MATRIX PHARMACEUTICAL INC/DE
S-8, 1997-07-28
PHARMACEUTICAL PREPARATIONS
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      As filed with the Securities and Exchange Commission on July 28, 1997
                                                      Registration No. 333-_____
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                ----------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      Under
                           The Securities Act of 1933
                                ----------------

                           MATRIX PHARMACEUTICAL, INC.
             (Exact name of registrant as specified in its charter)

          Delaware                                        94-2957068
 (State or other jurisdiction                  (IRS Employer Identification No.)
of incorporation or organization)

                               34700 Campus Drive
                            Fremont, California 94555
               (Address of principal executive offices) (Zip Code)

                                ----------------

                           MATRIX PHARMACEUTICAL, INC.
                           1988 RESTRICTED STOCK PLAN
                        1991 DIRECTORS STOCK OPTION PLAN
                           (Full titles of the Plans)

                                ----------------

                                 James R. Glynn
               Chief Operating Officer and Chief Financial Officer
                           Matrix Pharmaceutical, Inc.
                      34700 Campus Drive, Fremont, CA 94555
                     (Name and address of agent for service)
                                 (510) 742-9900
          (Telephone number, including area code, of agent for service)

                                ----------------

<TABLE>
                         CALCULATION OF REGISTRATION FEE
<CAPTION>
                                                                   Proposed          Proposed
                                                                    Maximum           Maximum
                                         Amount to be            Offering Price   Aggregate Offering          Amount of
Title of Securities to be Registered     Registered(1)            per Share(2)         Price(2)            Registration Fee
====================================================================================================================================
<S>                                     <C>                         <C>             <C>                     <C>
1988 Restricted Stock Plan
Common Stock, $0.01 par value           2,000,000 shares            $6.28125        $12,562,500.00          $3,806.82

1991 Directors Stock Option Plan
Common Stock, $0.01 par value             250,000 shares            $6.28125        $ 1,570,312.50          $  475.85

====================================================================================================================================
<FN>
(1)  This  Registration  Statement  shall  also cover any  additional  shares of
     Common Stock which become  issuable  under the 1988  Restricted  Stock Plan
     and/or  the  1991  Directors  Stock  Option  Plan by  reason  of any  stock
     dividend,  stock  split,  recapitalization  or  other  similar  transaction
     effected without the receipt of consideration  which results in an increase
     in the  number of the  outstanding  shares of Matrix  Pharmaceutical,  Inc.
     Common Stock.

(2)  Calculated  solely for purposes of this  offering  under Rule 457(h) of the
     Securities  Act of 1933,  as amended,  (the "1933 Act") on the basis of the
     average of the high and low  selling  prices  per share of Common  Stock of
     Matrix  Pharmaceutical,  Inc.  on July 23,  1997 as  reported by the Nasdaq
     National Market.
</FN>
</TABLE>

<PAGE>


                                     PART II

               Information Required in the Registration Statement


Item 3.  Incorporation of Certain Documents by Reference

     Matrix  Pharmaceutical,  Inc. (the  "Registrant")  hereby  incorporates  by
reference into this Registration  Statement the following  documents  previously
filed with the Securities and Exchange Commission (the "Commission"):

     (a)       The  Registrant's  Annual Report on Form 10-K for the fiscal year
               ended  December 31, 1996,  filed with the Commission on March 25,
               1997  pursuant to Section 13 of the  Securities  Exchange  Act of
               1934, as amended (the "Exchange Act");

     (b)       The  Registrant's  Quarterly  Report on Form 10-Q for the  fiscal
               quarter  ended March 31, 1997,  filed with the  Commission on May
               12, 1997 pursuant to Section 13 of the Exchange Act;

     (c)       The Registrant's  Registration  Statement No. 0-19750 on Form 8-A
               filed  with the  Commission  December  19,  1991,  together  with
               Amendments  No. 1 and No. 2 on Form 8 filed  January 23, 1992 and
               January 27, 1992,  respectively,  in which there is described the
               terms,  rights  and  provisions  applicable  to the  Registrant's
               outstanding Common Stock.

     All reports and definitive  proxy or information  statements filed pursuant
to Section 13(a),  13(c), 14 or 15(d) of the Exchange Act after the date of this
Registration  Statement  and prior to the filing of a  post-effective  amendment
which  indicates  that all  securities  offered  hereby  have been sold or which
deregisters  all  securities  then  remaining  unsold  shall  be  deemed  to  be
incorporated  by reference  into this  Registration  Statement  and to be a part
hereof from the date of filing of such documents.  Any statement  contained in a
document  incorporated or deemed to be incorporated by reference herein shall be
deemed to be modified or superseded for purposes of this Registration  Statement
to the extent that a statement  contained  herein or in any  subsequently  filed
document which is also deemed to be incorporated by reference herein modifies or
supersedes  such statement.  Any such statement so modified or superseded  shall
not be deemed, except as so modified or superseded, to constitute a part of this
Registration Statement.

Item 4.  Description of Securities

     Not applicable.

Item 5.  Interests of Named Experts and Counsel

     Not applicable.

Item 6.  Indemnification of Directors and Officers

     Pursuant to the  Delaware  General  Corporation  Law,  the  Registrant  has
adopted provisions in its Restated  Certificate of Incorporation which eliminate
the personal  liability of its directors and officers to the  Registrant and its
stockholders  for  monetary  damages  for  breach of their  fiduciary  duties in
certain  circumstances  and which  authorize  the  Registrant  to indemnify  its
directors, officers and other agents, by bylaw, agreement or otherwise,


<PAGE>


to the fullest  extent  permitted by law. The  Registrant's  Bylaws  require the
Registrant to indemnify its directors,  officers,  employees and other agents to
the fullest extent permitted by law.

     The Registrant's Restated Certificate of Incorporation and Bylaws expressly
authorize the use of  indemnification  agreements  and, with the approval of its
stockholders,   the  Registrant   has  entered  into  separate   Indemnification
Agreements with its directors and certain of its officers. These Indemnification
Agreements  may  require  the  Registrant,  among  other  things,  to  indemnify
directors and officers  against certain  liabilities that may arise by reason of
their status or service as directors and officers and to advance their  expenses
incurred as a result of any  proceeding  against  them as to which they could be
indemnified. The Registrant maintains an insurance policy covering directors and
officers,  under  which the  insurer  has  agreed  to pay,  subject  to  certain
exclusions  (including  certain  violations  of  securities  laws) the amount of
insured claims made against the insured officers and directors of the Registrant
for wrongful  acts that such  officers or directors may otherwise be required to
pay or for which the  Registrant  is required to  indemnify  such  officers  and
directors.

Item 7.  Exemption from Registration Claimed

     Not applicable.

Item 8.  Exhibits

 Exhibit Number       Exhibit
- ----------------     ----------
     4.0             Instruments  Defining Rights of Stockholders.  Reference is
                     made to Registrant's  Registration Statement No. 0-19750 on
                     Form 8-A which is incorporated herein by reference pursuant
                     to Item 3(c).
     5.1             Opinion of Brobeck, Phleger & Harrison LLP.
    23.1             Consent of Ernst & Young LLP, Independent Auditors.
    23.2             Consent of Brobeck,  Phleger & Harrison LLP is contained in
                     Exhibit 5.1.
    24               Power of  Attorney.  Reference is made to page II-4 of this
                     Registration Statement.
    99.1             1988  Restricted  Stock Plan (Amended and Restated  through
                     March 19, 1997).
    99.2             Form  Stock  Option   Agreement  with  Notice  of  Grant  -
                     Installment  Option  (incorporated  by reference to Exhibit
                     99.2 of Registration Statement No. 33-79908).
    99.3             Form of  Stock  Option  Agreement  with  Notice  of Grant -
                     Immediately  Exercisable Option  (incorporated by reference
                     to Exhibit 28.2 of Registration Statement No. 33-65542).
    99.4             Form of Stock Purchase Agreement (incorporated by reference
                     to Exhibit 28.3 of Registration Statement No. 33-65542).
    99.5             Form of Restricted Stock Purchase  Agreement  (incorporated
                     by reference to Exhibit 28.4 of Registration  Statement No.
                     33-65542).
    99.6             Form  of  Stock  Issuance  Agreement  -  Shared  Investment
                     Program.
    99.7             1991  Directors  Stock  Option Plan  (Amended  and Restated
                     through March 19, 1997).
    99.8             Form of  Non-Statutory  Stock Option  Agreement  (Automatic
                     Option Grant).
    99.9             Form  of  Special   40,000-share   Automatic  Option  Grant
                     (incorporated  by reference to Exhibit 99.2 of Registration
                     Statement No. 33-93476).


Item 9. Undertakings

     A. The undersigned  Registrant hereby  undertakes:  (1) to file, during any
period in which  offers or sales are being made, a  post-effective  amendment to
this Registration Statement (i) to include any prospectus

                                      II-2

<PAGE>


required by Section  10(a)(3) of the 1933 Act, (ii) to reflect in the prospectus
any  facts or  events  arising  after the  effective  date of this  Registration
Statement  (or  the  most  recent   post-effective   amendment  thereof)  which,
individually  or in  the  aggregate,  represent  a  fundamental  change  in  the
information set forth in this Registration  Statement,  and (iii) to include any
material  information  with respect to the plan of  distribution  not previously
disclosed  in  this  Registration  Statement  or any  material  change  to  such
information in this  Registration  Statement;  provided,  however,  that clauses
(1)(i) and (1)(ii) shall not apply if the information required to be included in
a post-effective  amendment by those paragraphs is contained in periodic reports
filed by the Registrant  pursuant to Section 13 or Section 15(d) of the Exchange
Act that are  incorporated by reference into this  Registration  Statement;  (2)
that for the purpose of determining  any liability  under the 1933 Act each such
post-effective  amendment  shall be  deemed to be a new  registration  statement
relating to the securities  offered  therein and the offering of such securities
at that time shall be deemed to be the initial bona fide offering  thereof;  and
(3) to remove from  registration by means of a  post-effective  amendment any of
the securities  being  registered  which remain unsold at the termination of the
Registrant's 1988 Restricted Stock Plan and/or 1991 Directors Stock Option Plan.

     B. The  undersigned  Registrant  hereby  undertakes  that,  for purposes of
determining  any liability  under the 1933 Act, each filing of the  Registrant's
annual  report  pursuant to Section  13(a) or Section  15(d) of the Exchange Act
that is  incorporated  by reference into this  Registration  Statement  shall be
deemed to be a new  registration  statement  relating to the securities  offered
therein,  and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.

     C. Insofar as  indemnification  for liabilities  arising under the 1933 Act
may be permitted to directors, officers or controlling persons of the Registrant
pursuant to the indemnity  provisions  summarized  in Item 6 or  otherwise,  the
Registrant  has  been  informed  that  in the  opinion  of the  Commission  such
indemnification  is against  public  policy as expressed in the 1933 Act and is,
therefore,  unenforceable. In the event that a claim for indemnification against
such liabilities  (other than the payment by the Registrant of expenses incurred
or paid by a director,  officer or  controlling  person of the Registrant in the
successful  defense of any  action,  suit or  proceeding)  is  asserted  by such
director,  officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy  as  expressed  in the  1933  Act  and  will  be  governed  by the  final
adjudication of such issue.

                                      II-3

<PAGE>


                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, as amended, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the City of Fremont,  State of  California,  on this 25th day of
July, 1997.

                                              MATRIX PHARMACEUTICAL, INC.


                                              By  /s/ JAMES R. GLYNN
                                                --------------------------------
                                                James R. Glynn
                                                Chief Operating Officer

                                POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS:

     That the undersigned officer and directors of Matrix Pharmaceutical,  Inc.,
a Delaware  corporation,  do hereby  constitute  and appoint  James R. Glynn the
lawful attorney and agent,  with full power and authority to do any and all acts
and things and to execute any and all instruments  which said attorney and agent
determines may be necessary or advisable or required to enable said  corporation
to  comply  with  the  Securities  Act of 1933,  as  amended,  and any  rules or
regulations  or  requirements  of the  Securities  and  Exchange  Commission  in
connection with this Registration Statement.  Without limiting the generality of
the foregoing  power and  authority,  the powers  granted  include the power and
authority  to sign the names of the  undersigned  officer and  directors  in the
capacities  indicated  below  to  this  Registration  Statement,  to any and all
amendments,  both  pre-effective  and  post-effective,  and  supplements to this
Registration  Statement,  and to any and all  instruments or documents  filed as
part of or in  conjunction  with this  Registration  Statement or  amendments or
supplements  thereof,  and each of the undersigned  hereby ratifies and confirms
all that said attorney and agent shall do or cause to be done by virtue  hereof.
This Power of Attorney may be signed in several counterparts.

     IN WITNESS  WHEREOF,  each of the  undersigned  has executed  this Power of
Attorney as of the date indicated.

<TABLE>
     Pursuant to the  requirements  of the  Securities  Act of 1933, as amended,
this  Registration  Statement has been signed below by the following  persons in
the capacities and on the dates indicated.

<CAPTION>
Signatures                            Title                                           Date
- ----------                            -----                                           ----

<S>                                   <C>                                             <C>
 /s/ JAMES R. GLYNN                   Chief Operating Officer, Chief Financial        July 25, 1997
- --------------------------------      Officer and Director
James R. Glynn                        (Principal Executive and Financial Officer)


 /s/ EDWARD E. LUCK                   Chairman of the Board                           July 25, 1997
- --------------------------------
Edward E. Luck

                                      II-4

<PAGE>


Signatures                            Title                                           Date
- ----------                            -----                                           ----


 /s/ J. STEPHAN DOLEZALEK             Director                                        July 25, 1997
- --------------------------------
J. Stephan Dolezalek


                                      Director                                        July   , 1997
- --------------------------------
John E. Lyons


 /s/ JULIUS L. PERICOLA               Director                                        July 25, 1997
- --------------------------------
Julius L. Pericola


 /s/ ALAN E. SALZMAN                  Director                                        July 25, 1997
- --------------------------------
Alan E. Salzman
</TABLE>

                                      II-5

<PAGE>


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    EXHIBITS

                                       TO

                                    FORM S-8

                                      UNDER

                             SECURITIES ACT OF 1933


                           MATRIX PHARMACEUTICAL, INC.




<PAGE>



                                  EXHIBIT INDEX


Exhibit Number        Exhibit
- --------------       ---------
     4.0             Instruments  Defining Rights of Stockholders.  Reference is
                     made to Registrant's  Registration Statement No. 0-19750 on
                     Form 8-A which is incorporated herein by reference pursuant
                     to Item 3(c).
     5.1             Opinion of Brobeck, Phleger & Harrison LLP.
    23.1             Consent of Ernst & Young LLP, Independent Auditors.
    23.2             Consent of Brobeck,  Phleger & Harrison LLP is contained in
                     Exhibit 5.1.
    24               Power of  Attorney.  Reference is made to page II-4 of this
                     Registration Statement.
    99.1             1988  Restricted  Stock Plan (Amended and Restated  through
                     March 19, 1997).
    99.2             Form  Stock  Option   Agreement  with  Notice  of  Grant  -
                     Installment  Option  (incorporated  by reference to Exhibit
                     99.2 of Registration Statement No. 33-79908).
    99.3             Form of  Stock  Option  Agreement  with  Notice  of Grant -
                     Immediately  Exercisable Option  (incorporated by reference
                     to Exhibit 28.2 of Registration Statement No. 33-65542).
    99.4             Form of Stock Purchase Agreement (incorporated by reference
                     to Exhibit 28.3 of Registration Statement No. 33-65542).
    99.5             Form of Restricted Stock Purchase  Agreement  (incorporated
                     by reference to Exhibit 28.4 of Registration  Statement No.
                     33-65542).
    99.6             Form  of  Stock  Issuance  Agreement  -  Shared  Investment
                     Program.
    99.7             1991  Directors  Stock  Option Plan  (Amended  and Restated
                     through March 19, 1997).
    99.8             Form of  Non-Statutory  Stock Option  Agreement  (Automatic
                     Option Grant).
    99.9             Form  of  Special   40,000-share   Automatic  Option  Grant
                     (incorporated  by reference to Exhibit 99.2 of Registration
                     Statement No. 33-93476).





                                   Exhibit 5.1

<PAGE>

                                                                     Exhibit 5.1

                                  July 25, 1997






Matrix Pharmaceutical, Inc.
34700 Campus Drive
Fremont, California  94555


     Re:    Matrix  Pharmaceutical,  Inc.
            Registration Statement of an Aggregate of 2,250,000 Shares of
            Common Stock


Gentlemen:

     We  refer to your  Registration  Statement  on Form S-8 (the  "Registration
Statement")  under the  Securities  Act of 1933, as amended,  of (i) Two Million
(2,000,000)  shares of common stock ("Common  Stock") of Matrix  Pharmaceutical,
Inc. (the "Company") issuable under the Company's 1988 Restricted Stock Plan, as
amended and restated, (the "Plan") and (ii) Two Hundred Fifty Thousand (250,000)
shares of Common Stock issuable under the Company's 1991 Directors  Stock Option
Plan (the  "Directors  Plan").  We advise you that,  in our  opinion,  when such
shares have been issued and sold  pursuant to the  applicable  provisions of the
Plan  and/or  the  Directors  Plan  and  in  accordance  with  the  Registration
Statement,  such shares will be validly  issued,  fully paid and  non-assessable
shares of the Company's Common Stock.

     We hereby  consent  to the  filing of this  opinion  as an  exhibit  to the
Registration Statement.


                                            Very truly yours,


                                            /s/ BROBECK, PHLEGER & HARRISON
                                            BROBECK, PHLEGER & HARRISON LLP




                                  Exhibit 23.1

<PAGE>


                                                                    Exhibit 23.1


               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


     We consent to the incorporation by reference in the Registration  Statement
(Form S-8) pertaining to the Matrix  Pharmaceutical,  Inc. 1988 Restricted Stock
Plan and the 1991  Directors  Stock Option Plan of our report dated  January 28,
1997,  with  respect  to  the  consolidated   financial  statements  for  Matrix
Pharmaceutical,  Inc.  included  in the Annual  Report  (Form 10-K) for the year
ended December 31, 1996, filed with the Securities and Exchange Commission.


                                                               ERNST & YOUNG LLP


Palo Alto, California
July 24, 1997




                                  Exhibit 99.1

<PAGE>

                           MATRIX PHARMACEUTICAL, INC.

