MATRIX PHARMACEUTICAL INC/DE
SC 13D/A, 1996-06-11
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13D


                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 1)*


                           Matrix Pharmaceutical, Inc.
- --------------------------------------------------------------------------------
                                (NAME OF ISSUER)


                     Common Stock, Par Value $0.01 Per Share
- --------------------------------------------------------------------------------
                         (TITLE OF CLASS OF SECURITIES)


                                   576844 10 4
- --------------------------------------------------------------------------------
                                 (CUSIP NUMBER)

                                  Harry T. Rein
                                 Canaan Partners
                               105 Rowayton Avenue
                               Rowayton, CT 06853
                                 (203) 855-0400
- --------------------------------------------------------------------------------
  (Name, Address and Telephone Number of Person Authorized to Receive Notices
                               and Communications)


                                 April 29, 1996
                       ------------------------------------
             (DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box. [ ]

Check the following box if a fee is being paid with the statement [ ]. (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7.)

NOTE: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule  13d-1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



                                                                    Page 1 of 32
                                                Exhibit Index located at Page 28

<PAGE>

<TABLE>


                                                     SCHEDULE 13D
<CAPTION>


- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                      <C>      
CUSIP NO.                              576844 10 4                              PAGE   2     OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Partners, L.P., a Delaware limited partnership ("Canaan Capital Partners")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                        (a) [ ]
                                                                                                                    (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Limited  Partnership and Canaan Capital Offshore Limited Partnership C.V.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER

                              0 shares (See Item 5)
  NUMBER OF                  ----------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY
  OWNED BY                    40,859 shares of Common Stock (See Item 5)
    EACH                   ------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER

                              40,859 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           40,859 shares of Common Stock  (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           0% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>


<PAGE>

<TABLE>


                                                     SCHEDULE 13D
<CAPTION>



- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>      
CUSIP NO.                              576844 10 4                              PAGE   3     OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Offshore Management, N.V., a Netherlands Antilles corporation ("Canaan Capital
           Offshore Management")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Capital Offshore Limited Partnership C.V.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Netherlands Antilles Corporation
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    36,497 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              36,497 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           36,497 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           0% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           CO
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>


<PAGE>

<TABLE>


                                                     SCHEDULE 13D
<CAPTION>


- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                      <C>      
CUSIP NO.                              576844 10 4                              PAGE   4     OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Management Limited Partnership, a Delaware Limited Partnership ("Canaan Capital
           Management")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Limited  Partnership and Canaan Capital Offshore Limited Partnership C.V.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    40,859 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              40,859 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           40,859 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]
     

- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           0% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>


<PAGE>

<TABLE>


                                                     SCHEDULE 13D
<CAPTION>


- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                       <C>      
CUSIP NO.                              576844 10 4                              PAGE   5     OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Offshore Limited Partnership C.V., a Netherlands Antilles Limited Partnership
           ("Canaan Capital Offshore")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Offshore
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]

- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Netherlands Antilles Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              36,497 shares of Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    4,362 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      36,497 shares of Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              4,362 shares of Common Stock  (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           40,859 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           0% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>


<PAGE>

<TABLE>


                                                     SCHEDULE 13D
<CAPTION>


- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>      
CUSIP NO.                              576844 10 4                              PAGE   6     OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Limited Partnership, a Delaware Limited Partnership ("Canaan Capital, L.P.")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital, L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              4,362 shares of Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    36,497 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      4,362 shares of Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              36,497 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           40,859 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           0% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>


<PAGE>


<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE   7     OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan S.B.I.C. Partners, L.P., a Delaware Limited Partnership ("Canaan S.B.I.C. Partners")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan S.B.I.C., L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    84,141 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              84,141 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           84,141 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           0% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>

<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE   8     OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan  S.B.I.C.,  L.P.,  a  Delaware  Limited  Partnership  ("Canaan S.B.I.C., L.P.)
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan S.B.I.C., L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              84,141 shares of Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    0 shares (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      84,141 shares of Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              0 shares (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           84,141 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           0% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE   9     OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Venture Partners, L.P., a Delaware Limited Partnership ("Canaan Venture Partners")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture Offshore Limited Partnership, C.V. and Canaan Venture Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    738,503 shares Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              738,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           738,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.1% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>
<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE   10    OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Offshore Management, N.V., a Netherlands Antilles corporation ("Canaan Offshore
           Management")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture Offshore Limited Partnership, C.V.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Netherlands Antilles Corporation
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    520,644 shares Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              520,644 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           520,644 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           2.9% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           CO
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>

<PAGE>
<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE   11    OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Management Limited Partnership, a Delaware Limited Partnership ("Canaan Management")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture Offshore Limited Partnership, C.V. and Canaan Venture Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    738,503 shares Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              738,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           738,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.1% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>
<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE   12    OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Venture Offshore Limited Partnership, C.V., a Netherlands Antilles Limited Partnership
           ("Canaan Venture Offshore")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture Offshore
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Netherlands Antilles Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              520,644 shares of Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    217,859 shares Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      520,644 shares of Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              217,859 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           738,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.1% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>
<TABLE>
                                                     SCHEDULE 13D
<CAPTION>


- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE   13    OF  32  PAGES
          ----------------------------------------                                   -------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Venture Limited Partnership, a Delaware Limited Partnership ("Canaan Venture, L.P.")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture, L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              217,859 shares of Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    520,644 shares Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      217,859 shares of Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              520,644 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           738,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.1% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>


                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE    14    OF  32  PAGES
          ----------------------------------------                                   --------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Harry T. Rein
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Offshore,  Canaan Capital L.P., Canaan S.B.I.C., L.P., Canaan Venture 
           Offshore and Canaan Venture L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    863,503 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              863,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           863,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.8% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE    15    OF  32  PAGES
          ----------------------------------------                                   --------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           James J. Fitzpatrick
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore,  Canaan Capital L.P., Canaan S.B.I.C., L.P., Canaan Venture
           Offshore and Canaan Venture L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                      [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    863,503 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              863,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           863,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.8% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>
<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE    16    OF  32  PAGES
          ----------------------------------------                                   --------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Stephen L. Green
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY

- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Offshore, Canaan Capital L.P. and Canaan S.B.I.C., L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    125,000 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              125,000 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           125,000 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           0% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>


- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE    17    OF  32  PAGES
          ----------------------------------------                                   --------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Gregory Kopchinsky
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore,  Canaan Capital L.P., Canaan S.B.I.C., L.P., Canaan Venture 
           Offshore and Canaan Venture L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    863,503 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              863,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           863,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.8% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>

                                                     SCHEDULE 13D
<CAPTION>


- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE    18    OF  32  PAGES
          ----------------------------------------                                   --------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Robert J. Migliorino
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore,  Canaan Capital L.P., Canaan S.B.I.C., L.P.,  Canaan Venture
           Offshore and Canaan Venture L.P. (with respect to Common Stock reported in Rows 8 and 10 
           below) and PF (with respect to Common Stock reported in Rows 7 and 9 below)
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              8,000 shares of Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    863,503 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      8,000 shares of Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              863,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           871,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.9% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE    19    OF  32  PAGES
          ----------------------------------------                                   --------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Deepak Kamra
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Offshore,  Canaan Capital L.P., Canaan S.B.I.C., L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    125,000 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              125,000 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           125,000 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           0% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>

<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>


- ----------------------------------------------------                          ------------------------------------------------
<S>       <C>                                                                                                        <C>   
CUSIP NO.                              576844 10 4                              PAGE    20    OF  32  PAGES
          ----------------------------------------                                   --------    ----
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Eric A. Young
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [x]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore,  Canaan Capital L.P., Canaan S.B.I.C., L.P., Canaan Venture 
           Offshore and Canaan Venture L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    863,503 shares of Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              863,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           863,503 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.8% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



          ITEM 2.  IDENTITY  AND  BACKGROUND.  

          The response to Item 2 is hereby  amended by deleting the responses to
paragraph (b) - (c) (for Canaan Capital Partners only) and paragraph (f) thereof
and inserting the following in its place:

           CANAAN CAPITAL PARTNERS

           (b) - (c) Canaan Capital Partners'  principal business address (which
also  serves  as  its  principal  office)  is  105  Rowayton  Avenue,  Rowayton,
Connecticut  06853.  Canaan Capital Partners'  principal business is to serve as
the general partner of Canaan Capital Management. The general partners of Canaan
Capital  Partners  and  their  respective   business   addresses  and  principal
occupations are as follows:

GENERAL PARTNER                      ADDRESS                      OCCUPATION
- ---------------                      -------                      ----------
Harry T. Rein                  105 Rowayton Avenue            General Partner of
                               Rowayton, CT  06853            Canaan Capital
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                           
James J. Fitzpatrick           105 Rowayton Avenue            General Partner of
                               Rowayton, CT  06853            Canaan Capital
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                           
Stephen L. Green               105 Rowayton Avenue            General Partner of
                               Rowayton, CT  06853            Canaan Capital
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                           
Gregory Kopchinsky             105 Rowayton Avenue            General Partner of
                               Rowayton, CT  06853            Canaan Capital
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                           
Robert J. Migliorino           105 Rowayton Avenue            General Partner of
                               Rowayton, CT  06853            Canaan Capital and
                                                              Partners and other
                                                              venture capital
                                                              partnerships

                                  Page 21 of 32

<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D




GENERAL PARTNER                    ADDRESS                     OCCUPATION
- ---------------                    -------                     ----------

Deepak Kamra                    2884 Sand Hill Road           General Partner of
                                Suite 115                     Canaan Capital
                                Menlo Park, CA  94025         Partners and other
                                                              venture capital
                                                              partnerships

Eric A. Young                   2884 Sand Hill Road           General Partner of
                                Suite 115                     Canaan Capital
                                Menlo Park, CA  94025         Partners and other
                                                              venture capital
                                                              partnerships

           (f) All of the persons  identified in this Item 2 are citizens of the
United States of America.


ITEM 5.    INTEREST IN SECURITIES OF THE ISSUER.

           The response to Item 5 is hereby amended by deleting the responses to
paragraphs (a), (b) and (c) thereof and inserting the following in its place:

           (a) Reporting  Persons  currently hold 863,503 shares of Common Stock
constituting  approximately  4.8% of the outstanding  shares of Common Stock (on
the basis of 17,896,742  shares of Common Stock outstanding as of March 31, 1996
according to information  provided by the Issuer in its Quarterly Report on Form
10-Q).

           (b)-(c) Each of the Reporting Persons shares with the other Reporting
Persons  the sole  power to vote or direct  the vote of,  and the sole  power to
dispose of direct the  disposition  of, Shares owned by Canaan Capital  Partners
L.P., Canaan Capital  Management  Limited  Partnership,  Canaan Capital Offshore
Limited  Partnership,  C.V.,  Canaan Capital Limited  Partners,  Canaan S.B.I.C.
Partners,  L.P.,  Canaan S.B.I.C.,  L.P.,  Canaan Venture Partners L.P.,  Canaan
Offshore Management, N.V., Canaan Management Limited Partnership, Canaan Venture
Offshore Limited Partnership, C.V. and Canaan Venture Limited Partnership.

           The  response  to Item 5(e) is amended by  deleting  the entire  text
thereof and inserting in lieu thereof:

           (e) On  April  29,  1996,  the  Reporting  Persons  ceased  to be the
beneficial owner of more than five percent (5%) of the outstanding shares of the
Issuer.


                                  Page 22 of 32

<PAGE>


CUSIP NO.:  576844 10 4                                             SCHEDULE 13D



ITEM 7.    MATERIALS TO BE FILED AS EXHIBITS.

           The following document is filed as an exhibit:

           1. Agreement of Joint Filing.





                                  Page 23 of 32

<PAGE>



                                    SIGNATURE



           After reasonable  inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this Statement is true, complete and
correct.


