CORVAS INTERNATIONAL INC
10-Q, 1997-11-12
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                                      FORM 1O-Q
                                           
                          SECURITIES AND EXCHANGE COMMISSION
                                Washington, D.C. 20549
(Mark One)

     [X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES 
         EXCHANGE ACT OF 1934
         For the quarterly period ended September 30, 1997

                                          OR
                                           
     [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
         EXCHANGE ACT OF 1934
         For the transition period from         to        

         Commission file number 0-19732

                              CORVAS INTERNATIONAL, INC.
                (Exact name of Registrant as specified in its charter)
                                           
      DELAWARE                                                33-0238812
(State or other jurisdiction                               (I.R.S. Employer
of incorporation or organization)                           Identification No.)

                                3030 SCIENCE PARK ROAD
                             SAN DIEGO, CALIFORNIA 92121
                (Address of principal executive offices and zip code)
                                           
                                    (619) 455-9800
                 (Registrant's telephone number, including area code)
                                           
Securities registered pursuant to Section 12(b) of the Act: None

Securities registered pursuant to Section 12(g) of the Act:

                            Common Stock, $0.001 par value
                                   (Title of class)
                                           
    Indicate by check mark whether the Registrant (1) has filed all reports 
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 
1934 during the preceding 12 months (or for such shorter period that the 
Registrant was required to file such reports), and (2) has been subject to 
such filing requirements for the past 90 days.

                                    Yes  X    No   
                                       -----     ------

    At October 31, 1997, there were 13,914,256 shares of Common Stock, $0.001
par value, of the Registrant issued and outstanding.



<PAGE>
                              CORVAS INTERNATIONAL, INC.
                                           
                                        INDEX
                                           
                                                                           PAGE
                                                                           ----
                             PART I   FINANCIAL INFORMATION

  Item 1    Financial Statements

            Condensed Balance Sheets as of September 30, 1997 (unaudited)
            and December 31, 1996                                            1

            Unaudited Condensed Statements of Operations for the Three 
            and Nine Months Ended September 30, 1997 and 1996                2

            Unaudited Condensed Statements of Cash Flows for the Nine 
            Months Ended September  30, 1997 and 1996                        3

            Notes to Condensed Financial Statements (unaudited)              4

  Item 2    Management's Discussion and Analysis of Financial
            Condition and Results of Operations                              5

  Item 3    Quantitative and Qualitative Disclosures About Market Risk       8



                                PART II   OTHER INFORMATION
                                           
  Item 1    Legal Proceedings                                                9

  Item 2    Changes in Securities                                            9
              
  Item 3    Defaults Upon Senior Securities                                  9
                   None

  Item 4    Submission of Matters to a Vote of Security Holders              9
                   None

  Item 5    Other Information                                                9
                   None
              
  Item 6    Exhibits and Reports on Form 8-K   
            (a) Exhibits                                                     9

            (b) Reports on Form 8-K                                          9
    

SIGNATURES                                                                  10




<PAGE>

                          PART I -- FINANCIAL INFORMATION

Item 1.  FINANCIAL STATEMENTS

                            CORVAS INTERNATIONAL, INC.
                             CONDENSED BALANCE SHEETS
                                  (In thousands)

<TABLE>
<CAPTION>

                                                       SEPTEMBER 30, 1997  DECEMBER 31, 1996
                                                       ------------------  -----------------
ASSETS                                                     (unaudited)
- ------
<S>                                                    <C>                 <C>
Current assets:
    Cash and cash equivalents                               $   1,431          $   2,202
    Short-term debt securities held to maturity
      and time deposits, partially restricted                  24,355             26,394
    Receivables                                                   449                438
    Notes receivable from related parties                         153                200
    Other current assets                                          567                312
                                                            ---------          ---------
        Total current assets                                   26,955             29,546

Property and equipment, net                                     1,356              1,093
                                                            ---------          ---------
                                                            $  28,311          $  30,639
                                                            ---------          ---------
                                                            ---------          ---------

LIABILITIES AND STOCKHOLDERS' EQUITY
- ------------------------------------

Current liabilities:
    Accounts payable                                           $  354             $  358
    Accrued expenses                                              815                713
    Accrued benefits                                               19                  0
    Accrued vacation                                              189                194
    Current portion of capital lease obligation                     0                 27
    Deferred revenue                                            3,163              4,000
                                                            ---------          ---------
        Total current liabilities                               4,540              5,292
                                                            ---------          ---------

Deferred revenue                                                    0              1,000

Stockholders' equity:
    Preferred stock - Series A                                      1                  1
    Preferred stock - Series B                                      0                  0
    Common stock                                                   14                 14
    Additional paid-in capital                                 92,038             91,629
    Accumulated deficit                                       (68,282)           (67,297)
                                                            ---------          ---------
        Total stockholders' equity                             23,771             24,347

Commitments and contingencies
                                                            ---------          ---------
                                                            $  28,311          $  30,639
                                                            ---------          ---------
                                                            ---------          ---------
</TABLE>

See accompanying notes to condensed financial statements.

                                       1
<PAGE>


                           CORVAS INTERNATIONAL, INC.

