DURA PHARMACEUTICALS INC
DEF 14A, 1998-04-16
PHARMACEUTICAL PREPARATIONS
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                            SCHEDULE 14A INFORMATION
 
                  Proxy Statement Pursuant to Section 14(a) of
            the Securities Exchange Act of 1934 (Amendment No.    )
 
    Filed by the Registrant /X/
    Filed by a Party other than the Registrant / /
 
    Check the appropriate box:
    / /  Preliminary Proxy Statement
    / /  Confidential, for Use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
    /X/  Definitive Proxy Statement
    / /  Definitive Additional Materials
    / /  Soliciting Material Pursuant to Section 240.14a-11(c) or Section 
         240.14a-12
 
                          DURA PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
 
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
/X/  No fee required.

/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) 
     and 0-11.

    (1) Title of each class of securities to which transaction applies:

        ------------------------------------------------------------------------
    (2) Aggregate number of securities to which transaction applies:

        ------------------------------------------------------------------------
    (3) Per unit price or other underlying value of transaction computed
        pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
        filing fee is calculated and state how it was determined):

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    (4) Proposed maximum aggregate value of transaction:

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    (5) Total fee paid:

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/ / Fee paid previously with preliminary materials.

/ / Check box if any part of the fee is offset as provided by Exchange Act Rule
    0-11(a)(2) and identify the filing for which the offsetting fee was paid
    previously. Identify the previous filing by registration statement number,
    or the Form or Schedule and the date of its filing.

    (1) Amount Previously Paid:

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    (2) Form, Schedule or Registration Statement No.:

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    (3) Filing Party:

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    (4) Date Filed:

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<PAGE>



                                        [LOGO]




                              DURA PHARMACEUTICALS, INC.
                                   7475 LUSK BLVD.
                             SAN DIEGO, CALIFORNIA  92121



                                    April 16, 1998



Dear Stockholder:

     You are cordially invited to attend the Annual Meeting of Stockholders of
Dura Pharmaceuticals, Inc., which will be held at the La Jolla Marriott, 4240 La
Jolla Village Drive, La Jolla, California, on Thursday, May 21, 1998 at 10:00
a.m.

     Details of the business to be conducted at the Annual Meeting are given in
the attached Notice of Annual Meeting of Stockholders and Proxy Statement.

     In order for us to have an efficient meeting, please sign, date and return
the enclosed proxy promptly in the accompanying reply envelope.  If you are able
to attend the Annual Meeting and wish to change your proxy vote, you may do so
simply by voting in person at the Annual Meeting.

     We look forward to seeing you at the Annual Meeting.

                                             Sincerely,

                                             /s/ Cam L. Garner


                                             CAM L. GARNER
                                             CHAIRMAN, PRESIDENT AND
                                             CHIEF EXECUTIVE OFFICER



- --------------------------------------------------------------------------------
                                YOUR VOTE IS IMPORTANT

     In order to assure your representation at the meeting, you are
     requested to complete, sign and date the enclosed proxy as promptly as
     possible and return it in the enclosed envelope.  No postage need be
     affixed if mailed in the United States.
- --------------------------------------------------------------------------------
<PAGE>

                                        [LOGO]




                              DURA PHARMACEUTICALS, INC.
                                   7475 LUSK BLVD.
                             SAN DIEGO, CALIFORNIA 92121

                       NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                                     MAY 21, 1998

     The Annual Meeting (the "Annual Meeting") of Stockholders of Dura
Pharmaceuticals, Inc. (the "Company") will be held at the La Jolla Marriott,
4240 La Jolla Village Drive, La Jolla, California, on Thursday, May 21, 1998 at
10:00 a.m., for the following purposes:

     1.   To elect five (5) directors to serve two-year terms to expire at the
          Annual Meeting of Stockholders in 2000.

     2.   To approve an amendment to the Company's Certificate of Incorporation
          to increase the authorized number of shares of Common Stock of the
          Company from 100,000,000 to a total of 200,000,000 shares.

     3.   To approve an amendment to the Company's 1992 Stock Option Plan to
          increase the authorized number of shares of Common Stock available for
          issuance under the Option Plan.

     4.   To ratify the appointment of Deloitte & Touche LLP as the Company's
          independent public accountants for the fiscal year ending December 31,
          1998.

     5.   To transact any other business which may properly come before the
          meeting or any adjournment(s) thereof.

     Stockholders of record at the close of business on March 23, 1998 will be
entitled to vote at the Annual Meeting.  A list of stockholders entitled to vote
at the Annual Meeting will be available for inspection at the offices of the
Company.  Whether or not you plan to attend the meeting in person, please sign,
date and return the enclosed proxy in the reply envelope provided.  If you
attend the Annual Meeting and vote by ballot, your proxy will be revoked
automatically and only your vote at the Annual Meeting will be counted.  The
prompt return of your proxy will assist us in preparing for the Annual Meeting.

                                        By Order of the Board of Directors

                                        /s/ Mitchell R. Woodbury

Dated:  April 16, 1998                  MITCHELL R. WOODBURY
                                        SENIOR VICE PRESIDENT, GENERAL COUNSEL
                                        AND SECRETARY

<PAGE>

                              DURA PHARMACEUTICALS, INC.
                                   PROXY STATEMENT



                            ANNUAL MEETING OF STOCKHOLDERS
                               TO BE HELD MAY 21, 1998





     These proxy materials and the enclosed proxy card are being mailed in
connection with the solicitation of proxies by the Board of Directors of Dura
Pharmaceuticals, Inc., a Delaware corporation (the "Company"), for the Annual
Meeting of Stockholders (the "Annual Meeting") to be held at 10:00 a.m. on May
21, 1998 and at any adjournment or postponement of the Annual Meeting.  These
proxy materials were first mailed to stockholders of record beginning on
approximately April 16, 1998.

     The mailing address of the principal executive office of the Company is
7475 Lusk Blvd., San Diego, California 92121.

                                  PURPOSE OF MEETING

     The specific proposals to be considered and acted upon at the Annual
Meeting are summarized in the accompanying Notice of Annual Meeting of
Stockholders.  Each proposal is described in more detail in this Proxy
Statement.


                            VOTING RIGHTS AND SOLICITATION

     Any stockholder executing a proxy has the power to revoke it at any time
before it is voted by delivering written notice of such revocation to the
Secretary of the Company before the Annual Meeting or by properly executing and
delivering a proxy bearing a later date.  Proxies may also be revoked by any
stockholder present at the Annual Meeting who elects to vote his or her shares
in person.  The cost of soliciting proxies will be paid by the Company and may
include reimbursement paid to brokerage firms and others for their expense in
forwarding solicitation material.  Solicitation will be made primarily through
the use of the mail, but regular employees of the Company may, without
additional remuneration, solicit proxies personally by telephone, telegram or
facsimile.

     The record date for determining those stockholders who are entitled to
notice of, and to vote at, the Annual Meeting has been fixed as March 23, 1998
(the "Record Date").  At the close of business on the Record Date, the Company
had 46,185,361 outstanding shares of common stock, $.001 par value per share
(the "Common Stock"), and no shares of preferred stock, $.001 par value per
share (the "Preferred Stock").  Each stockholder is entitled to one vote on
matters brought before the Annual Meeting for each share of Common Stock held by
the stockholder at the Record Date.  Cumulative voting is not permitted.  Both
abstentions and broker non-votes are counted as present for the purpose of
determining the presence or absence of a quorum for the transaction of business.
For purposes of determining the number of shares voting on a particular
proposal, abstentions are counted as shares voting, whereas broker non-votes are
not counted as shares voting.  Thus, broker non-votes can have the effect of
preventing approval of certain proposals where the number of affirmative votes,
though a majority of the votes cast, does not constitute a majority of the
required quorum.  ChaseMellon Shareholder Services, the Company's transfer
agent, will tabulate the votes.

<PAGE>

                                      PROPOSAL 1

                                ELECTION OF DIRECTORS

     The Board of Directors of the Company is currently composed of nine
members.  The Company's Certificate of Incorporation divides the Board into two
classes of directors serving staggered two-year terms, with one class of
directors to be elected at each annual meeting of stockholders.  All of the
nominees are now serving as directors of the Company.  Unless individual
stockholders specify otherwise, each returned proxy will be voted for the
election of Messrs. Cook, Garner and Hale and Drs. Blair and Kabakoff, who have
each agreed to stand for election to hold office for a term of two years,
expiring at the Annual Meeting of Stockholders in 2000, or until a successor is
elected and has qualified.  The five candidates receiving the highest number of
affirmative votes by holders of Common Stock represented and voting at the
Annual Meeting will be elected directors of the Company.

     If, however, any of those named are unable to serve, or for good cause
decline to serve at the time of the Annual Meeting, the persons named in the
enclosed proxy will exercise discretionary authority to vote for substitutes.
The Board of Directors is not aware of any circumstances that would render any
nominee unavailable for election.

               THE COMPANY'S BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
                        A VOTE FOR THE NOMINEES LISTED HEREIN.

NOMINEES FOR ELECTION TO TERMS WHICH EXPIRE AT THE ANNUAL MEETING OF
STOCKHOLDERS IN 2000

     James C. Blair, Ph.D., 58, has served as a general partner of Domain
Associates, a venture capital management company, since 1985. Dr. Blair was
first elected director of the Company in 1986 and currently serves as a member
of both the Company's Compensation Committee and Audit Committee.  Dr. Blair is
currently a director of Amylin Pharmaceuticals, Inc.  ("Amylin"), Aurora
Biosciences Corp., CoCensys Inc., Gensia Sicor Inc. ("Gensia"), Trega
Biosciences, Inc. ("Trega"), all biopharmaceutical companies, and Vista Medical
Technologies, Inc., a medical device company.

     Joseph C. Cook, Jr., 56, has been Chairman and Chief Executive Officer of
Amylin since March 1998.  He has also been President of Cambrian Associates, LLC
since 1994 and has been a principal of Life Science Advisors, LLC ("Life Science
Advisors") since it was founded in 1994.  Mr. Cook retired as Group Vice
President, Global Manufacturing, Engineering and Corporate Quality at Eli Lilly
and Company ("Lilly") in 1993.  During his 28 years with Lilly, Mr. Cook was
Vice President of Sales and Marketing, Chief Financial Officer for Elanco
Products Company, and General Manager of a worldwide business unit of Lilly.
Mr. Cook joined the Company's Board of Directors in 1995 and currently serves as
a member of the Company's Audit Committee.  He is currently a director of
Amylin, NABI, Inc., a biopharmaceutical company, and Personnel Management, Inc.,
a temporary services company.

