DREYFUS GROWTH & INCOME FUND INC /NEW/
N-30D, 1999-12-22
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Dreyfus

Growth and Income

Fund, Inc.

ANNUAL REPORT October 31, 1999

(reg.tm)





The  views  expressed herein are current to the date of this report. These views
and  the  composition  of the fund's portfolio are subject to change at any time
based on market and other conditions.

   * Not FDIC-Insured  * Not Bank-Guaranteed  * May Lose Value

Year 2000 Issues (Unaudited)

The fund could be adversely affected if the computer systems used by The Dreyfus
Corporation and the fund's other service providers do not properly process and
calculate date-related information from and after January 1, 2000. The Dreyfus
Corporation is working to avoid Year 2000-related problems in its systems and to
obtain assurances from other service providers that they are taking similar
steps. In addition, issuers of securities in which the fund invests may be
adversely affected by Year 2000-related problems. This could have an impact on
the value of the fund's investments and its share price.


                                 Contents

                                 THE FUND
- --------------------------------------------------

                             2   Letter from the President

                             3   Discussion of Fund Performance

                             6   Fund Performance

                             7   Statement of Investments

                            12   Statement of Financial Futures

                            13   Statement of Assets and Liabilities

                            14   Statement of Operations

                            15   Statement of Changes in Net Assets

                            16   Financial Highlights

                            17   Notes to Financial Statements

                            22   Report of Independent Auditors

                            23   Important Tax Information

                                 FOR MORE INFORMATION
- ---------------------------------------------------------------------------

                                 Back Cover

                                                                       The Fund

                                                                        Dreyfus

                                                   Growth and Income Fund, Inc.

LETTER FROM THE PRESIDENT

Dear Shareholder:

We are pleased to present this annual report for Dreyfus Growth and Income Fund,
covering  the  12-month  period  from November 1, 1998 through October 31, 1999.
Inside,  you' ll find valuable information about how the fund was managed during
the  reporting period, including a discussion with the fund's portfolio manager,
Douglas D. Ramos,CFA.

Despite  a  relatively weak third quarter of 1999 for the U.S. stock market, the
past  year  has  been  rewarding  for  most  equity  investors overall. When the
reporting  period  began,  most sectors of the U.S. stock market had completed a
sharp correction caused primarily by concerns regarding the spread of the global
financial  crisis  in  overseas  markets. Soon after the start of 1999, however,
those  fears abated. In fact, the U.S. economy remained strong, characterized by
low  inflation  and high levels of consumer spending. These conditions supported
continued    strength    in    the    stock   market   through   the   spring.

In  the  summer  of  1999,  however, the Federal Reserve Board raised short-term
interest  rates  twice  in  an  effort  to forestall inflationary pressures in a
fast-growing economy. Because higher interest rates tend to increase the cost of
capital  and make fixed-income securities more competitive relative to equities,
most  sectors of the stock market declined. By the end of the 12-month reporting
period,  major stock indices had fallen from the record highs reached during the
summer,  although  stock  prices  generally were still higher than they were one
year earlier.

We  appreciate  your  confidence over the past year, and we look forward to your
continued    participation    in    Dreyfus    Growth    and    Income   Fund.

Sincerely,


Stephen E. Canter

President and Chief Investment Officer

The Dreyfus Corporation

November 15, 1999




DISCUSSION OF FUND PERFORMANCE

Douglas D. Ramos, CFA, Portfolio Manager

How did Dreyfus Growth and Income Fund perform relative to its benchmark?

The fund produced a total return of 19.79% during the 12-month period that ended
October  31,  1999.  This  compares  to  a  25.66%  total  return for the fund's
benchmark,  the  Standard  & Poor' s  500  Composite Stock Price Index ("S&P 500
Index"   ).

We  attribute  the  fund' s  good absolute performance to the surprisingly rapid
recovery  of  global  capital  markets  that occurred in late 1998 and continued
through  the  fund' s  first and second quarters. During those two quarters, the
fund  reported  its strongest gains. However, the recovery was especially strong
among a narrow group of very large growth stocks, of which the S&P 500 Index was
more  heavily  weighted  than the fund. As a result, the Index rose more rapidly
than the fund did.

What is the fund's investment approach?

Dreyfus  Growth  and  Income  Fund  invests  primarily  in  mid-sized  and large
companies   that   we  believe  have  above-average  growth  potential  and  are
attractively  valued  relative  to the S&P 500 Index. We generally look to avoid
the risks associated with market timing.

We  typically  measure  a  stock' s  relative  value  by looking at its price in
relation to the company's business prospects and intrinsic worth, as measured by
a  wide  range  of  financial  and  business  data.  By examining each company's
fundamentals,  together with economic and industry trends, we typically look for
factors  that could trigger a rise in the stock's price, such as new competitive
opportunities  or  internal operational improvements. The result of our approach
during  the  recent  12-month  period  was  a portfolio containing stocks from a
number    of    different    market    sectors    and    industries.

                                                             The Fund


DISCUSSION OF FUND PERFORMANCE (CONTINUED)

What other factors influenced the fund's performance?

As  we  mentioned  earlier,  the  strong rise of the benchmark was driven by the
performance of a narrow group of companies, most of which were in the technology
sector.  While  the  fund benefited from owning significant positions in some of
these  stocks  --  such  as  semiconductor  equipment  maker  Applied Materials,
computer server maker Sun Microsystems and business software developer Oracle --
others  failed  to meet our investment criteria. Our performance relative to our
benchmark suffered because we did not own these other stocks.

