CORVAS INTERNATIONAL INC
10-Q, 1998-08-12
PHARMACEUTICAL PREPARATIONS
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<PAGE>
                                     FORM 1O-Q

                         SECURITIES AND EXCHANGE COMMISSION
                               Washington, D.C. 20549
(Mark One)

      [X]  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
      EXCHANGE ACT OF 1934
      For the quarterly period ended June 30, 1998

                                      OR

      [ ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
      EXCHANGE ACT OF 1934
      For the transition period from _________  to  ___________

      Commission file number 0-19732

                         CORVAS INTERNATIONAL, INC.
        (Exact name of Registrant as specified in its charter)

           DELAWARE                               33-0238812
  (State or other jurisdiction                 (I .R.S. Employer
of incorporation or organization)              Identification No.)
                                       
                             3030 SCIENCE PARK ROAD
                          SAN DIEGO, CALIFORNIA 92121
            (Address of principal executive offices and zip code)

                               (619) 455-9800
            (Registrant's telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act: None

Securities registered pursuant to Section 12(g) of the Act:

                        Common Stock, $0.001 par value
                              (Title of class)

      Indicate by check mark whether the Registrant (l) has filed all reports 
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 
1934 during the preceding 12 months (or for such shorter period that the 
Registrant was required to file such reports), and (2) has been subject to 
such filing requirements for the past 90 days.

               Yes  /x/  No   
                  ------    ------

       At July 31, 1998, there were 15,085,575 shares of Common Stock, $0.001 
par value, of the Registrant issued and outstanding.


<PAGE>
                                      
                          CORVAS INTERNATIONAL, INC.

                                    INDEX
<TABLE>
<CAPTION>

                                                                              Page
                                                                              ----
<S>                                                                           <C>

                      PART I   FINANCIAL INFORMATION

Item 1         Financial Statements

               Condensed Balance Sheets as of June 30, 1998 (unaudited)  
               and December 31, 1997                                             1

               Unaudited Condensed Statements of Operations for the Three     
               and Six Months Ended June 30, 1998 and 1997                       2

               Unaudited Condensed Statements of Cash Flows for the 
               Six Months Ended June 30, 1998 and 1997                           3

               Notes to Condensed Financial Statements                           4

Item 2         Management's Discussion and Analysis of Financial
               Condition and Results of Operations                               5

Item 3         Quantitative and Qualitative Disclosures About Market Risk        9


                    PART II    OTHER INFORMATION

Item 1         Legal Proceedings                                                10

Item 2         Changes in Securities                                            10
                   None

Item 3         Defaults Upon Senior Securities                                  10
                   None

Item 4         Submission of Matters to a Vote of Security Holders              10

Item 5         Other Information                                                11
                   None

Item 6         Exhibits and Reports on Form 8-K                            
               (a)    Exhibits                                                  11
                      
               (b)    Reports on Form 8-K                                       11
                      None

SIGNATURES                                                                      12
</TABLE>






<PAGE>
                                       
                        PART I -- FINANCIAL INFORMATION 

 Item 1.  FINANCIAL STATEMENTS 

                          CORVAS INTERNATIONAL, INC.
                           CONDENSED BALANCE SHEETS
                                (In thousands)

<TABLE>
<CAPTION>

                                                    JUNE 30, 1998       DECEMBER 31, 1997 
                                                    -------------       -----------------
                                                     (unaudited)
 <S>                                                <C>                 <C>
 ASSETS 

 Current assets: 
     Cash and cash equivalents                          $  3,541             $  2,044 
     Short-term debt securities held to maturity  
         and time deposits, partially restricted          16,933               24,076 
     Receivables                                             258                  289 
     Notes receivable from related parties                   153                  153 
     Other current assets                                    354                  340 
                                                        --------             --------
         Total current assets                             21,239               26,902 

 Property and equipment, net                               1,662                1,312 
                                                        --------             --------
                                                        $ 22,901             $ 28,214 
                                                        --------             --------
                                                        --------             --------
 LIABILITIES AND STOCKHOLDERS' EQUITY 

 Current liabilities: 
     Accounts payable                                   $    483             $    299 
     Accrued expenses                                      1,151                  623 
     Accrued vacation                                        237                  191 
     Deferred revenue                                      2,000                4,656 
                                                        --------             --------
         Total current liabilities                         3,871                5,769 
                                                        --------             --------

 Stockholders' equity: 
     Preferred stock - Series A                                1                    1 
     Preferred stock - Series B                                -                    - 
     Common stock                                             14                   14 
     Additional paid-in capital                           92,521               92,179 
     Accumulated deficit                                 (73,506)             (69,749)
                                                        --------             --------
         Total stockholders' equity                       19,030               22,445 
                                                        --------             --------
 Commitments and contingencies                          $ 22,901             $ 28,214 
                                                        --------             --------
                                                        --------             --------
</TABLE>


      See accompanying notes to condensed financial statements.

                                      1

<PAGE>

                          CORVAS INTERNATIONAL, INC.

                      CONDENSED STATEMENTS OF OPERATIONS
               In thousands, except per share amounts (unaudited)


<TABLE>
<CAPTION>
  
                                                   Three Months Ended       Six Months Ended
                                                        June 30,                 June 30,
                                                 ----------------------    ---------------------
                                                   1998          1997        1998         1997
                                                 ---------     --------    --------    ---------
<S>                                              <C>          <C>          <C>         <C>
REVENUES:
  Revenue from collaborative agreements          $  1,746     $  1,244    $  3,493     $  2,319
  License fees and milestones                       1,000          250       2,000        4,100
  Net product sales                                    10          153          44          163
  Royalties                                            53           21          95           57
                                                 --------     --------    --------     --------
     Total revenues                                 2,809        1,668       5,632        6,639
                                                 --------     --------    --------     --------
COSTS AND EXPENSES:
  Research and development                          4,098        2,693       7,682        5,042
  General and administrative                        1,400        1,391       2,266        2,239
  Cost of products sold                                 1           74          18           78
                                                 --------     --------    --------     --------
     Total costs and expenses                       5,499        4,158       9,966        7,359
                                                 --------     --------    --------     --------

     Loss from operations                          (2,690)      (2,490)     (4,334)        (720)

OTHER INCOME:
  Interest income, net                                245          327         572          715
  Other income                                          5            0           5         _  
                                                 --------     --------    --------     --------
                                                      250          327         577          715
                                                 --------     --------    --------     --------
     Net loss                                    $ (2,440)    $ (2,163)   $ (3,757)     $    (5)
                                                 --------     --------    --------     --------
                                                 --------     --------    --------     --------
     Basic and diluted net loss 
       per share                                 $  (0.18)    $  (0.15)   $  (0.27)     $ (0.00)
                                                 --------     --------    --------     --------
                                                 --------     --------    --------     --------
    Shares used in calculation of  
       net loss per share                          14,038       13,850      14,005       13,832
                                                 --------     --------    --------     --------
                                                 --------     --------    --------     --------
</TABLE>

See accompanying notes to condensed financial statements.