                       CONDENSED STATEMENTS OF OPERATIONS
               In thousands, except per share amounts (unaudited)

<TABLE>
<CAPTION>
                                                 Three Months Ended            Nine Months Ended
                                                    September 30,                 September 30,
                                              -----------------------       -----------------------
                                                1997           1996           1997           1996 
                                              --------       --------       --------       --------
<S>                                           <C>            <C>            <C>            <C>
REVENUES: 
  Revenue from collaborative agreements       $  1,746       $  1,085       $  4,065       $  4,255
  License fees & milestones                          0              0          4,100              0
  Net product sales                                 76            101            240            147
  Royalties                                         32             18             88             99
                                              --------       --------       --------       --------
    Total revenues                               1,854          1,204          8,493          4,501
                                              --------       --------       --------       --------

COSTS AND EXPENSES:
  Research and development                       2,230          2,449          7,272          8,365
  General and administrative                       991            625          3,230          2,312
  Cost of products sold                             53             75            130            129
                                              --------       --------       --------       --------
    Total costs and expenses                     3,274          3,149         10,632         10,806
                                              --------       --------       --------       --------

    Loss from operations                        (1,420)        (1,945)        (2,139)        (6,305)

OTHER INCOME:
  Interest income, net                             440            332          1,154            901
  Other income                                       0              1              0             31
                                              --------       --------       --------       --------
                                                   440            333          1,154            932
                                              --------       --------       --------       --------

    Net loss                                  $   (980)      $ (1,612)      $   (985)      $ (5,373)
                                              --------       --------       --------       --------
                                              --------       --------       --------       --------

    Net loss per share                        $  (0.07)      $  (0.12)      $  (0.07)      $  (0.42)
                                              --------       --------       --------       --------
                                              --------       --------       --------       --------

    Shares used in calculation
     of net loss per share                      13,898         13,705         13,854         12,650
                                              --------       --------       --------       --------
                                              --------       --------       --------       --------
</TABLE>

See accompanying notes to condensed financial statements.

                                       2
<PAGE>

                             CORVAS INTERNATIONAL, INC.

                        CONDENSED STATEMENTS OF CASH FLOWS
                              IN THOUSANDS (UNAUDITED)

<TABLE>
<CAPTION>
                                                                     Nine Months Ended
                                                                       September 30,
                                                                 ------------------------
                                                                    1997           1996
                                                                 ---------      ---------
<S>                                                              <C>            <C>
Cash flows from operating activities:
  Net loss                                                       $    (985)     $  (5,373)
  Adjustments to reconcile net loss to
   net cash used in operating activities:
    Depreciation and amortization                                      472            613
    Amortization of premiums and discounts on investments              (71)           184
    Stock compensation expense                                           6              1
    Change in assets and liabilities:
      (Increase) decrease in receivables                               (11)            58
      Increase in other current assets                                (255)          (187)
      Increase (decrease) in accounts payable, accrued
       expenses, accrued benefits, accrued vacation
       and accrued litigation settlement expenses                      112           (374)
      Decrease in deferred rent                                          0         (3,285)
      Decrease in deferred revenue                                  (1,837)           (34)
                                                                 ---------      ---------
        Net cash used in operating activities                       (2,569)        (8,397)
                                                                 ---------      ---------


Cash flows from investing activities:
  Purchases of investments held to maturity                        (30,214)       (26,752)
  Proceeds from maturity of investments held to maturity            32,538         15,640
  Purchases of property and equipment                                 (955)          (349)
  Repayments from (loans to) related parties                            47           (380)
                                                                 ---------      ---------
        Net cash provided by investing activities                    1,416        (11,841)
                                                                 ---------      ---------

Cash flows from financing activities:
  Principal payments under capital lease obligation                    (27)           (57)
  Net proceeds from issuance of common stock                           409         19,967
                                                                 ---------      ---------
        Net cash provided by financing activities                      382         19,910
                                                                 ---------      ---------

Net decrease in cash and cash equivalents                             (771)          (328)

Cash and cash equivalents at beginning of period                     2,202          1,427
                                                                 ---------      ---------

Cash and cash equivalents at end of period                       $   1,431      $   1,099
                                                                 ---------      ---------
                                                                 ---------      ---------

Supplemental disclosures:
  Interest paid                                                  $       0      $       5
                                                                 ---------      ---------
                                                                 ---------      ---------
  Noncash financing activities - 
    Common stock issued under litigation settlement agreement    $       0      $     298
                                                                 ---------      ---------
                                                                 ---------      ---------
</TABLE>

See accompanying notes to condensed financial statements.

                                       3
<PAGE>
                              CORVAS INTERNATIONAL, INC.

                       NOTES TO CONDENSED FINANCIAL STATEMENTS
                                     (UNAUDITED)

(1)  THE COMPANY

    Corvas International, Inc. (the "Company") was incorporated on March 27, 
1987 under the laws of the State of California.  In July 1993, the Company 
reincorporated in the State of Delaware.  The Company is engaged in the 
design and development of a new generation of therapeutic agents for the 
prevention and treatment of major cardiovascular, inflammatory and other 
diseases.

(2)  BASIS OF PRESENTATION

    The interim financial information contained herein is unaudited but, in 
management's opinion, includes all adjustments, consisting only of normal 
recurring adjustments, necessary for a fair presentation.  The financial 
statements should be read in conjunction with the Company's audited financial 
statements and notes thereto for the year ended December 31, 1996.

    Results for the interim periods are not necessarily indicative of results 
for other interim periods or for the full year.

(3)  NET LOSS PER SHARE

    Net loss per share for the three and nine months ended September 30, 1997 
and 1996 is computed using the weighted average number of common share 
equivalents outstanding.  Common equivalent shares are not included in the 
per share calculation since the effect of their inclusion would be 
anti-dilutive.

                                       4
<PAGE>

Item 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
         CONDITION AND RESULTS OF OPERATIONS

    EXCEPT FOR THE HISTORICAL INFORMATION CONTAINED HEREIN, THE FOLLOWING 
DISCUSSION CONTAINS FORWARD-LOOKING STATEMENTS THAT INVOLVE RISKS AND 
UNCERTAINTIES.  THE COMPANY'S ACTUAL RESULTS COULD DIFFER MATERIALLY FROM 
THOSE PROJECTED IN THE FORWARD-LOOKING STATEMENTS. FACTORS THAT COULD CAUSE 
OR CONTRIBUTE TO SUCH DIFFERENCES INCLUDE, BUT ARE NOT LIMITED TO, THOSE 
DISCUSSED IN THIS SECTION AND THOSE DISCUSSED IN THE COMPANY'S ANNUAL REPORT 
ON FORM 10-K.

