DURA PHARMACEUTICALS INC/CA
4, 1998-01-12
PHARMACEUTICAL PREPARATIONS
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 4
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
( ) Check this box if no longer subject to Section 16.
Form 4 or Form 5 obligations may continue. See Instructions 1(b).
1. Name and Address of Reporting Person
   Garner, Cam L.
   c/o Dura Pharmaceuticals, Inc.
   7475 Lusk Blvd.
   San Diego, CA  92121
   USA
2. Issuer Name and Ticker or Trading Symbol
   Dura Pharmaceuticals, Inc.
   DURA
3. IRS or Social Security Number of Reporting Person (Voluntary)
   ###-##-####
4. Statement for Month/Year
   12-31-97
5. If Amendment, Date of Original (Month/Year)
   
6. Relationship of Reporting Person(s) to Issuer (Check all applicable)
   (X) Director ( ) 10% Owner (X) Officer (give title below) ( ) Other
   (specify below)
   Chairman, President & CEO
7. Individual or Joint/Group Filing (Check Applicable Line)
   (X) Form filed by One Reporting Person
   ( ) Form filed by More than One Reporting Person
<TABLE>
<CAPTION>
___________________________________________________________________________________________________________________________________
 Table I -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned                                                 |
___________________________________________________________________________________________________________________________________|
1. Title of Security       |2.    |3.    |4.Securities Acquired (A)         |5.Amount of        |6.Dir |7.Nature of Indirect       |
                           | Transaction |  or Disposed of (D)              |  Securities       |ect   |  Beneficial Ownership     |
                           |      |      |                                  |  Beneficially     |(D)or |                           |
                           |      |    | |                  | A/|           |  Owned at         |Indir |                           |
                           | Date |Code|V|    Amount        | D |    Price  |  End of Month     |ect(I)|                           |
___________________________________________________________________________________________________________________________________|
<S>                        <C>    <C>  <C><C>               <C> <C>         <C>                 <C>    <C>
___________________________________________________________________________________________________________________________________|
<CAPTION>
___________________________________________________________________________________________________________________________________
 Table II -- Derivative Securitites Acquired, Disposed of, or Beneficially Owned                                                   |
___________________________________________________________________________________________________________________________________|
1.Title of Derivative |2.Con-  |3.   |4.    |5.Number of De |6.Date Exer|7.Title and Amount  |8.Price|9.Number    |10.|11.Nature of|
  Security            |version |Transaction | rivative Secu |cisable and|  of Underlying     |of Deri|of Deriva   |Dir|Indirect    |
                      |or Exer |     |      | rities Acqui  |Expiration |  Securities        |vative |tive        |ect|Beneficial  |
                      |cise    |     |      | red(A) or Dis |Date(Month/|                    |Secu   |Securities  |(D)|Ownership   |
                      |Price of|     |      | posed of(D)   |Day/Year)  |                    |rity   |Benefi      |or |            |
                      |Deriva- |     |      |               |Date |Expir|                    |       |ficially    |Ind|            |
                      |tive    |     |      |           | A/|Exer-|ation|   Title and Number |       |Owned at    |ire|            |
                      |Secu-   |     |    | |           | D |cisa-|Date |   of Shares        |       |End of      |ct |            |
                      |rity    |Date |Code|V|  Amount   |   |ble  |     |                    |       |Month       |(I)|            |
___________________________________________________________________________________________________________________________________|
<S>                   <C>      <C>   <C>  <C><C>        <C> <C>   <C>   <C>          <C>     <C>     <C>          <C> <C>
Employee Stock Option |$44.88  |12-19|A   |V|125,000    |A  |12-19|12-19|Common Stock|125,000|       |125,000     |D  |            |
(right to buy)        |        |-97  |    | |           |   |-01* |-07  |            |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Warrants (right to buy|$54.84  |12-18|P   | |6,250      |A  |01-01|12-31|Common Stock|1,563  |$16.00(|6,250       |D  |            |