     Cam L. Garner, 50, joined the Company in 1989 as Executive Vice President
of the Company (formerly Immunetech Pharmaceuticals), President of the Company's
former subsidiary and a director.  He has served as President and Chief
Executive Officer of the Company since 1990 and was named Chairman of the Board
in 1995.  Prior to joining the Company, Mr. Garner served as President of Syntro
Corporation, a biotechnology company, from 1987 to 1989.  Mr. Garner is
currently a director of Safeskin Corporation, a manufacturer of medical
supplies, Trega, Spiros Development Corporation II, Inc. ("Spiros Corp. II"), a
developer of pulmonary drug delivery systems, and CardioDynamics International
Corporation, a manufacturer of medical devices.  Mr. Garner received an MBA from
Baldwin-Wallace College and a B.S. in Biology from Virginia Wesleyan College.

     David F. Hale, 49, has served as President and Chief Executive Officer of
Women First Health Care, Inc. since February 1998.  He served as President and
Chief Executive Officer of Gensia from 1987 until 1997 and as Chairman from 1991
to 1997.  Prior to joining Gensia, Mr. Hale was President and Chief Executive
Officer of Hybritech Incorporated ("Hybritech"), a biotechnology company which
was acquired by Lilly in 1986.  Mr. Hale was first elected director of the
Company in 1986 and currently serves as a member of the Company's Compensation
Committee.


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<PAGE>

     David S. Kabakoff, Ph.D., 50, joined the Company in 1996 as a director and
Executive Vice President, and currently also serves as a director, Chairman,
President and Chief Executive Officer of Spiros Corp. II.  He served as
President and Chief Executive Officer of Spiros Development Corporation ("Spiros
Corp.") from 1996 to 1997, prior to the Company's exercise of its purchase
option to acquire all of the outstanding stock of Spiros Corp.  From 1989 to
1996, he was employed by Corvas International, Inc., a biopharmaceutical
company, and served in a number of capacities during that time period, including
Chief Executive Officer, President, Chief Operating Officer and Chairman of the
Board.  From 1983 to 1989, Dr. Kabakoff was employed by Hybritech, most recently
as Senior Vice President of Research and Development-Diagnostics.  He received a
Ph.D. in Organic Chemistry from Yale University and a B.A. in Chemistry from
Case Western  Reserve University.

DIRECTORS WHOSE TERMS EXPIRE AT THE ANNUAL MEETING OF STOCKHOLDERS IN 1999

     Herbert J. Conrad, 65, served as President of the Pharmaceuticals Division
and Senior Vice President of Hoffmann-LaRoche Inc. ("Roche") from 1982 until his
retirement in 1993.  Mr. Conrad joined Roche in 1960 and held various positions,
including Senior Vice President of the Pharmaceuticals Division, Chairman of the
Board of Medi-Physics, Inc. and Vice President, Public Affairs and Planning
Division.  Mr. Conrad was first elected director of the Company in 1994 and
currently serves as a member of the Company's Compensation Committee.  Mr.
Conrad is a director of Gensia, Biotechnology General Corp., a biotechnology
company, and UroCor, Inc., a urological diagnostics and therapeutics company.

     Gordon V. Ramseier, 53, has been Executive Director of a private consulting
company, The Sage Group, since 1995.  The Sage Group provides consulting
services to companies in the health care field.  Mr. Ramseier has operated a
private consulting company since 1994, and also performed such consulting work
from 1990 to 1992.  Mr. Ramseier served as President and Chief Executive Officer
of Onco Therapeutics, Inc. from 1992 until 1994.  From 1986 to 1990,
Mr. Ramseier served as President and Chief Executive Officer of the Company.
Mr. Ramseier was first elected director of the Company in 1986 and currently
serves as a member of the Company's Audit Committee.

     Charles G. Smith, Ph.D., 70, has operated a private consulting company
since 1986 and is currently a consultant for several health care companies.
Prior to his consulting work, Dr. Smith served with Revlon Health Care Group as
Vice President of Research and Development from 1975 to 1986.  Dr. Smith was
first elected director of the Company in 1988 and also serves as a member of the
Company's Scientific Advisory Board.

     Walter F. Spath, 53, joined the Company in 1988 and currently serves as
Senior Vice President, Sales and Marketing, and has served as a director since
1991.  Prior to joining the Company, Mr. Spath was Corporate Vice President,
Commercial Development, at Searle Pharmaceuticals ("Searle") from 1986 to 1988,
where he also served in a variety of sales and marketing positions from 1975 to
1986.  Prior to joining Searle, Mr. Spath was a marketing manager at Pfizer Inc.
Mr. Spath received an MBA in Marketing from the University of Maryland and a
B.S. in Economics from Villanova.

BOARD MEETINGS AND COMMITTEES

     The Company's Board of Directors met a total of nine times and took action
by unanimous written consent a total of 13 times during the fiscal year ended
December 31, 1997.  With the exception of Mr. Conrad, each director attended at
least 75% of the aggregate of (i) the total meetings of the Board of Directors
(held during the period for which he has been a director) and (ii) the total
number of meetings held by all committees of the board on which he served
(during the periods that he served).   Mr. Conrad attended 70% of the aggregate
total of such meetings and was advised of all activity associated with meetings
he did not attend.

     The Company has a standing Compensation Committee currently composed of
three non-employee directors:  Dr. Blair, Mr. Conrad and Mr. Hale.  The
Compensation Committee met once and took action by unanimous written consent a
total of three times in fiscal 1997.  The Compensation Committee reviews and
acts on matters relating to compensation levels and benefit plans for executive
officers and key employees of the Company, including salary and stock options.
The Committee is also responsible for granting stock awards, stock options,
stock appreciation rights, and other awards to be made under the Company's
existing incentive compensation plan.  The Company also has a standing Audit
Committee currently composed of the following three non-employee directors:  Dr.
Blair, Mr. Cook and Mr. Ramseier.  During fiscal 1997, the Audit Committee met
once.  The Audit Committee assists in selecting the independent auditors,
designating


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<PAGE>

services they are to perform and maintaining effective communication with those
auditors.  The Company does not have a standing Nominating Committee or any
other committee performing similar functions, as such matters are considered at
meetings of the full Board of Directors.


                                      PROPOSAL 2

                        APPROVAL OF AMENDMENT TO THE COMPANY'S
                             CERTIFICATE OF INCORPORATION

     On February 19, 1998, the Company's Board of Directors approved an
amendment, subject to stockholder approval, to the Company's Certificate of
Incorporation (the "Certificate") in order to increase the number of authorized
shares of Common Stock of the Company from 100,000,000 to 200,000,000 shares.

     Pursuant to Article IV(A) of the Certificate, the Company is currently
authorized to issue 100,000,000 shares of Common Stock and 5,000,000 shares of
Preferred Stock.  If the proposed amendment is approved, the authorized number
of shares of Common Stock will increase to 200,000,000.  As of March 23, 1998,
there were 46,185,361 shares of Common Stock outstanding, and an additional
8,832,644 shares of Common Stock have been reserved for issuance upon the
exercise of stock options and warrants.  No shares of Preferred Stock were
outstanding.

     If this proposal is adopted by the Company's stockholders, paragraph (A) of
Article IV of the Company's Certificate will read as follows:

          (A)  CLASSES OF STOCK.  The corporation is authorized to issue two
     classes of stock, denominated Common Stock and Preferred Stock.  The Common
     Stock shall have a par value of $.001 per share and the Preferred Stock
     shall have a par value of $.001 per share. The total number of shares of
     Common Stock which the corporation is authorized to issue is Two Hundred
     Million (200,000,000), and the total number of shares of Preferred Stock
     which the corporation is authorized to issue is Five Million (5,000,000),
     which shares of Preferred Stock shall be undesignated as to series.

     The proposed increase in the number of shares of authorized Common Stock
will ensure that shares will be available, if needed, for issuance in connection
with stock splits, stock dividends, financings, acquisitions and other corporate
purposes.  The Board of Directors believes that the availability of the
additional shares for such purposes without delay or the necessity for a special
stockholders' meeting would be beneficial to the Company.  The Company does not
have any immediate plans, arrangements, commitments or understandings with
respect to the issuance of any of the additional shares of Common Stock which
would be authorized by the proposed amendment.

     No further action or authorization by the Company's stockholders would be
necessary prior to the issuance of the additional shares of Common Stock unless
required by applicable law or regulatory agency or by the rules of any stock
exchange on which the Company's securities may then be listed.  The National
Association of Securities Dealers, Inc. requires stockholder approval as a
prerequisite to continued inclusion of the shares on the Nasdaq National Market
in certain situations.

     The proposed increase in the authorized number of shares of Common Stock
could have a number of effects on the Company's stockholders depending upon the
exact nature and circumstances of any actual issuances of authorized but
unissued shares.  The increase could have an anti-takeover effect, in that
additional shares could be issued (within the limits imposed by applicable law)
in one or more transactions that could make a change in control or takeover of
the Company more difficult.  For example, additional shares could be issued by
the Company so as to dilute the stock ownership or voting rights of persons
seeking to obtain control of the Company.  Similarly, the issuance of additional
shares to certain persons allied with the Company's management could have the
effect of making it more difficult to remove the Company's current management by
diluting the stock ownership or voting rights of persons seeking to cause such
removal.  In addition, an issuance of additional shares by the Company could
have an effect on the potential realizable value of a stockholder's investment.
In the absence of a proportionate increase in the Company's earnings and book
value, an increase in the


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aggregate number of outstanding shares of the Company caused by the issuance of
additional shares would dilute the earnings per share and book value per share
of all outstanding shares of the Company's Common Stock.  If such factors were
reflected in the price per share of Common Stock, the potential realizable value
of a stockholder's investment could be adversely affected.

     The holders of any of the additional shares of Common Stock issued in the
future would have the same rights and privileges as the holders of the shares of
Common Stock currently authorized and outstanding.  Those rights do not include
preemptive rights with respect to the future issuance of any additional shares.
The proposed amendment to the Company's Certificate will not otherwise alter or
modify the rights, preferences, privileges or restrictions of the Common stock.

     The affirmative vote of the holders of a majority of the outstanding shares
of Common Stock at the Record Date is necessary to approve an amendment to the
Company's Certificate.

                THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE
        FOR THE APPROVAL OF THE AMENDMENT TO THE CERTIFICATE OF INCORPORATION.


                                      PROPOSAL 3

                        APPROVAL OF AMENDMENT TO THE COMPANY'S
                                1992 STOCK OPTION PLAN


GENERAL

     The stockholders are being asked to vote on an amendment to the Company's
1992 Stock Option Plan (the "Option Plan"), which amendment was approved by the
Board of Directors on February 19, 1998, subject to stockholder approval.  The
effect of the amendment will be to increase the number of shares available for
issuance under the Option Plan by an additional 1,000,000 shares to a total of
8,607,360 shares.  The affirmative vote of a majority of the shares of Common
Stock represented and voting at the Annual Meeting is required for approval of
the amendment to the Option Plan.  The Option Plan, as amended, will become
effective immediately upon approval by the stockholders at the Annual Meeting.