Dated:  May __, 1996          CANAAN VENTURE LIMITED PARTNERSHIP

                              By:      Canaan Management Limited Partnership,
                                       Its General Partner

                              By:      Canaan Venture Partners L.P.,
                                       Its General Partner


                              By:
                                       ----------------------------------------
                                       Guy M. Russo
                                       Attorney-in-Fact


                              CANAAN VENTURE OFFSHORE LIMITED
                              PARTNERSHIP, C.V.

                              By:      Canaan Management Limited Partnership,
                                       Its General Partner

                              By:      Canaan Venture Partners L.P.,
                                       Its General Partner


                              By:
                                       -----------------------------------------
                                       Guy M. Russo
                                       Attorney-in-Fact


                              CANAAN MANAGEMENT LIMITED
                              PARTNERSHIP

                              By:      Canaan Venture Partners L.P.,
                                       Its General Partner


                              By:
                                       -----------------------------------------
                                       Guy M. Russo
                                       General Partner


                                Page 24 of 32

<PAGE>




                         CANAAN OFFSHORE MANAGEMENT, N.V.


                         By:
                                  ----------------------------------------
                                  President


                         CANAAN VENTURE PARTNERS L.P.


                         By:
                                  -----------------------------------------
                                  Attorney-in-Fact


                         CANAAN CAPITAL LIMITED PARTNERSHIP

                         By:      Canaan Capital Management Limited
                                  Partnership, General Partner

                         By:      Canaan Capital Partners L.P., General Partner


                         By:
                                  -----------------------------------------
                                  Guy M. Russo
                                  Attorney-in-Fact


                         CANAAN CAPITAL OFFSHORE LIMITED
                         PARTNERSHIP C.V.

                         By:      Canaan Capital Management Limited
                                  Partnership, General Partner

                         By:      Canaan Capital Partners L.P., General Partner


                         By:
                                  ------------------------------------------
                                  Guy M. Russo
                                  Attorney-in-Fact



                                  Page 25 of 32

<PAGE>

                         CANAAN CAPITAL MANAGEMENT LIMITED
                         PARTNERSHI

                         By:    Canaan Capital Partners L.P., General Partner


                         By:
                                ------------------------------------------
                                Guy M. Russo
                                Attorney-in-Fact


                         CANAAN CAPITAL PARTNERS L.P.


                         By:
                                ------------------------------------------
                                Guy M. Russo
                                Attorney-in-Fact


                         CANAAN S.B.I.C., L.P.

                         By:    Canaan S.B.I.C. Partners, L.P., General Partner


                         By:
                                ------------------------------------------
                                Guy M. Russo
                                Attorney-in-Fact


                          CANAAN S.B.I.C. PARTNERS, L.P.


                          By:
                                 ------------------------------------------
                                 Guy M. Russo
                                 Attorney-in-Fact



                                  Page 26 of 32
<PAGE>

                           HARRY T. REIN
                           JAMES J. FITZPATRICK
                           STEPHEN L. GREEN
                           GREGORY KOPCHINSKY
                           ROBERT J. MIGLIORINO
                           DEEPAK KAMRA
                           ERIC A. YOUNG


                           By:
                                  ------------------------------------------
                                  Guy M. Russo
                                  Attorney-in-Fact





                                  Page 27 of 32

<PAGE>



                                  EXHIBIT INDEX



                                                                          PAGE
                                                                          ----

1.       Agreement of Joint Filing.                                        29







                                  Page 28 of 32

<PAGE>



                                    EXHIBIT 2


                            Agreement of Joint Filing



                  The  undersigned  hereby agree that a single  Schedule 13D (or
any amendment thereto) relating to Common Stock of Matrix  Pharmaceutical,  Inc.
shall be filed on behalf  of each of the  undersigned  and that  this  Agreement
shall be filed as an Exhibit to such Schedule 13D.

                  This Agreement and the filing of the Schedule 13D shall not be
construed  to be an  admission  that any of the  undersigned  is a  member  of a
"group" consisting of one or more of such persons pursuant to Section 13d of the
Securities Exchange Act of 1934, as amended, and the rules thereunder.

Date:  May __, 1996             CANAAN VENTURE LIMITED PARTNERSHIP

                                By:      Canaan Management Limited Partnership,
                                         Its General Partner

                                By:      Canaan Venture Partners L.P.,
                                         Its General Partner


                                By:
                                         ---------------------------------------
                                         Guy M. Russo
                                         Attorney-in-Fact


                                CANAAN VENTURE OFFSHORE LIMITED
                                PARTNERSHIP, C.V.

                                By:      Canaan Management Limited Partnership,
                                         Its General Partner

                                By:      Canaan Venture Partners L.P.,
                                         Its General Partner


                                By:
                                         ---------------------------------------
                                         Guy M. Russo
                                         Attorney-in-Fact



                                  Page 29 of 32

<PAGE>



                         CANAAN MANAGEMENT LIMITED
                         PARTNERSHIP

                         By:      Canaan Venture Partners L.P.,
                                  Its General Partner


                         By:
                                  ------------------------------------------
                                  Guy M. Russo
                                  Attorney-in-Fact


                         CANAAN OFFSHORE MANAGEMENT, N.V.


                         By:
                                  ------------------------------------------
                                  President


                         CANAAN VENTURE PARTNERS L.P.


                         By:
                                  ------------------------------------------
                                  Attorney-in-Fact


                         CANAAN CAPITAL LIMITED PARTNERSHIP

                         By:      Canaan Capital Management Limited
                                  Partnership, General Partner

                         By:      Canaan Capital Partners L.P., General Partner


                         By:
                                  ------------------------------------------
                                  Guy M. Russo
                                  Attorney-in-Fact



                                  Page 30 of 32

<PAGE>

                       CANAAN CAPITAL OFFSHORE LIMITED
                       PARTNERSHIP C.V.

                       By:      Canaan Capital Management Limited
                                Partnership, General Partner

                       By:      Canaan Capital Partners L.P., General Partner


                       By:
                                ------------------------------------------
                                Guy M. Russo
                                Attorney-in-Fact


                       CANAAN CAPITAL MANAGEMENT LIMITED
                       PARTNERSHIP

                       By:      Canaan Capital Partners L.P., General Partner


                       By:
                                ------------------------------------------
                                Guy M. Russo
                                Attorney-in-Fact


                       CANAAN CAPITAL PARTNERS L.P.


                       By:
                                ------------------------------------------
                                Guy M. Russo
                                Attorney-in-Fact


                       CANAAN S.B.I.C., L.P.

                       By:      Canaan S.B.I.C. Partners, L.P., General Partner


                       By:
                                ------------------------------------------
                                Guy M. Russo
                                Attorney-in-Fact



                                  Page 31 of 32

<PAGE>
                          CANAAN S.B.I.C. PARTNERS, L.P.


                          By:
                                   ------------------------------------------
                                   Guy M. Russo
                                   Attorney-in-Fact


                          HARRY T. REIN
                          JAMES J. FITZPATRICK
                          STEPHEN L. GREEN
                          GREGORY KOPCHINSKY
                          ROBERT J. MIGLIORINO
                          DEEPAK KAMRA
                          ERIC A. YOUNG


                          By:
                                   ------------------------------------------
                                   Guy M. Russo
                                   Attorney-in-Fact


                                  Page 32 of 32

<PAGE>


 (415) 496-2794

                                  June 5, 1996




VIA FEDERAL EXPRESS

Securities and Exchange Commission
450 Fifth Street, N.W.
Judiciary Plaza
Washington, D.C.  20549

                  Re:      SCHEDULE   13D   REGARDING    OWNERSHIP   OF   MATRIX
                           PHARMACEUTICAL,  INC.  COMMON STOCK BY CANAAN CAPITAL
                           PARTNERS  L.P.,  CANAAN  CAPITAL  MANAGEMENT  LIMITED
                           PARTNERSHIP,    CANAAN   CAPITAL   OFFSHORE   LIMITED
                           PARTNERSHIP,    C.V.,    CANAAN    CAPITAL    LIMITED
                           PARTNERSHIP,  CANAAN S.B.I.C.  PARTNERS, L.P., CANAAN
                           S.B.I.C.,  L.P., CANAAN VENTURE PARTNERS L.P., CANAAN
                           OFFSHORE MANAGEMENT,  N.V., CANAAN MANAGEMENT LIMITED
                           PARTNERSHIP,    CANAAN   VENTURE   OFFSHORE   LIMITED
                           PARTNERSHIP,    C.V.,    CANAAN    VENTURE    LIMITED
                           PARTNERSHIP,  AND CERTAIN INDIVIDUALS  (COLLECTIVELY,
                           THE "REPORTING PERSONS")

Ladies and Gentlemen:

                  On behalf of the Reporting  Persons named above,  enclosed for
filing  pursuant to the Securities  Exchange Act of 1934, as amended (the "Act")
and Rule 13d-1 thereunder,  are six copies, including all exhibits, one of which
has been manually signed and sequentially  numbered,  of a Statement on Schedule
13D  (the   "Statement")   relating   to  shares  of  Common   Stock  of  Matrix
Pharmaceutical,  Inc., a Delaware corporation (the "Issuer"). Also enclosed is a
certified  check payable to the SEC for the $100.00  filing fee pursuant to Rule
13d-7 under the Act.

                  Please  acknowledge  receipt of the  enclosed  Schedule 13D by
stamping as received  the enclosed  copy of this letter and  returning it in the
self-addressed, postage-paid envelope provided for your convenience.

<PAGE>


Securities and Exchange                                            June 5, 1996
Commission                                                               Page 2





                  Please feel free to call me at the above  number or J. Stephan
Dolezalek at (415) 496-2842 if you have any questions.

                                Very truly yours,


                                 Lisa A. Sobrato

LAS:jm
Enclosures
cc:      National Association of Securities Dealers, Inc.
         Matrix Pharmaceutical, Inc. (via Certified Mail)
         Mr. Guy M. Russo
         John M. Hession, Esq.
         J. Stephan Dolezalek, Esq.

<PAGE>



                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13D


                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. __)*


                           Matrix Pharmaceutical, Inc.
- -------------------------------------------------------------------------------
                                (NAME OF ISSUER)


                     Common Stock, Par Value $0.01 Per Share
- -------------------------------------------------------------------------------
                         (TITLE OF CLASS OF SECURITIES)


                                   576844 10 4
                    ----------------------------------------
                                 (CUSIP NUMBER)

                                 Alan E. Salzman
                          Canaan Capital Partners, L.P.
                               2884 Sand Hill Road
                                    Suite 115
                          Menlo Park, California 94025
                                 (415) 854-8092

- -------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)


                                December 24, 1994
                  --------------------------------------------
             (DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [X]

Check the following box if a fee is being paid with the statement [X]. (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7.)