Nevertheless,  the  fund' s  technology  holdings  generally  performed strongly
throughout   the  period.  In  addition  to  the  computer-related  technologies
mentioned above, the communications technology sector also showed strong growth,
driven  by rapidly increasing demand for cellular services as well as line-based
analog  and  digital  communications. The fund benefited from investments in key
communications  equipment  and  services  companies, such as Nortel Networks and
Ericsson  (LM) Telephone. The technology sector has been among the most volatile
sectors in the stock market. Of course, not all of the fund's technology-related
holdings performed well. Some, such as Compaq Computer, disappointed in the face
of strong competitive pressures.

Most  other  sectors  remained  generally  flat  or suffered declines during the
period.  The  most significant declines occurred in the consumer staples sector,
where concerns about the impact of Internet-based shopping on the food retailing
industry hurt stock prices. The fund's holdings in companies such as Albertson's
and  Safeway declined as a result. The interest-rate-sensitive consumer cyclical
sector  was  also hard hit by rising interest rates, hurting the fund's holdings
in    such    companies    as    Ford    Motor    and    Black    & Decker.

The  financial  industry,  which  represented the fund's single largest group of
holdings,  was particularly volatile. During the first few months of the period,
financial  stocks reacted well to the continued strength of the U.S. economy and
the  apparent stabilization of many global economies. After showing sharp gains,
however,    many    banking    and    insurance

stocks  declined  in response to rising interest rates. We viewed these declines
as  buying opportunities, increasing some of our positions in the sector. As the
period  drew to a close, financial stocks once again rallied as evidence mounted
that inflation remained in check.

What is the fund's current strategy?

We  adjusted  our  strategy during the reporting period in an effort to give the
fund  added  flexibility  to  hold  stocks that we believe are moderately valued
relative  to the benchmark, as well as those that we believe are undervalued. In
the  past,  our  investment  discipline  often led us to avoid moderately valued
stocks  with  excellent growth potential, or to sell a stock relatively early in
its growth cycle, causing the fund to miss out on subsequent appreciation.

This  adjustment  in  our  strategy  benefited  the  fund  over the past year by
allowing  us  to purchase shares of moderately priced technology stocks, such as
Electronic  Data  Systems,  which later rose sharply. Our modified strategy also
allowed  us to hold appreciating shares of companies, such as Lexmark and Intel,
which subsequently rose further in value.

We  continue  to  adhere  to  our  disciplined  investment  approach  by seeking
attractively  priced  securities  that  we  believe  offer  above-average growth
potential.

November 15, 1999

(1)  TOTAL RETURN INCLUDES REINVESTMENT OF DIVIDENDS AND ANY CAPITAL GAINS PAID.
PAST PERFORMANCE IS NO GUARANTEE OF FUTURE RESULTS. SHARE PRICE AND INVESTMENT
RETURN FLUCTUATE SUCH THAT UPON REDEMPTION FUND SHARES MAY BE WORTH MORE OR LESS
THAN THEIR ORIGINAL COST.

(1)  SOURCE: LIPPER ANALYTICAL SERVICES, INC. -- REFLECTS THE REINVESTMENT OF
INCOME DIVIDENDS AND, WHERE APPLICABLE, CAPITAL GAIN DISTRIBUTIONS. THE STANDARD
& POOR'S 500 COMPOSITE STOCK PRICE INDEX IS A WIDELY ACCEPTED, UNMANAGED INDEX
OF U.S. STOCK MARKET PERFORMANCE.

                                                             The Fund

FUND PERFORMANCE

Comparison of change in value of $10,000 investment in Dreyfus Growth and Income
Fund, Inc. and the Standard & Poor's 500 Composite Stock Price Index
- --------------------------------------------------------------------------------

Average Annual Total Returns AS OF 10/31/99
<TABLE>
<CAPTION>


                                                  Inception                                                           From
                                                    Date                 1 Year                5 Years              Inception
- ------------------------------------------------------------------------------------------------------------------------------------

<S>                                                <C>                     <C>                 <C>                    <C>
FUND                                               12/31/91                19.79%              14.42%                 13.74%
</TABLE>


((+))  SOURCE: LIPPER ANALYTICAL SERVICES, INC.

PAST PERFORMANCE IS NOT PREDICTIVE OF FUTURE PERFORMANCE.

THE ABOVE GRAPH COMPARES A $10,000 INVESTMENT MADE IN DREYFUS GROWTH AND INCOME
FUND, INC.  ON 12/31/91 (INCEPTION DATE) TO A $10,000 INVESTMENT MADE IN THE
STANDARD & POOR'S 500 COMPOSITE STOCK PRICE INDEX ON THAT DATE. ALL DIVIDENDS
AND CAPITAL GAIN DISTRIBUTIONS ARE REINVESTED.

THE FUND'S PERFORMANCE SHOWN IN THE LINE GRAPH TAKES INTO ACCOUNT ALL APPLICABLE
FEES AND EXPENSES. UNLIKE THE FUND, WHICH CAN INVEST IN BOTH EQUITY AND DEBT
SECURITIES, THE STANDARD & POOR'S 500 COMPOSITE STOCK PRICE INDEX IS A WIDELY
ACCEPTED, UNMANAGED INDEX OF U.S. STOCK MARKET PERFORMANCE COMPRISED SOLELY OF
COMMON STOCKS. THE INDEX DOES NOT TAKE INTO ACCOUNT CHARGES, FEES AND OTHER
EXPENSES. FURTHER INFORMATION RELATING TO FUND PERFORMANCE, INCLUDING EXPENSE
REIMBURSEMENTS, IF APPLICABLE, IS CONTAINED IN THE FINANCIAL HIGHLIGHTS SECTION
OF THE PROSPECTUS AND ELSEWHERE IN THIS REPORT.