                               2

<PAGE>
                                       
                          CORVAS INTERNATIONAL, INC.
                      CONDENSED STATEMENTS OF CASH FLOWS
                           IN THOUSANDS (UNAUDITED)

<TABLE>
<CAPTION>
                                                      Six Months Ended 
                                                          June 30, 
                                                  -------------------------
                                                      1998          1997
                                                  ----------      --------
<S>                                               <C>              <C>
 Cash flows from operating activities:   
  Net loss                                        $  (3,757)       $  (5)
  Adjustments to reconcile net loss to 
  net cash used in operating activities: 
     Depreciation and amortization                      303          311 
     Amortization of premiums and discounts 
       on investments                                  (460)          26 
  Loss on sale of property and equipment                 81            0
     Stock compensation expense                         104            6 
     Change in assets and liabilities: 
       Decrease in receivables                           31          202 
       Increase in other current assets                 (14)        (416)
       Increase in accounts payable, accrued 
         expenses and accrued vacation                  758          426 
       Decrease in deferred revenue                  (2,656)        (556)
                                                    -------      -------
       Net cash used in operating activities         (5,610)          (6)
                                                    -------      -------
 Cash flows from investing activities: 
  Purchases of investments held to maturity         (19,693)     (27,329)
  Proceeds from maturity of investments 
     held to maturity                                27,295       26,485 
  Purchases of property and equipment                  (733)        (803)
                                                    -------      -------
       Net cash provided by (used in) 
         investing activities                         6,869       (1,647)
                                                    -------      -------
 Cash flows from financing activities: 
  Principal payments under capital lease 
    obligation                                            0         (20)
  Net proceeds from issuance of common stock            238         332 
                                                    -------      -------
       Net cash provided by financing activities        238         312 
                                                    -------      -------

 Net increase (decrease) in cash and cash 
  equivalents                                         1,497      (1,341)

 Cash and cash equivalents at beginning of period     2,044       2,202 
                                                    -------      -------
 Cash and cash equivalents at end of period        $  3,541      $  861 
                                                   --------      -------
                                                   --------      -------

</TABLE>


 See accompanying notes to condensed financial statements.


                                    3 



<PAGE>
              
                             CORVAS INTERNATIONAL, INC.
                                          
                      NOTES TO CONDENSED FINANCIAL STATEMENTS
                                    (UNAUDITED)

(1)  THE COMPANY

     Corvas International, Inc. (the "Company") was incorporated on March 27,
1987 under the laws of the State of California.  In July 1993, the Company
reincorporated in the State of Delaware.  The Company is engaged in the design
and development of a new generation of therapeutic agents in the fields of blood
clot formation (thrombosis), inflammation, cancer and other diseases.

(2)  BASIS OF PRESENTATION

     The interim financial information contained herein is unaudited but, in
management's opinion, includes all adjustments, consisting only of normal
recurring adjustments, necessary for a fair presentation.  The financial
statements should be read in conjunction with the Company's audited financial
statements and notes thereto for the year ended December 31, 1997.  Results for
the interim periods are not necessarily indicative of results for other interim
periods or for the full year.

(3)  NET LOSS PER SHARE

     Net loss per share for the three and six months ended June 30, 1998 and
1997 is computed using the weighted average number of common share equivalents
outstanding.  Common equivalent shares are not included in the per share
calculation since the effect of their inclusion would be anti-dilutive.

 (4)  COMPREHENSIVE INCOME

     As of January 1, 1998, the Company adopted Statement of Financial
Accounting Standards No. 130, "Reporting Comprehensive Income" ("SFAS 130"). 
SFAS 130 established standards for reporting and display of comprehensive income
and its components in a full set of general-purpose financial statements.  The
adoption of SFAS 130 did not have a significant impact since the Company's net
loss approximates comprehensive loss for the six month periods ended June 30,
1998 and 1997.

(5)  SUBSEQUENT EVENTS

     On July 21, 1998, the Company issued a total of 1,025,000 shares of common
stock pursuant to the exercise of warrants by a select group of institutional
investors, resulting in estimated net proceeds of $3,646,000. 

 
                                       4
<PAGE>

Item 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS

     EXCEPT FOR THE HISTORICAL INFORMATION CONTAINED HEREIN, THE FOLLOWING 
DISCUSSION CONTAINS FORWARD-LOOKING STATEMENTS THAT INVOLVE RISKS AND 
UNCERTAINTIES.  THE COMPANY'S ACTUAL RESULTS COULD DIFFER MATERIALLY FROM 
THOSE PROJECTED IN THE FORWARD-LOOKING STATEMENTS.  FACTORS THAT COULD CAUSE 
OR CONTRIBUTE TO SUCH DIFFERENCES INCLUDE, BUT ARE NOT LIMITED TO, THOSE 
DISCUSSED IN THE COMPANY'S ANNUAL REPORT ON FORM 10-K.

OVERVIEW

     Formed in 1987, Corvas International, Inc. (the "Company") is a 
biopharmaceutical firm engaged in the design and development of a new 
generation of therapeutic agents in the fields of blood clot formation 
(thrombosis), inflammation, cancer and other diseases.  To date, the Company 
has not generated significant revenues from product sales.  The Company has 
not been profitable on an annual basis since inception and expects to incur 
substantial additional operating losses on an annual basis over the next 
several years as the Company expands its research and development programs.  
There is no assurance that the Company will successfully develop, 
commercialize, manufacture or market its products or generate sufficient 
revenues to become profitable on a sustained basis or at all.  At June 30, 
1998, the Company had an accumulated deficit of $73,506,000.

RESULTS OF OPERATIONS

THREE MONTHS ENDED JUNE 30, 1998 AND 1997

     Operating revenues increased from $1,668,000 for the quarter ended June 
30, 1997 to   $2,809,000 in the corresponding period in 1998.  This increase 
is primarily the result of a $1,000,000 milestone received from Schering 
Corporation ("Schering-Plough") upon the commencement of a Phase I trial of 
an oral antithrombotic drug candidate discovered by Corvas.  Also 
contributing to this increase is $240,000 of revenue from collaborative 
agreements recognized pursuant to the Company's research and development 
agreement with Vascular Genomics Inc. ("VGI") covering a novel vascular 
targeting technology.   These increases were partially offset by a decrease 
in net product sales.  The Company has discontinued its manufacturing 
activities related to recombinant tissue factor and expects to complete the 
transfer of these activities to Ortho-Clinical Diagnostics Inc. ("Ortho"), a 
Johnson & Johnson company, during the third quarter of 1998. 

     Total  costs and expenses increased from $4,158,000 in the three months 
ended June 30, 1997 to $5,499,000 in the same period of 1998.  Research and 
development expenses accounted for the majority of this increase, increasing 
from $2,693,000 in the second quarter of 1997 to $4,098,000 in the same 
quarter one year later.  This increase is primarily due to increased costs 
associated with three clinical studies of NAPc2 and clinical supplies 
manufacturing of NAP5.  General and administrative costs increased only 
slightly comparing these periods.  These increases were partially offset by a 
$73,000 decrease in cost of goods sold resulting from the Company's 
discontinuation of all manufacturing activities.   

     Other income decreased from $327,000 in the three month period ended June
30, 1997 to $250,000 in the corresponding period of 1998 due to a reduction in
interest income earned, primarily as a result of a decrease in investment
securities.


                                       5
<PAGE>

SIX MONTHS ENDED JUNE 30, 1998 AND 1997

     Comparing the six month periods ended June 30, operating revenues 
decreased by $1,007,000 from $6,639,000 in 1997 to $5,632,000 in 1998.  This 
decrease is primarily the result of a $3,000,000 milestone earned in the 
oral thrombin inhibitor program with Schering-Plough in the first half of 
1997, compared to a $1,000,000 milestone earned in the first half of 1998.  
Net product sales also decreased comparing these periods, from $163,000 to 
$44,000, due to discontinuing the manufacturing of recombinant tissue factor. 
These decreases were partially offset by an increase of $1,174,000 in 
revenue from collaborative agreements.  The increase in this line item is 
mainly the result of revenue recognized pursuant to a third collaboration 
with Schering-Plough, covering oral inhibitors of a key protease necessary 
for hepatitis C virus replication, and the research and development agreement 
with VGI, both of which were entered into in mid-1997.  

     Total costs and expenses increased by $2,607,000 comparing the first 
half of 1997 to 1998, from $7,359,000 in the 1997 period to $9,966,000 in the 
1998 period.  Research and development expenses associated with the NAPc2 and 
NAP5 programs accounted for the majority of this increase, increasing from 
$5,042,000 to $7,682,000, while general and administrative expenses increased 
by a modest $27,000.  A $60,000 decrease in cost of goods sold related to the 
discontinuation of recombinant tissue factor manufacturing offset a portion 
of this increase in expenses.

     Total other income decreased from $715,000 in the first six months of 
1997 to $577,000 in the same period one year later, primarily as a result of 
decreased cash balances available for investment which caused interest income 
to decrease by $143,000.   