                           1988 RESTRICTED STOCK PLAN

                AS AMENDED AND RESTATED EFFECTIVE MARCH 19, 1997


<PAGE>


                                TABLE OF CONTENTS



                                                                            Page

ARTICLE I....................................................................  1
   GENERAL...................................................................  1
            1.       PURPOSE OF THE PLAN.....................................  1
            2.       STRUCTURE OF THE PLAN...................................  2
            3.       ADMINISTRATION OF THE PLAN..............................  2
            4.       OPTION GRANTS AND SHARE ISSUANCES.......................  2
            5.       STOCK SUBJECT TO THE PLAN...............................  3
ARTICLE II...................................................................  5
   OPTION GRANT PROGRAM......................................................  5
            1.       TERMS AND CONDITIONS OF OPTIONS.........................  5
            2.       INCENTIVE OPTIONS.......................................  9
            3.       STOCK APPRECIATION RIGHTS............................... 10
            4.       CORPORATE TRANSACTION................................... 11
            5.       CANCELLATION AND NEW GRANT OF OPTIONS................... 12
            6.       EXTENSION OF EXERCISE PERIOD............................ 13
ARTICLE III.................................................................. 14
   STOCK ISSUANCE PROGRAM.................................................... 14
            1.       TERMS AND CONDITIONS OF STOCK ISSUANCES................. 14
            2.       CORPORATE TRANSACTION................................... 16
ARTICLE IV................................................................... 17
   MISCELLANEOUS............................................................. 17
            1.       LOANS OR INSTALLMENT PAYMENTS .......................... 17
            2.       AMENDMENT OF THE PLAN AND AWARDS........................ 17
            3.       EFFECTIVE DATE AND TERM OF PLAN......................... 18
            4.       USE OF PROCEEDS......................................... 20
            5.       WITHHOLDING............................................. 20
            6.       REGULATORY APPROVALS.................................... 20
            7.       NO EMPLOYMENT/SERVICE RIGHTS ........................... 21

SPECIAL ADDENDUM.............................................................A-1


<PAGE>


                          MATRIX PHARMACEUTICAL, INC.
                           1988 RESTRICTED STOCK PLAN

                (As Amended and Restated Through March 19, 1997)


                                    ARTICLE I


     GENERAL

     1.  PURPOSE OF THE PLAN

         (a) This 1988 Restricted Stock Plan (the "Plan") is intended to promote
the  interests  of Matrix  Pharmaceutical,  Inc.,  a Delaware  corporation  (the
"Corporation"),  by providing  incentives to eligible  individuals  to acquire a
proprietary  interest,  or otherwise increase their proprietary interest, in the
Corporation  and to remain in the employ or service of the  Corporation  (or its
parent or subsidiary corporations).

         (b) For  purposes  of the  Plan,  the  following  provisions  shall  be
applicable  in  determining  the  parent  and  subsidiary  corporations  of  the
Corporation:

               (i) Any corporation  (other than the  Corporation) in an unbroken
     chain of corporations ending with the Corporation shall be considered to be
     a parent corporation of the Corporation,  provided each such corporation in
     the unbroken  chain (other than the  Corporation)  owns, at the time of the
     determination,  stock  possessing  fifty percent (50%) or more of the total
     combined  voting  power  of all  classes  of  stock  in  one  of the  other
     corporations in such chain.

               (ii) Each corporation (other than the Corporation) in an unbroken
     chain of corporations beginning with the Corporation shall be considered to
     be a subsidiary of the Corporation,  provided each such corporation  (other
     than the last  corporation)  in the unbroken chain owns, at the time of the
     determination,  stock  possessing  fifty percent (50%) or more of the total
     combined  voting  power  of all  classes  of  stock  in  one  of the  other
     corporations in such chain.


<PAGE>


     2.  STRUCTURE OF THE PLAN

         The Plan  shall be divided  into two  separate  components:  the Option
Grant Program  specified in Article II and the Stock Issuance Program  specified
in Article III.  Under the Option Grant  Program,  eligible  individuals  may be
granted  options  to  purchase  shares of the  Corporation's  Common  Stock at a
discount of up to 15% of the fair market value of such shares on the grant date.

         The Stock Issuance Program will allow eligible  individuals to purchase
shares of the Corporation's Common Stock at discounts from the fair market value
of such shares of up to 15%. Such shares may be issued as fully-vested shares or
as shares to vest over time.  Issuances may be effected  either  through  direct
purchases or through the exercise of intervening option grants.

         Unless the context  clearly  indicates  otherwise,  the  provisions  of
Articles I and IV of the Plan shall apply to both the Option  Grant  Program and
the Stock  Issuance  Program and shall  accordingly  govern the interests of all
individuals in the Plan.

     3.  ADMINISTRATION OF THE PLAN

         (a) The Plan shall be administered by a committee  ("Committee") of two
(2) or more members of the  Corporation's  Board of  Directors  appointed by the
Board. Members of the Committee shall serve for such period of time as the Board
may determine and shall be subject to removal by the Board at any time.

         (b) The  Committee  as Plan  Administrator  shall  have full  power and
authority  (subject to the express  provisions  of the Plan) to  establish  such
rules and regulations as it may deem  appropriate for the proper  administration
of the Plan and to make such  determinations  under the Plan and any outstanding
option  grants  or  share  issuances  as it may  deem  necessary  or  advisable.
Decisions  of the Plan  Administrator  shall be final and binding on all parties
with an interest in the Plan.

         (c)  Service  on the  Committee  shall  constitute  service  as a Board
member,  and  members of the  Committee  shall  accordingly  be entitled to full
indemnification  and  reimbursement  as Board  members for their  service on the
Committee.  No member of the  Committee  shall be liable for any act or omission
made in good faith with  respect  to the Plan or any  option  granted  under the
Plan.

     4.  OPTION GRANTS AND SHARE ISSUANCES

         (a) The persons  eligible to receive  share  issuances  under the Stock
Issuance  Program  ("Participant")  and/or option grants  pursuant to the Option
Grant Program ("Optionee") are as follows:

                                       2.

<PAGE>



               (i) key employees (including officers) of the Corporation (or its
     parent or subsidiary  corporations) who render services which contribute to
     the  success  and growth of the  Corporation  (or its parent or  subsidiary
     corporations)  or which may  reasonably be anticipated to contribute to the
     future success and growth of the  Corporation  (or its parent or subsidiary
     corporations);

               (ii) non-employee  members of the Board or the board of directors
     of any parent or subsidiary corporation); and

               (iii) those  consultants or independent  contractors  who provide
     valuable   services  to  the  Corporation  (or  its  parent  or  subsidiary
     corporations).

         (b) Non-employee members of the Board shall also be eligible to receive
automatic  option grants  pursuant to the provisions of the  Corporation's  1991
Director Stock Option Plan.

         (c) The Plan Administrator shall have full authority to determine,  (I)
with respect to the option  grants made under the Plan,  the number of shares to
be covered by each grant,  the time or times at which each granted  option is to
become exercisable,  the option price, and the maximum term for which the option
may remain  outstanding and (II) with respect to share issuances under the Stock
Issuance  Program,  the number of shares to be issued to each  Participant,  the
vesting  schedule  (if  any) to be  applicable  to the  issued  shares,  and the
purchase price to be paid by the individual for such shares.

         (d) The Plan Administrator  shall have the absolute discretion to grant
options  in  accordance  with  Article  II of the Plan  and/or to  effect  share
issuances in accordance with Article III of the Plan.

     5.  STOCK SUBJECT TO THE PLAN

         (a)  The  stock  issuable  under  the  Plan  shall  be  shares  of  the
Corporation's  authorized  but  unissued or  reacquired  common  stock  ("Common
Stock").  The maximum number of shares  issuable over the term of the Plan shall
not exceed 4,869,048 shares*,

- ----------------
*Adjusted to reflect (i) the 2.1-for-1  reverse  stock split of the  outstanding
 Common  Stock  effected  in  January  1992,  (ii)  the  850,000-share  increase
 authorized  for issuance  under the Plan  approved by the Board on December 14,
 1995 and approved by the  stockholders  at the 1996 Annual Meeting and (iii) an
 additional share increase of 2,000,000 shares  authorized by the Board on March
 19, 1997, subject to stockholder approval at the 1997 Annual Meeting.  From and
 after March 31, 1997,  not more than  4,119,840  shares may be issued under the
 Plan.

                                       3.

<PAGE>


subject to adjustment as provided in Section 5(c). Should an outstanding  option
under the Plan expire or terminate for any reason prior to exercise in full, the
shares  subject to the portion of the option not so exercised  will be available
for subsequent  option grants and share  issuances  under the Plan. Any unvested
shares issued under the Plan and subsequently repurchased by the Corporation, at
the option  exercise  or direct  issue  price paid per  share,  pursuant  to the
Corporation's repurchase rights under the Plan shall be added back to the number
of  shares  of  Common  Stock  reserved  for  issuance  under the Plan and shall
accordingly be available for reissuance  through one or more  subsequent  option
grants or direct stock issuances under the Plan. However,  the shares subject to
any option (or portion of an option) surrendered or cancelled in accordance with
Section 3 of Article II of the Plan shall not be available for subsequent option
grants or share issuances under the Plan.

         (b) In no event  may any one  individual  participating  in the Plan be
granted stock options,  separately  exercisable  stock  appreciation  rights and
direct  stock  issuances  for more than  750,000  shares of Common  Stock in the
aggregate over the remaining term of the Plan,  subject to adjustment  from time
to time in  accordance  with  paragraph  5(c) of this Article I. For purposes of
such limitation,  no stock options,  stock  appreciation  rights or direct stock
issuances granted prior to January 1, 1994 shall be taken into account.

         (c) If any change is made to the Common Stock  issuable  under the Plan
by  reason  of  any  stock  dividend,   stock  split,   combination  of  shares,
recapitalization,  or other change  affecting the outstanding  Common Stock as a
class  without the  Corporation's  receipt of  consideration,  then  appropriate
adjustments will be made to (i) the number and/or class of shares issuable under
the  Plan,  (ii) the  maximum  number  and/or  class of shares  for which  stock
options,  separately  exercisable  stock  appreciation  rights and direct  stock
issuances may be granted to any one  participant in the aggregate after December
31, 1993,  and (iii) the number  and/or class of shares and the option price per
share in effect under each  outstanding  option in order to prevent the dilution
or  enlargement  of rights and  benefits  under such  options.  The  adjustments
determined by the Plan Administrator will be final, binding and conclusive.

         (d) Common  Stock  issuable  under the Plan,  whether  under the Option
Grant Program or the Stock Issuance Program, may be subject to such restrictions
on transfer,  repurchase  rights or other  restrictions as are determined by the
Plan Administrator.

                                       4.

<PAGE>


                                   ARTICLE II

                              OPTION GRANT PROGRAM

     1.  TERMS AND CONDITIONS OF OPTIONS

         Options  granted  pursuant to the Plan shall be authorized by action of
the Plan  Administrator  and may,  at the Plan  Administrator's  discretion,  be
either incentive stock options qualified under Internal Revenue Code Section 422
("Incentive Options") or non-statutory options  ("Non-Statutory  Options") which
do not so qualify.  Individuals  who are not employees of the Corporation or its
parent or subsidiary  corporations  may only be granted  non-statutory  options.
Each granted  option shall be evidenced by one or more  instruments  in the form
approved by the Plan Administrator; provided, however, that each such instrument
shall comply with the terms and  conditions  specified  below.  Each  instrument
evidencing an Incentive Option shall, in addition,  be subject to the applicable
provisions of Section 2 of this Article II.

         (a) Option Price.

               (1) The  option  price  per  share  shall  be  fixed  by the Plan
Administrator,  but in no event  shall the  option  price per share be less than
eighty-five percent (85%) of the fair market value of a share of Common Stock on
the date of the option grant.

               (2) The option price will become immediately due upon exercise of
the option  and,  subject to the  provisions  of Article  IV,  Section 1 and the
instrument  evidencing  the  grant,  will  be  payable  in one of the  following
alternative forms:

                     (A)  full   payment  in  cash  or  check   payable  to  the
               Corporation;

               or

                     (B) full  payment  in shares of  Common  Stock  held by the
               Optionee for the requisite  period necessary to avoid a charge to
               the Corporation's  earnings for financial  reporting purposes and
               valued at fair market value on the Exercise Date (as such term is
               defined below); or

                     (C) full payment in a combination of shares of Common Stock
               held by the Optionee for the requisite  period necessary to avoid
               a charge to the  Corporation's  earnings for financial  reporting
               purposes and valued at fair market value on the Exercise Date and
               cash or check payable to the Corporation; or

                                       5.

<PAGE>


                     (D)  full  payment   through  a   broker-dealer   sale  and
               remittance  procedure  pursuant to which the  Optionee  (I) shall
               provide irrevocable  instructions to a designated  brokerage firm
               to effect the immediate sale of the purchased shares and remit to
               the  Corporation,  out  of the  sale  proceeds  available  on the
               settlement  date,  sufficient funds to cover the aggregate option
               price  payable  for the  purchased  shares  plus  all  applicable
               Federal  and State  income and  employment  taxes  required to be
               withheld by the  Corporation in connection with such purchase and
               (II) shall provide  directives to the  Corporation to deliver the
               certificates  for the purchased shares directly to such brokerage
               firm in order to complete the sale transaction.

         For purposes of this subsection  (a)(2), the Exercise Date shall be the
date on  which  written  notice  of the  option  exercise  is  delivered  to the
Corporation.  Except to the extent the sale and remittance procedure is utilized
in connection  with the exercise of the option,  payment of the option price for
the purchased shares must accompany such notice.

               (3) For  purposes  of  subsection  (1)  above  (and for all other
valuation  purposes under the Plan),  the fair market value of a share of Common
Stock on any relevant date under the Plan will be determined in accordance  with
the following provisions:

                     (A) If the  Common  Stock  is not  at the  time  listed  or
               admitted  to trading on any stock  exchange  but is traded on the
               Nasdaq National Market System,  the fair market value will be the
               closing selling price of one share of Common Stock on the date in
               question,  as such price is reported by the National  Association
               of Securities  Dealers  through the Nasdaq National Market System
               or any successor  system. If there is no reported closing selling
               price  for the  Common  Stock on the date in  question,  then the
               closing  selling price on the last  preceding date for which such
               quotation exists shall be determinative of fair market value.

                     (B) If the Common  Stock is at the time  listed or admitted
               to trading on any stock exchange, then the fair market value will
               be the closing  selling price of one share of Common Stock on the
               date in question  on the stock  exchange  determined  by the Plan
               Administrator  to be the primary market for the Common Stock,  as
               such price is officially quoted on such exchange.  If there is no
               reported  sale of Common  Stock on such  exchange  on the date in
               question,  then the fair market value will be the closing selling
               price on the exchange on the last  preceding  date for which such
               quotation exists.

                                       6.

<PAGE>


         (b) Term and Exercise of Options.  Each option  granted  under the Plan
will be  exercisable  at  such  time or  times  and  during  such  period  as is
determined by the Plan Administrator and set forth in the stock option agreement
evidencing  such grant.  However,  no option granted under this Plan will have a
term in excess of ten (10) years measured from the grant date.

         (c)  Limited  Transferability  of Options.  During the  lifetime of the
Optionee,  Incentive Options shall be exercisable only by the Optionee and shall
not be assignable or  transferable  other than by will or by the laws of descent
and distribution following the Optionee's death. However,  Non-Statutory Options
may, in connection  with the Optionee's  estate plan, be assigned in whole or in
part during the  Optionee's  lifetime to one or more  members of the  Optionee's
immediate  family  or to a trust  established  exclusively  for one or more such
family  members.  The  assigned  portion may only be  exercised by the person or
persons  who  acquire a  proprietary  interest  in the  option  pursuant  to the
assignment.  The terms  applicable to the assigned  portion shall be the same as
those in effect for the option immediately prior to such assignment and shall be
set forth in such documents issued to the assignee as the Plan Administrator may
deem appropriate.

         (d) Effect of Termination of Service.

               (1) Should an Optionee  cease to remain in Service for any reason
         (including death or permanent disability as defined in Section 22(e)(3)
         of the  Internal  Revenue  Code)  while  the  holder  of  one  or  more
         outstanding  options under the Plan,  then such option or options shall
         in no event remain exercisable for more than a twelve (12) month period
         (or such shorter period as is determined by the Plan  Administrator and
         set forth in the option agreement) following the date of such cessation
         of  Service  (and  under no  circumstances  shall  any such  option  be
         exercisable  after the specified  expiration  date of the option term).
         Each such  option  shall,  during  such  twelve  (12)  month or shorter
         period,  be exercisable  only to the extent of the number of shares (if
         any) for which the option is  exercisable on the date of such cessation
         of Service.  Upon the  expiration  of such twelve (12) month or shorter
         period or (if earlier)  upon the  expiration  of the option  term,  the
         option shall terminate and cease to be exercisable.

               (2)  Any  option  granted  to an  Optionee  under  the  Plan  and
         exercisable in whole or in part on the date of the Optionee's death may
         be  subsequently  exercised,  but only to the  extent of the  number of
         shares (if any) for which the option is  exercisable on the date of the
         Optionee's cessation of Service (less any shares subsequently purchased
         by  the  Optionee   thereunder   prior  to  death),   by  the  personal
         representative  of the Optionee's estate or by the person or persons to
         whom the option is transferred  pursuant to the  Optionee's  will or in
         accordance with the laws of descent and distribution, provided and only
         if such exercise occurs prior to the earlier of

                                       7.

<PAGE>


         (i) the first  anniversary of the date of the Optionee's  death or (ii)
         the specified  expiration  date of the option term. Upon the occurrence
         of the  earlier  event,  the  option  shall  terminate  and cease to be
         exercisable.

               (3)  The  Plan  Administrator  shall  have  complete  discretion,
         exercisable either at the time the option is granted or at any time the
         option remains outstanding, to permit one or more options granted under
         this Article II to be exercised,  during the applicable exercise period
         under  subparagraph (1) or (2) above, not only for the number of shares
         for which each such option is exercisable at the time of the optionee's
         cessation of Service but also for one or more  subsequent  installments
         of purchasable  shares for which the option would otherwise have become
         exercisable had such cessation of Service not occurred.

               (4) For  purposes of the  foregoing  provisions  of this  Section
         1(c),  an Optionee  shall be deemed to remain in Service for so long as
         such  individual  renders  services to the Corporation or any parent or
         subsidiary  corporation  on a  periodic  basis  in the  capacity  of an
         Employee,  a non-employee Board member or an independent  consultant or
         advisor.  The  Optionee  shall  be  deemed  to be an  Employee  of  the
         Corporation  for so long as the  Optionee  remains in the employ of the
         Corporation  or one or more of its parent or  subsidiary  corporations,
         subject to the control and direction of the employer entity not only as
         to the work to be  performed  but also as to the  manner  and method of
         performance.

         (e) Stockholder  Rights. An Optionee shall have none of the rights of a
stockholder with respect to any shares covered by the option until such Optionee
has  exercised the option,  paid the option price for the  purchased  shares and
been issued a stock certificate for the purchased shares.

         (f)  Repurchase  Rights.  The shares of Common Stock  acquired upon the
exercise  of  options  granted  under  the  Plan may be  subject  to one or more
repurchase   rights  of  the   Corporation  in  accordance  with  the  following
provisions:

               (1) The Plan  Administrator may in its discretion  subject one or
         more shares of Common Stock issued under this Article II to  repurchase
         by the  Corporation.  Any such repurchase right shall be exercisable by
         the  Corporation,  at the option  price paid per share,  for any or all
         unvested shares of Common Stock held by the Optionee under this Article
         II at the time of his or her cessation of Service.  The specific  terms
         and conditions upon which such repurchase right shall be so exercisable
         by the  Corporation,  including the  establishment  of the  appropriate
         vesting  schedule and other  provision for the expiration of such right
         in one or more

                                       8.

