHIP CERTIFICATES FOR TAX PURPOSES. The Custodian shall execute
          ownership and other certificates and affidavits for all federal and
          state tax purposes in connection with receipt of income or other
          payments with respect to domestic securities of the Fund held by it
          and in connection with transfers of such securities. 

2.13      PROXIES. The Custodian shall, with respect to the domestic securities
          held hereunder, cause to be promptly executed by the registered holder
          of such securities, if the securities are registered otherwise than in
          the name of the Fund or a nominee of the Fund, all proxies, without
          indication of the manner in which such proxies are to be voted, and
          shall promptly deliver to the Fund such proxies, all proxy soliciting
          materials and all notices relating to such securities. 

2.14      COMMUNICATIONS RELATING TO FUND PORTFOLIO SECURITIES Subject to
          the provisions of Section 2.3, the Custodian shall transmit promptly
          to the Fund all written information (including, without limitation,
          pendency of calls and maturities of domestic securities and
          expirations of rights in connection therewith and notices of exercise
          of call and put options written by the Fund and the maturity of
          futures contracts purchased or sold by the Fund) received by the


                                     - 20 -
<PAGE>

          Custodian from issuers of the domestic securities being held for the
          Fund. With respect to tender or exchange offers, the Custodian shall
          transmit promptly to the Fund all written information received by the
          Custodian from issuers of the domestic securities whose tender or
          exchange is sought and from the party (or his agents) making the
          tender or exchange offer. If the Fund desires to take action with
          respect to any tender offer, exchange offer or any other similar
          transaction, the Fund shall notify the Custodian at least three
          business days prior to the date on which the Custodian is to take such
          action.


2.15      REPORTS TO FUND BY INDEPENDENT PUBLIC ACCOUNTANTS
          The Custodian shall provide the Fund, at such times as the Fund may
          reasonably require, with reports by independent public accountants on
          the accounting system, internal accounting control and procedures for
          safeguarding securities, futures contracts and options on futures
          contracts, including domestic securities deposited and/or maintained
          in a Securities System, relating to the services provided by the
          Custodian under this Contract; such reports shall be of sufficient
          scope and in sufficient detail, as may reasonably be required by the
          Fund to provide reasonable assurance that any material inadequacies
          would be disclosed by such examination, and, if there are no such
          inadequacies, the reports shall so state.



                                     - 21 -
<PAGE>

3.        DUTIES OF THE CUSTODIAN WITH RESPECT TO PROPERTY OF THE
FUND HELD OUTSIDE OF THE UNITED STATES

3.1       APPOINTMENT OF FOREIGN SUB-CUSTODIANS

          The Fund hereby authorizes and instructs the Custodian to employ as
          sub-custodians for the Fund's securities and other assets maintained
          outside the United States the foreign banking institutions and foreign
          securities depositories designated on Schedule A hereto ("foreign
          sub-custodians"). Upon receipt of "Proper Instructions", as defined in
          Section 5 of this Contract, together with a certified resolution of
          the Fund's Board of Trustees, the Custodian and the Fund may agree to
          amend Schedule A hereto from time to time to designate additional
          foreign banking institutions and foreign securities depositories to
          act as sub-custodian. Upon receipt of Proper Instructions, the Fund
          may instruct the Custodian to cease the employment of any one or more
          such sub-custodians for maintaining custody of the Fund's assets.
          

3.2       ASSETS TO BE HELD. The Custodian shall limit the securities and other
          assets maintained in the custody of the foreign sub-custodians to: (a)
          "foreign securities", as defined in paragraph (c)(1) of Rule 17f-5
          under the Investment Company Act of 1940, and (b) cash and cash
          equivalents in such amounts as the Custodian or the Fund may determine
          to be reasonably necessary to effect the Fund's foreign securities
          transactions.




                                     - 22 -
<PAGE>

3.3       FOREIGN SECURITIES DEPOSITORIES. Except as may otherwise be agreed
          upon in writing by the Custodian and the Fund, assets of the Fund
          shall be maintained in foreign securities depositories only through
          arrangements implemented by the foreign banking institutions serving
          as sub-custodians pursuant to the terms hereof. where possible, such
          arrangements shall include entry into agreements containing the
          provisions set forth in Section 3.5 hereof. 

3.4       SEGREGATION OF SECURITIES 
          The Custodian shall identify on its books as belonging to the Fund,
          the foreign securities of the Fund held by each foreign sub-custodian.
          Each agreement pursuant to which the Custodian employs a foreign
          banking institution shall require that such institution establish a
          custody account for the Custodian on behalf of the Fund and physically
          segregate in that account, securities and other assets of the Fund,
          and, in the event that such institution deposits the Fund's securities
          in a foreign securities depository, that it shall identify on its
          books as belonging to the Custodian, as agent for the Fund, the
          securities so deposited.

3.5       AGREEMENTS WITH FOREIGN BANKING INSTITUTIONS. Each agreement with a
          foreign banking institution shall be substantially in the form set
          forth in Exhibit 1 hereto and shall provide that: (a) the Fund's
          assets will not be subject to any right, charge, security interest,
          

                                     - 23 -
<PAGE>

          lien or claim of any kind in favor of the foreign banking institution
          or its creditors or agent, except a claim of payment for their safe
          custody or administration; (b) beneficial ownership of the Fund's
          assets will be freely transferable without the payment of money or
          value other than for custody or administration; (c) adequate records
          will be maintained identifying the assets as belonging to the Fund;
          (d) officers of or auditors employed by, or other representatives of
          the Custodian, including to the extent permitted under applicable law
          the independent public accountants for the Fund, will be given access
          to the books and records of the foreign banking institution relating
          to its actions under its agreement with the Custodian; and (e) assets
          of the Fund held by the foreign sub-custodian will be subject only to
          the instructions of the Custodian or its agents. 

3.6       ACCESS OF INDEPENDENT ACCOUNTANTS OF THE FUND. Upon request of the
          Fund, the Custodian will use its best efforts to arrange for the
          independent accountants of the Fund to be afforded access to the books
          and records of any foreign banking institution employed as a foreign
          sub-custodian insofar as such books and records relate to the
          performance of such foreign banking institution under its agreement
          with the Custodian. 

3.7       REPORTS BY CUSTODIAN. The Custodian will supply to the Fund from time
          to time, as mutually agreed upon, statements in respect of the
          securities and other assets of the Fund held by foreign


                                     - 24 -
<PAGE>

          sub-custodians, including but not limited to an identification of
          entities having possession of the Fund's securities and other assets
          and advices or notifications of any transfers of securities to or from
          each custodial account maintained by a foreign banking institution for
          the Custodian on behalf of the Fund indicating, as to securities
          acquired for the Fund, the identity of the entity having physical
          possession of such securities. 

3.8       TRANSACTIONS IN FOREIGN CUSTODY ACCOUNT

          (a) Except as otherwise provided in paragraph (b) of this Section 3.8,
          the provision of Sections 2.2 and 2.7 of this Contract shall apply,
          MUTATIS MUTANDIS to the foreign securities of the Fund held outside
          the United States by foreign sub-custodians.

          (b) Notwithstanding any provision of this Contract to the contrary,
          settlement and payment for securities received for the account of the
          Fund and delivery of securities maintained for the account of the Fund
          may be effected in accordance with the customary established
          securities trading or securities processing practices and procedures
          in the jurisdiction or market in which the transaction occurs,
          including, without limitation, delivering securities to the purchaser
          thereof or to a dealer therefor (or an agent for such purchaser or
          dealer) against a receipt with the expectation of receiving later
          payment for such securities from such purchaser or dealer.


                                     - 25 -
<PAGE>


          (c) Securities maintained in the custody of a foreign sub-custodian
          may be maintained in the name of such entity's nominee to the same
          extent as set forth in Section 2.3 of this Contract, and the Fund
          agrees to hold any such nominee harmless from any liability as a
          holder of record of such securities. 

3.9       LIABILITY OF FOREIGN SUB-CUSTODIANS. Each agreement pursuant to which
          the Custodian employs a foreign banking institution as a foreign
          sub-custodian shall require the institution to exercise reasonable
          care in the performance of its duties and to indemnify, and hold
          harmless, the Custodian and each Fund from and against any loss,
          damage, cost, expense, liability or claim arising out of or in
          connection with the institution's performance of such obligations. At
          the election of the Fund, it shall be entitled to be subrogated to the
          rights of the Custodian with respect to any claims against a foreign
          banking institution as a consequence of any such loss, damage, cost,
          expense, liability or claim if and to the extent that the Fund has not
          been made whole for any such loss, damage, cost, expense, liability or
          claim. 

3.10      LIABILITY OF CUSTODIAN. The Custodian shall be liable for the acts or
          omissions of a foreign banking institution to the same extent as set
          forth with respect to sub-custodians generally in this Contract and,
          regardless of whether assets are maintained in the custody of a
          foreign banking institution, a foreign securities depository or a





                                     - 26 -
<PAGE>

          branch of a U.S. bank as contemplated by paragraph 3.13 hereof, the
          Custodian shall not be liable for any loss, damage, cost, expense,
          liability or claim resulting from nationalization, expropriation,
          currency restrictions, or acts of war or terrorism or any loss where
          the sub-custodian has otherwise exercised reasonable care.
          Notwithstanding the foregoing provisions of this paragraph 3.10, in
          delegating custody duties to State Street London Ltd., the Custodian
          shall not be relieved of any responsibility to the Fund for any loss
          due to such delegation, except such loss as may result from (a)
          political risk (including, but not limited to, exchange control
          restrictions, confiscation, expropriation, nationalization,
          insurrection, civil strife or armed hostilities) or (b) other losses
          (excluding a bankruptcy or insolvency of State Street London Ltd. not
          caused by political risk) due to Acts of God, nuclear incident or
          other losses under circumstances where the Custodian and State Street
          London Ltd. have exercised reasonable care.

3.11      REIMBURSEMENT FOR ADVANCES. If the Fund requires the Custodian to
          advance cash or securities for any purpose including the purchase or
          sale of foreign exchange or of contracts for foreign exchange, or in
          the event that the Custodian or its nominee shall incur or be assessed
          any taxes, charges, expenses, assessments, claims or liabilities in
          connection with the performance of this Contract, except such as may



                                     - 27 -
<PAGE>

          arise from its or its nominee's own negligent action, negligent
          failure to act or willful misconduct, any property at any time held
          for the account of the Fund shall be security therefor and should the
          Fund fail to repay the Custodian promptly, the Custodian shall be
          entitled to utilize available cash and to dispose of the Fund assets
          to the extent necessary to obtain reimbursement.

3.12      MONITORING RESPONSIBILITIES. The Custodian shall furnish annually to
          the Fund, during the month of June, information concerning the foreign
          sub-custodians employed by the Custodian. Such information shall be
          similar in kind and scope to that furnished to the Fund in connection
          with the initial approval of this Contract. In addition, the Custodian
          will promptly inform the Fund in the event that the Custodian learns
          of a material adverse change in the financial condition of a foreign
          sub-custodian or any material loss of the assets of the Fund or in the
          case of any foreign sub-custodian not the subject of an exemptive
          order from the Securities and Exchange Commission is notified by such
          foreign sub-custodian that there appears to be a substantial
          likelihood that its shareholders' equity will decline below $200
          million (U.S. dollars or the equivalent thereof) or that its
          shareholders' equity has declined below $200 million (in each case
          computed in accordance with generally accepted U.S. accounting
          principles).




                                     - 28 -
<PAGE>

3.13      BRANCHES OF U.S. BANKS

          (a) Except as otherwise set forth in this Contract, the provisions
          hereof shall not apply where the custody of the Fund assets are
          maintained in a foreign branch of a banking institution which is a
          "bank" as defined by Section 2(a)(5) of the Investment Company Act of
          1940 meeting the qualification set forth in Section 26(a) of said Act.
          The appointment of any such branch as a sub-custodian shall be
          governed by paragraph 1 of this Contract. 

          (b) Cash held for the Fund in the United Kingdom shall be maintained
          in an interest bearing account established for the Fund with the
          Custodian's London branch, which account shall be subject to the
          direction of the Custodian, State Street London Ltd. or both. 

