PROTEIN DESIGN LABS INC/DE
S-3, EX-1.1, 2000-08-29
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                                                     EXHIBIT 1.1

                               [NUMBER OF SHARES]

                            PROTEIN DESIGN LABS, INC.

                                  COMMON STOCK

                             UNDERWRITING AGREEMENT

                                  [Insert date]



CREDIT SUISSE FIRST BOSTON CORPORATION

-----------------------------------
-----------------------------------,

      As Representatives of the Several Underwriters,
           c/o Credit Suisse First Boston Corporation,
                Eleven Madison Avenue,
                     New York, N.Y. 10010-3629

Dear Sirs:

        1. Introductory. Protein Design Labs, Inc., a Delaware corporation
("COMPANY"), proposes to issue and sell ____________shares ("FIRM SECURITIES")
of its Common Stock ("SECURITIES") and also proposes to issue and sell to the
Underwriters, at the option of the Underwriters, an aggregate of not more than
____________ additional shares ("OPTIONAL SECURITIES") of its Securities as set
forth below. The Firm Securities and the Optional Securities are herein
collectively called the "OFFERED Securities". The Company hereby agrees with the
several Underwriters named in Schedule A hereto ("UNDERWRITERS") as follows:

        2. Representations and Warranties of the Company. The Company represents
and warrants to, and agrees with, the several Underwriters that:

             (a) A registration statement (No. 333-_______) relating to the
        Offered Securities, including a form of prospectus, has been filed with
        the Securities and Exchange Commission ("COMMISSION") and either (i) has
        been declared effective under the Securities Act of 1933 ("ACT") and is
        not proposed to be amended or (ii) is proposed to be amended by
        amendment or post-effective amendment. If such registration statement
        ("INITIAL REGISTRATION STATEMENt") has been declared effective, either
        (i) an additional registration statement ("ADDITIONAL REGISTRATION
        STATEMENT") relating to the Offered Securities may have been filed with
        the Commission pursuant to Rule 462(b) ("RULE 462(b)") under the Act
        and, if so filed, has become effective upon filing pursuant to such Rule
        and the Offered Securities all have been duly registered under the Act
        pursuant to the initial registration statement and, if applicable, the
        additional registration statement or (ii) such an additional
        registration statement is proposed to be filed with the Commission
        pursuant to Rule 462(b) and will become effective upon filing pursuant
        to



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        such Rule and upon such filing the Offered Securities will all have been
        duly registered under the Act pursuant to the initial registration
        statement and such additional registration statement. If the Company
        does not propose to amend the initial registration statement or if an
        additional registration statement has been filed and the Company does
        not propose to amend it, and if any post-effective amendment to either
        such registration statement has been filed with the Commission prior to
        the execution and delivery of this Agreement, the most recent amendment
        (if any) to each such registration statement has been declared effective
        by the Commission or has become effective upon filing pursuant to Rule
        462(c) ("RULE 462(c)") under the Act or, in the case of the additional
        registration statement, Rule 462(b). For purposes of this Agreement,
        "EFFECTIVE TIME" with respect to the initial registration statement or,
        if filed prior to the execution and delivery of this Agreement, the
        additional registration statement means (i) if the Company has advised
        the Representatives that it does not propose to amend such registration
        statement, the date and time as of which such registration statement, or
        the most recent post-effective amendment thereto (if any) filed prior to
        the execution and delivery of this Agreement, was declared effective by
        the Commission or has become effective upon filing pursuant to Rule
        462(c), or (ii) if the Company has advised the Representatives that it
        proposes to file an amendment or post-effective amendment to such
        registration statement, the date and time as of which such registration
        statement, as amended by such amendment or post-effective amendment, as
        the case may be, is declared effective by the Commission. If an
        additional registration statement has not been filed prior to the
        execution and delivery of this Agreement but the Company has advised the
        Representatives that it proposes to file one, "EFFECTIVE TIME" with
        respect to such additional registration statement means the date and
        time as of which such registration statement is filed and becomes
        effective pursuant to Rule 462(b). "EFFECTIVE DATE" with respect to the
        initial registration statement or the additional registration statement
        (if any) means the date of the Effective Time thereof. The initial
        registration statement, as amended at its Effective Time, including all
        material incorporated by reference therein, including all information
        contained in the additional registration statement (if any) and deemed
        to be a part of the initial registration statement as of the Effective
        Time of the additional registration statement pursuant to the General
        Instructions of the Form on which it is filed and including all
        information (if any) deemed to be a part of the initial registration
        statement as of its Effective Time pursuant to Rule 430A(b) ("RULE
        430A(b)") under the Act, is hereinafter referred to as the "INITIAL
        REGISTRATION STATEMENT". The additional registration statement, as
        amended at its Effective Time, including the contents of the initial
        registration statement incorporated by reference therein and including
        all information (if any) deemed to be a part of the additional
        registration statement as of its Effective Time pursuant to Rule
        430A(b), is hereinafter referred to as the "ADDITIONAL REGISTRATION
        STATEMENT". The Initial Registration Statement and the Additional
        Registration Statement are herein referred to collectively as the
        "REGISTRATION STATEMENTS" and individually as a "REGISTRATION
        STATEMENT". The form of prospectus relating to the Offered Securities,
        as first filed with the Commission pursuant to and in accordance with
        Rule 424(b) ("RULE 424(b)") under the Act or (if no such filing is
        required) as included in a Registration Statement, including all
        material incorporated by



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        reference in such prospectus, is hereinafter referred to as the
        "PROSPECTUS". No document has been or will be prepared or distributed in
        reliance on Rule 434 under the Act.

             (b) If the Effective Time of the Initial Registration Statement is
        prior to the execution and delivery of this Agreement: (i) on the
        Effective Date of the Initial Registration Statement, the Initial
        Registration Statement conformed in all respects to the requirements of
        the Act, and the rules and regulations of the Commission ("RULES AND
        REGULATIONS") and did not include any untrue statement of a material
        fact or omit to state any material fact required to be stated therein or
        necessary to make the statements therein not misleading, (ii) on the
        Effective Date of the Additional Registration Statement (if any), each
        Registration Statement conformed, or will conform, in all respects to
        the requirements of the Act, and the Rules and Regulations and did not
        include, or will not include, any untrue statement of a material fact
        and did not omit, or will not omit, to state any material fact required
        to be stated therein or necessary to make the statements therein not
        misleading and (iii) on the date of this Agreement, the Initial
        Registration Statement and, if the Effective Time of the Additional
        Registration Statement is prior to the execution and delivery of this
        Agreement, the Additional Registration Statement each conforms, and at
        the time of filing of the Prospectus pursuant to Rule 424(b) or (if no
        such filing is required) at the Effective Date of the Additional
        Registration Statement in which the Prospectus is included, each
        Registration Statement and the Prospectus will conform, in all respects
        to the requirements of the Act and the Rules and Regulations, and
        neither of such documents includes, or will include, any untrue
        statement of a material fact or omits, or will omit, to state any
        material fact required to be stated therein or necessary to make the
        statements therein not misleading. If the Effective Time of the Initial
        Registration Statement is subsequent to the execution and delivery of
        this Agreement: on the Effective Date of the Initial Registration
        Statement, the Initial Registration Statement and the Prospectus will
        conform in all respects to the requirements of the Act and the Rules and
        Regulations, neither of such documents will include any untrue statement
        of a material fact or will omit to state any material fact required to
        be stated therein or necessary to make the statements therein not
        misleading, and no Additional Registration Statement has been or will be
        filed. The two preceding sentences do not apply to statements in or
        omissions from a Registration Statement or the Prospectus based upon
        written information furnished to the Company by any Underwriter through
        the Representatives specifically for use therein, it being understood
        and agreed that the only such information is that described as such in
        Section 7(b) hereof.

