AMYLIN PHARMACEUTICALS INC
SC 13D, 2000-06-26
PHARMACEUTICAL PREPARATIONS
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CUSIP NO. 032346 10 8                                          Page 1 of 7 Pages


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                 (Rule 13d-101)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13d-2(a)

                               (Amendment No. 1)1

                          Amylin Pharmaceuticals, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.001 par value
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   032346 10 8
--------------------------------------------------------------------------------
                                 (CUSIP Number)

Kathleen K. Schoemaker                   John C. MacMurray, Esq.
Domain Associates, L.L.C.                Reboul, MacMurray, Hewitt,
One Palmer Square                        Maynard & Kristol
Princeton, New Jersey 08452              45 Rockefeller Plaza
Te. (609) 683-5656                       New York, New York  10111
                                         Tel. (212) 841-5700

--------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                  June 16, 2000
                        -------------------------------
                         (Date of Event Which Requires
                           Filing of This Statement)

          If the filing person has previously  filed a statement on Schedule 13G
to report the  acquisition  which is the subject of this  Schedule  13D,  and is
filing this schedule because of Rule 13d- 1(e), 13d-1(f) or 13d-1(g),  check the
following box [ ].

     [FN] The  remainder  of this over page shall be filled out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter  disclosures  provided in a prior cover page. The information  required on
the  remainder  of this cover  page  shall not be deemed to be  "filed"  for the
purpose  of  Section  18 of the  Securities  Exchange  Act of 1934 or  otherwise
subject to the  liabilities  of that  section of the Act but shall be subject to
all other provisions of the Act.


<PAGE>


CUSIP NO. 032346 10 8                                          Page 2 of 7 Pages



--------------------------------------------------------------------------------
1)       Name of Reporting Person                         Domain Partners
         I.R.S. Identification                            IV, L.P.
         No. of Above Person
         (If an Entity)
--------------------------------------------------------------------------------
2)       Check the Appropriate Box                            (a) [x]
         if a Member of a Group                               (b) [ ]

--------------------------------------------------------------------------------
3)       SEC Use Only

--------------------------------------------------------------------------------
4)       Source of Funds                                  Not Applicable

--------------------------------------------------------------------------------
5)       Check if Disclosure of
         Legal Proceedings is                             Not Applicable
         Required Pursuant to
         Items 2(d) or 2(e)

--------------------------------------------------------------------------------
6)       Citizenship or Place
         of Organization                                    Delaware

--------------------------------------------------------------------------------
Number of                          7)  Sole Voting       5,115,046 shares of
Shares Beneficially                    Power             Common Stock
Owned by Each
Reporting Person
With
                                   ---------------------------------------------
                                   8)  Shared Voting
                                       Power                     -0-

                                   ---------------------------------------------
                                   9)  Sole Disposi-     5,115,046 shares of
                                       tive Power        Common Stock

                                   ---------------------------------------------
                                   10) Shared Dis-
                                       positive Power            -0-

                                   ---------------------------------------------
11)      Aggregate Amount Beneficially                   5,115,046 shares of
         Owned by Each Reporting Person                  Common Stock

--------------------------------------------------------------------------------
12)      Check if the Aggregate
         Amount in Row (11)
         Excludes Certain Shares

--------------------------------------------------------------------------------
13)      Percent of Class
         Represented by                                            8.1%
         Amount in Row (11)

--------------------------------------------------------------------------------
14)      Type of Reporting
         Person                                                   PN

<PAGE>

CUSIP NO. 032346 10 8                                          Page 3 of 7 Pages



1)       Name of Reporting Person                         DP IV Associates,
         I.R.S. Identification                            L.P.
         No. of Above Person
         (If an Entity)
--------------------------------------------------------------------------------
2)       Check the Appropriate Box                            (a) [x]
         if a Member of a Group                               (b) [ ]

--------------------------------------------------------------------------------
3)       SEC Use Only

--------------------------------------------------------------------------------
4)       Source of Funds                                    Not Applicable

--------------------------------------------------------------------------------
5)       Check if Disclosure of
         Legal Proceedings is                               Not Applicable
         Required Pursuant to
         Items 2(d) or 2(e)

--------------------------------------------------------------------------------
6)       Citizenship or Place
         of Organization                                     Delaware

--------------------------------------------------------------------------------
Number of                          7)  Sole Voting       122,559 shares of
Shares Beneficially                    Power             Common Stock
Owned by Each
Reporting Person
With
                                   ---------------------------------------------
                                   8)  Shared Voting
                                       Power                     -0-

                                   ---------------------------------------------
                                   9)  Sole Disposi-     122,559 shares of
                                       tive Power        Common Stock

                                   ---------------------------------------------
                                   10) Shared Dis-
                                       positive Power            -0-

                                   ---------------------------------------------
11)      Aggregate Amount Beneficially                   122,559 shares of
         Owned by Each Reporting Person                  Common Stock

--------------------------------------------------------------------------------
12)      Check if the Aggregate
         Amount in Row (11)
         Excludes Certain Shares

--------------------------------------------------------------------------------
13)      Percent of Class
         Represented by                                            .2%
         Amount in Row (11)

--------------------------------------------------------------------------------
14)      Type of Reporting
         Person                                                   PN


<PAGE>


CUSIP NO. 032346 10 8                                          Page 4 of 7 Pages

1)       Name of Reporting Person                         Domain Partners II,
         I.R.S. Identification                            L.P.
         No. of Above Person
         (If an Entity)
--------------------------------------------------------------------------------
2)       Check the Appropriate Box                            (a) [x]
         if a Member of a Group                               (b) [ ]

--------------------------------------------------------------------------------
3)       SEC Use Only

--------------------------------------------------------------------------------
4)       Source of Funds                                  Not Applicable