STATEMENT OF INVESTMENTS

<TABLE>
<CAPTION>


October 31, 1999

COMMON STOCKS--93.8%                                                                   Shares                          Value ($)
- ------------------------------------------------------------------------------------------------------------------------------------

BASIC INDUSTRIES--1.5%

<S>                                                                                     <C>                            <C>
Dow Chemical                                                                            67,000                         7,922,750

International Paper                                                                    161,000                         8,472,625

Weyerhaeuser                                                                           123,100                         7,347,531

                                                                                                                      23,742,906

CHEMICALS--.3%

duPont (E.I.) deNemours                                                                 80,000                         5,155,000

COMMERCIAL SERVICES--1.0%

McGraw-Hill Cos.                                                                       188,400                        11,233,350

Outdoor Systems                                                                        113,000  (a)                    4,788,375

                                                                                                                      16,021,725

CONSUMER DURABLES--1.3%

Ford Motor                                                                             149,900                         8,225,763

General Motors                                                                          47,000                         3,301,750

Leggett & Platt                                                                        401,500                         8,908,281

                                                                                                                      20,435,794

CONSUMER NON-DURABLES--3.1%

Anheuser-Busch Cos.                                                                     42,000                         3,016,125

Heinz (H.J.)                                                                           148,000                         7,067,000

Intimate Brands                                                                         77,000                         3,157,000

Kimberly-Clark                                                                         175,000                        11,046,875

PepsiCo                                                                                728,000                        25,252,500

                                                                                                                      49,539,500

CONSUMER SERVICES--7.0%

Adelphia Communications, Cl.A                                                          148,900                         8,133,662

American Tower, Cl. A                                                                  384,100                         7,321,906

CBS                                                                                    228,000  (a)                   11,129,250

Carnival                                                                               414,300                        18,436,350

Cendant                                                                              1,429,400                        23,585,100

Clear Channel Communications                                                            58,000                         4,661,750

Gannett                                                                                228,800                        17,646,200

McDonald's                                                                             182,000                         7,507,500

Time Warner                                                                            168,200                        11,721,438

                                                                                                                     110,143,156

ELECTRONIC TECHNOLOGY--15.5%

Apple Computer                                                                          60,000  (a)                    4,807,500

Applied Materials                                                                      140,000  (a)                   12,573,750

Cabletron Systems                                                                      251,900  (a)                    4,172,094

                                                                                                     The Fund

STATEMENT OF INVESTMENTS (CONTINUED)

COMMON STOCKS (CONTINUED)                                                               Shares                         Value ($)
- ------------------------------------------------------------------------------------------------------------------------------------

ELECTRONIC TECHNOLOGY (CONTINUED)

Computer Sciences                                                                      247,600  (a)                   17,007,025

Ericsson (LM) Telephone, Cl. B, A.D.R.                                                 435,000                        18,596,250

General Dynamics                                                                       169,000                         9,368,937

Hewlett-Packard                                                                         84,600                         6,265,687

Intel                                                                                  470,100                        36,403,369

International Business Machines                                                        320,000                        31,480,000

LSI Logic                                                                              331,000  (a)                   17,605,062

Lexmark International Group, Cl. A                                                     178,700  (a)                   13,949,769

Motorola                                                                               145,000                        14,128,438

National Semiconductor                                                                 288,000                         8,622,000

Nortel Networks                                                                        248,000                        15,360,500

Sun Microsystems                                                                        48,000                         5,079,000

Teradyne                                                                               242,000                         9,317,000

Texas Instruments                                                                       53,000                         4,756,750

United Technologies                                                                    238,000                        14,399,000

                                                                                                                     243,892,131

ENERGY MINERALS--5.4%

Burlington Resources                                                                    73,000                         2,545,875

Conoco, Cl. A                                                                          320,000                         8,780,000

Exxon                                                                                  196,000                        14,516,250

Mobil                                                                                   76,000                         7,334,000

Royal Dutch Petroleum, A.D.R.                                                          479,000                        28,710,062

Texaco                                                                                 266,500                        16,356,438

USX-Marathon Group                                                                     242,000                         7,048,250

                                                                                                                      85,290,875

FINANCE--16.0%

American Express                                                                        62,000                         9,548,000

American General                                                                       115,300                         8,553,819

American International Group                                                           220,771                        22,725,615

Associates First Capital, Cl. A                                                        258,000                         9,417,000

Bank of America                                                                        368,400                        23,715,750

Chase Manhattan                                                                        252,000                        22,018,500

CIGNA                                                                                  113,700                         8,499,075

Citigroup                                                                              630,650                        34,133,931

Federal Home Loan Mortgage                                                             205,200                        11,093,625

Federal National Mortgage Association                                                  360,500                        25,505,375

Fleet Boston                                                                           470,036                        20,505,320

Household International                                                                132,800                         5,926,200


COMMON STOCKS (CONTINUED)                                                               Shares                          Value ($)
- ------------------------------------------------------------------------------------------------------------------------------------

FINANCE (CONTINUED)

Morgan (J.P.)                                                                           67,000                         8,768,625

Morgan Stanley, Dean Witter                                                            163,500                        18,036,094

Wells Fargo                                                                            398,000                        19,054,250

XL Capital, Cl. A                                                                      100,000                         5,368,750

                                                                                                                     252,869,929

HEALTH SERVICES--2.8%

Columbia/HCA Healthcare                                                              1,032,200                        24,901,825

Wellpoint Health Networks                                                              335,400  (a)                   19,453,200

                                                                                                                      44,355,025

HEALTH TECHNOLOGY--5.4%

Bristol-Myers Squibb                                                                   246,000                        18,895,875

Johnson & Johnson                                                                      191,000                        20,007,250

Lilly (Eli)                                                                            103,100                         7,101,013