     Subject to the availability of additional capital, the Company expects 
its expenses to increase over the next several years as the Company's 
research and development programs progress.  The Company also expects both 
its expenses and losses to fluctuate from quarter to quarter and anticipates 
that such fluctuations may, at times, be substantial.   
 
LIQUIDITY AND CAPITAL RESOURCES

     Since inception, the Company's operations have been funded primarily 
through public offerings and private placements of equity securities, 
revenues and milestones from collaborative agreements, license fees and 
research grants, and interest income earned on cash and investment balances. 
The Company's principal sources of liquidity are its cash and cash 
equivalents, time deposits and debt securities which, net of a restricted 
time deposit, totaled $20,414,000 as of June 30, 1998. Working capital at 
June 30, 1998 was $17,368,000. Subsequent to June 30, 1998, the Company 
raised estimated net proceeds of $3,646,000 from the exercise of certain 
warrants.  Available cash is invested in accordance with an investment policy 
set by the Board of Directors, which has the objectives to preserve 
principal, maintain adequate liquidity and maximize income.  The policy 
provides guidelines concerning the quality, term and liquidity of 
investments.  The Company presently invests its excess cash in 
interest-bearing, investment-grade securities.

     Net cash used in operations in the six months ended June 30, 1998 was 
$5,610,000, compared to $6,000 for the same period one year earlier.  This 
was due to increased cash usage as the Company continues its efforts in the 
clinical development of NAPc2 and NAP5, as well as a decrease in 1998 
operating revenues, mainly as a result of the $3,000,000 milestone payment 
received from Schering-Plough in the first quarter of 1997.  In the six 
months ended June 30, 1998, net cash of $6,869,000 was provided by investing 
activities, compared to net cash of $1,647,000 used in investing activities 
in the corresponding period of 1997. This reflects the usage of proceeds from 
investment maturities to fund 1998 operating activities.  Net cash provided 
by financing activities decreased slightly to $238,000 from $312,000 in the 
same period one year earlier due to the exercise of fewer stock options in 
1998.    


                                       6
<PAGE>

     The Company expects to incur substantial additional costs in the 
foreseeable future, including costs related to clinical and preclinical 
studies and expanding its research and development activities.  The Company 
expects such costs to continue to increase and, as a result, expects to 
experience substantial additional operating losses and negative cash flows 
from operations over the next several years.  In particular, increased costs 
are anticipated as the clinical development of NAPc2 progresses, including a 
Phase II trial planned to commence in late 1998.  The Company also expects 
revenues in 1999 to decrease from the current levels due to reaching the end 
of the two-year term in the Factor Xa research program with Schering-Plough.  
The Company believes its existing capital resources and interest earned 
thereon should be sufficient to satisfy its anticipated funding requirements 
for at least the next 12 months. In addition, the Company may also receive 
additional funds through milestone payments and royalties on sales of 
products in connection with its alliances. However, there is no assurance 
that the Company will receive any additional amounts under existing or any 
future alliances. 

     Strategic collaborations with Schering-Plough and Pfizer provide for 
payments to the Company if and when certain milestones are met.  However, 
there is no assurance that any future milestones will be achieved.  In the 
quarter ended June 30, 1998, Schering-Plough initiated a clinical trial in 
the oral thrombin inhibitor program which triggered a $1,000,000 milestone 
payment.  The next milestone payment expected, in another of the Company's 
collaborations with Schering-Plough, is $500,000 upon the identification of 
an initial lead compound in the program covering inhibitors of the hepatitis 
C virus.  In addition, the Company may also receive additional milestone 
payments and royalties on sales of products in connection with its existing 
alliances, as well as from any future alliances.  If all of the milestones on 
all of the Company's existing collaborations are met, Corvas could receive a 
maximum of $94,431,000 in future milestone payments and research and 
development funding over the next several years.   There is no assurance that 
the Company's existing collaborations will be successful, that the Company 
will receive any further milestones or other payments pursuant to 
collaborative agreements, that the collaborations will continue since the 
existing collaborative agreements are terminable at the option of the 
collaborator upon certain events or that the existing collaborations will be 
commercially successful.  

     In June 1997, the Company entered into an option agreement with VGI
pursuant to which the Company has the option through June 2000 to acquire all of
the stock of VGI in exchange for Corvas Common Stock or, in certain
circumstances at the option of the Company, a combination of cash and 633,600
shares of Common Stock.  The aggregate acquisition price, which is based on the
timing of option exercise, ranges from a minimum of $14,863,000 as of June 30,
1998 to a maximum of $19,960,000.  If this option is exercised, the Company
expects a noncash charge to earnings for in-process research and development. 
If Corvas elects not to exercise its option, VGI may require the Company to
purchase 19.9% of its outstanding stock for $3,960,000 in Corvas Common Stock. 
During the option period, Corvas will make monthly option payments of
approximately $83,000 to VGI.  In addition, under a research and development
agreement, VGI is required to make monthly payments of $80,000 to Corvas to be
applied to research and development covering the VGI technology.  Although the
net impact of these payments is not material, the Company may incur substantial
additional costs to develop this technology.  Corvas may enter into one or more
collaborative relationships to develop and commercialize this technology. 
However, there is no assurance that the Company will be able to establish such
relationships on satisfactory terms, that such relationships will successfully
reduce the costs associated with research and development of this technology,
that the option will be exercised or that this technology will prove to be
effective.   


                                       7
<PAGE>

     Future capital requirements of the Company will depend on many factors, 
including, but not limited to, the following: the continued scientific 
progress in its drug discovery programs; the magnitude of such programs; the 
progress and results of preclinical testing and clinical trials; the costs 
involved in complying with the regulatory process; the costs involved in 
filing, prosecuting, maintaining and enforcing patent claims; the competing 
technological and market developments; the changes in its existing research 
relationships; the ability of the Company to establish and  maintain 
collaborative or licensing arrangements; the cost of manufacturing scale-up; 
and the  effectiveness of activities and arrangements of the Company or its 
collaborative partners to commercialize the Company's products.  The Company 
leases its laboratory and office facilities under an operating lease which 
will expire in September 1999.  The Company is presently in the process of 
evaluating its alternatives with respect to its facilities, including the 
possibility of expanding its existing space.  

     To continue its long-term product development efforts, the Company must 
raise substantial additional funding either through collaborative 
arrangements or through public or private financings.  The Company's ability 
to raise additional funds through such sales of securities depends in part on 
investors' perceptions of the biotechnology industry, in general, and of the 
Company, in particular.  The market prices for securities of biotechnology 
companies, including Corvas, have historically been highly volatile and, 
accordingly, there is no assurance that additional funding will be available, 
or, if available, that it will be available on acceptable terms.  If 
additional funds are raised by issuing securities, further dilution, possibly 
substantial, to existing stockholders will likely result.  The Company may 
enter into additional collaborative relationships to develop and 
commercialize certain of its current or future technologies or products.  
There is no assurance that the Company will be able to establish such 
relationships on satisfactory terms, if at all, or that agreements with 
collaborators will successfully reduce the Company's funding requirements.  
In addition, the Company has not attempted to establish bank financing 
arrangements, and there is no assurance that it would be able to establish 
such arrangements on satisfactory terms, if at all.  If adequate funds are 
not available, the Company may be required to delay, scale back or 
discontinue one or more of its drug discovery programs, clinical trials or 
other aspects of its operations, or obtain funds through arrangements with 
collaborative partners or others that may require the Company to relinquish 
rights to certain of its technologies, product candidates or products that 
the Company would not otherwise relinquish or at prices below that at which 
the Company would otherwise choose to relinquish such rights.

     Many of the world's computer systems currently record years in a 
two-digit format.  Such systems will be unable to properly interpret dates 
beyond the end of 1999, which could lead to business disruptions commonly 
referred to as the "Year 2000" issue.  