     Prior to the amendment, 7,607,360 shares were available for issuance under
the Option Plan.  The amendment to increase the shares available for issuance
was adopted by the Board principally as a result of the public offerings by the
Company of (a) $287.5 million principal amount of 3 1/2% Convertible
Subordinated Notes due July 15, 2002 which were issued in July 1997, and (b)
Warrants to purchase shares of Common Stock which are a component of Units
offered by Spiros Corp. II and the Company which were issued in December 1997.
An additional 7,259,140 shares of Common Stock may be issued upon conversion or
exercise, respectively, of such securities.  The Board's intention is to retain
approximately the same proportion of shares subject to the Option Plan in
relation to the number of shares outstanding.

SUMMARY OF STOCK OPTION PLAN

     The following is a summary of all material terms and provisions of the
Option Plan, assuming the amendment discussed above is adopted.  The summary,
however, does not purport to be a complete description of all of the provisions
of the Option Plan.  Copies of the actual Option Plan documents may be obtained
by any stockholder upon written request to the Secretary of the Company at the
corporate offices in San Diego, California.

     OPTION PLAN ADMINISTRATION.  The Option Plan is administered by a committee
or committees (the "Committee") appointed by the Board from among its members
(the "Option Plan Administrator").  Administration of the Option Plan with
respect to persons subject to Section 16 of the Securities Exchange Act of 1934,
as amended (the "Exchange Act"), will comply with the applicable requirements of
Rule 16b-3.  The Option Plan Administrator is generally authorized to construe
and interpret the Option Plan, to establish appropriate rules and regulations,
to select key employees, consultants and independent contractors of the Company
and its subsidiaries for participation, and to specify the terms of the options
granted under the Option Plan.  Members of a Committee may be removed by the
Board.  The Company will pay all costs of administration of the Option Plan. The
cash proceeds received by the Company from the issuance of shares pursuant to
the Option Plan will be used for general corporate purposes.


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<PAGE>

     SHARE RESERVE.  The aggregate number of shares available for issuance under
the Option Plan may not exceed 8,607,360 shares of Common Stock, subject to
adjustment from time to time in the event of certain changes to the Company's
capital structure.

     Should any option under the Option Plan expire or terminate prior to
exercise or surrender in full (including any option incorporated into the Option
Plan from the Company's prior stock option plans), the shares subject to the
portion of the option not so exercised or surrendered will be available for
subsequent option grants.  Shares subject to any option surrendered or cancelled
in accordance with the option surrender or cash-out provisions of the Option
Plan will NOT be available for subsequent grants.

     ELIGIBILITY.  The persons eligible to receive discretionary stock options
include all employees of the Company or its subsidiaries, non-employee members
of the Board or the board of directors of any subsidiary, and consultants and
other independent advisors who provide services to the Company or its
subsidiary.  Only non-employee members of the Board will be eligible to receive
automatic option grants.  As of January 31, 1998, seven executive officers, six
non-employee Board members, and approximately 642 other employees were eligible
to participate in the Option Plan, and the six non-employee Board members were
also eligible to participate in the automatic option grant program.

     VALUATION.  The fair market value per share of Common Stock on any relevant
date under the Option Plan will be the closing selling price per share on that
date on the Nasdaq National Market.  On March 2, 1998, the closing selling price
of the Company's Common Stock was $25.00 per share.

     PER-EMPLOYEE LIMITATION.  No more than 1,500,000 shares may be granted to
any one optionee over the lifetime of the Option Plan and no more than 400,000
shares may be granted to any one optionee in any fiscal year.

     REPURCHASE RIGHTS.  The Committee may include as an option term that the
Company (or its assigns) will have the right, exercisable on the optionee's
separation from service, to repurchase Common Stock acquired by the optionee
upon the exercise of an option.  The Committee may also provide for the
automatic termination of such a repurchase right.

     GRANTS.  Under the general terms of the Option Plan, the Committee may
grant either an incentive stock option ("ISO"), which satisfies the requirements
of Section 422 of the Internal Revenue Code of 1986, as amended (the "Code"), or
a non-qualified option ("NQO"), which is not intended to satisfy the
requirements of Section 422 of the Code.  The Committee may also determine the
number of shares of Common Stock issuable under an option as well as the
exercise date, the exercise price, and the exercise period of an option.  The
duration of an option may not exceed ten years, and the exercise price for
options may not be less than the fair market value (as defined in the Option
Plan) of the Common Stock on the date of grant of the option, provided that the
Option Plan Administrator may fix the exercise price at less than 100% of the
fair market value to the extent that the optionee has made a payment to the
Company at the time of the grant of the option (including by means of a salary
reduction agreement) equal to the amount by which the fair market value exceeds
the exercise price.

     Upon exercise, the price of an option is generally payable in full in cash.
In the Committee's discretion, the purchase price may be paid: (i) in shares of
the Company's Common Stock ("Previously Owned Shares") held for such period of
time as may be required in order to avoid a charge to the Company's earnings;
(ii) by means of a same-day sale program, pursuant to which a designated
brokerage firm immediately sells shares purchased under the option and pays over
to the Company, out of the sales proceeds available on the settlement date,
funds to cover the option price plus all applicable withholding taxes; or (iii)
by means of a promissory note.  The Committee may also permit an optionee to
elect to have any withholding tax obligation paid through withholding of shares
or by delivery of Previously Owned Shares.  In order to assist an optionee
(other than the recipient of an Automatic Grant, as hereinafter defined) in the
acquisition of Common Stock pursuant to an option, the Committee may also
authorize the Company to extend secured or unsecured credit, in an amount
sufficient to cover the exercise price and any employment tax liability incurred
upon exercise of the option, to an optionee who is also an employee.

     During the lifetime of an optionee, an ISO is exercisable only by the
optionee and is not assignable or transferable other than by will or by the laws
of descent and distribution following the optionee's death.  However, an NQO may
be assigned in whole or in part during the optionee's lifetime.  The terms
applicable to the assigned portion are the same as those in effect for the
option immediately prior to such assignment.


                                          6
<PAGE>

     AUTOMATIC GRANTS.  Each person who is newly elected or appointed as a
non-employee director after the effective date of the Option Plan will receive,
on the date of such election or appointment, an NQO for 30,000 shares of Common
Stock.  On the date of each of the Company's Annual Meetings, each person who
(i) (A) is a continuing non-employee director or (B) is re-elected at the Annual
Meeting and (ii) has served as a non-employee director for the immediately
preceding 180 days, will receive an  NQO for 8,000 shares of Common Stock
(collectively, the "Automatic Grant").

     The exercise price of each Automatic Grant will be equal to the fair market
value of the Common Stock on the date of grant. The exercise price of an
Automatic Grant will be payable in cash or in Common Stock held for such period
of time as may be required to avoid a charge to the Company's earnings or by
means of a same day sale program, pursuant to which a designated brokerage firm
immediately sells shares purchased under the Automatic Grant and pays over to
the Company, out of the sales proceeds available on the settlement date, funds
to cover the option price plus all applicable employment taxes.  The term of the
Automatic Grant will be ten years.  The Automatic Grant will become fully
exercisable one year after the grant date (or immediately upon a Corporate
Transaction as described below).  Finally, the Automatic Grant will be granted
in tandem with a limited stock appreciation right as described below.  Options
granted under the Automatic Grant program will expire if not exercised within 6
months after the optionee ceases to serve as a director or within 12 months
after the optionee ceases to serve as a director due to the optionee's death.

     ACCELERATION OF OPTIONS.  In the event of any of the following transactions
to which the Company is a party (a "Corporate Transaction"):

     (i)  a merger or consolidation in which the Company is not the surviving
     entity (except for a transaction the principal purpose of which is to
     change the state of the Company's incorporation),

     (ii)  the sale, transfer or other disposition of all or substantially all
     of the assets of the Company in complete liquidation or dissolution of the
     Company,

     (iii)  a reverse merger in which the Company is the surviving entity but in
     which the holders of securities possessing more than 50% of the combined
     voting power of the Company's outstanding securities (as determined
     immediately prior to such merger) transfer their ownership of those
     securities to a person or persons not otherwise part of the transferor
     group, or

     (iv)  a tender or exchange offer made directly to the Company's
     stockholders in which any person or related group of persons (other than
     the Company or any affiliate) acquires beneficial ownership of securities
     possessing more than 50% of the combined voting power of the Company's
     outstanding securities,

each outstanding option will automatically become exercisable for all of the
option shares and may be exercised for any or all of such shares.  The Company's
outstanding repurchase rights under the Option Plan will also terminate, and the
shares subject to such terminated rights will become fully vested, upon the
Corporate Transaction.  Upon the consummation of the Corporate Transaction, all
outstanding options under the Option Plan will terminate and cease to be
exercisable, except to the extent assumed by the successor corporation.

     The acceleration of options in the event of a Corporate Transaction may be
seen as an anti-takeover provision and may have the effect of discouraging a
merger proposal, a takeover attempt or other efforts to gain control of the
Company.

     TERMINATION OF SERVICE.  Upon the optionee's cessation of employment or
service, the optionee will have a limited period of time in which to exercise
his or her outstanding options for any shares in which the optionee is vested at
that time.  However, at any time while the options remain outstanding, the Plan
Administrator will have complete discretion to extend the period following the
optionee's cessation of employment or service during which his or her
outstanding options may be exercised.  The Plan Administrator will also have
complete discretion to accelerate the exercisability or vesting of those options
in whole or in part at any time.

     CANCELLATION/REGRANT PROGRAM.  The Plan Administrator will have the
authority to effect the cancellation of outstanding options which have exercise
prices in excess of the then current market price of the Common Stock and to
issue replacement options with an exercise price based on the market price of
Common Stock at the time of the new grant.  Automatic Grants are not subject to
the cancellation and regrant provisions.


                                          7
<PAGE>

     STOCK APPRECIATION RIGHTS.  The Option Plan includes a stock appreciation
rights program, pursuant to which one or more optionees may, subject to
Committee approval, surrender their outstanding options in return for a payment
from the Company in an amount equal to the excess of (i) the fair market value
(on the option surrender date) of the shares of Common Stock subject to the
surrendered option over (ii) the aggregate option price payable for such shares.
The payment may, at the discretion of the Committee, be made either in cash or
in shares of Common Stock.

     One or more officers of the Company subject to the short-swing profit
restrictions of the federal securities laws may, in the Committee's discretion,
be granted limited stock appreciation rights in tandem with their outstanding
options.  In addition, all Automatic Grants will be made in tandem with the
grant of a limited stock appreciation right.  Any option with such a limited
stock appreciation right in effect for at least six months will automatically be
cancelled upon the occurrence of a Hostile Takeover (as defined below), and the
optionee will in return be entitled to a cash distribution from the Company in
an amount equal to the excess of (i) the Takeover Price of the shares of Common
Stock at the time subject to the cancelled option (whether or not the option is
otherwise at the time exercisable for such shares) over (ii) the aggregate
exercise price payable for such shares.