<PAGE>



         installments over the optionee's period of Service, shall be determined
         by the Plan  Administrator  and set forth in the instrument  evidencing
         such right.

               (2) All of the Corporation's  outstanding repurchase rights shall
         automatically  terminate,  and all shares  subject  to such  terminated
         rights  shall  immediately  vest in full,  upon the  occurrence  of any
         Corporate Transaction under Section 4 of this Article II, except to the
         extent:  (i) any such  repurchase  right  is, in  connection  with such
         Corporate Transaction,  to be assigned to the successor corporation (or
         parent  thereof)  or  (ii)  such  termination  is  precluded  by  other
         limitations   imposed  by  the  Plan  Administrator  at  the  time  the
         repurchase right is granted.

               (3)  The  Plan   Administrator   shall  have  the   discretionary
         authority,  exercisable either before or after the optionee's cessation
         of Service, to cancel the Company's outstanding  repurchase rights with
         respect to one or more shares  purchased or purchasable by the optionee
         under this Article II and thereby accelerate the vesting of such shares
         in connection with the optionee's cessation of Service.

     2.  INCENTIVE OPTIONS

         The terms and  conditions  specified  below shall be  applicable to all
Incentive Options granted under the Plan.  Incentive Options may only be granted
to  individuals  who  are  Employees  of  the  Corporation.  Options  which  are
specifically  designated  as  Non-Statutory  Options  when issued under the Plan
shall not be subject to such terms and conditions.

         (a)  Option  Price.  The  option  price per share of the  Common  Stock
subject  to an  Incentive  Option  shall in no event  be less  than one  hundred
percent  (100%) of the fair market  value of a share of Common Stock on the date
of grant.

         (b) Dollar  Limitation.  The aggregate fair market value (determined as
of the  respective  date or dates of grant) of the Common Stock for which one or
more options  granted to any Employee  under this Plan (or any other option plan
of the Corporation or its parent or subsidiary  corporations)  may for the first
time become  exercisable as Incentive Options during any one calendar year shall
not exceed the sum of One Hundred Thousand Dollars ($100,000). To the extent the
Employee holds two or more such options which become  exercisable  for the first
time in the same calendar year, the foregoing  limitation on the  exercisability
of such options as incentive  stock  options under the Federal tax laws shall be
applied on the basis of the order in which such options were granted.

                                       9.

<PAGE>


         (c) 10%  Stockholder.  If any individual to whom an Incentive Option is
granted  is at the time of such  grant the owner of stock (as  determined  under
Section 424(d) of the Internal Revenue Code) possessing 10% or more of the total
combined voting power of all outstanding  classes of stock of the Corporation or
any parent or subsidiary corporation,  then the option price per share shall not
be less than one  hundred and ten  percent  (110%) of the fair market  value per
share of the  Common  Stock on the grant  date,  and the  option  term shall not
exceed five (5) years, measured from the grant date.

         Except as modified by the  preceding  provisions of this Section 2, all
the provisions of the Plan shall be applicable to the Incentive  Options granted
hereunder.

     3.  STOCK APPRECIATION RIGHTS

         (a) One or more  Optionee  may,  upon such terms and  conditions as the
Plan  Administrator may establish at the time of the option grant or at any time
thereafter,  be granted  the right to  surrender  all or part of an  unexercised
option in exchange for a  distribution  equal in amount to the excess of (i) the
fair market value (on the  surrender  date) of the number of shares in which the
Optionee is at the time vested under the  surrendered  option or portion thereof
over  (ii) the  aggregate  option  price  payable  for such  vested  shares.  No
surrender of an option, however, shall be effective unless it is approved by the
Plan  Administrator.  If the surrender is so approved,  then the distribution to
which the option holder shall accordingly  become entitled under this subsection
3(a) may be made in shares of Common  Stock  valued at fair market value at date
of  surrender,  in cash,  or partly in shares  and  partly in cash,  as the Plan
Administrator shall in its sole discretion deem appropriate.

         (b)  If  the   surrender   of  an  option  is   rejected  by  the  Plan
Administrator,  then the option holder shall retain  whatever  rights the option
holder had under the surrendered option (or surrendered  portion thereof) on the
surrender  date and may  exercise  such rights at any time prior to the later of
(i) the expiration of the 5 business-day  period following receipt by the option
holder  of the  rejection  notice  or (ii) the last day on which  the  option is
otherwise  exercisable in accordance with the terms of the instrument evidencing
such option,  but in no event may such rights be exercised at any time after ten
(10) years following the date of the option grant.

         (c) Notwithstanding the foregoing  provisions of this Section 3, one or
more officers of the Corporation  subject to the short-swing profit restrictions
of the Federal securities laws may, in the Plan Administrator's sole discretion,
be granted limited stock  appreciation  rights in tandem with their  outstanding
options under this Article II. Each outstanding option with such a limited stock
appreciation right shall  automatically be cancelled,  to the extent exercisable
for vested shares of Common Stock,  upon the occurrence of a Hostile  Take-Over,
and the  Optionee  shall in return be entitled to a cash  distribution  from the
Corporation  in an amount  equal to the excess of (i) the fair market  value (on
the  cancellation  date) of the number of shares in which the Optionee is at the
time vested under

                                       10.

<PAGE>


the cancelled  option or cancelled  portion over (ii) the aggregate option price
payable for such vested shares. Such cash distribution shall be made within five
(5)  days  following  the  consummation  of  the  Hostile  Take-Over.  The  Plan
Administrator  shall  pre-approve,  at the time the limited  stock  appreciation
right is granted,  the subsequent  exercise of that right in accordance with the
terms of the grant and the  provisions  of this  subsection  3(c). No additional
approval of the Plan Administrator or the Board shall be required at the time of
the actual option surrender and cash distribution.  The balance (if any) of each
such option shall continue in full force and effect in accordance with the terms
and conditions of the instrument evidencing such grant.

         (d) For purposes of Section 3(c) above,  a Hostile  Take-Over  shall be
deemed to occur in the event any person or related group of persons  (other than
the Corporation or a person that directly or indirectly controls,  is controlled
by, or is under common  control with,  the  Corporation)  acquires  ownership of
securities possessing more than fifty percent (50%) of the total combined voting
power of the  Corporation's  outstanding  securities  pursuant  to a  tender  or
exchange offer made directly to the Corporation's  stockholders  which the Board
does not recommend such stockholders to accept.

         (e) The shares of Common  Stock  subject to any option  surrendered  or
cancelled for an appreciation  distribution pursuant to this Section V shall not
be available for subsequent option grants or share issuances under the Plan.

     4.  CORPORATE TRANSACTION

         (a) In the event of one or more of the  following  stockholder-approved
transactions ("Corporate Transaction"):

                 (i) a merger or acquisition in which the Corporation is not the
       surviving entity, except for a transaction the principal purpose of which
       is to change the State of incorporation;

                 (ii)  the  sale,  transfer  or  other  disposition  of  all  or
       substantially  all of the assets of the  Corporation  in  liquidation  or
       dissolution of the Corporation; or

                 (iii) any reverse  merger in which the  Corporation is acquired
       but continues in existence as a separate entity,

                 each  outstanding  option  under the Plan  shall  automatically
accelerate  so that each such option shall,  immediately  prior to the specified
effective date for such Corporate  Transaction,  become fully  exercisable  with
respect  to the total  number of shares of Common  Stock at the time  subject to
such option and may be exercised for all or any portion of such shares. However,
an outstanding option shall not so accelerate if and to the

                                       11.

<PAGE>


extent: (i) such option is, in connection with the Corporate Transaction, either
to be assumed by the successor  corporation  or parent thereof or to be replaced
with a  comparable  option  to  purchase  shares  of the  capital  stock  of the
successor  corporation or parent thereof or (ii) the acceleration of such option
is subject to other applicable  limitations imposed by the Plan Administrator in
the relevant option agreement.  The determination of comparability  under clause
(i) or  clause  (ii)  above  shall  be made by the Plan  Administrator,  and its
determination shall be final and conclusive.

         (b) Upon the consummation of the Corporate Transaction, all outstanding
options under the Plan shall immediately  terminate and cease to be exercisable,
except to the extent assumed by the successor corporation or parent thereof.

         (c) The exercisability as incentive stock options under the Federal tax
laws of any options  accelerated  in connection  with the Corporate  Transaction
shall remain subject to the applicable dollar limitation of Section 2(b).

         (d) If the  outstanding  options  under  the  Plan are  assumed  by the
successor  corporation (or parent  thereof) in the Corporate  Transaction or are
otherwise to continue in effect following such Corporate Transaction,  then each
such  assumed or  continuing  option  shall,  immediately  after such  Corporate
Transaction,  be  appropriately  adjusted to apply and pertain to the number and
class of securities or other property which would have been issued to the option
holder,  in  consummation  of the  Corporate  Transaction,  had the option  been
exercised   immediately  prior  to  such  Corporate   Transaction.   Appropriate
adjustments  shall also be made to the option price payable per share,  provided
the aggregate  option price payable for such  securities or other property shall
remain  the same.  In  addition,  the number  and class of  securities  or other
property  available for issuance  under the Plan following the  consummation  of
such Corporate Transaction shall be appropriately adjusted.

         (e) The grant of  options  under  this Plan  shall in no way affect the
right of the Corporation to adjust,  reclassify,  reorganize or otherwise change
its capital or business structure or to merge, consolidate,  dissolve, liquidate
or sell or transfer all or any part of its business or assets.

     5.  CANCELLATION AND NEW GRANT OF OPTIONS

         The Plan Administrator  shall have the authority to effect, at any time
and  from  time to  time,  with  the  consent  of the  affected  Optionees,  the
cancellation  of any or all  outstanding  options under the Plan and to grant in
substitution  therefor new options under the Plan covering the same or different
numbers of shares of Common  Stock but having an option price per share not less
than (i) eighty-five  percent (85%) of the fair market value of the Common Stock
on such grant date or (ii) one hundred  percent (100%) of such fair market value
in the case of an Incentive Option.

                                       12.

<PAGE>


     6.  EXTENSION OF EXERCISE PERIOD

         The Plan Administrator shall have full power and authority, exercisable
in its sole discretion,  to extend,  either at the time the option is granted or
at any time while the option remains  outstanding,  the period of time for which
the  option is to remain  exercisable  following  the  Optionee's  cessation  of
Service  from the twelve  (12)  month or shorter  period set forth in the option
agreement to such greater  period of time as the Plan  Administrator  shall deem
appropriate;   provided,  however,  that  in  no  event  shall  such  option  be
exercisable at any time after the specified expiration date of the option term.

                                       13.

<PAGE>


                                   ARTICLE III

                             STOCK ISSUANCE PROGRAM

     1.  TERMS AND CONDITIONS OF STOCK ISSUANCES

         Shares may be issued under the Stock  Issuance  Program  either through
direct and immediate  purchases  without any intervening  option grant under the
Option Grant  Program or upon the  subsequent  exercise of  outstanding  options
under the  Option  Grant  Program.  The issued  shares  will be  evidenced  by a
Restricted Stock Purchase  Agreement  ("Purchase  Agreement") that complies with
each of the terms and conditions of this Article III.

         (a) Share Price

               (1) The  purchase  price  per  share  will be  fixed  by the Plan
Administrator, but in no event will it be less than eighty-five percent (85%) of
the fair market  value of the shares at the time of  issuance.  Such fair market
value shall be determined in accordance with Article II, Section (1)(a)(3).

               (2)  Shares  shall be  issued  under  this  Article  III for such
consideration  as the Plan  Administrator  shall  from  time to time  determine,
provided that in no event shall shares be issued for consideration other than:

                     (A) cash or check payable to the Corporation; or

                     (B) promissory  note  payable to the  Corporation's  order,
                         which may be subject to cancellation by the Corporation
                         in whole or in part upon such terms and  conditions  as
                         the Plan Administrator shall specify.

         (b) Vesting Schedule

               (1) The interest of a  Participant  in the shares of Common Stock
issued to him or her under this Article III may, in the absolute  discretion  of
the Plan  Administrator,  be fully and  immediately  vested upon issuance or may
vest in one or more  installments in accordance  with the vesting  provisions of
subsection  (b)(4).  Except as  otherwise  provided in  subsection  (b)(2),  the
Participant may not transfer any of the Common Stock in which he or she does not
have  a  vested  interest;  accordingly,  all  unvested  shares  issued  to  the
Participant  under  this  Article  III Plan shall  bear the  restrictive  legend
specified in subsection (c)(1),  until such legend is removed in accordance with
subsection  (c)(2).  The  Participant,  however,  shall have all the rights of a
stockholder  with respect to the issued shares of Common  Stock,  whether or not
such shares are vested.  Accordingly,  the  Participant  shall have the right to
vote such shares and to receive any regular cash

                                       14.

<PAGE>


dividends or other  distributions  paid or made with respect to such shares. Any
new,  substituted or additional  securities or other property  (including  money
paid other than as a regular cash dividend)  which the holder of unvested Common
Stock may have the right to receive by reason of a stock dividend,  stock split,
stock  combination,   recapitalization  or  similar  transaction  affecting  the
Corporation's outstanding securities without receipt of consideration, or in the
event of the conversion of the Corporation's  outstanding Common Stock into cash
or other shares or securities of the  Corporation or any other  corporation as a
result of a merger, consolidation, liquidation or other reorganization involving
the Corporation shall be issued to such holder,  subject to (i) the same vesting
requirements  under subsection  (b)(4)  applicable to his or her unvested Common
Stock and (ii) such escrow  arrangements  as the Plan  Administrator  shall deem
appropriate.

               (2) As  used in this  Article  III,  the  term  "transfer"  shall
include  (without  limitation)  any  sale,  pledge,  encumbrance,  gift or other
disposition of any unvested  shares  acquired under the Stock Issuance  Program.
However,  the Participant  shall have the right to make a gift of one or more of
such  unvested  shares to his or her  spouse,  parents or children or to a trust
established  for such spouse,  parents or  children,  provided the donee of such
shares  delivers to the  Corporation a written  agreement to be bound by all the
provisions  of the Plan and other  instruments  executed by the  Participant  to
evidence  his or her  prior  acquisition  of  such  shares.  Any  gift  made  in
accordance with the foregoing  limitations shall not trigger the exercise of the
Corporation's repurchase rights under subsection (b)(3).

               (3) In the event a Participant should,  while his or her interest
in the acquired shares remains unvested,  (i) attempt to transfer (other than by
way of a permissible gift under subsection (b)(2)) any of the unvested shares or
any  interest  therein or (ii) cease to remain in Service (as defined in Section
1(c)(4) of Article II) for any reason  whatsoever,  then the  Corporation  shall
have the right to repurchase the unvested shares at the original  purchase price
paid by the  Participant and the  Participant  shall  thereafter have no further
stockholder rights with respect to the repurchased shares.

               (4) Any shares of Common Stock  issued  under the Stock  Issuance
Program which are not vested at the time of such  issuance  shall vest in one or
more installments thereafter.  The elements of the vesting schedule,  namely the
number  of  installments  in which  the  shares  are to vest,  the  interval  or
intervals (if any) which are to lapse between  installments and the effect which
death, disability or other event designated by the Plan Administrator is to have
upon the vesting  schedule,  shall be determined by the Plan  Administrator  and
shall be specified in the Purchase Agreement executed by the Corporation and the
Participant at the time of issuance of the unvested shares.

               (5) The Plan  Administrator  may in its  discretion  elect not to
exercise,  in  whole or in part,  its  repurchase  rights  with  respect  to any
unvested  Common  Stock or other  assets  which would  otherwise  at the time be
subject to repurchase  pursuant to the provisions of subsection (b)(3).  Such an
election may be made at any time the

                                       15.

<PAGE>


repurchase right is outstanding and shall result in the immediate vesting of the
Participant's  interest in the shares of Common  Stock as to which the  election
applies.

         (c) Stock Legends

               (1) Each certificate representing unvested shares of Common Stock
(or other  securities)  issued  under the Plan shall bear a  restrictive  legend
substantially as follows:

                  "The securities  represented by this  certificate are unvested
         and subject to repurchase by the Corporation pursuant to the provisions
         of the Restricted Stock Purchase  Agreement between the Corporation and
         the  registered  holder  of  the  securities  (or  his  predecessor  in
         interest).  Such  agreement  grants  certain  repurchase  rights to the
         Corporation in the event the registered  holder (or his  predecessor in
         interest)  terminates  his  employment or service with the  Corporation
         prior to vesting in the securities. A copy of such agreement is on file
         at the principal office of the Corporation."

               (2) As the interest of the Participant  vests with respect to any
stock certificate representing shares acquired under the Stock Issuance Program,
the  Corporation  shall,  upon the  Participant's  delivery of such  certificate
during  the period or periods  designated  each year by the Plan  Administrator,
issue a new certificate for the vested shares without the restrictive  legend of
subsection  (c)(1) and a second  certificate  for the balance of the shares with
such  legend.  If the  Participant's  shares  are held in  escrow at the time of
vesting,  then the stock  certificates  for the vested  shares shall be released
from escrow (without the restrictive  legend of subsection (c)(1)) and delivered
to the  Participant  during  the  period  or  periods  designated  by  the  Plan
Administrator  at  least  semi-annually  for  such  purpose  and  promptly  upon
Participant's  cessation of Service. If the Corporation repurchases any unvested
shares of the Participant  pursuant to the provisions of subsection  (b)(3), the
Corporation  shall  at  the  time  the  repurchase  is  effected  deliver  a new
certificate,  without the restrictive legend of subsection (c)(1),  representing
the number of shares (if any) in which the  Participant  is vested and which are
accordingly no longer subject to repurchase by the  Corporation  pursuant to the
provisions of subsection (b)(3).

     2.  CORPORATE TRANSACTION

         All of the  Corporation's  outstanding  repurchase  rights  under  this
Article  III shall  automatically  terminate,  and all  shares  of Common  Stock
subject to such  repurchase  rights  shall  immediately  vest in full,  upon the
occurrence  of  a  Corporate   Transaction,   except  to  the  extent:  (i)  the
Corporation's  outstanding repurchase rights are to be assigned to the successor
corporation (or parent thereof) in connection with the Corporate  Transaction or
(ii) the termination of such repurchase  rights and the  acceleration of vesting
are precluded by other limitations  imposed by the Plan Administrator  under the
terms of the applicable Purchase Agreements.

                                       16.

<PAGE>


                                   ARTICLE IV

                                  MISCELLANEOUS

     1.  LOANS OR INSTALLMENT PAYMENTS

         (a) The Plan Administrator may, in its discretion,  assist any Optionee
or Participant  (including an Optionee or  Participant  who is an officer of the
Corporation)  in the  exercise of one or more options  granted to such  Optionee
under the Article II Option Grant  Program or the purchase of one or more shares
issued to such  Participant  under the Article III Stock Issuance Program by (i)
authorizing  the  extension of a loan from the  Corporation  to such Optionee or
Participant  or (ii)  permitting  the Optionee or  Participant to pay the option
price or purchase price for the purchased  Common Stock in  installments  over a
period of years.  The terms of any such loan or  installment  method of  payment
(including the interest rate and terms of repayment) shall be upon such terms as
the Plan Administrator shall specify in the stock option agreement or restricted
stock purchase  agreement.  Such loans and  installment  payments may be made or
permitted with or without  security or collateral.  However,  the maximum credit
available  to the  Optionee  or  Participant  may not  exceed the sum of (i) the
aggregate  option price or purchase price payable for the purchased shares (less
the par  value)  plus (ii) any  federal  and state  income  and  employment  tax
liability  incurred  by the  Optionee or  Participant  in  connection  with such
exercise or purchase.