3.14      TAX LAW 

          The Custodian shall have no responsibility or liability for any
          obligations now or hereafter imposed on the Fund or the Custodian as
          custodian of the Fund by the tax law of the United States of America
          or any state or political subdivision thereof. It shall be the
          responsibility of the Fund to notify the Custodian of the obligations
          imposed on the Fund or the Custodian as custodian of the Fund by the
          tax law of jurisdictions other than those mentioned in the above
          sentence, including responsibility for withholding and other taxes,
          assessments or other governmental charges, certifications and


                                     - 29 -
<PAGE>

          governmental reporting. The sole responsibility of the Custodian with
          regard to such tax law shall be to use reasonable efforts to assist
          the Fund with respect to any claim for exemption or refund under the
          tax law of jurisdictions for which the Fund has provided such
          information.

4.        PAYMENTS FOR REPURCHASES OR REDEMPTIONS AND SALES OF SHARES OF THE 
FUND

          From such funds as may be available for the purpose but subject to the
limitations of the Declaration of Trust and any applicable votes of the Board of
Trustees of the Fund pursuant thereto, the Custodian shall, upon receipt of
instructions from the Transfer Agent, make funds available for payment to
holders of Shares who have delivered to the Transfer Agent a request for
redemption or repurchase of their Shares. In connection with the redemption or
repurchase of Shares of the Fund, the Custodian is authorized upon receipt of
instructions from the Transfer Agent to wire funds to or through a commercial
bank designated by the redeeming shareholders. In connection with the redemption
or repurchase of Shares of the Fund, the Custodian shall honor checks drawn on
the Custodian by a holder of Shares, which checks have been furnished by the
Fund to the holder of Shares, when presented to the Custodian in accordance with
such procedures and controls as are mutually agreed upon from time to time
between the Fund and the Custodian. 

          The Custodian shall receive from the distributor for the Fund's Shares
or from the Transfer Agent of the Fund and deposit into the Fund's account such
payments as are received for Shares of the Fund issued or sold from time to time



                                     - 30 -
<PAGE>

by the Fund. The Custodian will provide timely notification to the Fund and the
Transfer Agent of any receipt by it of payments for Shares of the Fund.

5.        PROPER INSTRUCTIONS

          Proper Instructions as used herein means a writing signed or initialed
by one or more person or persons as the Board of Trustees shall have from time
to time authorized. Each such writing shall set forth the specific transaction
or type of transaction involved, including a specific statement of the purpose
for which such action is requested. Oral instructions will be considered Proper
Instructions if the Custodian reasonably believes them to have been given by a
person authorized to give such instructions with respect to the transaction
involved. The Fund shall cause all oral instructions to be confirmed in writing.
Upon receipt of a certificate of the Secretary or an Assistant Secretary as to
the authorization by the Board of Trustees of the Fund accompanied by a detailed
description of procedures approved by the Board of Trustees, Proper Instructions
may include communications effected directly between electro-mechanical or
electronic devices provided that the Board of Trustees and the Custodian are
satisfied that such procedures afford adequate safeguards for the Fund's assets.
For purposes of this Section, Proper Instructions shall include instructions
received by the Custodian pursuant to any three party agreement which requires a
segregated asset account in accordance with Section 2.11.



                                     - 31 -
<PAGE>
6.        ACTIONS PERMITTED WITHOUT EXPRESS AUTHORITY

          The Custodian may in its discretion, without express authority from
the Fund:

          1)     make payments to itself or others for minor expenses of
handling securities or other similar items relating to its duties under this
Contract, PROVIDED that all such payments shall be accounted for to the Fund;

          2)     surrender securities in temporary form for securities in
definitive form;

          3)     endorse for collection, in the name of the Fund, checks, drafts
and other negotiable instruments; and

          4)     in general, attend to all non-discretionary details in
connection with the sale, exchange, substitution, purchase, transfer and other
dealings with the securities and property of the Fund except as otherwise
directed by the Board of Trustees of the Fund. 

7.        EVIDENCE OF AUTHORITY

          The Custodian shall be protected in acting upon any instructions,
notice, request, consent, certificate or other instrument or paper believed by
it to be genuine and to have been properly executed by or on behalf of the Fund.
The Custodian may receive and accept a certified copy of a vote of the Board of
Trustees of the Fund as conclusive evidence (a) of the authority of any person
to act in accordance with such vote or (b) of any determination or of any action
by the Board of Trustees pursuant to the Declaration of Trust as described in
such vote, and such vote may be considered as in full force and effect until
receipt by the Custodian of written notice to the contrary.




                                     - 32 -
<PAGE>

8.        DUTIES OF CUSTODIAN WITH RESPECT TO THE BOOKS OF ACCOUNT
AND CALCULATION OF NET ASSET VALUE AND NET INCOME

          The Custodian shall cooperate with and supply necessary information to
the entity or entities appointed by the Board of Trustees of the Fund to keep
the books of account of the Fund and/or compute the net asset value per share of
the outstanding shares of the Fund or, if directed in writing to do so by the
Fund, shall itself keep such books of account and/or compute such net asset
value per share. If so directed, the Custodian shall also calculate daily the
net income of the Fund as described in the Fund's currently effective prospectus
and shall advise the Fund and the Transfer Agent daily of the total amounts of
such net income and, if instructed in writing by an officer of the Fund to do
so, shall advise the Transfer Agent periodically of the division of such net
income among its various components. The calculations of the net asset value per
share and the daily income of the Fund shall be made at the time or times
described from time to time in the Fund's currently effective prospectus. 

9.        RECORDS

          The Custodian shall create and maintain all records relating to its
activities and obligations under this Contract in such manner as will meet the
obligations of the Fund under the Investment Company Act of 1940, with
particular attention to Section 31 thereof and Rules 31a-1 and 31a-2 thereunder.
All such records shall be the property of the Fund and shall at all times during
the regular business hours of the Custodian be open for inspection by duly
authorized officers, employees or agents of the Fund and employees and agents of


                                     - 33 -
<PAGE>

the Securities and Exchange Commission. The Custodian shall, at the Fund's
request, supply the Fund with a tabulation of securities owned by the Fund and
held by the Custodian and shall, when requested to do so by the Fund and for
such compensation as shall be agreed upon between the Fund and the Custodian,
include certificate numbers in such tabulations. 

10.       OPINION OF FUND'S INDEPENDENT ACCOUNTANT

          The Custodian shall take all reasonable action, as the Fund may from
time to time request, to obtain from year to year favorable opinions from the
Fund's independent accountants with respect to its activities hereunder in
connection with the preparation of the Fund's Form N-1A, and Form N-SAR or other
annual reports to the Securities and Exchange Commission and with respect to any
other requirements of such Commission.


11.       COMPENSATION OF CUSTODIAN

          The Custodian shall be entitled to reasonable compensation for its
services and expenses as Custodian, as agreed upon from time to time between the
Fund and the Custodian.


12.       RESPONSIBILITY OF CUSTODIAN

          So long as and to the extent that it is in the exercise of reasonable
care, the Custodian shall not be responsible for the title, validity or
genuineness of any property or evidence of title thereto received by it or
delivered by it pursuant to this Contract and shall be held harmless in acting
upon any notice, request, consent, certificate or other instrument reasonably
believed by it to be genuine and to be signed by the proper party or parties,


                                     - 34 -
<PAGE>

including any futures commission merchant acting pursuant to the terms of a
three-party futures or options agreement. The Custodian shall be held to the
exercise of reasonable care in carrying out the provisions of this Contract, but
shall be kept indemnified by and shall be without liability to the Fund for any
action taken or omitted by it in good faith without negligence. It shall be
entitled to rely on and may act upon advice of counsel (who may be counsel for
the Fund) on all matters, and shall be without liability for any action
reasonably taken or omitted pursuant to such advice.

          The Custodian shall be liable for the acts or omissions of a foreign
banking institution appointed pursuant to the provisions of Article 3 to the
same extent as set forth in Article 1 hereof with respect to sub-custodians
located in the United States and, regardless of whether assets are maintained in
the custody of a foreign banking institution, a foreign securities depository or
a branch of a U.S. bank as contemplated by paragraph 3.11 hereof, the Custodian
shall not be liable for any loss, damage, cost, expense, liability or claim
resulting from, or caused by, the direction of or authorization by the Fund to
maintain custody or any securities or cash of the Fund in a foreign country
including, but not limited to, losses resulting from nationalization,
expropriation, currency restrictions, or acts of war or terrorism.

          If   the   Fund requires  the  Custodian to take   any   action   with
respect to securities, which action involves the payment of, money or which
action may, in the opinion of the Custodian,


                                     - 35 -
<PAGE>

result in the  Custodian  or its nominee assigned  to the  Fund being liable
for  the payment of money  or incurring  liability  of some other form,
the Fund,  as a prerequisite to requiring the Custodian to  take such
action, shall provide indemnity to the Custodian in an amount and form
satisfactory to it.

          If the Fund requires the Custodian, its affiliates, subsidiaries or
agents, to advance cash or securities for any purpose (including but not limited
to securities settlements, foreign exchange contracts and assumed settlement) or
in the event that the Custodian or its nominee shall incur or be assessed any
taxes, charges, expenses, assessments, claims or liabilities in connection with
the performance of this Contract, except such as may arise from its or its
nominee's own negligent action, negligent failure to act or willful misconduct,
any property at any time held for the account of the Fund shall be security
therefor and should the Fund fail to repay the Custodian promptly, the Custodian
shall be entitled to utilize available cash and to dispose of the Fund assets to
the extent necessary to obtain reimbursement. 

13.       EFFECTIVE PERIOD, TERMINATION AND AMENDMENT

          This Contract shall become effective as of its execution, shall
continue in full force and effect until terminated as hereinafter provided, may
be amended at any time by mutual agreement of the parties hereto and may be
terminated by either party by an instrument in writing delivered or mailed,
postage prepaid to the other party, such termination to take effect not sooner
than thirty (30) days after the date of such delivery or mailing; PROVIDED,


                                     - 36-
<PAGE>

however that the Custodian shall not act under Section 2.10 hereof in the
absence of receipt of an initial certificate of the Secretary or an Assistant
Secretary that the Board of Trustees of the Fund has approved the initial use of
a particular Securities System and the receipt of an annual certificate of the
Secretary or an Assistant Secretary that the Board of Trustees has reviewed the
use by the Fund of such Securities System, as required in each case by Rule
17f-4 under the Investment Company Act of 1940, as amended and that the
Custodian shall not act under Section 2.10A hereof in the absence of receipt of
an initial certificate of the Secretary or an Assistant Secretary that the Board
of Trustees has approved the initial use of the Direct Paper System and the
receipt of an annual certificate of the Secretary or an Assistant Secretary that
the Board of Trustees has reviewed the use by the Fund of the Direct Paper
System; PROVIDED FURTHER, however, that the Fund shall not amend or terminate
this Contract in contravention of any applicable federal or state regulations,
or any provision of the Declaration of Trust, and further provided, that the
Fund may at any time by action of its Board of Trustees (i) substitute another
bank or trust company for the Custodian by giving notice as described above to
the Custodian, or (ii) immediately terminate this Contract in the event of the
appointment of a conservator or receiver for the Custodian by the Comptroller of
the Currency or upon the happening of a like event at the direction of an
appropriate regulatory agency or court of competent jurisdiction.



                                     - 37 -
<PAGE>

          Upon termination of the Contract, the Fund shall pay to the Custodian
such compensation as may be due as of the date of such termination and shall
likewise reimburse the Custodian for its costs, expenses and disbursements.


14.       SUCCESSOR CUSTODIAN

          If a successor custodian shall be appointed by the Board of Trustees
of the Fund, the Custodian shall, upon termination, deliver to such successor
custodian at the office of the Custodian, duly endorsed and in the form for
transfer, all securities then held by it hereunder and shall transfer to an
account of the successor custodian all of the Fund's securities held in a
Securities System.

          If no such successor custodian shall be appointed, the Custodian
shall, in like manner, upon receipt of a certified copy of a vote of the Board
of Trustees of the Fund, deliver at the office of the Custodian and transfer
such securities, funds and other properties in accordance with such vote.

          In the event that no written order designating a successor custodian
or certified copy of a vote of the Board of Trustees shall have been delivered
to the Custodian on or before the date when such termination shall become
effective, then the Custodian shall have the right to deliver to a bank or trust
company, which is a "bank" as defined in the Investment Company Act of 1940,
doing business in Boston, Massachusetts, of its own selection, having an
aggregate capital, surplus, and undivided profits, as shown by its last
published report, of not less than $25,000,000, all securities, funds and other


                                     - 38 -
<PAGE>

properties held by the Custodian and all instruments held by the Custodian
relative thereto and all other property held by it under this Contract and to
transfer to an account of such successor custodian all of the Fund's securities
held in any Securities System. Thereafter, such back or trust company shall be
the successor of the Custodian under this Contract.