Merck & Co.                                                                            283,000                        22,516,187

Pharmacia & Upjohn                                                                     213,700                        11,526,444

Warner-Lambert                                                                          60,000                         4,788,750

                                                                                                                      84,835,519

INDUSTRIAL SERVICES--2.1%

Baker Hughes.                                                                          454,800                        12,705,975

Schlumberger                                                                           334,000                        20,227,875

                                                                                                                      32,933,850

NON-ENERGY MINERALS--.3%

Alcoa                                                                                   67,000                         4,070,250

PROCESS INDUSTRIES-.8%

Champion International                                                                  81,000                         4,682,813

Rohm & Haas                                                                            223,200                         8,537,400

                                                                                                                      13,220,213

PRODUCER MANUFACTURING--9.0%

AlliedSignal                                                                           321,000                        18,276,937

Emerson Electric                                                                       139,000                         8,348,688

General Electric                                                                       479,000                        64,934,438

Honeywell                                                                              149,000                        15,710,187

Industrial Flexible Material                                                           725,000  (a,c)                         --

Ingersoll-Rand                                                                          78,600                         4,106,850

Masco                                                                                  504,500                        15,387,250

Tyco International                                                                     369,000                        14,736,938

                                                                                                                     141,501,288

                                                                                                     The Fund

STATEMENT OF INVESTMENTS (CONTINUED)

COMMON STOCKS (CONTINUED)                                                               Shares                         Value ($)
- ------------------------------------------------------------------------------------------------------------------------------------

RETAIL TRADE--4.5%

Albertson's                                                                            185,277                         6,727,871

Dayton Hudson                                                                          382,000                        24,686,750

Federated Department Stores                                                            160,600  (a)                    6,855,612

Kroger                                                                                 204,000  (a)                    4,245,750

Lowes                                                                                  221,600                        12,188,000

May Department Stores                                                                  174,350                         6,047,766

TJX Cos.                                                                               389,200                        10,557,050

                                                                                                                      71,308,799

TECHNOLOGY SERVICES--5.6%

BMC Software                                                                           121,500  (a)                    7,798,781

Computer Associates International                                                      426,000                        24,069,000

Compuware                                                                              237,200  (a)                    6,597,125

Electronic Data Systems                                                                329,000                        19,246,500

Network Associates                                                                     281,000  (a)                    5,145,812

Oracle                                                                                 282,000  (a)                   13,412,625

Synopsys                                                                               197,500                        12,306,719

                                                                                                                      88,576,562

TRANSPORTATION--.4%

AMR                                                                                    101,000  (a)                    6,413,500

UTILITIES--11.8%

AT&T                                                                                   442,500                        20,686,875

Bell Atlantic                                                                          323,000                        20,974,812

Coastal                                                                                483,100                        20,350,588

El Paso Energy                                                                          92,000                         3,772,000

Enron                                                                                  189,000                         7,548,187

GTE                                                                                    390,000                        29,250,000

MCI WorldCom                                                                           322,200  (a)                   27,648,788

Niagara Mohawk Power                                                                   141,000  (a)                    2,238,375

SBC Communications                                                                     478,600                        24,378,687

Sprint                                                                                 334,600                        24,864,963

Texas Utilities                                                                        117,800                         4,564,750

                                                                                                                     186,278,025

TOTAL COMMON STOCKS

   (cost $1,192,615,540)                                                                                           1,480,584,047


                                                                                     Principal
SHORT-TERM INVESTMENTS--4.9%                                                        Amount ($)                        Value ($)
- ------------------------------------------------------------------------------------------------------------------------------------

U.S. TREASURY BILLS:

   4.50%, 11/4/1999                                                                 20,020,000                        20,012,393

   4.40%, 11/12/1999                                                                13,824,000                        13,805,338

   4.48%, 12/2/1999                                                                  6,782,000                         6,757,042

   4.48%, 12/9/1999                                                                 16,577,000                        16,499,585

   4.54%, 12/23/1999                                                                20,367,000  (b)                   20,236,855

TOTAL SHORT-TERM INVESTMENTS

   (cost $77,305,796)                                                                                                 77,311,213
- ------------------------------------------------------------------------------------------------------------------------------------

TOTAL INVESTMENTS (cost $1,269,921,336)                                                  98.7%                     1,557,895,260

CASH AND RECEIVABLES (NET)                                                                1.3%                        20,000,229

NET ASSETS                                                                              100.0%                     1,577,895,489

(A) NON-INCOME PRODUCING.

(B) PARTIALLY HELD BY THE CUSTODIAN IN A SEGREGATED ACCOUNT AS COLLATERAL FOR OPEN FINANCIAL FUTURES POSITIONS.

(C) SECURITY RESTRICTED TO PUBLIC RESALE:
</TABLE>

<TABLE>
<CAPTION>



                                          Acquisition  Purchase   Percentage of
Issuer                                           Date  Price         Net Assets             Valuation*
- ------------------------------------------------------------------------------------------------------------------------------------

<S>                                         <C>        <C>                   <C>                  <C>
Industrial Flexible Material                3/31/1993  $5.00                .00                   Zero

*   THE VALUATION OF THIS SECURITY HAS BEEN DETERMINED IN GOOD FAITH UNDER THE
    DIRECTION OF THE BOARD OF DIRECTORS.
</TABLE>


                                                                       The Fund

STATEMENT OF FINANCIAL FUTURES

October 31, 1999

<TABLE>
<CAPTION>


                                                                   Market Value                                        Unrealized
                                                                        Covered                                      Appreciation
Financial Futures Long                      Contracts          by Contracts ($)           Expiration              at 10/31/99 ($)
- ------------------------------------------------------------------------------------------------------------------------------------