     As of June 30, 1998, the Company has only conducted a preliminary review 
of its internal operations and thus has not completed the assessment of its 
Year 2000 issues.  At the present time, the Company is unable to estimate 
what costs may be incurred, but does not expect the costs of this project to 
be material to the Company.

     Although the Company has made a preliminary assessment of its Year 2000
issues, there is no assurance that a complete review of the Company's operations
will not identify additional efforts and costs that will be required which may
have a material adverse effect on the Company.  Furthermore, the Year 2000 issue
is complex and there is no assurance that the Company will be able to address
any problems that may arise from the Year 2000 issue without incurring a
material adverse effect on the Company's business, financial condition or
results of operations.


                                       8
<PAGE>

     In addition, the Company's operations are dependent upon certain third 
parties with which it conducts business, including, but not limited to, its 
corporate partners, suppliers and vendors, as well as certain agencies and 
regulatory organizations.  Although the Company has not yet assessed the Year 
2000 readiness of certain of its key vendors, a team has developed a plan to 
assess such readiness.  There is no assurance that the systems of third 
parties on which the Company relies will be Year 2000 ready or that any such 
failure of a third party would not have a material adverse effect on the 
Company.

     The Company does not yet have a contingency plan to deal with the risks 
related to the Year 2000 issue.  However, the Company anticipates having such 
a plan in place by the end of 1998 to deal with both the risks associated 
with its own Year 2000 issues, as well as those that may be encountered by 
certain third parties with whom the Company conducts business.

     In 1993, the U.S. Patent and Trademark Office (the "USPTO") declared an 
interference to determine the priority of invention between a patent for 
which some rights are licensed to the Company (the "Licensed Patent") and a 
patent application for which rights are held by other parties (the "First 
Patent Application").  In 1996, the USPTO added a second patent application 
to the proceeding (the "Second Patent Application") and redeclared the 
interference. Rights to the Second Patent Application are held by other 
parties, at least some of which also hold rights in the First Patent 
Application.  The subject matter of the patent and these applications is 
recombinant tissue factor, which is used by Ortho to determine the blood 
clotting abilities of patients.  The Company is contesting the other parties' 
claims of prior invention; however, there can be no assurance that the 
Licensed Patent will be upheld.

NEW ACCOUNTING STANDARDS

     In February 1998, Statement of Financial Accounting Standards No. 132, 
"Employers' Disclosures about Pension and Other Retirement Benefits" ("SFAS 
No. 132"), was issued, effective for fiscal years beginning after December 
15, 1997. SFAS 132 standardizes disclosure requirements for pensions and 
other post retirement benefits.  It does not change the measurement or 
recognition provisions for those benefit plans.

     In June 1998, Statement of Financial Accounting Standards No. 133, 
"Accounting for Derivative Instruments and Hedging Activities" ("SFAS 133"), 
was issued, effective for all fiscal quarters of fiscal years beginning after 
June 15, 1999.  SFAS 133 establishes accounting and reporting standards for 
derivative instruments and hedging activities.

     The Company anticipates that the adoption of SFAS Nos. 132 and 133 will 
not have a significant effect on the financial position, results of 
operations or liquidity of the Company. 

Item 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

     Not applicable


                                       9
<PAGE>

                            PART II -- OTHER INFORMATION


Item 1.  LEGAL PROCEEDINGS  

     In 1993, the U.S. Patent and Trademark Office (the "USPTO") declared an 
interference to determine the priority of invention between a patent for 
which some rights are licensed to the Company (the "Licensed Patent") and a 
patent application for which rights are held by other parties (the "First 
Patent Application").  In 1996, the USPTO added a second patent application 
to the proceeding (the "Second Patent Application") and redeclared the 
interference. Rights to the Second Patent Application are held by other 
parties, at least some of which also hold rights in the First Patent 
Application.  The subject matter of the patent and these applications is 
recombinant tissue factor, which is used by Ortho-Clinical Diagnostics Inc. 
("Ortho"), a Johnson & Johnson company,  to determine the blood clotting 
abilities of patients.  The Company is contesting the other parties' claims 
of prior invention; however, there can be no assurance that the Licensed 
Patent will be upheld.     

Item 2.  CHANGES IN SECURITIES

     None

Item 3.  DEFAULTS UPON SENIOR SECURITIES

     None

Item 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

     The annual meeting of stockholders of the Company was held on May 28, 
1998. The matters described below were submitted to a vote of stockholders.  
The Company had 14,014,347 shares of common stock, 1,000,000 shares of Series 
A convertible preferred stock and 250,000 shares of Series B convertible 
preferred stock outstanding as of March 31, 1998, the record date for the 
annual meeting. At the annual meeting, holders of a total of 12,236,542 
shares of common and preferred stock were present in person or represented by 
proxy.
                                          
a.   Election of Class III Directors for a three-year term expiring at the 2001
     annual meeting:

     Name                          Shares voting for         Shares withheld
     ----                          -----------------         ---------------
     M. Blake Ingle, Ph.D.            12,208,462                 28,080
     Randall E. Woods                 12,210,650                 25,892
     R. Douglas Norby                 12,207,264                 29,278
                                          
     Class I Directors continuing in office until the 1999 annual meeting:

      Gerard Van Acker
      W. Leigh Thompson, Jr., M.D., Ph.D.

     Class II Directors continuing in office until the 2000 annual meeting:
          
     John H. Fried, Ph.D.
     Michael Sorell, M.D.
     Nicole Vitullo


                                       10
<PAGE>

b.   A proposal to ratify the appointment of KPMG Peat Marwick LLP as 
     independent auditors for the Company for the fiscal year ending 
     December 31, 1998.

     For                          12,212,603
     Against                           7,707
     Abstain                          16,232


Item 5.  OTHER INFORMATION

      Pursuant to the Company's bylaws, stockholders who wish to bring 
matters or propose nominees for director at the Company's 1999 annual meeting 
of stockholders must provide a notice with specific information to the 
Company and such notice must be delivered to or mailed and received at the 
principal executive offices of the Company no later than the close of 
business on December 16, 1998, which is the 120th day prior to the first 
anniversary of the date specified in the Company's proxy statement released 
in connection with the 1998 annual meeting of stockholders (unless such 
matters are included in the Company's proxy statement pursuant to Rule 14a-8 
under the Securities Exchange Act of 1934, as amended).

                                          
Item 6.  EXHIBITS AND REPORTS ON FORM 8-K

     a. Exhibits

     Exhibit Number                 Description
     --------------                 -----------

         10.65                      Offer to Amend Warrants to Purchase Shares
                                    of Common Stock of the Company, dated
                                    as of June 5, 1998, with certain exhibits
                                    thereto.

         27.1                       Financial Data Schedule.

     b. Reports on Form 8-K

     There were no reports on Form 8-K filed for the quarter ended June 30,
1998.

                                         11

<PAGE>


                                     SIGNATURES


     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this Report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                     CORVAS INTERNATIONAL, INC. 



Date: August 12, 1998                By:  /s/ RANDALL E. WOODS     
                                          -------------------------------------
                                          Randall E. Woods
                                          President and Chief Executive Officer




Date: August 12, 1998                By:  /s/ CAROLYN M. FELZER    
                                          -------------------------------------
                                          Carolyn M. Felzer
                                          Senior Director of Finance
                                          Principal Financial Officer   


                                       12

<PAGE>

                               OFFER TO AMEND
                                WARRANTS TO
                     PURCHASE SHARES OF COMMON STOCK OF
                         CORVAS INTERNATIONAL, INC.

                              --------------

                           THIS OFFER WILL EXPIRE
                            AT 12:00 MIDNIGHT, 
                            CALIFORNIA TIME, ON
                      JULY 20, 1998, UNLESS EXTENDED.

