CORVAS INTERNATIONAL INC
SC 13G/A, 1999-02-16
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, D.C. 20549






                                  SCHEDULE 13G
                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*




                           Corvas International, Inc.
- -------------------------------------------------------------------------------
                                (Name of Issuer)


                          Common Stock, $.001 par value
- -------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    221005101
- -------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 1998
- -------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|  Rule 13d-1(b)
|X|  Rule 13d-1(c)
|_|  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>

CUSIP No. 221005101                       13G
          ---------

- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Four Partners
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)   |_|
                                                    (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             New York

- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             1,300,293
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          1,300,293
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- ------------ ------------------------------------------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      1,300,293

- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
             SHARES*
                                                                     |_|

- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      8.6%

- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      PN
- ------------ ------------------------------------------------------------------



<PAGE>

Item 1.

              (a)   Name of Issuer

                    Corvas International, Inc. (the "Issuer")

              (b)   Address of Issuer's Principal Executive Offices

                    3030 Science Park Road
                    San Diego, California 92121

Item 2.

              (a)   Name of Persons Filing

                    Four Partners ("FP")

              (b)   Address of Principal Business Office or, if none, Residence

                    Four Partners
                    c/o Thomas J. Tisch
                    667 Madison Avenue
                    New York, NY 10021

              (c)   Citizenship

                    New York

              (d)   Title of Class of Securities

                    Common Stock, $.001 par value (the "Shares")

              (e)   CUSIP Number

                    221005101

Item 3.       If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b)
              or (c), check whether the person filing is a:

              (a)   |_| Broker or Dealer registered under Section 15 of the Act,

              (b)   |_| Bank as defined in section 3(a)(6) of the Act,

              (c)   |_| Insurance company as defined in section 3(a)(19) of the
                    Act,

              (d)   |_| Investment company registered under section 8 of the
                    Investment Company Act of 1940,

              (e)   |_| Investment Adviser registered under section 203 of the
                    Investment Advisers Act of 1940,

              (f)   |_| An employee benefit plan, Pension Fund which is subject
                    to the provisions of the  Employee Retirement Income
                    Security Act of 1974 or Endowment Fund; see (section)
                    240.13d-1(b)(1)(ii)(F),

              (g)   |_| A parent holding company, in accordance with (section)
                    240.13d-1(b)(ii)(G) (Note:  See Item 7),

              (h)   |_| A savings associations as defined in Section 3(b) of the
                    Federal Deposit Insurance Act (12 U.S.C. 1813);

              (i)   |_| A church plan that is excluded from the definition of
                    an investment company under section 3(c)(14) of the
                    Investment Company Act of 1940 (15 U.S.C. 80a-3);


                                       3

<PAGE>


              (j)   |_| Group, in accordance with (section) 240.13d-1(b)(1)
                    (ii)(J).

              If this statement is filed pursuant to (section) 240.13d-1(c),
              check this box            |X|.

Item 4.       Ownership

              (a)   Amount Beneficially Owned

                    As of the date hereof, FP is the beneficial owner of
                    1,300,293 Shares.

              (b)   Percent of Class

                    FP is the record owner of 8.6% of the outstanding Shares.

              (c)   Number of shares as to which the person has:

                     (i)   Sole power to vote or to direct the vote

                           FP has directly the sole power to vote or direct the
                           vote of the 1,300,293 Shares owned by it.

                     (ii)  Shared power to vote or to direct the vote

                           By virtue of their status as managing trustees of the
                           trusts which are the general partners of FP, Andrew
                           H. Tisch, Daniel R. Tisch, James S. Tisch and Thomas
                           J. Tisch (the "Messrs. Tisch") may be deemed to have
                           indirectly shared power to vote or direct the vote of
                           the 1,300,293 Shares owned by FP.

                     (iii) Sole power to dispose or to direct the disposition of

                           FP has directly the sole power to dispose or direct
                           the disposition of the 1,300,293 Shares owned by it.

                     (iv)  Shared power to dispose or to direct the disposition
                           of

                           By virtue of their status as managing trustees of the
                           trusts which are the general partners of FP, the
                           Messrs. Tisch may be deemed to have indirectly shared
                           power to dispose or direct the disposition of the
                           1,300,293 Shares owned by FP.

Item 5.       Ownership of Five Percent or Less of a Class

              Not applicable.

Item 6.       Ownership of More than Five Percent on Behalf of Another Person

              Not applicable.

Item 7.       Identification and Classification of the Subsidiary Which Acquired
              the Security Being Reported on By the Parent Holding Company

              Not applicable.

Item 8.       Identification and Classification of Members of the Group

              Not applicable.



                                       4
<PAGE>



Item 9.       Notice of Dissolution of Group

              Not applicable.

Item 10.      Certification

                    By signing below I certify that, to the best of my knowledge
              and belief, the securities referred to above were not acquired and
              are not held for the purpose of or with the effect of changing or
              influencing the control of the issuer of such securities and were
              not acquired and are not held in connection with or as a
              participant in any transaction having that purpose or effect.


                                    SIGNATURE

              After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

Dated:   February 12, 1999

                                FOUR PARTNERS



                                By:  /s/ Thomas J. Tisch
                                    ----------------------------------
                                    Thomas J. Tisch
                                    Manager of Four Partners




                                       5


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