         (b) The Plan Administrator may, in its absolute  discretion,  determine
that one or more loans extended  under  subsection (a) above shall be subject to
forgiveness  by the  Corporation  in  whole  or in  part  upon  such  terms  and
conditions as the Plan Administrator in its discretion deems appropriate.

     2.  AMENDMENT OF THE PLAN AND AWARDS

         (a) The Board has the power and  authority  to amend or modify the Plan
in any or all respects whatsoever;  provided, however, that no such amendment or
modification  may  adversely  affect the rights  and  obligations  of the option
holders with respect to their outstanding  options under the Plan, nor adversely
affect the rights of any  Participant  with  respect to any  unvested  shares of
Common  Stock  issued  under the Plan  prior to such  Board  action,  unless the
Optionee  or  Participant  consents  to such  amendment.  In  addition,  certain
amendments  may require  stockholder  approval  pursuant to  applicable  laws or
regulations.

         (b) (i) Options to purchase shares of Common Stock may be granted under
the Option Grant Program and (ii) shares of Common Stock may be issued under the
Stock  Issuance  Program,  which  are in excess  of the  number  of shares  then
available for issuance under the Plan, provided (A) an amendment to increase the
maximum  number of shares  issuable under the Plan is adopted by the Board prior
to the initial grant of any such option

                                       17.

<PAGE>


or  the  issuance  of  any  such  shares  and  is  thereafter  submitted  to the
Corporation's  shareholders  for  approval  and (B) any excess  shares  actually
issued under the Option Grant Program or the Stock Issuance  Program are held in
escrow until such stockholder approval is obtained. If such stockholder approval
is not  obtained  within  twelve (12)  months  from the date the  share-increase
amendment is adopted by the Board,  then (i) any unexercised  options granted on
the basis of such increase shall  terminate and cease to be exercisable and (ii)
the  Corporation  shall promptly refund to the  Participants  the purchase price
paid for any excess  shares  issued under the Plan and held in escrow,  together
with  interest  (at the  interest  rate  necessary  to avoid the  imputation  of
interest  income under the Federal tax laws) for the period the shares were held
in escrow.

     3.  EFFECTIVE DATE AND TERM OF PLAN

         (a) The Plan was  initially  adopted by the Board on  September 2, 1988
and approved by the Corporation's  stockholders on February 28, 1989. On May 30,
1991, the Board approved a  523,809-share  increase** in the number of shares of
Common Stock  issuable under the Plan, and the Plan was restated in its entirety
on September 6, 1991.  Both the  523,809-share  increase and the September  1991
restatement  of the Plan were approved by the  stockholders  in January 1992. On
April 8, 1992,  the Board adopted a new  restatement  of the Plan to (i) conform
the Plan to the  requirements of Rule 16b-3 under the Federal  securities  laws,
(ii) revise the events in which an acceleration of options would occur and (iii)
provide that the  non-employee  members of the Board would no longer be eligible
to  participate  in the  Plan.  The  stockholders  approved  the  amendment  and
restatement  on May 11, 1993.  On March 15, 1994,  the Board amended the Plan to
(i) increase the number of shares issuable thereunder by 450,000 shares and (ii)
limit the number of shares of Common Stock for which any one  individual  may be
granted stock options,  stock appreciation  rights and direct stock issuances in
the aggregate under the Plan after December 31, 1993 to a maximum of twenty five
percent (25%) of the number of shares from time to time  authorized for issuance
under the Plan (the "25% Limit"). The stockholders approved the amendment on May
24,  1994.  The Board  amended the Plan on December 14, 1995 to (i) increase the
maximum  number of shares of Common Stock  issuable  thereunder by an additional
850,000  shares and (ii)  replace the 25% Limit on the maximum  number of shares
for which any one individual may be granted stock  options,  stock  appreciation
rights and direct stock  issuances in the aggregate after December 31, 1993 with
a specific limit of 750,000 shares. The 850,000-share  increase became effective
when adopted by the Board.  The new 750,000 share limit on the maximum number of
shares  for  which  any one  individual  may be  granted  stock  options,  stock
appreciation  rights and direct stock  issuances in the aggregate under the Plan
became   effective  when  adopted  by  the  Board  on  December  14,  1995.  The
stockholders approved the amendment on May 16, 1996.

- ------------
**Adjusted  to reflect the  2.1-for-1  reverse  stock  split to the  outstanding
  Common Stock effected in January 1992.

                                       18.

<PAGE>


         (b) The Plan was  amended  and  restated by the Board on March 19, 1997
(the "1997  Restatement")  to effect the  following  changes:  (i)  increase the
maximum  number of shares of Common Stock  authorized for issuance over the term
of the Plan from 2,869,048 shares to 4,869,048  shares,  (ii) extend the term of
the Plan  from  September  2,  1998 to  December  31,  2002,  (iii)  render  the
non-employee  Board members  eligible to receive  option grants and direct stock
issuances under the  Discretionary  Option Grant and Stock Issuance  Programs in
effect under the Plan,  (iii) allow  unvested  shares  issued under the Plan and
subsequently  repurchased  by the  Corporation  at the option  exercise price or
direct  issue  price paid per share to be reissued  under the Plan,  (iv) remove
certain  restrictions on the eligibility of non-employee  Board members to serve
as Plan  Administrator,  and (v)  effect a series of  additional  changes to the
provisions of the Plan  (including the  stockholder  approval  requirements)  in
order to take advantage of the recent amendments to Rule 16b-3 of the Securities
and Exchange Commission which exempts certain officer and director  transactions
under  the  Plan  from  the  short-swing  liability  provisions  of the  federal
securities laws. The 1997 Restatement is subject to stockholder  approval at the
1997  Annual   Meeting,   and  no  option  grants  made  on  the  basis  of  the
2,000,000-share increase shall become exercisable in whole or in part unless and
until  the  1997  Restatement  is  approved  by the  stockholders.  Should  such
stockholder  approval not be obtained,  then any options granted on the basis of
the 2,000,000-share  increase shall terminate without ever becoming  exercisable
for those shares,  and no further option grants or direct stock  issuances shall
be made on the basis of such share increase.  However,  option grants and direct
stock  issuances may continue to be made pursuant to the  provisions of the Plan
as in effect  immediately  prior to the 1997 Restatement  until the September 2,
1998 termination  date of the Plan.  Subject to the foregoing  limitations,  the
Plan  Administrator  may make option grants and direct stock issuances under the
Plan at any time before the date fixed herein for the termination of the Plan.

         (c) The provisions of each  restatement of the Plan shall apply only to
options  granted  under  the Plan  from and  after  the  effective  date of that
restatement. All options issued and outstanding under the Plan immediately prior
to each  such  restatement  shall  continue  to be  governed  by the  terms  and
conditions of the Plan (and the  instrument  evidencing  each such option) as in
effect on the date each such option was previously granted,  and nothing in that
restatement  shall be  deemed  to  affect  or  otherwise  modify  the  rights or
obligations  of the holders of such options with respect to the  acquisition  of
shares of Common Stock thereunder.

         (d) The sale and  remittance  procedure  authorized for the exercise of
outstanding  options under the Plan shall be available  for all options  granted
under the Plan on or after the effective date of the September 1991  restatement
and all non-statutory options outstanding under the Plan on such effective date.
The  Plan  Administrator  may  also  allow  such  procedure  to be  utilized  in
connection  with one or more  disqualifying  dispositions  of  Incentive  Option
shares effected after the effective date of the September 1991 restatement.

                                       19.

<PAGE>


         (e)  Unless  sooner   terminated   in   accordance   with  a  Corporate
Transaction,  the Plan shall  terminate  upon the  earlier of (i)  December  31,
2002*** or (ii) the date on which all shares  available  for issuance  under the
Plan shall have been issued or cancelled pursuant to the exercise,  surrender or
cash-out of the options  granted under the Option Grant Program and the issuance
or  repurchase  of  shares  under  the Stock  Issuance  Program.  If the date of
termination is determined under clause (i) above, then no options outstanding on
such date under Article II and no unvested shares issued and outstanding on such
date under  Article III shall be affected by the  termination  of the Plan,  and
each such  outstanding  option  and  unvested  share  issuance  will  thereafter
continue to have force and effect in accordance with the provisions of the stock
option  agreement  evidencing  each  such  Article  II option  and the  purchase
agreement evidencing each such unvested share issuance under Article III.

     4.  USE OF PROCEEDS

         Any cash  proceeds  received by the  Corporation  from the  issuance of
shares of Common Stock hereunder will be used for general corporate purposes.

     5.  WITHHOLDING

         The  Corporation's  obligation  to deliver  shares upon the exercise or
surrender of any options  granted  under  Article II or upon the purchase of any
shares  issued  under  Article III shall be subject to the  satisfaction  of all
applicable  federal,  state and local  income  and  employment  tax  withholding
requirements.

     6.  REGULATORY APPROVALS

         (a) The implementation of the Plan, the granting of any stock option or
stock  appreciation  right under the Option Grant  Program,  the issuance of any
shares under the Stock Issuance  Program,  and the issuance of Common Stock upon
the  exercise or  surrender of the stock  options or stock  appreciation  rights
granted  hereunder  shall be subject  to the  Corporation's  procurement  of all
approvals and permits  required by regulatory  authorities  having  jurisdiction
over the Plan, the options and stock  appreciation  rights granted under it, and
the Common Stock issued pursuant to it.

         (b) No  shares  of  Common  Stock or other  assets  shall be  issued or
delivered  under the Plan,  unless and until,  in the opinion of counsel for the
Corporation (or its successor in the event of any Corporate Transaction),  there
shall have been compliance  with all applicable  requirements of the Federal and
state securities exchange on which stock of

- ----------
***The extension of the term of the Plan from  September 2, 1998 to December 31,
   2002 is subject to stockholder approval at the 1997 Annual Meeting.

                                       20.

<PAGE>


the same  class is then  listed,  and all  other  requirements  of law or of any
regulatory bodies having jurisdiction over such issuance and delivery.

     7.  NO EMPLOYMENT/SERVICE RIGHTS

         Neither the action of the  Corporation in  establishing  this Plan, nor
any  action  taken by the  Board of the Plan  Administrator  hereunder,  nor any
provision  of this Plan shall be  construed  so as to grant any  individual  the
right to remain in the employ or service  of the  Corporation  (or any parent or
subsidiary corporation) for any period of specific duration, and the Corporation
(or  any  parent  or  subsidiary  corporation  retaining  the  services  of such
individual)  may terminate such  individual's  employment or service at any time
and for any reason, with or without cause.

                                       21.

<PAGE>


                                SPECIAL ADDENDUM

                            SHARED INVESTMENT PROGRAM


     1.  PURPOSE

         The Shared  Investment  Program (the  "Program") is hereby  implemented
under the 1988 Restated Stock Plan, effective March 19, 1997. The purpose of the
Program is to provide the  Corporation's  officers and other key employees  with
the opportunity to acquire shares of Common Stock as a long-term  investment and
thereby more closely align the interests of those  individuals with those of the
Corporation's stockholders. Specifically, the Program is intended to achieve the
following purposes:

         a.    more closely align the financial  rewards of  participants in the
               Program with the financial  rewards realized by all other holders
               of the Common Stock;

         b.    increase  the  motivation  of such  participants  to  manage  the
               Company as owners; and

         c.    increase  the  ownership  of Common  Stock among the officers and
               other key employees of the Company.

         All  capitalized  terms used in this  Special  Addendum  shall,  to the
extent not  specifically  defined  herein,  have the meanings  assigned to those
terms in the Plan.

     2.  PARTICIPATION

         The individuals eligible to participate in the Program shall be limited
to the officers and other key  employees of the  Corporation  listed in attached
Schedule  I. Each such  listed  individual  shall  become a  participant  in the
Program to the extent he or she  purchases  all or any  portion of the number of
shares of Common Stock allotted to such  individual in attached  Schedule I. Any
such purchase must be effected in  accordance  with the  provisions of Section 3
below.

     3.  PARTICIPATION

         To become an actual  participant  in the  Program  ("Participant"),  an
individual  listed in attached Schedule I must effect the purchase of all or any
portion of his or her Common Stock allotment under Schedule I as follows:


<PAGE>


         a.    submit a completed and executed Stock Purchase Agreement,  in the
               form approved by the Plan  Administrator,  which incorporates the
               provisions of the Program  applicable  to the  purchased  shares,
               including  (without  limitation) the gain/loss sharing provisions
               of Section 6;

         b.    execute  and  deliver  a   full-recourse   promissory   note,  in
               accordance with Section 4 below, in payment of the purchase price
               for the purchased shares;

         c.    execute and deliver a stock pledge agreement,  in accordance with
               Section 4 below, as collateral for the promissory note; and

         d.    satisfy all other  conditions of  participation  specified in the
               Plan.

         All such  agreements must be in such form and submitted at such time as
specified by the Plan Administrator.  No officer or other key employee listed in
attached  Schedule I is  required  to  purchase  any of his or her Common  Stock
allotment or otherwise to participate in the Program.

         The purchases  shall be effected in accordance  with the  provisions of
the Stock  Issuance  Program  under the Plan,  and the  purchased  shares  shall
reduce,  on a one-for-one  basis,  the number of shares of Common Stock reserved
for issuance under the Plan.  The purchased  shares shall be  fully-vested  upon
issuance and shall not be subject to the  Corporation's  repurchase rights under
Article III of the Plan.

     4.  PAYMENT OF PURCHASE PRICE

         The  purchase  price for all shares of Common  Stock  issued  under the
Program shall be equal to one hundred  percent (100%) of their Fair Market Value
at the  time  of  purchase.  The  purchase  price  shall  be  paid  through  the
Participant's delivery of a full-recourse  promissory note, substantially in the
form of attached Exhibit A (the "Promissory Note"),  payable to the order of the
Corporation.  The  Promissory  Note shall bear interest at the minimum per annum
rate, compounded semi-annually, required under the federal tax laws to avoid the
imputation of compensation income to the Participant.  The Promissory Note shall
have a maximum term of nine (9) years,  subject to  acceleration  in  accordance
with the provisions of this Program. The Promissory Note shall be secured by the
Participant's pledge of the purchased shares with the Corporation.  Accordingly,
the Participant shall, at the time of the purchase of those shares,  execute and
deliver to the  Corporation  a Stock  Pledge  Agreement  in the form of attached
Exhibit B, together with the certificate for the purchased shares accompanied by
a duly-executed assignment of stock powers.

                                      A-2.

<PAGE>


     5.  SALE OF PURCHASED SHARES

         Each  Participant  shall be permitted to sell all or any portion of the
shares of Common Stock he or she  purchases  under the Program  (the  "Purchased
Shares"), subject, however, to the following restrictions:

         a.    except  in  the  event  of  the  Participant's  death,  permanent
               disability (as defined in Internal Revenue Code Section 22(e)(3))
               or other  cessation of Service or the  occurrence  of a Change in
               Control  of the  Corporation,  the  Participant  may not sell any
               portion of the Purchased  Shares before the first  anniversary of
               the date on which he or she purchased those shares (the "Purchase
               Date");

         b.    the Participant may not sell any portion of the Purchased  Shares
               while there is any  outstanding  unpaid  balance  (principal  and
               accrued  interest) under his or her Promissory  Note,  unless the
               sale proceeds are simultaneously  applied first to the payment of
               the principal  portion of the  Promissory  Note  attributable  to
               those  shares  plus  the  accrued  and  unpaid  interest  on that
               principal portion; and

         c.    the Participant must notify the Finance  Department of his or her
               intention  to sell  the  Purchased  Shares  before  such  sale is
               effected.

         The Plan Administrator  shall have the right to impose  restrictions on
the timing,  amount and form of sale of the Purchased Shares with respect to any
Participant,   to  the  extent  the  Plan  Administrator  determines  that  such
restrictions are in the best interests of the Corporation.

     6.  SHARING OF GAIN OR LOSS

         If the  Participant  remains in Service until the first  anniversary of
the Purchase Date, then the Corporation  shall share the loss (if any) which the
Participant may incur upon the subsequent sale of the Purchased Shares. The loss
will be measured by the excess of (i) the purchase  price paid for the Purchased
Shares over (ii) the price at which those  shares are sold.  The risk of loss on
the Purchased Shares shall be allocated as follows:

         a.    to the extent any portion of the Purchased  Shares is sold before
               the third anniversary of the Purchase Date, the Participant shall
               be responsible for one hundred percent (100%) of the loss on that
               portion of the Purchased Shares; and

                                      A-3.

<PAGE>


         b.    to the extent any portion of the  Purchased  Shares is sold on or
               after the third anniversary of the Purchase Date, the Participant
               shall be responsible  for only fifty percent (50%) of the loss on
               that portion of the Purchased Shares.

         The Corporation  shall also be entitled under certain  circumstances to
share in the gain (if any) which the  Participant  may incur upon the subsequent
sale of the Purchased Shares. The gain will be measured by the excess of (i) the
price at which the Purchased  Shares are sold over (ii) the purchase  price paid
for those  shares.  The sharing of such gain on the  Purchased  Shares  shall be
allocated as follows:

         a.    to the extent any portion of the Purchased  Shares is sold before
               the second  anniversary  of the Purchase  Date,  the  Participant
               shall only be entitled to receive fifty percent (50%) of the gain
               on that portion of the Purchased Shares,  and the remaining fifty
               percent (50%) of the gain shall be paid over to the Corporation;

         b.    to the extent any portion of the  Purchased  Shares is sold on or
               after the second  anniversary of the Purchase Date but before the
               third  anniversary of such Purchase Date, the  Participant  shall
               only be entitled  to receive  seventy-five  percent  (75%) of the
               gain on that portion of the Purchased  Shares,  and the remaining
               twenty-five  percent  (25%) of the gain shall be paid over to the
               Corporation; and

         c.    to the extent any portion of the  Purchased  Shares is sold on or
               after the third anniversary of the Purchase Date, the Participant
               shall be entitled to receive  one hundred  percent  (100%) of the
               gain on that portion of the Purchased Shares.

         The gain/loss sharing  provisions of this Section 6 shall apply only to
the  extent  the  Purchased  Shares  are  sold by the  Participant  and the sale
proceeds are applied to payment of his or her Promissory Note in accordance with
subsection 5.b.

     7.  DEATH OR PERMANENT DISABILITY

         Should the  Participant  cease Service by reason of his or her death or
permanent  disability at any time while there is an  outstanding  unpaid balance
under his or her Promissory Note, then the Participant (or the representative of
his or her estate) may sell all or any portion of the Purchased Shares,  subject
only to the restrictions specified in subsections 5.b and 5.c. Upon the death of
a  Participant,  her or his  Promissory  Note shall become  immediately  due and
payable.

                                      A-4.