             (c) The Company has been duly incorporated and is an existing
        corporation in good standing under the laws of the State of Delaware,
        with power and authority (corporate and other) to own its properties and
        conduct its business as presently conducted and as described in the
        Prospectus; and the Company is duly qualified to do business as a
        foreign corporation in good standing in all other jurisdictions in which
        its ownership or lease of property or the conduct of its business
        requires such qualification.

             (d) Each subsidiary of the Company has been duly incorporated and
        is an existing corporation in good standing under the laws of the
        jurisdiction of its


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        incorporation, with power and authority (corporate and other) to own its
        properties and conduct its business as described in the Prospectus; and
        each subsidiary of the Company is duly qualified to do business as a
        foreign corporation in good standing in all other jurisdictions in which
        its ownership or lease of property or the conduct of its business
        requires such qualification; all of the issued and outstanding capital
        stock of each subsidiary of the Company has been duly authorized and
        validly issued and is fully paid and nonassessable; and the capital
        stock of each subsidiary owned by the Company, directly or through
        subsidiaries, is owned free from liens, encumbrances and defects.

             (e) The Offered Securities and all other outstanding shares of
        capital stock of the Company have been duly authorized; all outstanding
        shares of capital stock of the Company are, and, when the Offered
        Securities have been delivered and paid for in accordance with this
        Agreement on each Closing Date (as defined below), such Offered
        Securities will have been, validly issued, fully paid and nonassessable
        and will conform to the description thereof contained in the Prospectus;
        and the stockholders of the Company and other third parties have no
        preemptive rights with respect to the Securities.

             (f) The authorized, issued and outstanding capital stock of the
        Company is as set forth in the Prospectus under the heading "Actual"
        under the caption "Capitalization," and after giving effect to the
        offering will be as set forth under the heading "As Adjusted", in each
        case under the caption "Capitalization" (except for subsequent
        issuances, if any, pursuant to this Agreement, pursuant to reservations,
        agreements or employee benefit plans referred to in the Prospectus or
        pursuant to the exercise of convertible securities or options referred
        to in the Prospectus) and the number of authorized, issued and
        outstanding options and other rights is set forth in the footnotes under
        such caption. The shares of issued and outstanding capital stock of the
        Company have been issued in compliance, in all material respects, with
        all federal and state securities laws. Except as disclosed in the
        Prospectus, there are no outstanding options to purchase, or any
        preemptive rights or other rights to subscribe for or to purchase, any
        securities or obligations convertible into, or any contracts or
        commitments to issue or sell, shares of the Company's capital stock or
        any such options, rights, convertible securities or obligations. The
        description of the Company's stock option and purchase plans and the
        options or other rights granted and exercised thereunder set forth in
        the Prospectus accurately and fairly describe, in all material respects,
        the information required to be shown with respect to such plans,
        arrangements, options and rights.

             (g) Except as disclosed in the Prospectus, there are no contracts,
        agreements or understandings between the Company and any person that
        would give rise to a valid claim against the Company or any Underwriter
        for a brokerage commission, finder's fee or other like payment in
        connection with this offering.

             (h) There are no contracts, agreements or understandings between
        the Company and any person granting such person the right to require the
        Company to file a registration statement under the Act with respect to
        any securities of the Company owned or to be owned by such person or to
        require the Company to include such securities in the



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        securities registered pursuant to a Registration Statement or in any
        securities being registered pursuant to any other registration statement
        filed by the Company under the Act.

             (i) The Offered Securities have been approved for listing on The
        Nasdaq Stock Market's National Market.

             (j) No consent, approval, authorization, or order of, or filing
        with, any governmental agency or body or any court is required for the
        consummation of the transactions contemplated by this Agreement in
        connection with the issuance and sale of the Offered Securities by the
        Company, except such as have been obtained and made under the Act and
        such as may be required under state securities laws.

             (k) The execution, delivery and performance of this Agreement, and
        the issuance and sale of the Offered Securities will not result in a
        breach or violation of any of the terms and provisions of, or constitute
        a default under, any statute, any rule, regulation or order of any
        governmental agency or body or any court, domestic or foreign, having
        jurisdiction over the Company or any subsidiary of the Company or any of
        their properties, or any agreement or instrument to which the Company or
        any such subsidiary is a party or by which the Company or any such
        subsidiary is bound or to which any of the properties of the Company or
        any such subsidiary is subject, or the charter or by-laws of the Company
        or any such subsidiary, and the Company has full power and authority to
        authorize, issue and sell the Offered Securities as contemplated by this
        Agreement.

             (l) Each agreement other than the Listed Agreements (as hereinafter
        defined) described in the Prospectus or filed as an exhibit to the
        Registration Statement (such agreements other than the Listed
        Agreements, collectively, the "IN-FORCE AGREEMENTS") is in full force
        and effect and is valid and enforceable by the Company or one of its
        subsidiaries, as applicable, in accordance with its terms, assuming the
        due authorization, execution and delivery thereof by each of the other
        parties thereto except as (i) the enforceability thereof may be limited
        by bankruptcy, insolvency or similar laws affecting creditors' rights
        generally and (ii) to the extent that rights to indemnity or
        contribution thereunder may be limited by federal and state securities
        laws or the public policy underlying such laws. None of the Company, any
        of its subsidiaries, or to the Company's knowledge, any other party is
        in default in the observance or performance of any term or obligation to
        be performed by it under any In-Force Agreement, and no event has
        occurred that with notice or lapse of time or both would constitute such
        a default, in any such case where such default or event would have
        Material Adverse Effect. No default exists, and no event has occurred
        that with notice or lapse of time or both would constitute a default, in
        the due performance and observance of any term, covenant or condition,
        by the Company or any of its subsidiaries of any other agreement or
        instrument to which the Company or any of its subsidiaries is a party or
        by which any of them or their respective properties or business may be
        bound or affected where such default or event would have a Material
        Adverse Effect. [For purposes of this Section



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        [____], "LISTED AGREEMENTS" shall mean [[(i) the License Agreement
        between the Company and Hoffmann-La Roche Inc., effective January 31,
        1989, and the letter dated November 4, 1992 amending such agreement,
        (ii) the License Agreement between the Company and F. Hoffmann-La Roche
        & Co., effective January 31, 1989, (iii) the Agreement between the
        Company and Kanebo, Ltd., dated February 29, 1992, (iv) the Asset
        Purchase and License Agreement among the Company, Sandoz Pharma Ltd. and
        Sandoz Pharmaceuticals Corporation, dated April 13, 1993, and the letter
        dated October 21, 1993 amending such agreement, (v) the License
        Agreement among the Company, Sandoz Pharma Ltd. and Sandoz Ltd., dated
        April 13, 1993, (vi) the Joint Development, Marketing and License
        Agreement between the Company and Corange International Limited, dated
        October 28, 1993, as amended, and (vii) the Industrial Lease Agreement
        between the Company and Ardenstone LLC, effective as of July 1, 1997.]]

             (m) This Agreement has been duly authorized, executed and delivered
        by the Company.

             (n) Except as disclosed in the Prospectus, the Company and its
        subsidiaries have good and marketable title to all real properties and
        all other properties and assets owned by them, in each case free from
        liens, encumbrances and defects that would materially affect the value
        thereof or materially interfere with the use made or to be made thereof
        by them; and except as disclosed in the Prospectus, the Company and its
        subsidiaries hold any leased real or personal property under valid and
        enforceable leases with no exceptions that would materially interfere
        with the use made or to be made thereof by them.

             (o) The Company and its subsidiaries possess adequate certificates,
        authorities or permits issued by appropriate governmental agencies or
        bodies necessary to conduct the business now operated by them and have
        not received any notice of proceedings relating to the revocation or
        modification of any such certificate, authority or permit that, if
        determined adversely to the Company or any of its subsidiaries, would
        individually or in the aggregate have a material adverse effect on the
        condition (financial or other), business, properties or results of
        operations of the Company and its subsidiaries taken as a whole
        ("MATERIAL ADVERSE EFFECT").

             (p) No labor dispute with the employees of the Company or any
        subsidiary exists or, to the knowledge of the Company, is imminent that
        might have a Material Adverse Effect.