)(1)                  |        |-97  |    | |           |   |-00 (|-02  |            |       |3)     |            |   |            |
                      |        |     |    | |           |   |2)   |     |            |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Allocation from Compan|        |12-19|J(4)| |6,935      |A  |     |     |Common Stock|6,935  |       |6,935       |I  |(4)         |
y Deferred Compensatio|        |-97  |    | |           |   |     |     |            |       |       |            |   |            |
n Plan - Common Stock |        |     |    | |           |   |     |     |            |       |       |            |   |            |
(4)                   |        |     |    | |           |   |     |     |            |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Allocation from Co. De|$54.84  |12-22|J(5)| |50,630     |A  |01-01|12-31|Common Stock|12,658 |       |50,630      |I  |(5)         |
ferred Compensation Pl|        |-97  |    | |           |   |-00 (|-02  |            |       |       |            |   |            |
an -Warrants (right to|        |     |    | |           |   |2)   |     |            |       |       |            |   |            |
 buy) (5)             |        |     |    | |           |   |     |     |            |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Allocation from Co. De|$19.47  |12-19|J(6)| |7,219      |A  |12-19|12-29|Common Stock|17,326 |       |7,219       |I  |(6)         |
ferred Comp. Plan-Seri|        |-97  |    | |           |   |-97  |-00  |            |       |       |            |   |            |
es S Warrants (right t|        |     |    | |           |   |     |     |            |       |       |            |   |            |
o buy)(6)             |        |     |    | |           |   |     |     |            |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
                      |        |     |    | |           |   |     |     |            |       |       |            |   |            |
___________________________________________________________________________________________________________________________________|
</TABLE>
Explanation of Responses:
* Date option becomes fully vested.  Option vests daily from the grant date 
over a 4-year period.
(1)  Warrants were issued as a component of Units consisting of one share of 
Callable Common Stock of Spiros Development Corporation II, Inc. 
("SDCII") and one Warrant to purchase one-fourth of one share of Common Stock 
of the Issuer (the "Units").
(2)  Warrants are exercisable from 01-01-00 or until such earlier date as the 
purchase option held by the Issuer to purchase all outstanding Callable 
Common Stock of SDCII  is exercised or expires unexercised (the "Separation 
Date"), unless the the Separation Date is accelerated because of an 
Acceleration Event, in which case the Warrants become immediately 
exercisable.
(3)  The purchase price reflects the full purchase price of the Units described 
in Footnote (1) above and does not attempt to allocate the purchase 
price of the securities comprising the 
Units.
(4) Allocation (based upon participation and payroll deduction) of Common Stock 
of the Issuer received and held by the Trustee for the Company's 
Deferred Compensation Plan as a result of the Issuer's exercise of its purchase 
option to acquire all of the outstanding Callable Common Stock of 
Spiros Development Corporation ("SDCI").  Pursuant to the terms of its purchase 
option, the Issuer elected to pay the exercise price in shares of the 
Issuer's Common Stock.  Reporting person has no direct ownership in, and has no 
voting rights associated with, the Common Stock.
(5) Allocation (based upon participation and payroll deduction) of Warrants, 
which are a component of Units described in Footnote (1) above which 
were purchased and are held by the Trustee for the Company's Deferred 
Compensation Plan.   Source of funds for the purchase is the participant's 
contribution.  Reporting person has no direct ownership in, and has no voting 
rights associated with, the Warrants, which are a component of the 
Units.
(6) Allocation (based upon participation and payroll deduction) of Series S 
Warrants of the Issuer received and held by the Trustee for the Company's 
Deferred Compensation Plan as a result of the Issuer's acquisition of its 
purchase option to acquire all of the outstanding Callable Common Stock of 
SDCI.  Reporting person has no direct ownership in, and no voting rights 
associated with, the Series S Warrants.
SIGNATURE OF REPORTING PERSON
/s/ Cam L. Garner
DATE
January  9, 1998



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