          In the event that securities, funds and other properties remain in the
possession of the Custodian after the date of termination hereof owing to
failure of the Fund to procure the certified copy of the vote referred to or of
the Board of Trustees to appoint a successor custodian, the Custodian shall be
entitled to fair compensation for its services during such period as the
Custodian retains possession of such securities, funds and other properties and
the provisions of this Contract relating to the duties and obligations of the
Custodian shall remain in full force and effect.

15.       INTERPRETIVE AND ADDITIONAL PROVISIONS

          In connection with the operation of this Contract, the Custodian and
the Fund may from time to time agree on such provisions interpretive of or in
addition to the provisions of this Contract as may in their joint opinion be
consistent with the general tenor of this Contract. Any such interpretive or
additional provisions shall be in a writing signed by both parties and shall be
annexed hereto, provided that no such interpretive or additional provisions
shall contravene any applicable federal or state regulations or any provision of
the Declaration of Trust of the Fund. No interpretive or additional provisions


                                     - 39 -
<PAGE>

made as provided in the preceding sentence shall be deemed to be an amendment of
this Contract.
        
 16.      MASSACHUSETTS LAW TO APPLY

          This  Contract  shall   be  construed   and  the provisions thereof
interpreted under and in accordance with laws of the Commonwealth of
Massachusetts.


17.       LIMITATIONS OF LIABILITY OF THE TRUSTEES AND SHAREHOLDERS

          A copy of the Declaration of Trust of the Trust is on file with the
Secretary of the Commonwealth of Massachusetts, and notice is hereby given that
this instrument is executed on behalf of the Trustees of the Trust as Trustees
and not individually and that the obligations of this instrument are not binding
upon any of the Trustees or Shareholders individually but are binding only upon
the assets and property of the Fund.

18.       PRIOR CONTRACTS
         
          This Contract supersedes and terminates, as of the date hereof, all
prior contracts between the Fund and the Custodian relating to the custody of
the Fund's assets. 




                                     - 40 -
<PAGE>


          IN WITNESS WHEREOF, each of the parties has caused this instrument to
be executed in its name and behalf by its duly authorized representative and its
seal to be hereunder affixed as of the 16th day of January 1991.



ATTEST                                       THE GLOBAL HEALTH SCIENCES FUND


/s/ Glen A. Payne                            By:/s/ John J. Kaweske
- -----------------------------                   -------------------------------
Glen A. Payne                                   John J. Kaweske



ATTEST                                       STATE STREET BANK AND TRUST COMPANY

/s/ Maureen A. Rodriguez                     By:/s/ Charles N. Whittemore, Jr.
- -----------------------------                   --------------------------------
Assistant Secretary                             Vice President




                                     - 41 -
<PAGE>

                                   SCHEDULE A
                                   ----------

The following foreign banking institutions and foreign securities depositories
have been approved by the Board of Trustees of The Global Health Sciences Fund
(the "Fund") for use as sub-custodians for the Fund's securities and other
assets:

                       FOREIGN
COUNTRY           SUB-CUSTODIAN BANK              APPLICABLE DEPOSITORY
- -------           ------------------              ---------------------
Argentina         Citibank, N.A.                  Caja de Valores              
                                                  
Australia         Australia and New Zealand       Austraclear Limited
                  Banking Group Limited           
                                                  
Austria           Girozentrale Und Bank           Oesterreichischen
                  Der Osterreichischen            Kontrollbank AG
                  Sparkassen AG                   Wertpapiersammelbank
                                                  Beider (OeKB-WSb)
                                                  
Belgium           Banque Bruxelles                Caisse
                  Lambert                         Interprofessionelle
                                                  de Depots et de
                                                  Virements de Titres
                                                  S.A. (C.I.K.)
                                                  
Brazil            Citibank, N.A.                  Bolsa de Valores de
                                                  Sao Paulo (Bovespa)
                                                  
Canada            Canada Trust Company            The Canadian
                                                  Depository for
                                                  Securities Ltd. (CDS)
                                                  
Chile             Citibank, N.A.                  
                                                  
Denmark           Den Danske Bank                 Vaerdipapircentralen
                                                  (VP-Centralen)
                                                  
Finland           Kansallis-Osake Pankki          
                                                  
France            Credit Commercial de            Societe
                  France                          Interprofessionnelle
                                                  pour la Compensation
                                                  des Valeurs
                                                  Mibilieres (SICOVAM)
                                                  
Germany           Berliner Handels-und            The Kassenverein AG
                  Frankfurter Bank                
                                                  
Greece            National Bank of Greece         The Depository of
                                                  Registered Securities
                                                  



<PAGE>


                       FOREIGN
COUNTRY           SUB-CUSTODIAN BANK              APPLICABLE DEPOSITORY
- -------           ------------------              ---------------------

Hong Kong         Standard Chartered Bank         
                                                  
Indonesia         Standard Chartered Bank         
                                                  
Ireland           Bank of Ireland                 The Gilts Settlement
                                                  Office
                                                  
Italy             Credito Italiano                Monte Titoli, SpA
                                                  
Japan             Sumitomo Trust &                
                  Banking Company, Ltd.           
                                                  
Malaysia          Standard Chartered Bank         
                                                  
Mexico            Citibank Mexico                 Instituto para el
                                                  Deposito de Valores
                                                  (INDEVAL)
                                                  
Netherlands       Bank Mees & Hope, N.V.          Netherlands Clearing
                                                  Institute for Giro
                                                  Securities Deliveries
                                                  (NECIGEF)
                                                  
New Zealand       Westpac Banking Corp.           
                                                  
Norway            Christiania Bank OG             The Norwegian
                  Kreditkasse                     Registry of
                                                  Securities,
                                                  Verdipapirsentralen
                                                  (VPS )
                                                  
Philippines       Standard Chartered Bank         
                                                  
Portugal          Banco Comercial Portugues       
                                                  
Singapore         The Development Bank of         
                  Singapore Ltd.                  
                                                  
Spain             Banko Hispano Americano         
                                                  
Sweden            Skandinaviska Enskilda          Vardepapperscentralen
                  Banken           (VPS)
                                                  
                                                  
Switzerland       Union Bank of Switzerland       Schweizerische Effekten 
                                                  Giro A.G. (SEGA)
                                                  


<PAGE>

                       FOREIGN
COUNTRY           SUB-CUSTODIAN BANK              APPLICABLE DEPOSITORY
- -------           ------------------              ---------------------

Taiwan            Central Trust of China          
                                                  
Thailand          Standard Chartered Bank         
                                                  
Turkey            Citibank, N.A.                  
                                                  
United            State Street London             The Central Gilts
Kingdom           Limited                         Office (CGO)
                                                  
Venezuela         Citibank, N.A.                  
                                                  
Numerous                                          Cedel
                                                  
Numerous                                          Euro-Clear
                                              


 


I certify that the above was approved at the Board of Trustees' meeting of The
Global Health Sciences Fund on December 5, 1991.


                                           /s/ Glen A. Payne
                                           ------------------------------
                                           Glen A. Payne, Secretary




[SEAL]

January 23, 1992



                        SPECIAL CUSTODY ACCOUNT AGREEMENT
                        ---------------------------------

                                  (Short Sales)

      AGREEMENT,  dated as of January 13,  1998,  by and among State Street Bank
and Trust Company, in its capacity as custodian hereunder (the "Bank"),  INVESCO
Global Health Sciences Fund (the "Customer") and Bear,  Sterns  Securities Corp.
(the "Broker").

      WHEREAS,  Broker is a securities  broker-dealer and is a member of several
national securities exchanges;

      WHEREAS,  Customer  is a  Registered  Investment  Company  pursuant to the
Investment Company Act of 1940 and Rules promulgated thereunder;

      WHEREAS,  Customer  desires from time to time to sell  securities  "short"
through  Broker,  such short  sales being  permitted  by  Customer's  investment
policies,  and for that  purpose  has  executed  Broker's  Professional  Account
Agreement (the "Customer Agreement"), which provides for margin transactions;

      WHEREAS,  to  facilitate   Customer's   transactions  in  short  sales  of
securities,   Customer  and  Broker  desire  to  establish  procedures  for  the
compliance  by  Broker  with the  provisions  of  Regulation  T of the  Board of
Governors  of the  Federal  Reserve  System  and other  applicable  requirements
(the "Margin Rules"); and

      WHEREAS, to assist Broker and Customer in complying with the Margin Rules,
Bank is prepared to act as custodian to hold Collateral as defined below.

      NOW, THEREFORE, be it agreed as follows:

1 .   DEFINITIONS
      -----------

      As used herein, the following terms have the following meanings:

      (a)   "Adequate Margin" in respect of short sales means such Collateral as
            is adequate in Broker's  reasonable  judgment under the Margin Rules
            and the internal policies of Broker.

      (b)   "Advice  from  Broker" or  "Advice"  means a written  notice sent to
            Customer  and Bank or  transmitted  by a facsimile  sending  device,
            except that the Advice for initial or additional  Collateral or with
            respect to Broker's  ability to effect a short sale for Customer may
            be  given  orally.  With  respect  to  any  short  sale  or  Closing
            Transaction,   the  Advice  from   Broker   shall  mean  a  standard
            confirmation  in use by Broker and sent or  transmitted  to Customer
            and Bank. With respect to  substitutions  or releases of Collateral,
            Advice from Broker means a written  notice signed by Broker and sent
            or transmitted  to Customer and Bank. An authorized  agent of Broker
            will certify to Customer and Bank the names and  signatures of those
            employees  who are  authorized  to sign Advices  from Broker,  which
            certification  may be amended  from time to time.  When used herein,
            the term "Advice" means the act of sending an Advice from Broker.

      (c)   "Closing   Transaction"   means  a  transaction  in  which  Customer
            purchases securities which have been sold short.



                                       
<PAGE>


      (d)   "Collateral" means cash or U.S. Government  securities or other U.S.
            securities acceptable to Broker.

      (e)   "Custody  Agreement"  means  the  agreement  for  general  custodial
            services between Bank and Customer.

      (f)   "Insolvency"  means that (A) an order,  judgment  or decree has been
            entered   under   the   bankruptcy,   reorganization,    compromise,
            arrangement,   insolvency,  readjustment  of  debt,  dissolution  or
            liquidation or similar law (herein called the  "Bankruptcy  Law") of
            any competent jurisdiction  adjudicating the Customer Insolvent; (B)
            the  Customer  has  petitioned  or applied to any  tribunal  for, or
            consented to the appointment of, or taking possession by, a trustee,
            receiver,   liquidator  or   similar  official,  of   the  Customer,
            commenced a voluntary  case under the  Bankruptcy  Law of the United
            States  or any  proceedings  relating  to  the  customer  under  the
            Bankruptcy Law of any other competent  jurisdiction,  whether now or
            hereinafter in affect;  or (C) any such petition or application  has
            been filed, or any such proceedings commenced,  against the Customer
            and the  Customer by any act has  indicated  its  approval  thereof,
            consent thereto or acquiescence  therein, or an order for relief has
            been entered in an involuntary  case under the Bankruptcy Law of the
            United  States,  as now or  hereinafter  constituted,  or any order,
            judgment  or decree  has been  entered  appointing  any such  trust,
            receiver,  liquidator or similar official, or approving the petition
            in any such proceedings,  and such order, judgment or decree remains
            unseated and in effect for more than 60 days.

      (g)   "Instructions  from  Customer"  or  "Instructions"  means a request,
            direction  or  certification  in  writing  signed  by  Customer  and
            delivered to Bank and Broker or transmitted  by a facsimile  sending
            device.  An officer of Customer  will certify to Bank and Broker the
            names  and  signatures  of  those  persons  authorized  to sign  the
            instructions,  which certification may be amended from time to time.
            When used herein,  the term "Instruct" shall mean the act of sending
            an Instruction from Customer.