<PAGE>


         With respect to any Purchased Shares sold after the Participant's death
or permanent  disability and while there is an unpaid balance  outstanding under
his or her Promissory  Note, the  Participant  shall be not  responsible for any
loss  incurred  on the sale of those  Purchased  Shares and shall be entitled to
receive  one  hundred  percent  (100%) of any gain  realized  on the sale of the
Purchased Shares.

         This  Section 7 shall not be  applicable  to any sale of the  Purchased
Shares effected (i) before the  Participant's  death or permanent  disability or
(ii) after the payment of the entire  balance  owed under his or her  Promissory
Note.

     8.  OTHER CESSATION OF SERVICE

         Should the  Participant's  Service  terminate for any reason other than
death or permanent disability, then the following provisions shall apply:

         -     If  the   Participant's   Service   terminates  after  the  first
     anniversary  of the Purchase  Date,  then he or she shall remain subject to
     all of the terms and  conditions  of the Program,  as if his or her Service
     had not terminated,  including  specifically  the transfer  restrictions of
     subsections 5.b. and 5.c. and the gain/loss  sharing  provisions of Section
     6.

         -     If  the  Participant's   Service   terminates  before  the  first
     anniversary of the Purchase Date, then he or she shall be:

         a.    permitted  to  sell  the   Purchased   Shares,   subject  to  the
               restrictions specified in subsections 5.b. and 5.c.;

         b.    responsible for one hundred (100%) of the loss on the sale of the
               Purchased  Shares,  whether the sale is effected  before or after
               his or her Promissory Note is paid; and

         c.    entitled to receive only fifty  percent  (50%) of the gain on any
               sale of the Purchased  Shares,  and the  remaining  fifty percent
               (50%)   of  that   gain   shall   be  paid  to  the   Corporation
               simultaneously with the sale.

         -     If the Participant's  Service is involuntarily  terminated by the
     Corporation for any reason or if the Participant  voluntarily  resigns from
     Service,  then he or she will  have six (6)  months  to  repay  the  entire
     outstanding balance on his or her Promissory Note.

                                      A-5.

<PAGE>


     9.  CHANGE IN CONTROL

         Immediately  prior to the  consummation  of a Change  in  Control,  the
restrictions on the sale of the Purchased  Shares specified in Section 5.a shall
lapse. In addition, the following special provisions shall be in effect for each
Participant  who continues in Service  through the effective date of such Change
in Control:

         -     each  such  Participant  shall be  deemed  to have  continued  in
     Service until the first anniversary of the Purchase Date (should the Change
     in Control occur before the first anniversary of the Purchase Date), and

         -     each such Participant  shall be deemed to have sold the Purchased
     Shares after the third  anniversary  of the  Purchase  Date for purposes of
     Section 6 (should the sale of the  Purchased  Shares occur before the third
     anniversary of the Purchase Date).

         For  purposes of the  Program,  a Change in Control  shall be deemed to
occur upon a change in ownership or control of the Corporation  effected through
any of the following transactions:

               a. the  acquisition,  directly  or  indirectly,  by any person or
     related  group of persons  (other  than the  Corporation  or a person  that
     directly or  indirectly  controls,  is  controlled  by, or is under  common
     control with, the Corporation) of beneficial  ownership (within the meaning
     of Rule  13d-3 of the 1934 Act) of  securities  possessing  more than fifty
     percent  (50%) of the  total  combined  voting  power of the  Corporation's
     outstanding securities pursuant to a tender or exchange offer made directly
     to the Corporation's stockholders,

               b. a change  in the  composition  of the  Board  over a period of
     thirty-six  (36)  consecutive  months or less such that a  majority  of the
     Board  members  ceases,  by reason of one or more  contested  elections for
     Board  membership,  to be comprised of individuals who either (A) have been
     Board members  continuously  since the beginning of such period or (B) have
     been elected or nominated for election as Board members  during such period
     by at least a majority  of the Board  members  described  in clause (A) who
     were still in office at the time such election or  nomination  was approved
     by the Board, or

               c. the consummation of a Corporate Transaction.

                                      A-6.

<PAGE>


     10. LOSS SHARING IMPLEMENTATION

         Should the  Participant  sell any portion of the Purchased  Shares at a
loss (as  determined by the provisions of Section 6) while his or her Promissory
Note is outstanding,  then the Corporation  shall assume the portion (if any) of
that loss for which the  Participant  is not  responsible  pursuant  to the loss
sharing  provisions of Section 6. The Corporation  shall satisfy such obligation
by  delivering  a check  payable to the  Participant  in an amount equal to that
portion ("Risk Sharing Payment")  simultaneously with the Participant's  payment
of the outstanding unpaid balance of his or her Promissory Note.

         The  Corporation   anticipates  that  the  Risk  Sharing  Payment  will
constitute compensation income to the Participant,  subject to the Corporation's
collection  of all  applicable  income and  employment  withholding  taxes.  The
Corporation  also  anticipates  that the Risk Sharing Payment will be deductible
for federal  income tax  purposes as  compensation  in the taxable year in which
such payment is made. If the Corporation determines that it is not entitled to a
current  income  tax  deduction  for the Risk  Sharing  Payment by reason of the
limitations  imposed under Internal  Revenue Code Section 162(m) and the related
Treasury Regulations,  the Corporation will not make the Risk Sharing Payment to
the Participant in connection with the repayment of his or her Promissory  Note.
Instead the Participant shall be entitled to receive deferred compensation equal
to the  Risk  Sharing  Payment  at a time and in a form  which  will  allow  the
Corporation  to  obtain an  income  tax  deduction  for such  payment.  The Plan
Administrator   shall  have  the  sole   discretion   to  implement  a  deferred
compensation  arrangement  to the extent  necessary  or desirable to achieve the
intent of the preceding sentence.

     11. EFFECT OF PROGRAM

         The Program shall be governed by the provisions of the Plan,  except as
otherwise expressly stated in this Special Addendum.

     12. DISCRETIONARY AUTHORITY

         The Plan Administrator shall have the discretionary  authority to waive
any and all  transfer  restrictions,  Service  requirements  or  holding  period
requirements otherwise applicable to the Program under such circumstances as the
Plan Administrator may deem appropriate.

                                      A-7.






                                  Exhibit 99.6


<PAGE>

                           MATRIX PHARMACEUTICAL, INC.

                            STOCK ISSUANCE AGREEMENT


         AGREEMENT  made this  _____ day of June  1997,  by and  between  Matrix
Pharmaceutical,  Inc.,  a Delaware  corporation,  and  _____________________,  a
Participant in the Corporation's 1988 Restricted Stock Plan.

         All capitalized terms in this Agreement shall have the meaning assigned
to them in this Agreement or in the attached Appendix.


     A.  PURCHASE OF SHARES

         1. Purchase.  Participant hereby purchases  __________ shares of Common
Stock  (the  "Purchased  Shares")  pursuant  to the  provisions  of  the  Shared
Investment Program of the Plan at the purchase price of $_______________________
per share (the "Purchase Price").

         2.  Payment.  Concurrently  with the delivery of this  Agreement to the
Corporation,  Participant  shall pay the Purchase Price for the Purchased Shares
by delivering (i) a  full-recourse  Promissory  Note (the "Note") payable to the
Corporation  (in the form attached  hereto as Exhibit I) and (ii) a Stock Pledge
Agreement  (in the form  attached  hereto as Exhibit  II)  pursuant to which the
Purchased Shares shall serve as collateral for the payment of the Note.

         3.  Stockholder  Rights.  Participant  shall  have all the  rights of a
stockholder (including voting,  dividend and liquidation rights) with respect to
the Purchased Shares,  subject,  however,  to the transfer  restrictions of this
Agreement.  The  certificates  for the  Purchased  Shares  shall  be held by the
Corporation  under  the  Stock  Pledge  Agreement,  and  the  Participant  shall
accordingly deliver to the Corporation a duly-executed  Assignment Separate from
Certificate for each certificate  representing the Purchased Shares pledged with
the Corporation.

     B.  TRANSFER RESTRICTIONS

         1. Restrictions on Sale. The Participant shall be permitted to sell all
or any portion of Purchased Shares, subject to the following restrictions:

               a. The  Participant  may not sell any  portion  of the  Purchased
     Shares before the first  anniversary of Purchase Date,  except in the event
     of the  Participant's  death,  Permanent  Disability or other  cessation of
     Service or the occurrence of a Change in Control. Such restriction shall be
     applicable  whether  or not  there  is an  outstanding  balance  under  the
     Participant's Note.

               b. The  Participant  may not sell any  portion  of the  Purchased
     Shares while there is any outstanding unpaid balance (principal and accrued
     interest) under his or her Note, unless the proceeds realized from the sale
     of the Purchased Shares are simultaneously  applied first to the payment of
     the  principal  portion of the Note  attributable  to those shares plus the
     accrued and unpaid interest on that principal portion.



<PAGE>


               c.  The  Participant  shall  notify  the  Corporation's   Finance
     Department  prior to any sale of the  Purchased  Shares  while  there is an
     unpaid balance outstanding on his or her Note.

         2. Restrictive  Legend.  The stock certificate for the Purchased Shares
shall be endorsed with the following restrictive legend:

                           "The  shares  represented  by  this  certificate  are
     subject to certain transfer  restrictions  imposed pursuant to that certain
     Stock Issuance  Agreement between the Corporation and the registered holder
     of the shares (or the  predecessor  in interest to the shares) dated June ,
     1997 and may not be sold,  assigned,  transferred,  encumbered  or made the
     subject  of any  disposition  except in  conformity  with the terms of that
     Stock  Issuance  Agreement.  A copy of such  agreement is maintained at the
     Corporation's principal corporate offices."

     C.  SHARED INVESTMENT

     To the extent the Purchased Shares are sold by the Participant and the sale
proceeds  are to be applied to the  payment of his or her Note  pursuant  to the
requirements of Subsection B.1.b, the following provisions shall apply:

         1. Loss on Sale. If the Participant  remains in Service until the first
anniversary of the Purchase Date, then the Corporation  shall share the Loss (if
any) which the  Participant  may incur upon the subsequent sale of the Purchased
Shares.  The risk of the Loss on the  Purchased  Shares  shall be  allocated  as
follows:

               a. To the extent  any  portion  of the  Purchased  Shares is sold
     before the third anniversary of the Purchase Date, the Participant shall be
     responsible  for one hundred  percent  (100%) of the Loss  incurred on that
     portion of the Purchased Shares.

               b. To the extent any portion of the  Purchased  Shares is sold on
     or after the third  anniversary of the Purchase Date, the Participant shall
     be responsible  for only fifty percent (50%) of the Loss on that portion of
     the Purchased Shares.

         2.  Gain on Sale.  The  Corporation  shall be  entitled  under  certain
circumstances  to share in the Gain (if any) which the  Participant  may realize
upon the subsequent  sale of the Purchased  Shares.  The sharing of such Gain on
the Purchased Shares shall be allocated a follows:

               a. To the extent  any  portion  of the  Purchased  Shares is sold
     before the second  anniversary of the Purchase Date, the Participant  shall
     only be entitled to receive fifty percent (50%) of the Gain on that portion
     of the Purchased Shares,  and the remaining fifty percent (50%) of the Gain
     shall immediately be paid over to the Corporation.

               b. To the extent any portion of the  Purchased  Shares is sold on
     or after the second  anniversary  of the Purchase Date but before the third
     anniversary of such Purchase Date, the  Participant  shall only be entitled
     to receive  seventy-five  percent  (75%) of the Gain on that portion of the
     Purchased Shares, and the remaining  twenty-five  percent (25%) of the Gain
     shall immediately be paid over to the Corporation.

               c. To the extent any portion of the  Purchased  Shares is sold on
     or after the third  anniversary of the Purchase Date, the Participant shall
     be  entitled  to receive  one  hundred  percent  (100%) of the Gain on that
     portion of the Purchased Shares.

                                       2.

<PAGE>


         3. Death or Permanent Disability.  Should the Participant cease Service
by reason of his or her death or Permanent Disability at any time while there is
an outstanding  unpaid balance under his or her Note,  then the  Participant (or
the  representative  of his or her  estate)  may sell all or any  portion of the
Purchased  Shares,  subject only to the  restrictions  specified in  Subsections
B.1.b and B.1.c.  Upon the  Participant's  death,  her or his Note shall  become
immediately due and payable.

            With respect to any  Purchased  Shares sold after the  Participant's
death or Permanent Disability while there is an unpaid balance outstanding under
his or her Note, the Participant  shall be not responsible for any Loss incurred
on the sale of those  Purchased  Shares and shall be  entitled  to  receive  one
hundred percent (100%) of any Gain realized on the sale of the Purchased Shares.

            This Section 3 shall not be  applicable to any sale of the Purchased
Shares effected (i) before the  Participant's  death or Permanent  Disability or
(ii) after the payment of the entire balance owed under his or her Note.

         4. Other Cessation of Service. Should the Participant cease Service for
any  reason  other  than  death or  Permanent  Disability,  then  the  following
provisions shall apply:

               a.  Should  such  cessation  of  Service  occur  before the first
     anniversary  of the  Purchase  Date,  then (i) all  sales of the  Purchased
     Shares shall remain  subject to the  restrictions  specified in Subsections
     B.1.b.  and  B.1.c.  of this  Agreement,  (ii)  the  Participant  shall  be
     responsible for one hundred percent (100%) of any Loss incurred on the sale
     of the Purchased  Shares,  whether the sale is effected before or after his
     or her Note is paid, and (iii) the Participant shall be entitled to receive
     only fifty  percent (50%) of any Gain realized on any sale of the Purchased
     Shares, and the remaining fifty percent (50%) of that Gain shall be paid to
     the Corporation simultaneously with the sale.

               b. Should such  cessation of Service  occur on or after the first
     anniversary  of the  Purchase  Date,  all  terms  and  conditions  of  this
     Agreement  shall apply to the sale of the Purchased  Shares,  including the
     transfer  restrictions  of  Subsections  B.1.b and B.1.c and the  Gain/Loss
     sharing provisions of Subsections C.1. and C.2. of this Agreement.

         5. Change in Control

            Immediately  prior to the  consummation of a Change in Control,  the
restriction on the sale of the Purchased Shares  specified in Subsections  B.1.a
of this  Agreement  shall lapse.  In  addition,  if the  Participant  remains in
Service through the effective date of such Change in Control, then the following
special provisions shall be in effect:

               a. The  Participant  shall be deemed to have continued in Service
     until the first  anniversary  of the  Purchase  Date  (should the Change in
     Control occur before the first anniversary of the Purchase Date).

               b. The  Participant  shall be deemed  to have sold the  Purchased
     Shares after the third  anniversary  of the  Purchase  Date for purposes of
     Subsections  C.1.  and  C.2.  of this  Agreement  (should  the  sale of the
     Purchased Shares occur before the third anniversary of the Purchase Date).

         6. Risk Sharing Payment. Should the Participant sell any portion of the
Purchased Shares at a Loss while the balance of his or her Note  attributable to
those shares remains unpaid and

                                       3.

<PAGE>


outstanding, then the Corporation shall assume the portion (if any) of that Loss
for  which the  Participant  is not  responsible  pursuant  to the loss  sharing
provisions  of  Subsection  C.1. or C.3.  The  Corporation  shall  satisfy  such
obligation by delivering a check payable to the  Participant  in an amount equal
to that portion ("Risk Sharing Payment")  simultaneously  with the Participant's
payment of the portion of the unpaid balance of his or her Note  attributable to
the  Purchased  Shares  which are the  subject  of that  sale.  The  Corporation
anticipates that the Risk Sharing Payment will constitute compensation income to
the  Participant,  subject to the  Corporation's  collection  of all  applicable
income and employment  withholding  taxes. The Corporation also anticipates that
the Risk Sharing  Payment will be deductible  for federal income tax purposes as
compensation in the taxable year in which such payment is made. However,  should
the  Corporation  determine that it will be not entitled to a current income tax
deduction  for the Risk  Sharing  Payment by reason of the  limitations  imposed
under  Code  Section  162(m)  and the  related  Treasury  Regulations,  then the
Corporation  shall  not make the Risk  Sharing  Payment  to the  Participant  in
connection with the repayment of his or her Note.  Instead the Participant shall
be entitled to receive deferred  compensation  equal to the Risk Sharing Payment
at a time and in a form which will allow the Corporation to obtain an income tax
deduction  for  that  payment.  The  Plan  Administrator  shall  have  the  sole
discretion to set the terms and conditions on which such a deferred compensation
arrangement is to be implemented.

     D.  GENERAL PROVISIONS

         1. No Employment or Service  Contract.  Nothing in this Agreement or in
the Plan shall confer upon  Participant any right to continue in Service for any
period of specific  duration or interfere with or otherwise  restrict in any way
the  rights  of the  Corporation  (or any  Parent  or  Subsidiary  employing  or
retaining  Participant)  or of  Participant,  which rights are hereby  expressly
reserved by each, to terminate Participant's Service at any time for any reason,
with or without cause.

         2. Notices.  Any notice required to be given under this Agreement shall
be in writing  and shall be deemed  effective  upon  personal  delivery  or upon
deposit in the U.S. mail, registered or certified,  postage prepaid and properly
addressed to the party  entitled to such notice at the address  indicated  below
such party's  signature  line on this Agreement or at such other address as such
party may designate by ten (10) days advance written notice under this paragraph
to all other parties to this Agreement.

         3. No Waiver.  A waiver of any breach or  condition  of this  Agreement
shall  not be  deemed  to be a waiver  of any  other  or  subsequent  breach  or
condition, whether of like or different nature.

         4. Participant Undertaking.  Participant hereby agrees to take whatever
additional action and execute whatever additional  documents the Corporation may
deem  necessary  or advisable in order to carry out or effect one or more of the
obligations  or  restrictions  imposed on either  Participant  or the  Purchased
Shares pursuant to the provisions of this Agreement.

         5. Agreement is Entire Contract.  This Agreement constitutes the entire
contract  between the parties  hereto with regard to the subject  matter hereof.
This  Agreement is made pursuant to the  provisions of the Plan and shall in all
respects be construed in conformity  with the terms of the Plan.  This Agreement
may be  executed  in  counterparts,  each of  which  shall  be  deemed  to be an
original,  but  all  of  which  together  shall  constitute  one  and  the  same
instrument.

         6. Governing Law. This Agreement shall be governed by, and construed in
accordance  with,  the laws of the State of  California  without  resort to that
State's conflict-of-laws rules.

         7. Successors and Assigns. The provisions of this Agreement shall inure
to the benefit of, and be binding upon, the  Corporation  and its successors and
assigns   and   upon   Participant,   Participant's   assigns   and  the   legal
representatives, heirs and legatees of Participant's estate, whether or not

                                       4.

<PAGE>


any such person shall have become a party to this  Agreement  and have agreed in
writing to join herein and be bound by the terms hereof.

            IN WITNESS WHEREOF,  the parties have executed this Agreement on the
day and year first indicated above.

                                         MATRIX PHARMACEUTICAL, INC.

                                         By:____________________________________

                                         Title:_________________________________

                                         Address:_______________________________

                                         _______________________________________


                                         _______________________________________


                                         PARTICIPANT

                                         Address:_______________________________

                                         _______________________________________



                                       5.

