CORVAS INTERNATIONAL INC
SC 13D/A, 2000-11-15
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                 SCHEDULE 13D/A

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 2 )

                            CORVAS INTERNATIONAL INC.
                    -----------------------------------------
                                (NAME OF ISSUER)

                                  COMMON STOCK
                    -----------------------------------------
                         (TITLE OF CLASS OF SECURITIES)

                                   221 005 101
                    -----------------------------------------
                                 (CUSIP NUMBER)

         GINETTE DEPELTEAU, SOFINOV SOCIETE FINANCIERE D'INNOVATION INC.
   1981 MCGILL COLLEGE AVENUE, MONTREAL (QUEBEC), H3A 3C7 TEL.: (514) 847-5901
------------------------------------------------------------------------------
                  (NAME, ADDRESS AND TELEPHONE NUMBER OF PERSON
                AUTHORIZED TO RECEIVE NOTICES AND COMMUNICATIONS)

                                NOVEMBER 3, 2000
                    -----------------------------------------
                      (DATE OF EVENT WHICH REQUIRES FILING
                               OF THIS STATEMENT)


If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D/A, and is filing this
schedule because of Rule 13d-1 (b)(3) or (4), check the following box   / /.

Check the following box if a fee is being paid with the statement   / /.
(A fee is not required only if the reporting person: (1) has a previous
statement on file reporting beneficial ownership of more than five percent of
the class of securities described in Item 1; and (2) has filed no amendment
subsequent thereto reporting beneficial ownership of five percent or less of
such class.) (See Rule 13d-7.)

Note: Six copies of this statement, including all exhibits, should be filed with
the Commission. See Rule 13d-1(a) for other parties to whom copies are to be
sent.

* The remainder of this cover page shall be filed out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                        (Continued on following page(s))

                                      1
<PAGE>

CUSIP No. 221 005 101
===============================================================================
1.               NAME OF REPORTING PERSON
                 S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                 SOFINOV, SOCIETE FINANCIERE D'INNOVATION, INC.
===============================================================================
2.               CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                      (a) / /1
                                                                      (b) / /2
===============================================================================
3.               SEC USE ONLY

===============================================================================
4.               SOURCE OF FUNDS*: WC
===============================================================================
5.               CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                 PURSUANT TO ITEMS 2(d) OR 2(e)                           / / 3
===============================================================================
6.               CITIZENSHIP OR PLACE OF ORGANIZATION

                 MONTREAL, QUEBEC, CANADA
===============================================================================
NUMBER OF SHARES BENEFICIALLY     7.       SOLE VOTING POWER:
OWNED BY EACH REPORTING PERSON             950,000 COMMON SHARES
WITH
                                  =============================================
                                  8.       SHARED VOTING POWER:
                                           --
                                  =============================================
                                  9.       SOLE DISPOSITIVE POWER:
                                           950,000 COMMON SHARES
                                  =============================================
                                  10.      SHARED DISPOSITIVE POWER:
                                           --
===============================================================================
11.              AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                 950,000 COMMON SHARES
===============================================================================
12.              CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                 CERTAIN  SHARES                                         / / 4
===============================================================================
13.              PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):

                 4,49%
===============================================================================
14.              TYPE OF REPORTING PERSON: CO
===============================================================================
                     * SEE INSTRUCTIONS BEFORE FILLING OUT!

                                       2

<PAGE>

CUSIP No. 221 005 101
===============================================================================
1.               NAME OF REPORTING PERSON
                 S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                 CAISSE DE DEPOT ET PLACEMENT DU QUEBEC.
===============================================================================
2.               CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                     (a) / / 5
                                                                     (b) / / 6
===============================================================================
3.               SEC USE ONLY

===============================================================================
4.               SOURCE OF FUNDS*:  WC
===============================================================================
5.               CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                 PURSUANT TO ITEMS 2(d) OR 2(e)                          / / 7
===============================================================================
6.               CITIZENSHIP OR PLACE OF ORGANIZATION

                 MONTREAL, QUEBEC, CANADA
===============================================================================
NUMBER OF SHARES BENEFICIALLY     7.       SOLE VOTING POWER:
OWNED BY EACH REPORTING PERSON             950,000 COMMON SHARES
WITH
                                  =============================================
                                  8.       SHARED VOTING POWER:
                                           --
                                  =============================================
                                  9.       SOLE DISPOSITIVE POWER:
                                           950,000 COMMON SHARES
                                  =============================================
                                  10.      SHARED DISPOSITIVE POWER:
                                           --
===============================================================================
11.              AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                 950,000 COMMON SHARES
===============================================================================
12.              CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                 CERTAIN  SHARES                                         / / 8
===============================================================================
13.              PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):

                 4,49%
===============================================================================
14.              TYPE OF REPORTING PERSON: CO
===============================================================================

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!