<S>                                               <C>                <C>                <C>                    <C>
Standard & Poor's 500                             274                94,269,700         December '99                     3,879,202

SEE NOTES TO FINANCIAL STATEMENTS.
</TABLE>




STATEMENT OF ASSETS AND LIABILITIES

October 31, 1999

                                                             Cost         Value
- --------------------------------------------------------------------------------

ASSETS ($):

Investments in securities--See Statement of
Investments                                        1,269,921,336  1,557,895,260

Cash                                                                  5,148,214

Receivable for investment securities sold                            27,474,049

Receivable for futures variation margin--Note 4(a)                    1,634,837

Dividends receivable                                                    983,460

Receivable for shares of Common Stock subscribed                          2,537

Prepaid expenses                                                         63,237

                                                                  1,593,201,594
- --------------------------------------------------------------------------------

LIABILITIES ($):

Due to The Dreyfus Corporation and affiliates                         1,127,112

Due to Distributor                                                      643,632

Payable for investment securities purchased                          10,608,983

Payable for shares of Common Stock redeemed                           2,659,849

Accrued expenses                                                        266,529

                                                                     15,306,105
- --------------------------------------------------------------------------------

NET ASSETS ($)                                                    1,577,895,489
- --------------------------------------------------------------------------------

COMPOSITION OF NET ASSETS ($):

Paid-in capital                                                    1,120,354,14

Accumulated undistributed investment income--net                        413,582

Accumulated net realized gain (loss) on investments                 165,274,633

Accumulated net unrealized appreciation (depreciation)
   on investments (including $3,879,202 net unrealized
   appreciation on financial futures)--Note 4(b)                    291,853,126
- --------------------------------------------------------------------------------

NET ASSETS ($)                                                    1,577,895,489
- --------------------------------------------------------------------------------

SHARES OUTSTANDING

(300 million shares of $.001 par value Common Stock authorized)      78,922,104

NET ASSET VALUE, offering and redemption price per share ($)              19.99

SEE NOTES TO FINANCIAL STATEMENTS.

                                                             The Fund

STATEMENT OF OPERATIONS

Year Ended October 31, 1999

- --------------------------------------------------------------------------------

INVESTMENT INCOME ($):

INCOME:

Cash dividends (net of $188,079 foreign taxes withheld at source)   22,513,199

Interest                                                             3,831,504

TOTAL INCOME                                                        26,344,703

EXPENSES:

Management fee--Note 3(a)                                           12,395,355

Shareholder servicing costs--Note 3(b)                               4,239,182

Custodian fees--Note 3(b)                                              130,412

Prospectus and shareholders' reports                                    79,246

Directors' fees and expenses--Note 3(c)                                 76,303

Professional fees                                                       75,713

Interest expense--Note 2                                                53,299

Registration fees                                                       32,278

Miscellaneous                                                           57,608

TOTAL EXPENSES                                                      17,139,396

INVESTMENT INCOME--NET                                               9,205,307
- --------------------------------------------------------------------------------

REALIZED AND UNREALIZED GAIN (LOSS) ON INVESTMENTS--NOTE 4 ($):

Net realized gain (loss) on investments:

Long transactions (including foreign currency transactions)        130,798,314

Short sale transactions                                               (13,683)

Net realized gain (loss) on forward currency exchange contracts        435,321

Net realized gain (loss) on financial futures                       43,652,668

NET REALIZED GAIN (LOSS)                                           174,872,620

Net unrealized appreciation (depreciation) on investments and
  foreign currency transactions [including ($8,377,236)
  net unrealized (depreciation) on financial futures]              122,580,859

NET REALIZED AND UNREALIZED GAIN (LOSS) ON INVESTMENTS             297,453,479

NET INCREASE IN NET ASSETS RESULTING FROM OPERATIONS               306,658,786

SEE NOTES TO FINANCIAL STATEMENTS.


STATEMENT OF CHANGES IN NET ASSETS

                                                       Year Ended October 31,
                                                    ----------------------------

                                                     1999                1998
- --------------------------------------------------------------------------------

OPERATIONS ($):

Investment income--net                          9,205,307           18,187,162

Net realized gain (loss) on investments       174,872,620           82,929,950

Net unrealized appreciation (depreciation)
   on investments                             122,580,859           44,244,823

NET INCREASE (DECREASE) IN NET ASSETS
   RESULTING FROM OPERATIONS                  306,658,786          145,361,935
- --------------------------------------------------------------------------------

DIVIDENDS TO SHAREHOLDERS FROM ($):

Investment income--net                       (10,712,803)         (17,696,807)

Net realized gain on investments            (102,070,849)        (295,927,118)

TOTAL DIVIDENDS                             (112,783,652)        (313,623,925)
- --------------------------------------------------------------------------------

CAPITAL STOCK TRANSACTIONS ($):

Net proceeds from shares sold                 718,800,250          816,239,753

Dividends reinvested                          107,345,114          298,840,613

Cost of shares redeemed                   (1,103,206,818)       (1,198,145,049)

INCREASE (DECREASE) IN NET ASSETS FROM
   CAPITAL STOCK TRANSACTIONS               (277,061,454)         (83,064,683)

TOTAL INCREASE (DECREASE) IN NET ASSETS      (83,186,320)        (251,326,673)
- --------------------------------------------------------------------------------

NET ASSETS ($):

Beginning of Period                         1,661,081,809        1,912,408,482

END OF PERIOD                               1,577,895,489        1,661,081,809

Undistributed investment income--net              413,582            1,921,078
- --------------------------------------------------------------------------------

CAPITAL SHARE TRANSACTIONS (SHARES):

Shares sold                                    37,570,438           44,083,320

Shares issued for dividends reinvested          6,074,347           17,179,545

Shares redeemed                              (57,679,437)         (64,800,453)

NET INCREASE (DECREASE) IN SHARES OUTSTANDING (14,034,652)         (3,537,588)

SEE NOTES TO FINANCIAL STATEMENTS.

