MATRIX PHARMACEUTICAL INC/DE
DEFR14A, 1997-05-27
PHARMACEUTICAL PREPARATIONS
Previous: MICRO FOCUS GROUP PUBLIC LIMITED COMPANY, 6-K, 1997-05-27
Next: BUTTREY FOOD & DRUG STORES CO, S-8, 1997-05-27




                                  SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
           Proxy Statement Pursuant to Section 14(a) of the Securities
                              Exchange Act of 1934

         Filed by the registrant [X]

         Filed by a party other than the registrant [ ]

         Check the appropriate box:
         [ ] Preliminary Proxy Statement
                                                    [ ] Confidential,  for   Use
                                                        of the  Commission  Only
                                                        (as  permitted  by  Rule
                                                        14a-6(e)(2))
         [X] Definitive Proxy Statement

         [X] Definitive Additional Materials

         [ ] Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                           Matrix Pharmaceutical, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)


                           Matrix Pharmaceutical, Inc.
- --------------------------------------------------------------------------------
      (Name of Person(s) Filing Proxy Statement, if other than Registrant)

Payment of Filing Fee (Check the appropriate box):
         [X] No fee required.
         [ ] Fee computed on table  below  per  Exchange  Act Rules  14a-6(i)(1)
             and 0-11.

         (1) Title of each class of securities to which transaction applies:
- --------------------------------------------------------------------------------
         (2) Aggregate number of securities to which transactions applies:
- --------------------------------------------------------------------------------
         (3) Per unit price or other  underlying  value of transaction  computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee
is calculated and state how it was determined):
- --------------------------------------------------------------------------------
         (4) Proposed maximum aggregate value of transaction:
- --------------------------------------------------------------------------------
         (5) Total fee paid:
- --------------------------------------------------------------------------------
         [ ] Fee paid previously with preliminary materials.
- --------------------------------------------------------------------------------
         [ ] Check box if any part of the fee is offset as  provided by Exchange
Act Rule  0-11(a)(2)  and identify the filing for which the  offsetting  fee was
paid previously.  Identify the previous filing by registration statement number,
or the form or schedule and the date of its filing.

         (1) Amount Previously Paid:
- --------------------------------------------------------------------------------
         (2) Form, Schedule or Registration Statement No.:
- --------------------------------------------------------------------------------
         (3) Filing Party:
- --------------------------------------------------------------------------------
         (4) Date Filed:
- --------------------------------------------------------------------------------

<PAGE>

                           MATRIX PHARMACEUTICAL, INC.
                               34700 CAMPUS DRIVE
                            FREMONT, CALIFORNIA 94555
                                  MAY 23, 1997


Dear Stockholder:

     You are  cordially  invited to attend the  Annual  Meeting of  Stockholders
("Annual Meeting") of Matrix Pharmaceutical, Inc. (the "Company"), which will be
held at 10:00 A.M. on June 25, 1997, at the Company's headquarters, 34700 Campus
Drive, Fremont, California 94555.

     At the  Annual  Meeting,  you will be asked to  consider  and vote upon the
following proposals: 


         (i) to elect a Board of five directors to serve for the ensuing year or
     until their successors are duly elected and qualified;

         (ii) to approve a series of amendments to the Company's 1988 Restricted
     Stock Plan (the "Plan"), including (i) an increase in the maximum number of
     shares  of  common  stock  authorized  for  issuance  under  the Plan by an
     additional  2,000,000 shares and (ii) the extension of the term of the Plan
     from September 2, 1998 to December 31, 2002;

         (iii) to approve a series of amendments to the Company's 1991 Directors
     Stock  Option Plan (the  "Directors  Plan"),  including  an increase in the
     maximum number of shares of common stock  authorized for issuance under the
     Directors Plan by an additional 250,000 shares; and

         (iv) to ratify the  appointment  of Ernst & Young LLP as the  Company's
     independent accountants for the fiscal year ending December 31, 1997.

     The  enclosed  Proxy  Statement  more fully  describes  the  details of the
business to be conducted at the Annual Meeting.

     After  careful   consideration,   the  Company's  Board  of  Directors  has
unanimously approved the proposals and recommends that you vote IN FAVOR OF each
such proposal.