                                           3

<PAGE>



                                 AMENDMENT NO. 2

                  This Amendment No. 2, dated November 3, 2000, to the statement
on Schedule 13D filed in hard copies with the Securities and Exchange Commission
(the "SEC") on November 3, 2000, is being filed jointly on behalf of Caisse de
depot et placement du Quebec ("CDPQ") and by its wholly-owned subsidiary,
SOFINOV, Societe financiere d'innovation, inc. ("Sofinov") pursuant to Rule
13d-2(a) under the Securities Exchange Act of 1934, as amended (the "Exchange
Act") pursuant to a Joint Filing Agreement dated November 3, 2000, between CDPQ
and Sofinov, a copy of which is attached hereto as Exhibit 1.


ITEM 1 - SECURITY AND ISSUER

                  This schedule 13D/A relates to the Common Stock of Corvas
International Inc., "Corvas", a California corporation (the "Company"). The
address of the principal executive offices of the Company is 3030 Science Park
Road, San Diego, California, 92121.

ITEM 2 - IDENTITY AND BACKGROUND

                  This Schedule 13D/A is filed jointly on behalf of CDPQ, a
corporation without share capital and an agent of the Crown in right of the
Province de Quebec, created by a special act of the Legislature of the Province
de Quebec, and Sofinov, a legal entity duly incorporated under part 1A of the
Companies ACT (Quebec) and a wholly-owned subsidiary of CDPQ, pursuant to Rule
13d-1(f)(1) under the Exchange Act.

                  The principal business address and the principal office
address of each of CDPQ and Sofinov is 1981, Avenue McGill College, Suite 1330,
Montreal, Quebec, H3A 3C7, Canada. The name, business address, citizenship and
present principal occupation of each director and executive officer of CDPQ and
Sofinov are set forth on Schedule I.

                  To the best knowledge of CDPQ and Sofinov, none of the persons
listed on Schedule I has, during the last five years, (i) been convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors) or
(ii) been a party to a civil proceeding of a judicial or administrative body of
competent jurisdiction and as a result of such proceeding was or is subject to a
judgment, decree or final order enjoining future violations of, or prohibiting
or mandating activities subject to, United States federal or state securities
laws or finding any violation with respect to such laws.



ITEM 3 - SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

                  All the funds required to purchase the Initial Shares were
obtained from the working capital of Sofinov.

Sofinov also sold 450,000 Shares for Can.$14,473,836.

                                       4

<PAGE>

ITEM 4 - PURPOSE OF TRANSACTION

The Shares reported on herein were acquired or sold for purposes of investment.

CDPQ and Sofinov intend to review on a continuing basis their investment in the
Company. As of the date of this Schedule 13D/A, no determination has been made
by CDPQ or Sofinov to acquire additional shares of Common Stock or dispose of
any shares of Common Stock now held by them, although either of them may decide
to so acquire or dispose of shares of Common Stock. Any such determination will
depend on market conditions prevailing from time to time and on other conditions
which may be applicable depending on the nature of the transaction or
transactions involved.

ITEM 5 - INTEREST IN SECURITIES OF ISSUER

                  (a) With recent transactions, Sofinov is now the direct
beneficial owner of 950,000 Shares of Common Stock (the "Sofinov Shares"). CDPQ
may be deemed to be the indirect, beneficial owner of the Sofinov Shares. The
Sofinov Shares represent approximately 4,49% of the 21,153,215 shares of Common
Stock of the Company outstanding on the date hereof, based upon information
provided by the company.

                  (b) CDPQ has the power to vote and dispose of the Sofinov
Shares.

                  (c) Except as set forth in this Schedule 13D/A, none of CDPQ,
Sofinov or, to the best knowledge of CDPQ or Sofinov, any person named on
Schedule I hereto, owns any shares of the Company's Common Stock, and none has
purchased or sold any shares of the Company's Common Stock during the past 60
days.

                  (d) Except as set forth in this Schedule 13D/A, no person is
known by CDPQ or Sofinov to have the right to receive or the power to direct the
receipt of dividends from, or the proceeds from the sale of, the shares of
Common Stock of the Company beneficially owned by CDPQ and Sofinov.

                  (e)      Not applicable.

ITEM 6 - CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH
         RESPECT TO SECURITIES OF THE ISSUER

                  Except as set forth in this Schedule 13D/A, there are no
contracts, arrangements, understandings or relationships (legal or otherwise)
among the persons referred to in Item 2 of this Schedule 13D/A or between such
persons and any other person with respect to any of the securities of the
Company, including, but not limited to, any relating to the transfer or voting
of any of such securities, finder's fees, joint ventures, loan or option
arrangements, puts or calls, guarantees of profits, division of profits or loss
or the giving or withholding of proxies.