NOTE: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule  13d-1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



                                                                   Page 1 of 119
                                                Exhibit Index located at Page 48

<PAGE>
<TABLE>


                                                        SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>        
CUSIP NO.                              576844 10 4                              PAGE   2     OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Partners, L.P., a Delaware limited partnership ("Canaan Capital Partners")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Limited  Partnership and Canaan Capital Offshore Limited Partnership C.V.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  1,349  shares of Series A Preferred  Stock  convertible  into 134,900 shares of 
  OWNED BY                    Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              1,349  shares of Series A Preferred  Stock  convertible  into 134,900 shares of 
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,349 shares of Series A Preferred Stock convertible into 134,900 shares of Common Stock  (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           1.2% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>


<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   3     OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Offshore Management, N.V., a Netherlands Antilles corporation ("Canaan Capital
           Offshore Management")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Capital Offshore Limited Partnership C.V.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Netherlands Antilles Corporation
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  1,205  shares of Series A Preferred  Stock  convertible  into 120,500 shares of 
  OWNED BY                    Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              1,205  shares of Series A Preferred  Stock  convertible  into 120,500 shares of 
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,205 shares of Series A Preferred Stock convertible into 120,500 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           1.1% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           CO
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>


<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   4     OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Management Limited Partnership, a Delaware Limited Partnership ("Canaan Capital
           Management")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Limited  Partnership and Canaan Capital Offshore Limited Partnership C.V.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  1,349  shares of Series A Preferred  Stock  convertible  into 134,900 shares of
  OWNED BY                    Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              1,349  shares of Series A Preferred  Stock  convertible  into 134,900 shares of
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,349 shares of Series A Preferred Stock convertible into 134,900 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           1.2% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   5     OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Offshore Limited Partnership C.V., a Netherlands Antilles Limited Partnership
           ("Canaan Capital Offshore")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital Offshore
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Netherlands Antilles Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                              1,205  shares of Series A Preferred  Stock  convertible  into 120,500 shares of 
                              Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  144 shares of Series A Preferred Stock convertible into 14,400 shares of Common
  OWNED BY                    Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON                     1,205  shares of Series A Preferred  Stock  convertible  into 120,500 shares of 
    WITH                      Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              144 shares of Series A Preferred Stock convertible into 14,400 shares of Common
                              Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,349 shares of Series A Preferred Stock convertible into 134,900 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]



- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           1.2% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D

<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   6     OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Capital Limited Partnership, a Delaware Limited Partnership ("Canaan Capital, L.P.")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Capital, L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                              144 shares of Series A Preferred Stock convertible into 14,400 shares of Common 
                              Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  1,205  shares of Series A Preferred  Stock  convertible  into 120,500 shares of 
  OWNED BY                    Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON                     144 shares of Series A Preferred Stock convertible into 14,400 shares of Common 
    WITH                      Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              1,205  shares of Series A Preferred  Stock  convertible  into 120,500 shares of 
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,349 shares of Series A Preferred Stock convertible into 134,900 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]

- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           1.2% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>
<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   7     OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan S.B.I.C. Partners, L.P., a Delaware Limited Partnership ("Canaan S.B.I.C. Partners")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan S.B.I.C., L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  2,778  shares of Series A Preferred  Stock  convertible  into 277,800 shares of 
  OWNED BY                    Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              2,778  shares of Series A Preferred  Stock  convertible  into 277,800 shares of 
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,778  shares of Series A Preferred  Stock  convertible  into 277,800 shares of Common Stock (See 
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           2.5% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   8     OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan  S.B.I.C.,  L.P.,  a  Delaware  Limited  Partnership  ("Canaan S.B.I.C., L.P.)
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan S.B.I.C., L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                              2,778  shares of Series A Preferred  Stock  convertible  into 277,800 shares of 
                              Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY       
  OWNED BY                    0 shares (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON                     2,778  shares of Series A Preferred  Stock  convertible  into 277,800  shares of 
    WITH                      Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                   
                              0 shares (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,778  shares of Series A Preferred  Stock  convertible  into 277,800 shares of Common Stock (See 
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           2.5% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>
<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   9     OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Venture Partners, L.P., a Delaware Limited Partnership ("Canaan Venture Partners")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture Offshore Limited Partnership, C.V. and Canaan Venture Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  734,693  shares Common Stock and warrants to purchase 3,810 shares of Common 
  OWNED BY                    Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              734,693  shares of Common Stock and warrants to purchase 3,810 shares of
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           734,693 shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           6.9% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D

<CAPTION>

 
- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   10    OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Offshore Management, N.V., a Netherlands Antilles corporation ("Canaan Offshore
           Management")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture Offshore Limited Partnership, C.V.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Netherlands Antilles Corporation
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  517,958  shares Common Stock and warrants to purchase 2,686 shares of Common 
  OWNED BY                    Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              517,958  shares of Common Stock and warrants to purchase 2,686 shares of 
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           517,958 shares of Common Stock and warrants to purchase 2,686 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           4.9% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           CO
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>


<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   11    OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Management Limited Partnership, a Delaware Limited Partnership  ("Canaan Management")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture Offshore Limited Partnership, C.V. and Canaan Venture Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  734,693  shares Common Stock and warrants to purchase 3,810 shares of Common
  OWNED BY                    Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON          
    WITH                      0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              734,693  shares of Common Stock and warrants to purchase 3,810 shares of
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           734,693 shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           6.9% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>
<TABLE>

                                                     SCHEDULE 13D

<CAPTION>
- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   12    OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Venture Offshore Limited Partnership, C.V., a Netherlands Antilles Limited Partnership
           ("Canaan Venture Offshore")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture Offshore
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Netherlands Antilles Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                              517,958  shares of Common Stock and warrants to purchase 2,686 shares of
                              Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  216,735  shares Common Stock and warrants to purchase 1,124 shares of Common 
  OWNED BY                    Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON                     517,958  shares of Common Stock and warrants to purchase 2,686 shares of
    WITH                      Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              216,735  shares of Common Stock and warrants to purchase 1,124 shares of
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           734,693 shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           6.9% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>


<TABLE>

                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE   13    OF   119   PAGES
          ----------------------------------------                                   -------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Canaan Venture Limited Partnership, a Delaware Limited Partnership ("Canaan Venture, L.P.")
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*

           WC of Canaan Venture, L.P.
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware Limited Partnership
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                              216,735  shares of Common Stock and warrants to purchase 1,124 shares of
                              Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  517,958  shares Common Stock and warrants to purchase 2,686 shares of Common 
  OWNED BY                    Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON                     216,735  shares of Common Stock and warrants to purchase 1,124 shares of
    WITH                      Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              517,958  shares of Common Stock and warrants to purchase 2,686 shares of
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           734,693 shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           6.9% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           PN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE    14    OF   119   PAGES
          ----------------------------------------                                   --------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Harry T. Rein
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore, Canaan Capital L.P. and Canaan S.B.I.C., L.P. (with respect to
           Series A Preferred Stock reported in Rows 8 and 10 below) and WC of Canaan Venture Offshore
           and Canaan Venture L.P. (with respect to Common Stock and warrants to purchase Common Stock
           reported in Rows 8 and 10 below)
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
  OWNED BY                    Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase
    EACH                      3,810 shares of Common Stock (See Item 5)
  REPORTING        --------------------------------------------------------------------------------------------------------
   PERSON          9          SOLE DISPOSITIVE POWER
    WITH           
                              0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
                              Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
                              3,810 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           4,127 shares of Series A Preferred Stock convertible into 412,700 shares of Common Stock and
           734,693 shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- --------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           10.3% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D

<CAPTION>

 
- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE    15    OF   119   PAGES
          ----------------------------------------                                   --------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           James J. Fitzpatrick
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore, Canaan Capital L.P. and Canaan S.B.I.C., L.P. (with respect to 
           Series A Preferred Stock reported in Rows 8 and 10 below), WC of Canaan Venture Offshore 
           and Canaan Venture L.P. (with respect to Common Stock and warrants to purchase Common Stock 
           reported in Rows 8 and 10 below) and PF (with respect to Common Stock reported in Rows 7 and 9 below)
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              5,000 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
  OWNED BY                    Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
    EACH                      3,810 shares of Common Stock (See Item 5)
  REPORTING        --------------------------------------------------------------------------------------------------------
   PERSON          9          SOLE DISPOSITIVE POWER
    WITH           
                              5,000 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
                              Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
                              3,810 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           4,127 shares of Series A Preferred Stock convertible into 412,700 shares of Common Stock and
           739,693 shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           10.4% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D

<CAPTION>


- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE    16    OF   119   PAGES
          ----------------------------------------                                   --------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           David C. Fries
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore, Canaan Capital L.P. and Canaan S.B.I.C., L.P. (with respect to
           Series A Preferred Stock reported in Rows 8 and 10 below) and WC of Canaan Venture Offshore
           and Canaan Venture L.P. (with respect to Common Stock and warrants to purchase Common Stock
           reported in Rows 8 and 10 below)
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
  OWNED BY                    Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
    EACH                      3,810 shares of Common Stock (See Item 5)
  REPORTING        --------------------------------------------------------------------------------------------------------
   PERSON          9          SOLE DISPOSITIVE POWER
    WITH           
                              0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
                              Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
                              3,810 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           4,127 shares of Series A Preferred Stock convertible into 412,700 shares of Common Stock and
           734,693 shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           10.3% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D

<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE    17    OF   119   PAGES
          ----------------------------------------                                   --------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Stephen L. Green
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore, Canaan Capital L.P. and Canaan S.B.I.C., L.P. (with respect to
           Series A  Preferred  Stock  reported  in Rows 8 and 10 below)  and PF (with  respect to Series A 
           Preferred  Stock  reported in Rows 7 and 9 below)
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                              40 shares of Series A Preferred Stock  convertible  into 4,000 shares of Common
                              Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  4,127  shares of Series A Preferred  Stock  convertible  into 412,700 shares of
  OWNED BY                    Common Stock (See Item 5)
    EACH           --------------------------------------------------------------------------------------------------------
  REPORTING        9          SOLE DISPOSITIVE POWER
   PERSON                     40 shares of Series A Preferred Stock  convertible  into 4,000 shares of Common 
    WITH                      Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              4,127  shares of Series A Preferred  Stock  convertible  into 412,700 shares of 
                              Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           4,167  shares of Series A Preferred  Stock  convertible  into 416,700 shares of Common Stock (See 
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]

- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           3.7% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D

<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE    18    OF   119   PAGES
          ----------------------------------------                                   --------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Gregory Kopchinsky
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore, Canaan Capital L.P. and Canaan S.B.I.C., L.P. (with respect to
           Series A Preferred Stock reported in Rows 8 and 10 below) and WC of Canaan Venture Offshore
           and Canaan Venture L.P. (with respect to Common Stock and warrants to purchase Common Stock
           reported in Rows 8 and 10 below)
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              0 shares (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
  OWNED BY                    Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
    EACH                      3,810 shares of Common Stock (See Item 5)
  REPORTING        --------------------------------------------------------------------------------------------------------
   PERSON          9          SOLE DISPOSITIVE POWER
    WITH           
                              0 shares (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
                              Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
                              3,810 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           4,127 shares of Series A Preferred Stock convertible into 412,700 shares of Common Stock and
           734,693 shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           10.3% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D

