AMYLIN PHARMACEUTICALS INC
POS462B, 1998-07-23
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

    
     AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JULY 23, 1998
                                                REGISTRATION NO. 333-59639
    
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------
   
                        POST-EFFECTIVE AMENDMENT NO. 1
    
                                      TO
                                    FORM S-3
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                            ------------------------
                          AMYLIN PHARMACEUTICALS, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
 
<TABLE>
<S>                                              <C>
                    DELAWARE                                        33-0266089
          (STATE OR OTHER JURISDICTION                           (I.R.S. EMPLOYER
       OF INCORPORATION OR ORGANIZATION)                      IDENTIFICATION NUMBER)
</TABLE>
 
                            9373 TOWNE CENTRE DRIVE
                          SAN DIEGO, CALIFORNIA 92121
                                 (619) 552-2200
   (ADDRESS, INCLUDING ZIP CODE AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF
                   REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)
                            ------------------------ 
                              JOSEPH C. COOK, JR.
               CHIEF EXECUTIVE OFFICER AND CHAIRMAN OF THE BOARD
                          AMYLIN PHARMACEUTICALS, INC.
                            9373 TOWNE CENTRE DRIVE
                          SAN DIEGO, CALIFORNIA 92121
                                 (619) 552-2200
(NAME, ADDRESS, INCLUDING ZIP CODE AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF
                               AGENT FOR SERVICE)
                            ------------------------
 
                                   COPIES TO:
 
                              THOMAS A. COLL, ESQ.
                             ERIC J. LOUMEAU, ESQ.
                               COOLEY GODWARD LLP
                        4365 EXECUTIVE DRIVE, SUITE 1100
                              SAN DIEGO, CA 92121
                            ------------------------
 
        APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:
As soon as practicable after the effective date of this Registration Statement.
 
    If any of the securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box.  [ ]
 
    If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box.  [ ]
 
    If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering.  [X]
 
    If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering.  [ ]
 
    If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box.  [ ]
                        CALCULATION OF REGISTRATION FEE
 
   
<TABLE>
<S>                                  <C>                  <C>                  <C>                  <C>
=======================================================================================================================
                                                               PROPOSED              PROPOSED
                                                                MAXIMUM               MAXIMUM
                                            AMOUNT              OFFERING             AGGREGATE            AMOUNT OF
      TITLE OF EACH CLASS OF                TO BE                PRICE               OFFERING           REGISTRATION
    SECURITIES TO BE REGISTERED           REGISTERED           PER SHARE(1)           PRICE                  FEE(2)
- -----------------------------------------------------------------------------------------------------------------------
Common Stock, $.001 par value......        400,000 shares        $3.25             $1,300,000                $384
=======================================================================================================================
</TABLE>
 
(1) The proposed maximum offering price per share is based on the proposed
    offering price for the shares of the Company's Common Stock offered hereby.

(2) Fee previously paid. This post-effective amendment is being filed solely to
    correct the amounts under the columns headed "Proposed Maximum Offering
    Price Per Share" and "Proposed Maximum Aggregate Offering Price."
    
 
        THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT THAT SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(a) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(a),
MAY DETERMINE.
================================================================================

<PAGE>   2
            INCORPORATION BY REFERENCE OF REGISTRATION STATEMENT ON
                         FORM S-3 (FILE NO. 333-58831)

     Amylin Pharmaceuticals, Inc. (the "Company") hereby incorporates by
reference into this Registration Statement on Form S-3 in its entirety the
Registration Statement on Form S-3, as amended (File No. 333-58831), declared
effective on July 22, 1998 by the Securities and Exchange Commission (the
"Commission"), including each of the documents filed by the Company with the
Commission and incorporated or deemed to be incorporated by reference therein.


                                 CERTIFICATION

     The Company hereby certifies to the Commission that it has instructed its
bank to pay the Commission the filing fee of $384 for the additional securities
being registered hereby as soon as practicable (but in any event no later than
the close of business on July 23, 1998); that it will not revoke such
instructions; that it has sufficient funds in the relevant account to cover the
amount of the filing fee; and that it undertakes to confirm receipt of such
instructions by the bank on July 23, 1998.
<PAGE>   3
 
                                   SIGNATURES

    
     Pursuant to the requirements of the Securities Act of 1933, as amended, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this
post-effective Amendment No. 1 to Registration Statement to be signed on its 
behalf by the undersigned, thereunto duly authorized, in the City of San Diego,
State of California, on July 23, 1998.
     

                                          AMYLIN PHARMACEUTICALS, INC.
 
                                          By:    /s/ JOSEPH C. COOK, JR.
                                            ------------------------------------
                                                    Joseph C. Cook, Jr.
                                                Chief Executive Officer and
                                             Chairman of the Board of Directors
                                              (Principal Executive Officer and
                                                Principal Financial Officer)
 
                               POWER OF ATTORNEY

   
     Pursuant to the requirements of the Securities Act of 1933, this
post-effective Amendment No. 1 to Registration Statement has been signed below 
by the following persons in the capacities and on the dates indicated.
 
<TABLE>
<CAPTION>
                      SIGNATURE                                       TITLE                      DATE
                      ---------                                       -----                      ----
<S>                                                      <C>                                 <C>
               /s/ JOSEPH C. COOK, JR.                     Chief Executive Officer and       July 23, 1998
- -----------------------------------------------------        Chairman of the Board of
                 Joseph C. Cook, Jr.                      Directors (Principal Executive
                                                         Officer and Principal Financial
                                                                     Officer)
 
                          *                                  Treasurer and Controller        July 23, 1998
- -----------------------------------------------------     (Principal Accounting Officer)
                    Karl H. Olsen
 
                          *                                          Director                July 23, 1998
- -----------------------------------------------------
                   James C. Blair
 
                          *                                          Director                July 23, 1998
- -----------------------------------------------------
                  James C. Gaither
 
                          *                                          Director                July 23, 1998
- -----------------------------------------------------
                  Ginger L. Graham
 
                          *                                          Director                July 23, 1998
- -----------------------------------------------------
                Howard E. Greene, Jr.
 
                          *                                          Director                July 23, 1998
- -----------------------------------------------------
                  Vaughn M. Kailian
 
            *By: /s/ JOSEPH C. COOK, JR.
  ------------------------------------------------
                 Joseph C. Cook, Jr.
                  Attorney-in-fact
</TABLE>
    
 
                                     
<PAGE>   4
INDEX TO EXHIBITS

   
Exhibit
Number                   Description
- -------                  -----------
5.1            Opinion of Cooley Godward LLP.*
23.1           Consent of Ernst & Young LLP, Independent Auditors.*
23.2           Consent of Cooley Godward LLP, Reference is made to Exhibit 5.1.


* Previously filed.
    


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