                              --------------

     THIS OFFER TO AMEND WARRANTS (THE "OFFER") IS MADE TO HOLDERS (THE 
"HOLDERS") AS OF JUNE 5, 1998, OF WARRANTS ISSUED PURSUANT TO THAT CERTAIN 
COMMON STOCK AND WARRANT PURCHASE AGREEMENT DATED FEBRUARY 2, 1996 AMONG 
CORVAS INTERNATIONAL, INC. (THE "COMPANY") AND THE PARTIES SET FORTH ON THE 
SCHEDULE OF PURCHASERS THERETO.  THE OFFER IS SUBJECT TO CERTAIN TERMS AND 
CONDITIONS CONTAINED IN THIS MEMORANDUM AND WARRANT EXERCISE AGREEMENT 
ATTACHED HERETO. 
                 
                              --------------
                                          
                                IMPORTANT

     ANY HOLDER DESIRING TO ACCEPT THIS OFFER SHOULD COMPLETE AND RETURN THE 
FOLLOWING FOR DELIVERY NO LATER THAN JULY 19, 1998:

     1.   A duly completed and executed copy of the Warrant Exercise 
Agreement attached hereto or a facsimile thereof in accordance with the 
instructions in the Warrant Exercise Agreement; and

     2.   A cashier's check in the amount equal to the aggregate Amended 
Stock Purchase Price for all shares subject to your fully exercised Warrant.

     ANY HOLDER WISHING TO ACCEPT THE OFFER SHOULD RETURN THE DOCUMENTS 
DESCRIBED ABOVE TO THE ATTENTION OF CAROLYN FELZER AT 3030 SCIENCE PARK ROAD, 
SAN DIEGO, CALIFORNIA 92121 PRIOR TO THE EXPIRATION DATE.  QUESTIONS AND 
REQUESTS FOR ASSISTANCE MAY BE DIRECTED TO CAROLYN FELZER AT THE COMPANY AT 
(619) 455-9800.

     This Offer is conditioned upon the Company's receipt of warrant 
exercises for a minimum of 1,900,000 of the 3,000,000 shares of Common Stock 
subject to the outstanding Warrants ("Minimum Warrant Exercises").  If the 
Company does not receive the Minimum Warrant Exercises prior to the 
Expiration Date, then the Company will return the Warrant Exercise Agreements 
and checks and the Warrants will not be amended in accordance with the Offer.
                 
                             ---------------

DATED:  JUNE 5, 1998


<PAGE>

                                 TABLE OF CONTENTS
<TABLE>

<S>                                                                       <S>
SUMMARY OF TERMS OF OFFER TO AMEND WARRANTS. . . . . . . . . . . . . . . .   1

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   3

1. Terms of the Offer . . . . . . . . . . . . . . . . . . . . . . . . . . .  4

2. Procedure for Accepting Offer and Exercise of Warrant. . . . . . . . . .  4

3. Withdrawal Rights. . . . . . . . . . . . . . . . . . . . . . . . . . . .  5

4. Additional Information . . . . . . . . . . . . . . . . . . . . . . . . .  6

Schedule I --  Schedule of Warrant Holders
Exhibit A  --  Warrant Exercise Agreement
Exhibit B  --  Annual Report on Form 10-K Dated March 31, 1998
Exhibit C  --  Quarterly Report on Form 10-Q Dated May 14, 1998
Exhibit D  --  Description of Common Stock

</TABLE>
                                       i

<PAGE>

                                SUMMARY OF TERMS
                                       OF
                             OFFER TO AMEND WARRANTS   
                                       OF
                            OFFER TO AMEND WARRANTS;

         The following Summary of Terms is qualified in its entirety by the 
more detailed statements in this Offer and attachments hereto.

THE COMPANY                             Corvas International, Inc., a Delaware
                                        corporation.

AMENDMENT OF WARRANTS                   The Company offers to decrease the Stock
                                        Purchase Price (as defined in the
                                        Warrants) to $3.59 per share (as
                                        amended, the "Amended Stock Purchase
                                        Price") for those Warrants that are
                                        fully exercised prior to the Expiration
                                        Date, upon the terms and subject to the
                                        conditions set forth below.

CONDITIONS                              (1) The Stock Purchase Price will only
                                            be amended as to Warrants that are
                                            exercised in their entirety.

                                        (2) The Holder of the Warrant may
                                            transfer all or any portion of the
                                            Warrant as permitted by the Stock
                                            and Warrant Purchase Agreement to
                                            only one transferee who must fully
                                            exercise the transferred Warrant in
                                            order to be entitled to the Amended
                                            Stock Purchase Price.

                                        (3) Unless waived by the Company, the
                                            Company shall have received prior
                                            the Expiration Date (i) duly
                                            completed and executed Warrant
                                            Exercise Agreements covering in the
                                            aggregate at least 1,900,000 shares
                                            of the Company's Common Stock and
                                            (ii) payment in full of the Amended
                                            Stock Purchase Price for such
                                            shares.

                                        (4) The Post-Effective Amendment to the
                                            Registration Statement on Form S-3
                                            registering for resale the shares
                                            acquired upon the exercise of the
                                            amended Warrants must have been
                                            declared effective by the Securities
                                            and Exchange Commission ("SEC") by
                                            no later than the Expiration Date.

EXPIRATION DATE                         12:00 Midnight, California Time, on
                                        July 20, 1998, unless extended by the
                                        Company in accordance with this Offer.

                                      1

<PAGE>

ACCEPTANCE PROCEDURE:                   To accept the Offer you must, prior to
                                        the Expiration Date:

                                        (1) complete, execute and return to the
                                            Company the Warrant Exercise
                                            Agreement; and

                                        (2) remit to the Company a cashier's
                                            check in the amount of the aggregate
                                            Amended Stock Purchase Price for all
                                            of the shares of Common Stock
                                            subject to the exercised Warrant.


                                     2
<PAGE>

                                INTRODUCTION

     To induce the Holders of the Warrants to exercise such Warrants in full, 
the Company hereby offers to reduce the Stock Purchase Price (as defined in 
the Warrants) from $6.00 per share to $3.59 per share for each Warrant that 
is fully exercised prior to the Expiration Date, upon the terms and subject 
to the conditions set forth in this Offer and in the Warrant Exercise 
Agreement.  This Offer is conditioned upon the aggregate exercise of Warrants 
to purchase at least 1,900,000 shares of Common Stock prior to the Expiration 
Date unless the Company waives this condition.  The Offer will be kept open 
until July 20, 1998, unless extended by the Company.  The Company will use 
the proceeds from such exercises for working capital and general corporate 
purposes.  Attached hereto as Schedule I is a list of the Holders as well as 
the number of shares of the Company's Common Stock subject to each such 
Holder's Warrant.  The Company has not obtained commitments from any Holders 
to exercise the Warrants prior to making this Offer.

     While the Board of Directors has voted to approve the Offer, each Holder 
must make its own decision whether to accept the Offer and to purchase the 
Shares subject to such Warrant.  Information about the Company is contained 
in the Company's Annual Report on Form 10-K attached hereto as Exhibit B 
("Form 10-K") and in the Company's Quarterly Report on Form 10-Q attached 
hereto as Exhibit C ("Form 10-Q").  A description of the Common Stock of the 
Company is attached as Exhibit D hereto.

     The Company's Common Stock is quoted and traded on the Nasdaq National 
Market under the symbol CVAS.  On June 4, 1998, the last reported sales price 
of the Common Stock on Nasdaq was $4 3/16.  No public market exists for the 
Warrants and the Warrants are subject to restrictions on transfer.  The 
shares of Common Stock issuable upon exercise of the Warrants ("Shares") will 
be restricted securities.  However, the Company has registered on Form S-3 
the resale by the Warrant Holders of the Shares and, as a condition to the 
Offer and the exercise of the Warrants, the Company will file a 
post-effective amendment to the Registration Statement to update the 
prospectus contained therein.

     THIS OFFER AND THE ATTACHMENTS HERETO CONTAIN IMPORTANT INFORMATION, 
WHICH SHOULD BE READ BEFORE ANY DECISION IS MADE WITH RESPECT TO THE OFFER 
AND ANY PURCHASE OF THE SHARES.  FOR DETAILED DISCUSSION OF THE RISKS 
ASSOCIATED WITH AN INVESTMENT IN THE SHARES, SEE FORM 10-K - RISK FACTORS.