      (h)   "Receipt of  Payment"  means  receipt by Bank of (1) a certified  or
            official  bank  check or wire  transfer  to Bank;  (2) a written  or
            telegraphic advice from a registered clearing agency that funds have
            been or will be credited  to the account of Bank,  or (3) a transfer
            of funds from any of Broker's accounts maintained at Bank.

      (i)   "Receipt of Securities"  means receipt by Bank, of (1) securities in
            proper form for transfer or (2) a written or telegraphic advice from
            a registered  clearing  agency that securities have been credited to
            the account of Bank of the Special Custody Account.

      (j)   "Special  Custody  Account" shall have the meaning  assigned to that
            term in Section 2 hereof.

2.     SPECIAL CUSTODY ACCOUNT
       -----------------------

      (a)   OPENING  CUSTODY  ACCOUNT.  Bank  shall open an account on its books
            entitled  "Special Custody Account for Bear, Steams Securities Corp.
            as Pledgee of INVESCO  Global  Health  Sciences  Fund" (the "Special
            Custody  Account"),  which  shall  be a  sub-account  of  Customer's
            custody account with Bank, and shall hold therein all securities and
            similar  property  as shall be received  and  accepted by it therein
            pursuant to this  Agreement.  Customer  agrees to  instruct  Bank in

                                       2
<PAGE>


            Instructions from Customer as to cash and specific  securities which
            Bank is to identify on its books and records as pledged to Broker as
            Collateral in the Special Custody Account.  Customer agrees that the
            value of such cash and  securities  shall be at least equal in value
            to what Broker shall initially and from time to time advise Customer
            in an Advice from Broker is necessary to constitute Adequate Margin.
            Such  collateral  (i)  will be held by Bank for  Broker  as agent of
            Broker,  (ii) may be released only in  accordance  with the terms of
            this Agreement and (iii) except as required to be released hereunder
            to  Broker,  shall not be made  available  to Broker or to any other
            person  claiming  through  Broker,  including  the  creditors of the
            Broker. In the event Customer wishes to open another Special Custody
            Account for another  series of the Fund pursuant to this  Agreement,
            the title of said account shall be appended  hereto as a schedule to
            this Agreement.

      (b)   SECURITY  INTEREST.  Customer  hereby  grants a continuing  security
            interest to Broker in the Collateral in the Special Custody Account.
            To perfect Broker's security Interest, Bank will hold the Collateral
            in the Special Custody  Account,  subject to the interest therein of
            Broker as the pledgee and secured party  thereof in accordance  with
            the terms of this Agreement.  Such security  interest will terminate
            at such time as  Collateral  is released as  provided  herein.  Bank
            shall have no  responsibility  for the validity or enforceability of
            such security interest.

      (c)   CONFIRMATION.  Bank will  confirm in writing to Broker and  Customer
            all pledges, releases or substitutions of Collateral and will supply
            Broker and  Customer  with a monthly  statement  of  Collateral  and
            transaction in the Special Custody Account for such month. Bank will
            also advise Broker upon request of the kind and amount of Collateral
            pledged to Broker.

      (d)   EXCESS COLLATERAL. Upon the request of Customer, Broker shall advise
            Bank and customer of any excess of Collateral in the Special Custody
            Account.  Such excess  shall at  Customer's  request be  transferred
            therefrom upon Advice from Broker.

      (e)   ACCOUNTS AND RECORDS.  Bank will  maintain  accounts and records for
            the  Collateral  in  the  Special  Custody  Account  as  more  fully
            described in subparagraph  5(a) below.  The Collateral  shall at all
            times remain the property of the Customer subject only to the extent
            of the interest and rights therein of Broker as the pledgee thereof.

3.    ORIGINAL AND VARIATION MARGIN ON SHORT SALES
      --------------------------------------------

      (a)   SHORT SALES. From time to time, Customer may place order with Broker
            for the short sale of  securities.  Prior to the  acceptance of such
            orders,  Broker will advise  Customer of Broker's  ability to borrow
            such  securities or other  properties  and  acceptance of short sale
            orders will be contingent upon same.

      (b)   OPEN SHORT SALES BALANCE.  Broker shall, based on the closing market
            price on each  business  day,  compute the  aggregate  net credit or
            debit  balance on  Customer's  open short sales and advise  Customer
            and/or  Customer's  designated  agent by 11:00 A.M. New York time on
            the next business day (each a "Determination Day"), of the amount of
            the net debit or credit,  as the case may be. If a net debit balance
            exists on a Determination  Day,  Customer will cause an amount equal
            to such net  debit  balance  to be paid to  Broker  by the  close of

                                       3
<PAGE>


            business on such  Determination  Day. If a net credit balance exists
            on a  Determination  Day,  Broker  will pay such  credit  balance to
            Customer  by the close of  business  on such  Determination  Day. As
            Customer's open short positions are  marked-to-market  each business
            day,  payments will be made by or to Customer to reflect changes (if
            any) in the credit or debit balances. Broker will charge interest on
            any debit  balances,  and  Broker  will pay  interest  on any credit
            balances.  Balances will be appropriately  adjusted when short sales
            are closed out.

4.     PLACING ORDERS
       --------------

       It is understood and agreed that  Customer,  when placing with Broker any
order to sell short for Customer's account, will designate the order as such and
hereby authorizes  Broker to mark such order as being "short",  and when placing
with Broker any order to sell long for  Customer's  account,  will designate the
order as such and hereby  authorizes  Broker to mark such order as being "long".
Any sell order which Customer shall designate as being for long account as above
provided is for  securities  then owned by Customer and, if such  securities are
not then deliverable by Broker from any account of Customer, the placing of such
order shall constitute a representation by Customer that it is impracticable for
Customer  than to deliver  such  securities  to Broker but that  Customer  shall
deliver them by the settlement date or as soon as possible thereafter.

5.    RIGHTS AND DUTIES OF THE BANK
      -----------------------------

      (a)   GENERALLY.  The Bank shall  receive and hold in the Special  Custody
            Account,  as  custodian  upon  the  terms  of  this  Agreement,  all
            Collateral  deposited and  maintained  pursuant to the terms of this
            Agreement and, except as provided in subparagraph 5(b) below,  shall
            receive and hold all monies and other property paid,  distributed or
            substituted in respect of such Collateral or realized on the sale or
            other disposition of such Collateral;  provided,  however,  that the
            Bank  shall have no duty to require  any money or  securities  to be
            delivered to it or to  determine  that the amount and form of assets
            delivered to it comply with any applicable requirements.  Collateral
            held in the  Special  Custody  Account  shall  be  released  only in
            accordance with this Agreement or as required by applicable law. The
            Customer  warrants  its  authority  to deposit in such  accounts any
            money securities and other property received by the Bank.

                  The  Bank  may  hold the  securities  in the  Special  Custody
            Account  in  bearer,  nominee,  book  entry,  or  other  form and in
            depository or clearing corporation,  with or without indicating that
            the  securities  are held  hereunder;  provided,  however,  that all
            securities  held in the Special  Custody Account shall be identified
            on the Bank's records as subject to this Agreement and shall be in a
            form that  permits  transfer  without  additional  authorization  or
            consent of the  Customer.  The Customer  and Broker  hereby agree to
            hold the Bank and its nominees harmless from any liability as holder
            of record.


      (b)   DIVIDENDS AND INTEREST.  Any dividends or interest paid with respect
            to the  Collateral  held in the  Special  Custody  Account  shall be
            retained therein as additional Collateral.

      (c)   REPORTS.  The Bank shall,  as promptly as practical,  provide Broker
            and the Customer  and/or  Customer's  designated  agent with written
            confirmation  of each transfer  into and out of the Special  Custody
            Account.  The Bank also shall render to Broker and  Customer  and/or
            Customers  designated  agent a monthly  statement of the  Collateral
            held in the Special  Custody  Account.  In  addition,  the Bank will
            advise Broker and Customer and/or  Customers  designated  agent upon
            request  at any time of the type and  amount of  Collateral  held in


                                       4
<PAGE>


            such  account;  provided,  however,  that  the  Bank  shall  have no
            responsibility  for making any determination as to the value of such
            Collateral.

      (d)   LIMITATION   OF   BANK'S   LIABILITY.    The   Bank's   duties   and
            responsibilities are as set forth in this Agreement.  The Bank shall
            act only upon  receipt of Advice  from Broker  regarding  release or
            substitution  of  Collateral.  The  Bank  shall  not  be  liable  or
            responsible  for anything done, or omitted to be done, by it in good
            faith and in the  absence  of  negligence  and may rely and shall be
            protected   in  acting  upon  any  notice,   instruction   or  other
            communication  which  it  reasonably  believes  to  be  genuine  and
            authorized.  As between the Bank and Broker,  Broker shall indemnify
            and hold the Bank harmless with regard to any losses or  liabilities
            of the Bank  (including  counsel fees) imposed on or incurred by the
            Bank arising out of any action or omission of the Bank in accordance
            with  any  Advice,  notice  or  Instruction  of  Broker  under  this
            Agreement. In matters concerning or relating to this Agreement,  the
            Bank  shall not be  responsible  for  compliance  with any status or
            regulation  regarding the  establishment  or  maintenance  of margin
            credit, including but not limited to Regulations T or X of the Board
            of Governors  of the Federal  Reserve  System,  or with any rules or
            regulations  of the Office of the Controller of the Currency (or the
            Securities and Exchange Commission). The Bank shall not be liable to
            any party for any acts or  omissions  of the other  parties  to this
            Agreement.

      (e)   Bank shall be paid as compensation for its services pursuant to this
            Agreement such  compensation as may from time to time be agreed upon
            in writing between Customer and Bank.

6.     DEFAULT
       -------

       In the  event of any  failure  by  Customer  to  timely  comply  with any
obligation on Customer's  part to be performed or observed  under this Agreement
or the Customer  Agreement,  including,  but not limited to, the  obligation  to
maintain Adequate Margin, or in the event of Customer's  Insolvency,  Broker has
the  right  to  give  notice  (which  notice  may  be  by  telegraph,  facsimile
transmission  or hand delivery) to Customer  specifying  such default and Broker
may,  after  giving such notice to  Customer,  effect a Closing  Transaction  or
buying of any securities of which Customer's  account may be short. In the event
of any default as aforesaid,  Broker shall also have the right, upon like notice
to Customer,  to sell any and all Collateral in the Special  Custody Account and
to give  Advice to Bank to deliver  such  Collateral  free of payment to Broker,
which  Advice  shall  state  that,  pursuant to this  Agreement,  the  condition
precedent  to  Brokers  right to receive  such  Collateral  free of payment  has
occurred.  The Bank will provide  immediate  telephone notice to Customer of any
receipt by Bank of Advice from Broker to deliver Collateral free of payment, and
shall promptly  effect  delivery of Collateral to Broker.  Such sale or purchase
may be made according to Broker's  judgment and at Broker's  discretion,  on the
principal  exchange or other  market for such  securities,  or in the event such
principal  market  is  closed,  in a  manner  commercially  reasonable  for such
securities.

7.    LIMITATION OF BROKER LIABILITY
      ------------------------------

      Broker  shall not be liable for any losses, costs, damages, liabilities or
expenses  suffered  or  incurred  by  Customer  as a result  of any  transaction
executed  hereunder,  or any other action taken or not taken by Broker hereunder
for  Customer's  account at  Customer's  direction or  otherwise,  except to the
extent  that such  loss,  cost,  damage,  liability  or expense is the result of
Broker's own recklessness, willful misconduct or bad faith.



                                       5
<PAGE>


8.    CUSTOMER REPRESENTATION
      -----------------------

      Customer  represents and warrants that the Collateral  will not be subject
to any other liens or encumbrances.

9.    TERMINATION
      -----------

      Any of the  parties  hereto  may  terminate  this  Agreement  by notice in
writing to the other parties hereto;  provided,  however, that the status of any
short sales,  and of  Collateral  held at the time of such notice to margin such
short sales shall be not affected by such termination  until the release of such
Collateral  pursuant  to  applicable  law,  regulations  or  rules  of any  self
regulatory  organization to which Broker is subject. In the event of the release
of Collateral,  the Collateral  shall be transferred to a proper custody account
of the Customer in the Bank.