--------------------------------------------------------------------------------
5)       Check if Disclosure of
         Legal Proceedings is                             Not Applicable
         Required Pursuant to
         Items 2(d) or 2(e)

--------------------------------------------------------------------------------
6)       Citizenship or Place
         of Organization                                    Delaware

--------------------------------------------------------------------------------
Number of                          7)  Sole Voting
Shares Beneficially                    Power                     -0-
Owned by Each
Reporting Person
With
                                   ---------------------------------------------
                                   8)  Shared Voting
                                       Power                     -0-

                                   ---------------------------------------------
                                   9)  Sole Disposi-
                                       tive Power                -0-

                                   ---------------------------------------------
                                   10) Shared Dis-
                                       positive Power            -0-

                                   ---------------------------------------------
11)      Aggregate Amount Beneficially
         Owned by Each Reporting Person                          -0-

--------------------------------------------------------------------------------
12)      Check if the Aggregate
         Amount in Row (11)
         Excludes Certain Shares

--------------------------------------------------------------------------------
13)      Percent of Class
         Represented by                                           0%
         Amount in Row (11)

--------------------------------------------------------------------------------
14)      Type of Reporting
         Person                                                   PN



<PAGE>


CUSIP NO. 032346 10 8                                          Page 5 of 7 Pages


                         AMENDMENT NO. 1 TO SCHEDULE 13D

          Reference is hereby made to the  statement on Schedule 13D  originally
filed  with the  Securities  and  Exchange  Commission  on April  2,  1999  (the
"Schedule  13D").  Terms  defined  in the  Schedule  13D are used  herein  as so
defined.


Item 5.   INTEREST IN SECURITIES OF THE ISSUER.
          ------------------------------------

          Item 5 is hereby  amended  and  restated  to read in its  entirety  as
follows:

          The following  information is based on a total of 62,861,928 shares of
Common Stock outstanding as of May 5, 2000.

          (a)

          DP IV
          -----

          DP IV owns 5,115,046 shares of Common Stock, or approximately  8.1% of
the Common Stock  outstanding.  OPSA IV, as the general partner of DP IV, may be
deemed to beneficially own the shares of Common Stock owned by DP IV.

          DP IV A
          -------

          DP IV A owns 122,559 shares of Common Stock, or approximately  0.2% of
the Common Stock outstanding. OPSA IV, as the general partner of DP IV A, may be
deemed to beneficially own the shares of Common Stock owned by DP IV A.

          DP II
          -----

          As a result of the  distribution  described in paragraph (c) below, DP
II does not own any shares of Common  Stock and OPSA II, the general  partner of
DP II,  directly  and  beneficially  owns  135,996  shares of Common  Stock,  or
approximately .2% of the Common Stock outstanding.

          MANAGING MEMBERS OF OPSA IV AND GENERAL PARTNERS OF
          OPSA II
          -------

          (i) James C.  Blair  owns  63,871  shares of Common  Stock,  including
20,000  shares  issuable  upon  exercise  of stock  options  that are  presently
exercisable  or  exercisable  within 60 days of the date of this  statement,  or
approximately 0.1% of the Common Stock outstanding.




<PAGE>


CUSIP NO. 032346 10 8                                          Page 6 of 7 Pages


          (ii) Jesse I. Treu owns 28,792  shares of Common  Stock,  or less than
0.1% of the Common Stock outstanding.

          (iii) Brian H. Dovey owns 28,792 shares of Common Stock,  or less than
0.1% of the Common Stock outstanding.

          (iv) Kathleen K. Schoemaker owns 3,131 shares of Common Stock, or less
than 0.1% of the Common Stock outstanding.

          (v) Arthur J. Klausner owns 1,500 shares of Common Stock, or less than
0.1% of the Common Stock outstanding.

          (b) The managing  members of OPSA IV and the general  partners of OPSA
II may be  deemed to share  the  power to vote or  direct  the  voting of and to
dispose or direct the  disposition  of the Common  Stock owned by DP IV, DP IV A
and DP II. Each of the managing  members of OPSA IV and general partners of OPSA
II disclaims  beneficial  ownership of all shares of Common Stock other than the
shares  of  Common  Stock he or she owns  directly,  or by  virtue of his or her
indirect  pro rata  interest,  as a  managing  member of OPSA IV and/or  general
partner of OPSA II, in the Common Stock owned by DP IV, DP IV A and/or DP II.

          (c) On June 16, 2000, DP II distributed an aggregate 653,847 shares of
Common Stock (representing all the shares of Common Stock directly  beneficially
owned  by DP  II) to its  partners,  including  135,996  shares  to its  general
partner, OPSA II. OPSA II will distribute such 135,996 shares to its partners at
a later date.

          (d) Except as described in this statement,  no person has the power to
direct the receipt of dividends on, or the proceeds from sales of, the shares of
Common Stock owned by DP IV, DP IV A or DP II.

          (e) Not applicable.




<PAGE>


CUSIP NO. 032346 10 8                                          Page 7 of 7 Pages



                                    SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated: June 26, 2000


                                            DOMAIN PARTNERS IV, L.P.
                                            By:  One Palmer Square Associates
                                            IV L.L.C., General Partner

                                            By /s/ Kathleen K. Schoemaker
                                               ---------------------------------
                                                     Managing Member

                                            DP IV ASSOCIATES, L.P.
                                            By:  One Palmer Square Associates
                                            IV L.L.C., General Partner

                                            By /s/ Kathleen K. Schoemaker
                                               ---------------------------------
                                                     Managing Member

                                            DOMAIN PARTNERS II, L.P.
                                            By:  One Palmer Square Associates
                                            II, L.P., General Partner

                                            By  /s/ Kathleen K. Schoemaker
                                               ---------------------------------
                                                     Attorney-in-Fact



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