                                   3

<PAGE>

1.   TERMS OF THE OFFER.

     Subject to the terms set forth below, the Company will reduce the Stock 
Purchase Price from $6.00 per share to $3.59 per share as to those Warrants 
that are exercised in full prior to the Expiration Date ("Amended Warrant").  
An Amended Warrant must be exercised in full by (i) the Holder, (ii) by no 
more than one valid transferee of the Warrant provided that the transfer was 
made pursuant to the terms of the Warrant (a "Transferee") OR (iii) by a 
combination of the original Holder and one Transferee of each such Warrant.  
The Offer is expressly conditioned on the Company's receipt prior to the 
Expiration Date of completed and executed Warrant Exercise Agreements by all 
parties exercising Warrants covering at least 1,900,000 Shares of Common 
Stock, unless waived by the Company, and payment in full therefor, on the 
terms set forth herein.  Any Warrant that is not exercised by the Expiration 
Date pursuant to the terms hereof shall remain unamended and continue in full 
force and effect in accordance with its original terms.

     Prior to the Expiration Date, the Company shall file a post-effective 
amendment to the Registration Statement on Form S-3 dated February 28, 1996 
covering the resale of shares of Common Stock acquired upon the exercise of 
Warrants and cause the Post-Effective Amendment to be declared effective by 
the SEC.  In the event the Post-Effective Amendment to the Registration 
Statement is not declared effective by the Expiration Date or any extension 
thereof by the Company, the Offer shall be terminated and the Company shall 
return all payments received by the Company.

     The Company reserves the right, at any time or from time to time, to 
extend the Expiration Date for the purpose of (i) extending the period for 
which payment may be made for fully exercised Warrants, (ii) causing the 
Post-Effective Amendment to the Registration Statement to be declared 
effective or (iii) for any other reason by giving written notice of such 
extension to all Holders.

2.   PROCEDURE FOR ACCEPTING OFFER AND EXERCISE OF WARRANT.

     ACCEPTANCE BY HOLDERS/TRANSFEREES.  For you to validly accept this 
Offer, you (and/or your Transferee) must:

     (1)  complete and execute the Warrant Exercise Agreement as to all Shares
          covered by your Amended Warrant;

     (2)  remit a cashier's check for the aggregate Amended Stock Purchase Price
          for all Shares covered by your exercised Amended Warrant;

     (3)  deliver the completed Warrant Exercise Agreement and payment to the
          Company at its address set forth on page (i) of this Offer PRIOR TO
          THE EXPIRATION DATE.

In the event that you transfer your Warrant pursuant to this Offer, you must
also deliver to the Company prior to the Expiration Date:

     (4)  copies of the duly executed document(s) effecting such transfer; and

     (5)  Items (1) through (3) from the Transferee fully executing the
          transferred Amended Warrant or portion thereof.

No alternative, conditional or contingent responses will be accepted.

     THE METHOD OF DELIVERY OF THE WARRANT EXERCISE AGREEMENT, CASHIER'S CHECK
FOR THE PAYMENT FOR THE SHARES AND ALL OTHER REQUIRED DOCUMENTS, IS AT THE
OPTION AND RISK OF THE ACCEPTING HOLDER.


                                         4

<PAGE>

     ACCEPTANCE BY COMPANY.  Subject to the terms and satisfaction or waiver 
of the conditions hereof, the Company will be deemed to have accepted your 
exercise of the Amended Warrant, if and when (i) the Company gives you 
written notice of the Company's acceptance of such payment OR (ii) the 
Company cashes your check and receives the funds therefrom.  Promptly after 
the acceptance by the Company, and after the Expiration Date, the Company 
will issue certificates representing the Shares pursuant to the Warrant 
Exercise Agreements.

     In the event that the Company does not accept your subscription to the 
Amended Warrant and exercise thereof for any reason including without 
limitation termination or nonoccurrence of a condition to the Offer, the 
Company shall promptly return your payment with a notice stating that your 
Warrant Exercise Agreement was not accepted and that your Warrant was not 
amended.

     DETERMINATIONS OF VALIDITY.  All questions as to the form of documents 
and the validity, eligibility (including time of receipt) and acceptance of 
payment for Shares will be determined by the Company, in its sole discretion, 
and its determination will be final and binding on all parties.  The Company 
reserves the absolute right to reject any or all Warrant Exercise Agreements 
or payments for Shares that are determined by it not to be in proper form.  
The Company also reserves the absolute right to waive any of the conditions 
of the Offer, including, without limitation minimum subscription, mode and 
timing of payment, or any defect or irregularity in any Warrant Exercise 
Agreement delivered to the Company or payment for Shares.  In the event the 
Company, on the Expiration Date, waives any condition of the Offer, it shall 
extend the Expiration Date for at least two days for the purpose of allowing 
you to consider the Offer in light of such waiver; provided, however, that in 
the event that the Company at any time waives the Minimum Warrant Exercise 
the Company shall notice the Holders of such waiver and extend the Expiration 
Date, if necessary, to the date that is 10 business days following the date 
that such notice is first sent to Holders.  The Company's interpretation of 
the terms and conditions of the Offer (including the Warrant Exercise 
Agreement) will be final and binding on all parties.  No Warrant Exercise 
Agreement or payment for Shares will be deemed to have been validly made 
until all defects and irregularities have been cured or waived. The Company 
or any other person will not be under any duty to notify you of any defects 
or irregularities in compliance with the acceptance procedures of this Offer 
or incur any liability for failure to give any such notice.

3.   WITHDRAWAL RIGHTS.

     You may withdraw your acceptance of this Offer at any time prior to the 
Expiration Date.

     For a withdrawal to be effective, a written, telegraphic, telex or 
facsimile transmission notice of withdrawal must be timely received by the 
Company at its address set forth on page (i) of this Offer.  Any notice of 
withdrawal must specify the name of the person who delivered a completed 
Warrant Exercise Agreement and the amount of payment and number of Shares to 
be withdrawn.

     Any exercises of Amended Warrants properly withdrawn will be deemed not 
validly accepted and the subject Warrant shall not be deemed to be amended, 
but may be accepted and exercised at any subsequent time prior to the 
Expiration Date by following the procedures described in Section 2.

     Except as otherwise provided in this Section 3, your acceptance of the 
Offer, including the exercise of your Amended Warrant is irrevocable.


                                      5

<PAGE>

4.   ADDITIONAL INFORMATION.

     The Board of Directors has approved the Offer but has not made any 
recommendation as to whether the Offer should be accepted and the Amended 
Warrants exercised.  Each Holder must make its own decision whether to accept 
this Offer and purchase the Shares subject to the Amended Warrants.  Each 
Holder is recommended to read this Offer and its attachments in their 
entirety.

     No person has been authorized to give any information or to make any 
representations in connection with the Offer other than those contained 
herein. If given or made, such recommendation and such information and 
representations must not be relied upon as having been authorized by the 
Company.

     Holders of Warrants who beneficially own or who would beneficially own 
upon acceptance of the Offer and exercise of the amended Warrants more than 
10% of the Common Stock of the Company are subject to additional restrictions 
on the resale of Shares acquired upon exercise of the Amended Warrants.  The 
exercise of the Amended Warrant will constitute a purchase under Section 16 
of the Securities and Exchange Act of 1934, as amended, and will preclude any 
Holder who is or would be subject to Section 16 from selling any Common Stock 
of the Company for six months following the date of exercise of the Amended 
Warrant. Any Holder who is subject to Section 16 and who has sold any 
securities of the Company during the last six months may be subject to 
liability under Section 16 if such Holder exercises the Amended Warrant.  A 
Holder should consult with its own advisors to determine whether the exercise 
of the Amended Warrant would subject the Holder to any liability.