             (q) The Company and its subsidiaries own, possess or can acquire on
        reasonable terms, adequate trademarks, trade names and other rights to
        inventions, know-how, patents, copyrights, confidential information and
        other intellectual property (collectively, "INTELLECTUAL PROPERTY
        RIGHTS") necessary to conduct the business now operated by them or
        proposed to be operated by them as described in the Prospectus,
        presently employed by them, or as described or contemplated in the
        Prospectus and have not received any notice of infringement of or
        conflict with asserted rights of others with



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        respect to any intellectual property rights that, if determined
        adversely to the Company or any of its subsidiaries, would individually
        or in the aggregate have a Material Adverse Effect.

             (r) Except as disclosed in the Prospectus, neither the Company nor
        any of its subsidiaries is in violation of any statute, any rule,
        regulation, decision or order of any governmental agency or body or any
        court, domestic or foreign, relating to the use, disposal or release of
        hazardous or toxic substances or relating to the protection or
        restoration of the environment or human exposure to hazardous or toxic
        substances (collectively, "ENVIRONMENTAL LAWS"), owns or operates any
        real property contaminated with any substance that is subject to any
        environmental laws, is liable for any off-site disposal or contamination
        pursuant to any environmental laws, or is subject to any claim relating
        to any environmental laws, which violation, contamination, liability or
        claim would individually or in the aggregate have a Material Adverse
        Effect; and the Company is not aware of any pending investigation which
        might lead to such a claim.

             (s) Except as disclosed in the Prospectus, there are no pending
        actions, suits or proceedings against or affecting the Company, any of
        its subsidiaries or any of their respective properties that, if
        determined adversely to the Company or any of its subsidiaries, would
        individually or in the aggregate have a Material Adverse Effect, or
        would materially and adversely affect the ability of the Company to
        perform its obligations under this Agreement, or which are otherwise
        material in the context of the sale of the Offered Securities; and no
        such actions, suits or proceedings are threatened or, to the Company's
        knowledge, contemplated.

             (t) The financial statements included in each Registration
        Statement and the Prospectus present fairly the financial position of
        the Company and its consolidated subsidiaries as of the dates shown and
        their results of operations and cash flows for the periods shown, and,
        except as otherwise disclosed in the Prospectus, such financial
        statements have been prepared in conformity with the generally accepted
        accounting principles in the United States applied on a consistent basis
        and the schedules included in each Registration Statement present fairly
        the information required to be stated therein; and the assumptions used
        in preparing the pro forma financial statements included in each
        Registration Statement and the Prospectus provide a reasonable basis for
        presenting the significant effects directly attributable to the
        transactions or events described therein, the related pro forma
        adjustments give appropriate effect to those assumptions, and the pro
        forma columns therein reflect the proper application of those
        adjustments to the corresponding historical financial statement amounts.

             (u) Except as disclosed in the Prospectus, since the date of the
        latest audited financial statements included in the Prospectus there has
        been no material adverse change, nor any development or event involving
        a prospective material adverse change, in the condition (financial or
        other), business, properties or results of operations of the Company and
        its subsidiaries taken as a whole, and, except as disclosed in or



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        contemplated by the Prospectus, there has been no dividend or
        distribution of any kind declared, paid or made by the Company on any
        class of its capital stock.

             (v) The Company is not and, after giving effect to the offering and
        sale of the Offered Securities and the application of the proceeds
        thereof as described in the Prospectus, will not be an "investment
        company" as defined in the Investment Company Act of 1940.

             (w) All material tax returns required to be filed by the Company
        and each of its subsidiaries in any jurisdiction have been filed, other
        than those filings being contested in good faith, and all material
        taxes, including withholding taxes, penalties and interest, assessments,
        fees and other charges due pursuant to such returns or pursuant to any
        assessment received by the Company or any of its subsidiaries have been
        paid, other than those being contested in good faith and for which
        adequate reserves have been established on the books and records of the
        Company in accordance with GAAP. To the Company's knowledge, there are
        no proposed, material Tax assessments against the Company. To the
        Company's knowledge, the accruals and reserves on the books and records
        of the Company in respect of any material Tax liability for any Taxable
        period not finally determined are adequate to meet any assessments of
        Tax for any such period. For purposes of this Agreement, the terms "TAX"
        and "TAXES" shall mean all Federal, state, local, and foreign taxes, and
        other assessments of a similar nature (whether imposed directly or
        through withholding), including any interest, additions to tax, or
        penalties applicable thereto.

             (x) The Company has not taken, nor will it take, directly or
        indirectly, any action designed to or that might reasonably be expected
        to cause or result in, or that has constituted or that might reasonably
        be expect to constitute, the stabilization or manipulation of the price
        of the Common Stock.

             (y) To the knowledge of the Company, Ernst & Young LLP, who have
        certified the financial statements filed with the Commission as part of
        each Registration Statement, are independent public auditors as required
        by the Act and the Rules and Regulations. The Company maintains a system
        of internal accounting controls sufficient to provide reasonable
        assurances that (A) transactions are executed in accordance with
        management's general or specific authorization; (B) transactions are
        recorded as necessary to permit preparation of financial statements in
        conformity with GAAP and to maintain accountability for assets; and (C)
        access to assets is permitted only in accordance with management's
        general or specific authorization.

             (z) The Company carries, or is covered by, insurance in such
        amounts and covering such risks as is adequate for the conduct of its
        businesses and the value of its properties and as is customary for
        companies engaged in similar industries.

        3. Purchase, Sale and Delivery of Offered Securities. On the basis of
the representations, warranties and agreements herein contained, but subject to
the terms and conditions herein set forth, the Company agrees to sell to the
Underwriters, and the Underwriters



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agree, severally and not jointly, to purchase from the Company, at a purchase
price of $____ per share, the respective number of shares of Firm Securities set
forth opposite the names of the Underwriters in Schedule A hereto.

        The Company will deliver the Firm Securities to the Representatives for
the accounts of the Underwriters, at the office of Skadden, Arps, Slate, Meagher
& Flom LLP, 525 University Avenue, Suite 220, Palo Alto, California, against
payment of the purchase price in Federal (same day) funds by official bank check
or checks or wire transfer to an account at a bank acceptable to Credit Suisse
First Boston Corporation ("CSFBC") drawn to the order of __________________ at
the office of Skadden, Arps, Slate, Meagher & Flom LLP, at _______ A.M., New
York time, on ____________________________, or at such other time not later than
seven (7) full business days thereafter as CSFBC and the Company determine, such
time being herein referred to as the "FIRST CLOSING DATE". For purposes of Rule
15c6-1 under the Securities Exchange Act of 1934, the First Closing Date (if
later than the otherwise applicable settlement date) shall be the settlement
date for payment of funds and delivery of securities for all the Offered
Securities sold pursuant to the offering. The certificates for the Firm
Securities so to be delivered will be in definitive form, in such denominations
and registered in such names as CSFBC requests and will be made available for
checking and packaging at the above office of Skadden, Arps, Slate, Meagher &
Flom LLP at least 24 hours prior to the First Closing Date.

        In addition, upon written notice from CSFBC given to the Company from
time to time not more than thirty (30) days subsequent to the date of the
Prospectus, the Underwriters may purchase all or less than all of the Optional
Securities at the purchase price per Security to be paid for the Firm
Securities. The Company agrees to sell to the Underwriters the number of shares
of Optional Securities specified in such notice and the Underwriters agree,
severally and not jointly, to purchase such Optional Securities. Such Optional
Securities shall be purchased for the account of each Underwriter in the same
proportion as the number of shares of Firm Securities set forth opposite such
Underwriter's name bears to the total number of shares of Firm Securities
(subject to adjustment by CSFBC to eliminate fractions) and may be purchased by
the Underwriters only for the purpose of covering over-allotments made in
connection with the sale of the Firm Securities. No Optional Securities shall be
sold or delivered unless the Firm Securities previously have been, or
simultaneously are, sold and delivered. The right to purchase the Optional
Securities or any portion thereof may be exercised from time to time and to the
extent not previously exercised may be surrendered and terminated at any time
upon notice by CSFBC to the Company.