ITEM 7 - MATERIAL TO BE FILED AS EXHIBITS

                                       5

<PAGE>

                  1. Joint Filing Agreement dated November 3, 2000 by
                     and between Sofinov and CDPQ.

                  2. Joint Filing Table of Purchase of Corvas
                     International Inc..

SIGNATURES

                  After reasonable inquiry and to the best knowledge and belief
of the undersigned, the undersigned certifies that the information set forth in
this statement is true, complete and correct.

Date: November 3, 2000


SOFINOV SOCIETE FINANCIERE D'INNOVATION INC.

By:_________________________________________
     Name:  Ginette Depelteau
     Title: Corporate Secretary


CAISSE DE DEPOT ET PLACEMENT DU QUEBEC.

By:__________________________________________
     Name:  Ginette Depelteau
     Title: General Secretary - Director

                                       6

<PAGE>

                                   SCHEDULE I

               LIST OF EXECUTIVE OFFICERS AND DIRECTORS OF SOFINOV
<TABLE>
<CAPTION>
DIRECTORS                      BUSINESS ADDRESS                                             PRINCIPAL OCCUPATION
<S>                            <C>                                                          <C>
Jean-Claude Scraire            Caisse de depot et placement du Quebec                       Chairman
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Line Boisvert                  Caisse de depot et placement du Quebec                       Director and
                               1981, Avenue McGill College                                  Portfolio Manager
                               Montreal (Quebec) H3A 3C7

Jacques M. Brault              Levesque Beaubien Geoffrion Inc.                             Senior
                               1155, Metcalfe, 5e etage                                     Vice-President
                               Montreal, (Qubec) H3B 4S9

Denis Dionne                   SOFINOV, Societe financiere d'innovation, inc.               President
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Claude Lajeunesse              Ryerson Polytechnic University                               President and Vice
                               350, Victoria Street                                         Chancellor
                               Toronto (Ontario) H2M 2V1

Serge Martin                   Martin International                                         President
                               500, Place d'Armes, Suite 2910
                               Montreal, (Qubec) H2Y 2W2

Guy Morneau                    Regie des rentes du Quebec                                   Chairman of the
                               2600 boul. Laurieir, bureau 546                              Board and President
                               Qubec (Qubec) G1V 4T3

Normand Provost                Caisse de depot et placement du Quebec                       Vice-President
                               1981, Avenue McGill College                                  Coordinator
                               Montreal (Quebec) H3A 3C7
</TABLE>

                                       7

<PAGE>

                                   SCHEDULE 1

               LIST OF EXECUTIVE OFFICERS AND DIRECTORS OF SOFINOV
<TABLE>
<CAPTION>

OFFICERS                       BUSINESS ADDRESS                                             PRINCIPAL OCCUPATION
<S>                            <C>                                                          <C>
Jean-Claude Scraire            Caisse de depot et placement du Quebec                       Chairman
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Denis Dionne                   SOFINOV, Societe financiere d'innovation, inc.               President
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Pierre Pharand                 SOFINOV, Societe financiere d'innovation, inc.               Vice-President
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7

Bertrand Lauzon                Caisse de depot et placement du Quebec                       Vice-President,
                               1981, Avenue McGill College                                  Finance and Control
                               Montreal (Quebec) H3A 3C7

Ginette Depelteau              Caisse de depot et placement du Quebec                       Secretary
                               1981, Avenue McGill College
                               Montreal (Quebec) H3A 3C7
</TABLE>

                                           8

<PAGE>

                                   SCHEDULE 1

                LIST OF EXECUTIVE OFFICERS AND DIRECTORS OF CDPQ
<TABLE>
<CAPTION>
DIRECTORS                      BUSINESS ADDRESS                                      PRINCIPAL OCCUPATION
<S>                            <C>                                                   <C>
Jean-Claude Scraire            Caisse de depot et placement du Quebec                Chairman
                               1981, avenue McGill College
                               Montreal (Quebec) H3A 3C7

Guy Morneau                    Regie des rentes du Quebec                            Chairman of the Board
                               2600, boul. Laurier, bureau 546                       and President
                               Quebec (Quebec)  G1V 4T3

Jean-Claude Bachand            Byers Casgrain                                        Lawyer
                               1, Place Ville-Marie
                               Bureau 3900
                               Montreal (Quebec) H3B 4M7

Claude Beland                  La Confederation des Caisses populaires et            President
                               d'economie Desjardins du Quebec
                               100, avenue des Commandeurs
                               Levis (Quebec) G6V 7N5