OVERVIEW

    Formed in 1987, Corvas International, Inc. ("Corvas" or the "Company") is 
a biopharmaceutical firm engaged in the design and development of a new 
generation of therapeutic agents for the prevention and treatment of major 
cardiovascular, inflammatory and other diseases.  To date, the Company has 
not generated significant revenues from product sales.  The Company has not 
been profitable on an annual basis since inception and expects to incur 
substantial additional operating losses on an annual basis over the next 
several years as the Company attempts to sustain, and possibly expand, its 
research and development and clinical trial efforts.  No assurance can be 
given that the Company will generate sufficient revenues to become profitable 
on a sustained basis or at all.  At September 30, 1997, the Company had an 
accumulated deficit of $68,282,000.

RESULTS OF OPERATIONS

THREE MONTHS ENDED SEPTEMBER 30, 1997 AND 1996

    Comparing the third quarters of 1996 and 1997, operating revenues 
increased from $1,204,000 in 1996 to $1,854,000 in 1997.  Of this $650,000 
increase, $394,000 is attributable to a license and collaboration agreement 
initiated in June 1997 with Schering Corporation ("Schering-Plough") which 
covers the design and development of orally-bioavailable inhibitors of a key 
protease necessary for hepatitis C virus replication.  An additional $240,000 
relates to an option agreement to purchase all of the outstanding stock of 
Vascular Genomics Inc. ("VGI"), a private company with a proprietary position 
in a novel vascular targeting technology, which was also initiated in June 
1997.

    Total costs and expenses increased from $3,149,000 in the three month 
period ended September 30, 1996 to $3,274,000 in the same period of 1997.  A 
$219,000 decrease in research and development expenditures, primarily due to 
costs incurred in the third quarter of 1996 for the manufacture of clinical 
supplies for rNAPc2, was offset by a $366,000 increase in general and 
administrative expenses.  The primary factors contributing to this increase 
were administrative recruiting and relocation costs, and legal and other 
costs in connection with various business development activities.

    Total other income increased $107,000 comparing the quarter ended 
September 30, 1996 to the corresponding quarter of 1997.  This is the result 
of higher rates of return earned on cash and investment balances.

NINE MONTHS ENDED SEPTEMBER 30, 1997 AND 1996 

    Operating revenues increased from $4,501,000 in the nine month period 
ended September 30, 1996 to $8,493,000 in the same period of 1997.  This 
$3,992,000 increase is principally due to a $3,000,000 milestone payment 
received from Schering-Plough in the first quarter of 1997 pursuant to the 
companies' strategic alliance agreement to develop oral thrombin inhibitors.  
Also in the first quarter of 1997, Corvas recognized a license fee of 
$850,000 pursuant to its collaboration with Pfizer Inc. ("Pfizer") covering 
the development of neutrophil inhibitory factor ("NIF"), an anti-inflammatory 
agent.

                                      5
<PAGE>

    Comparing the nine month periods ended September 30, 1996 and 1997, total 
costs and expenses decreased from $10,806,000 to $10,632,000.  Such decrease, 
primarily due to costs incurred in 1996 for the manufacture of clinical 
supplies, caused research and development expenditures to decrease by 
$1,093,000, while general and administrative expenses increased by $918,000 
for the reasons cited earlier.

    Increased interest income caused total other income to increase from 
$932,000 in the first nine months of 1996 to $1,154,000 in the corresponding 
period of 1997.

    Subject to the availability of additional capital, the Company expects 
its expenses to increase over the next several years as the Company's 
research and development programs progress.  The Company also expects both 
its expenses and losses to fluctuate from quarter to quarter and that such 
fluctuations may, at times, be substantial.

LIQUIDITY AND CAPITAL RESOURCES

    Since inception, the Company's operations have been funded primarily 
through public offerings and private placements of equity securities, 
revenues from collaborative agreements, license fees, milestone payments and 
research grants, and interest income earned on cash and investment balances.  
The Company's principal sources of liquidity are its cash and cash 
equivalents, time deposits and debt securities which, net of a restricted 
time deposit, totaled $25,726,000 as of September 30, 1997.  Working capital 
at September 30, 1997 was $22,415,000.  Available cash is invested in 
accordance with an investment policy set by the Board of Directors, which has 
the objectives to preserve principal, maintain adequate liquidity and 
maximize income.  The policy provides guidelines concerning the quality, term 
and liquidity of investments.  The Company presently invests its excess cash 
in U.S. government securities.

    Strategic collaborations with Schering-Plough and Pfizer provide for 
payments to the Company if and when certain milestones are met. However, 
there can be no assurance that any future milestones will be achieved.  
During the first quarter of 1997, a development compound was selected by 
Schering-Plough in the thrombin inhibitor program, which triggered a 
$3,000,000 milestone payment; the next milestone in this program, if 
achieved, is $1,000,000 to be paid upon filing by Schering-Plough of an 
Investigational New Drug Application ("IND") or its equivalent for initiating 
clinical trials in the U.S. or any corresponding foreign application, 
registration or certification.  The next milestone in the Corvas/Pfizer 
collaboration, if achieved, is $1,000,000 to be paid upon notification to a 
regulatory authority, such as the U.S. Food and Drug Administration, of a 
plan for clinical trials for NIF.  In addition to these and certain other 
contractually-defined payments, the Company may also receive capital 
resources from additional milestone payments and royalties on sales of 
products in connection with its existing alliances, as well as from potential 
future alliances.  If all of the milestones on all of the Company's existing 
collaborations are met, Corvas could receive up to a total of $96,025,000 in 
milestone payments over the next several years. However, there can be no 
assurance that the Company will successfully develop and commercialize any 
products or that the Company will receive any additional amounts under these 
or future alliances.