<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE    19    OF   119   PAGES
          ----------------------------------------                                   --------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Robert J. Migliorino
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore, Canaan Capital L.P. and Canaan S.B.I.C., L.P. (with respect to
           Series A  Preferred  Stock  reported  in Rows 8 and 10 below),  WC of Canaan Venture Offshore and
           Canaan Venture L.P. (with respect to Common Stock and warrants to purchase Common Stock
           reported  in Rows 8 and 10 below)  and PF (with  respect  to Series A Preferred Stock reported in 
           Rows 7 and 9 below)
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                              50 shares of Series A Preferred Stock  convertible  into 5,000 shares of Common 
                              Stock and 3,000 shares of Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
  OWNED BY                    Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase
    EACH                      3,810 shares of Common Stock (See Item 5)
  REPORTING        --------------------------------------------------------------------------------------------------------
   PERSON          9          SOLE DISPOSITIVE POWER
    WITH                      50 shares of Series A Preferred Stock  convertible  into 5,000 shares of Common 
                              Stock and 3,000 shares of Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
                              Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
                              3,810 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           4,177 shares of Series A Preferred Stock convertible into 417,700 shares of Common Stock and
           737,693 shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           10.4% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE    20    OF   119   PAGES
          ----------------------------------------                                   --------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Alan E. Salzman
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore, Canaan Capital L.P. and Canaan S.B.I.C., L.P. (with respect to
           Series A  Preferred  Stock  reported  in Rows 8 and 10 below),  WC of Canaan Venture Offshore and
           Canaan Venture L.P. (with respect to Common Stock and warrants to purchase Common Stock
           reported in Rows 8 and 10 below) and PF (with respect to the Series A Preferred Stock and 
           Common Stock reported in Rows 7 and 9 below)
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           Canadian Citizen
- ---------------------------------------------------------------------------------------------------------------------------
                   7          SOLE VOTING POWER
                              200 shares of Series A Preferred Stock convertible into 20,000 shares of Common 
                              Stock, 28,058 shares of Common Stock issuable upon exercise of a stock option, 
                              59,964 shares of Common Stock and 9,523 shares of Common Stock held in trust 
                              for the benefit of Mr. Salzman (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
  OWNED BY                    Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase
    EACH                      3,810 shares of Common Stock (See Item 5)
  REPORTING        --------------------------------------------------------------------------------------------------------
   PERSON          9          SOLE DISPOSITIVE POWER
    WITH                      200 shares of Series A Preferred Stock convertible into 20,000 shares of Common 
                              Stock, 28,058 shares of Common Stock issuable upon exercise of a stock option, 
                              59,964 shares of Common Stock and 9,523 shares of Common Stock held in trust 
                              for the benefit of Mr. Salzman (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
                              Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
                              3,810 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           4,327 shares of Series A Preferred Stock convertible into 432,700 shares of Common Stock and 
           804,180 shares of Common Stock, 28,058 shares of Common Stock issuable upon exercise of a stock 
           option and warrants to purchase 3,810 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           11.3% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>

                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>

<TABLE>
                                                     SCHEDULE 13D
<CAPTION>

- ----------------------------------------------------                          ------------------------------------------------
<S>        <C>                                                                                                       <C>   
CUSIP NO.                              576844 10 4                              PAGE    21    OF   119   PAGES
          ----------------------------------------                                   --------    -------      
- ----------------------------------------------------                          ------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Eric A. Young
- ---------------------------------------------------------------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                                         (a) [ ]
                                                                                                                     (b) [ ]

- ---------------------------------------------------------------------------------------------------------------------------
3          SEC USE ONLY


- ---------------------------------------------------------------------------------------------------------------------------
4          SOURCE OF FUNDS*
           WC of Canaan Capital Offshore, Canaan Capital L.P. and Canaan S.B.I.C., L.P. (with respect to 
           Series A Preferred Stock reported in Rows 8 and 10 below), WC of Canaan Venture Offshore and 
           Canaan Venture L.P. (with respect to Common Stock and warrants reported in Rows 8 and 10 
           below) and PF (with respect to Common Stock reported in Rows 7 and 9 below)
- ---------------------------------------------------------------------------------------------------------------------------
5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)                       [ ]


- ---------------------------------------------------------------------------------------------------------------------------
6          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States Citizen
- ---------------------------------------------------------------------------------------------------------------------------

                   7          SOLE VOTING POWER
                   
                              2,000 shares of Common Stock (See Item 5)
  NUMBER OF        --------------------------------------------------------------------------------------------------------
   SHARES          8          SHARED VOTING POWER
BENEFICIALLY                  4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
  OWNED BY                    Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
    EACH                      3,810 shares of Common Stock (See Item 5)
  REPORTING        --------------------------------------------------------------------------------------------------------
   PERSON          9          SOLE DISPOSITIVE POWER
    WITH           
                              2,000 shares of Common Stock (See Item 5)
                   --------------------------------------------------------------------------------------------------------
                   10         SHARED DISPOSITIVE POWER
                              4,127 shares of Series A Preferred Stock convertible into 412,700 shares of
                              Common  Stock and  734,693  shares of Common  Stock and  warrants  to purchase 
                              3,810 shares of Common Stock (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           4,127 shares of Series A Preferred Stock convertible into 412,700 shares of Common Stock and
           736,693  shares of Common Stock and warrants to purchase 3,810 shares of Common Stock (See 
           Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                                        [ ]


- ---------------------------------------------------------------------------------------------------------------------------
13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           10.3% (See Item 5)
- ---------------------------------------------------------------------------------------------------------------------------
14         TYPE OF REPORTING PERSON*

           IN
- ---------------------------------------------------------------------------------------------------------------------------
<FN>
                                            *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
                            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
</FN>
</TABLE>
<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



ITEM 1.  SECURITY AND ISSUER.

         With respect to the Canaan Capital Funds and Canaan S.B.I.C.  Funds (as
defined below), this Statement on Schedule 13D (the "Statement")  relates to the
common  stock,  par value  $0.01  per  share  (the  "Common  Stock"),  of Matrix
Pharmaceutical,  Inc.,  a Delaware  corporation  (the  "Issuer")  issuable  upon
conversion  of Series A Preferred  Stock  purchased by certain of the  Reporting
Persons on August 26, 1994.  Such Series A Preferred  Stock becomes  convertible
into Common Stock on February 22, 1995. With respect to the Canaan Venture Funds
(as defined below),  the Statement relates to the Common Stock of the Issuer and
this Statement  supersedes  the Schedule 13G  previously  filed by such entities
relating to such Common Stock. The principal executive offices of the Issuer are
located at 1430 O'Brien Drive, Menlo Park, CA 94025.


ITEM 2.  IDENTITY AND BACKGROUND.

         (a)  Pursuant  to  Rules  13d-1(f)(1)  and (2)  promulgated  under  the
Securities  Exchange Act of 1934, as amended (the "Act"), the undersigned hereby
file this Statement on Schedule 13D on behalf of Canaan Capital Partners,  L.P.,
a Delaware  limited  partnership  ("Canaan  Capital  Partners"),  Canaan Capital
Management  Offshore,  N.V., a Netherlands Antilles corporation ("Canaan Capital
Offshore Management"), Canaan Capital Management Limited Partnership, a Delaware
limited  partnership  ("Canaan  Capital  Management"),  Canaan Capital  Offshore
Limited Partnership C.V., a Netherlands  Antilles limited  partnership  ("Canaan
Capital  Offshore"),  Canaan Capital  Limited  Partnership,  a Delaware  limited
partnership ("Canaan Capital L.P.") (collectively, the foregoing are referred to
in Item 1 above as the "Canaan Capital Funds"), Canaan S.B.I.C.  Partners, L.P.,
a Delaware limited partnership  ("Canaan S.B.I.C.  Partners"),  Canaan S.B.I.C.,
L.P., a Delaware limited partnership  ("Canaan S.B.I.C.,  L.P.")  (collectively,
the foregoing are referred to in Item 1 above as the "Canaan  S.B.I.C.  Funds"),
Canaan Venture Partners,  L.P., a Delaware Limited Partnership  ("Canaan Venture
Partners"), Canaan Management Offshore, N.V., a Netherlands Antilles corporation
("Canaan  Offshore  Management"),   Canaan  Management  Limited  Partnership,  a
Delaware  Limited  Partnership  ("Canaan  Management"),  Canaan Venture Offshore
Limited  Partnership,  C.V., a Netherlands Antilles Limited Partnership ("Canaan
Venture  Offshore"),  Canaan Venture  Limited  Partnership,  a Delaware  Limited
Partnership ("Canaan Venture,  L.P.") (collectively,  the foregoing are referred
to in Item 1 above as the  "Canaan  Venture  Funds"),  Harry T.  Rein,  James J.
Fitzpatrick,  David C. Fries,  Stephen L. Green,  Gregory Kopchinsky,  Robert J.
Migliorino, Alan E. Salzman and Eric A. Young, each of whom is a general partner
of Canaan Capital Funds,  Canaan  S.B.I.C.  Funds and Canaan Venture Funds.  The
foregoing  persons are sometimes  hereinafter  referred to  collectively  as the
"Reporting  Persons." The Reporting Persons are making this single, joint filing
because  they may be  deemed to be a  "group"  within  the  meaning  of  Section
13(d)(3)  of the Act,  although  neither  the fact of this  filing nor  anything
contained  herein  shall be deemed to be an  admission  by any of the  Reporting
Persons that such a "group" exists. The convertible Series A Preferred Stock has
been  purchased  by Canaan  Capital  L.P.,  Canaan  Capital  Offshore and Canaan
S.B.I.C., L.P.

                                 Page 22 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D




         CANAAN CAPITAL L.P.

         (b) - (c) Canaan Capital L.P.'s principal  business address (which also
serves as its principal  office) is 105 Rowayton Avenue,  Rowayton,  Connecticut
06853.  Canaan Capital L.P.'s principal business is investment in the securities
of emerging growth companies. The sole general partner of Canaan Capital L.P. is
Canaan Capital  Management,  whose general  partner is Canaan Capital  Partners,
whose  general  partners  and  respective   business   addresses  and  principal
occupations are set forth below.

         CANAAN CAPITAL OFFSHORE

         (b) - (c) Canaan Capital  Offshore's  principal business address (which
also  serves as its  principal  office)  is ABN Trust  Company,  Pietermaai  15,
Curacao,  Netherlands Antilles.  Canaan Capital Offshore's principal business is
investment in the  securities  of emerging  growth  companies.  The sole general
partner of Canaan Capital Offshore is Canaan Capital  Management,  whose general
partner is Canaan  Capital  Partners,  whose  general  partners  and  respective
business addresses and principal occupations are set forth below.

         CANAAN CAPITAL MANAGEMENT

         (b) - (c) Canaan Capital Management's principal business address (which
also  serves  as  its  principal  office)  is  105  Rowayton  Avenue,  Rowayton,
Connecticut 06853. Canaan Capital Management's principal business is to serve as
the general partner of Canaan Capital L.P. and Canaan Capital Offshore. The sole
general partner of Canaan Capital  Management is Canaan Capital Partners,  whose
general  partners  and  their  respective   business   addresses  and  principal
occupations are as set forth below.

         CANAAN CAPITAL OFFSHORE MANAGEMENT

         (b) - (c)  Canaan  Capital  Offshore  Management's  principal  business
address  (which  also  serves as its  principal  office)  is ABN Trust  Company,
Pietermaai  15,  Curacao,   Netherlands   Antilles.   Canaan  Capital   Offshore
Management's  principal  business is to serve as the  general  partner of Canaan
Capital Offshore. The sole general partner of Canaan Capital Offshore Management
is Canaan Capital Partners, whose general partners and their respective business
addresses and principal occupations are as set forth below.

         CANAAN CAPITAL PARTNERS

         (b) - (c) Canaan Capital  Partners'  principal  business address (which
also  serves  as  its  principal  office)  is  105  Rowayton  Avenue,  Rowayton,
Connecticut  06853.  Canaan Capital Partners'  principal business is to serve as
the general partner of Canaan Capital Management. The general partners of Canaan
Capital  Partners  and  their  respective   business   addresses  and  principal
occupations are as follows:


                                 Page 23 of 119
<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D


GENERAL PARTNER                     ADDRESS                      OCCUPATION
- ---------------                     -------                      ----------
                                                         
Harry T. Rein                 105 Rowayton Avenue             General Partner of
                              Rowayton, CT  06853             Canaan Capital
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                         
James J. Fitzpatrick          105 Rowayton Avenue             General Partner of
                              Rowayton, CT  06853             Canaan Capital
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                         
David C. Fries                105 Rowayton Avenue             General Partner of
                              Rowayton, CT  06853             Canaan Capital
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                         
Stephen L. Green              105 Rowayton Avenue             General Partner of
                              Rowayton, CT  06853             Canaan Capital
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                         
Gregory Kopchinsky            105 Rowayton Avenue             General Partner of
                              Rowayton, CT  06853             Canaan Capital
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                         
Robert J. Migliorino          105 Rowayton Avenue             General Partner of
                              Rowayton, CT  06853             Canaan Capital and
                                                              Partners and other
                                                              venture capital
                                                              partnerships
                                                         
Alan E. Salzman               2884 Sand Hill Road             General Partner of
                              Suite 115                       Canaan Capital
                              Menlo Park, CA  94025           Partners and other
                                                              venture capital
                                                              partnerships
                                                        

                                 Page 24 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D


GENERAL PARTNER                     ADDRESS                       OCCUPATION
- ---------------                     -------                       -----------

Eric A. Young                 2884 Sand Hill Road             General Partner of
                              Suite 115                       Canaan Capital
                              Menlo Park, CA  94025           Partners and other
                                                              venture capital
                                                              partnerships

         CANAAN S.B.I.C. L.P.