        Each time for the delivery of and payment for the Optional Securities,
being herein referred to as an "OPTIONAL CLOSING DATE", which may be the First
Closing Date (the First Closing Date and each Optional Closing Date, if any,
being sometimes referred to as a "CLOSING DATE"), shall be determined by CSFBC
but shall be not later than five (5) full business days after written notice of
election to purchase Optional Securities is given. The Company will deliver the
Optional Securities being purchased on each Optional Closing Date to the
Representatives for the accounts of the several Underwriters, at the office of
Skadden, Arps, Slate, Meagher & Flom LLP, 525 University Avenue, Suite 220, Palo
Alto, California, against payment of the purchase price therefor in Federal
(same day) funds by official bank check or checks or wire



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transfer to an account at a bank acceptable to CSFBC drawn to the order of
________________, at the above office of Skadden, Arps, Slate, Meagher & Flom
LLP. The certificates for the Optional Securities being purchased on each
Optional Closing Date will be in definitive form, in such denominations and
registered in such names as CSFBC requests upon reasonable notice prior to such
Optional Closing Date and will be made available for checking and packaging at
the above office of Skadden, Arps, Slate, Meagher & Flom LLP at a reasonable
time in advance of such Optional Closing Date.

        4. Offering by Underwriters. It is understood that the several
Underwriters propose to offer the Offered Securities for sale to the public as
set forth in the Prospectus.

        5. Certain Agreements of the Company. The Company agrees with the
several Underwriters that:

             (a) If the Effective Time of the Initial Registration Statement is
        prior to the execution and delivery of this Agreement, the Company will
        file the Prospectus with the Commission pursuant to and in accordance
        with subparagraph (1) (or, if applicable and if consented to by CSFBC,
        subparagraph (4)) of Rule 424(b)) not later than the earlier of (A) the
        second business day following the execution and delivery of this
        Agreement or (B) the fifteenth business day after the Effective Date of
        the Initial Registration Statement.

             The Company will advise CSFBC promptly of any such filing pursuant
        to Rule 424(b). If the Effective Time of the Initial Registration
        Statement is prior to the execution and delivery of this Agreement and
        an additional registration statement is necessary to register a portion
        of the Offered Securities under the Act but the Effective Time thereof
        has not occurred as of such execution and delivery, the Company will
        file the additional registration statement or, if filed, will file a
        post-effective amendment thereto with the Commission pursuant to and in
        accordance with Rule 462(b) on or prior to 10:00 P.M., New York time, on
        the date of this Agreement or, if earlier, on or prior to the time the
        Prospectus is printed and distributed to any Underwriter, or will make
        such filing at such later date as shall have been consented to by CSFBC.

             (b) The Company will advise CSFBC promptly of any proposal to amend
        or supplement the initial or any additional registration statement as
        filed or the related prospectus or the Initial Registration Statement,
        the Additional Registration Statement (if any) or the Prospectus and
        will not effect such amendment or supplementation without CSFBC's
        consent; and the Company will also advise CSFBC promptly of the
        effectiveness of each Registration Statement (if its Effective Time is
        subsequent to the execution and delivery of this Agreement) and of any
        amendment or supplementation of a Registration Statement or the
        Prospectus and of the institution by the Commission of any stop order
        proceedings in respect of a Registration Statement and will use its best
        efforts to prevent the issuance of any such stop order and to obtain as
        soon as possible its lifting, if issued.



                                       10
<PAGE>   11

             (c) If, at any time when a prospectus relating to the Offered
        Securities is required to be delivered under the Act in connection with
        sales by any Underwriter or dealer, any event occurs as a result of
        which the Prospectus as then amended or supplemented would include an
        untrue statement of a material fact or omit to state any material fact
        necessary to make the statements therein, in the light of the
        circumstances under which they were made, not misleading, or if it is
        necessary at any time to amend the Prospectus to comply with the Act,
        the Company will promptly notify CSFBC of such event and will promptly
        prepare and file with the Commission, at its own expense, an amendment
        or supplement which will correct such statement or omission or an
        amendment which will effect such compliance. Neither CSFBC's consent to,
        nor the Underwriters' delivery of, any such amendment or supplement
        shall constitute a waiver of any of the conditions set forth in Section
        6.

             (d) As soon as practicable, but not later than the Availability
        Date (as defined below), the Company will make generally available to
        its securityholders an earnings statement covering a period of at least
        twelve (12) months beginning after the Effective Date of the Initial
        Registration Statement (or, if later, the Effective Date of the
        Additional Registration Statement) which will satisfy the provisions of
        Section 11(a) of the Act. For the purpose of the preceding sentence,
        "AVAILABILITY DATE" means the 45th day after the end of the fourth
        fiscal quarter following the fiscal quarter that includes such Effective
        Date, except that, if such fourth fiscal quarter is the last quarter of
        the Company's fiscal year, "AVAILABILITY DATE" means the 90th day after
        the end of such fourth fiscal quarter.

             (e) The Company will furnish to the Representatives copies of each
        Registration Statement (five (5) of which will be signed and will
        include all exhibits), each related preliminary prospectus, and, so long
        as a prospectus relating to the Offered Securities is required to be
        delivered under the Act in connection with sales by any Underwriter or
        dealer, the Prospectus and all amendments and supplements to such
        documents, in each case in such quantities as CSFBC requests. The
        Prospectus shall be so furnished on or prior to 3:00 P.M., New York
        time, on the business day following the later of the execution and
        delivery of this Agreement or the Effective Time of the Initial
        Registration Statement. All other documents shall be so furnished as
        soon as available. The Company will pay the expenses of printing and
        distributing to the Underwriters all such documents.

             (f) The Company will arrange for the qualification of the Offered
        Securities for sale under the laws of such jurisdictions as CSFBC
        designates and will continue such qualifications in effect so long as
        required for the distribution.

             (g) During the period of five (5) years hereafter, the Company will
        furnish to the Representatives and, upon request, to each of the other
        Underwriters, as soon as practicable after the end of each fiscal year,
        a copy of its annual report to stockholders for such year; and the
        Company will furnish to the Representatives (i) as soon as available, a
        copy of each report and any definitive proxy statement of the Company
        filed


                                       11
<PAGE>   12

        with the Commission under the Securities Exchange Act of 1934 or mailed
        to stockholders, and (ii) from time to time, such other information
        concerning the Company as CSFBC may reasonably request.

             (h) The Company will pay all expenses incident to the performance
        of its obligations under this Agreement, for any filing fees and other
        expenses (including fees and disbursements of counsel) incurred in
        connection with qualification of the Offered Securities for sale for the
        filing fee incident to, and the reasonable fees and disbursements of
        counsel to the Underwriters in connection with, the review by the
        National Association of Securities Dealers, Inc. of the Offered
        Securities, for any travel expenses of the Company's officers and
        employees and any other expenses of the Company in connection with
        attending or hosting meetings with prospective purchasers of the Offered
        Securities and for expenses incurred in distributing preliminary
        prospectuses and the Prospectus (including any amendments and
        supplements thereto) to the Underwriters.

             (i) For a period of ninety (90) days after the date of the initial
        public offering of the Offered Securities, the Company will not offer,
        sell, contract to sell, pledge or otherwise dispose of, directly or
        indirectly, or file with the Commission a registration statement under
        the Act relating to, any additional shares of its Securities or
        securities convertible into or exchangeable or exercisable for any
        shares of its Securities, or publicly disclose the intention to make any
        such offer, sale, pledge, disposition or filing, without the prior
        written consent of CSFBC, except issuances of Securities pursuant to the
        conversion or exchange of convertible or exchangeable securities or the
        exercise of warrants or options, in each case outstanding on the date
        hereof, grants of employee stock options pursuant to the terms of a plan
        in effect on the date hereof, or issuances of Securities pursuant to the
        exercise of such options.