     For purposes of these option cancellation provisions, the following
definitions are in effect under the Option Plan:

          A Hostile Takeover shall be deemed to occur upon the acquisition by
     any person or related group of persons (other than the Company or a person
     that directly or indirectly controls, is controlled by, or is under common
     control with, the Company) of ownership of more than 50% of the Company's
     outstanding Common Stock (excluding the Common Stock holdings of officers
     and directors of the Company who participate in this Option Plan) pursuant
     to a tender or exchange offer which the Board does not recommend the
     Company's stockholders accept.

          The Takeover Price per share shall be deemed to be equal to the
     GREATER of (a) the Fair Market Value per share on the date of cancellation,
     or (b) the highest reported price per share paid in effecting the Hostile
     Takeover.  However, if the cancelled option is an ISO, the Takeover Price
     shall not exceed the clause (a) price per share.

     AMENDMENT AND TERMINATION OF THE OPTION PLAN.  The Board may amend, suspend
or discontinue the Option Plan at any time.  Stockholder approval of amendments
to the Option Plan will be required when the amendments are made conditional on
such approval by the Board or when such approval is required by law or
regulation.  Generally, the provisions of the Option Plan concerning Automatic
Grants may only be amended once every six months.  The Option Plan will
terminate December 8, 2002 unless sooner terminated by the Board.

FEDERAL INCOME TAX CONSEQUENCES

     The following is a general description of certain federal income tax
consequences of the Option Plan.  This description does not purport to be
complete.

     The Company will be entitled to a business expense deduction equal to the
ordinary income recognized by an optionee on exercise of an NQO.  The ordinary
income recognized will be equal to the excess of the fair market value of the
purchased shares on the date of recognition over the exercise price.  Generally,
the date of recognition will be the date the option is exercised or, if later,
the first date shares acquired on exercise are not subject to a substantial risk
of forfeiture.

     The Company will also be entitled to a business expense deduction equal to
the ordinary income recognized by an optionee due to a "disqualifying
disposition" of stock acquired pursuant to an ISO.  A disqualifying disposition
occurs if an optionee disposes of the acquired shares within two years of the
date of the option grant, or within one year of the date the shares are acquired
by the optionee.  In the case of a disqualifying disposition, the optionee will
generally recognize ordinary income in the year of disposition, in an amount
equal to the amount of ordinary income the optionee would have recognized from
the exercise of the option had the option been an NQO at the time of exercise.

     To the extent that the aggregate fair market value (determined as of the
respective date or dates of grant) of shares with respect to which options that
would otherwise be ISOs are exercisable for the first time by any individual
during any calendar year exceeds the sum of $100,000, such options will be
treated as NQOs.


                                          8
<PAGE>

     If the exercisability of an option is accelerated as a result of a change
in control of the Company, all or a portion of the value of the option at that
time may be a "parachute" payment for purposes of the Code's "excess parachute"
provisions. Those provisions generally provide that if "parachute" payments
exceed three times an employee's average compensation for the five tax years
preceding the change in control, the Company loses its deduction and the
recipient is subject to a 20% excise tax for the amount of the "parachute"
payments in excess of such average compensation.

     An optionee who surrenders an outstanding option for a cash or stock
distribution from the Company will recognize ordinary income in the year of
surrender equal to the amount of the appreciation distribution.  The Company
will be entitled to a corresponding business expense deduction for the
appreciation distribution.  The deduction will be allowed in the taxable year of
the Company in which the ordinary income is recognized by the optionee.

     On the date an ISO is exercised or, if later, the date shares acquired upon
exercise are not subject to a substantial risk of forfeiture, the optionee will
generally recognize alternative minimum taxable income in an amount equal to the
excess of the fair market value of the purchased shares over the exercise price.
An optionee's recognition of alternative minimum taxable income will have no
effect on the Company.

ACCOUNTING TREATMENT

     Pursuant to the accounting policy selected by the Company, neither the
grant of options to employees nor the exercise of any options will result in any
charge to the Company's earnings.  The grant of options to non-employees will
result in a charge to earnings equal to the fair market value of the options at
the date of grant.  The number of outstanding options under the Option Plan will
be a factor in determining earnings per share.

     Should one or more optionees be granted the unqualified right to surrender
their options under the Option Plan for a cash or stock distribution,
compensation expense will arise as a charge to the Company's earnings.
Accordingly, at the end of each fiscal quarter, the amount (if any) by which the
fair market value of the shares of Common Stock subject to each such
surrenderable option has increased from prior quarter-end will be accrued as
compensation expense, to the extent such amount is in excess of the aggregate
exercise price payable for such shares.  In the event the fair market value of
such shares declines from quarter to quarter, appropriate adjustments to current
compensation expense will be made.


                                          9
<PAGE>

OUTSTANDING OPTION GRANTS UNDER THE OPTION PLAN

     The following table shows, as to the Company's Chairman, President and
Chief Executive Officer and each of the other four most highly compensated
executive officers of the Company (collectively, the "Named Executive Officers")
and as to the various indicated groups, information with respect to stock
options granted during all Option Plan years through February 28, 1998.

                        OPTIONS GRANTED UNDER THE OPTION PLAN

<TABLE>
<CAPTION>
                                                                     All Option Plan Years Through 2-28-98
                                                                     -------------------------------------
                                                                      Number of              Weighted Average
                                                                       Options               Exercise Price
                                                              -----------------------  --------------------------
     <S>                                                      <C>                      <C>
     Cam L. Garner                                                 1,130,000 (1)                 $10.91
     Director, Chairman, President, Chief Executive
     Officer and nominee for Director

     David S. Kabakoff                                               290,000 (1)                 $31.41
     Director, Executive Vice President,
     and nominee for Director

     Walter F. Spath                                                 445,000 (1)                 $ 9.53
     Director and Senior Vice President,
     Sales and Marketing

     James W. Newman                                                 365,000 (1)                 $15.06
     Senior Vice President, Finance and
     Administration, and Chief Financial Officer

     Charles W. Prettyman                                            295,000 (1)                 $11.54
     Senior Vice President,
     Development and Regulatory Affairs

     All current non-employee directors who are not                  513,000 (2)                 $11.60
     executive officers as a group (6 persons)

     All current executive officers as a group                     2,930,000 (1)                 $14.34
     (7 persons)

     All employees who are not executive officers                  3,512,986 (1)                 $14.41
     as a group
 </TABLE>
- --------------------

(1)  Includes options granted to the following individuals or groups which were
     originally granted in 1996 and which were cancelled and regranted in April
     1997 as follows:  Mr. Garner, 150,000 shares; Dr. Kabakoff, 20,000 shares;
     Mr. Spath, 40,000 shares; Mr. Newman, 40,000 shares; Mr. Prettyman, 35,000
     shares; all current executive officers as a group, 355,000 shares; and all
     employees who are not executive officers, 416,275 shares.  See discussion
     concerning the option cancellation/regrant program contained in "Executive
     Compensation and Other Information -- Ten-Year Information Regarding
     Repricing, Cancellation and Regrant of Options" and "Board Compensation
     Committee Report on Executive Compensation -- Compensation Committee Report
     on 1997 Cancellation and Regrant of Options."
(2)  Includes an option to purchase 100,000 shares of Common Stock granted to
     Life Science Advisors, of which Mr. Cook is a principal, pursuant to a
     consulting arrangement between Life Science Advisors and the Company.  See
     "Executive Compensation and Other Information -- Director Compensation."


                                          10
<PAGE>

     As of February 28, 1998, options covering 3,712,207 shares of Common Stock
were outstanding under the Option Plan, 1,705,746 shares remained available for
future option grants (assuming stockholder approval of the increase which forms
part of this proposal), and 3,189,407 shares have been issued pursuant to the
exercise of outstanding options under the Option Plan.

NEW OPTION PLAN BENEFITS

     Effective as of the 1998 Annual Meeting, the amendment will increase the
number of shares authorized for issuance under the Option Plan by 1,000,000
shares to a total of 8,607,360 shares.  None of the 1,000,000-share increase has
been granted prior to the date of the Annual Meeting.

VOTE REQUIRED FOR APPROVAL OF THE AMENDMENT TO THE OPTION PLAN

     The affirmative vote of the holders of a majority of the shares of Common
Stock represented and voting at the Annual Meeting is necessary to approve the
amendment to the Option Plan.

                THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE
                FOR THE APPROVAL OF THE AMENDMENT TO THE OPTION PLAN.


                                      PROPOSAL 4


                RATIFICATION OF APPOINTMENT OF INDEPENDENT ACCOUNTANTS

     The Company is asking the stockholders to ratify the selection of Deloitte
& Touche LLP as the Company's independent public accountants for the year ending
December 31, 1998.  In the event that the stockholders fail to ratify the
appointment, the Board of Directors will reconsider its selection.  Even if the
selection is ratified, the Board of Directors, in its discretion, may direct the
appointment of a different independent accounting firm at any time during the
year if the Board of Directors feels that such a change would be in the
Company's and the stockholders' best interest.

     A representative of Deloitte & Touche LLP is expected to be present at the
Annual Meeting to respond to questions and will have the opportunity to make a
statement if he or she desires to do so.

     The affirmative vote of the holders of a majority of shares of Common Stock
represented and voting at the Annual Meeting will be required to ratify the
selection of Deloitte & Touche LLP.

                    THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
                    A VOTE FOR THE RATIFICATION OF THE APPOINTMENT
                               OF DELOITTE & TOUCHE LLP
                      AS THE COMPANY'S INDEPENDENT ACCOUNTANTS.


                                          11
<PAGE>

                                PRINCIPAL STOCKHOLDERS

     The following are the only persons known by the Company to beneficially own
more than five percent of the outstanding shares of its Common Stock as of
January 31, 1998.

<TABLE>
<CAPTION>
                                                     Shares Beneficially Owned
                                                  ------------------------------
                  Name and Address
                  of Beneficial Owner                Number (1)      Percent (2)
        ----------------------------------------- --------------- --------------
        <S>                                       <C>             <C>
          Putnam Investments, Inc. (3)              6,054,813          13.2%
          One Post Office Square
          Boston, Massachusetts  02109


          Pilgrim Baxter & Associates, Ltd. (4)     4,303,390           9.4%
          825 Duportail Road
          Wayne, Pennsylvania  19087
</TABLE>
- ------------------------------------

(1)  Except as indicated in the footnotes to this table, the entities named in
     the table have sole voting and investment power with respect to all shares
     of Common Stock shown as beneficially owned by them.
(2)  Percentage of ownership is calculated pursuant to SEC Rule 13d-3(d)(1).
(3)  Pursuant to Amendment No. 1 to Schedule 13G dated January 16, 1998 filed by
     Putnam Investments, Inc., a parent holding company and a wholly-owned
     subsidiary of Marsh & McLennan Companies, Inc., and certain of its
     affiliates, which are investment advisers under the Investment Advisers Act
     of 1940, as amended (an "Investment Adviser").  Such entities reported
     shared voting and dispositive power as to these shares.
(4)  Pursuant to Amendment No. 3 to Schedule 13G dated January 20, 1998 filed by
     Pilgrim Baxter & Associates, Ltd., an Investment Adviser, which reported
     sole voting power as to 3,509,390 shares and shared voting power as to
     4,303,390 shares, and sole dispositive power as to all shares.