     After reading the Proxy Statement, please mark, date, sign and return by no
later than June 16, 1997,  the  enclosed  proxy card in the  accompanying  reply
envelope.  If you  decide  to attend  the  Annual  Meeting,  please  notify  the
Secretary of the Company that you wish to vote in person and your proxy will not
be voted. YOUR SHARES CANNOT BE VOTED UNLESS YOU MARK, DATE, SIGN AND RETURN THE
ENCLOSED PROXY, OR ATTEND THE ANNUAL MEETING IN PERSON.


     Copies  of  the  Matrix   Pharmaceutical,   Inc.   1996  Annual  Report  to
Stockholders  as well as the  Company's  Annual  Report  on Form  10-K  are also
enclosed.

     We look forward to seeing you at the Annual Meeting.

                                                Sincerely,


                                                Craig R. McMullen,
                                                President  and  Chief  Executive
                                                Officer

                                    IMPORTANT

     Please  mark,  date,  sign and return the  enclosed  proxy  promptly in the
accompanyng postage-paid return envelope so that if you are unable to attend the
Annual Meeting your shares may be voted.


<PAGE>


                           MATRIX PHARMACEUTICAL, INC.
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                                  JUNE 25, 1997

TO THE STOCKHOLDERS OF MATRIX PHARMACEUTICAL, INC.:

     NOTICE IS HEREBY  GIVEN that the Annual  Meeting of  Stockholders  ("Annual
Meeting")  of  Matrix   Pharmaceutical,   Inc.,  a  Delaware   corporation  (the
"Company"),  will be held at 10:00 A.M. local time on Wednesday,  June 25, 1997,
at the Company's  headquarters,  34700 Campus Drive, Fremont,  California 94555,
for the following  purposes: 

         1. To elect a Board of five  directors to serve for the ensuing year or
     until their respective successors are elected and qualified.

         2. To approve a series of amendments to the Company's  1988  Restricted
     Stock Plan (the "Plan"), including (i) an increase in the maximum number of
     shares  of  common  stock  authorized  for  issuance  under  the Plan by an
     additional  2,000,000 shares and (ii) the extension of the term of the Plan
     from September 2, 1998 to December 31, 2002.

         3. To approve a series of amendments to the  Company's  1991  Directors
     Stock  Option Plan (the  "Directors  Plan"),  including  an increase in the
     maximum number of shares of common stock  authorized for issuance under the
     Directors Plan by an additional 250,000 shares.

         4. To ratify  the  appointment  of Ernst & Young  LLP as the  Company's
     independent accountants for the fiscal year ending December 31, 1997.

         5. To  transact  such other  business as may  properly  come before the
     Annual Meeting and any adjournment or adjournments thereof.

     The  foregoing  items of  business  are more fully  described  in the Proxy
Statement accompanying this Notice.

     Stockholders  of  record  at the close of  business  on April 28,  1997 are
entitled  to  receive  notice  of and to  vote  at the  Annual  Meeting  and any
adjournment  thereof. A list of the stockholders  entitled to vote at the Annual
Meeting will be available for  inspection  at the Company's  offices for 10 days
prior to the Annual Meeting.

     All  stockholders  are  cordially  invited to attend  the  Annual  Meeting.
However, to assure your representation at the meeting, please carefully read the
accompanying  Proxy  Statement,  which describes the matters to be voted upon at
the Annual Meeting,  and mark,  date, sign and return the enclosed proxy card in
the reply envelope provided. Should you receive more than one proxy because your
shares are  registered in different  names and  addresses,  each proxy should be
returned to ensure that all your shares will be voted.  If you attend the Annual
Meeting and vote by ballot,  your proxy vote will be revoked  automatically  and
only your vote at the Annual Meeting will be counted.  The prompt return of your
proxy card will assist us in preparing for the Annual Meeting.  


                                             Sincerely,


                                             James R. Glynn, 
                                             Chief Operating Officer,
                                             Chief    Financial    Officer   and
                                             Secretary

Fremont, California
May 23, 1997


     YOUR VOTE IS VERY  IMPORTANT.  PLEASE  READ THE  ATTACHED  PROXY  STATEMENT
CAREFULLY. IF YOU DO NOT EXPECT TO ATTEND IN PERSON, PLEASE COMPLETE, SIGN, DATE
AND RETURN THE ENCLOSED PROXY CARD IN THE  ACCOMPANYING  ENVELOPE AS PROMPTLY AS
POSSIBLE.