<PAGE>



                                    APPENDIX

        The following definitions shall be in effect under the Agreement:


     A. Agreement shall mean this Stock Issuance Agreement.

     B. Board shall mean the Corporation's Board of Directors.

     C. Change in Control shall be deemed to occur upon a change in ownership or
control of the Corporation effected through any of the following transactions:

         (i) a merger or consolidation in which securities  possessing more than
     fifty percent (50%) of the total combined voting power of the Corporation's
     outstanding  securities are  transferred  to a person or persons  different
     from  the  persons  holding  those  securities  immediately  prior  to such
     transaction,

         (ii) the sale,  transfer or other  disposition of all or  substantially
     all of the Corporation's  assets in complete  liquidation or dissolution of
     the Corporation,

         (iii) the acquisition, directly or indirectly, by any person or related
     group of persons  (other than the  Corporation or a person that directly or
     indirectly controls, is controlled by, or is under common control with, the
     Corporation) of beneficial  ownership  (within the meaning of Rule 13d-3 of
     the 1934 Act) of securities possessing more than fifty percent (50%) of the
     total combined  voting power of the  Corporation's  outstanding  securities
     pursuant to a tender or exchange  offer made directly to the  Corporation's
     stockholders, or

         (iv) a  change  in  the  composition  of the  Board  over a  period  of
     thirty-six  (36)  consecutive  months or less such that a  majority  of the
     Board  members  ceases,  by reason of one or more  contested  elections for
     Board  membership,  to be comprised of individuals who either (A) have been
     Board members  continuously  since the beginning of such period or (B) have
     been elected or nominated for election as Board members  during such period
     by at least a majority  of the Board  members  described  in clause (A) who
     were still in office at the time such election or  nomination  was approved
     by the Board.

     D. Code shall mean the Internal Revenue Code of 1986, as amended.

     E. Common Stock shall mean the Corporation's common stock.

     F.  Corporation  shall  mean  Matrix   Pharmaceutical,   Inc.,  a  Delaware
corporation.

     G. Gain shall mean the excess of (i) the  aggregate  pre-tax sale  proceeds
realized upon the sale of one or more  Purchased  Shares over (ii) the aggregate
Purchase Price paid for those Purchased Shares.

     H. Loss shall mean the excess of (i) the aggregate  Purchase Price paid for
one or more Purchased Shares which are subsequently sold by the Participant over
(ii)  the  aggregate  pre-tax  sale  proceeds  realized  upon  the sale of those
Purchased Shares.



<PAGE>


     I. Note shall mean the  purchase-money  promissory  note of the Participant
payable to  Corporation  in  connection  with the  acquisition  of the Purchased
Shares.

     J. Parent shall mean any  corporation  (other than the  Corporation)  in an
unbroken  chain of  corporations  ending  with the  Corporation,  provided  each
corporation in the unbroken chain (other than the Corporation) owns, at the time
of the determination,  stock possessing fifty percent (50%) or more of the total
combined  voting power of all classes of stock in one of the other  corporations
in such chain.

     K.  Participant  shall  mean the  person to whom the  Purchased  Shares are
issued under the Shared Investment Program.

     L.  Permanent  Disability  shall mean the inability of the  Participant  to
engage  in  any  substantial   gainful  activity  by  reason  of  any  medically
determinable  physical  or mental  impairment  expected to result in death or to
have a continuous duration of twelve (12) consecutive months or more.

     M. Plan shall mean the Corporation's 1988 Restricted Stock Plan.

     N. Plan  Administrator  shall mean the Compensation  Committee of the Board
acting in its capacity as administrator of the Plan.

     O. Purchase Date shall mean the date on which the Participant purchases the
Purchased Shares.

     P. Purchase Price shall have the meaning assigned to such term in Paragraph
A.1.

     Q.  Purchased  Shares  shall  have the  meaning  assigned  to such  term in
Paragraph A.1.

     R. Service  shall mean the  Participant's  performance  of services for the
Corporation  (or any  Parent or  Subsidiary)  in the  capacity  of an  employee,
subject to the control and direction of the employer  entity as to both the work
to be performed and the manner and method of performance,  a non-employee member
of the board of directors or a consultant.

     S. Shared Investment  Program shall mean the Shared  Investment  Program in
effect under the Plan.

     T. Stock Pledge Agreement shall mean the agreement  between the Corporation
and the Participant  pursuant to which the Purchased Shares have been pledged as
security for the Note.

     U. Subsidiary shall mean any corporation (other than the Corporation) in an
unbroken chain of  corporations  beginning with the  Corporation,  provided each
corporation (other than the last corporation) in the unbroken chain owns, at the
time of the  determination,  stock possessing fifty percent (50%) or more of the
total  combined  voting  power  of all  classes  of  stock  in one of the  other
corporations in such chain.

                                       2.






                                  Exhibit 99.7


<PAGE>

                           MATRIX PHARMACEUTICAL, INC.
                        1991 DIRECTORS STOCK OPTION PLAN



                     AS AMENDED AND RESTATED MARCH 19, 1997


<PAGE>



                                    ARTICLE I

                               GENERAL PROVISIONS

PURPOSES OF THE PLAN

     This 1991  Directors  Stock Option Plan (the "Plan") is intended to promote
the  interests  of Matrix  Pharmaceutical,  Inc.,  a Delaware  corporation  (the
"Corporation"),  by offering  non-employee members of the Board of Directors the
opportunity to participate in a special stock option program designed to provide
them with significant incentives to remain in the service of the Corporation.

ELIGIBILITY

     A. Each non-employee  member of the  Corporation's  Board of Directors (the
"Board") shall be eligible to receive  automatic  option grants  pursuant to the
provisions of Article II below.

     B. In addition to the  automatic  option  grants to be made pursuant to the
provisions  of  Article  II below,  non-employee  Board  members  shall  also be
eligible to receive  option grants or stock  issuances  under the  Corporation's
1988  Restricted  Stock Plan or any other stock plan of the  Corporation  or its
Parent or Subsidiary corporations.

STOCK SUBJECT TO THE PLAN

     A. The stock issuable  under the Plan shall be shares of the  Corporation's
common stock ("Common Stock"). Such shares may be made available from authorized
but unissued shares of Common Stock or shares of Common Stock  reacquired by the
Corporation.  The aggregate  number of issuable shares of Common Stock shall not
exceed 592,858(1) shares,  subject to adjustment from time to time in accordance
with  subparagraph D below.  Such share reserve  reflects the 2.1-for-1  reverse
stock split of the outstanding Common Stock effected in January 1992.

     B. Should an option expire or terminate for any reason prior to exercise in
full, the shares subject to the portion of the option not so exercised  shall be
available for  subsequent  option grants under this Plan.  Shares subject to any
option cancelled in accordance with the automatic cancellation provisions of the
Plan shall not be available for reissuance under the Plan.

- -------------

(1) Includes (i) the 200,000-share  increase  authorized by the Board on May 24,
1994 and approved by the  stockholders  at the 1995 Annual  Meeting and (ii) the
250,000-share  increase  authorized  by the Board on March 19, 1997,  subject to
stockholder approval at the 1997 Annual Meeting.


<PAGE>


     C. Should the total number of shares at the time  available for grant under
the  Plan  not be  sufficient  for  the  automatic  grants  to be  made  at that
particular time to the  non-employee  Board members,  then the available  shares
shall be allocated  proportionately among all the automatic grants to be made at
that time.

     D. In the event any change is made to the Common Stock  issuable  under the
Plan by  reason of any stock  split,  stock  dividend,  combination  of  shares,
exchange of shares or other change  affecting the outstanding  Common Stock as a
class  without  the   Corporation's   receipt  of   consideration,   appropriate
adjustments  will be made to (i) the aggregate  number and/or class of shares of
securities  available for issuance under the Plan,  (ii) the number and/or class
of  securities  to be made the subject of each  subsequent  automatic  grant and
(iii) the number and/or class of securities  purchasable  under each outstanding
option and the exercise price payable per share in order to prevent the dilution
or enlargement of benefits thereunder.

VALUATION

     For purposes of  establishing  the option price and for all other valuation
purposes  under the Plan, the Fair Market Value per share of Common Stock on any
relevant date shall be determined in accordance with the following rules:

         (i) If the Common  Stock is not at the time  listed or admitted to
     trading on any stock  exchange  but is traded on the  Nasdaq  National
     Market,  then the Fair Market Value shall be the closing selling price
     per share of Common  Stock on the date in  question,  as such price is
     reported by the National  Association of Securities  Dealers,  Inc. on
     the Nasdaq  National  Market or any successor  system.  If there is no
     reported  closing  selling  price for the Common  Stock on the date in
     question,  then the closing  selling price on the last  preceding date
     for which such quotation  exists shall be determinative of Fair Market
     Value.

         (ii) If the  Common  Stock is at the time  listed or  admitted  to
     trading on any stock exchange, then the Fair Market Value shall be the
     closing  selling  price  per  share  of  Common  Stock  on the date in
     question on the stock  exchange  serving as the primary market for the
     Common Stock, as such price is officially quoted on such exchange.  If
     there is no reported sale of Common Stock on such exchange on the date
     in question,  then the Fair Market Value shall be the closing  selling
     price on the  exchange  on the last  preceding  date  for  which  such
     quotation exists.

                                       2.

<PAGE>


PARENT AND SUBSIDIARY CORPORATIONS

     A. A corporation shall be deemed to be a Parent of the Corporation if it is
one of the  corporations  (other than the  Corporation)  in an unbroken chain of
corporations ending with the Corporation,  provided each such corporation (other
than the Corporation) owns, at the time of determination, stock possessing fifty
percent (50%) or more of the total combined voting power of all classes of stock
in one of the other corporations in such chain.

     B. A corporation  shall be deemed to be a Subsidiary of the  Corporation if
it is one of the corporations  (other than the Corporation) in an unbroken chain
of corporations  beginning with the Corporation,  provided each such corporation
(other than the last  corporation  in the unbroken  chain) owns,  at the time of
determination,  stock  possessing  fifty  percent  (50%)  or more  of the  total
combined  voting power of all classes of stock in one of the other  corporations
in such chain. For purposes of the Corporate Transaction provisions of the Plan,
the term "Subsidiary" shall also include any partnership, joint venture or other
business entity of which the Corporation  owns,  directly or indirectly  through
another  subsidiary  corporation,  more than a fifty percent  (50%)  interest in
voting power, capital or profits.

                                       3.

<PAGE>


                                   ARTICLE II

                             AUTOMATIC GRANT PROGRAM

GRANT DATES

     A. Initial  Grant.  Each  individual  who initially  becomes a non-employee
Board  member at any time on or after the May 24,  1994  effective  date of this
plan restatement,  whether through election at an Annual Stockholders Meeting or
through appointment by the Board, shall automatically be granted, at the time of
such initial election or appointment,  a non-statutory  stock option to purchase
40,000 shares of Common Stock upon the terms and  conditions of this Article II,
provided  such  individual  has not  previously  served  as an  employee  of the
Corporation or any Parent or Subsidiary of the Corporation.

     B. Annual Grant. On the date of each Annual Stockholders  Meeting beginning
with the first Annual Stockholders Meeting held after the May 24, 1994 effective
date  of  this  plan  restatement,  each  individual  who  is  re-elected  as  a
non-employee member of the Board at such Annual Stockholders  Meeting (including
individuals who were initially  elected as  non-employee  Board members prior to
May 24, 1994) shall  receive an automatic  option grant under the Plan for 3,000
shares of Common Stock,  provided such individual has been a member of the Board
for at least six (6) months.

     C. Special Grants.  The following special option grants shall be made under
the Plan:

               1.  Each  individual  who was not  eligible  to  receive  an
     initial  option grant under the Plan for 23,810 shares of Common Stock
     when the Plan originally  became  effective on January 28, 1992 shall,
     in connection with the subsequent  cessation of his  affiliation  with
     the  venture  capital  fund or other  investment  entity or  corporate
     partner with which he was affiliated on such earlier  effective  date,
     receive a special stock option grant for 40,000 shares of Common Stock
     on the  later  of (i) the May 24,  1994  effective  date of this  plan
     restatement or (ii) the date upon which such affiliation  ceases. Such
     individual,  however, shall not be eligible to receive his or her next
     3,000- share annual  option grant until the first Annual  Stockholders
     Meeting  held  more than six (6)  months  after the date of his or her
     special 40,000-share grant hereunder.

               2. Each individual who receives his or her initial automatic
     option grant under  Paragraph A of this Grant Dates  section at a time
     when such individual is otherwise  contractually committed to transfer
     the economic  benefit of that grant and each  subsequent  grant to the
     venture capital fund or other investment  entity or corporate  partner
     with which he or she is  affiliated,  whether as  partner,  principal,
     stockholder or employee, and who subsequently

                                       4.

<PAGE>


     ceases  to be  affiliated  with  the  venture  capital  fund or  other
     investment  entity or corporate  partner shall,  immediately upon such
     cessation of  affiliated  status,  receive a second stock option grant
     for 40,000 shares of Common Stock. Such individual, however, shall not
     be eligible to receive his or her next 3,000-share annual option grant
     until the first  Annual  Stockholders  Meeting  held more than six (6)
     months  after  the  date  of  his or her  special  40,000-share  grant
     hereunder.

     All non-employee  Board members will be eligible for a special option grant
in accordance with the foregoing  criteria,  whether they first joined the Board
before or after the May 24, 1994 effective date of this plan restatement.

     D. The 40,000-share  limitation on the initial and special automatic option
grants and the 3,000-share  limitation on the automatic option grants to be made
annually  to each  non-employee  Board  member  shall  be  subject  to  periodic
adjustment pursuant to the applicable provisions of Article I.

TERMS AND CONDITIONS OF GRANT

     Each option granted in accordance  with the automatic  grant  provisions of
this Plan  shall be  evidenced  by an  instrument  in the form of the  prototype
non-statutory  stock  option  agreement  attached  to the  Plan  as  Exhibit  A.
Accordingly,  each such automatic  grant shall be subject to the following terms
and conditions:

1.       Option Price.

         The option price per share shall be one hundred  percent  (100%) of the
Fair Market Value per share of Common Stock on the automatic grant date.

2.       Term and Exercisability of Options.

         a. Initial  Grant.  Provided the optionee  continues as a Board Member,
each initial automatic option grant under Paragraph A of the Grant Dates section
shall  become  exercisable  for one or more of the  option  shares  in three (3)
successive annual installments as follows:

               (i) The first  installment  equal to  one-third of the total
     option shares shall become exercisable on the first anniversary of the
     grant date,  provided optionee attends all of the  regularly-scheduled
     Board meetings held during the one-year period measured from the grant
     date.  To the  extent  that  optionee  attends  less  than all of such
     meetings, the option shall lapse as to the number of shares determined
     by multiplying one-third of the total option shares by a fraction, the
     numerator of which is the number of such  meetings  which the optionee
     did not attend during such one-year period and

                                       5.

<PAGE>


     the  denominator  of which is the total number of such  meetings  held
     during that period.  Any option  shares as to which the option  lapses
     shall no longer be subject to such option or otherwise  available  for
     purchase by the optionee.

               (ii) The  second  installment  equal to an  additional  one-
     third of the total  option  shares  shall  become  exercisable  on the
     second anniversary of the grant date, provided optionee attends all of
     the regularly-scheduled Board meetings held during the one-year period
     measured from the first  anniversary  of the grant date. To the extent
     that optionee attends less than all of such meetings, the option shall
     lapse as to the number of shares  determined by multiplying  one-third
     of the total option  shares by a fraction,  the  numerator of which is
     the number of such  meetings  which the optionee did not attend during
     the  applicable  one-year  period and the  denominator of which is the
     total  number of such  meetings  held during such  period.  Any option
     shares as to which the  option  lapses  shall no longer be  subject to
     such option or otherwise available for purchase by the optionee.

               (iii) The third  installment equal to the final one-third of
     the  total  option  shares  shall  become  exercisable  on  the  third
     anniversary of the grant date,  provided  optionee  attends all of the
     regularly-scheduled  Board  meetings  held during the one-year  period
     measured from the second  anniversary of the grant date. To the extent
     that optionee attends less than all of such meetings, the option shall
     lapse as to the number of shares  determined by multiplying  one-third
     of the total option  shares by a fraction,  the  numerator of which is
     the number of such  meetings  which the optionee did not attend during
     the  applicable  one-year  period and the  denominator of which is the
     total  number of such  meetings  held during such  period.  Any option
     shares as to which the  option  lapses  shall no longer be  subject to
     such option or otherwise available for purchase by the optionee.

     As the  option  becomes  exercisable  for one or more  installments  of the
option shares,  the installments  shall accumulate,  and the option shall remain
exercisable  for the  accumulated  installments  until the  expiration or sooner
termination of the option term.

         b. Annual  Grant.  Each annual  option  grant under  Paragraph B of the
Grant Dates section shall become  exercisable in its entirety one (1) year after
the grant date, provided optionee attends all of the  regularly-scheduled  Board
meetings held during that one-year  period.  To the extent that optionee attends
less than all of such  meetings,  the  option  shall  lapse as to the  number of
shares  determined  by  multiplying  the  number  of total  option  shares  by a
fraction,  the  numerator  of which is the  number  of such  meetings  which the
optionee  did  not  attend  during  the  applicable   one-year  period  and  the
denominator  of which is the total  number of such  meetings  held  during  such
period.  Any  option  shares as to which the  option  lapses  shall no longer be
subject to such option or otherwise  available for purchase by the optionee.  To
the extent the option becomes exercisable for one or more

                                       6.

<PAGE>


option shares,  such option shall remain  exercisable  for such shares until the
expiration or sooner termination of the option term.

         c. Special  Grant.  Provided the optionee  continues as a Board Member,
any special  automatic option grant made to that individual under Paragraph C of
the Grant Dates section (the "Special Option") shall become  exercisable for the
option shares in accordance with the following provisions:

               -  One-third  of  the  total  option   shares  shall  become
     exercisable  upon the later of (i) the first  anniversary of the grant
     date of his or her initial automatic option grant under Paragraph A of
     the Grant Dates  section  ("the Initial Grant Date") or (ii) the grant
     date of the Special Option, provided that in either event the optionee
     attended all of the regularly-scheduled Board meetings held during the
     one-year  period  measured  from the Initial Grant Date. To the extent
     that  optionee  attended  less than all of such  meetings,  the option
     shall  immediately  lapse as to the  number  of shares  determined  by
     multiplying  one-third of the total option  shares by a fraction,  the
     numerator of which is the number of such  meetings  which the optionee
     did not attend  during such  one-year  period and the  denominator  of
     which is the total  number of such  meetings  held during that period.
     Any  option  shares as to which the option  lapses  shall no longer be
     subject to such  option or  otherwise  available  for  purchase by the
     optionee.