10.   NOTICE
      ------

      Written communications  hereunder shall be telegraphed,  sent to facsimile
transmission  or hand  delivered  as required  herein,  when  another  method of
delivery is not  specified,  may be mailed first class postage  prepaid,  except
that written notice of termination shall be sent by certified mail, addressed:

      (a)   if to Bank, to:

            State Street Bank and Trust Company
            1776 Heritage Drive
            North Quincy, Massachusetts 02171
            Attn.: Christopher Meyers
            Telephone: 617-985-6345
            Telecopy: 617-537-6999

      (b)   if to Customer, to:

            INVESCO Funds Group, Inc.
            7800 E. Union Ave.
            Denver, Colorado 80237
            Attn.: Nancy Timm
            Telephone: 800-525-8085
            Telecopy: 303-930-6377

      (c)   if to Broker, to:

            Bear, Steams Securities Corp.
            245 Park Ave.
            New York, New York 10167
            Attn.: Michael Minikes, Treasurer
            Telephone: 212-272-2089
            Facsimile: 212-272-3099

11.   CONTROLLING LAW
      ---------------

      The construction and enforcement of this Agreement shall be subject to and
governed by the laws of the State of New York.


                                       6
<PAGE>


12.   THE AGREEMENT CONTROLS/AMENDMENTS
      ---------------------------------

       Customer and Bank agree that the terms of this Agreement shall supplement
and amend the Custody  Agreement  dated as of January 16, 1992  between the Bank
and the Customer with respect to the Special Custody Account,  and to the extent
inconsistent therewith,  the terms of this Agreement shall control. No amendment
of this  Agreement  shall be  effective  unless  in  writing  and  signed  by an
authorized officer of Broker, Customer and Bank.

       IN WITNESS WHEREOF,  the parties hereto have caused this instrument to be
executed  by their duly  authorized  officers as of the day and year first above
written.

STATE STREET BANK AND TRUST COMPANY

By:     /S/ Charles R. Whittemore Jr. 
        -----------------------------

Name:   Charles R. Whittemore Jr.

Title:  Vice President


INVESCO GLOBAL HEALTH SCIENCES FUND

By:     /S/  Dan J. Hesser
        ------------------

Name:   Dan J. Hesser

Title:  President


BEAR, STEARNS SECURITIES CORP .

By:     /S/  Michael Minikes 
        --------------------

Name:   Michael Minikes

Title:  Treasurer


                                       7




                        SPECIAL CUSTODY ACCOUNT AGREEMENT
                        ---------------------------------

                                  (Short Sales)


      AGREEMENT,  dated as of May 9, 1997,  by and among  State  Street Bank and
Trust Company, in its capacity as custodian  hereunder (the "Bank"),  The Global
Health Sciences Fund (the "Customer") and Herzog, Heine, Geduld, Inc.
(the "Broker").

      WHEREAS,  Broker  is a  securities  broker-dealer  and  is a  member  of
several national securities exchanges; and

      WHEREAS,  Customer  desires from time to time to sell  securities  "short"
through  Broker,  such short  sales being  permitted  by  Customer's  investment
policies,  and for that  purpose has  executed a margin  agreement  (the "Margin
Agreement"); and

      WHEREAS,  to  facilitate   Customer's   transactions  in  short  sales  of
securities,   Customer  and  Broker  desire  to  establish  procedures  for  the
compliance  by  Broker  with the  provisions  of  Regulation  T of the  Board of
Governors  of the  Federal  Reserve  System and other  applicable  law  ("Margin
Rules"); and

      WHEREAS, to assist Broker and Customer in complying with the Margin Rules,
Bank is prepared to act as custodian to hold Collateral as defined below.

      NOW, THEREFORE, be it agreed as follows:

1.    DEFINITIONS
      -----------

      As used herein, the following terms have the following meanings:

     (a)  "Adequate Margin" in respect of short sales shall mean such Collateral
          as is adequate in Broker's  reasonable judgment under the Margin Rules
          and the internal policies of Broker.

     (b)  "Advice  from  Broker"  or  "Advice"  means a written  notice  sent to
          Customer and Bank or transmitted by a facsimile sending device, except
          that Advices for initial or  additional  Collateral or with respect to
          Broker's  ability  to effect a short  sale for  Customer  may be given
          orally.  With  respect to any short sale or Closing  Transaction,  the
          Advice from Broker shall mean a standard confirmation in use by Broker
          and  sent or  transmitted  to  Customer  and  Bank.  With  respect  to
          substitutions  or releases of  Collateral,  Advice from Broker means a
          written  notice signed by Broker and sent or  transmitted  to Customer
          and Bank. An  authorized  agent of Broker will certify to Customer and

<PAGE>

          Bank the names and signatures of those employees who are authorized to
          sign Advices from Broker, which certification may be amended from time
          to time. When used herein,  the term "Advise" means the act of sending
          an Advice from Broker.

     (c)  "Closing  Transaction"  is a transaction in which  Customer  purchases
          securities which have been sold short.

     (d)  "Collateral"  shall mean cash or U.S.  Government  securities or other
          securities acceptable to Broker.

     (e)  "Insolvency"  means  that (A) an order,  judgment  or decree  has been
          entered under the bankruptcy, reorganization, compromise, arrangement,
          insolvency,  readjustment  of  debt,  dissolution  or  liquidation  or
          similar law (herein called the "Bankruptcy  Law") of any  jurisdiction
          adjudicating  the  Customer   insolvent;   or  (B)  the  Customer  has
          petitioned  or  applied  to any  tribunal  for,  or  consented  to the
          appointment  of,  or  taking  possession  by,  a  trustee,   receiver,
          liquidator  or similar  official,  of the  Customer,  or  commenced  a
          voluntary  case under the  Bankruptcy  Law of the United States or any
          proceedings  relating to the Customer  under the Bankruptcy Law of any
          other  jurisdiction,  whether now or hereinafter in effect; or (C) any
          such petition or application has been filed,  or any such  proceedings
          commenced,  against  the  Customer  and  the  Customer  by any act has
          indicated  its  approval  thereof,  consent  thereto  or  acquiescence
          therein,  or an order for  relief has been  entered in an  involuntary
          case  under  the  Bankruptcy  Law  of  the  United  States,  as now or
          hereinafter  constituted,  or any order,  judgment  or decree has been
          entered  appointing  any such trust,  receiver,  liquidator or similar
          official, or approving the petition in any such proceedings,  and such
          order, judgment or decree remains unstayed and in effect for more than
          60 days.

     (f)  "Instructions  from  Customer"  or  "Instructions"  means  a  request,
          direction or certification in writing signed by Customer and delivered
          to Bank and Broker or transmitted by a facsimile  sending  device.  An
          officer  of  Customer  will  certify  to Bank and Broker the names and
          signatures of those persons authorized to sign the instructions, which
          certification may be amended from time to time. When used herein,  the
          term  "Instruct"  shall mean the act of sending  an  Instruction  from
          Customer.

     (g)  "Receipt  of  Payment"  means  receipt by Bank of (1) a  certified  or
          official  bank  check or wire  transfer  to  Bank;  (2) a  written  or
          telegraphic  advice from a registered  clearing agency that funds have
          been or will be credited to the account of Bank,  or (3) a transfer of
          funds from any of Broker's accounts maintained at Bank.

     (h)  "Receipt of  Securities"  means receipt by Bank, of (1)  securities in
          proper form for transfer or (2) a written or telegraphic advice from a

                                      -2-
<PAGE>

          registered  clearing  agency that securities have been credited to the
          account of Bank for the Special Custody Account.

     (i)  "Special Custody Account" shall have the meaning assigned to that term
          in Section 2 hereof.

2.   SPECIAL CUSTODY ACCOUNT
     -----------------------

     (a)  Bank  shall open an account  on its books  entitled  "Special  Custody
          Account  for  Herzog,  Heine,  Geduld,  Inc.  as Pledgee of The Global
          Health  Sciences  Fund"  ("Special  Custody  Account")  and shall hold
          therein all securities  and similar  property as shall be received and
          accepted by it therein pursuant to this Agreement.  Customer agrees to
          instruct  Bank in  Instructions  from Customer as to cash and specific
          securities  which  Bank is to  identify  on its books and  records  as
          pledged  to Broker  as  Collateral  in the  Special  Custody  Account.
          Customer agrees that the value of such cash and securities shall be at
          least equal in value to what Broker shall  initially  and from time to
          time  advise  Customer  in an  Advice  from  Broker  is  necessary  to
          constitute  Adequate Margin.  Such collateral (i) will be held by Bank
          for Broker as agent of Broker, (ii) may be released only in accordance
          with the terms of this  Agreement  and (iii)  except as required to be
          released hereunder to Broker, shall not be made available to Broker or
          to any other person claiming  through Broker,  including the creditors
          of the Broker.

     (b)  Customer hereby grants a continuing security interest to Broker in the
          Collateral  in  the  Special  Custody  Account.  To  perfect  Broker's
          security  interest,  Bank  will  hold the  Collateral  in the  Special
          Custody  Account,  subject  to the  interest  therein of Broker as the
          pledgee and secured party thereof in accordance with the terms of this
          Agreement.  Such  security  interest  will  terminate  at such time as
          Collateral  is  released  as  provided  herein.  Bank  shall  have  no
          responsibility  for the validity or  enforceability  of such  security
          interest.

     (c)  Bank will  confirm  in writing to Broker  and  Customer  all  pledges,
          releases or  substitutions  of  Collateral  and will supply Broker and
          Customer with a monthly statement of Collateral and transaction in the
          Special Custody  Account for such month.  Bank will also advise Broker
          upon request of the kind and amount of Collateral pledged to Broker.

     (d)  Upon the request of Customer, Broker shall advise Bank and Customer of
          any excess of Collateral in the Special Custody  Account.  Such excess
          shall at Customer's request be transferred  therefrom upon Advice from
          Broker.  Customer  represents  and warrants to Broker that  securities
          included at any time in the  Collateral  shall be in good  deliverable
          form (or Bank shall have the unrestricted power to put such securities
          into good  deliverable  form) in accordance  with the  requirements of

                                      -3-
<PAGE>

          such  exchanges  as may be the  primary  market  or  markets  for such
          securities.

     (e)  Bank will  maintain  accounts  and records for the  Collateral  in the
          Special Custody  Account as more fully described in subparagraph  5(a)
          below.  The  Collateral  shall at all times remain the property of the
          Customer subject only to the extent of the interest and rights therein
          of Broker as the pledgee thereof.

3.   ORIGINAL AND VARIATION MARGIN ON SHORT SALES
     --------------------------------------------

     (a)  From time to time, Customer may place orders with Broker for the short
          sale of securities. Prior to the acceptance of such orders Broker will
          advise Customer of Broker's ability to borrow such securities or other
          properties and acceptance of short sale orders will be contingent upon
          same.

     (b)  Broker  shall,  on the last  business  day of each week,  compute  the
          aggregate net credit or debit  balance on Customer's  open short sales
          and advise  Customer by 11:00 A.M.  New York time of the amount of the
          net debit or credit, as the case may be. If a net debit balance exists
          on such day,  Customer  will  cause an amount  equal to such net debit
          balance to be paid to Broker by the close of  business on such day. If
          a net credit balance  exists on such day,  Broker will pay such credit
          balance  to  Customer  by the  close  of  business  on  such  day.  As
          Customer's  open  short  positions  are  marked-to-market  each  week,
          payments will be made by or to Customer to reflect changes (if any) in
          the credit or debit  balances.  Broker will  charge  interest on debit
          balances,  and Broker will pay interest on credit  balances.  Balances
          will be appropriately adjusted when short sales are closed out.

4.   PLACING ORDER
     -------------

      It is understood  and agreed that  Customer,  when placing with Broker any
order to sell short for Customer's account, will designate the order as such and
hereby authorizes  Broker to mark such order as being "short",  and when placing
with Broker any order to sell long for  Customer's  account,  will designate the
order as such and hereby  authorizes  Broker to mark such order as being "long".
Any sell order which Customer shall designate as being for long account as above
provided is for  securities  then owned by Customer and, if such  securities are
not then deliverable by Broker from any account of Customer, the placing of such
order shall constitute a representation by Customer that it is impracticable for
Customer  then to deliver  such  securities  to Broker but that  Customer  shall
deliver them by the settlement date or as soon as possible thereafter.