        6. Conditions of the Obligations of the Underwriters. The obligations of
the several Underwriters to purchase and pay for the Firm Securities on the
First Closing Date and the Optional Securities to be purchased on each Optional
Closing Date will be subject to the accuracy of the representations and
warranties on the part of the Company herein, to the accuracy of the statements
of Company officers made pursuant to the provisions hereof, to the performance
by the Company of its obligations hereunder and to the following additional
conditions precedent:

             (a) The Representatives shall have received a letter, dated the
        date of delivery thereof (which, if the Effective Time of the Initial
        Registration Statement is prior to the execution and delivery of this
        Agreement, shall be on or prior to the date of this Agreement or, if the
        Effective Time of the Initial Registration Statement is subsequent to
        the execution and delivery of this Agreement, shall be prior to the
        filing of the amendment or post-effective amendment to the registration
        statement to be filed shortly prior to such Effective Time), of Ernst &
        Young LLP confirming that they are independent public accountants within
        the meaning of the Act and the applicable published Rules and
        Regulations thereunder and stating to the effect that:



                                       12
<PAGE>   13

                    (i) in their opinion the financial statements and schedules
             examined by them and included in the Registration Statements comply
             as to form in all material respects with the applicable accounting
             requirements of the Act and the related published Rules and
             Regulations;

                    (ii) they have performed the procedures specified by the
             American Institute of Certified Public Accountants for a review of
             interim financial information as described in Statement of Auditing
             Standards No. 71, Interim Financial Information, on the unaudited
             financial statements included in the Registration Statements;

                    (iii) on the basis of the review referred to in clause (ii)
             above, a reading of the latest available interim financial
             statements of the Company, inquiries of officials of the Company
             who have responsibility for financial and accounting matters and
             other specified procedures, nothing came to their attention that
             caused them to believe that:

                         (A) the unaudited financial statements included in the
                    Registration Statements do not comply as to form in all
                    materials respects with the applicable accounting
                    requirements of the Act and the related published Rules and
                    Regulations or any material modifications should be made to
                    such unaudited financial statements for them to be in
                    conformity with generally accepted accounting principles;

                         (B) at the date of the latest available balance sheet
                    read by such accountants, or at a subsequent specified date
                    not more than three (3) business days prior to the date of
                    this Agreement, there was any change in the capital stock or
                    any increase in short-term indebtedness or long-term debt of
                    the Company and its consolidated subsidiaries or, at the
                    date of the latest available balance sheet read by such
                    accountants, there was any decrease in consolidated net
                    assets, as compared with amounts shown on the latest balance
                    sheet included in the Prospectus; or

                         (C) for the period from the closing date of the latest
                    income statement included in the Prospectus to the closing
                    date of the latest available income statement read by such
                    accountants there were any decreases, as compared with the
                    corresponding period of the previous year and with the
                    period of corresponding length ended the date of the latest
                    income statement included in the Prospectus, in consolidated
                    net sales, net operating income, or in the total or per
                    share amounts of consolidated net income,

             except in all cases set forth in clauses(B) and (C) above for
             changes, increases or decreases which the Prospectus discloses have
             occurred or may occur or which are described in such letter; and



                                       13
<PAGE>   14

                    (iv) they have compared specified dollar amounts (or
             percentages derived from such dollar amounts) and other financial
             information contained in the Registration Statements (in each case
             to the extent that such dollar amounts, percentages and other
             financial information are derived from the general accounting
             records of the Company and its subsidiaries subject to the internal
             controls of the Company's accounting system or are derived directly
             from such records by analysis or computation) with the results
             obtained from inquiries, a reading of such general accounting
             records and other procedures specified in such letter and have
             found such dollar amounts, percentages and other financial
             information to be in agreement with such results, except as
             otherwise specified in such letter.

        For purposes of this subsection, (i) if the Effective Time of the
        Initial Registration Statement is subsequent to the execution and
        delivery of this Agreement, "REGISTRATION STATEMENTS" shall mean the
        initial registration statement as proposed to be amended by the
        amendment or post-effective amendment to be filed shortly prior to its
        Effective Time, (ii) if the Effective Time of the Initial Registration
        Statement is prior to the execution and delivery of this Agreement but
        the Effective Time of the Additional Registration is subsequent to such
        execution and delivery, "REGISTRATION STATEMENTS" shall mean the Initial
        Registration Statement and the additional registration statement as
        proposed to be filed or as proposed to be amended by the post-effective
        amendment to be filed shortly prior to its Effective Time, and (iii)
        "PROSPECTUS" shall mean the Prospectus included in the Registration
        Statements.

        All financial statements and schedules included in material incorporated
        by reference into the Prospectus shall be deemed included in the
        Registration Statements for purposes of this subsection.

             (b) If the Effective Time of the Initial Registration Statement is
        not prior to the execution and delivery of this Agreement, such
        Effective Time shall have occurred not later than 10:00 P.M., New York
        time, on the date of this Agreement or such later date as shall have
        been consented to by CSFBC. If the Effective Time of the Additional
        Registration Statement (if any) is not prior to the execution and
        delivery of this Agreement, such Effective Time shall have occurred not
        later than 10:00 P.M., New York time, on the date of this Agreement or,
        if earlier, the time the Prospectus is printed and distributed to any
        Underwriter, or shall have occurred at such later date as shall have
        been consented to by CSFBC. If the Effective Time of the Initial
        Registration Statement is prior to the execution and delivery of this
        Agreement, the Prospectus shall have been filed with the Commission in
        accordance with the Rules and Regulations and Section 5(a) of this
        Agreement. Prior to such Closing Date, no stop order suspending the
        effectiveness of a Registration Statement shall have been issued and no
        proceedings for that purpose shall have been instituted or, to the
        knowledge of the Company or the Representatives, shall be contemplated
        by the Commission.



                                       14
<PAGE>   15

             (c) Subsequent to the execution and delivery of this Agreement,
        there shall not have occurred (i) any change, or any development or
        event involving a prospective change, in the condition (financial or
        other), business, properties or results of operations of the Company and
        its subsidiaries taken as one enterprise which, in the judgment of a
        majority in interest of the Underwriters including the Representatives,
        is material and adverse and makes it impractical or inadvisable to
        proceed with completion of the public offering or the sale of and
        payment for the Offered Securities; (ii) any downgrading in the rating
        of any debt securities of the Company by any "nationally recognized
        statistical rating organization" (as defined for purposes of Rule 436(g)
        under the Act), or any public announcement that any such organization
        has under surveillance or review its rating of any debt securities of
        the Company (other than an announcement with positive implications of a
        possible upgrading, and no implication of a possible downgrading, of
        such rating); (iii) any material suspension or material limitation of
        trading in securities generally on the New York Stock Exchange or The
        Nasdaq Stock Market's National Market, or any setting of minimum prices
        for trading on such exchange, or any suspension of trading of any
        securities of the Company on any exchange or in the over-the-counter
        market; (iv) any banking moratorium declared by U.S. Federal or, New
        York authorities; or (v) any outbreak or escalation of major hostilities
        in which the United States is involved, any declaration of war by
        Congress or any other substantial national or international calamity or
        emergency if, in the judgment of a majority in interest of the
        Underwriters including the Representatives, the effect of any such
        outbreak, escalation, declaration, calamity or emergency makes it
        impractical or inadvisable to proceed with completion of the public
        offering or the sale of and payment for the Offered Securities.