                                          12
<PAGE>

                         COMMON STOCK OWNERSHIP OF MANAGEMENT

     The following table sets forth the beneficial ownership of shares of Common
Stock of the Company as of January 31, 1998, by each director and nominee, each
Named Executive Officer, and by directors and executive officers as a group.
The address for each beneficial owner listed below is 7475 Lusk Blvd., San
Diego, California  92121.

<TABLE>
<CAPTION>
                                                    Shares Beneficially Owned
                                           -------------------------------------
                Name                           Number (1)(2)       Percent (3)
        ---------------------------------  -------------------  ----------------
        <S>                                <C>                  <C>
          James C. Blair (4)                     262,900                *

          Herbert J. Conrad                       16,000                *

          Joseph C. Cook, Jr. (5)                100,000                *

          Cam L. Garner                           94,371                *

          David F. Hale                           18,000                *

          David S. Kabakoff                      115,424                *

          James W. Newman                        101,957                *

          Charles W. Prettyman                    17,657                *

          Gordon V. Ramseier                      50,000                *

          Charles G. Smith                        62,000                *

          Walter F. Spath                        107,098                *

          Directors and executive              1,026,304                2.2%
          officers as a group
          (13 persons)
</TABLE>
- ----------------------

*Less than 1%
(1)  Except as indicated in the footnotes to this table, the persons named in
     the table have sole voting and investment power with respect to all shares
     of Common Stock shown as beneficially owned by them, subject to community
     property laws, where applicable.
(2)  Share ownership in each case includes shares issuable upon exercise of
     outstanding options, now exercisable or exercisable within 60 days of
     January 31, 1998 to purchase shares of Common Stock for the following
     persons or group:  Dr. Blair, 8,000; Mr. Conrad, 16,000; Mr. Cook, 38,000;
     Mr. Garner, 73,806; Mr. Hale, 18,000; Dr. Kabakoff, 113,356; Mr. Newman,
     86,229; Mr. Prettyman, 17,657; Mr. Ramseier, 50,000; Dr. Smith, 62,000; Mr.
     Spath, 106,370; and directors and executive officers as a group, 677,095.
(3)  Percentage of ownership is calculated pursuant to SEC Rule 13d-3(d)(1).
(4)  Includes 240,000 shares of Common Stock which may be acquired upon the
     exercise of Series S Warrants, now exercisable or exercisable within 60
     days, held by Domain Partners III, LP and DP Associates, LP.  Dr. Blair is
     one of several general partners of (a) the sole general partner of Domain
     Partners III, LP and (b) the sole general partner of DP III Associates, LP.
     Dr. Blair disclaims beneficial ownership of any securities, and any
     proceeds thereof, that exceed his pecuniary interest therein, and/or that
     are not actually distributed to him.
(5)  Includes options, now exercisable or exercisable within 60 days, to
     purchase 10,000 shares of Common Stock held by Life Science Advisors.  As a
     principal of Life Science Advisors, Mr. Cook may be deemed to be the
     indirect beneficial owner of shares held by Life Science Advisors.  Mr.
     Cook disclaims beneficial ownership of any securities, and  any proceeds
     thereof, that exceed his pecuniary interest therein, and/or that are not
     actually distributed to him.


                                          13
<PAGE>

                                  EXECUTIVE OFFICERS

     The Company's executive officers as of January 31, 1998 are:

     Name                     Age       Position Held With the Company
     ----                     ---       ------------------------------

     Julia Brown              50        Senior Vice President, Business
                                        Development

     Cam L. Garner            50        Chairman, President, Chief Executive
                                        Officer and director

     David S. Kabakoff        50        Executive Vice President and director

     James W. Newman          53        Senior Vice President, Finance and
                                        Administration, Chief Financial Officer
                                        and Assistant Secretary

     Charles W. Prettyman     52        Senior Vice President, Development and
                                        Regulatory Affairs

     Walter F. Spath          53        Senior Vice President, Sales and
                                        Marketing, and director

     Mitchell R. Woodbury     56        Senior Vice President, General Counsel
                                        and Secretary

     Messrs. Garner and Spath and Dr. Kabakoff are directors of the Company.
See "Election of Directors" for a discussion of each individual's business
experience.

     Julia Brown joined the Company in March 1995 as Vice President, Business
Planning, became Vice President, Business Development in October 1995 and was
named Senior Vice President in January 1997.  Prior to joining the Company, Ms.
Brown spent over 25 years with Lilly and certain subsidiaries dealing with
pharmaceuticals, medical devices and diagnostics.  From October 1992 to December
1994, she was general manager of IVAC Corporation's Vital Signs Division.  From
September 1986 to October 1992, Ms. Brown held several marketing positions with
Hybritech, including Division Vice President of Marketing.  Ms. Brown holds a
B.S. in Microbiology from Louisiana Tech University.

     James W. Newman joined the Company in September 1991 as Vice President,
Finance and Administration, and Chief Financial Officer and was named Senior
Vice President in February 1996.  Prior to joining the Company, Mr. Newman
served as President of George Wimpey of Texas and previously as Vice President
and Chief Financial Officer of George Wimpey, Inc., a land development and
home-building company, from October 1987 to September 1991.  Mr. Newman holds an
MBA in Finance from Golden Gate University and a B.S. in Accounting from the
University of Illinois.  Mr. Newman has been a Certified Public Accountant in
California since 1972.

     Charles W. Prettyman joined the Company in December 1991 as Vice President,
Development and Regulatory Affairs and was named Senior Vice President in
February 1996.  Prior to joining the Company, Mr. Prettyman served as Vice
President, Regulatory Affairs and Compliance at The Purdue Frederick Company, a
privately-held pharmaceutical company, from August 1988 to November 1991.  From
January 1988 until August 1988, Mr. Prettyman served as Executive Director, Drug
Regulatory Affairs, Central Nervous System Development at Ciba-Geigy
Pharmaceuticals.  From January 1977 until December 1987, Mr. Prettyman held
various positions with the United States Food and Drug Administration, including
Director, Program Management, Office of the Commissioner.  Mr. Prettyman
received an M.S. in Biological Science from George Washington University and a
B.S. degree in Biology from Randolph Macon College.

     Mitchell R. Woodbury joined the Company in June 1994 as Vice President,
General Counsel and Secretary and was named Senior Vice President in January
1997.  Prior to joining the Company, Mr. Woodbury served as Vice President,
General Counsel and Secretary at Advanced Tissue Sciences, Inc., a biomedical
company.  From October 1991 until June 1992, Mr. Woodbury served as Senior Vice
President and General Counsel of Intermark, Inc., a publicly held
operating/holding company.  He was elected Vice President and Corporate Counsel
of Intermark in 1980 and had served as Corporate Secretary since 1981.  Mr.
Woodbury received his J.D. from the University of San Diego School of Law and a
B.A. in Business Administration from San Diego State University.


                                          14
<PAGE>

                     EXECUTIVE COMPENSATION AND OTHER INFORMATION

SUMMARY OF CASH AND CERTAIN OTHER COMPENSATION

     The following table provides certain summary information concerning the
compensation earned by the Named Executive Officers for services rendered in all
capacities to the Company for the fiscal years ended December 31, 1997, 1996 and
1995.

                              SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                                       Long-Term
                                                                                      Compensation
                                                 Annual Compensation                    Awards
                                      --------------------------------------------- ---------------

                                                                                        Number of
                                                                                      Securities         All Other
        Name and                                                  Other Annual        Underlying      Compensation
   Principal Position          Year     Salary (1)   Bonus (1)  Compensation (2)     Options/SARs         (3)(4)
   ------------------          ----     ----------   ---------  ----------------     ------------      ------------
<S>                           <C>      <C>          <C>         <C>                  <C>               <C>
Cam L. Garner                 1997      $396,519    $475,000        $   --               275,000(5)      $31,540
Chairman, President and       1996      $347,654    $610,000        $   --                20,000         $21,093
Chief Executive Officer       1995      $337,391    $175,000        $   --                25,000         $ 5,610

David S. Kabakoff (6)         1997      $266,019       (7)          $   --                60,000(5)      $10,406
Executive Vice President      1996      $171,635    $105,000        $   --               230,000         $ 3,466

Walter F. Spath               1997      $210,808    $140,000        $   --                90,000(5)      $12,687
Senior Vice President,        1996      $201,538    $190,000        $   --                  -0-          $ 7,006
Sales and Marketing           1995      $204,250    $ 40,000        $   --                15,000         $ 3,750


James W. Newman               1997      $200,769    $140,000        $   --               110,000(5)      $14,677
Senior Vice President,        1996      $190,039    $190,000        $   --                20,000         $11,378
Finance and Administration,   1995      $175,870    $ 40,000        $   --                15,000         $ 4,406
and Chief Financial Officer


Charles W. Prettyman          1997      $191,116       (7)          $   --                65,000(5)      $   -0-
Senior Vice President,        1996      $179,577    $190,000        $   --                20,000         $   -0-
Development and Regulatory    1995      $167,700    $ 45,000        $   --                 7,500         $   -0-
Affairs
</TABLE>
- -----------------------------

(1)  Includes amounts deferred under the Company's 401(k) Profit Sharing Plan
     (the "401(k) Plan") pursuant to Section 401(k) of the Code and the
     Company's Deferred Compensation Plan (the "Deferred Comp. Plan").
(2)  Perquisites and other personal benefits paid to the Named Executive
     Officers are less than the minimum reporting threshold of $50,000 or 10% of
     the total annual salary plus bonus for the Named Executive Officer, and
     such amounts paid, if any, are represented in the table by "--".
(3)  Includes contributions made by the Company pursuant to the 401(k) Plan
     which were earned by the participants for the 1997, 1996 and 1995 fiscal
     years, respectively, and which were used to purchase shares of the
     Company's Common Stock as follows:  Mr. Garner $6,650, $6,750, and $3,750;
     Dr. Kabakoff $6,650, $3,150, and $0; Mr. Spath $6,650, $6,750, and $3,750;
     and Mr. Newman $6,650, $6,750, and $3,750.
(4)  Includes above-market interest earned by the participants on their Deferred
     Comp. Plan account for the 1997, 1996 and 1995 fiscal years, respectively,
     as follows:  Mr. Garner $24,890, $14,343 and $1,860; Dr. Kabakoff $3,756,
     $316 and $0; Mr. Spath $6,037, $256 and $0; and Mr. Newman $8,027, $4,628
     and $656.