                                                             The Fund

FINANCIAL HIGHLIGHTS

The  following table describes the performance for the fiscal periods indicated.
Total return shows how much your investment in the fund would have increased (or
decreased)  during  each  period,  assuming you had reinvested all dividends and
distributions.  These  figures  have  been  derived  from  the  fund's financial
statements.

<TABLE>
<CAPTION>


                                                                                         Year Ended October 31,
                                                             -----------------------------------------------------------------------

                                                             1999           1998            1997            1996             1995
- ------------------------------------------------------------------------------------------------------------------------------------

PER SHARE DATA ($):

<S>                                                         <C>            <C>             <C>             <C>              <C>
Net asset value, beginning of period                        17.87          19.82           20.53           17.96            16.49

Investment Operations:

Investment income--net                                       .11(a)          .18             .34             .35              .44

Net realized and unrealized
   gain (loss) on investments                               3.26            1.14            1.97            3.05             1.67

Total from Investment Operations                            3.37            1.32            2.31            3.40             2.11

Distributions:

Dividends from investment income--net                       (.12)           (.18)           (.37)           (.32)            (.47)

Dividends from net realized gain on
   investments                                             (1.13)          (3.09)          (2.65)           (.51)            (.17)

Total Distributions                                        (1.25)         (3.27)          (3.02)            (.83)          (.64)

Net asset value, end of period                             19.99          17.87           19.82            20.53          17.96
- ------------------------------------------------------------------------------------------------------------------------------------

TOTAL RETURN (%)                                           19.79           7.23           12.97            19.41          13.17
- ------------------------------------------------------------------------------------------------------------------------------------

RATIOS/SUPPLEMENTAL DATA (%):

Ratio of operating expenses to

   average net assets                                      1.03            1.10            1.01             1.02           1.05

Ratio of interest expenses and
   dividends on securities sold short
   to average net assets                                    .00(b)         --               .01              .01            .01

Ratio of net investment income
   to average net assets                                    .56             .97            1.67             1.78           2.55

Portfolio Turnover Rate                                   96.42          101.87          129.48           131.30         132.46
- ------------------------------------------------------------------------------------------------------------------------------------

Net Assets, end of period

   ($ X 1,000)                                        1,577,895       1,661,082       1,912,408        2,068,453      1,763,371

A   BASED ON AVERAGE SHARES OUTSTANDING AT EACH MONTH END.

B   AMOUNT REPRESENTS LESS THAN .01%.

SEE NOTES TO FINANCIAL STATEMENTS.
</TABLE>



NOTES TO FINANCIAL STATEMENTS

NOTE 1--Significant Accounting Policies:

Dreyfus  Growth  and  Income  Fund,  Inc.  (the  "fund") is registered under the
Investment  Company  Act  of  1940, as amended (the "Act"), as a non-diversified
open-end  management  investment company.  The fund's investment objective is to
provide  investors  with  long-term capital growth, current income and growth of
income,  consistent  with  reasonable  investment risk.  The Dreyfus Corporation
(the  "Manager" ) serves  as  the  fund' s investment adviser.  The Manager is a
direct  subsidiary  of  Mellon  Bank,  N.A.  ("Mellon"), which is a wholly-owned
subsidiary  of Mellon Financial Corporation.  Premier Mutual Fund Services, Inc.
is  the distributor of the fund's shares, which are sold to the public without a
sales    charge.

The  fund' s  financial  statements  are  prepared  in accordance with generally
accepted accounting principles which may require the use of management estimates
and   assumptions.    Actual   results   could  differ  from  those  estimates.

(a)  Portfolio  valuation:  Investments  in  securities  (including  options and
financial futures) are valued at the last sales price on the securities exchange
on  which such securities are primarily traded or at the last sales price on the
national  securities  market.   Securities  not  listed  on  an  exchange or the
national  securities market, or securities for which there were no transactions,
are  valued  at  the average of the most recent bid and asked prices, except for
open short positions, where the asked price is used for valuation purposes.  Bid
price  is used when no asked price is available.  Securities for which there are
no  such  valuations  are valued at fair value as determined in good faith under
the  direction  of  the  Board of Directors.  Investments denominated in foreign
currencies  are  translated to U.S. dollars at the prevailing rates of exchange.
Forward   currency   exchange   contracts  are  valued  at  the  forward  rate.

(b) Foreign currency transactions: The fund does not isolate that portion of the
results  of  operations  resulting  from  changes  in  foreign exchange rates on
investments  from  the  fluctuations  arising  from  changes in market prices of
securities  held.   Such  fluctuations  are  included  with the net realized and
unrealized    gain    or    loss    from    investments.

                                                             The Fund

NOTES TO FINANCIAL STATEMENTS (CONTINUED)

Net realized foreign exchange gains or losses arise from sales and maturities of
short-term  securities,  sales  of  foreign currencies, currency gains or losses
realized  on  securities  transactions and the difference between the amounts of
dividends,  interest, and foreign withholding taxes recorded on the fund's books
and  the  U.S.  dollar equivalent of the amounts actually received or paid.  Net
unrealized  foreign exchange gains and losses arise from changes in the value of
assets  and  liabilities  other  than  investments in securities, resulting from
changes in exchange rates.  Such gains and losses are included with net realized
and    unrealized    gain    or    loss    on    investments.