5.   RIGHTS AND DUTIES OF THE BANK
     -----------------------------

     (a)  GENERALLY.  The Bank shall  receive  and hold in the  Special  Custody
          Account, as custodian upon the terms of this Agreement, all Collateral
          deposited and maintained  pursuant to the terms of this Agreement and,
          except as provided in subparagraph 5(b) below,  shall receive and hold

                                      -4-
<PAGE>

          all monies and other  property  paid,  distributed  or  substituted in
          respect  of  such   Collateral  or  realized  on  the  sale  or  other
          disposition of such Collateral; provided, however, that the Bank shall
          have no duty to require any money or  securities to be delivered to it
          or to  determine  that the amount and form of assets  delivered  to it
          comply  with  any  applicable  requirements.  Collateral  held  in the
          Special Custody Account shall be released only in accordance with this
          Agreement or as required by applicable law. The Customer  warrants its
          authority to deposit in such accounts any money,  securities and other
          property received by the Bank.

                The  Bank  may  hold the  securities  in the  Special  Custody
          Account  in  bearer,  nominee,  book  entry,  or  other  form and in
          depository or clearing corporation,  with or without indicating that
          the  securities  are held  hereunder;  provided,  however,  that all
          securities  held in the Special  Custody Account shall be identified
          on the Bank's records as subject to this Agreement and shall be in a
          form that  permits  transfer  without  additional  authorization  or
          consent of the  Customer.  The Customer  and Broker  hereby agree to
          hold the Bank and its nominees harmless from any liability as holder
          of record.

     (b)  DIVIDENDS AND INTEREST. Any dividends or interest paid with respect to
          the Collateral  held in the Special  Custody  Account shall be paid by
          the Bank to the Customer when  collected  unless the Bank has received
          contrary instructions from the Customer.

     (c)  REPORTS. The Bank shall, as promptly as practical,  provide Broker and
          the Customer with written  confirmation  of each transfer into and out
          of the  Special  Custody  Account.  The Bank also shall  render to the
          Customer and Broker a monthly  statement of the Collateral held in the
          Special  Custody  Account.  In  addition,  the Bank  will  advise  the
          Customer or Broker upon  request at any time of the type and amount of
          Collateral held in the account; provided, however, that the Bank shall
          have no responsibility for making any determination as to the value of
          such Collateral.

     (d)  LIMITATION OF BANK'S LIABILITY. The Bank's duties and responsibilities
          are as set  forth in this  Agreement.  The Bank  shall  act only  upon
          receipt of Advice from Broker  regarding  release of  Collateral.  The
          Bank shall not be liable or responsible  for anything done, or omitted
          to be done by it in good faith and in the  absence of  negligence  and
          may rely and shall be protected in acting upon any notice, instruction
          or other  communication which it reasonably believes to be genuine and
          authorized.  As  between  Customer  and the  Bank,  the  terms  of the
          Custodian  Agreement  shall  apply  with  respect  to  any  losses  or
          liabilities  of such  parties  arising out of matters  covered by this
          Agreement.  As between the Bank and Broker, Broker shall indemnify and
          hold the Bank harmless with regard to any losses or liabilities of the
          Bank  (including  counsel  fees)  imposed on or  incurred  by the Bank

                                      -5-
<PAGE>

          arising out of any action or omission of the Bank in  accordance  with
          any notice or instruction of Broker under this  Agreement.  In matters
          concerning  or  relating  to this  Agreement,  the Bank  shall  not be
          responsible  for compliance  with any statute or regulation  regarding
          the  establishment or maintenance of margin credit,  including but not
          limited to Regulations T or X of the Board of Governors of the Federal
          Reserve System,  or with any rules or regulations of the OCC. The Bank
          shall not be liable  to any  party  for any acts or  omissions  of the
          other parties to this Agreement.

     (e)  Bank shall be paid as compensation  for its services  pursuant to this
          Agreement such compensation as may from time to time be agreed upon in
          writing between Customer and Bank.

6.    DEFAULT
      -------

      In the event of a default by Customer of its  obligations  (i) to maintain
Adequate Margin as herein provided, (ii) to timely comply with any obligation on
Customer's  part to be  performed  or observed  under this  Agreement  or in the
Margin  Agreement,  (iii) to pay on demand by Broker  any  losses  sustained  by
Broker as may occur under  circumstances  contemplated  in paragraph 3 above; or
(iv) in the event of Customer's Insolvency,  Broker has the right to give notice
(which notice may be by telegraph,  facsimile  transmission or hand delivery) to
Customer  specifying  such default and Broker may, no sooner than 2:00 P.M., New
York time on the next  business  day after  giving such notice to  Customer,  if
Customer  continues  to be in default or  insolvent  at the end of such  period,
effect a Closing  Transaction  or buy-in of any  securities of which  Customer's
account may be short. In the event of a default specified in subparagraphs  (i),
(ii) or (iii)  above,  Broker  shall also have the right,  upon like  notice and
grace period,  to sell any and all Collateral in the Special Custody Account and
to give  Advice to Bank to deliver  such  Collateral  free of payment to Broker,
which  Advice  shall  state  that,  pursuant to this  Agreement,  the  condition
precedent  to Broker' s right to receive  such  Collateral  free of payment  has
occurred.  The Bank will  provide  prompt  telephone  notice to  Customer of any
receipt by Bank of Advice from Broker to deliver Collateral free of payment, and
shall effect delivery of Collateral to Broker. Such sale or purchase may be made
according to Broker's  judgment and may be made at Broker's  discretion,  on the
principal  exchange or other  market for such  securities,  or in the event such
principal  market  is  closed,  in a  manner  commercially  reasonable  for such
securities.

7.    LIMITATION OF BROKER LIABILITY
      ------------------------------

      Broker shall not be liable for any losses, costs, damages,  liabilities or
expenses  suffered  or  incurred  by  Customer  as a result  of any  transaction
executed  hereunder,  or any other action taken or not taken by Broker hereunder
for  Customer's  account at  Customer's  direction or  otherwise,  except to the
extent  that such  loss,  cost,  damage,  liability  or expense is the result of
Broker's own recklessness, willful misconduct or bad faith.


                                      -6-
<PAGE>


8.    CUSTOMER REPRESENTATION
      -----------------------

      Customer  represents and warrants that the Collateral  will not be subject
to any other liens or encumbrances.

9.    TERMINATION
      -----------

      Any of the  parties  hereto  may  terminate  this  Agreement  by notice in
writing to the other parties hereto;  provided,  however, that the status of any
short sales,  and of  Collateral  held at the time of such notice to margin such
short sales shall not be affected by such termination  until the release of such
Collateral pursuant to applicable rules of such national securities exchanges of
which  Broker may be a member.  In the event of the release of  Collateral,  the
Collateral shall be transferred to Customer.

10.   NOTICE
      ------

      Written communications  hereunder shall be telegraphed,  sent by facsimile
transmission  or hand  delivered  as required  herein,  when  another  method of
delivery is not  specified,  may be mailed first class postage  prepaid,  except
that written notice of termination shall be sent by certified mail, addressed:

      (a)   if to Bank, to:

            State Street Bank and Trust Company
            1776 Heritage Drive
            North Quincy, Massachusetts 02171
            Attn: Christopher Meyers
            Telephone: 617-985-6345
            Telecopy: 617-537-6999


      (b)   if to Customer, to:

            INVESCO Funds Group, Inc.
            7800 E. Union Avenue
            Denver, Colorado 80237
            Attn: Glen A. Payne
            Telephone: 303-930-6300
            Telecopy: 303-930-6307


                                      -7-
<PAGE>


      (c)   if to Broker, to:

            Herzog, Heine, Geduld, Inc.
            525 Washington Blvd.
            Jersey City, NJ 07310
            Attn: Frank Jaeger
            Telephone: 201-418-5175
            Telecopy: 201-418-5224

11.   CONTROLLING LAW
      ---------------

      The construction and enforcement of this Agreement shall be subject to and
governed by the laws of the Commonwealth of Massachusetts.

















                                      -8-
<PAGE>


IN WITNESS  WHEREOF,  each of the  undersigned  has caused the  Agreement  to be
executed in its name and on its behalf by a duly authorized representative as of
the aforementioned day and year.


STATE STREET BANK AND TRUST COMPANY


By:   /s/ Charles R. Whittemore, Jr. 
      -----------------------------------
Title:      Vice President
      -----------------------------------


THE GLOBAL HEALTH SCIENCES FUND


By:   /s/ Glen A. Payne                   
      -----------------------------------
Title:      Secretary
      -----------------------------------


HERZOG, HEINE, GEDULD, INC.


By:   /s/ Frank Jaeger                    
      -----------------------------------
Title:      Executive Vice President
      -----------------------------------






                                      -9-


















                                   REGISTRAR,
                      TRANSFER AGENCY AND SERVICE AGREEMENT

                                     between

                         THE GLOBAL HEALTH SCIENCES FUND

                                       and

                       STATE STREET BANK AND TRUST COMPANY





















<PAGE>


                                TABLE OF CONTENTS
                                -----------------

                                                                            PAGE
                                                                            ----

Article 1        Terms of Appointment; Duties of the Bank. . . . . . . . . . . 1

Article 2        Fees and Expenses . . . . . . . . . . . . . . . . . . . . . . 3

Article 3        Representations and Warranties of the Bank. . . . . . . . . . 3

Article 4        Representations and Warranties of the Fund. . . . . . . . . . 4

Article 5        Indemnification . . . . . . . . . . . . . . . . . . . . . . . 4

Article 6        Covenants of the Fund and the Bank. . . . . . . . . . . . . . 7

Article 7        Termination of Agreement. . . . . . . . . . . . . . . . . . . 8

Article 8        Assignment. . . . . . . . . . . . . . . . . . . . . . . . . . 8

Article 9        Amendment . . . . . . . . . . . . . . . . . . . . . . . . . . 9

Article 10       Massachusetts Law to Apply. . . . . . . . . . . . . . . . . . 9

Article 11       Merger of Agreement . . . . . . . . . . . . . . . . . . . . . 9

Article 12       Limitations of Liability of the Trustees
                  and Shareholders . . . . . . . . . . . . . . . . . . . . . . 9


                                       2
<PAGE>

               REGISTRAR, TRANSFER AGENCY AND SERVICE AGREEMENT
               ------------------------------------------------

        AGREEMENT made as of the 16th day of January, 1992, by and between THE
GLOBAL HEALTH SCIENCES FUND, a Massachusetts business trust, having its
principal office and place of business at 7800 E. Union Avenue, Denver, Colorado
80237, (the "Fund"), and STATE STREET BANK AND TRUST COMPANY, a Massachusetts
trust company having its principal office and place of business at 225 Franklin
Street, Boston, Massachusetts 02110 (the "Bank").

        WHEREAS, the Fund desires to appoint the Bank as its registrar, transfer
agent, dividend disbursing agent, custodian of certain retirement plans and
agent in connection with certain other activities and the Bank desires to accept
such appointment;

        NOW, THEREFORE, in consideration of the mutual covenants herein
contained, the parties hereto agree as follows:

Article 1      TERMS OF APPOINTMENT; DUTIES OF THE BANK
               ----------------------------------------

               1.01  Subject to the terms and conditions set forth in this
Agreement, the Fund hereby employs and appoints the Bank to act as, and the Bank
agrees to act as registrar, transfer agent for the Fund's authorized and issued
shares of its common stock ("Shares"), dividend disbursing agent, custodian of
certain retirement plans and agent in connection with any dividend reinvestment
plan as set out in the prospectus of the Fund, corresponding to the date of this
Agreement.

               1.02 The Bank agrees that it will perform the following services:


                                       3
<PAGE>

               (a) In accordance with procedures established from time to time
by agreement between the Fund and the Bank, the Bank shall:

                    (i)   Issue and record the appropriate number of Shares as
                          authorized and hold such Shares in the appropriate
                          Shareholder account;

                   (ii)   Effect transfers of Shares by the registered owners
                          thereof upon receipt of appropriate documentation;

                  (iii)   Execute transactions directly with broker-dealers
                          authorized by the Fund who shall thereby be deemed to
                          be acting on behalf of the Fund;

                   (iv)   Prepare and transmit payments for dividends and
                          distributions declared by the Fund;

                    (v)   Act as agent for Shareholders pursuant to the dividend
                          reinvestment and cash purchase plan as amended from
                          time to time in accordance with the terms of the
                          agreement to be entered into between the Shareholders
                          and the Bank in substantially the form attached as
                          Exhibit A hereto;

                   (vi)   Issue replacement certificates for those
                          certificates alleged to have been lost, stolen or
                          destroyed upon receipt by the Bank of
                          indemnification satisfactory to the Bank and
                          protecting the Bank and the Fund, and the Bank at


                                       4
<PAGE>

                          its option, may issue replacement certificates in
                          place of mutilated stock certificates upon
                          presentation thereof and without such indemnity; and

                  (vii)   Report abandoned property to the various states as
                          authorized by the Fund per policies and principles
                          agreed upon by the Fund and the Bank.