                                          15
<PAGE>

(5)  Includes the following option as to each individual which was originally
     granted in December 1996 and which was cancelled and regranted in April
     1997, as follows:  Mr. Garner, 150,000 shares; Dr. Kabakoff, 20,000 shares;
     Mr. Spath, 40,000 shares; Mr. Newman, 40,000 shares, and Mr. Prettyman,
     35,000 shares.  See "Executive Compensation and Other Information -- Ten
     Year Information Regarding Repricing, Cancellation and Regrant of Options."
(6)  Dr. Kabakoff joined the Company in May 1996.
(7)  Bonuses were paid in November 1997 by Spiros Corp., a separate company, to
     Dr. Kabakoff and Mr. Prettyman in the amounts of $150,000 and $140,000,
     respectively.  Dura exercised its purchase option to acquire all of the
     callable common stock of  Spiros Corp. in December 1997.


                                          16
<PAGE>

STOCK OPTIONS

     The following table contains information concerning the grant of stock
options under the Company's Option Plan to the Named Executive Officers.  No
stock appreciation rights ("SARs") were granted under the Option Plan to the
Named Executive Officers in fiscal year ended December 31, 1997.


                    OPTION/SAR GRANTS IN LAST FISCAL YEAR

<TABLE>
<CAPTION>
                                          Individual Grants
- --------------------------------------------------------------------------------------------------
                                                                                                        Potential Realizable
                            Number of          Percent of                                                 Value at Assumed
                           Securities            Total                                                 Annual Rates of Stock
                           Underlying         Options/SARs                                             Price Appreciation for
                            Options/           Granted to          Exercise or                              Option Term
                              SARs            Employees in         Base Price       Expiration      ---------------------------
        Name               Granted (1)       Fiscal Year (2)      ($/Share) (3)      Date (4)         5% (5)           10% (5)
- ----------------------  -----------------  -------------------  -----------------  --------------  -----------------------------
<S>                     <C>                <C>                  <C>                <C>             <C>                <C>
Cam L. Garner               150,000(6)            8.34%              $25.00          4-25-07        $2,358,355       $5,976,534
                            125,000               6.95%              $44.88         12-19-07        $3,527,706       $8,939,899

David S. Kabakoff            20,000(6)            1.11%              $25.00          4-25-07        $  314,447       $  796,871
                             40,000               2.22%              $44.88         12-19-07        $1,128,866       $2,860,768

Walter F. Spath              40,000(6)            2.22%              $25.00          4-25-07        $  628,895       $1,593,742
                             50,000               2.78%              $44.88         12-19-07        $1,411,082       $3,575,960

James W. Newman              40,000(6)            2.22%              $25.00          4-25-07        $  628,895       $1,593,742
                             70,000               3.89%              $44.88         12-19-07        $1,975,515       $5,006,344

Charles W. Prettyman         35,000(6)            1.94%              $25.00          4-25-07        $  550,283       $1,394,525
                             30,000               1.66%              $44.88         12-19-07        $  846,649       $2,145,576
</TABLE>
- --------------------

(1)  Each option becomes exercisable ratably over a four-year period.  The
     Option Plan provides for acceleration of outstanding options in the event
     of certain corporate transactions, including a merger, sale, or change of
     control.
(2)  The Company granted options to acquire 1,797,950 shares of Common Stock to
     the Company's directors, officers and employees in 1997, of which options
     to acquire 771,725 shares of Common Stock were granted pursuant to the
     option cancellation/regrant program discussed in "Executive Compensation
     and Other Information -- Ten-Year Information Regarding Repricing,
     Cancellation and Regrant of Options" and "Board Compensation Committee
     Report on Executive Compensation -- Compensation Committee Report on 1997
     Cancellation and Regrant of Options."
(3)  The exercise price per share of options granted represented the fair market
     value of the underlying shares of Common Stock on the dates the respective
     options were granted.  The exercise price may be paid in cash or in shares
     of Common Stock valued at fair market value on the exercise date or a
     combination of cash or shares or any other form of consideration approved
     by the Board of Directors.
(4)  Each option has a term of ten years from the date of grant.  Options which
     expire 4-25-07 were granted 4-25-97 and options which expire 12-19-07 were
     granted 12-19-97.
(5)  There is no assurance provided to any executive officer or any other holder
     of the Company's securities that the actual stock price appreciation over
     the 10-year option term will be at the assumed 5% and 10% levels or at any
     other defined level.  Unless the market price of the Common Stock does in
     fact appreciate over the option term, no value will be realized from the
     option grants made to the executive officers.
(6)  Options granted in 1996 which were cancelled and regranted in 1997 pursuant
     to the option cancellation/regrant program discussed in "Executive
     Compensation and Other Information -- Ten-Year Information Regarding
     Repricing, Cancellation and Regrant of Options" and "Board Compensation
     Committee Report on Executive Compensation -- Compensation Committee Report
     on 1997 Cancellation and Regrant of Options."


                                          17
<PAGE>

OPTION EXERCISES AND HOLDINGS

     The following table provides information, with respect to the Named
Executive Officers, concerning the exercise of options pursuant to the Option
Plan during the fiscal year ended December 31, 1997 and unexercised options held
as of the end of the fiscal year.


              AGGREGATE OPTION/SAR EXERCISES IN LAST FISCAL YEAR
                    AND FISCAL YEAR-END OPTION/SAR VALUES

<TABLE>
<CAPTION>

                                                                     Number of Securities            Value of Unexercised
                                                                    Underlying Unexercised               in-the-Money
                                 Shares                                Options/SARs at                  Options/SARs at
                                Acquired                              December 31, 1997              December 31, 1997 (1)
                                  Upon               Value      -------------------------------  --------------------------------
        Name                    Exercise           Realized       Exercisable    Unexercisable    Exercisable    Unexercisable
        ----                    --------           --------       -----------    -------------    -----------    -------------
<S>                             <C>               <C>           <C>              <C>             <C>             <C>
Cam L. Garner                    118,460          $4,245,429          8,297         365,643       $  331,007       $6,461,912

David S. Kabakoff                   0                  0             87,996         202,004       $1,429,495       $2,764,354

Walter F. Spath                   50,000          $2,061,250         89,088         115,912       $3,513,179       $1,769,445

James W. Newman                   46,700          $1,930,893         50,909         161,991       $2,121,130       $2,681,108

Charles W. Prettyman              29,442          $  956,330          2,504          91,824       $   83,783       $1,634,892
</TABLE>
- -------------------------------

(1)  Value is defined as market price of the Company's Common Stock at fiscal
     year end less exercise price.  The market price of the Company's Common
     Stock at December 31, 1997 was $45.88.


DIRECTOR COMPENSATION

     The Company does not presently pay fees to its directors, other than
reimbursement for their out-of-pocket expenses incurred in attending meetings of
the Board of Directors and its committees.  In addition, each non-employee
director is entitled to receive options under the Option Plan in connection with
his service on the Board of Directors.  Each person who is newly elected or
appointed as a non-employee director after the effective date of the Option Plan
will receive, on the date of such election or appointment, a non-qualified
option for 30,000 shares of Common Stock.  On the date of each of the Company's
Annual Meetings, each person who (i) (A) is a continuing non-employee director
or (B) is re-elected at the Annual Meeting and (ii) has served as a non-employee
director for the immediately preceding 180 days, will receive a  non-qualified
stock option for 8,000 shares of Common Stock (collectively, the "Automatic
Grant").  The exercise price for the options is the fair market value of the
Common Stock on the date of grant and each option has a term of 10 years.
Automatic Grants are granted in tandem with limited stock appreciation rights
which become effective in the event of a Hostile Takeover.

     The Company entered into a one-year Consulting Agreement with Mr. Conrad in
April 1995, pursuant to which Mr. Conrad provided certain consulting services to
the Company related to marketing and licensing strategies, and for which Mr.
Conrad received compensation of $1,000 per month, plus reimbursement of
out-of-pocket expenses.  Such agreement has been extended for subsequent
one-year terms and currently expires March 31, 1999.

     The Company engaged Life Science Advisors, of which Mr. Cook is a
principal, in May 1995 to provide certain strategic consulting services on a
limited basis, for which it received compensation during the 1997 fiscal year of
$27,860, plus reimbursement of out-of-pocket expenses.


                                          18
<PAGE>

TEN-YEAR INFORMATION REGARDING REPRICING, CANCELLATION AND REGRANT OF OPTIONS

     As discussed in "Board Compensation Committee Report on Executive
Compensation -- Compensation Committee Report on 1997 Cancellation and Regrant
of Options," the Company implemented an option cancellation/regrant program for
executive officers and all other employees holding stock options granted during
the period from August 22, 1996 through April 25, 1997.  The
cancellation/regrant was effected April 25, 1997 and each option held by those
individuals granted during the period from August 22, 1996 through April 25,
1997, at such individual's election, was cancelled in exchange for a new option
for the same number of shares with an exercise price of $25.00 per share, the
fair market value of the Common Stock on April 25, 1997.  Vesting on the
underlying option was forfeited and the replacement option vests over a new
4-year period commencing April 25, 1997 and remains valid for a 10-year term.

     The Compensation Committee determined that this program was necessary
because equity incentives are a significant component of the total compensation
of each employee and play a substantial role in the Company's ability to retain
the services of the individuals essential to the Company's long-term financial
success.  Prior to implementation of the program, the market price of the Common
Stock had fallen and did not necessarily reflect the progress made by the
Company in financing operations, product acquisitions, research and development
programs and collaborative programs.  The Compensation Committee felt that the
Company's ability to retain key employees would be significantly impaired unless
value was restored in the form of regranted options for the Common Stock at the
then current market price.


                                          19
<PAGE>

     The following table sets forth information with respect to each executive
officer of the Company who held an option which was subject to an option
repricing program during the last ten fiscal years ended December 31, 1997.  The
table details his or her participation in the option cancellation/regrant
program which was effected April 25, 1997.