             (d) The Representatives shall have received an opinion, dated such
        Closing Date, of Gray Cary Ware and Freidenrich LLP, counsel for the
        Company, to the effect that:

                    (i) Each of the Company and its subsidiaries has been duly
             incorporated and is an existing corporation in good standing under
             the laws of the State of Delaware, with corporate power and
             authority to own its properties and conduct its business as
             described in the Prospectus; and each of the Company and its
             subsidiaries is duly qualified to do business as a foreign
             corporation in good standing in all other jurisdictions in which
             its ownership or lease of property or the conduct of its business
             requires such qualification;

                    (ii) The Offered Securities delivered on such Closing Date
             and all other outstanding shares of the Common Stock of the Company
             have been duly authorized and validly issued, are fully paid and
             nonassessable and conform to the description thereof contained in
             the Prospectus; and the stockholders of the Company have no
             preemptive rights with respect to the Securities;

                    (iii) There are no contracts, agreements or understandings
             known to such counsel between the Company and any person granting
             such person the right to require the Company to file a registration
             statement under the Act with respect



                                       15
<PAGE>   16

             to any securities of the Company owned or to be owned by such
             person or to require the Company to include such securities in the
             securities registered pursuant to the Registration Statement or in
             any securities being registered pursuant to any other registration
             statement filed by the Company under the Act;

                    (iv) The Company is not and, after giving effect to the
             offering and sale of the Offered Securities and the application of
             the proceeds thereof as described in the Prospectus, will not be an
             "investment company" as defined in the Investment Company Act of
             1940.

                    (v) No consent, approval, authorization or order of, or
             filing with, any governmental agency or body or any court is
             required for the consummation of the transactions contemplated by
             this Agreement in connection with the issuance or sale of the
             Offered Securities by the Company, except such as have been
             obtained and made under the Act and such as may be required under
             state securities laws;

                    (vi) Except as disclosed in the Prospectus, such counsel
             does not know of any legal or governmental proceedings pending or
             threatened to which the Company or any of its subsidiaries is or
             could be a party or to which any of their respective property is or
             could be subject, which might result, singly or in the aggregate,
             in a Material Adverse Effect;

                    (vii) The Company is not and, after giving effect to the
             offering and sale of the Notes and the application of the net
             proceeds thereof as described in the Prospectus, will not be, an
             "investment company" as such term is defined in the Investment
             Company Act of 1940, as amended;

                    (viii) The execution, delivery and performance of this
             Agreement and the issuance and sale of the Offered Securities will
             not result in a breach or violation of any of the terms and
             provisions of, or constitute a default under, any statute, any
             rule, regulation or order of any governmental agency or body or any
             court having jurisdiction over the Company or any subsidiary of the
             Company or any of their properties, or any agreement or instrument
             to which the Company or any such subsidiary is a party or by which
             the Company or any such subsidiary is bound or to which any of the
             properties of the Company or any such subsidiary is subject, or the
             charter or by-laws of the Company or any such subsidiary, and the
             Company has full power and authority to authorize, issue and sell
             the Offered Securities as contemplated by this Agreement;

                    (ix) The Initial Registration Statement was declared
             effective under the Act as of the date and time specified in such
             opinion, the Additional Registration Statement (if any) was filed
             and became effective under the Act as of the date and time (if
             determinable) specified in such opinion, the Prospectus either was
             filed with the Commission pursuant to the subparagraph of Rule
             424(b) specified in such opinion on the date specified therein or
             was included in the Initial



                                       16
<PAGE>   17

             Registration Statement or the Additional Registration Statement (as
             the case may be), and, to the best of the knowledge of such
             counsel, no stop order suspending the effectiveness of a
             Registration Statement or any part thereof has been issued and no
             proceedings for that purpose have been instituted or are pending or
             contemplated under the Act, and each Registration Statement and the
             Prospectus, and each amendment or supplement thereto, as of their
             respective effective or issue dates, complied as to form in all
             material respects with the requirements of the Act and the Rules
             and Regulations; such counsel have no reason to believe that any
             part of a Registration Statement or any amendment thereto, as of
             its effective date or as of such Closing Date, contained any untrue
             statement of a material fact or omitted to state any material fact
             required to be stated therein or necessary to make the statements
             therein not misleading or that the Prospectus or any amendment or
             supplement thereto, as of its issue date or as of such Closing
             Date, contained any untrue statement of a material fact or omitted
             to state any material fact necessary in order to make the
             statements therein, in the light of the circumstances under which
             they were made, not misleading; the descriptions in the
             Registration Statements and Prospectus of statutes, legal and
             governmental proceedings and contracts and other documents are
             accurate and fairly present the information required to be shown;
             and such counsel do not know of any legal or governmental
             proceedings required to be described in a Registration Statement or
             the Prospectus which are not described as required or of any
             contracts or documents of a character required to be described in a
             Registration Statement or the Prospectus or to be filed as exhibits
             to a Registration Statement which are not described and filed as
             required; it being understood that such counsel need express no
             opinion as to the financial statements or other financial data
             contained in the Registration Statements or the Prospectus; and

                    (x) All contracts and other agreements to which the Company
             or any of its subsidiaries is a party that are described in the
             Prospectus are accurately described therein.

                    (xi) This Agreement has been duly authorized, executed and
             delivered by the Company.

                    (xii) The information required to be set forth in the
             Registration Statement under the captions "Description of Capital
             Stock," and "Business - Legal Proceedings" is to our knowledge
             accurately and adequately set forth therein in all material
             respects.

             (e) You shall have received on the Closing Dates, if any, an
        opinion (satisfactory to you and counsel for the Underwriters), dated
        the Closing Date, as the case may be, of Townsend and Townsend and Crew
        LLP, patent counsel for the Company, to the effect that:



                                       17
<PAGE>   18

                    (i) To the such patent counsel's knowledge, the statements
             with respect to patent matters in (A) the Prospectus under the
             captions "Risk Factors--Our humanization patents are being opposed
             and a successful challenge could limit our future revenues," "Risk
             Factors--If we are unable to protect our patents and proprietary
             technology, we may not be able to compete successfully" and "Risk
             Factors--We may require additional patent licenses in order to
             manufacture or sell our potential products," (B) the Company's
             annual report on Form 10-K for the fiscal year ended December 31,
             1998 under the captions "Business--Patents and Proprietary
             Technology," "Risk Factors--Uncertainty of Patents and Proprietary
             Technology; Opposition Proceedings" and "Item 3. Legal
             Proceedings," (C) the Company's quarterly report on Form 10-Q for
             the quarterly period ended March 31, 1999 under the caption "Risk
             Factors--Uncertainty of Patents and Proprietary Technology;
             Opposition Proceedings," (D) the Company's quarterly report on Form
             10-Q for the quarterly period ended June 30, 1999 under the caption
             "Risk Factors--Uncertainty of Patents and Proprietary Technology;
             Opposition Proceedings," and (E) the Company's quarterly report on
             Form 10-Q for the quarterly period ended September 30, 1999 under
             the caption "Risk Factors--Uncertainty of Patents and Proprietary
             Technology; Opposition Proceedings" (collectively, the "Patent
             Paragraphs") are accurate in all material respects and fairly
             present the information disclosed therein;

                    (ii) To such patent counsel's knowledge, such patent counsel
             believes that the statements in the Patent Paragraphs do not
             contain any untrue statement of material fact nor omit to state a
             material fact necessary in order to make the statements therein, in
             the light of the circumstances under which they were made, not
             misleading; and

                    (iii) To such patent counsel's knowledge, except as referred
             to in the Patent Paragraphs, there are no legal proceedings
             relating to patent rights of the Company to which the Company is a
             party and no such proceedings are threatened or contemplated.

             (f) You shall have received on the Closing Dates, if any, an
        opinion (satisfactory to you and counsel for the Underwriters), dated
        the Closing Date or such Option Closing Date, as the case may be, of
        Hepworth Lawrence Bryer and Bizley, patent counsel for the Company, to
        the effect that:

                    (i) Such counsel has reviewed the Patent Paragraphs and, to
             the best of such patent counsel's knowledge and belief, the
             statements made therein are accurate in all material respects and
             fairly present the information required to be shown; and such
             counsel does not know of any legal or governmental proceedings
             required to be described in a Registration Statement or the
             Prospectus which are not described as required or of any contracts
             or documents of a character required to be described in a
             Registration Statement or disclosed therein; and



                                       18
<PAGE>   19

                    (ii) To the best of such patent counsel's knowledge and
             belief, no untrue statements of material fact are made in the
             Patent Paragraphs, nor has any material fact been omitted which is
             necessary to make the statements therein not misleading.