<PAGE>
                           MATRIX PHARMACEUTICAL, INC.
                               34700 Campus Drive
                            Fremont, California 94555

                           ---------------------------
                                 PROXY STATEMENT
                           ---------------------------

                     For the Annual Meeting of Stockholders
                           To Be Held on June 25, 1997

                      GENERAL INFORMATION FOR STOCKHOLDERS

     The  enclosed  proxy  ("Proxy")  is  solicited  on  behalf  of the Board of
Directors (the "Board") of Martix  Pharmaceutical,  Inc., a Delaware corporation
(the "Company"), for use at the 1997 Annual Meeting of Stockholders (the "Annual
Meeting")  to be  held  at  10:00  a.m.  on  June  25,  1997,  at the  Comapny's
headquarters,  34700  Campus  Drive,  Fremont,  California  94555,  and  at  any
adjournment thereof.

     This Proxy Statement and the accompanying form of Proxy was first mailed to
the  stockholders  entitled  to vote at the  Annual  Meeting on or about May 23,
1997.

Record Date and Voting

     Stockholders  of record at the close of  business  on April 28,  1997,  are
entitled  to notice  of and to vote at the  Annual  Meeting.  As of the close of
business on such date,  there were  21,269,530  shares of the  Company's  common
stock  (the  "Common  Stock")  outstanding  and  entitled  to vote,  held by 291
stockholders  of  record.  No  shares  of  the  Company's  preferred  stock  are
outstanding.  Each  stockholder is entitled to one vote for each share of Common
Stock  held by such  stockholder  as of the record  date.  If a choice as to the
matters  coming before the Annual Meeting has been specified by a stockholder on
the Proxy, the shares will be voted accordingly.  If no choice is specified, the
shares will be voted IN FAVOR OF the approval of the proposals  described in the
Notice  of  Annual  Meeting  of  Stockholders   and  in  this  Proxy  Statement.
Abstentions and broker non-votes (i.e., the submission of a Proxy by a broker or
nominee specifically  indicating the lack of discretionary  authority to vote on
the matter) are counted for purposes of determining the presence or absence of a
quorum for the transaction of business.  Abstentions will be counted towards the
tabulation  of votes cast on proposals  presented to the  stockholders  and will
have the same effect as negative  votes,  whereas  broker  non-votes will not be
counted for purposes of determining whether a proposal has been approved or not.

     Any  stockholder  or  stockholder's   representative   who,  because  of  a
disability,  may need special assistance or accommodation to allow him or her to
participate  at  the  Annual  Meeting  may  request  reasonable   assistance  or
accommodation from the Company by contacting Peter Dworkin in Investor Relations
in writing at 34700 Campus Drive,  Fremont,  California 94555 or by telephone at
(510) 742-9900. To provide the Company sufficient time to arrange for reasonable
assistance, please submit such requests by June 16, 1997.

Revocability of Proxies

     Any stockholder  giving a Proxy pursuant to this solicitation may revoke it
at any time prior to exercise by filing with the Secretary of the Company at its
principal executive offices at 34700 Campus Drive, Fremont,  California 94555, a
written notice of such revocation or a duly executed Proxy bearing a later date,
or by attending the Annual Meeting and voting in person.

Solicitation

     The  Company  will bear the  entire  cost of  solicitation,  including  the
preparation,  assembly,  printing  and mailing of the Notice of Annual  Meeting,
this Proxy Statement, the Proxy and any additional

                                       1

<PAGE>

solicitation  materials  furnished  to  stockholders.   Copies  of  solicitation
materials  will be furnished to brokerage  houses,  fiduciaries  and  custodians
holding shares in their names that are beneficially owned by others so that they
may forward this solicitation material to such beneficial owners. To assure that
a quorum will be present in person or by proxy at the Annual Meeting,  it may be
necessary  for certain  officers,  directors,  employees  or other agents of the
Company to solicit proxies by telephone,  facsimile or other means or in person.
The Company will not compensate such  individuals  for any such services.  Other
than as  described  above,  the  Company  does not  presently  intend to solicit
proxies other than by mail.