         (b) - (c) Canaan S.B.I.C. L.P.'s principal business address (which also
serves as its principal  office) is 105 Rowayton Avenue,  Rowayton,  Connecticut
06853. Canaan S.B.I.C. L.P.'s principal business is investment in the securities
of emerging  growth  companies  [classified  as small  businesses  by the United
States  Small  Business  Administration].  The sole  general  partner  of Canaan
S.B.I.C.  L.P. is Canaan  S.B.I.C.  Partners,  whose general  partners and their
respective  business addresses and principal  occupations are as set forth above
for Canaan Capital Partners.

         CANAAN S.B.I.C. PARTNERS

         (b) - (c) Canaan S.B.I.C.  Partners'  principal business address (which
also  serves  as  its  principal  office)  is  105  Rowayton  Avenue,  Rowayton,
Connecticut 06853.  Canaan S.B.I.C.  Partners' principal business is to serve as
the general partner of Canaan S.B.I.C.  L.P.  [classified as small businesses by
the United States Small Business Administration]. The general partners of Canaan
S.B.I.C. Partners are the same as set forth above for Canaan Capital Partners.

         CANAAN VENTURE L.P.

         (b) - (c) Canaan Venture L.P.'s principal  business address (which also
serves as its principal  office) is 105 Rowayton Avenue,  Rowayton,  Connecticut
06853.  Canaan Venture L.P.'s principal business is investment in the securities
of emerging growth companies. The sole general partner of Canaan Venture L.P. is
Canaan  Management,  whose general  partner is Canaan  Venture  Partners,  whose
general  partners  and  their  respective   business   addresses  and  principal
occupations are as set forth above for Canaan Capital Partners.

         CANAAN VENTURE OFFSHORE

         (b) - (c) Canaan Venture  Offshore's  principal business address (which
also  serves as its  principal  office)  is ABN Trust  Company,  Pietermaai  15,
Curacao,  Netherlands Antilles.  Canaan Venture Offshore's principal business is
investment in the  securities  of emerging  growth  companies.  The sole general
partner of Canaan Venture Offshore is Canaan Offshore Management,  whose general
partner is Canaan Venture

                                 Page 25 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                             SCHEDULE 13D



Partners,  whose general  partners and their respective  business  addresses and
principal occupations are as set forth above for Canaan Capital Partners.

         CANAAN MANAGEMENT

         (b) - (c) Canaan  Management's  principal  business address (which also
serves as its principal  office) is 105 Rowayton Avenue,  Rowayton,  Connecticut
06853.  Canaan  Management's  principal business is to serve as the sole general
partner of Canaan  Venture  L.P.  and one of the two general  partners of Canaan
Venture  Offshore.  The general  partner of Canaan Venture  Management is Canaan
Venture Partners, whose general partners and their respective business addresses
and principal occupations are as set forth above for Canaan Capital Partners.

         CANAAN OFFSHORE MANAGEMENT

         (b) - (c)  Canaan  Offshore  Management's  principal  business  address
(which also serves as its principal office) is ABN Trust Company, Pietermaai 15,
Curacao,  Netherlands Antilles.  Canaan Offshore Management's principal business
is to serve as the general partner of Canaan Venture Offshore.  The sole general
partner of Canaan Offshore Management is Canaan Venture Partners,  whose general
partners and their respective  business addresses and principal  occupations are
as set forth above for Canaan Capital Partners.

         CANAAN VENTURE PARTNERS

         (b) - (c) Canaan Venture  Partners'  principal  business address (which
also  serves  as  its  principal  office)  is  105  Rowayton  Avenue,  Rowayton,
Connecticut  06853.  Canaan Venture Partners'  principal business is to serve as
the general partner of Canaan Management. The general partners of Canaan Venture
Partners are the same as set forth above for Canaan Capital Partners.

         (d)  During  the past  five  years,  none of the  entities  or  persons
identified in this Item 2 has been convicted in a criminal proceeding (excluding
traffic violations or similar misdemeanors).

         (e)  During  the past  five  years,  none of the  entities  or  persons
identified  in this Item 2 was a party to a civil  proceeding  of a judicial  or
administrative  body of competent  jurisdiction as a result of which such person
was or is  subject  to a  judgment,  decree  or  final  order  enjoining  future
violations of or prohibiting or mandating  activity  subject to federal or state
securities laws or finding any violation with respect to such laws.

         (f) All of the persons  identified  in this Item 2 are  citizens of the
United States of America except for Alan E. Salzman who is a citizen of Canada.



                                 Page 26 of 119
<PAGE>


CUSIP NO.:  576844 10 4                                             SCHEDULE 13D



ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

         The consideration used in making the purchase of the convertible Series
A Preferred  Stock was obtained  through the working  capital of Canaan  Capital
L.P., Canaan Capital Offshore and Canaan S.B.I.C.,  L.P. The amount of funds was
$129,600, $1,084,500 and $2,500,200, respectively.


ITEM 4.  PURPOSE OF TRANSACTION.

         Canaan Capital L.P., Canaan Capital Offshore and Canaan S.B.I.C.,  L.P.
purchased the convertible  Series A Preferred Stock of the Issuer for investment
purposes.  Such purchases were not made for the purpose of acquiring  control of
the Issuer.  Canaan Capital  Partners and Canaan  S.B.I.C.  Partners may, in the
ordinary course of their role as general partners of Canaan Capital L.P., Canaan
Capital  Offshore and Canaan  S.B.I.C.,  L.P., from time to time,  direct Canaan
Capital  L.P.,  Canaan  Capital  Offshore or Canaan  S.B.I.C.,  L.P., or all, to
purchase  additional  Common  Stock or sell all or a portion of the Common Stock
now held. Pursuant to that certain Investment Agreement,  dated August 26, 1994,
by and between Issuer,  Canaan Capital L.P.,  Canaan Capital Offshore and Canaan
S.B.I.C., L.P. and certain other investors (the "Investment Agreement"),  Canaan
Capital L.P., Canaan Capital Offshore and Canaan S.B.I.C., L.P. were granted S-3
registration rights with respect to the resale of the Common Stock issuable upon
conversion of the Series A Preferred Stock.

         The foregoing  summary of the Investment  Agreement is qualified in its
entirety by reference to the copy of the Investment Agreement attached hereto as
Exhibit 1.

         The  Issuer  filed a  Certificate  of  Designation  of  Preferences  of
Preferred  Shares (the  "Certificate")  with the Delaware  Secretary of State on
August 25, 1994, which Certificate sets forth the exact rights,  preferences and
privileges of the Series A Preferred  Stock and is attached hereto as Exhibit 2.
While each share of Series A Preferred  Stock will become  convertible  into 100
shares of Common Stock on February  22, 1995 (based upon a  conversion  price of
$9.00 per share),  the investors have a one-time  option,  beginning March 1995,
and ending,  but including,  March 1996, to reset the  conversion  price of such
Preferred  Stock to equal the average  closing price of Issuer's Common Stock in
the  event  such   average   closing   price   falls   below  $9.00  per  share.
Notwithstanding the foregoing,  the Certificate provides that the maximum number
of shares each share of Series A Preferred Stock could ultimately be convertible
into is 160  shares  (based  on a  conversion  price of $5.61  per  share).  The
Certificate  also  provides  that the holders of a majority  of the  outstanding
shares  of  Series A  Preferred  Stock,  voting  together  as a class,  shall be
entitled to  designate  one member of the  Issuer's  Board of  Directors at each
annual election of directors.  The Issuer has appointed a representative  of the
Investors to the Issuer's Board of Directors.


                                 Page 27 of 119
<PAGE>


CUSIP NO.:  576844 10 4                                             SCHEDULE 13D



         The foregoing  summary of the  Certificate is qualified in its entirety
by reference to the copy of the Certificate attached hereto as Exhibit 2.

         Except as described in this Item 4, neither Canaan Capital L.P., Canaan
Capital Offshore,  Canaan S.B.I.C.,  L.P. and Canaan Capital and Canaan S.B.I.C.
Partners,  nor, to their best  knowledge,  any of the persons named in Item 2 of
this  Statement,  has  formulated any plans or proposals that relate to or would
result in any of the actions or events  enumerated in clauses (a) through (j) of
Item 4 of Schedule 13D.


ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER.

         I.     CANAAN CAPITAL PARTNERS

         (a)    Amount Beneficially owned: 134,900 
                Percent of Class: 1.2%(1)

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 134,900*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared  power to  dispose  or to  direct  the  disposition:
                    134,900*

                *   As the general partner of Canaan Capital  Management,  which
                    is the general  partner of Canaan  Capital  L.P.  and Canaan
                    Capital  Offshore,  Canaan Capital Partners may be deemed to
                    have shared voting and  disposition  power of the 14,400 and
                    120,500 shares of Common Stock  issuable upon  conversion of
                    the Series A Preferred Stock held by Canaan Capital L.P. and
                    Canaan Capital Offshore.

         (c)    To the best knowledge of Canaan Capital, none of the entities or
                persons listed in Item 2 above has effected any  transactions in
                the Common  Stock other than as described  herein  during the 60
                days prior to December 24, 1994.

         (d)    Canaan  Capital  Partners is the sole general  partner of Canaan
                Capital Offshore Management,  Canaan Capital Management,  Canaan
                Capital  L.P.  and Canaan  Capital  Offshore;  Canaan  Capital's
                general partners are Harry T. Rein, James J. Fitzpatrick,  David
                C. Fries, Stephen L.

- --------
1        Based on 10,729,929  shares of Common Stock outstanding as of September
         30,  1994,  according  to  information  provided  by the  Issuer in its
         Quarterly Report on Form 10-Q.

                                 Page 28 of 119

<PAGE>

CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



                Green, Gregory Kopchinsky, Robert J. Migliorino, Alan E. Salzman
                and Eric A.  Young and  therefore  have the power to direct  the
                affairs of Canaan Capital  Partners,  Canaan Capital  Management
                and thus  Canaan  Capital  L.P.  and  Canaan  Capital  Offshore,
                including  the  decisions  respecting  the  disposition  of  the
                proceeds  from  the  sale of the  Common  Stock.  Under  certain
                circumstances set forth in the limited partnership agreements of
                Canaan  Capital L.P.,  Canaan Capital  Offshore,  Canaan Capital
                Management and Canaan Capital Partners,  the general and limited
                partners  of  such  entities  may  have  the  right  to  receive
                dividends  from,  or the proceeds  from the sale of Common Stock
                owned by each such entity.

         (e)    Not applicable.


         II.    CANAAN CAPITAL OFFSHORE MANAGEMENT

         (a)   Amount Beneficially owned: 120,500 
               Percent of Class: 1.1%

         (b)   Number of shares as to which such person has:

                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 120,500*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared    power   to    dispose    or   to   direct   the
                    disposition:120,500*

                *   As the general  partner of Canaan Capital  Offshore,  Canaan
                    Capital  Offshore  Management  may be deemed to have  shared
                    voting and disposition power of the 120,500 shares of Common
                    Stock  issuable  upon  conversion  of the Series A Preferred
                    Stock held by Canaan Capital Offshore.