             (g) The Representatives shall have received from Skadden, Arps,
        Slate, Meagher & Flom LLP, counsel for the Underwriters, such opinion or
        opinions, dated such Closing Date, with respect to the incorporation of
        the Company, the validity of the Offered Securities delivered on such
        Closing Date, the Registration Statements, the Prospectus and other
        related matters as the Representatives may require, and the Company
        shall have furnished to such counsel such documents as they request for
        the purpose of enabling them to pass upon such matters.

             (h) The Representatives shall have received a certificate, dated
        such Closing Date, of the President or any Vice President and a
        principal financial or accounting officer of the Company in which such
        officers, to the best of their knowledge after reasonable investigation,
        shall state that: the representations and warranties of the Company in
        this Agreement are true and correct; the Company has complied with all
        agreements and satisfied all conditions on its part to be performed or
        satisfied hereunder at or prior to such Closing Date; no stop order
        suspending the effectiveness of any Registration Statement has been
        issued and no proceedings for that purpose have been instituted or are
        contemplated by the Commission; the Additional Registration Statement
        (if any) satisfying the requirements of subparagraphs (1) and (3) of
        Rule 462(b) was filed pursuant to Rule 462(b), including payment of the
        applicable filing fee in accordance with Rule 111(a) or (b) under the
        Act, prior to the time the Prospectus was printed and distributed to any
        Underwriter; and, subsequent to the [If closing date of latest income
        statement in Prospectus is more recent than latest balance sheet date,
        insert--respective] date[s] of the most recent financial statements in
        the Prospectus, there has been no material adverse change, nor any
        development or event involving a prospective material adverse change, in
        the condition (financial or other), business, properties or results of
        operations of the Company and its subsidiaries taken as a whole except
        as set forth in or contemplated by the Prospectus or as described in
        such certificate.

             (i) The Representatives shall have received a letter, dated such
        Closing Date, of Ernst & Young LLP which meets the requirements of
        subsection (a) of this Section, except that the specified date referred
        to in such subsection will be a date not more than three (3) days prior
        to such Closing Date for the purposes of this subsection.

             (j) On or prior to the date of this Agreement, the Representatives
        shall have received lockup letters from each of the executive officers
        and directors of the Company.

The Company will furnish the Representatives with such conformed copies of such
opinions, certificates, letters and documents as the Representatives reasonably
request. CSFBC may in its sole discretion waive on behalf of the Underwriters
compliance with any conditions to the



                                       19
<PAGE>   20

obligations of the Underwriters hereunder, whether in respect of an Optional
Closing Date or otherwise.

        7. Indemnification and Contribution.

             (a) The Company will indemnify and hold harmless each Underwriter,
        its partners, directors and officers and each person, if any, who
        controls such Underwriter within the meaning of Section 15 of the Act,
        against any losses, claims, damages or liabilities, joint or several, to
        which such Underwriter may become subject, under the Act or otherwise,
        insofar as such losses, claims, damages or liabilities (or actions in
        respect thereof) arise out of or are based upon any untrue statement or
        alleged untrue statement of any material fact contained in any
        Registration Statement, the Prospectus, or any amendment or supplement
        thereto, or any related preliminary prospectus, or arise out of or are
        based upon the omission or alleged omission to state therein a material
        fact required to be stated therein or necessary to make the statements
        therein not misleading, and will reimburse each Underwriter for any
        legal or other expenses reasonably incurred by such Underwriter in
        connection with investigating or defending any such loss, claim, damage,
        liability or action as such expenses are incurred; provided, however,
        that the Company will not be liable in any such case to the extent that
        any such loss, claim, damage or liability arises out of or is based upon
        an untrue statement or alleged untrue statement in or omission or
        alleged omission from any of such documents in reliance upon and in
        conformity with written information furnished to the Company by any
        Underwriter through the Representatives specifically for use therein, it
        being understood and agreed that the only such information furnished by
        any Underwriter consists of the information described as such in
        subsection (b) below.

             (b) Each Underwriter will severally and not jointly indemnify and
        hold harmless the Company, its directors and officers and each person,
        if any who controls the Company within the meaning of Section 15 of the
        Act, against any losses, claims, damages or liabilities to which the
        Company may become subject, under the Act or otherwise, insofar as such
        losses, claims, damages or liabilities (or actions in respect thereof)
        arise out of or are based upon any untrue statement or alleged untrue
        statement of any material fact contained in any Registration Statement,
        the Prospectus, or any amendment or supplement thereto, or any related
        preliminary prospectus, or arise out of or are based upon the omission
        or the alleged omission to state therein a material fact required to be
        stated therein or necessary to make the statements therein not
        misleading, in each case to the extent, but only to the extent, that
        such untrue statement or alleged untrue statement or omission or alleged
        omission was made in reliance upon and in conformity with written
        information furnished to the Company by such Underwriter through the
        Representatives specifically for use therein, and will reimburse any
        legal or other expenses reasonably incurred by the Company in connection
        with investigating or defending any such loss, claim, damage, liability
        or action as such expenses are incurred, it being understood and agreed
        that the only such information furnished by any Underwriter consists of
        the following information in the Prospectus furnished on behalf



                                       20
<PAGE>   21

        of each Underwriter: the concession and reallowance figures appearing in
        the _______ paragraph under the caption "Underwriting."

             (c) Promptly after receipt by an indemnified party under this
        Section of notice of the commencement of any action, such indemnified
        party will, if a claim in respect thereof is to be made against the
        indemnifying party under subsection (a) or (b) above, notify the
        indemnifying party of the commencement thereof; but the omission so to
        notify the indemnifying party will not relieve it from any liability
        which it may have to any indemnified party otherwise than under
        subsection (a) or (b) above. In case any such action is brought against
        any indemnified party and it notifies the indemnifying party of the
        commencement thereof, the indemnifying party will be entitled to
        participate therein and, to the extent that it may wish, jointly with
        any other indemnifying party similarly notified, to assume the defense
        thereof, with counsel satisfactory to such indemnified party (who shall
        not, except with the consent of the indemnified party, be counsel to the
        indemnifying party), and after notice from the indemnifying party to
        such indemnified party of its election so to assume the defense thereof,
        the indemnifying party will not be liable to such indemnified party
        under this Section for any legal or other expenses subsequently incurred
        by such indemnified party in connection with the defense thereof other
        than reasonable costs of investigation. No indemnifying party shall,
        without the prior written consent of the indemnified party, effect any
        settlement of any pending or threatened action in respect of which any
        indemnified party is or could have been a party and indemnity could have
        been sought hereunder by such indemnified party unless such settlement
        (i) includes an unconditional release of such indemnified party from all
        liability on any claims that are the subject matter of such action and
        (ii) does not include a statement as to, or an admission of, fault,
        culpability or a failure to act by or on behalf of an indemnified party.