                                      6
<PAGE>

         In June 1997, Corvas entered into an option agreement to purchase 
all of the outstanding stock of VGI, a vascular targeting company.  If this 
option is exercised, the purchase will be made with newly-issued Corvas 
common stock.  The aggregate purchase price, which is based on the timing of 
the option exercise,  presently ranges between $13,554,000 and $19,960,000.  
If Corvas elects not to exercise its option, VGI may require Corvas to 
purchase 19.9% of its outstanding stock for $3,960,000 in Corvas common 
stock.  During the option period, Corvas will make option payments to VGI, 
which in turn will fund certain research and development activities at 
Corvas.  Although the net impact of these payments is not material, the 
Company may incur substantial additional costs to develop this technology.  
Corvas may enter into one or more collaborative relationships to develop and 
commercialize this technology.  However, there can be no assurance that the 
Company will be able to establish such relationships on satisfactory terms, 
that such relationships will successfully reduce the costs associated with 
research and development of this technology, that the option will be 
exercised, or that this technology will prove to be effective.

    The Company expects to incur substantial additional costs in the 
foreseeable future, including costs related to sustaining, and possibly 
expanding, research and development activities and preclinical and clinical 
testing.  The Company expects such costs to continue to increase and,  as a 
result, expects to experience substantial additional operating losses over 
the next several years. The Company presently expects to file an IND in the 
first half of 1998 for rNAPc2, an anticoagulant for which a Phase Ib clinical 
trial has recently begun.  The Company believes its capital resources, 
interest earned thereon and the funds committed by Schering-Plough under the 
companies' strategic alliance agreement covering inhibitors of Factor Xa will 
satisfy its funding requirements through the middle of 1999.

    Corvas' future funding requirements will depend on many factors, 
including, but not limited to, the following: continued scientific progress 
in its drug discovery programs; the magnitude of these programs; progress of 
preclinical testing and clinical trials; the time and costs involved in 
obtaining regulatory approvals; the costs involved in filing, prosecuting, 
maintaining and enforcing patent claims; competing technological and market 
developments; changes in its existing research relationships; the ability of 
the Company to establish and to maintain collaborative or licensing 
arrangements; the cost of manufacturing scale-up; and effectiveness of 
activities and arrangements to commercialize existing and potential products. 
Corvas leases its laboratory and office facilities under an operating lease 
and anticipates that it will need to expand its facilities over the next 
several years.  The Company expects it will acquire additional property and 
equipment as its research and development activities progress.

    The Company's business is subject to significant risks including, but not 
limited to, the risks associated with its research and development efforts, 
obtaining and enforcing patents, the lengthy and expensive regulatory 
approval process, product reimbursement levels, competition from other 
products, dependence on collaborative partners and other third parties, the 
possibility of early termination of corporate collaborations, and the 
availability of capital.  Even if the Company's products appear promising at 
an early stage of development, they may not reach the market for a number of 
reasons, including the possibility that such potential products will be 
ineffective or found to be unsafe during clinical trials, will not receive 
necessary regulatory approvals, will be difficult to manufacture on a large 
scale, will be uneconomical to market or will be precluded from 
commercialization by proprietary rights of third parties.

    Uncertainties associated with the duration and expense of preclinical and 
clinical testing of any of the Company's existing or potential products make 
it difficult to predict the Company's funding requirements, and unexpected 
developments and/or regulatory requirements could greatly increase the cost 
of development of such products and affect the timing of anticipated product 
revenues. Failure by the Company to obtain regulatory approval for any 
product will preclude the sale of such product.  In addition, failure by the 
Company to obtain patent protection may make certain of its products 
commercially unattractive.

                                      7
<PAGE>

    To continue its product development efforts, the Company must raise 
substantial additional funds through public or private sales of securities, 
collaborative arrangements or other methods of financing. The Company's 
ability to raise additional funds through sales of securities depends in part 
on investors' perceptions of the biotechnology industry, in general, and of 
the Company, in particular. The market for biotechnology company stocks has 
historically been highly volatile and, accordingly, there can be no assurance 
that additional funding will be available, or, if available, that it will be 
available on acceptable terms.  The Company may enter into additional 
collaborative relationships to develop and commercialize certain of its 
technologies or products.  There can be no assurance that the Company will be 
able to establish such relationships on satisfactory terms, if at all, or 
that agreements with collaborators will successfully reduce the Company's 
funding requirements.  In addition, the Company has no established bank 
financing arrangements, and there can be no assurance that it will be able to 
establish such arrangements on satisfactory terms, if at all.  If adequate 
funds are not available, the Company may be required to significantly delay, 
scale back or eliminate one or more of its drug discovery programs or obtain 
funds through arrangements with collaborative partners or others that may 
require the Company to relinquish rights to certain of its technologies, 
product candidates or products that the Company would not otherwise 
relinquish.

    In 1993, the U.S. Patent and Trademark Office (the "USPTO") declared an 
interference to determine the priority of invention between a patent for 
which some rights are licensed to the Company (the "Licensed Patent") and a 
patent application for which rights are held by other parties (the "First 
Patent Application").  In 1996, the USPTO added a second patent application 
to the proceeding (the "Second Patent Application") and redeclared the 
interference.  Rights to the Second Patent Application are held by other 
parties, at least some of which also hold rights in the First Patent 
Application.  The subject matter of the patent and these applications is 
recombinant tissue factor, which is used by Ortho Diagnostic Systems, Inc. 
("Ortho"), a Johnson & Johnson company,  to determine the blood clotting 
abilities of patients.  The Company is contesting the other parties' claims 
of prior invention; however, there can be no assurance that the Licensed 
Patent will be upheld.