         III.   CANAAN CAPITAL MANAGEMENT

         (a)   Amount Beneficially owned: 134,900 
               Percent of Class: 1.2%

         (b)   Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 134,900*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared    power   to    dispose    or   to   direct   the
                    disposition:134,900*

                *   As the general  partner of Canaan  Capital  L.P.  and Canaan
                    Capital Offshore, Canaan Capital Management may be deemed to
                    have shared voting and disposition power of the 14,400 and


                                 Page 29 of 119

<PAGE>

CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



                    120,500 shares of Common Stock  issuable upon  conversion of
                    the Series A Preferred Stock held by Canaan Capital L.P. and
                    Canaan Capital Offshore.

         (c)    See Item 5.I.(c) above.

         (d)    See Item 5.I.(d) above.

         (e)    Not applicable.


         IV.    CANAAN CAPITAL OFFSHORE

         (a)    Amount Beneficially owned: 134,900 
                Percent of Class: 1.2%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: 120,500
                (2) Shared power to vote or to direct vote: 14,400*
                (3) Sole power to dispose or to direct the disposition: 120,500
                (4) Shared  power to  dispose  or to  direct  the  disposition:
                    14,400*

                *   As the general partners of Canaan Capital  Offshore,  Canaan
                    Capital Management and Canaan Capital Partners may be deemed
                    to share  voting  and  disposition  power  over the  120,500
                    shares of  Common  Stock  issuable  upon  conversion  of the
                    Series A Preferred Stock held by Canaan Capital Offshore.

         (c)    See Item 5.I.(c) above.

         (d)    See Item 5.I.(d) above.

         (e)    Not applicable.


         V.     CANAAN CAPITAL L.P.

         (a)    Amount Beneficially owned: 134,900 
                Percent of Class: 1.2%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: 14,400
                (2) Shared power to vote or to direct vote: 120,500*
                (3) Sole power to dispose or to direct the disposition: 14,400
                (4) Shared  power to  dispose  or to  direct  the  disposition:
                    120,500*


                                 Page 30 of 119

<PAGE>

CUSIP NO.:  576844 10 4                                             SCHEDULE 13D



                *   As the  general  partners  of Canaan  Capital  L.P.,  Canaan
                    Capital Management and Canaan Capital Partners may be deemed
                    to share voting and disposition power over the 14,400 shares
                    of Common Stock  issuable  upon  conversion  of the Series A
                    Preferred Stock held by Canaan Capital L.P.

         (c)    See Item 5.I.(c) above.

         (d)    See Item 5.I.(d) above.

         (e)    Not applicable.


         VI.    CANAAN S.B.I.C. PARTNERS

         (a)    Amount Beneficially owned: 277,800 
                Percent of Class: 2.5%

         (b)    Number of shares as to which such person has: 
                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 277,800*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    277,800*

                *   As the sole general partner of Canaan S.B.I.C., L.P., Canaan
                    S.B.I.C.   Partners  may  be  deemed  to  share  voting  and
                    disposition  power over the 277,800  shares of Common  Stock
                    issuable  upon  conversion  of the Series A Preferred  Stock
                    held by Canaan S.B.I.C., L.P.

         (c)    To the best knowledge of Canaan S.B.I.C.  Partners,  none of the
                entities  or  persons  listed in Item 2 above has  effected  any
                transactions in the Common Stock other than as described  herein
                during the 60 days prior to December 24, 1994.

         (d)    Canaan  S.B.I.C.  Partners is the sole general partner of Canaan
                S.B.I.C.,  L.P. Canaan S.B.I.C.  Partner's  general partners are
                Harry T. Rein, James J. Fitzpatrick,  David C. Fries, Stephen L.
                Green, Gregory Kopchinsky, Robert J. Migliorino, Alan E. Salzman
                and Eric A.  Young and  therefore  have the power to direct  the
                affairs of Canaan  S.B.I.C.  Partners and thus Canaan  S.B.I.C.,
                L.P.,  including the decisions respecting the disposition of the
                proceeds  from  the  sale of the  Common  Stock.  Under  certain
                circumstances set forth in the limited partnership agreements of
                Canaan S.B.I.C., L.P. and Canaan S.B.I.C.  Partners, the general
                and limited partners of such entities may have

                                 Page 31 of 119

<PAGE>

CUSIP NO.:  576844 10 4                                             SCHEDULE 13D



                the right to receive  dividends  from,  or the proceeds from the
                sale of Common Stock owned by each such entity.

         (e)    Not applicable.


         VII.   CANAAN S.B.I.C. L.P.

         (a)    Amount Beneficially owned: 277,800 
                Percent of Class: 2.5%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: 277,800
                (2) Shared power to vote or to direct vote: -0-*
                (3) Sole power to dispose or to direct the disposition: 277,800
                (4) Shared power to dispose or to direct the disposition: -0-*

                *   As the sole general partner of Canaan S.B.I.C., L.P., Canaan
                    S.B.I.C.   Partners  may  be  deemed  to  share  voting  and
                    disposition  power over the 277,800  shares of Common  Stock
                    issuable  upon  conversion  of the Series A Preferred  Stock
                    held by Canaan S.B.I.C., L.P.

         (c)    See Item 5.VI.(c) above.

         (d)    See Item 5.VI.(d) above.

         (e)    Not applicable.


         VIII.  CANAAN VENTURE PARTNERS

         (a)    Amount Beneficially owned: 738,503 
                Percent of Class: 6.9%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 738,503*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    738,503*

                *   As the general partner of Canaan Venture  Management,  which
                    is the general  partner of Canaan  Venture  L.P.  and Canaan
                    Venture  Offshore,  Canaan Venture Partners may be deemed to
                    have  shared  voting and  disposition  power of the  517,958
                    shares of Common Stock and warrants to purchase 2,686 shares
                    of Common Stock and 216,735 shares of Common Stock and

                                 Page 32 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



                    warrants to purchase  1,124  shares of Common  Stock held by
                    Canaan   Venture   Offshore   and  Canaan   Venture,   L.P.,
                    respectively.

         (c)    To the best  knowledge of Canaan Venture  Partners,  none of the
                entities  or  persons  listed in Item 2 above has  effected  any
                transactions in the Common Stock other than as described  herein
                during the 60 days prior to December 24, 1994.

         (d)    Canaan  Venture  Partners is the sole general  partner of Canaan
                Offshore Management,  Canaan Venture Management,  Canaan Venture
                L.P.  and Canaan  Venture  Offshore;  Canaan  Venture  Partners'
                general partners are Harry T. Rein, James J. Fitzpatrick,  David
                C.  Fries,  Stephen  L.  Green,  Gregory  Kopchinsky,  Robert J.
                Migliorino, Alan E. Salzman and Eric A. Young and therefore have
                the power to direct  the  affairs  of Canaan  Venture  Partners,
                Canaan Offshore  Management,  Canaan Venture Management and thus
                Canaan Venture L.P. and Canaan Venture  Offshore,  including the
                decisions  respecting  the  disposition of the proceeds from the
                sale of the Common Stock. Under certain  circumstances set forth
                in the limited  partnership  agreements of Canaan  Venture L.P.,
                Canaan Venture  Offshore,  Canaan  Offshore  Management,  Canaan
                Venture Management and Canaan Venture Partners,  the general and
                limited  partners of such entities may have the right to receive
                dividends  from,  or the proceeds  from the sale of Common Stock
                owned by each such entity.

         (e)    Not applicable.


         IX.    CANAAN OFFSHORE MANAGEMENT

         (a)    Amount Beneficially owned: 520,644 
                Percent of Class: 4.9%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 520,644*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    520,644*

                *   As the general  partner of Canaan  Venture,  L.P. and Canaan
                    Venture Offshore,  Canaan Offshore  Management may be deemed
                    to have shared voting and  disposition  power of the 517,958
                    shares of Common Stock and warrants to purchase 2,686 shares
                    of Common  Stock  and  216,735  shares  of Common  Stock and
                    warrants to purchase 1,124 shares of Common Stock

                                 Page 33 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



                    held by Canaan  Venture  Offshore and Canaan  Venture  L.P.,
                    respectively.

         (c)    See Item 5.VII.(c) above.

         (d)    See Item 5.VII.(d) above.

         (e)    Not applicable.


         X.     CANAAN MANAGEMENT

         (a)    Amount Beneficially owned: 738,503 
                Percent of Class: 6.9%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 738,503*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    738,503*

                *   As the general  partner of Canaan  Venture,  L.P. and Canaan
                    Venture  Offshore,  Canaan  Management may be deemed to have
                    shared voting and disposition power of the 517,958 shares of
                    Common Stock and warrants to purchase 2,686 shares of Common
                    Stock and  216,735  shares of Common  Stock and  warrants to
                    purchase 1,124 shares of Common Stock held by Canaan Venture
                    Offshore and Canaan Venture L.P., respectively.

         (c)    See Item 5.VII.(c) above.

         (d)    See Item 5.VII.(d) above.

         (e)    Not applicable.


         XI.    CANAAN VENTURE OFFSHORE

         (a)    Amount Beneficially owned: 738,503 
                Percent of Class: 6.9%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: 520,644
                (2) Shared power to vote or to direct vote: 217,859*
                (3) Sole power to dispose or to direct the disposition: 520,644
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    217,859*

                                 Page 34 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                             SCHEDULE 13D




                *   As the general partners of Canaan Venture  Offshore,  Canaan
                    Management,  Canaan  Offshore  Management and Canaan Venture
                    Partners may be deemed to share voting and disposition power
                    over the  517,958  shares of Common  Stock and  warrants  to
                    purchase 2,686 shares of Common Stock held by Canaan Venture
                    Offshore.

         (c)    See Item 5.VII.(c) above.

         (d)    See Item 5.VII.(d) above.

         (e)    Not applicable.


         XII.   CANAAN VENTURE L.P.

         (a)    Amount Beneficially owned: 738,503 
                Percent of Class: 6.9%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: 217,859
                (2) Shared power to vote or to direct vote: 520,644*
                (3) Sole power to dispose or to direct the disposition: 217,859
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    520,644*

                *   As the  general  partner  of  Canaan  Venture  L.P.,  Canaan
                    Management  and  Canaan  Venture  Partners  may be deemed to
                    share voting and  disposition  power over the 216,735 shares
                    of Common  Stock and  warrants to purchase  1,124  shares of
                    Common Stock held by Canaan Venture L.P.

         (c)    See Item 5.VII.(c) above.

         (d)    See Item 5.VII.(d) above.

         (e)    Not applicable.


         XIII.  Harry T. Rein

         (a)    Amount Beneficially owned: 1,151,203* 
                Percent of Class: 10.3%


                                 Page 35 of 119


<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D


         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 1,151,203*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    1,151,203*

                *   As a general  partner of Canaan Capital  Partners,  the sole
                    general  partner  of  Canaan  Capital  Management,  the sole
                    general  partner  of  Canaan  Capital  Offshore  and  Canaan
                    Capital,  L.P.  and as general  partner  of Canaan  S.B.I.C.
                    Partners, the sole general partner of Canaan S.B.I.C., L.P.,
                    Mr. Rein may be deemed to have shared voting and disposition
                    power of the  120,500,  14,400 and 277,800  shares of Common
                    Stock  issuable  upon  conversion  of the Series A Preferred
                    Stock held by Canaan Capital Offshore,  Canaan Capital, L.P.
                    and Canaan S.B.I.C., L.P., respectively.  Furthermore,  as a
                    general partner of Canaan Venture Partners, the sole general
                    partner of Canaan  Venture  Management  and Canaan  Offshore
                    Management,  the sole  general  partner  of  Canaan  Venture
                    Offshore and Canaan Venture,  Mr. Rein may be deemed to have
                    shared voting and disposition power of the 517,958 shares of
                    Common Stock and warrants to purchase 2,686 shares of Common
                    Stock and  216,735  shares of Common  Stock and  warrants to
                    purchase 1,124 shares of Common Stock held by Canaan Venture
                    Offshore and Canaan Venture L.P., respectively.