               (b) In addition to and neither in lieu nor in contravention of
the services set forth in the above paragraph (a), the Bank shall: (i) perform
all of the customary services of a registrar, transfer agent, dividend
disbursing agent, custodian of certain retirement plans and agent of the
dividend reinvestment and cash purchase plan as described in Article 1
consistent with those requirements in effect as at the date of this Agreement.
The detailed definition, frequency, limitations and associated costs (if any)
set out in the attached fee schedule, include but not limited to: maintaining
all Shareholder accounts, preparing Shareholder meeting lists, mailing proxies,
receiving and tabulating proxies and mailing Shareholder reports to current
Shareholders, withholding taxes on U.S. resident and non-resident alien accounts
where applicable, preparing and filing U.S. Treasury Department Forms 1099 and
other appropriate forms required with respect to dividends and distributions by
federal authorities for all registered Shareholders.

Article 2      FEES AND EXPENSES
               -----------------

               2.01  For the performance by the Bank pursuant to this Agreement,
the Fund agrees to pay the Bank an annual maintenance fee as set out in the
initial fee schedule attached hereto. Such fees and out-of-pocket expenses and


                                       5
<PAGE>

advances identified under Section 2.02 below may be changed from time to time
subject to mutual written agreement between the Fund and the Bank.

               2.02  In addition to the fee paid under Section 2.01 above, the
Fund agrees to reimburse the Bank for out-of-pocket expenses or advances
incurred by the Bank for the items set out in the fee schedule attached hereto.
In addition, any other expenses incurred by the Bank at the request or with the
consent of the Fund, will be reimbursed by the Fund.

               2.03  The Fund agrees to pay all fees and reimbursable expenses
within five days following the receipt of the respective billing notice. Postage
and the cost of materials for mailing of dividends, proxies, Fund reports and
other mailings to all Shareholder accounts shall be advanced to the Bank by the
Fund at least seven (7) days prior to the mailing date of such materials.

Article 3      REPRESENTATIONS AND WARRANTIES OF THE BANK
               ------------------------------------------

               The Bank represents and warrants to the Fund that:

               3.01  It is a trust company duly organized and existing and
in good standing under the laws of the Commonwealth of Massachusetts.

               3.02  It is duly qualified to carry on its business in the
Commonwealth of Massachusetts.

               3.03  It is empowered under applicable laws and by its Charter
and By-Laws to enter into and perform this Agreement.

               3.04  All requisite corporate proceedings have been taken to
authorize it to enter into and perform this Agreement.


                                       6
<PAGE>

               3.05  It has and will continue to have access to the necessary
facilities, equipment and personnel to perform its duties and obligations under
this Agreement.

Article 4      REPRESENTATIONS AND WARRANTIES OF THE FUND
               ------------------------------------------

               The Fund represents and warrants to the Bank that:

               4.01  It is a business trust duly organized and existing
and in good standing under the laws of Massachusetts.

               4.02  It is empowered under applicable laws and by its
Declaration of Trust and By-Laws to enter into and perform this Agreement.

               4.03  All corporate proceedings required by said
Declaration of Trust and By-Laws have been taken to authorize it to enter into
and perform this Agreement.

               4.04  It is a closed-end, diversified investment company
registered under the Investment Company Act of 1940, as amended.

               4.05  To the extent required by federal securities laws a
registration statement under the Securities Act of 1933, as amended is currently
effective and appropriate state securities law filings have been made with
respect to all Shares of the Fund being offered for sale; information to the
contrary will result in immediate notification to the Bank.

               4.06  It shall make all required filings under federal and
state securities laws.

Article 5      INDEMNIFICATION
               ---------------

               5.01  The Bank shall not be responsible for, and the Fund shall
indemnify and hold the Bank harmless from and against, any and all losses,


                                       7
<PAGE>

damages, costs, charges, counsel fees, payments, expenses and liability arising
out of or attributable to:

               (a) All actions of the Bank or its agents or subcontractors
required to be taken pursuant to this Agreement, provided that such actions are
taken in good faith and without negligence or willful misconduct.

               (b) The Fund's lack of good faith, negligence or willful
misconduct which arise out of the breach of any representation or warranty of
the Fund hereunder.

               (c) The reliance on or use by the Bank or its agents or
subcontractors of information, records and documents which (i) are received or
relied upon by the Bank or its agents or subcontractors and/or furnished to it
or performed by or on behalf of the Fund, and (ii) have been prepared,
maintained and/or performed by the Fund or any other person or firm on behalf of
the Fund.

               (d) The reliance on, or the carrying out by the Bank or its
agents or subcontractors of any instructions or requests of the Fund.

               (e) The offer or sale of Shares in violation of any requirement
under the federal securities laws or regulations or the securities laws or
regulations of any state that such Shares be registered in such state or in
violation of any stop order or other determination or ruling by any federal
agency or any state with respect to the offer or sale of such Shares in such
state.

               5.02 The Bank shall indemnify and hold the Fund harmless from and
against any and all losses, damages, costs, charges, counsel fees, payments,
expenses and liability arising out of or attributable to any action or failure


                                       8
<PAGE>

or omission to act by the Bank as a result of the Bank's lack of good faith,
negligence or willful misconduct.

               5.03  At any time the Bank may apply to any officer of the Fund
for instructions, and may consult with legal counsel with respect to any matter
arising in connection with the services to be performed by the Bank under this
Agreement, and the Bank and its agents or subcontractors shall not be liable and
shall be indemnified by the Fund for any action taken or omitted by it in
reliance upon such instructions or upon the opinion of such counsel. The Bank,
its agents and subcontractors shall be protected and indemnified in acting upon
any paper or document furnished by or on behalf of the Fund, reasonably believed
to be genuine and to have been signed by the proper person or persons, or upon
any instruction, information, data, records or documents provided the Bank or
its agents or subcontractors by telephone, in person, machine readable input,
telex, CRT data entry or other similar means authorized by the Fund, and shall
not be held to have notice of any change of authority of any person, until
receipt of written notice thereof from the Fund. The Bank, its agents and
subcontractors shall also be protected and indemnified in recognizing stock
certificates which are reasonably believed to bear the proper manual or
facsimile signatures of the officers of the Fund, and the proper
countersignature of any former transfer agent or former registrar, or of a
co-transfer agent or co-registrar.

               5.04  In the event either party is unable to perform its
obligations under the terms of this Agreement because of acts of God, strikes,
equipment or transmission failure or damage reasonably beyond its control, or


                                       9
<PAGE>

other causes reasonably beyond its control, such party shall not be liable for
damages to the other for any damages resulting from such failure to perform or
otherwise from such causes.

               5.05  Neither party  to this  Agreement shall be liable to the
other party for consequential damages under any provision of this Agreement or
for any consequential damages arising out of any act or failure to act 
hereunder.

               5.06  In order that the indemnification provisions contained in
this Article 5 shall apply, upon the assertion of a claim for which either party
may be required to indemnify the other, the party seeking indemnification shall
promptly notify the other party of such assertion, and shall keep the other
party advised with respect to all developments concerning such claim. The party
who may be required to indemnify shall have the option to participate with the
party seeking indemnification in the defense of such claim. The party seeking
indemnification shall in no case confess any claim or make any compromise in any
case in which the other party may be required to indemnify it except with the
other party's prior written consent.

Article 6      COVENANTS OF THE FUND AND THE BANK
               ----------------------------------

               6.01  The Fund shall promptly furnish to the Bank the following:

               (a)   A certified copy of the resolution of the Board of Trustees
of the Fund authorizing the appointment of the Bank and the execution and
delivery of this Agreement.

               (b)   A copy of the Declaration of Trust and By-Laws of the Fund
and all amendments thereto.


                                       10
<PAGE>

               6.02  The Bank hereby agrees to establish and maintain facilities
and procedures reasonably acceptable to the Fund for safekeeping of stock
certificates, check forms and facsimile signature imprinting devices, if any;
and for the preparation or use, and for keeping account of, such certificates,
forms and devices.

               6.03  The Bank shall keep records relating to the services to be
performed hereunder, in the form and manner as it may deem advisable. To the
extent required by Section 31 of the Investment Company Act of 1940, as amended,
and the Rules thereunder, the Bank agrees that all such records prepared or
maintained by the Bank relating to the services to be performed by the Bank
hereunder are the property of the Fund and will be preserved, maintained and
made available in accordance with such Section and Rules, and will be
surrendered promptly to the Fund on and in accordance with its request.

               6.04  The Bank and the Fund agree that all books, records,
information and data pertaining to the business of the other party which are
exchanged or received pursuant to the negotiation or the carrying out of this
Agreement shall remain confidential, and shall not be voluntarily disclosed to
any other person, except as may be required by law.

               6.05  In cases of any requests or demands for the inspection of
the Shareholder records of the Fund, the Bank will endeavor to notify the Fund
and to secure instructions from an authorized officer of the Fund as to such
inspection. The Bank reserves the right, however, to exhibit the Shareholder
records to any person whenever it is advised by its counsel that it may be held



                                       11
<PAGE>

liable for the failure to exhibit the Shareholder records to such person.

Article 7      TERMINATION OF AGREEMENT
               ------------------------

               7.01  This Agreement may be terminated by either party upon one
hundred twenty (120) days written notice to the other.

               7.02  Should the Fund exercise its right to terminate, all
out-of-pocket expenses associated with the movement of records and material will
be borne by the Fund. Additionally, the Bank reserves the right to charge for
any other reasonable expenses associated with such termination and/or a charge
equivalent to the average of three (3) month's fees.

Article 8      ASSIGNMENT
               ----------

               8.01  Except as provided in Section 8.03 below, neither this
Agreement nor any rights or obligations hereunder may be assigned by either
party without the written consent of the other party.

               8.02  This Agreement shall inure to the benefit of and be binding
upon the parties and their respective permitted successors and assigns.

               8.03  The Bank may, without further consent on the part of the
Fund, subcontract for the performance hereof with (i) Boston Financial Data
Services, Inc., a Massachusetts corporation ("BFDS") which is duly registered as
a transfer agent pursuant to Section 17A(c)(1) of the Securities Exchange Act of
1934, as amended ("Section 17A(c)(1)"), (ii) a BFDS subsidiary duly registered
as a transfer agent pursuant to Section 17A(c)(1) or (iii) a BFDS affiliate;
provided, however, that the Bank shall be as fully responsible to the Fund for


                                       12
<PAGE>

the acts and omissions of any subcontractor as it is for its own acts and
omissions.

Article 9      AMENDMENT
               ---------

               9.01  This Agreement may be amended or modified by a
written agreement executed by both parties and authorized or approved by a
resolution of the Board of Trustees of the Fund.

Article 10     MASSACHUSETTS LAW TO APPLY
               --------------------------

               10.01 This Agreement shall be construed and the provisions
thereof interpreted under and in accordance with the laws of the Commonwealth
of Massachusetts.

Article 11     MERGER OF AGREEMENT
               -------------------

               11.01 This Agreement constitutes the entire agreement between the
parties hereto and supersedes any prior agreement with respect to the subject
hereof whether oral or written.

Article 12     LIMITATIONS OF LIABILITY OF THE TRUSTEES AND SHAREHOLDERS
               ---------------------------------------------------------

               12.01 A copy of the Declaration of Trust of the Trust is on
file with the Secretary of the Commonwealth of Massachusetts, and notice is
hereby given that this instrument is executed on behalf of the Trustees of the
Trust as Trustees and not individually and that the obligations of this
instrument are not binding upon any of the Trustees or Shareholders individually
but are binding only upon the assets and property of the Fund.


                                       13
<PAGE>

      IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed in their names and on their behalf by and through their duly authorized
officers, as of the day and year first above written.