Item 3.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

    Not applicable

                                     8
<PAGE>
                             PART II -- OTHER INFORMATION


Item 1.  LEGAL PROCEEDINGS   

    In 1993, the U.S. Patent and Trademark Office (the "USPTO") declared an 
interference to determine the priority of invention between a patent for 
which some rights are licensed to the Company (the "Licensed Patent") and a 
patent application for which rights are held by other parties (the "First 
Patent Application").  In 1996, the USPTO added a second patent application 
to the proceeding (the "Second Patent Application") and redeclared the 
interference. Rights to the Second Patent Application are held by other 
parties, at least some of which also hold rights in the First Patent 
Application.  The subject matter of the patent and these applications is 
recombinant tissue factor, which is used by Ortho Diagnostic Systems, Inc. 
("Ortho"), a Johnson & Johnson company,  to determine the blood clotting 
abilities of patients.  The Company is contesting the other parties' claims 
of prior invention; however, there can be no assurance that the Licensed 
Patent will be upheld.    

Item 2.  CHANGES IN SECURITIES

    On September 18, 1997, the Company adopted a Stockholder Rights Plan 
which is described in the Current Report on Form 8-K filed on October 8, 1997.

Item 3.  DEFAULTS UPON SENIOR SECURITIES

    None

Item 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

    None

Item 5.  OTHER INFORMATION

    None

Item 6.  EXHIBITS AND REPORTS ON FORM 8-K

    a. Exhibits

    EXHIBIT NUMBER   DESCRIPTION
    --------------   -----------
        10.62        Amended and Restated Secured Promissory Note between 
                     the Company and  Randall E. Woods, dated as of 
                     August 28, 1997.

        10.63        Separation Agreement between the Company and William C. 
                     Ripka, dated as of September 23, 1997.

        27.1         Financial Data Schedule.

    b. Reports on Form 8-K

    On October 8, 1997, the Company filed a Current Report on Form 8-K which 
discloses certain information under Item 5.

                                         9
<PAGE>

                                      SIGNATURES



     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this Report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                       CORVAS INTERNATIONAL, INC.



Date: November 12, 1997                By: /s/ RANDALL E. WOODS
                                           --------------------------------
                                           Randall E. Woods
                                           President and Chief 
                                            Executive Officer




Date: November 12, 1997                By: /s/ JOHN E. CRAWFORD
                                           --------------------------------
                                           John E. Crawford
                                           Executive Vice President
                                            and Chief Financial Officer



                                       10

<PAGE>

                 AMENDED AND RESTATED SECURED PROMISSORY NOTE


$152,500                                                     August 28, 1997


    A.   Randall E. Woods, an individual residing in the State of California 
("Borrower"), has executed that certain Promissory Note dated June 25, 1996 
(the "Original  Note") in an original principal amount of $200,000 in favor 
of Corvas International, Inc., a Delaware corporation ("Lender"), evidencing 
a loan made by Lender to Borrower in connection with the relocation of 
Borrower to San Diego, California. Payment and performance in respect of the 
Original Note was to be secured by that certain unrecorded Deed of Trust 
dated June 25, 1996 (the "Deed of Trust") to encumber certain real property 
located in Potomac, Maryland (the "Property") formerly owned by Borrower.

    B.   On January 30, 1997, Lender executed that certain Extension of 
Promissory Note pursuant to which the final maturity date of the Original 
Note was extended from December 7, 1996 to the earlier of the sale of the 
Property or December 7, 1997.

    C.   On May 1, 1997, Lender agreed to pay to Borrower the difference 
between the purchase price originally paid by Borrower for the Property and 
the sales price when the Property actually sold, not to exceed $47,500.  On 
August 28, 1997, Borrower sold the Property and applied the $47,500 against 
the outstanding principal amount owing under the Original Note.  The current 
principal balance outstanding under the Original Note is $152,500.

    D.   Borrower has filed various claims against various defendants in the 
Superior Court of the State of California for the County of San Diego, North 
County Judicial District, (Case No. N075230) in connection with certain 
alleged defects and other matters related to certain real property owned by 
Borrower in the County of San Diego, State of California (the "Lawsuit").

    E.   As  approved by resolution of the Board of Directors of Lender at 
its Board meeting held September 18, 1997, Borrower and Lender each desires 
to amend and restate in its entirety the Original Note pursuant to this 
Amended and Restated Secured Promissory Note (the "Note") to (a) extend the 
final maturity date to the earliest of (i) September 18, 1998, (ii) the 
settlement or other final determination of the Lawsuit and (iii) the date 
which is ninety days after any termination of employment of Borrower with 
Lender for any reason or no reason (with or without cause) and (b) to provide 
for the grant of a security interest in all of Borrower's right, title and 
interest in the Lawsuit and the proceeds thereof to secure the repayment of 
principal under this Note and the payment of all costs incurred by Lender 
pursuant to the enforcement of Lender's rights under this Note and the 
performance of all other obligations under this Note by Borrower.

For Value Received, Borrower, under the terms of this Note, hereby 
unconditionally promises to pay to Lender in lawful money of the United 
States of America and in immediately available funds, the principal sum of 
One Hundred Fifty-Two Thousand Five Hundred and 00/100 Dollars ($152,500) 
(the "Loan"), payable on the dates, in the amounts and in the manner set 
forth below.

    1.   REPAYMENT; PREPAYMENT.  The outstanding principal amount of the Loan 
shall be due and payable on the earliest of (i) September 18, 1998 (ii) the 
settlement or other final determination of the Lawsuit and (iii) the date 
which is ninety days after any

<PAGE>

termination of employment of Borrower with Lender for any reason or no reason 
(with or  without cause).  The Loan may be prepaid at any time without 
penalty. Amounts so prepaid shall not be re-borrowed.

    2.   APPLICATION OF PAYMENTS/PLACE OF PAYMENT.  All payments received by 
Lender shall be applied first to any charges due with respect to this Note or 
any other document executed by Borrower in connection herewith and second to 
the unpaid principal balance.  All amounts payable hereunder  shall be 
payable at the office of Lender, 3030 Science Park Road, San Diego, 
California 92121, unless another place of payment shall be specified in 
writing by Lender to Borrower.  Any  amounts payable hereunder  will be due 
and payable without set-off, deduction, or counterclaim, except as otherwise 
provided herein.