                        TEN-YEAR OPTION/SAR REPRICINGS
                                     1997

<TABLE>
<CAPTION>

                                                                                                                       Length of
                                             Number of                                                                 Original
                                             Securities                                                               Option Term
                                             Underlying      Market Price of     Exercise Price                      Remaining at
                                            Options/SARs     Stock at Time of      at Time of            New            Date of
                                            Repriced or        Repricing or       Repricing or         Exercise      Repricing or
             Name                Date       Amended (#)       Amendment ($)       Amendment ($)       Price ($)        Amendment
             ----                ----       ------------      -------------       -------------       ---------        ---------
 <S>                            <C>         <C>              <C>                 <C>                  <C>            <C>
 Julia Brown                    4-25-97        40,000             $25.00             $37.63             $25.00        9 1/2 years
 Senior Vice President,
 Business Development

 Cam L. Garner                  4-25-97       150,000             $25.00             $37.63             $25.00        9 1/2 years
 Chairman, President &
 Chief Executive Officer

 David S. Kabakoff              4-25-97        20,000             $25.00             $37.63             $25.00        9 1/2 years
 Executive Vice President

 James W. Newman                4-25-97        40,000             $25.00             $37.63             $25.00        9 1/2 years
 Senior Vice President,
 Finance and Administration,
 and Chief Financial Officer

 Charles W. Prettyman           4-25-97        35,000             $25.00             $37.63             $25.00        9 1/2 years
 Senior Vice President,
 Development and
 Regulatory Affairs

 Walter F. Spath                4-25-97        40,000             $25.00             $37.63             $25.00        9 1/2 years
 Senior Vice President,
 Sales and Marketing

 Mitchell R. Woodbury           4-25-97        30,000             $25.00             $37.63             $25.00        9 1/2 years
 Senior Vice President,
 General Counsel &
 Corporate Secretary
</TABLE>
 
     An aggregate of 355,000 options originally granted December 6, 1996 under
the Option Plan to the executive officers were cancelled and regranted under the
April 25, 1997 cancellation/regrant program.  The option cancellation/regrant
program was conducted in accordance with the terms and conditions of the Option
Plan.

     See "Board Compensation Committee Report on Executive Compensation --
Compensation Committee Report on 1997 Cancellation and Regrant of Options" for a
further discussion regarding stock options which were cancelled and regranted
during the 1997 fiscal year.


                                          20
<PAGE>

EMPLOYMENT CONTRACTS AND CHANGE OF CONTROL ARRANGEMENTS

     In May 1990, the Company entered into an employment agreement with Mr.
Garner pursuant to which he was employed as President and Chief Executive
Officer.  The current employment term ends May 31, 1998, and will automatically
renew for successive one-year periods, unless either Mr. Garner or the Company
elect otherwise.  The agreement allows for termination of employment upon
Mr. Garner's death or disability and for cause or without cause upon 60 days'
written notice.  During the employment term, Mr. Garner will receive an annual
base salary (currently $395,000) subject to increase by the Company's Board of
Directors annually, with a minimum increase of at least 5%.

     In the event of termination of employment by the Company without cause, the
Company is obligated to pay Mr. Garner six months' base salary.  Mr. Garner is
entitled to nine months' base salary if there has been a change of control of
the Company and he is terminated without cause, or following: (i) a change in
position with the Company that materially reduces Mr. Garner's level of
responsibility; (ii) a 10% or more reduction of Mr. Garner's compensation; or
(iii) a change in Mr. Garner's place of employment to more than 20 miles from
the Company's current facility in San Diego, California, unless Mr. Garner
otherwise agrees in writing.

     In May 1996, Dr. Kabakoff entered into an employment agreement with the
Company upon substantially the same terms and conditions as described above for
Mr. Garner, with an initial term expiring April 30, 1998.  Dr. Kabakoff's
current annual base salary is $265,000 and is subject to annual review and
increase at the sole discretion of the Board of Directors.


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     In fiscal 1997, Dr. Blair and Messrs. Conrad and Hale served as the members
of the Company's Compensation Committee.  The Company has no insider
relationships reportable pursuant to this item.



     NOTWITHSTANDING ANYTHING TO THE CONTRARY SET FORTH IN ANY OF THE COMPANY'S
     PREVIOUS OR FUTURE FILINGS UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR
     THE EXCHANGE ACT THAT MIGHT INCORPORATE FUTURE FILINGS, INCLUDING THIS
     PROXY STATEMENT, IN WHOLE OR IN PART, THE FOLLOWING BOARD COMPENSATION
     COMMITTEE REPORT ON EXECUTIVE COMPENSATION AND THE PERFORMANCE GRAPH
     INCLUDED HEREIN SHALL NOT BE INCORPORATED BY REFERENCE INTO ANY SUCH
     FILINGS.

BOARD COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

        GENERAL COMPENSATION POLICY.  The fundamental policy of the Company is
     to offer the executive officers competitive compensation opportunities
     based upon their contribution to the financial success of the Company and
     their personal performance.  It is our objective to have a substantial
     portion of each officer's compensation contingent upon the Company's
     performance, as well as upon his or her own level of performance.
     Accordingly, each executive officer's compensation package is comprised of
     three elements: (i) base salary which reflects individual performance and
     is designed primarily to be competitive with salary levels in the industry,
     (ii) annual variable performance awards payable in cash and tied to the
     achievement of financial and individual performance goals established by
     management and approved by the Board of Directors, and (iii) long-term
     stock-based incentive awards which strengthen the mutuality of interests
     between the executive officers and the Company's stockholders.  As an
     officer's level of responsibility increases, it is our intent to have a
     greater portion of his or her total compensation be dependent upon Company
     performance and stock price appreciation rather than base salary.

        FACTORS.  Several of the more important factors which we considered in
     establishing the components of each executive officer's compensation
     package for the 1997 fiscal year are summarized below.  Additional factors
     were also taken into account, and we may in our discretion apply entirely
     different factors, particularly different measures of financial
     performance, in setting executive compensation for future fiscal years; all
     compensation decisions will be designed to further the general compensation
     policy indicated above.


                                          21
<PAGE>

     -   BASE SALARY.  The base salary for each officer is set on the basis of
         personal performance and the salary levels in effect for comparable
         positions at similarly situated biopharmaceutical and biomedical 
         companies headquartered in the same geographical region as the Company.
         This group of companies is believed to be more relevant for 
         establishing compensation, and is therefore not the same as the "peer 
         group" of companies referred to in the Performance Graph included in 
         this Proxy Statement which displays comparative total stockholder 
         returns.  As a general rule, we focus on the mid-range of compensation
         for comparable positions at such similarly situated companies in 
         establishing base salary amounts for the Company's executive officers.
         See "Executive Compensation and Other Information -- Employment 
         Contracts and Change of Control Arrangements" regarding the employment 
         agreement in effect between the Company and Dr. Kabakoff.

     -   ANNUAL INCENTIVE COMPENSATION.  Annual bonuses may be earned by each
         executive officer on the basis of the Company's and each officer's
         achievement of corporate and individual performance targets, 
         respectively, which we establish at the beginning of the fiscal year. 
         We do not assign a defined weight to each component of the incentive 
         compensation opportunity.  For fiscal year 1997, the corporate 
         performance targets were primarily focused on growth in earnings per 
         share, with the belief that an increase in the Company's earnings per 
         share is a prime factor in positively affecting the market price of the
         Company's stock.  Accordingly, this element of executive compensation 
         is earned on the basis of the Company's success in achieving the 
         earnings per share growth targets.  There is no fixed percentage of 
         base salary utilized in calculating or setting annual incentive 
         compensation targets.

     -   LONG-TERM INCENTIVE COMPENSATION.  On December 19, 1997, the grants of
         stock options to certain of the Company's executive officers were 
         approved under the Option Plan.  The grants are designed to 
         consistently align the interests of each executive officer with those 
         of the stockholders and to provide each individual with a significant 
         incentive to manage the Company from the perspective of an owner with
         an equity stake in the business.  The number of shares subject to each
         option grant was based on the officer's level of responsibilities, 
         relative position in, and length of service with, the Company.  Each 
         grant allows the officer to acquire shares of Common Stock at a fixed 
         price per share (the market price on the grant date) over a specified 
         period of time (up to 10 years).  Accordingly, the option will provide
         a return to the executive officer only if the market price of the 
         Common Stock appreciates over the option term.

         CEO COMPENSATION.  In setting the compensation payable to the 
     Company's Chief Executive Officer, Mr. Garner, the Compensation Committee 
     has sought to be competitive with other similarly situated companies in 
     the industry as referred to above, while at the same time tying a 
     significant percentage of such compensation to Company performance.

         Mr. Garner's 1997 base salary was established based on our evaluation 
     of his personal performance and the objective of the Compensation Committee
     to have his base salary keep pace with salaries being paid to similarly 
     situated chief executive officers.  Over the last two fiscal years of Mr. 
     Garner's tenure as Chief Executive Officer, the Company has experienced an
     annual compounded growth rate in revenue of 88%.  While this factor has 
     been taken into account in the determination of Mr. Garner's base salary 
     for 1997, it may not be applied to the same extent in future years in 
     setting base salary.  See "Executive Compensation and Other Information --
     Employment Contracts and Change of Control Arrangements" regarding the 
     employment agreement in effect between the Company and Mr. Garner.

         The remaining components of Mr. Garner's 1997 fiscal year compensation
     were entirely dependent upon the Company's financial performance and 
     provided no dollar guarantees.  The cash bonus paid to him for the 1997 
     fiscal year was based on the Company's attainment of the earnings growth 
     targets which we established as his individual bonus plan for the year.  
     The option grant made to him during the 1997 fiscal year was based on his 
     performance during the year and was intended to place a significant portion
     of his total compensation for the year at risk, since the options will have
     no value unless there is appreciation in the value of the Common Stock over
     the option term.  The amount of his 1997 stock option grant, 125,000 shares
     (excluding the 1996 option which was cancelled and regranted in 1997), was 
     determined in light of the Company's record performance in 1997, including 
     growth of 74% in revenues, profit for each of the quarters during the year,
     culminating in growth in earnings per share which represented a 65% 
     increase over the prior year (excluding non-recurring charges principally 
     related to the exercise of the Spiros Development Corporation purchase 
     option and the cash contribution to Spiros


                                          22
<PAGE>

     Development Corporation II, Inc.)  As indicated, it is our objective to 
     have an increasing percentage of Mr. Garner's total compensation each year 
     tied to the attainment of performance targets and stock price appreciation 
     on his option shares.  In establishing bonus amounts, if any, paid to Mr. 
     Garner in future years, we may consider a variety of Company performance 
     factors which will include, but not be limited to, financial performance.

         COMPENSATION COMMITTEE REPORT ON 1997 CANCELLATION AND REGRANT OF 
     OPTIONS.  During the 1997 fiscal year, the Compensation Committee 
     determined that factors affecting the stock price of the Company made it 
     necessary for the Company to implement a program to cancel and regrant 
     certain options to purchase Common Stock held by the Company's executive 
     officers and certain other employees.  A cancellation/regrant program was 
     implemented, whereby certain outstanding options were cancelled and new 
     options for the same number of shares were granted with a lower exercise 
     price per share equal to the fair market price of the Common Stock on the 
     regrant date.

         The Compensation Committee determined that this program was necessary
     because equity incentives are a significant component of the total 
     compensation of each employee and play a substantial role in the Company's
     ability to retain the services of the individuals essential to the 
     Company's long-term financial success.  Prior to implementation of the 
     program, the market price of the Common Stock had fallen and did not 
     necessarily reflect the progress made by the Company in financing 
     operations, product acquisitions, research and development programs and 
     collaborative programs.  The Compensation Committee felt that the Company's
     ability to retain key employees would be significantly impaired unless
     value was restored in the form of regranted options for the Common Stock at
     the then current market price.

