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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(AMENDMENT NO. 5)*
AMYLIN PHARMACEUTICALS, INC
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(Name of Issuer)
Common Stock
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(Title of Class of Securities)
032346 10 8
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(CUSIP Number)
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
Page 1 of 4 Pages
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CUSIP NO. 032346 10 8 Page 2 of 4 Pages
13G
1 NAME OF REPORTING PERSON
S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HOWARD E. GREENE, JR.
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) [ ]
(b) [ ]
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
UNITED STATES
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5 SOLE VOTING POWER
293,484
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NUMBER OF
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 1,545,667
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EACH
REPORTING
PERSON 7 SOLE DISPOSITIVE POWER
WITH
293,484
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8 SHARED DISPOSITIVE POWER
1,545,667
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9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,839,151
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10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
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11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.6%
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12 TYPE OF REPORTING PERSON*
IN
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SEE INSTRUCTION BEFORE FILLING OUT!
Page 2 of 4 pages
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ITEM 1.
(a) Name of Issuer: Amylin Pharmaceuticals, Inc. ("Issuer")
(b) Address of Issuer's Principal Executive Offices: 9373 Towne Centre Drive
San Diego, CA 92121
ITEM 2.
(a) Name of Person Filing: Howard E. Greene, Jr.
(b) Address of Principal Business Office or, if none, Residence:
9373 Towne Centre Drive
San Diego, CA 92121
(c) Citizenship: United States
(d) Title of Class of Securities: Common Stock
(e) CUSIP Number: 032346 10 8
ITEM 3. NOT APPLICABLE.
ITEM 4 OWNERSHIP.
(a) Amount Beneficially Owned: 1,839,151 including 293,484 shares issuable
upon exercise of options held by Mr. Greene,
within 60 days of December 31, 1997.
Mr. Greene shares voting and dispositive
power over 1,545,667 shares held by the
following entities: 1,535,667 held in the
name of Howard E. Greene, Jr. as Trustee of
the Greene Family Trust dated 9/5/86 and
10,000 shares held in the name of the Greene
Children's Trust.
(b) Percent of Class: 5.6%
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 293,484
(ii) shares power to vote or to direct the vote: 1,545,667
(iii) sole power to dispose or to direct the disposition of: 293,484
(iv) shared power to dispose or to direct the disposition of: 1,545,667
ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS
If this statement is being filed to report the fact that as of the date hereof
the reporting person has ceased to be the beneficial owner of more than five
percent of the class of securities, check the following: [ ]
Page 3 of 4 pages
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ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON
Not applicable
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.
Not applicable.
ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP
Not applicable.
ITEM 9. NOTICE OF DISSOLUTION OF GROUP
Not applicable.
ITEM 10. CERTIFICATION
Not applicable
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.
February 17, 1998
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Date
/s/ HOWARD E. GREENE, JR.
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Signature
Howard E. Greene, Jr.
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Name/Title
Page 4 of 4 pages