    3.   SECURED NOTE.  In order to secure the prompt and complete payment 
and performance of all obligations of Borrower under this Note, including, 
without limitation, the repayment of principal and the reimbursement of all 
costs of enforcing any of Lender's rights under this Note (including, without 
limitation, reasonable attorneys' fees, disbursements, costs and other 
expenses), Borrower hereby grants to Lender a security interest in all of 
Borrower's right, title and interest in the lawsuit filed by Borrower and 
Nancy Saint Woods, an individual, in the Superior Court of the State of 
California for the County of San Diego, North County Judicial District, known 
as Case No. N075230 and the proceeds thereof (the "Collateral").  Borrower 
hereby agrees to execute a UCC-1 Financing Statement in the form attached 
hereto as Exhibit "A", and from time to time to execute any and all other 
documents reasonably requested by Lender to perfect Lender's security 
interest in the Collateral.  Upon the repayment in full of all obligations 
under this Note, Lender hereby agrees to execute all documents and exercise 
such further actions as necessary to release the security interest in the 
Collateral  and to terminate any and all UCC financing statements or similar 
filings then effective with respect to the Collateral.  If an Event of 
Default has occurred and is continuing, Lender shall have all of the rights 
and remedies with respect to the Collateral of a secured creditor under the 
Uniform Commercial Code as  in effect in the State of California.

    4.   DEFAULT.  An Event of Default under this Note shall  have occurred 
upon the occurrence  of any one or more the following events: (1) the 
Borrower's failure to pay any of the principal due under this Note when the 
same becomes due and payable or the Borrower's failure to pay any other 
amounts payable under this Note on the date the same become due and payable 
or within five (5) calendar days thereafter, (2) the filing by Borrower of a 
petition under the United States Bankruptcy Code or (3) the death of Borrower 
or any other maker, endorser, guarantor of this Note.  Upon the occurrence of 
an Event of Default, all unpaid principal and any other amounts owing 
hereunder shall, at the option of Lender, be immediately  collectible  by 
Lender pursuant  to applicable law, and Lender may exercise any and all 
remedies of a secured creditor under the UCC.

    5.   WAIVER.  Borrower, and any endorsers or guarantors hereof, each 
severally waives diligence, presentment, protest and demand  and also notice 
of protest, demand, dishonor, acceleration, intent to accelerate and 
nonpayment of this Note, and expressly agrees that this Note, or any payment 
hereunder, may be extended from time to time without notice, and consent to 
the acceptance of further security or the release of any security for this 
Note, all without in any way affecting the liability of Borrower or any 
endorsers or guarantors hereof.  No extension of time for the payment  of 
this Note, or any installment hereof, agreed to by Lender with any person now 
or hereafter liable for the payment of this Note, shall affect the original 
liability of Borrower under this Note, even if Borrower is not party to such 
an agreement or indulgence. Borrower shall pay all costs of

<PAGE>

collection when incurred, including, without limitation, reasonable 
attorneys' fees, disbursements, costs and other expenses.

         The right to plead any and all statutes of limitations as a defense 
to any demands  hereunder is hereby  waived to the full extent permitted by 
law.

    6.   GOVERNING LAW.  This Note shall be governed by, and construed and 
enforced in accordance with, the laws of the State of California, excluding 
conflict of laws principles that would cause the application of laws of any 
other jurisdiction.

    7.   SUCCESSORS.  The  provisions of this Note shall inure to the benefit 
of and be binding on any successor or assign to Borrower or Lender.  This 
Note shall not be assigned by Borrower without the prior written consent of 
Lender.

    8.   MISCELLANEOUS.

         a.   Borrower shall pay all costs, including, without limitation, 
reasonable  attorneys' fees incurred by  Lender in collecting the  sums due 
hereunder or  in connection  with the release of the security for this Note.

         b.   This Note may be modified only by a written agreement executed 
by Borrower and Lender.

         c.   Time is of the essence with respect to all matters set forth in 
this Note.

         d.   If this Note is destroyed, lost or stolen, Borrower shall 
deliver a new note to Lender on the same terms and conditions as this Note 
with a notation of the unpaid principal in substitution of the prior Note.  
Lender shall furnish to Borrower reasonable evidence that the Note was 
destroyed, lost or stolen and any security or indemnity that may be 
reasonably required by Borrower in connection with the replacement of this 
Note.

         e.   If any provision of this Note shall be held to be invalid and 
unenforceable, such determination shall not affect the remaining provisions 
of this Note.

         f.   In the event an action is commenced  to interpret or enforce 
this Note or to collect any sums due hereunder, the prevailing party shall be 
entitled to receive from the other party attorneys' fees, disbursements,  
costs and other expenses determined by the court in which such action is 
brought.

         g.   This Amended and Restated Secured Promissory Note is not 
intended to be, and shall not be construed to create, a novation or accord 
and satisfaction, and, except as otherwise provided herein, the terms of the 
Original  Note, as extended prior to the execution hereof, shall remain in 
full force and effect.

                                       /s/ RANDALL E. WOODS
                                       ----------------------------
                                       Randall E. Woods, Borrower


<PAGE>


[Corvas letterhead]



September 23, 1997

William C. Ripka, Ph.D.
10819 Red Rock Drive
San Diego, California  92131

Dear Bill:

This letter sets forth the terms and conditions of our agreement (the 
"Agreement") regarding your retirement from Corvas International, Inc. (the 
"Company").  This Agreement shall supersede any and all previous agreements 
between you and the Company including, but not limited to, that Employment 
Agreement (the "Employment Agreement") dated March 18, 1997, provided, 
however, that the confidentiality agreement attached as Exhibit C to the 
Employment Agreement shall continue in full force and effect.

This Agreement is made and entered into as of the last day either party 
executes this Agreement.  Pursuant to paragraph 13 set forth below, the 
Agreement shall become effective on the eighth day after this Agreement is 
signed by you (the "Effective Date").  You and the Company hereby agree as 
follows:

1.       This Agreement confirms your retirement from the Company and 
resignation of your position as Senior Vice President, Chemical Research, of 
the Company as of September 30, 1997 (the "Separation Date").  