(c)  Securities  transactions and investment income: Securities transactions are
recorded  on  a  trade  date  basis.   Realized  gain  and  loss from securities
transactions  are  recorded  on  the  identified cost basis.  Dividend income is
recognized  on  the  ex-dividend  date  and  interest  income,  including, where
applicable,  amortization  of  discount  on  investments,  is  recognized on the
accrual  basis.  Under the terms of the custody agreement, the fund receives net
earnings credits based on available cash balances left on deposit.

(d)  Dividends  to shareholders: Dividends are recorded on the ex-dividend date.
Dividends from investment income-net are declared and paid on a quarterly basis.
Dividends  from  net  realized  capital  gain  are  normally  declared  and paid
annually, but the fund may make distributions on a more frequent basis to comply
with  the  distribution  requirements  of  the Internal Revenue Code of 1986, as
amended  (the  "Code" ).  To  the  extent  that net realized capital gain can be
offset  by  capital loss carryovers, if any, it is the policy of the fund not to
distribute    such    gain.

(e) Federal income taxes: It is the policy of the fund to continue to qualify as
a  regulated  investment company, if such qualification is in the best interests
of  its  shareholders,  by complying with the applicable provisions of the Code,
and  to  make  distributions  of  taxable  income  sufficient to relieve it from
substantially    all    Federal    income    and     excise    taxes.


NOTE 2--Bank Lines of Credit:

The fund may borrow up to $10 million for leveraging purposes under a short-term
unsecured  line of credit and participates with other Dreyfus-managed funds in a
$100  million unsecured line of credit primarily to be utilized for temporary or
emergency purposes, including the financing of redemptions.  Interest is charged
to  the  fund  at rates which are related to the Federal Funds rate in effect at
the    time    of    borrowings.

The  average  daily  amount  of  borrowings  outstanding under both arrangements
during  the  period  ended October 31, 1999, was approximately $1,014,800 with a
related    weighted    average    annualized    interest    rate   of   5.25%

NOTE 3--Management Fee and Other Transactions  With Affiliates:

(a)  Pursuant  to a management agreement with the Manager, the management fee is
computed  at  the  annual  rate  of .75 of 1% of the value of the fund's average
daily    net    assets    and    is    payable    monthly.

(b)  Under  the  Shareholder  Services Plan, the fund reimburses Dreyfus Service
Corporation,  a  wholly-owned subsidiary of the Manager, an amount not to exceed
an  annual rate of .25 of 1% of the value of the fund's average daily net assets
for certain allocated expenses of providing personal services and/or maintaining
shareholder  accounts.   The  services  provided  may  include personal services
relating  to  shareholder  accounts,  such  as  answering  shareholder inquiries
regarding  the  fund  and  providing reports and other information, and services
related  to  the  maintenance  of shareholder accounts.  During the period ended
October  31,  1999,  the fund was charged $2,902,078 pursuant to the Shareholder
Services    Plan.

The  fund  compensates  Dreyfus Transfer, Inc., a wholly-owned subsidiary of the
Manager,   under  a  transfer  agency  agreement  for  providing  personnel  and
facilities   to   perform   transfer   agency   services   for   the   The  Fun

NOTES TO FINANCIAL STATEMENTS (CONTINUED)

fund.  During  the  period ended October 31, 1999, the fund was charged $942,956
pursuant    to    the    transfer    agency    agreement.

The  fund  compensates  Mellon under a custody agreement for providing custodial
services  for  the fund.  During the period ended October 31, 1999, the fund was
charged    $130,412    pursuant    to    the    custody    agreement.

(c)  Each  Director  who  is  not  an  "affiliated person" as defined in the Act
receives from the fund an annual fee of $4,500 and an attendance fee of $500 per
meeting.   The  Chairman  of  the  Board  receives  an  additional  25%  of such
compensation.

NOTE 4--Securities Transactions:

(a)  The  following  summarizes  the  aggregate amount of purchases and sales of
investment   securities   and   securities   sold  short,  excluding  short-term
securities,  financial  futures  and forward currency exchange contracts, during
the    period    ended    October    31,    1999:

                                      Purchases ($)               Sales ($)
- --------------------------------------------------------------------------------

Long transactions                     1,496,441,625           1,705,740,398

Short sale transactions                   1,905,504               1,648,777

     TOTAL                            1,498,347,129           1,707,389,175

The  fund  is  engaged  in short-selling which obligates the fund to replace the
security  borrowed by purchasing the security at current market value.  The fund
would  incur  a  loss if the price of the security increases between the date of
the  short  sale  and the date on which the fund replaces the borrowed security.
The  fund  would  realize  a  gain if the price of the security declines between
those  dates.   Until  the  fund  replaces  the borrowed security, the fund will
maintain daily, a segregated account with a broker and custodian, of permissible
liquid  assets  sufficient  to  cover  its short position.  At October 31, 1999,
there    were    no    securities    sold    short    outstanding.

The  fund  enters into forward currency exchange contracts in order to hedge its
exposure  to changes in foreign currency exchange rates on its foreign portfolio
holdings.   When  executing  forward  currency  exchange  contracts, the fund is
obligated  to  buy  or  sell a foreign currency at a specified rate on a certain
date    in    the    future.     With    respect    to

sales of forward currency exchange contracts, the fund would incur a loss if the
value  of the contract increases between the date the forward contract is opened
and  the  date  the forward contract is closed.  The fund realizes a gain if the
value  of the contract decreases between those dates.  With respect to purchases
of forward currency exchange contracts, the fund would incur a loss if the value
of  the  contract  decreases between the date the forward contract is opened and
the  date the forward contract is closed.  The fund realizes a gain if the value
of  the  contract  increases  between  those  dates. The fund is also exposed to
credit  risk  associated  with  counter  party  nonperformance  on these forward
currency exchange contracts which is typically limited to the unrealized gain on
each  open  contract.   At  October  31,  1999,  there  were no forward currency
exchange    contracts    outstanding.