         Accordingly, on April 25, 1997, the Compensation Committee approved 
     the cancellation and regrant of all outstanding options granted during the
     period from August 22, 1996 through April 25, 1997 held by current 
     employees.  Each optionee holding such an option had the opportunity to 
     (i) elect to retain the old option or (ii) accept a new option with an 
     exercise price of $25.00 per share, the fair market price of the Common 
     Stock on that date, and to cancel the older, higher-priced option.  Each 
     regranted option covered the same number of shares subject to the 
     higher-priced option at the time of cancellation and vesting on the 
     higher-priced option was forfeited.  The replacement option vests over a 
     new four-year period.

         The Compensation Committee believes the regranted options and new 
     vesting schedule strike an appropriate balance between the interests of the
     option holders and those of the stockholders.  The lower exercise prices in
     effect under the regranted options make those options valuable once again 
     to the executive officers and key employees critical to the Company's 
     financial performance.  However, those individuals will enjoy the benefits 
     of the regranted options only if they remain in the Company's employ and 
     contribute to the Company's and its investors' financial success.

         We conclude our report with the acknowledgment that no member of the
     Compensation Committee is a former or current officer or employee of the 
     Company or any of its subsidiaries.

                                      COMPENSATION COMMITTEE


                                              JAMES C. BLAIR
                                           HERBERT J. CONRAD
                                               DAVID F. HALE


                                          23
<PAGE>

PERFORMANCE GRAPH

     The following graph compares total stockholder returns since the Company
became a reporting company under the Exchange Act, to the Standard & Poor's 500
Index (the "S&P 500") and to a peer group comprised of the Pharmaceutical
Companies in the S&P 500. The graph is constructed on the assumption that $100
was invested on February 7, 1992 in each (a) the Company's Common Stock, (b) the
S&P 500, and (c) the Pharmaceutical Companies in the S&P 500, and that all
dividends were reinvested, although dividends have not been declared on the
Company's Common Stock.  The Pharmaceutical Companies in the S&P 500 consist of
the following pharmaceutical companies:  Eli Lilly and Company, Merck & Co.,
Inc., Pfizer Inc., Schering-Plough Corp. and Upjohn Co.  The stockholder return
shown on the graph below is not necessarily indicative of future performance,
and the Company will not make or endorse any predictions as to future
stockholder returns.

<TABLE>
<CAPTION>

             Dura            S & P 500       S & P Pharmaceutical Companies
  <S>        <C>             <C>             <C>
    2/7/92            100             100             100
   3/31/92    67.34693878     98.19990756     93.34993453
   6/30/92    51.02040816     99.28239558     87.16976053
   9/30/92    57.14285714      101.632246     84.47583852
  12/31/92    59.18367347     105.9889562     84.12953831
   3/31/93    40.81632653     109.8713177     69.91532164
   6/30/93    44.89795918     109.5940062     72.56641500
   9/30/93    46.93877551     111.6373544     65.87046169
  12/31/93    59.18367347     113.4666375     74.43925062
   3/31/94    71.42857143     108.4361089     61.66958309
   6/30/94    85.71428571     108.0712253     68.15506418
   9/30/94     91.2244898     112.5519959     76.83581943
  12/31/94    118.3673469     111.7200613     83.60825247
   3/31/95    121.4285714     121.8005789      93.5451108
   6/30/95    153.5510204     132.5135615     102.8566709
   9/30/95    242.8571429     142.1610839     119.1058602
  12/31/95    283.6734694     149.8285047     137.3055885
   3/31/96    405.1428571     157.0215768     143.2593825
   6/30/96    457.1428571     163.1345934     148.2789002
   9/30/96    569.3877551     167.1920991     152.4883445
  12/31/96    779.5918367      180.189253     175.2670672
   3/31/97    583.6734694     184.1737819     187.2688783
   6/30/97    651.1020408     215.3153811     228.0441992
   9/30/97    712.3265306     230.4312924      232.814087
  12/31/97    749.0612245     236.0626627     264.3800247

</TABLE>


                    CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

TRANSACTIONS WITH MANAGEMENT AND OTHERS

     See "Executive Compensation and Other Information -- Employment Contracts
and Change of Control Arrangements" for a discussion of the employment
agreements between the Company and each Mr. Garner and Dr. Kabakoff.


     Officers and directors of the Company are indemnified pursuant to certain
provisions of the Delaware General Corporation Law and the Company's Certificate
of Incorporation and Bylaws to the fullest extent permitted under Delaware law,
in addition to Indemnification Agreements in effect between the Company and its
officers and directors.

CERTAIN BUSINESS RELATIONSHIPS

     Dr. Kabakoff was President and Chief Executive Officer and a director, and
Mr. Garner also served as a director, of Spiros Corp. during 1997, prior to the
Company's exercise of its purchase option to acquire all of the callable common
stock of Spiros Corp. in December 1997.  Pursuant to certain license,
development and management agreements then in effect, Spiros Corp. engaged the
Company to develop certain compounds to which Spiros Corp. had certain rights,
for delivery through Spiros-Registered Trademark-, the Company's proprietary dry
powder pulmonary drug delivery system.  During 1997, the Company


                                          24
<PAGE>

recorded contract revenues from Spiros Corp. of $19,277,000.  Dr. Kabakoff
currently serves as a director, Chairman, President and Chief Executive Officer,
and Mr. Garner also serves as a director, of Spiros Corp. II, a separate,
newly-formed company which has engaged the Company through various agreements to
further develop certain products to which Spiros Corp. II has rights, for use
with the Spiros-Registered Trademark- system.  The Company has an option to
purchase all of the callable common stock of Spiros Corp. II.  During 1997, the
Company recorded contract revenues from Spiros Corp. II of $6,626,000.


               SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     Section 16(a) of the Exchange Act requires the Company's officers and
directors, and persons who own more than 10% of a registered class of the
Company's equity securities, to file reports of ownership and changes in
ownership with the Securities and Exchange Commission ("SEC") and the Nasdaq
National Market.  Officers, directors and greater than 10% beneficial owners are
required by SEC regulations to furnish the Company with copies of all Section
16(a) forms they file.

     Based solely on review of the copies of such forms furnished to the Company
or written representations from certain reporting persons that no Forms 5 were
required, the Company believes that, during the 1997 fiscal year, its officers,
directors and greater than 10% beneficial owners complied with all applicable
Section 16(a) filing requirements.



                                      FORM 10-K

     THE COMPANY WILL MAIL WITHOUT CHARGE, UPON WRITTEN REQUEST, A COPY OF THE
ANNUAL REPORT ON FORM 10-K, INCLUDING THE FINANCIAL STATEMENTS AND LIST OF
EXHIBITS.  REQUESTS SHOULD BE SENT TO THE ATTENTION OF INVESTOR RELATIONS, DURA
PHARMACEUTICALS, INC., 7475 LUSK BLVD.,  SAN DIEGO, CALIFORNIA 92121.


                                STOCKHOLDER PROPOSALS

     Under the present rules of the SEC, the deadline for stockholders to submit
proposals to be considered for inclusion in the Company's Proxy Statement for
next year's Annual Meeting of Stockholders is expected to be January 21, 1999
(120 days prior to May 21, 1999).  Such proposals may be included in next year's
Proxy Statement if they comply with certain rules and regulations promulgated by
the SEC and the Bylaws of the Company.


                                    OTHER MATTERS

     The Board of Directors is not aware of any matter to be presented for
action at the Annual Meeting other than the matters set forth in this Proxy
Statement.  Should any other matter requiring a vote of the stockholders arise,
the persons named as proxies on the enclosed proxy card will vote the shares
represented thereby in the interests of the Company in accordance with their
best judgment.  Discretionary authority with respect to such other matters is
granted by the execution of the enclosed proxy card.


                              By Order of the Board of Directors


                              /s/ Mitchell R. Woodbury

Dated:  April 16, 1998        MITCHELL R. WOODBURY
                              SENIOR VICE PRESIDENT, GENERAL COUNSEL AND
                              SECRETARY


                                          25
<PAGE>

                                       PROXY

                             DURA PHARMACEUTICALS, INC.

                PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

The undersigned hereby appoints James W. Newman and Mitchell R. Woodbury,
jointly and severally, as proxies, with power to act without the other and with
power of substitution, and hereby authorizes them to represent and vote all of
the shares of Common Stock of Dura Pharmaceuticals, Inc. standing in the name of
the undersigned, as designated on the other side, with all powers which the
undersigned would possess if present at the Annual Meeting of Stockholders to be
held May 21, 1998, or any postponements or adjournments thereof, and to vote in
his or her discretion on such other business as may properly come before the
Meeting and any adjournments thereof.

         (CONTINUED, AND TO BE MARKED, DATED AND SIGNED, ON THE OTHER SIDE)



                           * FOLD AND DETACH HERE *



                                       [LOGO]


<PAGE>

                                                         Please mark     /X/
                                                         your votes as
                                                         indicated in
                                                         this example

THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR ITEMS 1, 2, 3 and 4.

                                                                  WITHHELD
                                                        FOR       FOR ALL  
ITEM 1-ELECTION OF DIRECTORS                                            
       Nominees:                                        / /         / /    
       James C. Blair                                   
       Joseph C. Cook, Jr.                              
       Cam L. Garner                                    
       David F. Hale                                    
       David S. Kabakoff                            
                                                    
                                                    
                                                    

WITHHELD FOR:  (write that nominee's name in the        
space provided below).                                  
                                                        
- ---------------------------------------------           



                                                        FOR   AGAINST   ABSTAIN
ITEM 2 - APPROVAL OF                                    / /     / /       / /  
AMENDMENT TO CERTIFICATE OF INCORPORATION 
                                                
ITEM 3 - APPROVAL OF AMENDMENT                          / /     / /       / /  
TO 1992 STOCK OPTION PLAN

ITEM 4 - RATIFICATION                                   / /     / /       / /  
OF DELOITTE & TOUCHE LLP AS INDEPENDENT  ACCOUNTANTS  

UNLESS OTHERWISE SPECIFIED BY THE UNDERSIGNED, THIS PROXY WILL BE VOTED FOR 
PROPOSALS 1, 2, 3 AND 4 AND WILL BE VOTED BY THE PROXY-HOLDER AT HIS DISCRETION 
AS TO ANY OTHER MATTERS PROPERLY TRANSACTED AT THE MEETING OR ANY 
ADJOURNMENTS THEREOF. TO VOTE IN ACCORDANCE WITH THE BOARD OF DIRECTOR'S 
RECOMMENDATIONS, JUST SIGN BELOW, NO BOXES NEED TO BE CHECKED.                
  

Signature                    Signature                    Date
          ----------------            ---------------         --------------

NOTE:  Please sign as name appears hereon.  Joint owners should each sign. 
When signing as attorney, executor, administrator, trustee or guardian, 
please give full title as such.


                           * FOLD AND DETACH HERE *



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