                                    IMPORTANT

     Please mark,  date, sign and return the enclosed Proxy in the  accompanying
postage-prepaid,  return envelope by no later than June 16, 1997, so that if you
are unable to attend the Annual Meeting, your shares may be voted.


     The  Company's  Annual  Report to  Stockholders  for the fiscal  year ended
December 31, 1996 (the "Annual  Report") and the Annual  Report on Form 10-K for
the fiscal  year ended  December  31,  1996,  as filed with the  Securities  and
Exchange  Commission  (the Form 10-K ), have been mailed  concurrently  with the
mailing of the Notice of Annual Meeting and Proxy Statement to all  stockholders
entitled  to notice of and to vote at the  Annual  Meeting.  Neither  the Annual
Report nor the Form 10-K is considered proxy soliciting  material and neither is
incorporated into this Proxy Statement.

                                        2

<PAGE>

                 MATTERS TO BE CONSIDERED AT THE ANNUAL MEETING

                       PROPOSAL ONE--ELECTION OF DIRECTORS


     At the Annual  Meeting,  a Board of five directors will be elected to serve
until the Company's next Annual Meeting,  or until their  successors  shall have
been duly elected and  qualified or until their death,  resignation  or removal.
The Board has selected five nominees,  all of whom are current  directors of the
Company.  Each person nominated for election has agreed to serve if elected, and
management  has no reason to believe  that any nominee  will be  unavailable  to
serve.  Unless  otherwise  instructed,  the Proxy  holders will vote the Proxies
received  by them IN FAVOR OF the  nominees  named  below.  The five  candidates
receiving the highest number of affirmative  votes of all the shares entitled to
vote at the  Annual  Meeting  will be  elected.  If any  nominee is unable to or
declines  to serve as a  director,  the  Proxies  may be voted for a  substitute
nominee designated by the current Board. As of the date of this Proxy Statement,
the Board is not aware of any nominee who is unable or will  decline to serve as
a director.

     Craig R. McMullen, the Company's President and Chief Executive Officer, has
announced his intention to resign and thus not to stand for  re-election  to the
Board of  Directors.  A  committee  of the Board has been formed to search for a
successor to Mr. McMullen.  For the foreseeable future, Mr. McMullen will remain
as Chief Executive Officer.


     The Board recommends that the stockholders vote IN FAVOR OF the election of
each of the  following  nominees to serve as directors of the Company  until the
next Annual Meeting, until their successors have been duly elected and qualified
or until their death, resignation or removel.

Information with Respect to Nominees

   Set forth below is information regarding the nominees.

                                              
                          Position(s) with the           Director
         Name                   Company           Age     Since
- --------------------- -------------------------- ----- ----------
J. Stephan Dolezalek ..... Director                40     1994
Edward E. Luck ........... Chairman of the Board   46     1985
John E. Lyons ............ Director                71     1993
Julius L. Pericola  ...... Director                68     1993
Alan E. Salzman .......... Director                43     1988

Business Experience of Nominees

     Mr.  Dolezalek  has served as a director of the Company since October 1994.
Mr. Dolezalek has been an attorney with the firm of Brobeck,  Phleger & Harrison
LLP,  principal  outside  counsel to the  Company,  since  1984,  and has been a
partner in that firm since 1989.

     Mr. Luck, a co-founder of the Company, has held the position of Chairman of
the Board since 1989.  From 1985 to 1989, he held the positions of President and
Chief Executive  Officer of the Company.  Prior to founding the Company,  he was
co-founder and President of Cytoscan,  Inc., a cancer screening company.  He was
co-founder,  Vice  President  and  Director  of  Technical  Affairs of  Collagen
Corporation from 1975 to 1979.

     Mr. Lyons has been a director of the Company since  February 1993. He spent
more than 40 years with Merck & Co.,  Inc.,  most recently as Vice Chairman from
1988 to his  retirement  as an  officer  in 1991.  In  addition,  he  served  as
Executive Vice President of Merck & Co., Inc. from 1985 to 1988 and as Corporate
Senior Vice  President and President of Merck,  Sharp & Dohme Division from 1975
to 1985.  Mr. Lyons  currently  serves as a director of Synaptic  Pharmaceutical
Corporation and Immunex Corporation.