                              THE GLOBAL HEALTH SCIENCES FUND


                              BY: /s/ John J. Kaweske
                                  ----------------------


ATTEST:

/s/ Glen A. Payne
- -------------------------



                              STATE STREET BANK AND TRUST COMPANY


                              BY: /s/ Charles N. Whittemore, Jr.
                                  -------------------------------
                                          Vice President

ATTEST:

/s/ Maureen A. Rodriguez
- ---------------------------------
Assistant Secretary



                            ADMINISTRATION AGREEMENT

      Agreement made as of February 28, 1997, between THE GLOBAL HEALTH SCIENCES
FUND, a Massachusetts  business trust ("Fund"), and INVESCO FUNDS GROUP, INC., a
Delaware corporation ("INVESCO").

      WHEREAS, the Fund operates as a closed end management  investment company,
and is so registered under the Investment Company Act of 1940, as amended ("1940
Act"); and

      WHEREAS,   the  Fund   wishes  to  retain   INVESCO  to  provide   certain
administrative  services  to the Fund,  under the  terms and  conditions  stated
below,  and INVESCO is willing to provide such services for the compensation set
forth below;

      NOW,  THEREFORE,  in  consideration  of the premises and mutual  covenants
 contained herein, the parties agree as follows:

1.    APPOINTMENT.  The Fund hereby  appoints  INVESCO as  administrator  of the
      Fund, and INVESCO accepts such appointment and agrees that it will furnish
      the services set forth in paragraph 2 below.

2.    SERVICES AND DUTIES OF INVESCO TO THE FUND.  Subject to the supervision of
      the Fund's Board of Trustees ("Board"), INVESCO will:

      (a)   Prepare the Fund's financial reports for reporting to the SEC, NYSE,
            shareholders and other appropriate parties;

      (b)   Provide   appropriate   financial   information  to  outside  survey
            organizations,   the  Board,   senior  Fund  management,   portfolio
            management, and others;

      (c)   Prepare and file all SEC required filings, including but not limited
            to Form NSAR and Form N2, if necessary;

      (d)   Prepare the Fund's  annual tax  provision,  and prepare and file the
            Fund's federal, excise, state and local tax returns;

<PAGE>


      (e)   Determine the Fund's  dividends and total  distributions  to be made
            available to  shareholders  in accordance  with the Fund's  Dividend
            Reimbursement Plan. Coordinate with the Fund's transfer and dividend
            disbursing agent and custodian for payment of such distributions;

      (f)   Monitor the Fund' s compliance in accordance  with the  requirements
            of the 1940 Act, the Internal Revenue Code, the investment objective
            and  restrictions of the Fund, the derivatives  policy as adopted by
            the Board, and attend to other compliance  matters,  as appropriate.
            Assist the portfolio managers in compliance matters when necessary;

      (g)   In accordance with the annual Quality Control Plan,  perform reviews
            and testing of the Fund to ensure that  transaction  and  processing
            controls  are  operating  reliably.  Bring to the  attention of Fund
            management all appropriate matters;

      (h)   Assist the  independent  auditors  or other  regulatory  agencies in
            their examinations of the Fund;

      (i)   Coordinate  and  disburse to outside  parties any  payments or items
            requiring remittance on behalf of the Fund;

      (j)   Negotiate  and  monitor  contractual  arrangements  with the  Fund's
            agents,  including its custodian,  transfer  agent,  and independent
            accountant. Report to the Board on an annual basis, or as necessary,
            regarding performance and recommendations of such agents;

      (k)   Monitor the accounting policies of the Fund;

      (1)   Prepare  and review the  calculation  of the Net Asset  Value of the
            Fund in  accordance  with the  requirements  of the 1940 Act and the
            Securities  Act of 1933,  as amended.  Report the Net asset Value to
            all appropriate entities, including the New York Stock Exchange; and

      (m)   Create and maintain the records of the Fund in accordance  with Rule
            31a1 of the 1940 Act.

3.    PUBLIC  INQUIRIES.  The Fund and INVESCO agree that while INVESCO will not
      have any  obligation  to reply to questions  or requests  for  information
      concerning  the  Fund  from  shareholders,  brokers  or the  public,  such
      services  will be provided to the Fund by INVESCO  Trust Company under the
      Investment Advisory  Agreement.  The Fund will inform INVESCO of the party
      or parties to whom any such questions or requests should be directed,  and
      INVESCO will refer such questions and requests to such party or parties.



                                       2
<PAGE>


4.    COMPLIANCE WITH THE FUND'S GOVERNING  DOCUMENTS AND APPLICABLE LAW. In all
      matters relating to the performance of this Agreement, INVESCO will act in
      conformity  with  the  Declaration  of  Trust,   ByLaws  and  registration
      statement  of the  Fund  and with the  directions  of the  Board  and Fund
      executive officers and will conform to and comply with the requirements of
      the  1940  Act  and  all  other  applicable  Federal  or  state  laws  and
      regulations.

5.    SERVICES NOT EXCLUSIVE.  INVESCO's services hereunder are not deemed to be
      exclusive,  and INVESCO is free to render administrative or other services
      to other trusts, funds or clients so long as INVESCO's services under this
      Agreement are not impaired  thereby and INVESCO  submits for review by the
      GHS Board of Trustees  any  proposal  under which  INVESCO  would  provide
      administrative or other services to another closedend  investment  company
      and the GHS Board of Trustees does not object to any such proposal(s).

6.    EXPENSES.  During the term of this  Agreement,  INVESCO  will provide such
      office space and  personnel  as are  necessary to perform its duties under
      the  Agreement  at its own  expense  and will  assume  all other  expenses
      incurred by it in connection with its services under this Agreement.

7.    COMPENSATION.  For the services  provided and expenses  assumed by INVESCO
      under this Agreement,  the Fund will pay INVESCO a monthly fee computed at
      a flat rate of $250,000 per year.

8.    LIMITATION  OF  LIABILITY  OF INVESCO.  INVESCO will not be liable for any
      error of judgment  or mistake of law or for any loss  suffered by the Fund
      or its shareholders in connection with the performance of its duties under
      this  Agreement,  except a loss (as to  which it will be  liable  and will
      indemnify and hold harmless the Fund) resulting from willful  misfeasance,
      bad faith or gross  negligence  on its part,  or on the part of any of its
      employees who are serving as officers of the Fund, in the  performance  of
      its  duties or from  reckless  disregard  by it of its  duties  under this
      Agreement  or from the  inaccuracy  of any  representation  or warranty of
      INVESCO contained herein.

9.    LIMITATION  OF LIABILITY OF THE  TRUSTEES  AND  SHAREHOLDERS  OF THE FUND.
      Neither the Trustees of the Fund nor the shareholders of the Fund shall be
      liable  for any  obligations  of the Fund under  this  Agreement,  and IFG
      agrees that,  in asserting any rights or claims under this  Agreement,  it
      shall look only to the assets and  property of the Fund in  settlement  of
      such right or claim,  and not to such  Trustees or  shareholders.  INVESCO
      represents  that it has notice of the  provisions  of the  Declaration  of
      Trust of the Fund disclaiming  shareholder liability for acts or omissions
      of the Fund.



                                       3
<PAGE>

10.   DURATION  AND  TERMINATION.  This Agreement will become effective upon the
      date  hereinabove  written and shall continue in effect  thereafter  until
      terminated without penalty by IFG or the Fund upon 60 days' written notice
      to the  other  and  shall  automatically  terminate  in the  event  of its
      assignment as that term is defined in the 1940 Act.

11.   AMENDMENT  OF  THIS  AGREEMENT.  No  provision  of this  Agreement  may be
      changed,  waived,  discharged,  or  terminated  orally,  but  only  by  an
      instrument in writing signed by the party against which enforcement of the
      change, waiver, discharge or termination is sought.

12.   GOVERNING  LAW. This Agreement  shall be construed in accordance  with the
      laws of the State of Colorado and the 1940 Act;  provided,  however,  that
      paragraph 9 above will be  construed  in  accordance  with the laws of the
      Commonwealth of  Massachusetts.  To the extent that the applicable laws of
      the State of Colorado or the Commonwealth of  Massachusetts  conflict with
      the applicable provisions of the 1940 Act, the latter shall control.

13.   MISCELLANEOUS.   The  captions  in  this   Agreement   are   included  for
      convenience  of  reference  only and in no way  define or limit any of the
      provisions hereof or otherwise affect their construction or effect. If any
      provision  of this  Agreement  shall  be held or made  invalid  by a court
      decision,  statute,  rule or otherwise,  the  remainder of this  Agreement
      shall not be affected thereby.

14.   REPRESENTATIONS OF INVESCO. INVESCO represents to the Fund as follows:

      (a)   INVESCO  has been duly  incorporated  and is validly  existing  as a
            corporation  in  good  standing  under  the  laws  of the  State  of
            Delaware,  is duly  qualified as a foreign  corporation  and in good
            standing  in each  other  jurisdiction  in which  its  ownership  of
            property or its conduct of business requires such  qualification and
            in which the failure to qualify would have a material adverse effect
            on the  business  or  operations  of INVESCO  and has full power and
            authority to conduct its  business as  Administrator  of  Investment
            Companies;

      (b)   The Administration  Agreement has been duly and validly  authorized,
            executed and  delivered  by INVESCO,  complies  with all  applicable
            provisions of the 1940 Act and the rules and regulations  adopted by
            the SEC under  the 1940  Act,  and  constitutes  a legal,  valid and
            binding  obligation of INVESCO  enforceable  in accordance  with its
            terms,  subject,  as  to  enforcement,   to  applicable  bankruptcy,
            reorganization,  insolvency  or other  similar  laws  relating to or
            affecting creditors' rights generally; and



                                       4
<PAGE>

      (c)   Neither the execution and delivery of the  Administration  Agreement
            nor the consummation by INVESCO of the transactions  contemplated by
            the Administration  Agreement conflicts with, or results in a breach
            of, (i) the  charter or Bylaws of  INVESCO,  (ii) any  agreement  or
            instrument to which INVESCO is a party or by which IFG is bound,  or
            (iii) any law, rule, regulation, or order of any court, governmental
            instrumentality, securities exchange or association or arbitrator.




                                       5
<PAGE>

      IN WITNESS  WHEREOF,  the parties hereto have caused this instrument to be
executed by their officers  designated  below as of the day and year first above
written.


Attest:                       THE GLOBAL HEALTH SCIENCES FUND



/s/ Glen A. Payne                  By /s/ Dan J. Hesser
- -----------------                     ----------------------
Glen A. Payne                         Dan J. Hesser
Secretary                                      President




Attest:                       INVESCO FUNDS GROUP, INC.



/s/ Glen A. Payne                  By /s/ Ronald L. Grooms
- -----------------                     ----------------------
Glen A. Payne                         Ronald L. Grooms
Secretary                                      Senior Vice President






                                       6











                      Amendment to Administration Agreement

This is an Amendment to the Administration  Agreement (the "Agreement") made and
entered into between the INVESCO Global Health  Sciences  Fund, a  Massachusetts
business  trust  (the  "Fund"),  and  INVESCO  Funds  Group,  Inc.,  a  Delaware
corporation registered with the Securities and Exchange as an investment adviser
(the "Administrator"), effective as of the 1st day of November, 1998.

WHEREAS,  the Fund and the Administrator desire to modify the basis on which the
administrative  services fee to be paid to the  Administrator  by the Fund under
the  Agreement  is computed to provide that such fee will now by computed at the
annual rate of .10% of the Fund's daily net assets.

NOW, THEREFORE,  in consideration of the premises and mutual covenants contained
in the  Agreement,  it is  agreed  that the  provisions  of  Paragraph  7 of the
Agreement entitled "Compensation" are hereby amended to read as follows:

     Compensation.  For the services  provided and expenses assumed by
     IFG under this Agreement,  the Fund will pay IFG a monthly fee at
     the annual rate of .10% of the Fund's  daily net assets.  The fee
     is provided for hereunder shall be prorated in any month in which
     this Agreement is not in effect for the entire month.

IN WITNESS WHEREOF,  the parties have executed this Amendment on this 1st day of
November, 1998.

                                     INVESCO GLOBAL HEALTH SCIENCES FUND



Attest:/s/ Glen A. Payne             By:/s/ Mark H. Williamson
       --------------------             ----------------------
       Glen A. Payne                    Mark H. Williamson
       Secretary                        President



                                     INVESCO FUNDS GROUP, INC.



Attest:/s/ Glen A. Payne             By:/s/ Mark H. Williamson
       --------------------             ----------------------
       Glen A. Payne                    Mark H. Williamson
       Secretary                        President


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