         (c)    See Item 5.I.(c), Item 5.VI.(c) and 5.VIII.(c) above.

         (d)    See Item 5.I.(d), Item 5.VI.(d) and 5.VIII.(d) above.

         (e)    Not applicable.


         XIV.   James J. Fitzpatrick

         (a)    Amount Beneficially owned: 1,156,203 
                Percent of Class: 10.4%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: 5,000
                (2) Shared power to vote or to direct vote: 1,151,203*
                (3) Sole power to dispose or to direct the disposition: 5,000
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    1,151,203*


                                 Page 36 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                             SCHEDULE 13D



                *   As a general  partner of Canaan Capital  Partners,  the sole
                    general  partner  of  Canaan  Capital  Management,  the sole
                    general  partner  of  Canaan  Capital  Offshore  and  Canaan
                    Capital,  L.P.  and as general  partner  of Canaan  S.B.I.C.
                    Partners, the sole general partner of Canaan S.B.I.C., L.P.,
                    Mr.  Fitzpatrick  may be deemed to have  shared  voting  and
                    disposition power of the 120,500,  14,400 and 277,800 shares
                    of Common Stock  issuable  upon  conversion  of the Series A
                    Preferred  Stock  held by Canaan  Capital  Offshore,  Canaan
                    Capital,  L.P.  and  Canaan  S.B.I.C.,  L.P.,  respectively.
                    Furthermore,   as  a  general   partner  of  Canaan  Venture
                    Partners,   the  sole  general  partner  of  Canaan  Venture
                    Management and Canaan Offshore Management,  the sole general
                    partner of Canaan Venture  Offshore and Canaan Venture,  Mr.
                    Fitzpatrick   may  be  deemed  to  have  shared  voting  and
                    disposition  power of the 517,958 shares of Common Stock and
                    warrants  to  purchase  2,686  shares  of  Common  Stock and
                    216,735  shares of Common  Stock and  warrants  to  purchase
                    1,124 shares of Common Stock held by Canaan Venture Offshore
                    and Canaan Venture L.P., respectively.

         (c)    See Item 5.I.(c), Item 5.VI.(c) and 5.VIII.(c) above.

         (d)    See Item 5.I.(d), Item 5.VI.(d) and 5.VIII.(d) above.

         (e)    Not applicable.


         XV.    David C. Fries

         (a)    Amount Beneficially owned: 1,151,203 
                Percent of Class: 10.3%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 1,151,203*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    1,151,203*

                *   As a general  partner of Canaan Capital  Partners,  the sole
                    general  partner  of  Canaan  Capital  Management,  the sole
                    general  partner  of  Canaan  Capital  Offshore  and  Canaan
                    Capital,  L.P.  and as general  partner  of Canaan  S.B.I.C.
                    Partners, the sole general partner of Canaan S.B.I.C., L.P.,
                    Dr.   Fries  may  be  deemed  to  have  shared   voting  and
                    disposition power of the 120,500,  14,400 and 277,800 shares
                    of Common

                                 Page 37 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



                    Stock  issuable  upon  conversion  of the Series A Preferred
                    Stock held by Canaan Capital Offshore,  Canaan Capital, L.P.
                    and Canaan S.B.I.C., L.P., respectively.  Furthermore,  as a
                    general partner of Canaan Venture Partners, the sole general
                    partner of Canaan  Venture  Management  and Canaan  Offshore
                    Management,  the sole  general  partner  of  Canaan  Venture
                    Offshore and Canaan Venture, Dr. Fries may be deemed to have
                    shared voting and disposition power of the 517,958 shares of
                    Common Stock and warrants to purchase 2,686 shares of Common
                    Stock and  216,735  shares of Common  Stock and  warrants to
                    purchase 1,124 shares of Common Stock held by Canaan Venture
                    Offshore and Canaan Venture L.P., respectively.

         (c)    See Item 5.I.(c), Item 5.VI.(c) and Item 5.VIII.(c) above.

         (d)    See Item 5.I.(d), Item 5.VI.(d) and Item 5.VIII.(d) above.

         (e)    Not applicable.


         XVI.   Stephen L. Green

         (a)    Amount Beneficially owned: 416,700 
                Percent of Class: 3.7%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: 4,000
                (2) Shared power to vote or to direct vote: 412,700*
                (3) Sole power to dispose or to direct the disposition: 4,000
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    412,700*

                *   As a general  partner of Canaan Capital  Partners,  the sole
                    general  partner  of  Canaan  Capital  Management,  the sole
                    general  partner  of  Canaan  Capital  Offshore  and  Canaan
                    Capital,  L.P.  and as general  partner  of Canaan  S.B.I.C.
                    Partners, the sole general partner of Canaan S.B.I.C., L.P.,
                    Mr.   Green  may  be  deemed  to  have  shared   voting  and
                    disposition power of the 120,500,  14,400 and 277,800 shares
                    of Common Stock  issuable  upon  conversion  of the Series A
                    Preferred  Stock  held by Canaan  Capital  Offshore,  Canaan
                    Capital, L.P. and Canaan S.B.I.C., L.P., respectively.

         (c)    See Item 5.I.(c), Item 5.VI.(c) and Item 5.VIII.(c) above.

         (d)    See Item 5.I.(d), Item 5.VI.(d) and Item 5.VIII.(d) above.

                                 Page 38 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                             SCHEDULE 13D




         (e)    Not applicable.


         XVII.  Gregory Kopchinsky

         (a)    Amount Beneficially owned: 1,151,203
                Percent of Class: 10.3%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: -0-
                (2) Shared power to vote or to direct vote: 1,151,203*
                (3) Sole power to dispose or to direct the disposition: -0-
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    1,151,203*

                *   As a general  partner of Canaan Capital  Partners,  the sole
                    general  partner  of  Canaan  Capital  Management,  the sole
                    general  partner  of  Canaan  Capital  Offshore  and  Canaan
                    Capital,  L.P.  and as general  partner  of Canaan  S.B.I.C.
                    Partners, the sole general partner of Canaan S.B.I.C., L.P.,
                    Mr.  Kopchinsky  may be deemed  to have  shared  voting  and
                    disposition power of the 120,500,  14,400 and 277,800 shares
                    of Common Stock  issuable  upon  conversion  of the Series A
                    Preferred  Stock  held by Canaan  Capital  Offshore,  Canaan
                    Capital,  L.P.  and  Canaan  S.B.I.C.,  L.P.,  respectively.
                    Furthermore,   as  a  general   partner  of  Canaan  Venture
                    Partners,   the  sole  general  partner  of  Canaan  Venture
                    Management and Canaan Offshore Management,  the sole general
                    partner of Canaan Venture  Offshore and Canaan Venture,  Mr.
                    Kopchinsky   may  be  deemed  to  have  shared   voting  and
                    disposition  power of the 517,958 shares of Common Stock and
                    warrants  to  purchase  2,686  shares  of  Common  Stock and
                    216,735  shares of Common  Stock and  warrants  to  purchase
                    1,124 shares of Common Stock held by Canaan Venture Offshore
                    and Canaan Venture L.P., respectively.

         (c)    See Item 5.I.(c), Item 5.VI.(c) and Item 5.VIII.(c) above.

         (d)    See Item 5.I.(d), Item 5.VI.(d) and Item 5.VIII.(d) above.

         (e)    Not applicable.


         XVIII. Robert J. Migliorino

         (a)    Amount Beneficially owned: 1,159,203
                Percent of Class: 10.4%


         Page   39 of 119


<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: 8,000
                (2) Shared power to vote or to direct vote: 1,151,203*
                (3) Sole power to dispose or to direct the disposition: 8,000
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    1,151,203*

                *   As a general  partner of Canaan Capital  Partners,  the sole
                    general  partner  of  Canaan  Capital  Management,  the sole
                    general  partner  of  Canaan  Capital  Offshore  and  Canaan
                    Capital,  L.P.  and as general  partner  of Canaan  S.B.I.C.
                    Partners, the sole general partner of Canaan S.B.I.C., L.P.,
                    Mr.  Migliorino  may be deemed  to have  shared  voting  and
                    disposition power of the 120,500,  14,400 and 277,800 shares
                    of Common Stock  issuable  upon  conversion  of the Series A
                    Preferred  Stock  held by Canaan  Capital  Offshore,  Canaan
                    Capital,  L.P.  and  Canaan  S.B.I.C.,  L.P.,  respectively.
                    Furthermore,   as  a  general   partner  of  Canaan  Venture
                    Partners,   the  sole  general  partner  of  Canaan  Venture
                    Management and Canaan Offshore Management,  the sole general
                    partner of Canaan Venture  Offshore and Canaan Venture,  Mr.
                    Migliorino   may  be  deemed  to  have  shared   voting  and
                    disposition  power of the 517,958 shares of Common Stock and
                    warrants  to  purchase  2,686  shares  of  Common  Stock and
                    216,735  shares of Common  Stock and  warrants  to  purchase
                    1,124 shares of Common Stock held by Canaan Venture Offshore
                    and Canaan Venture L.P., respectively.

         (c)    See Item 5.I.(c), Item 5.VI.(c) and Item 5.VIII.(c) above.

         (d)    See Item 5.I.(d), Item 5.VI.(d) and Item 5.VIII.(d) above.

         (e)    Not applicable.


         XIX.   Alan E. Salzman

         (a)    Amount Beneficially owned: 1,268,748
                Percent of Class: 11.3%

         (b)    Number of shares as to which such person has:
                (1) Sole power to vote or to direct vote: 117,545
                (2) Shared power to vote or to direct vote: 1,151,203*
                (3) Sole power to dispose or to direct the disposition: 117,545
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    1,151,203*


                                 Page 40 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



                *   As a general  partner of Canaan Capital  Partners,  the sole
                    general  partner  of  Canaan  Capital  Management,  the sole
                    general  partner  of  Canaan  Capital  Offshore  and  Canaan
                    Capital,  L.P.  and as general  partner  of Canaan  S.B.I.C.
                    Partners, the sole general partner of Canaan S.B.I.C., L.P.,
                    Mr.  Salzman  may  be  deemed  to  have  shared  voting  and
                    disposition power of the 120,500,  14,400 and 277,800 shares
                    of Common Stock  issuable  upon  conversion  of the Series A
                    Preferred  Stock  held by Canaan  Capital  Offshore,  Canaan
                    Capital,  L.P.  and  Canaan  S.B.I.C.,  L.P.,  respectively.
                    Furthermore,   as  a  general   partner  of  Canaan  Venture
                    Partners,   the  sole  general  partner  of  Canaan  Venture
                    Management and Canaan Offshore Management,  the sole general
                    partner of Canaan Venture  Offshore and Canaan Venture,  Mr.
                    Salzman may be deemed to have shared voting and  disposition
                    power of the 517,958  shares of Common Stock and warrants to
                    purchase  2,686 shares of Common Stock and 216,735 shares of
                    Common Stock and warrants to purchase 1,124 shares of Common
                    Stock held by Canaan  Venture  Offshore  and Canaan  Venture
                    L.P., respectively.

         (c)    See Item 5.I.(c), Item 5.VI.(c) and Item 5.VIII.(c) above.

         (d)    See Item 5.I.(d), Item 5.VI.(d) and Item 5.VIII.(d) above.

         (e)    Not applicable.