               - An  additional  one-third of the total option shares shall
     become  exercisable  upon the later of (ii) the second  anniversary of
     the Initial  Grant Date or (ii) the grant date of the Special  Option,
     provided  optionee  attended  all  of  the  regularly-scheduled  Board
     meetings  held  during the  one-year  period  measured  from the first
     anniversary  of the Initial  Grant Date.  To the extent that  optionee
     attended less than all of such meetings,  the option shall immediately
     lapse as to the number of shares  determined by multiplying  one-third
     of the total option  shares by a fraction,  the  numerator of which is
     the number of such  meetings  which the optionee did not attend during
     the  applicable  one-year  period and the  denominator of which is the
     total  number of such  meetings  held during such  period.  Any option
     shares as to which the  option  lapses  shall no longer be  subject to
     such option or otherwise available for purchase by the optionee.

               - The final  one-third  of the  total  option  shares  shall
     become  exercisable upon the later of (i) the third anniversary of the
     Initial  Grant  Date or (ii)  the  grant  date of the  Special  Grant,
     provided  optionee  attended  all  of  the  regularly-scheduled  Board
     meetings  held during the  one-year  period  measured  from the second
     anniversary  of the Initial  Grant Date.  To the extent that  optionee
     attended less than all of such meetings,  the option shall immediately
     lapse as to the number of shares determined by multiplying

                                       7.

<PAGE>


     one-third of the total option  shares by a fraction,  the numerator of
     which is the number of such meetings which the optionee did not attend
     during the applicable  one-year period and the denominator of which is
     the total number of such meetings held during such period.  Any option
     shares as to which the  option  lapses  shall no longer be  subject to
     such option or otherwise available for purchase by the optionee.

         For any  special  option  grant made under  Paragraph  C.1 of the Grant
Dates section to an individual who did not in fact receive an initial  automatic
option grant on the original  effective date of the Plan, the foregoing schedule
shall be adjusted so that the term "Initial  Grant Date" shall mean the original
January 28, 1992 effective date of the Plan, even though such individual did not
receive an initial automatic option grant at that time.

         As the Special Option becomes  exercisable for one or more installments
of the option shares, the installments shall accumulate,  and the Special Option
shall remain  exercisable for the accumulated  installments until the expiration
or sooner termination of the option term.

     d.  Term.  Each  outstanding  option  under the Plan held by an  individual
serving  as a  non-employee  Board  Member on  January  1, 1997 and each  option
granted under the Plan on or after January 1, 1997 shall have a term of ten (10)
years  measured  from the  automatic  grant  date,  whether or not the  optionee
continues  to  serve  as a Board  Member,  subject  to  earlier  termination  in
connection  with a Corporate  Transaction  or Hostile Take- Over as  hereinafter
provided.

3.       Exercise of Option.

         Upon exercise of the option,  the option price for the purchased shares
shall  become  immediately  payable in one of the  alternative  forms  specified
below:

               (i) cash or check payable to the Corporation's order; or

               (ii)  shares of Common  Stock held by the  optionee  for the
     requisite  period  necessary  to avoid a charge  to the  Corporation's
     reported  earnings  and  valued  at Fair  Market  Value on the date of
     exercise; or

               (iii) any  combination of the foregoing so long as the total
     payment equals the aggregate option price for the purchased shares; or

               (iv)  payment  effected  through  a  broker-dealer  sale and
     remittance  procedure pursuant to which the Optionee (I) shall provide
     irrevocable instructions to a Corporation-designated  broker-dealer to
     effect the  immediate  sale of the  purchased  shares and remit to the
     Corporation,  out of the sale  proceeds  available  on the  settlement
     date, an amount equal to the

                                       8.

<PAGE>


     aggregate  option  price  payable  for the  purchased  shares plus all
     applicable  Federal and State income and employment  taxes required to
     be withheld by the  Corporation  by reason of such  purchase  and (II)
     shall   provide   directives  to  the   Corporation   to  deliver  the
     certificates for the purchased shares directly to such broker-dealer.

4.       Limited-Transferability.

         The option may, in  connection  with the  optionee's  estate  plan,  be
assigned  in whole or in part  during  the  optionee's  lifetime  to one or more
members of the optionee's immediate family or to a trust established exclusively
for one or more such family members.  The assigned portion may only be exercised
by the  person or  persons  who  acquire a  proprietary  interest  in the option
pursuant to the assignment.  The terms  applicable to the assigned portion shall
be the  same as  those  in  effect  for the  option  immediately  prior  to such
assignment  and shall be set forth in such  documents  issued to the assignee as
the Corporation may deem appropriate.  Should the optionee die while holding the
option,  then that option shall be transferred in accordance with the optionee's
will or the laws of descent and distribution.

5.       Effect of Termination of Board Membership.

         a. Should the optionee  cease to serve as a Board Member for any reason
(other than death) while  holding an  automatic  option grant under this Article
II, then such  optionee  shall have until the  expiration  of the ten  (10)-year
option  term in which to  exercise  such  option for any or all of the shares of
Common Stock for which the option is exercisable at the time of such  optionee's
cessation of Board  service.  However,  the option shall,  immediately  upon the
optionee's  cessation of service as a Board  Member,  terminate  and cease to be
outstanding  for any and all shares of Common  Stock for which the option is not
otherwise at that time exercisable.

         b. Should an optionee  die while  serving as a Board  Member,  then any
outstanding  automatic  grant held by the  optionee  at the time of death may be
subsequently exercised, for any or all of the shares at the time subject to that
option, by the personal representative of the optionee's estate or by the person
or persons to whom the option is transferred  pursuant to the optionee's will or
in accordance with the laws of descent and distribution. The option shall remain
so exercisable until the expiration of the ten (10)-year option term.

         c. Each  automatic  option  grant shall  terminate  and cease to remain
exercisable  for  any of the  option  shares  upon  the  expiration  of the  ten
(10)-year  option  term,  subject  to  earlier   termination  upon  a  Corporate
Transaction or Hostile Take-Over as hereinafter provided.

                                       9.

<PAGE>


         d. For purposes of the Plan, the optionee shall be deemed to serve as a
Board  Member  for so long as he or she  continues  to serve as a member  of the
Board or  Directors  or as a member of the board of  directors  of any Parent or
Subsidiary of the Corporation.

6.       Stockholder Rights.

         An option  holder shall have none of the rights of a  stockholder  with
respect to any shares covered by the automatic grant until such individual shall
have  exercised  the  option,  paid the  option  price  and been  issued a stock
certificate for the purchased shares.

7.       Remaining  Terms.  The remaining terms and conditions of each automatic
option grant shall be as set forth in the prototype  Non-Statutory  Stock Option
Agreement attached as Exhibit A to the Plan.

CORPORATE TRANSACTION

     A.  In  the  event  of  any  of  the  following  transactions   ("Corporate
Transaction"):

               (i) a merger or  consolidation  in which the  Corporation is
     not the  surviving  entity,  except for a  transaction  the  principal
     purpose  of  which  is  to  change  the  State  of  the  Corporation's
     incorporation; or

               (ii) a sale of all or substantially all of the Corporation's
     assets in complete liquidation or dissolution of the Corporation; or

               (iii) any  reverse  merger in which the  Corporation  is the
     surviving  entity  but in which all of the  Corporation's  outstanding
     voting  stock  is   transferred   to  the  acquiring   entity  or  its
     wholly-owned subsidiary;

                  then each automatic option grant at the time outstanding under
the Plan and not  otherwise at the time fully  exercisable  shall  automatically
accelerate  so that each such option shall,  immediately  prior to the specified
effective  date for the Corporate  Transaction,  become fully  exercisable  with
respect  to the total  number of shares of Common  Stock at the time  subject to
such  option  and may be  exercised  for  all or any  portion  of  such  shares.
Immediately  following  the  consummation  of such  Corporate  Transaction,  all
outstanding options under this Plan shall terminate and cease to be exercisable,
except to the extent assumed by the successor corporation or its parent company.

                  B. To the extent one or more options  understanding  under the
Plan at the time of the  Corporate  Transaction  are  assumed  by the  successor
corporation or its parent company, then each of those options shall, immediately
after such Corporate Transaction, be appropriately adjusted to apply and pertain
to the number and class of securities which would have been issued to the option
holder in the consummation of such Corporate

                                       10.

<PAGE>


Transaction had that option been exercised  immediately  prior to such Corporate
Transaction.  Appropriate  adjustments  shall also be made to the  option  price
payable per share, provided the aggregate option price shall remain the same.

                  C. The automatic  grants in effect under this Plan shall in no
way affect the right of the  Corporation  to adjust,  reclassify,  reorganize or
otherwise  change its capital or business  structure  or to merge,  consolidate,
dissolve,  liquidate  or sell or  transfer  all or any part of its  business  or
assets.

CHANGE IN CONTROL/HOSTILE TAKEOVER

                  A. Each automatic option grant  outstanding  under the Plan at
the  time  of a  Change  in  Control  of  the  Corporation  shall  automatically
accelerate  so that each such option shall,  immediately  prior to the specified
effective date for the Change in Control,  become fully exercisable with respect
to the total number of shares of Common Stock at the time subject to such option
and may be exercised  for all or any portion of such shares at any time prior to
the expiration or sooner termination of the option term.

                  B. Upon the occurrence of a Hostile Take-Over,  each automatic
option  grant at the time  outstanding  under the Plan  shall  automatically  be
cancelled in return for a cash  distribution  from the  Corporation in an amount
equal to the excess of (i) the Take-Over  Price of the shares of Common Stock at
the time subject to the cancelled option (whether or not the option is otherwise
at the time exercisable for such shares) over (ii) the aggregate  exercise price
payable for such shares.  The cash  distribution  payable upon such cancellation
shall  be  made  to the  option  holder  within  five  (5)  days  following  the
consummation  of the  Hostile  Take-Over.  Stockholder  approval  of  this  1997
restatement  of  the  Plan  shall   constitute   pre-approval   of  each  option
subsequently  granted  with  such a  automatic  cancellation  provision  and the
subsequent cancellation of that option in accordance with the provisions of this
Paragraph B. No  additional  approval of the Board shall be required at the time
of the actual option cancellation and cash distribution.

                  C. For purposes of this Article II, the following  definitions
shall be in effect:

                           A Change in Control shall be deemed to occur if:

                                   (i)  any  person  or  related  group  of
     persons  (other  than the  Corporation  or a person  that  directly or
     indirectly  controls,  is  controlled  by, or is under common  control
     with,  the  Corporation)  directly or indirectly  acquires  beneficial
     ownership (within the meaning of Rule 13d-3 of the Securities Exchange
     Act of 1934) of securities possessing more than forty percent (40%) of
     the  total  combined  voting  power of the  Corporation's  outstanding
     securities pursuant to a tender or exchange offer made directly to the
     Corporation's stockholders; or

                                       11.

<PAGE>


                                   (ii)   there   is  a   change   in   the
     composition of the Board over a period of twenty-four (24) consecutive
     months or less such that a majority of the Board  members  ceases,  by
     reason  of one or more  proxy  contests  for  the  election  of  Board
     members, to be comprised of individuals who either (A) have been Board
     members  continuously  since the  beginning of such period or (B) have
     been elected or nominated  for election as Board  members  during such
     period by at least two-thirds of the Board members described in clause
     (A) who were still in office at the time such  election or  nomination
     was approved by the Board.

                           A Hostile  Take-Over shall be deemed to occur in
     the event any  person or  related  group of  persons  (other  than the
     Corporation  or a person that  directly  or  indirectly  controls,  is
     controlled  by, or is under  common  control  with,  the  Corporation)
     directly  or  indirectly  acquires  beneficial  ownership  (within the
     meaning  of Rule  13d-3  of the  Securities  Exchange  Act of 1934) of
     securities  possessing  more  than  forty  percent  (40%) of the total
     combined  voting  power of the  Corporation's  outstanding  securities
     pursuant  to  a  tender  or  exchange   offer  made  directly  to  the
     Corporation's  stockholders  which the Board does not  recommend  such
     stockholders to accept.

                           The Take-Over Price per share shall be deemed to
     be equal to the greater of (a) the Fair Market  Value per share on the
     date of the option  cancellation or (b) the highest reported price per
     share paid in effecting such Hostile Take-Over.

                  D. The shares of Common Stock subject to each option cancelled
in connection  with the Hostile  Take-Over shall not be available for subsequent
issuance under this Plan.

                                       12.

<PAGE>


                                   ARTICLE III

                            MISCELLANEOUS PROVISIONS

AMENDMENT OF THE PLAN

                  The  Board  shall  have  complete  and  exclusive   power  and
authority to amend or modify the Plan in any or all respects.  However,  no such
amendment or modification shall adversely affect any rights and obligations with
respect to any stock options at the time  outstanding  under the Plan unless the
optionee  consents to such  amendment  or  modification.  In  addition,  certain
amendments  may require  stockholder  approval  pursuant to  applicable  laws or
regulations.

EFFECTIVE DATE AND TERM OF PLAN

                  A. The Plan was  adopted  by the  Board in  December  1991 and
approved by the  Corporation's  stockholders  in January  1992.  The Plan became
effective  on January 28,  1992,  the date when the Common  Stock  first  became
subject  to the  registration  requirements  of  Section  12 of  the  Securities
Exchange Act of 1934.  The Plan was  subsequently  amended on March 31, 1992. On
May 24, 1994, the Plan was restated, subject to stockholder approval at the 1995
Annual  Meeting,  to (i) increase  the maximum  number of shares of Common Stock
authorized for issuance  under the Plan by an additional  200,000  shares,  (ii)
increase the number of shares for which an initial  automatic option grant is to
be made under  Paragraph A of the Grant  Dates  section  from  23,810  shares to
40,000  shares and the number of shares  for which the annual  automatic  option
grants are to made  under  Paragraph  B of the Grant  Dates  section  from 2,858
shares to 3,000 shares each,  (iii)  provide for a special  40,000-share  option
grant to each non-employee Board member upon his or her subsequent  cessation of
affiliate  status with any venture  capital fund or other  investment  entity or
corporate  partner  with  which  he or she was  affiliated  at the time the Plan
originally  became effective on January 28, 1992 or which required him or her to
transfer to such entity the economic  benefit of any previous  option  grants to
such  individual  and (iv)  effect  certain  additional  changes  to the Plan to
clarify the  benefits  available  to  participants.  Nothing in the May 24, 1994
restatement  shall have any effect or impact upon any prior  option  grants made
under the Plan,  and those prior option grants shall  continue to be governed by
the terms and provisions of the option agreements evidencing those grants.

                  B. The Plan was amended and restated by the Board on March 19,
1997 (the "1997 Restatement") to effect the following changes:  (i) increase the
maximum  number of shares of Common Stock  authorized for issuance over the term
of the Plan from 342 858 shares to 592,858 shares,  (ii) allow each  outstanding
option  under the Plan held by an  individual  serving as a  non-employee  Board
Member on January  1, 1997 and each  option  granted  under the Plan on or after
January 1, 1997 to remain  outstanding  as to any otherwise  exercisable  option
shares for the full ten  (10)-year  option  term,  whether  or not the  optionee
continues to serve as a Board Member, and (iii) effect a series of changes to

                                       13.

<PAGE>


the provisions of the Plan (including the stockholder approval  requirements) in
order to take advantage of the recent amendments to Rule 16b-3 of the Securities
and Exchange Commission which exempts certain officer and director  transactions
under  the  Plan  from  the  short-swing  liability  provisions  of the  federal
securities laws. The 1997 Restatement is subject to stockholder  approval at the
1997 Annual Meeting, and no option grants made on the basis of the 250,000-share
increase shall become  exercisable in whole or in part unless and until the 1997
Restatement is approved by the  stockholders.  Should such stockholder  approval
not be  obtained,  then any  options  granted on the basis of the  250,000-share
increase shall terminate without ever becoming exercisable for those shares, and
no further option grants shall be made on the basis of such share  increase.  In
addition,  all options  outstanding  under the Plan on or after  January 1, 1997
will remain subject to a maximum twelve (12)-month exercise period following the
optionee's  cessation  of Board  service.  In the  absence  of such  stockholder
approval,  option  grants  shall,  however,  continue to be made pursuant to the
provisions  of the  Automatic  Option  Grant  Program  in effect  under the Plan
immediately prior to the 1997  Restatement.  All option grants made prior to the
1997  Restatement  shall remain  outstanding  in  accordance  with the terms and
conditions of the respective  instruments  evidencing those options, and nothing
in the 1997 Restatement  (other than the extension of the post-service  exercise
period) shall be deemed to modify or in any way affect those outstanding options
or issuances.

                  C. The Plan shall  terminate upon the earliest to occur of (i)
December 2, 2001 unless sooner  terminated by the Board,  (ii) the date on which
all shares available for issuance under the Plan shall have been issued pursuant
to the  exercise of the  automatic  grants made  hereunder  or (iii) the date on
which all  outstanding  options are  cashed-out in  connection  with the Hostile
Takeover  provisions of the Plan. If the date of termination is determined under
clause (i) above,  then any option grants  outstanding on such date shall not be
affected  by the  termination  of the Plan and shall  continue to have force and
effect in accordance  with the  provisions of the  instruments  evidencing  such
grants.

CASH PROCEEDS

                  Any cash proceeds received by the Corporation from the sale of
shares  pursuant to the  automatic  grants made under the Plan shall be used for
general corporate purposes.

REGULATORY APPROVALS

                  The  implementation  of the Plan,  the  granting of any option
hereunder, and the issuance of Common Stock upon the exercise of any such option
shall be subject to the  Corporation's  procurement of all approvals and permits
required  by  regulatory  authorities  having  jurisdiction  over the Plan,  the
options granted under it and the Common Stock issued pursuant to it.

                                       14.

<PAGE>


NO IMPAIRMENT OF RIGHTS

                  Nothing in this Plan or any  automatic  grant made pursuant to
the Plan  shall  be  construed  or  interpreted  so as to  affect  adversely  or
otherwise  impair the right of the Corporation or its stockholders to remove any
optionee from service on the Board at any time in accordance with the provisions
of applicable law.

                                       15.

<PAGE>


                                    EXHIBIT A










                                  Exhibit 99.8

<PAGE>


                                                          AUTOMATIC OPTION GRANT


                           MATRIX PHARMACEUTICAL, INC.

                      NON-STATUTORY STOCK OPTION AGREEMENT


                  AGREEMENT made this ________ day of ____________,  199_ by and
between Matrix Pharmaceutical,  Inc., a corporation organized and existing under
the laws of the State of Delaware (the "Company"), and _________________________
(the "Optionee").

                                   WITNESSETH:

RECITALS

                  A. The Company's  Board of Directors (the "Board") has adopted
the Company's  1991  Director  Stock Option Plan (the "Plan") for the purpose of
providing an equity  incentive for individuals to serve as non-employee  members
of the Board.

                  B. Optionee is a non-employee  Board member who is entitled to
receive an option to acquire  shares of the Company's  common  stock,  par value
$0.01 per share (the "Common  Stock"),  pursuant to the  automatic  option grant
program  implemented  for  non-employee  Board  members  under  the  Plan.  This
Agreement is executed pursuant to, and is intended to carry out the purposes of,
the Plan in  connection  with the  automatic  option grant made to such Optionee
thereunder.

                  C. The granted option is intended to be a non-statutory  stock
option  which does not satisfy the  requirements  of Section 422 of the Internal
Revenue Code.