     Mr.  Pericola has been a director of the Company  since  January  1993.  He
worked for 40 years  with  Bristol  Myers  Squibb Co.  ("Bristol  Myers"),  most
recently as Executive Vice President of Bristol-Myers  International  Group from
1985 to his retirement as an officer in June 1990.  Mr.  Pericola also served as
Corporate  Senior Vice President of Bristol Myers Company from 1981 to 1990, and
as  President  of the  Bristol  Laboratories  division  from  1975 to 1984.  Mr.
Pericola  is  currently a director of  Fujisawa  U.S.A.,  Inc.  and a trustee of
Syracuse Research Corporation and Syracuse University.

                                        3

<PAGE>

     Mr.  Salzman has been a director of the Company since 1988. Mr. Salzman has
been a managing  general  partner of VantagePoint  Venture  Partners since March
1995. Mr. Salzman was a general  partner of Canaan Venture  Partners,  L.P. from
June 1988 through February 1995. From 1984 to 1988, he was a partner of Brobeck,
Phleger &  Harrison  LLP,  the  Company's  principal  outside  counsel.  He is a
director of one privately held company.

Number of Directors; Relationships

     The  Company's  Bylaws  authorize  the Board to fix the number of directors
serving on the Board,  provided that such number shall not be less than five nor
more than nine. The number of directors is currently fixed at seven. Immediately
prior to the Annual  Meeting,  the number of directors  will be reduced to five.
All  directors  hold office until the next annual  meeting of  stockholders,  or
until their successors shall have been duly elected and qualified or until their
earlier death,  resignation  or removal.  Officers are appointed to serve at the
discretion of the Board.

     There are no family  relationships among executive officers or directors of
the Company.

Board Meetings and Committees

     The Board held five meetings and took action by unanimous  written  consent
on two occasions  during the fiscal year ended  December 31, 1996. The Board has
an Audit  Committee and a Compensation  Committee,  but does not have a standing
Nominating   Committee.   Each  director,   except  Mr.  Murdock,   attended  or
participated  in at least 75% of the  aggregate  number of meetings of the Board
and the Board  Committees on which such  director  served which were held during
1996.

     The Audit  Committee is primarily  responsible  for  approving the services
performed by the Company's independent  accountants and reviewing reports of the
Company's  internal and external  auditors  regarding the  Company's  accounting
practices and systems of internal  accounting  controls.  During the fiscal year
ended December 31, 1996,  the Audit  Committee  consisted of two directors,  Mr.
Lyons and Mr.  Salzman.  The Audit  Committee held one meeting during the fiscal
year ended December 31, 1996, at which both members were in attendance.

     The  Compensation  Committee  reviews and  approves the  Company's  general
compensation  policies,  sets  compensation  levels for the Company's  executive
officers and  administers  the Company's  1988  Restricted  Stock Plan and other
employee (and officer) benefit  programs.  During the fiscal year ended December
31, 1996, the Compensation  Committee  consisted of two directors,  Mr. Pericola
and Mr. Salzman. The Compensation  Committee met seven times for the fiscal year
ended December 31, 1996, at which both members were in attendance.  Furthermore,
the  Compensation  Committee  took action by  unanimous  written  consent on one
occasion during the fiscal year ended December 31, 1996.

Director Compensation

     The  non-employee  Board members do not receive any cash  compensation  for
their  service  on the  Board  or any  Committee  of the  Board.  However,  such
individuals  are reimbursed for travel  expenses  incurred in attending Board or
Committee meetings.