         XX.    Eric A. Young

         (a)    Amount Beneficially owned: 1,153,203 
                Percent of Class: 10.3%

         (b)    Number of shares as to which such person has:

                (1) Sole power to vote or to direct vote: 2,000
                (2) Shared power to vote or to direct vote: 1,151,203*
                (3) Sole power to dispose or to direct the disposition: 2,000
                (4) Shared  power  to  dispose  or to  direct  the  disposition:
                    1,151,203*

                *   As a general  partner of Canaan Capital  Partners,  the sole
                    general  partner  of  Canaan  Capital  Management,  the sole
                    general  partner  of  Canaan  Capital  Offshore  and  Canaan
                    Capital,  L.P.  and as general  partner  of Canaan  S.B.I.C.
                    Partners, the sole general partner of Canaan S.B.I.C., L.P.,
                    Mr.   Young  may  be  deemed  to  have  shared   voting  and
                    disposition power of the 120,500,  14,400 and 277,800 shares
                    of

                                 Page 41 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



                    Common  Stock  issuable  upon  conversion  of the  Series  A
                    Preferred  Stock  held by Canaan  Capital  Offshore,  Canaan
                    Capital,  L.P.  and  Canaan  S.B.I.C.,  L.P.,  respectively.
                    Furthermore,   as  a  general   partner  of  Canaan  Venture
                    Partners,   the  sole  general  partner  of  Canaan  Venture
                    Management and Canaan Offshore Management,  the sole general
                    partner of Canaan Venture  Offshore and Canaan Venture,  Mr.
                    Young may be deemed to have  shared  voting and  disposition
                    power of the 517,958  shares of Common Stock and warrants to
                    purchase  2,686 shares of Common Stock and 216,735 shares of
                    Common Stock and warrants to purchase 1,124 shares of Common
                    Stock held by Canaan  Venture  Offshore  and Canaan  Venture
                    L.P., respectively.

         (c)    See Item 5.I.(c), Item 5.VI.(c) and Item 5.VIII.(c) above.

         (d)    See Item 5.I.(d), Item 5.VI.(d) and Item 5.VIII.(d) above.

         (e)    Not applicable.


ITEM 6.  CONTRACTS,  ARRANGEMENTS,  UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT
         TO SECURITIES OF THE ISSUER.

         The  Reporting  Persons  have been granted  certain  rights to register
under the  Securities  Act of 1933,  as amended  (the "1933  Act") the shares of
Common Stock reported  hereon  pursuant to an Amended and Restated  Registration
Rights  Agreement,  dated  August 26, 1994  between the  Issuer,  the  Reporting
Persons, and certain other Investors (the "Investors") (the "Registration Rights
Agreement").

         The Registration  Rights  Agreement gives the Investors,  including the
Reporting Persons,  the right to require one time that the Issuer register under
the 1933 Act  shares  of  Common  Stock  held by the  Investors,  including  the
Reporting  Persons.  Upon the request of the Investors,  including the Reporting
Persons,  the Issuer shall effect a registration  under the 1933 Act on Form S-3
to be filed with the  Securities  and Exchange  Commission  covering the maximum
number of shares of Common  Stock  issuable  on the  conversion  of the Series A
Preferred  Stock,  and shall use its best  efforts  to cause  such  Registration
Statement  to become  effective  within 60 days  (but no  earlier  than 180 days
following August 26, 1994. The Issuer will keep such  Registration  Statement in
effect  until the  earlier of (a) the third  anniversary  of the  closing of the
offering,  (b) such date as all of the shares have been resold, or (c) such time
as all of the shares held by the Investors, including the Reporting Persons, can
be sold within a given 3-month period without  compliance with the  registration
requirement of the 1933 Act pursuant to Rule 144.


                                 Page 42 of 119

<PAGE>


CUSIP NO.:  576844 10 4                                            SCHEDULE 13D



         The foregoing summary of the Registration Rights Agreement is qualified
in its entirety by reference to the copy of the  Registration  Rights  Agreement
attached hereto as Exhibit 3.

         Except  as set forth  herein,  there  are no  contracts,  arrangements,
understandings  or  relationships  (legal or otherwise)  (i) among the Reporting
Persons and, to the best of their  knowledge,  any other persons named in Item 2
above and (ii) between the Reporting Persons or, to the best of their knowledge,
any of the other  persons named in Item 2 above with respect to the Common Stock
of the Issuer.


ITEM 7. MATERIALS TO BE FILED AS EXHIBITS.

         The following documents are filed as exhibits:

         1.   Investment  Agreement,  dated August 26, 1994,  between Issuer and
              Reporting Persons.

         2.   Certificate of  Designation  of  Preferences of Preferred  Shares,
              filed August 25, 1994.

         3.   Registration  Rights  Agreement,  dated  August 26,  1994,  by and
              between Issuer and Reporting Persons.

         4.   Agreement of Joint Filing.

         5.   Power-of-Attorney.


                                 Page 43 of 119

<PAGE>



                                    SIGNATURE



         After reasonable inquiry and to the best of my knowledge and belief,  I
certify that the information  set forth in this Statement is true,  complete and
correct.

Dated:  December __, 1994      CANAAN VENTURE LIMITED PARTNERSHIP

                               By:    Canaan Management Limited Partnership,
                                      Its General Partner

                               By:    Canaan Venture Partners L.P.,
                                      Its General Partner


                               By:
                                      ----------------------------------------
                                      Guy M. Russo
                                      Attorney-in-Fact

                               CANAAN VENTURE OFFSHORE LIMITED
                               PARTNERSHIP, C.V.

                               By:    Canaan Management Limited Partnership,
                                      Its General Partner

                               By:    Canaan Venture Partners L.P.,
                                      Its General Partner


                               By:
                                      ----------------------------------------
                                      Guy M. Russo
                                      Attorney-in-Fact


                               CANAAN MANAGEMENT LIMITED
                               PARTNERSHIP

                               By:    Canaan Venture Partners L.P.,
                                      Its General Partner


                               By:
                                      ----------------------------------------
                                      Guy M. Russo
                                      Attorney-in-Fact


                                 Page 44 of 119

<PAGE>




                        CANAAN OFFSHORE MANAGEMENT, N.V.


                        By:
                              President


                        CANAAN VENTURE PARTNERS L.P.


                        By:
                              ------------------------------------------
                              Attorney-in-Fact


                        CANAAN CAPITAL LIMITED PARTNERSHIP

                        By:   Canaan Capital Management Limited
                              Partnership, General Partner

                        By:   Canaan Capital Partners L.P., General Partner


                        By:
                              ------------------------------------------
                              Guy M. Russo
                              Attorney-in-Fact


                        CANAAN CAPITAL OFFSHORE LIMITED
                        PARTNERSHIP C.V.

                        By:   Canaan Capital Management Limited
                              Partnership, General Partner

                        By:   Canaan Capital Partners L.P., General Partner


                        By:
                              ------------------------------------------
                              Guy M. Russo
                              Attorney-in-Fact



                                 Page 45 of 119

<PAGE>



                       CANAAN CAPITAL MANAGEMENT LIMITED
                       PARTNERSHIP

                       By:   Canaan Capital Partners L.P., General Partner


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact


                       CANAAN CAPITAL PARTNERS L.P.


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact


                       CANAAN S.B.I.C., L.P.

                       By:   Canaan S.B.I.C. Partners, L.P., General Partner


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact


                       CANAAN S.B.I.C. PARTNERS, L.P.


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact



                                 Page 46 of 119

<PAGE>



                         HARRY T. REIN
                         JAMES J. FITZPATRICK
                         DAVID C. FRIES
                         STEPHEN L. GREEN
                         GREGORY KOPCHINSKY
                         ROBERT J. MIGLIORINO
                         ALAN E. SALZMAN
                         ERIC A. YOUNG


                         By:   
                               ------------------------------------------
                               Guy M. Russo
                               Attorney-in-Fact


                                 Page 47 of 119

<PAGE>



                                  EXHIBIT INDEX


                                                                            PAGE
                                                                            ----

1.       Investment Agreement, dated August 26, 1994, by and between        
         Issuer and Reporting Persons.                                       49

2.       Certificate of Designation of Preferences of Preferred Shares,
         filed August 25, 1994.                                              72

3.       Registration Rights Agreement, dated August 26, 1994, by and
         between Issuer and Reporting Persons.                               80

4.       Agreement of Joint Filing.                                         103

5.       Power-of-Attorney.                                                 107




                                 Page 48 of 119

<PAGE>



                                    EXHIBIT 2

                                             
                           Agreement of Joint Filing



                  The  undersigned  hereby agree that a single  Schedule 13D (or
any amendment thereto) relating to Common Stock of Matrix  Pharmaceutical,  Inc.
shall be filed on behalf  of each of the  undersigned  and that  this  Agreement
shall be filed as an Exhibit to such Schedule 13D.

                  This Agreement and the filing of the Schedule 13D shall not be
construed  to be an  admission  that any of the  undersigned  is a  member  of a
"group" consisting of one or more of such persons pursuant to Section 13d of the
Securities Exchange Act of 1934, as amended, and the rules thereunder.

Date:  December __, 1994    CANAAN VENTURE LIMITED PARTNERSHIP

                            By:   Canaan Management Limited Partnership,
                                  Its General Partner

                            By:   Canaan Venture Partners L.P.,
                                  Its General Partner


                            By:
                                  ------------------------------------------
                                  Guy M. Russo
                                  Attorney-in-Fact

                            CANAAN VENTURE OFFSHORE LIMITED
                            PARTNERSHIP, C.V.

                            By:   Canaan Management Limited Partnership,
                                  Its General Partner

                            By:   Canaan Venture Partners L.P.,
                                  Its General Partner


                            By:
                                  ------------------------------------------
                                  Guy M. Russo
                                  Attorney-in-Fact



                                 Page 49 of 119

<PAGE>



                         CANAAN MANAGEMENT LIMITED
                         PARTNERSHIP

                         By:   Canaan Venture Partners L.P.,
                               Its General Partner


                         By:
                               ------------------------------------------
                               Guy M. Russo
                               Attorney-in-Fact


                         CANAAN OFFSHORE MANAGEMENT, N.V.


                         By:
                               ------------------------------------------
                               President


                         CANAAN VENTURE PARTNERS L.P.


                         By:
                               ------------------------------------------
                               Attorney-in-Fact


                         CANAAN CAPITAL LIMITED PARTNERSHIP

                         By:   Canaan Capital Management Limited
                               Partnership, General Partner

                         By:   Canaan Capital Partners L.P., General Partner


                         By:
                               ------------------------------------------
                               Guy M. Russo
                               Attorney-in-Fact



                                 Page 50 of 119

<PAGE>



                       CANAAN CAPITAL OFFSHORE LIMITED
                       PARTNERSHIP C.V.

                       By:   Canaan Capital Management Limited
                             Partnership, General Partner

                       By:   Canaan Capital Partners L.P., General Partner


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact


                       CANAAN CAPITAL MANAGEMENT LIMITED
                       PARTNERSHIP

                       By:   Canaan Capital Partners L.P., General Partner


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact


                       CANAAN CAPITAL PARTNERS L.P.


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact


                       CANAAN S.B.I.C., L.P.

                       By:   Canaan S.B.I.C. Partners, L.P., General Partner


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact



                                 Page 51 of 119

<PAGE>


                       CANAAN S.B.I.C. PARTNERS, L.P.


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact


                       HARRY T. REIN
                       JAMES J. FITZPATRICK
                       DAVID C. FRIES
                       STEPHEN L. GREEN
                       GREGORY KOPCHINSKY
                       ROBERT J. MIGLIORINO
                       ALAN E. SALZMAN
                       ERIC A. YOUNG


                       By:
                             ------------------------------------------
                             Guy M. Russo
                             Attorney-in-Fact


                                 Page 52 of 119



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