                  D. For purposes of this Agreement,  the following  definitions
shall be in effect:

         Board  Member:  The Optionee  shall be deemed to be a Board Member
     for so long as such  individual  continues to serve as a member of the
     Company's Board of Directors (the "Board") or as a member of the board
     of directors of any Parent or Subsidiary Corporation.

         Fair Market Value: The Fair Market Value per share of Common Stock
     on any date in question  shall be determined  in  accordance  with the
     following provisions:



<PAGE>


               (i) If the Common  Stock is not at the time listed or admitted to
     trading on any stock exchange but is traded on the Nasdaq National  Market,
     then the Fair Market Value shall be the closing  selling price per share of
     Common  Stock on the date in  question,  as such price is  reported  by the
     National  Association of Securities  Dealers,  Inc. on the Nasdaq  National
     Market or any successor  system.  If there is no reported  closing  selling
     price  for the  Common  Stock on the  date in  question,  then the  closing
     selling price on the last preceding  date for which such  quotation  exists
     shall be determinative of Fair Market Value.

               (ii) If the Common  Stock is at the time  listed or  admitted  to
     trading on any stock  exchange,  then the Fair  Market  Value  shall be the
     closing  selling price per share of Common Stock on the date in question on
     the stock exchange  serving as the primary market for the Common Stock,  as
     such price is officially  quoted on such exchange.  If there is no reported
     sale of Common  Stock on such  exchange on the date in  question,  then the
     Fair Market Value shall be the closing selling price on the exchange on the
     last preceding date for which such quotation exists.

         Parent  Corporation:  A  corporation  shall  be  deemed  to be a Parent
     Corporation if it is one of the corporations (other than the Company) in an
     unbroken chain of corporations ending with the Company,  provided each such
     corporation  (other than the Company)  owns, at the time of  determination,
     stock  possessing  fifty percent (50%) or more of the total combined voting
     power of all  classes  of stock in one of the  other  corporations  in such
     chain.

         Subsidiary  Corporation:   A  corporation  shall  be  deemed  to  be  a
     Subsidiary  Corporation  if it is one of the  corporations  (other than the
     Company) in an unbroken chain of  corporations  beginning with the Company,
     provided  each such  corporation  (other than the last  corporation  in the
     unbroken chain) owns, at the time of determination,  stock possessing fifty
     percent (50%) or more of the total combined  voting power of all classes of
     stock in one of the other corporations in such chain.

TERMS

                  1. Grant of Option. On ____________,  199_ (the "Grant Date"),
there is hereby automatically granted to Optionee, pursuant to the provisions of
the Plan,  a stock  option to purchase up to 3,000  shares of Common  Stock (the
"Option  Shares") upon the terms and  conditions set forth in this Agreement and
in the Plan, and such terms and  conditions of the Plan are hereby  incorporated
into this Agreement by reference and made a part hereof as if expressly included
in this  Agreement.  The Option Shares shall be purchasable  in accordance  with
such terms and conditions at the option  exercise price of $__________ per share
(the "Option Price").

                                       2.


<PAGE>


                  2.  Option  Term.  This  option  shall have a term of ten (10)
years measured from the Grant Date and shall accordingly  expire at the close of
business on _______________________, 200_ (the "Expiration Date"), unless sooner
terminated in accordance with Paragraph 7A or 7C of this Agreement.

                  3. Limited  Transferability.  This option,  together  with the
special stock  appreciation  right under  Paragraph 7C, may, in connection  with
Optionee's  estate  plan,  be  assigned  in whole or in part  during  Optionee's
lifetime to one or more  members of  Optionee's  immediate  family or to a trust
established  exclusively  for one or more  such  family  members.  The  assigned
portion may only be exercised by the person or persons who acquire a proprietary
interest in the option pursuant to the assignment.  The terms  applicable to the
assigned portion shall be the same as those in effect for the option immediately
prior to such  assignment.  Any  other  attempt  to  assign,  pledge,  transfer,
hypothecate   or  otherwise   dispose  of  this  option  or  the  special  stock
appreciation  right  during  Optionee's  lifetime,  and any  levy of  execution,
attachment or similar  process on this option or such stock  appreciation  right
shall be null and void. Should the Optionee die while holding this option,  then
this option shall be transferred in accordance  with Optionee's will or the laws
of inheritance and distribution.

                  4.  Exercisability.  This option shall become  exercisable  in
accordance  with the terms of  attached  Exhibit  I. Once  this  option  becomes
exercisable  for one or more Option Shares in  accordance  with Exhibit I, those
Option Shares shall accumulate, and this option shall remain exercisable for the
accumulated Option Shares until the Expiration Date or sooner termination of the
option term under Paragraph 7A or 7C.

                  5. Cessation of Board Membership. Should the Optionee cease to
serve as a Board Member  while this option is  outstanding,  then the  following
provisions shall become applicable:

                         (i)  Should  the  Optionee's  service  as a  Board
     Member  terminate for any reason other than death while this option is
     outstanding, then Optionee shall have until the Expiration Date of the
     option  term to exercise  this option for any Option  Shares for which
     this  option is  exercisable  on the date of such  cessation  of Board
     service.  However, this option shall,  immediately upon the Optionee's
     cessation  of service  as a Board  Member,  terminate  and cease to be
     outstanding with respect to any Option Shares for which this option is
     not  otherwise  at  that  time  exercisable  in  accordance  with  the
     provisions of this Agreement.

                         (ii) Should the  Optionee  die while  serving as a
     Board  Member,  then the  personal  representative  of the  Optionee's
     estate (or the  person or  persons  to whom the option is  transferred
     pursuant  to the  Optionee's  will or in  accordance  with the laws of
     inheritance) shall have the

                                       3.

<PAGE>


     right to exercise  this option for any or all of the Option  Shares at
     the time  subject to such  option.  Such right shall  lapse,  and this
     option shall cease to be exercisable,  upon the Expiration Date of the
     option term.

                         (iii) In no event may this option be exercised for
     any Option  Shares after the specified  Expiration  Date of the option
     term or the sooner  termination  of this option under  Paragraph 7A or
     7C.

                  6.       Adjustment in Option Shares.

                  A.  In the  event  any  change  is made  to the  Common  Stock
issuable  under  the  Plan  by  reason  of  any  stock  split,  stock  dividend,
combination  of  shares,  exchange  of  shares  or other  change  affecting  the
outstanding   Common  Stock  as  a  class  without  receipt  of   consideration,
appropriate  adjustments shall  automatically be made to the number and/or class
of  securities  subject to this option and the Option Price payable per share in
order  to  reflect  such  transaction  and  thereby  preclude  the  dilution  or
enlargement of benefits hereunder.

                  B. If this  option is assumed in  connection  with a Corporate
Transaction  under Paragraph 7, then this option shall,  immediately  after such
Corporate  Transaction,  be  appropriately  adjusted to apply and pertain to the
number and class of  securities  which would have been issued to Optionee in the
consummation  of such  Corporate  Transaction  had this  option  been  exercised
immediately prior to such Corporate Transaction.  Appropriate  adjustments shall
also be made to the Option  Price  payable  per share,  provided  the  aggregate
Option Price shall remain the same.

                  7.       Corporate   Transaction/Change   in   Control/Hostile
                           Take-Over.

                  A.  In the  event  of any of  the  following  transactions  (a
"Corporate Transaction"):

                         (i) a merger or  acquisition  in which the Company
     is not the surviving  entity,  except for a transaction  the principal
     purpose   of  which  is  to  change   the   State  of  the   Company's
     incorporation, or

                         (ii) a sale  of  all or  substantially  all of the
     Corporation's  assets in complete  liquidation  or  dissolution of the
     Corporation; or

                         (iii) any  reverse  merger in which the Company is
     the  surviving  entity but in which all of the  Company's  outstanding
     voting  stock  is   transferred   to  the  acquiring   entity  or  its
     wholly-owned subsidiary;

                                       4.

<PAGE>


                  the   exercisability   of  this  option  shall   automatically
accelerate  so that  such  option  shall,  immediately  prior  to the  specified
effective  date for the Corporate  Transaction,  become fully  exercisable  with
respect to all the Option  Shares at the time  subject to this option and may be
exercised  for all or any  portion of such  shares.  Immediately  following  the
consummation of the Corporate Transaction, this option shall terminate and cease
to be outstanding,  except to the extent assumed by the successor corporation or
its parent company.

                  B. In  connection  with any Change in Control of the  Company,
the  exercisability of this option shall  automatically  accelerate so that such
option shall,  immediately prior to the specified  effective date for the Change
in Control,  become fully  exercisable  with respect to all the Option Shares at
the time subject to this option and may be  exercised  for all or any portion of
such shares.  The option as so accelerated  shall remain  exercisable  until the
expiration  or sooner  termination  of the option  term.  For  purposes  of this
Agreement, a Change in Control shall be deemed to occur in the event:

                         (i) any person or related group of persons  (other
     than the Company or a person that directly or indirectly controls,  is
     controlled by, or is under common control with, the Company)  directly
     or indirectly  acquires  beneficial  ownership  (within the meaning of
     Rule 13d-3 of the  Securities  Exchange  Act of 1934,  as  amended) of
     securities  possessing  more  than  forty  percent  (40%) of the total
     combined voting power of the Company's outstanding securities pursuant
     to  a  tender  or  exchange  offer  made  directly  to  the  Company's
     stockholders; or

                         (ii) there is a change in the  composition  of the
     Board over a period of  twenty-four  (24)  consecutive  months or less
     such that a majority of the Board members ceases,  by reason of one or
     more proxy contests for the election of Board members, to be comprised
     of  individuals  who either (A) have been Board  members  continuously
     since  the  beginning  of such  period  or (B) have  been  elected  or
     nominated for election as Board members during such period by at least
     two-thirds of the Board members described in clause (A) who were still
     in office at the time such election or nomination  was approved by the
     Board.

                  C. Should a Hostile Take-Over of the Company occur at any time
while this  option is  outstanding,  then this  option  shall  automatically  be
cancelled  upon the effective  date of such Hostile  Take-Over in exchange for a
cash  distribution  from the Company.  Such  distribution  shall be in an amount
equal to the excess of (i) the Take-Over  Price of the shares of Common Stock at
the time  subject  to this  option  (whether  or not the  option  is at the time
otherwise  exercisable for such shares) over the aggregate  Option Price payable
for such  shares.  The cash  distribution  shall  be made  within  five (5) days
following the effective  date of the Hostile  Take-Over,  and no approval of the
Board shall be required

                                       5.

<PAGE>


in connection  with such  cancellation  and  distribution.  For purposes of this
Paragraph 7C, the following definitional provisions shall be in effect:

                  A Hostile Take-Over shall be deemed to occur in the event
     (i) any person or related group of persons  (other than the Company or
     a person that directly or indirectly controls, is controlled by, or is
     under  common  control  with,  the  Company)  acquires   ownership  of
     securities  possessing  more  than  forty  percent  (40%) of the total
     combined voting power of the Company's outstanding securities pursuant
     to  a  tender  or  exchange  offer  made  directly  to  the  Company's
     stockholders  which the Board does not recommend such  stockholders to
     accept.

                  The Take-Over Price per share shall be deemed to be equal
     to the greater of (a) the Fair Market  Value per share of Common Stock
     on the date of the option  cancellation  or (b) the  highest  reported
     price per share paid by the acquiring  entity in effecting the Hostile
     Take-Over.

                  D. This Agreement shall not in any way affect the right of the
Company to adjust,  reclassify,  reorganize  or  otherwise  make  changes in its
capital or business structure or to merge, consolidate,  dissolve,  liquidate or
sell or transfer all or any part of its business or assets.

                  8. Privilege of Stock  Ownership.  Optionee shall not have any
stockholder rights with respect to the Option Shares until such individual shall
have  exercised the option,  paid the Option Price for the purchased  shares and
been issued a stock certificate for such shares.

                  9.       Manner of Exercising Option.

                  A. In order to  exercise  this  option for one or more  Option
Shares for which this  option is at the time  exercisable,  Optionee  (or in the
case of exercise after Optionee's death, the Optionee's executor, administrator,
heir or legatee, as the case may be) must take the following actions:

                         (i) Execute and  deliver to the  Secretary  of the
     Company a written  notice  of  exercise  (the  "Exercise  Notice")  in
     substantially the form of Exhibit II attached hereto.

                         (ii)  Pay  the  aggregate  Option  Price  for  the
     purchased shares in one or more of the following alternative forms:

                                   - full  payment  in cash or  check  made
          payable to the Company's order;

                                       6.

<PAGE>

                                   - full payment in shares of Common Stock
          held by the Optionee for the requisite  period necessary to avoid
          a  charge  to the  Company's  earnings  for  financial  reporting
          purposes and valued at Fair Market Value on the Exercise Date;

                                   -  full  payment  in  a  combination  of
          shares of Common Stock held for the requisite period necessary to
          avoid a charge to the Company's earnings for financial  reporting
          purposes and valued at Fair Market Value on the Exercise Date and
          cash or check; or

                                   -  full  payment   through  a  sale  and
          remittance  procedure  pursuant to which the  Optionee  (a) shall
          provide   irrevocable   instructions   to  a   Company-designated
          brokerage  firm to effect  the  immediate  sale of the  purchased
          shares  and  remit  to the  Company,  out of  the  sale  proceeds
          available on the settlement  date,  sufficient funds to cover the
          aggregate exercise price payable for the purchased shares and (b)
          shall  concurrently  provide directives to the Company to deliver
          certificates  for the purchased shares directly to such brokerage
          firm in order to complete the sale transaction.

                         (iii)   Furnish   to   the   Company   appropriate
     documentation  that the  person or persons  exercising  the option (if
     other than Optionee) have the right to exercise this option.

                  B. For purposes of this Agreement,  the Exercise Date shall be
the date on which the Exercise  Notice shall have been delivered to the Company.
Except to the extent the sale and remittance  procedure  specified  above may be
utilized in connection  with the exercise of this option,  payment of the Option
Price for the purchased shares must accompany such notice.

                  C. As soon as  practical  after the exercise of this option in
accordance  with the  provisions  of this  Agreement,  the Company shall mail or
deliver  to or on  behalf  of the  Optionee  (or any  other  person  or  persons
exercising this option) a stock certificate representing the purchased shares.

                  D. In no event may this option be exercised for any fractional
shares.

                  10.  Legality of Issuance.  The Company shall not be obligated
to sell or issue any Option  Shares  pursuant to this  Agreement if such sale or
issuance  might,  in the  opinion  of the  Company  and the  Company's  counsel,
constitute a violation by the Company of any applicable law or regulation.

                                       7.

<PAGE>

                  11. Binding  Effect.  Subject to the  limitations set forth in
Paragraph 3 of this Agreement, this Agreement shall be binding upon and inure to
the benefit of the executors, administrators,  heirs, legal representatives, and
successors and assigns of the parties hereto;  provided,  however, that Optionee
may not assign any of  Optionee's  rights  under  this  Agreement  other than as
permitted under Paragraph 3.

                  12. No Impairment of Rights.  Nothing in this  Agreement or in
the Plan  shall be  deemed to impair or  otherwise  restrict  the  rights of the
Company or its  stockholders  to remove the Optionee  from the Board at any time
pursuant to the provisions of applicable law. 

                  13.  Governing  Law. This  Agreement  shall be governed by and
construed in accordance  with the laws of the State of California  applicable to
contracts entered into and wholly to be performed within the State of California
by California residents.

                  14. Notices.  All notices and other  communications under this
Agreement  shall be in  writing.  Unless and until the  Optionee  is notified in
writing to the contrary,  all notices,  communications and documents directed to
the Company shall, if not personally delivered,  be mailed to the Company at the
following address:

                                    Matrix Pharmaceutical, Inc.
                                    34700 Campus Drive
                                    Fremont, CA  94555

                  Unless  and until the  Company is  notified  in writing to the
contrary,  all notices,  communications  and documents intended for the Optionee
shall, if not personally  delivered,  be mailed to Optionee's last known address
as shown on the Company's books.  Notices and communications  shall be mailed by
registered mail,  return receipt  requested,  postage prepaid.  All mailings and
deliveries related to this Agreement shall be deemed received only when actually
received,  unless properly mailed by registered mail, return receipt  requested,
in which event they shall be deemed received two days after the date of mailing.

                  15.  Construction.  This  Agreement  and the option  evidenced
hereby are issued pursuant to the automatic grant program for non-employee Board
Members in effect  under the Plan and shall be subject to the express  terms and
provisions of the Plan applicable to such automatic grants.

                                       8.

<PAGE>



                  IN WITNESS  WHEREOF,  Matrix  Pharmaceutical,  Inc. has caused
this Agreement to be executed on its behalf by its  duly-authorized  officer and
the Optionee has executed  this  Agreement,  all on the day and year first above
written.


                                         MATRIX PHARMACEUTICAL, INC.

                                         By:____________________________________

                                         Title:_________________________________

                                         _______________________________________
                                                        OPTIONEE

                                         Address:_______________________________

                                         _______________________________________

                                       9.

<PAGE>


                                    EXHIBIT I

                                EXERCISE SCHEDULE

                  The option shall become  exercisable  in  accordance  with the
following terms and conditions,  provided the Optionee continues in service as a
Board Member.

                  The option shall become exercisable for all of the Option
     Shares  one (1) year  after  the Grant  Date,  provided  the  Optionee
     attends all of the regularly-scheduled Board meetings held during that
     one-year period. To the extent that the Optionee attends less than all
     of such  meetings,  this option shall lapse as to the number of Option
     Shares  determined by multiplying the total number of Option Shares by
     a fraction,  the numerator of which is the number of such meetings not
     attended by the Optionee during the applicable one-year period and the
     denominator  of which is the total number of such meetings held during
     that period. Any Option Shares as to which this option so lapses shall
     no  longer  be  subject  to such  option or  otherwise  available  for
     purchase by the Optionee.

                  In no event  shall  this  option  become  exercisable  for any
additional  Option Shares  following the date the Optionee  ceases to serve as a
Board Member.


<PAGE>

                                   EXHIBIT II


                       NOTICE OF EXERCISE OF STOCK OPTION


                  I hereby notify Matrix  Pharmaceutical,  Inc. (the  "Company")
that I elect to purchase  _______________  shares of the Company's  Common Stock
(the "Purchased  Shares") pursuant to that certain option (the "Option") granted
to me on to purchase up to 3,000  shares of such Common Stock at an option price
of $ _________________ per share (the "Option Price").

                  Concurrently  with the delivery of this Exercise Notice to the
Secretary of the Company, I shall hereby pay to the Company the Option Price for
the Purchased  Shares in accordance with the provisions of my agreement with the
Company  evidencing the Option and shall deliver whatever  additional  documents
may be required by such agreement as a condition for exercise.  Alternatively, I
may utilize the special broker-dealer sale and remittance procedure specified in
my agreement to effect the payment of the Option Price for the Purchased Shares.


_________________________                       ________________________________
Date                                            Optionee

                                    Address:    ________________________________

                                                ________________________________


  Print name in exact manner
  it is to appear on the
  stock certificate:                            ________________________________
                                                                                
                                                ________________________________
                                                                                
                    


  Address to which  certificate
  is to be sent, if different
  from address  above:                          ________________________________
                                                                                
                                                ________________________________

  Social Security Number:                       ________________________________
                                                                                



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