             (d) If the indemnification provided for in this Section is
        unavailable or insufficient to hold harmless an indemnified party under
        subsection (a) or (b) above, then each indemnifying party shall
        contribute to the amount paid or payable by such indemnified party as a
        result of the losses, claims, damages or liabilities referred to in
        subsection (a) or (b) above (i) in such proportion as is appropriate to
        reflect the relative benefits received by the Company on the one hand
        and the Underwriters on the other from the offering of the Securities or
        (ii) if the allocation provided by clause (i) above is not permitted by
        applicable law, in such proportion as is appropriate to reflect not only
        the relative benefits referred to in clause (i) above but also the
        relative fault of the Company on the one hand and the Underwriters on
        the other in connection with the statements or omissions which resulted
        in such losses, claims, damages or liabilities as well as any other
        relevant equitable considerations. The relative benefits received by the
        Company on the one hand and the Underwriters on the other shall be
        deemed to be in the same proportion as the total net proceeds from the
        offering (before deducting expenses) received by the Company bear to the
        total underwriting discounts and commissions received by the
        Underwriters. The relative fault shall be determined by reference to,
        among other things, whether the untrue or alleged untrue statement of a
        material fact or the omission or alleged omission to state a material
        fact relates to information supplied



                                       21
<PAGE>   22

        by the Company or the Underwriters and the parties' relative intent,
        knowledge, access to information and opportunity to correct or prevent
        such untrue statement or omission. The amount paid by an indemnified
        party as a result of the losses, claims, damages or liabilities referred
        to in the first sentence of this subsection (d) shall be deemed to
        include any legal or other expenses reasonably incurred by such
        indemnified party in connection with investigating or defending any
        action or claim which is the subject of this subsection (d).
        Notwithstanding the provisions of this subsection (d), no Underwriter
        shall be required to contribute any amount in excess of the amount by
        which the total price at which the Securities underwritten by it and
        distributed to the public were offered to the public exceeds the amount
        of any damages which such Underwriter has otherwise been required to pay
        by reason of such untrue or alleged untrue statement or omission or
        alleged omission. No person guilty of fraudulent misrepresentation
        (within the meaning of Section 11(f) of the Act) shall be entitled to
        contribution from any person who was not guilty of such fraudulent
        misrepresentation. The Underwriters' obligations in this subsection (d)
        to contribute are several in proportion to their respective underwriting
        obligations and not joint.

             (e) The obligations of the Company under this Section shall be in
        addition to any liability which the Company may otherwise have and shall
        extend, upon the same terms and conditions, to each person, if any, who
        controls any Underwriter within the meaning of the Act; and the
        obligations of the Underwriters under this Section shall be in addition
        to any liability which the respective Underwriters may otherwise have
        and shall extend, upon the same terms and conditions, to each director
        of the Company, to each officer of the Company who has signed a
        Registration Statement and to each person, if any, who controls the
        Company within the meaning of the Act.

        8. Default of Underwriters. If any Underwriter or Underwriters default
in their obligations to purchase Offered Securities hereunder on either the
First or any Optional Closing Date and the aggregate number of shares of Offered
Securities that such defaulting Underwriter or Underwriters agreed but failed to
purchase does not exceed 10% of the total number of shares of Offered Securities
that the Underwriters are obligated to purchase on such Closing Date, CSFBC may
make arrangements satisfactory to the Company for the purchase of such Offered
Securities by other persons, including any of the Underwriters, but if no such
arrangements are made by such Closing Date, the non-defaulting Underwriters
shall be obligated severally, in proportion to their respective commitments
hereunder, to purchase the Offered Securities that such defaulting Underwriters
agreed but failed to purchase on such Closing Date. If any Underwriter or
Underwriters so default and the aggregate number of shares of Offered Securities
with respect to which such default or defaults occur exceeds 10% of the total
number of shares of Offered Securities that the Underwriters are obligated to
purchase on such Closing Date and arrangements satisfactory to CSFBC and the
Company for the purchase of such Offered Securities by other persons are not
made within 36 hours after such default, this Agreement will terminate without
liability on the part of any non-defaulting Underwriter or the Company, except
as provided in Section 9 (provided that if such default occurs with respect to
Optional Securities after the First Closing Date, this Agreement will not
terminate as to the Firm Securities or any Optional Securities purchased prior
to such termination). As used in this Agreement, the term



                                       22
<PAGE>   23

"Underwriter" includes any person substituted for an Underwriter under this
Section. Nothing herein will relieve a defaulting Underwriter from liability for
its default.

        9. Survival of Certain Representations and Obligations. The respective
indemnities, agreements, representations, warranties and other statements of the
Company or its officers and of the several Underwriters set forth in or made
pursuant to this Agreement will remain in full force and effect, regardless of
any investigation, or statement as to the results thereof, made by or on behalf
of any Underwriter, the Company or any of their respective representatives,
officers or directors or any controlling person, and will survive delivery of
and payment for the Offered Securities. If this Agreement is terminated pursuant
to Section 8 or if for any reason the purchase of the Offered Securities by the
Underwriters is not consummated, the Company shall remain responsible for the
expenses to be paid or reimbursed by it pursuant to Section 5 and the respective
obligations of the Company and the Underwriters pursuant to Section 7 shall
remain in effect, and if any Offered Securities have been purchased hereunder
the representations and warranties in Section 2 and all obligations under
Section 5 shall also remain in effect. If the purchase of the Offered Securities
by the Underwriters is not consummated for any reason other than solely because
of the termination of this Agreement pursuant to Section 8 or the occurrence of
any event specified in clause (iii), (iv) or (v) of Section 6(c), the Company
will reimburse the Underwriters for all out-of-pocket expenses (including fees
and disbursements of counsel) reasonably incurred by them in connection with the
offering of the Offered Securities.

        10. Notices. All communications hereunder will be in writing and, if
sent to the Underwriters, will be mailed, delivered or telegraphed and confirmed
to the Representatives, c/o Credit Suisse First Boston Corporation, Eleven
Madison Avenue, New York, NY 10010-3629, Attention: Investment Banking
Department--Transactions Advisory Group, with a copy to Skadden, Arps, Slate,
Meagher & Flom LLP, 525 University Avenue, Suite 220, Palo Alto, California
94301, Attention: Gregory C. Smith, or, if sent to the Company, will be mailed,
delivered or telegraphed and confirmed to it at 34801 Campus Drive, Fremont,
California 94555, Attention: Laurence Korn, with a copy to Gray Cary Ware &
Freidenrich LLP, 400 Hamilton Avenue, Palo Alto, California 94301, Attention:
Gregory M. Gallo; provided, however, that any notice to an Underwriter pursuant
to Section 7 will be mailed, delivered or telegraphed and confirmed to such
Underwriter.

        11. Successors. This Agreement will inure to the benefit of and be
binding upon the parties hereto and their respective successors and the officers
and directors and controlling persons referred to in Section 7, and no other
person will have any right or obligation hereunder.

        12. Representation of Underwriters. The Representatives will act for the
several Underwriters in connection with this financing, and any action under
this Agreement taken by the Representatives jointly or by CSFBC will be binding
upon all the Underwriters.

        13. Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be deemed to be an original, but all such
counterparts shall together constitute one and the same Agreement.



                                       23
<PAGE>   24

        14. APPLICABLE LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED
IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO
PRINCIPLES OF CONFLICTS OF LAWS.

        The Company hereby submits to the non-exclusive jurisdiction of the
Federal and state courts in the Borough of Manhattan in The City of New York in
any suit or proceeding arising out of or relating to this Agreement or the
transactions contemplated hereby.



                                       24
<PAGE>   25

        If the foregoing is in accordance with the Representatives'
understanding of our agreement, kindly sign and return to the Company one of the
counterparts hereof, whereupon it will become a binding agreement between the
Company and the several Underwriters in accordance with its terms.

                                       Very truly yours,

                                       PROTEIN DESIGN LABS, INC.

                                       By:
                                          ------------------------------------
                                       Name:  Laurence Jay Korn
                                       Title: Chief Executive Officer

The foregoing Underwriting Agreement
is hereby confirmed and accepted as of
the date first above written.


CREDIT SUISSE FIRST BOSTON CORPORATION

-----------------------------------

-----------------------------------

Acting on behalf of themselves and as the
Representatives of the several Underwriters


By: CREDIT SUISSE FIRST BOSTON CORPORATION


By:
   -----------------------------------
Name:
Title:



                                       1
<PAGE>   26


                                   SCHEDULE A


<TABLE>
<CAPTION>
                                                                              Principal Amount of
                  Underwriter                                                   Firm Securities
                  -----------                                                   ---------------
<S>                                                                           <C>
Credit Suisse First Boston Corporation.................................       [$]
[____________________].................................................       [___________________]
[____________________].................................................       [___________________]
[____________________].................................................       [___________________]












                                                                               -------------------
           Total.......................................................        [$]
                                                                               ===================
</TABLE>



                                       2



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