The  fund may invest in financial futures contracts in order to gain exposure to
or protect against changes in the market.  The fund is exposed to market risk as
a  result  of  changes  in  the  value  of the underlying financial instruments.
Investments in financial futures require the fund to "mark to market" on a daily
basis,  which  reflects  the  change  in the market value of the contract at the
close  of  each  day' s  trading.   Accordingly,  variation  margin payments are
received  or  made  to  reflect  daily  unrealized  gains  or  losses.  When the
contracts  are  closed,  the  fund  recognizes  a  realized gain or loss.  These
investments  require  initial margin deposits with a custodian, which consist of
cash  or  cash equivalents, up to approximately 10% of the contract amount.  The
amount  of  these  deposits  is  determined by the exchange or Board of Trade on
which  the  contract  is  traded  and  is  subject to change.  Contracts open at
October  31,  1999  are  set  forth  in  the  Statement  of  Financial  Futures.

(b)  At October 31, 1999, accumulated net unrealized appreciation on investments
and  financial  futures  was  $291,853,126,  consisting  of  $311,901,124  gross
unrealized   appreciation   and   $20,047,998  gross  unrealized  depreciation.

At October 31, 1999, the cost of investments for Federal income tax purposes was
substantially  the  same  as  the cost for financial reporting purposes (see the
Statement    of    Investments)   .

                                                             The Fund

REPORT OF INDEPENDENT AUDITORS

Shareholders and Board of Directors Dreyfus Growth and Income Fund, Inc.

We  have audited the accompanying statement of assets and liabilities of Dreyfus
Growth  and  Income  Fund,  Inc.,  including  the  statements of investments and
financial  futures  as  of  October  31,  1999,  and  the  related  statement of
operations  for  the year then ended, the statement of changes in net assets for
each  of  the  two  years in the period then ended, and financial highlights for
each  of  the years indicated therein.  These financial statements and financial
highlights  are the responsibility of the Fund's management.  Our responsibility
is  to express an opinion on these financial statements and financial highlights
based    on    our    audits.

We   conducted  our  audits  in  accordance  with  generally  accepted  auditing
standards.  Those standards require that we plan and perform the audit to obtain
reasonable  assurance  about  whether  the  financial  statements  and financial
highlights are free of material misstatement.  An audit includes examining, on a
test  basis,  evidence  supporting  the amounts and disclosures in the financial
statements  and  financial  highlights.  Our procedures included verification by
examination  of  securities  held  by  the  custodian as of October 31, 1999 and
confirmation  of  securities  not  held  by the custodian by correspondence with
others.   An  audit  also  includes assessing the accounting principles used and
significant  estimates  made  by  management,  as well as evaluating the overall
financial  statement  presentation.   We  believe  that  our  audits  provide  a
reasonable    basis    for    our    opinion.

In  our  opinion,  the financial statements and financial highlights referred to
above  present  fairly,  in  all  material  respects,  the financial position of
Dreyfus  Growth  and  Income  Fund, Inc. at October 31, 1999, the results of its
operations  for  the  year then ended, the changes in its net assets for each of
the two years in the period then ended, and the financial highlights for each of
the   indicated   years,   in  conformity  with  generally  accepted  accounting
principles.

New York, New York December 1, 1999



IMPORTANT TAX INFORMATION (Unaudited)

For  Federal  tax  purposes,  the  fund  hereby designates $1.125 per share as a
long-term capital gain distribution of the $1.175 per share paid on December 11,
1998.

The fund also designates 43.90% of the ordinary dividends paid during the fiscal
year  ended  October 31, 1999 as qualifying for the corporate dividends received
deduction.   Shareholders  will  receive  notification  in  January  2000 of the
percentage applicable to the preparation of their 1999 income tax returns.



                                                             The Fund

NOTES

                                                           For More Information

                        Dreyfus Growth and Income Fund, Inc.

                        200 Park Avenue

                        New York, NY 10166

                        Manager

                        The Dreyfus Corporation

                        200 Park Avenue

                        New York, NY 10166

Custodian

Mellon Bank, N.A.

One Mellon Bank Center

Pittsburgh, PA 15258

Transfer Agent &

Dividend Disbursing Agent

Dreyfus Transfer, Inc.

P.O. Box 9671

Providence, RI 02940

Distributor

Premier Mutual Fund Services, Inc.

60 State Street

Boston, MA 02109

To obtain information:

BY TELEPHONE Call 1-800-645-6561

BY MAIL  Write to:  The Dreyfus Family of Funds 144 Glenn Curtiss Boulevard
Uniondale, NY 11556-0144

BY E-MAIL  Send your request to [email protected]

ON THE INTERNET  Information can be viewed online or downloaded from:

http://www.dreyfus.com

(c) 1999 Dreyfus Service Corporation                                  010AR9910





COMPARISON OF CHANGE IN VALUE OF $10,000 INVESTMENT
IN DREYFUS GROWTH AND INCOME FUND, INC. AND THE
STANDARD & POOR'S 500 COMPOSITE STOCK PRICE INDEX




           DREYFUS           STANDARD
          GROWTH AND       & POOR'S 500
 PERIOD     INCOME        COMPOSITE STOCK
          FUND, INC.       PRICE INDEX *

12/31/91       10,000               10,000
10/31/92       11,257               10,281
10/31/93       13,986               11,814
10/31/94       13,993               12,270
10/31/95       15,836               15,510
10/31/96       18,910               19,245
10/31/97       21,362               25,423
10/31/98       22,906               31,019
10/31/99       27,439               38,979

Source: Lipper Analytical Services, Inc.




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