                                       6

<PAGE>
                                          
                                     SCHEDULE I
                                          
                            SCHEDULE OF WARRANT HOLDERS


<TABLE>
<CAPTION>

 HOLDER                                    COMMON STOCK        AGGREGATE EXERCISE
                                           ISSUABLE UPON             PRICE
                                             EXERCISE 
<S>                                        <C>                  <C>
 International Biotechnology Trust,  plc     1,400,000              $5,026,000
 5 Arrows House
 St. Swithin's Lane
 London EC4N 8NR
 England
 Attn:  Jeremy L. Curnock Cook
 +44-171-623-1000
 +44-171-623-6261 (fax)

 Copy to:
      Rothschild Asset Management,  Ltd.
      One Palmer Square, #515
      Princeton, NJ  08542
      Attn:  Nicole Vitullo
      (609) 683-8009
      (609) 683-4581 (fax)

 AKKAD                                         800,000              $2,872,000
 c/o State Street Bank & Trust
 225 Franklin Street
 Boston, MA 02110
 Attn:  Anna Barnes
 (617) 786-3000

 Copy to: 
      Wanger Asset Management LP
      227 West Monroe, Ste. 3000
      Chicago, IL 60606-5016
      Attn:  John H. Park
      (312) 634-9226
      (312) 634 1904 (fax)

 WPG Institutional Life Sciences Fund, L.P.    120,000                $430,800
 WPG Life Sciences Fund, L.P.                   80,000                $287,200
 One New York Plaza, 30th Floor
 New York, NY 10004-1950
 Attn:  Mike Singer
 (212) 908-9548
 (212) 908-0195 (fax)


                                      S-1

<PAGE>


 Clarion Capital Corporation                    80,000                $287,200
 Clarion Partners, L.P.                         20,000                 $71,800
 1801 East "9th" Street, Ste. 510
 Cleveland, OH 44114
 Attn:  Morton Cohen
        (216) 687-8940
        (216) 694-3545 (fax)

 Framlington Unit-Management -                  85,000               $305,150
   A/C Health Fund
 155 Bishopsgate
 London EC2M3XJ
 England
 Attn:  Antony Milford
     44+171-374-4100
     44+171-330-6648 (fax)

 Copy to:                                                      
           
      C.O. Nominees Limited
           (Registered Owner)
      c/o  Antony Milford
      155 Bishopsgate
      London EC2M3XJ
      England
      44+171-374-4100
      44+171-330-6648 (fax)

 Deliver Stock Certificates and                                
 Warrants to:
         Brown Brothers Harriman
         59 Wall Street
         New York, NY 10006
         Attn:  Maureen Keenan
                (201) 418-6413
                (201) 418-6464 (fax)

 Framlington Investment-Management -            40,000                $143,600
   A/C Selection Sante
 155 Bishopsgate
 London EC2M3XJ
 England
 Attn:  Antony Milford
     44+171-374-4100
     44+171-330-6648 (fax)

 Copy to:                                                      
   Sigler & Co. (Registered Owner)
   4 New York Plaza
   c/o Chemical Bank
   New York, NY 10004
   Attn:  Jerry Reilly
        (212) 623-6274
        (212) 623-1322 (fax)


                                         A-2
<PAGE>

 Deliver Stock Certificates and                                
 Warrants to:
     Chemical Bank
     4 New York Plaza
     New York, NY 10004
     Reference Acct. No. BS6373318
 Attn:  Jerry Reilly
                (212) 623-6274
                (212) 623-1322 (fax)


 SE Banken Fonder AB                           300,000              $1,077,000
 Regeringsgaten 45
 ST R2
 S-106 40 Stockholm
 Sweden
 Attn:  Anders Klintorph
         +46-8-676-9101
         +46-8-676-9148 (fax)

 SE Banken Luxembourg S.A.                     75,000                 $269,250
 c/o SE Banken Fonder AB
 Regeringsgaten 45
 ST R2
 S-106 40 Stockholm
 Sweden
 Attn:  Anders Klintorph
         +46-8-676-9101
         +46-8-676-9148 (fax)

</TABLE>
                                            A-3


<PAGE>

                                         EXHIBIT A

                                 WARRANT EXERCISE AGREEMENT












                                            A-1

<PAGE>

                                CORVAS INTERNATIONAL, INC.

                                WARRANT EXERCISE AGREEMENT
                                      FOR EXERCISE OF
                              WARRANTS TO PURCHASE COMMON STOCK

IF AND WHEN ACCEPTED BY CORVAS INTERNATIONAL, INC. ("COMPANY"), THIS WARRANT 
EXERCISE AGREEMENT, WHEN EXECUTED BELOW, SHALL CONSTITUTE AN ACCEPTANCE OF 
THE WARRANT AMENDMENT AND AN EXERCISE IN FULL OF THE WARRANT.  EACH PART OF 
THIS WARRANT EXERCISE AGREEMENT MUST BE COMPLETED BY THE UNDERSIGNED AND, BY 
THE UNDERSIGNED'S EXECUTION BELOW, THE UNDERSIGNED ACKNOWLEDGES THAT IT 
UNDERSTANDS THAT THE COMPANY IS RELYING UPON THE ACCURACY AND COMPLETENESS 
HEREOF IN COMPLYING WITH ITS OBLIGATIONS UNDER FEDERAL AND STATE SECURITIES 
LAWS.

THE SHARES OF COMMON STOCK OF THE COMPANY TO BE ISSUED UPON THE EXERCISE OF 
THE WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS 
AMENDED, OR ANY STATE SECURITIES LAWS.  SUCH SHARES CANNOT BE SOLD, 
TRANSFERRED, ASSIGNED OR OTHERWISE DISPOSED OF EXCEPT IN COMPLIANCE WITH THE 
RESTRICTIONS ON TRANSFERABILITY UNDER APPLICABLE FEDERAL AND STATE SECURITIES 
LAWS AND WILL NOT BE TRANSFERRED OR RECORDED EXCEPT IN COMPLIANCE WITH SUCH 
LAWS.

          (1)  SUBSCRIPTION.  Subject to the terms and conditions hereof and the
     provisions of the Warrant to Purchase Common Stock of the Company issued
     pursuant to the Common Stock and Warrant Purchase Agreement dated February
     2, 1996 as amended by the Offer to Amend Warrants dated June 5, 1998 (the
     "Warrant"), the undersigned hereby elects to accept the Offer and to
     exercise the Amended Warrant and purchase thereunder _______ shares of
     Common Stock of the Company (the "Shares") at a purchase price of U.S.
     Dollars $3.59 per share and tenders this warrant exercise, together with
     payment by cashier's check in the aggregate amount of $_____________.

          (2)  OFFER TO AMEND WARRANTS.  The undersigned's execution of this
     Warrant Exercise Agreement also constitutes acceptance by the undersigned
     of the Offer to Amend Warrants dated June 5, 1998 (the "Offer").  The
     completion of the Offer is subject to certain additional terms and
     conditions as set forth therein.

          (3)  REPRESENTATIONS AND WARRANTIES OF THE UNDERSIGNED.  The
     undersigned hereby represents and warrants to the Company as follows:

            (a)  AUTHORIZATION.  It has the requisite corporate power to 
enter into this Agreement, to accept the Offer to carry out and perform its 
obligations under the terms of this Warrant Exercise Agreement and to 
purchase the Shares.

            (b)  DUE EXECUTION.  This Warrant Exercise Agreement has been 
duly authorized, executed and delivered by it, and is a valid and binding 
agreement of the undersigned, enforceable in accordance with its terms, 
except as enforceability may be limited by bankruptcy, insolvency, 
reorganization, moratorium or similar laws affecting creditors' rights 
generally or by equitable principles.

                                    A-2

<PAGE>

     (c)  INVESTMENT REPRESENTATIONS.

        (i)  It is acquiring the Shares for its own account, not as nominee 
or agent, for investment and not with a view to, or for resale in connection 
with, any distribution or public offering thereof within the meaning of the 
Securities Act, except as contemplated herein.  By executing this Warrant 
Exercise Agreement, it further represents that it does not have any contract, 
undertaking, agreement or arrangement with any person to sell, transfer or 
grant participation to such person or to any third person, with respect to 
any of the Shares.