2.       The Company agrees that it will pay you all accrued salary, and all 
accrued and unused vacation benefits earned through the Separation Date, if 
any, subject to standard payroll deductions, withholding taxes and other 
obligations. You are entitled to this payment regardless of whether or not 
you sign this Agreement.

3.       Although the Company has no policy or procedure for providing 
severance benefits, in exchange for the promises and covenants set forth 
herein, and in consideration thereof, the Company will pay you the equivalent 
of twelve months of your base salary in effect as of the Separation Date, 
subject to standard payroll deductions and withholdings.  Half of this amount 
will be paid in a lump sum within fourteen (14) days of the Effective Date of 
this Agreement as defined in paragraph 13, with the rest paid out over the 
next six (6) months.

4.       To the extent provided by the federal COBRA law or, if applicable, 
state insurance laws, and by the Company's current group health insurance 
policies, you will be eligible to continue your health insurance benefits.  
You will be provided with a separate notice of your COBRA rights.  In the 
event that you elect continued coverage under COBRA, the Company, as part of 
this Agreement and in consideration thereof, will reimburse you on a monthly 
basis for the same portion of your COBRA health insurance premium that it 
paid during your employment for one year from the Separation Date.  You will 
continue to be responsible for the same portion of the COBRA health insurance 
premium that you paid during your employment with the Company.

5.       In exchange for the promises and covenants set forth herein, the 
Company agrees that the vesting of each outstanding stock option held by you 
as set forth on Exhibit A attached hereto (the "Stock Options") shall be 
fully accelerated and become immediately exerciseable in full; provided,

<PAGE>

William C. Ripka, Ph.D.
September 23, 1997
Page 2

that in any event, should you choose to exercise your Stock Options, you must 
do so within twenty-four (24) months of the Separation Date as provided in 
Section 3.3(c) of the standard terms and conditions relating to Incentive 
Stock Options attached to and made part of your Incentive Stock Option 
Agreement dated December 4, 1996 (your "Stock Option Agreement").  Your Stock 
Options will terminate twenty-four (24) months after the Separation Date if 
not exercised.  You agree that you otherwise remain bound by the terms and 
conditions of your Stock Option Agreement.  In addition, you understand that, 
pursuant to tax law, your Stock Options will lose potentially favorable tax 
treatment afforded "incentive stock options" if not exercised within three 
(3) months of the Separation Date.

6.       You hereby acknowledge and agree that except as expressly provided 
herein, you will not receive (nor are you entitled to) any additional 
compensation, severance, benefits, shares of Company stock or stock options 
exerciseable for Company stock, notwithstanding any prior agreement to the 
contrary, including the Employment Agreement, after the Separation Date.

7.       You agree that, within ten (10) days of the Separation Date, you 
will submit your final documented expense reimbursement statement reflecting 
all business expenses you incurred through the Separation Date, if any, for 
which you seek reimbursement.  The Company will reimburse you for these 
expenses pursuant to its regular business practice.  You further agree that 
you will not be entitled to any expense reimbursements after the Separation 
Date.

8.       You agree that for one year after the Separation Date, you will not, 
either directly or through others, solicit or attempt to solicit any 
employee, consultant, or independent contractor of the Company to terminate 
his or her relationship with the Company in order to become an employee, 
consultant or independent contractor to or for any other person or entity.

9.       Upon the Separation Date, you agree to return to the Company all 
Company documents (and all copies thereof) and other Company property in your 
possession or your control, including, but not limited to, Company files, 
notes, samples of compounds, drawings, specifications, calculations, 
sequences, data, computer-recorded information, tangible property, including, 
but not limited to, computers, credit cards, entry cards, keys and any other 
materials of any nature pertaining to your work with the Company, and any 
documents or data of any description (or any reproduction of any documents or 
data) containing or pertaining to any proprietary or confidential material of 
the Company.

10.      Both during and after your employment you acknowledge your 
continuing obligations under your Employment Agreement not to use or disclose 
any confidential or proprietary information of the Company without prior 
written authorization from a duly authorized representative of the Company.  
A copy of your Employment Agreement is attached hereto as Exhibit B.

11.      You and the Company agree that neither party will at any time 
disparage the other party, and the other party's officers, directors, 
employees, shareholders and agents, in any manner likely to be harmful to 
them or their business, business reputation or personal reputation; provided 
that each party shall respond accurately and fully to any questions, inquiry 
or request for information when required by legal process.

<PAGE>

William C. Ripka, Ph.D.
September 23, 1997
Page 3

12.      The provisions of this Agreement shall be held in strictest 
confidence by you and the Company and shall not be publicized or disclosed in 
any manner whatsoever;  provided, however, that: (a) you may disclose this 
Agreement, in confidence, to your immediate family; (b) the parties may 
disclose this Agreement in confidence to their respective attorneys, 
accountants, auditors, tax preparers, and financial advisors; (c) the Company 
may disclose this Agreement as necessary to fulfill standard or legally 
required corporate reporting or disclosure requirements; and (d) the parties 
may disclose this Agreement insofar as such disclosure may be necessary to 
enforce its terms or as otherwise required by law.