Luc Bessette                   Commission administrative des regimes                 President
                               de retraite et d'assurances
                               475, rue Saint-Amable
                               Quebec (Quebec)  G1R 5X3

Rodrigue Biron                 Rodrigue Biron & Associes
                               305, chemin de la Place St-Laurent
                               St-Augustin-de-Desmaures
                               Cap-Rouge (Quebec)  G1Y 3G9

Yves Filion                    Hydro-Quebec                                          Deputy Chief
                               75, boul. Rene-Levesque Ouest                         Executive Officer
                               Montreal (Quebec)                                     and Chief Financial
                               H2Z 1A4                                               Officer

Jean-Yves Gagnon               Societe de l'assurance automobile du Quebec           General Manager
                               333, boul. Jean-Lesage
                               Quebec (Quebec)  G1K 8J6
</TABLE>

                                       9

<PAGE>

<TABLE>
<CAPTION>
DIRECTORS                      BUSINESS ADDRESS                                      PRINCIPAL OCCUPATION
<S>                            <C>                                                   <C>
Henri Masse                    Federation des travailleurs et travailleuses du       President
                               Quebec
                               545, boul. Cremazie Est, 17e etage
                               Montreal, (Quebec) H2M 2V1

Gilles Godbout                 Ministere des Finances                                Deputy Minister
                               12, rue St-Louis
                               Quebec (Quebec) G1R 5L3

Thomas O. Hecht                Technologies IBEX Inc.                                Chairman Emeritus
                               5485, rue Pare
                               Montreal (Quebec)  H4P 1P7

Gerald Larose                  Confederation des syndicats nationaux
                               1601, rue Delorimier
                               Montreal (Quebec) H2K 4M5

Nicole Trudeau                 Commission municipale du Quebec                       Vice-President
                               2, Complexe Desjardins
                               Suite 3100, East Tower
                               Montreal (Quebec) H5B 1B2
</TABLE>

                                       10


<PAGE>

                                   SCHEDULE 1

                LIST OF EXECUTIVE OFFICERS AND DIRECTORS OF CDPQ
<TABLE>
<CAPTION>
OFFICERS                       BUSINESS ADDRESS                                 PRINCIPAL OCCUPATION
<S>                            <C>                                              <C>
Jean-Claude Scraire            Caisse de depot et placement du Quebec           Chairman
                               1981, avenue McGill College
                               Montreal (Quebec) H3A 3C7

Fernand Perreault              Same                                             Senior Vice-president
                                                                                Caisse Real Estate Group
                                                                                and Mortgage Investments

Michel Nadeau                  Same                                             Senior Vice-president
                                                                                Investment Planning and
                                                                                Strategic Affairs

Ginette Depelteau              Same                                             General  Secretary -
                                                                                Director
</TABLE>

                                       11

<PAGE>

                                  EXHIBIT INDEX



EXHIBIT

1.       Joint Filing Agreement dated November 3, 2000 by and between
         Sofinov and CDPQ.

2.       Joint Filing Table of Purchases of Corvas International Inc..

                                       12

<PAGE>


                                    EXHIBIT 1


                                    AGREEMENT


                  The undersigned hereby agree that this statement on Schedule
13D/A with respect to beneficial ownership of shares of common stock of Corvas
International inc. is filed jointly, on behalf of each of them.


Dated:   November 3, 2000

SOFINOV, SOCIETE FINANCIERE D'INNOVATION, INC.


By:____________________________________________
      Name:      Denis Dionne
      Title:     President


By:_____________________________________________
     Name:       Ginette Depelteau
     Title:      Corporate Secretary



CAISSE DE DEPOT ET PLACEMENT DU QUEBEC.


By:_____________________________________________
     Name:       Michel Nadeau
     Title:      Senior Vice-president
                 Investment Planning and Strategic Affairs


By:______________________________________________
     Name:       Ginette Depelteau
     Title:      General Secretary - Director

                                       13

<PAGE>

                                    EXHIBIT 2



------------------------------------------------------------------------
                                TABLE OF SALES OF
                        CORVAS INTERNATIONAL INC. SHARES
------------------------------------------------------------------------


                             SALES OF COMMON SHARES
-------------------------------------------------------------------------
<TABLE>
<CAPTION>
                                                                              PRICE PER SHARE
DATE                                    NUMBER OF SHARES                      IN U.S. DOLLARS
----                                    ----------------                      ---------------
<S>                                     <C>                                   <C>
OCTOBER 27, 2000                               16,000                             $23.08
----------------
November 2, 2000                               50,000                             $22.68
NOVEMBER 3, 2000                              384,000                             $24.57
----------------
</TABLE>

                                                14




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