<PAGE> 1
PURSUANT TO RULE 424(b)(3)
FILE NO. 333-87033
PROSPECTUS SUPPLEMENT
TO PROSPECTUS DATED MARCH 27, 2000
AMYLIN PHARMACEUTICALS, INC.
--------------------------------------------
The following represents an amendment to the table of Security Holders
appearing on page 15 of the prospectus dated March 27, 2000. Security Holders
named in the prospectus who are not represented in the following table hold such
number of shares set forth in the table appearing on page 15 of the March 27,
2000 prospectus as of the date of such table.
<TABLE>
<CAPTION>
SHARES BENEFICIALLY SHARES BENEFICIALLY
OWNED PRIOR TO THE OWNED AFTER THE
OFFERING SHARES OFFERED OFFERING(2)
------------------- BY THIS -------------------
SECURITY HOLDERS(1) NUMBER PERCENT PROSPECTUS NUMBER PERCENT
-------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C>
Funds Managed by Domain Associates,
LLC(3) ..................................... 4,441,131 7.0% 4,352,091 89,040 *
Lawrence F. DeGeorge ........................ 862,919 1.4% 11,419 851,500 1.4%
The Chase Manhattan Bank, as Trustee
for First Plaza Group Trust ................. 95,155 * 95,155 0 --
The Northern Trust Company as Trustee
of the Lucent Technologies Inc. Master
Pension Trust .............................. 81,643 * 81,643 0 --
HarbourVest Partners V - Partnership
Fund L.P. ................................... 65,249 * 65,249 0 --
Mellon Bank, N.A., Trustee for the
Bell Atlantic Master Trust .................. 59,793 * 57,093 2,700 *
Leeway & Co. ................................ 59,674 * 51,574 8,100 *
The Mohawk River Fund L.P. .................. 57,093 * 57,093 0 --
The Ford Foundation ......................... 57,093 * 57,093 0 --
</TABLE>
1.
<PAGE> 2
<TABLE>
<CAPTION>
SHARES BENEFICIALLY SHARES BENEFICIALLY
OWNED PRIOR TO THE OWNED AFTER THE
OFFERING SHARES OFFERED OFFERING (2)
------------------- BY THIS -------------------
SECURITY HOLDERS(1) NUMBER PERCENT PROSPECTUS NUMBER PERCENT
----------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C>
The Board of Trustees of the Leland
Stanford Junior University .................. 38,062 * 38,062 0 --
Boston Safe Deposit & Trust Company,
as Trustee for the SBC Master Pension
Trust........................................ 38,062 * 38,062 0 --
The Church Pension Fund ..................... 38,062 * 38,062 0 --
Nassau Capital Funds L.P. ................... 38,062 * 38,062 0 --
Gothic Corporation .......................... 30,449 * 30,449 0 --
University of Notre Dame du lac ............. 30,449 * 30,449 0 --
Boston Safe Deposit & Trust Company
for Endowment Venture Partners III, L.P. .... 28,546 * 28,546 0 --
University of Southern California ........... 26,644 * 26,644 0 --
Sofinov, Societe Financiere
D'Innovation Inc. ........................... 22,837 * 22,837 0 --
American Bible Society ...................... 18,074 * 7,612 0 --
Knightsbridge Venture Capital IV, L.P. ...... 11,419 * 11,419 0 --
California Institute of Technology .......... 11,419 * 11,419 0 --
Trustees of Boston University ............... 11,419 * 11,419 0 --
Robert M. & Janice G. Davidson .............. 11,419 * 11,419 0 --
Genentech, Inc. ............................. 11,419 * 11,419 0 --
HarbourVest Partners V - Parallel
Partnership Fund L.P. ....................... 10,875 * 10,875 0 --
Alexandria Real Estate Equities, L.P. ....... 9,378 * 4,378 5,000 *
Employees' Retirement Plan of Duke
University................................... 7,612 * 7,612 0 --
Mitsui & Co. (U.S.A.), Inc. ................. 7,612 * 7,612 0 --
Crossroads 1997 Asset Allocation II, L.P..... 5,710 * 5,710 0 --
</TABLE>
2.
<PAGE> 3
<TABLE>
<CAPTION>
SHARES BENEFICIALLY SHARES BENEFICIALLY
OWNED PRIOR TO THE OWNED AFTER THE
OFFERING SHARES OFFERED OFFERING(2)
------------------- BY THIS -------------------
SECURITY HOLDERS(1) NUMBER PERCENT PROSPECTUS NUMBER PERCENT
-------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C>
Crossroads 1997 Venture Capital
Programme I, L.P. ........................... 5,710 * 5,710 0 --
Knightsbridge Netherlands II L.P. ........... 3,806 * 3,806 0 --
Crossroads 1997 Asset Allocation I,
L.P. ........................................ 3,806 * 3,806 0 --
Crossroads 1997 Venture Capital I, L.P. ..... 3,806 * 3,806 0 --
--
</TABLE>
----------
*Less than 1%
(1) This table is based upon information supplied to us by the
Security Holders as of July 11, 2000.
(2) Assumes the sale of all of the shares that may be offered for
resale for the account of the Security Holders pursuant to this
prospectus.
(3) Includes 4,115,046 shares held by Domain Partners IV, L.P.,
122,559 shares held by DP IV Associates, L.P., 67,670 shares held
by Mr. James C. Blair and 21,370 shares which Mr. Blair has the
right to acquire within 60 days of the date of this table pursuant
to outstanding options. The number also includes 114,486 shares
held by One Palmer Square Associates IV, all of which are included
in the amount offered by this prospectus in the table. Mr. Blair
is a member of the Board of Directors of Amylin and a managing
member of One Palmer Square Associates IV, LLC. One Palmer Square
Associates IV, LLC is the general partner of Domain Partners IV,
L.P. and DP IV Associates, L.P.
The date of this Prospectus Supplement is August 24, 2000.