13.      In exchange for the promises and covenants set forth herein, you 
hereby release, acquit, and forever discharge the Company, its parents and 
subsidiaries, and their officers, directors, agents, servants, employees, 
attorneys, shareholders, partners, successors, assigns, affiliates, 
customers, and clients of and from any and all claims liabilities, demands, 
causes of action, costs, expenses, attorneys' fees, damages, indemnities and 
obligations of every kind and nature, in law, equity, or otherwise, known and 
unknown, suspected and unsuspected, disclosed and undisclosed, arising out of 
or in any way related to agreements, acts or conduct at any time prior to the 
Separation Date, including, but not limited to: all such claims and demands 
directly or indirectly arising  out of or in any way connected with the 
Company's employment of you, the termination of that employment, and the 
Company's performance of its obligations as your former employer; claims or 
demands related to salary, bonuses, commissions, stock, stock options, or any 
other ownership interests in the Company, vacation pay, fringe benefits, 
expense reimbursements, severance pay, or any form of compensation; claims 
pursuant to any federal, state or local law or cause of action including, but 
not limited to, the California Fair Employment and Housing Act, the federal 
Civil Rights Act of 1964, as amended; the federal Age Discrimination in 
Employment Act of 1967, as amended; the federal Americans With Disabilities 
Act; tort law; contract law; wrongful discharge; discrimination; harassment; 
fraud; defamation; emotional distress; and breach of the implied covenant of 
good faith and fair dealing.

         You further acknowledge that you are knowingly and voluntarily 
waiving and releasing any rights you may have under the Age Discrimination in 
Employment Act of 1967 ("ADEA").  You also acknowledge that the consideration 
given for the waiver and release in the preceding paragraphs hereof is in 
addition to anything of value to which you were already entitled.  You hereby 
provide the further acknowledgment that you are advised by this writing, as 
required by the Older Workers Benefit Protection Act, that: (a) your waiver 
and release do not apply to any rights or claims that may arise after the 
Effective Date of this release; (b) you have the right to consult with an 
attorney prior to executing this release (although you may voluntarily choose 
not to do so); (c) you may have at least twenty-one (21) days to consider 
this Agreement (although you may by your own choice execute this release 
earlier); (d) you have seven (7) days following the execution of this release 
to revoke this release; and (e) this Agreement shall not be effective until 
the date upon which the revocation period has expired, therefore making the 
effective date the eighth day after this release is signed by you (the 
"Effective Date").

14.      In giving this release, which includes claims which may be unknown 
to you at present, you hereby acknowledge that you have read and understand 
Section 1542 of the Civil Code of the State of California which reads as 
follows:

<PAGE>

William C. Ripka, Ph.D.
September 23, 1997
Page 4

         A general release does not extend to claims which the 
         creditor does not know or suspect to exist in his favor 
         at the time of executing the release, which if known by 
         him must have materially affected his settlement with 
         the debtor.

         You hereby expressly waive and relinquish all rights and benefits 
under this section and any law or legal principle of similar effect in any 
jurisdiction with respect to claims released hereby.

15.      In the event of any litigation arising out of or relating to this 
Agreement, its breach or enforcement, including an action for declaratory 
relief, the prevailing party in such action or proceeding shall be entitled 
to receive his or its damages, court costs, and all out-of-pocket expenses, 
including attorneys fees.  Such recovery shall include court costs, 
out-of-pocket expenses, and attorneys fees on appeal, if any.

16.      The parties hereto hereby acknowledge that this is a compromise 
settlement of various matters, and that the promised payments in 
consideration of this Agreement shall not be construed to be an admission of 
any liability or obligation by either party to the other party or to any 
other person whomsoever.

17.      This Agreement, including Exhibit A and B, constitutes the complete, 
final and exclusive embodiment of the entire agreement between you and the 
Company with regard to the subject matter hereof.  It is entered into without 
reliance on any promise or representation, written or oral, other than those 
expressly contained herein.  It may not be modified except in a writing 
signed by you and a duly authorized officer of the Company.  Each party has 
carefully read this Agreement, has been afforded the opportunity to be 
advised of its meaning and consequences by his or its respective attorneys, 
and signed the same of his or its free will.

18.      This Agreement shall bind the heirs, personal representatives, 
successors, assigns, executors, and administrators of each party, and inure 
to the benefit of each party, its agents, directors, officers, employees, 
servants, heirs, successors and assigns.

19.      This Agreement shall be deemed to have been entered into and shall 
be construed and enforced in accordance with the laws of the State of 
California as applied to contracts made and to be performed entirely within 
California.

20.      If a court of competent jurisdiction determines that any term or 
provision of this Agreement is invalid or unenforceable, in whole or in part, 
then the remaining terms and provisions hereof shall be unimpaired.  Such 
court will have the authority to modify or replace the invalid or 
unenforceable term or provision with a valid and enforceable term or 
provision that most accurately represents the parties' intention with respect 
to the invalid or unenforceable term or provision.

21.      This Agreement may be executed in two counterparts, each of which 
shall be deemed an original, all of which together shall constitute one and 
the same instrument.

<PAGE>

William C. Ripka, Ph.D.
September 23, 1997
Page 5

Please confirm your assent to the foregoing terms and conditions of our 
Agreement by signing and returning this letter to me. 

Sincerely,

CORVAS INTERNATIONAL, INC.


/s/ RANDALL E. WOODS
- -----------------------------
Randall E. Woods
President and Chief Executive Officer


HAVING READ AND REVIEWED THE FOREGOING, I HEREBY AGREE TO AND ACCEPT THE 
TERMS AND CONDITIONS AS STATED ABOVE.

Dated: SEPT. 26, 1997                  /s/ WILLIAM C. RIPKA, Ph.D.
       ---------------                 ------------------------------
                                       William C. Ripka, Ph.D.




<TABLE> <S> <C>

<PAGE>
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<S>                             <C>
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<PERIOD-END>                               SEP-30-1997
<CASH>                                           1,431
<SECURITIES>                                    24,355
<RECEIVABLES>                                      602
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<CURRENT-ASSETS>                                26,955
<PP&E>                                           4,790
<DEPRECIATION>                                   3,434
<TOTAL-ASSETS>                                  28,311
<CURRENT-LIABILITIES>                            4,540
<BONDS>                                              0
                                0
                                          1
<COMMON>                                            14
<OTHER-SE>                                      23,756
<TOTAL-LIABILITY-AND-EQUITY>                    28,311
<SALES>                                            240
<TOTAL-REVENUES>                                 8,493
<CGS>                                              130
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</TABLE>


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