        (ii) It understands that (i) the Shares have not been registered 
under the Securities Act by reason of a specific exemption therefrom, that 
such securities must be held by it indefinitely and that the undersigned 
must, therefore, bear the economic risk of such investment indefinitely, 
unless  a subsequent disposition thereof is registered under the Securities 
Act or is exempt from such registration; (ii) each certificate representing 
the Shares and the Shares will be endorsed with the following legends:

            (1)  THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE 
SECURITIES ACT OF 1933, AS AMENDED.  THEY MAY NOT BE SOLD, OFFERED FOR SALE, 
PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT 
AS TO THE SECURITIES UNDER SAID ACT OR AN OPINION OF COUNSEL REASONABLY 
SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED.

            (2)  Any legend required to be placed thereon under applicable 
state securities laws;

and (iii) the Company will instruct any transfer agent not to register the 
transfer of the Shares (or any portion thereof) unless the conditions 
specified in the foregoing legends are satisfied, until such time as a 
transfer is made, pursuant to the terms of this Agreement, and in compliance 
with Rule 144 or pursuant to a registration statement or, if the opinion of 
counsel referred to above is to the further effect that such legend is not 
required in order to establish compliance with any provisions of the 
Securities Act or this Agreement.

        (iii) It has been furnished with all information it considers 
necessary or appropriate for deciding whether to purchase the Shares.  It has 
been afforded the opportunity to ask questions and receive answers from the 
Company regarding the terms and conditions of the Offer to Amend and the 
exercise of its Warrant.

        (iv) It is an investor in securities of companies in the development 
stage and acknowledges that it can bear the economic risk of its investment 
and has such knowledge and experience in financial or business matters that 
it is capable of evaluating the merits and risks of the investment in the 
Shares.

        (v)  It is an "accredited investor" as such term is defined in Rule 
501 of the Securities Act of 1933, as amended, and it was not formed for the 
specific purpose of acquiring the Shares.

          (4)  INDEMNIFICATION.  The Investor acknowledges that it understands
     the meaning and legal consequences of the representations and warranties
     contained in Section 3 hereof, and the undersigned hereby agrees to
     indemnify and defend the Company and each director, officer, agent,
     employee, representative and stockholders thereof against and hold them
     harmless from any and all loss, damage or liability due to or arising out
     of a breach of any such representation or warranty.

                                  A-3

<PAGE>

     IN WITNESS WHEREOF, subject to the acceptance by the Company, the 
undersigned has completed this Warrant Exercise Agreement to evidence its 
acceptance of the Offer and the exercise of the Amended Warrant.
               

                                     -------------------------------------

                                     By: 
                                         ---------------------------------

                                     Name: 
                                           -------------------------------

                                     Title: 
                                            ------------------------------

                                     Dated: 
                                            ------------------------------

                                          

                                        A-4

<PAGE>

                                      EXHIBIT D
                                          
                            DESCRIPTION OF COMMON STOCK


     The Company is authorized to issue 50,000,000 shares of Common Stock, 
$.001 par value per share, and 10,000,000 shares of undesignated Preferred 
Stock, $.001 par value per share.

     As of May 31, 1998, there were 14,039,493 outstanding shares of the 
Company's Common Stock.  Holders of Common Stock are entitled to one vote for 
each share held of record on all matters submitted to a vote of stockholders. 
Subject to preferences that may be applicable to any outstanding shares of 
Preferred Stock, holders of Common Stock are entitled to receive ratably such 
dividends, if any, as may be declared by the Board of Directors out of funds 
legally available for the payment of dividends.  The Company has never paid 
any cash dividends on its Common Stock.  In the event of a liquidation, 
dissolution or winding up of the Company, holders of Common Stock are 
entitled to share ratably in all assets remaining after payment of 
liabilities and liquidation preferences of any outstanding shares of 
Preferred Stock.  Holders of Common Stock have no preemptive rights or rights 
to convert their Common Stock into any other securities.  There are no 
redemption or sinking fund provisions applicable to the Common Stock.  All 
outstanding shares of Common Stock are validly issued, fully paid and 
nonassessable.  All shares of Common Stock issuable upon conversion of the 
outstanding shares of Preferred Stock will be validly issued, fully paid and 
nonassessable upon such conversion.

     In September 1997 the Company's Board of Directors adopted a Stockholder 
Rights Plan and subsequently distributed one Preferred Stock purchase right 
(a "Right") for each outstanding share of the Company's Common Stock.  Each 
Right entitles the registered holder to purchase from the Company one 
one-hundredth of a share of the Company's Series C Junior Participating 
Preferred Stock, par value $.001 per share (the "Series C Junior Preferred 
Stock") at a purchase price of $50.00 per one one-hundredth of a share of 
Series C Junior Preferred Stock (subject to customary anti-dilution 
adjustments) (the "Purchase Price"). The Rights become exercisable if a 
person or group acquires, in a transaction not approved by the Company's 
Board of Directors, 20% or more of the Company's Common Stock or announces a 
tender offer for 20% or more of the Company's Common Stock.

     If the right becomes exercisable, each Right (other than Rights held by 
the acquiring person or group which become void) will entitle the holder to 
acquire, in lieu of purchasing Preferred Stock, upon exercise, a number of 
shares of Company Common Stock having a market value of two times the 
Purchase Price of the Right. If the Company is acquired in a transaction not 
approved by the Board of Directors, each Right may be exercised for common 
shares of the acquiring company having a market value of twice the Right's 
exercise price. The Company may redeem the Rights at $.001 per Right, subject 
to certain conditions. The Rights expire on September 18, 2007.


                                     D-1
<PAGE>

     The Series C Junior Preferred Stock is not redeemable by the Company.  
Each share of Series C Junior Preferred Stock is entitled to a minimum 
preferential quarterly dividend payment of $1.00 per share but is entitled to 
an aggregate dividend of 100 times the amount of any dividend declared per 
share on the Common Stock.  In the event of liquidation, the holders of the 
Series C Junior Preferred Stock will be entitled to a minimum preferential 
liquidation payment of $1.00 per share but will be entitled to an aggregate 
payment of 100 times the payment made per outstanding share of Common Stock.  
Each share of Series C Junior Preferred Stock will have 100 votes, voting 
together with the outstanding shares of Common Stock (and any other series or 
classes entitled to vote therewith) as a single class on all matters 
submitted for a stockholder vote. In the event of any merger, consolidation 
or other transaction in which shares of Common Stock are exchanged, each 
share of Series C Junior Preferred Stock will be entitled to receive 100 
times the amount received per outstanding share of Common Stock.  These 
rights are protected by customary anti-dilution provisions.  As of May 31, 
1998, no shares of Series C Junior Preferred Stock were issued and 
outstanding, although the Company had reserved for issuance 500,000 shares of 
its Series C Junior Preferred Stock.


                                        D-2

<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<RESTATED> 
<CIK> 0000882100
<NAME> CORVAS INTERNATIONAL, INC.
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          DEC-31-1998
<PERIOD-END>                               JUN-30-1998
<CASH>                                           3,541
<SECURITIES>                                    16,933
<RECEIVABLES>                                      411
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                21,239
<PP&E>                                           5,258
<DEPRECIATION>                                   3,596
<TOTAL-ASSETS>                                  22,901
<CURRENT-LIABILITIES>                            3,871
<BONDS>                                              0
                                0
                                          1
<COMMON>                                            14
<OTHER-SE>                                      19,015
<TOTAL-LIABILITY-AND-EQUITY>                    22,901
<SALES>                                             44
<TOTAL-REVENUES>                                 5,632
<CGS>                                               18
<TOTAL-COSTS>                                    9,966
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                   0
<INCOME-PRETAX>                                (3,757)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                            (3,757)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (3,757)
<EPS-PRIMARY>                                    (.27)
<EPS-DILUTED>                                    (.27)
        

</TABLE>


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