CORVAS INTERNATIONAL INC
SC 13G/A, 1998-03-05
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G


                    Under the Securities Exchange Act of 1934
                                (Amendment No. 3)


                           Corvas International, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                    Common Stock, par value $0.001 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   221005-10-1
- --------------------------------------------------------------------------------
                                 (CUSIP Number)




                                   Page 1 of 6

<PAGE>



- ------------------------                              --------------------------
CUSIP No. 221005-10-1                  13G                 Page 2 of 6 Pages
- ------------------------                              --------------------------

- --------------------------------------------------------------------------------
1      NAME OF REPORTING PERSON
       S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

              PGS International N.V., a Netherlands Corporation
- --------------------------------------------------------------------------------
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP            (a)      |_|
                                                                 (b)      |X|
- --------------------------------------------------------------------------------
3    SEC USE ONLY

- --------------------------------------------------------------------------------
4    CITIZENSHIP OR PLACE OF ORGANIZATION

              Netherlands
- --------------------------------------------------------------------------------
                          5        SOLE VOTING POWER
                          
  NUMBER OF         ------------------------------------------------------------
    SHARES                6        SHARED VOTING POWER
  BENEFICIAL                      
   LY OWNED                                 See Items 4 and 6
   BY EACH          ------------------------------------------------------------
  REPORTING               7        SOLE DISPOSITIVE POWER
    PERSON                
     WITH           ------------------------------------------------------------
                          8       SHARED DISPOSITIVE POWER
                          
                                            See Items 4 and 6
- --------------------------------------------------------------------------------
9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

              1,169,793 Shares of Common Stock/Held by indirect and direct
              subsidiaries.

- --------------------------------------------------------------------------------
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                 |_|
- --------------------------------------------------------------------------------
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

              8.4%
- --------------------------------------------------------------------------------
12   TYPE OF REPORTING PERSON

              CO
- --------------------------------------------------------------------------------


                                   Page 2 of 6

<PAGE>



                          ITEMS 1-10 OF AMENDMENT NO. 3
                         AND RESTATEMENT OF SCHEDULE 13G
                           OF PGS INTERNATIONAL N.V.,
                            A NETHERLANDS CORPORATION

              This restated Schedule 13G is being filed by PGS International
N.V., a Netherlands corporation ("PGS Netherlands") to report the sale of
165,000 shares of Common Stock of Corvas International, Inc. (the "Company")
(the "Shares") by Chelsea N.V. ("Chelsea") and thereby reducing the beneficial
ownership of PGS Netherlands from 1,334,793 Shares to 1,169,793 Shares.

              On February 12, 1993, Plant Genetic Systems, N.V., a Belgian
corporation ("PGS") filed a Schedule 13G to report beneficial ownership of
1,334,793 Shares. The Shares were held through Chelsea, a wholly owned
subsidiary of PGS. Through Chelsea, PGS had sole power to direct the vote and to
direct the disposition of the Shares.

              The Schedule 13G was amended on February 16, 1994 to report the
sale of 300,000 Shares by Chelsea to PGS International N.V., a Belgian
corporation ("PGS Belgium"). PGS Belgium owns 100% of the stock of PGS. The
Amendment No. 1 to the Schedule 13G specified that PGS Netherlands was organized
in November 1993 through a share exchange by the shareholders of PGS Belgium and
exercised sole voting and investment control over the Shares still held by
Chelsea and PGS Belgium.

              The Schedule 13G was amended on February 3, 1997 to report the
acquisition of PGS Netherlands by Hoechst Schering AgrEvo GmbH, a German
corporation ("Hoechst Schering AgrEvo"). Hoechst Schering AgrEvo was a
joint-venture owned by Hoechst AG ("Hoechst") and Schering AG ("Schering"). Both
Hoechst and Schering were German corporations. The Amendment No. 2 to the
Schedule 13G specified that as a result of the acquisition by Hoechst Schering
AgrEvo, PGS Netherlands was no longer PGS Belgium's and Chelsea's ultimate
parent company. PGS Netherlands became a wholly owned subsidiary of Hoechst
Schering AgrEvo. PGS Netherlands was still holding the Shares through Chelsea
and PGS Belgium, but was sharing voting and investment control over the Shares
with its direct parent company Hoechst Schering AgrEvo.

Item 1.        Name of Issuer.

(a) -- (b)     The issuer is Corvas International, Inc. and has its principal
               executive offices at 3030 Science Park Road, San Diego,
               California  92121.

Item 2.        Name of Filing Person.

(a)            This restated statement on Schedule 13G is being filed by PGS
               International N.V.


                                   Page 3 of 6

<PAGE>



(b)            The address of the principal business office of PGS International
               N.V. is Diemerhof 36, 1112 XN Diemen, The Netherlands.

(c)            PGS International N.V. is a Netherlands corporation.

(d)            This Statement refers to the Common Stock of Corvas
               International, Inc.

(e)            The CUSIP number is 221005-10-1.

Item 3.        Filings Pursuant to Rule 13d-1(b) or 13d-2(b).

               Not applicable.

Item 4.        Ownership.

(a)            PGS Netherlands shares power to direct the vote and to direct the
               disposition of the aggregate 1,169,793 Shares described herein
               with its parent company. 869,793 Shares are held directly by
               Chelsea and 300,000 Shares are held directly by PGS Belgium.

(b)            The aggregate 1,169,793 Shares held by Chelsea and PGS Belgium
               represent 8.4% of the outstanding shares of the Company's Common
               Stock. Percentage ownership of the Company's Common Stock is
               based on the number of outstanding shares of Common Stock as
               reported in the Company's Form 10-Q for the quarter ended
               September 30, 1997.

(c)            As mentioned above, PGS Netherlands shares voting and investment
               power with its direct parent company Hoechst Schering AgrEvo.

Item 5.        Ownership of Five Percent or Less of a Class.

               Not applicable.

Item 6.        Ownership of More than Five Percent on Behalf of Another Person.

               As stated in Item 4 above, PGS Netherlands holds 8.4% of the
               Common Stock through PGS Belgium and Chelsea, of which it is a
               parent company. PGS Netherlands is a wholly owned subsidiary of
               Hoechst Schering AgrEvo, a German corporation owned by Hoechst AG
               and Schering AG.


                                   Page 4 of 6

<PAGE>



Item 7.        Identification and Classification of the Subsidiary Which
               Acquired the Security Being Reported on By the Parent Holding
               Company.

               Not applicable.

Item 8.        Identification and Classification of Members of the Group.

               Not applicable.

Item 9.        Notice of Dissolution of Group.

               Not applicable.

Item 10.       Certification.

               Not applicable.


                                   Page 5 of 6

<PAGE>


                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this Statement is true,
complete and correct.

                                               PGS INTERNATIONAL N.V.


Date:         March  5, 1998                   By: /s/ Jan Leemans
                                                  ------------------------------
                                                   Name: JAN LEEMANS
                                                   Title:  MANAGING DIRECTOR



                                   Page 6 of 6


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