     Each  non-employee  Board member will receive an automatic option grant for
40,000 shares of Common Stock under the Company's  1991  Directors  Stock Option
Plan  (the  "Directors  Plan")  on the date of his or her  initial  election  or
appointment to the Board.  Each such initial grant will become  exercisable  for
one-third  of the shares upon the  optionee's  completion  of each year of Board
service over the three-year  period measured from the grant date.  However,  the
option will become  immediately  exercisable for all of the option shares if the
optionee dies or becomes  disabled  during his or her period of Board service or
if the Company is acquired  by merger or asset sale or if there  should  occur a
change in control of the Company through a successful tender offer for more than
40% of the Company's outstanding Common Stock or a change in the majority of the
Board effected through one or more contested elections for Board membership.  In
addition,  on the date of each  Annual  Stockholders  Meeting,  each  individual
re-elected as a non-employee Board member will receive an automatic option grant
for an additional  3,000 shares of Common Stock,  provided such  individual  has
served as a Board member

                                        4

<PAGE>

for at least six months.  Each such annual option grant will become  exercisable
for all the option  shares upon the  optionee's  completion of one year of Board
service  measured  from  the  grant  date,   subject  to  acceleration  upon  an
acquisition of the Company by merger or asset sale or other change in control of
the  Company.  All options  under the  Directors  Plan have a maximum term of 10
years,  subject to earlier  termination  upon the optionee's  cessation of Board
service.  Upon the successful completion of a hostile tender offer for more than
40% of the Company's  outstanding Common Stock, each automatic option grant will
be  canceled,  and the  non-employee  Board  member  will be  entitled to a cash
distribution from the Company based upon the tender-offer price.

     At the 1996  Annual  Stockholders  Meeting  held on May 16,  1996,  Messrs.
Dolezalek, Luck, Lyons, Murdock, Pericola and Salzman each received an automatic
stock option grant under the Directors  Plan for 3,000 shares of Common Stock in
connection  with their  re-election as  non-employee  Board  members.  Each such
option has an  exercise  price of $26.00 per share,  the fair  market  value per
share of Common Stock on the grant date.

                                        5

<PAGE>

       PROPOSAL TWO--APPROVAL OF AMENDMENTS TO 1988 RESTRICTED STOCK PLAN

Introduction

     The  stockholders  are being asked to approve a series of amendments to the
Company's 1988 Restricted Stock Plan (the "Plan") that will effect the following
changes:  (i) increase the number of shares of Common Stock  issuable  under the
Plan by an  additional  2,000,000  shares,  (ii) render the  non-employee  Board
members  eligible to receive option grants and direct stock  issuances under the
Discretionary Option Grant and Stock Issuance Programs in effect under the Plan,
(iii) remove  certain  restrictions  on the  eligibility of  non-employee  Board
members to serve as Plan Administrator,  (iv) allow unvested shares issued under
the Plan and  subsequently  repurchased by the Company at the option exercise or
direct  issue  price  paid per  share to be  re-issued  under  the Plan  through
subsequent  option grants or direct  issuances,  (v) extend the term of the Plan
from  September  2,  1998 to  December  31,  2002  and (vi)  effect a series  of
additional  changes to the  provisions of the Plan  (including  the  stockholder
approval  requirements,  the  transferability of non-statutory stock options and
the  elimination of the six-month  holding period  requirement as a condition to
the  exercise of stock  appreciation  rights) in order to take  advantage of the
recent amendments to Rule 16b-3 of the Securities and Exchange  Commission which
exempts  certain  officer  and  director  transactions  under  the Plan from the
short-swing liability provisions of the federal securities laws.

     The proposed share increase will assure that a sufficient reserve of Common
Stock is  available  under  the Plan in  order  for the  Company  to  provide  a
comprehensive  equity incentive program for the Company's  officers,  employees,
non-employee Board members and independent consultants which will encourage such
individuals  to remain in the  Company's  service and more  closely  align their
interests with those of the  stockholders.  The remaining  amendments which form
part  of this  Proposal  will  enhance  the  Company's  opportunity  to  provide
additional  equity  incentives  to attract and retain the  services of qualified
non-employee   Board  members  and  will  facilitate  plan   administration   by
eliminating a number of limitations  and  restrictions  previously  incorporated
into the Plan to comply with the applicable requirements of SEC Rule 16b-3 prior
to its recent amendment.

     The Plan was  originally  adopted by the Board of Directors on September 2,
1988, and the stockholders  approved the Plan on February 28, 1989. The Plan has
been  subsequently  amended and restated on April 28,  1992,  March 15, 1994 and
December 14, 1995 to increase the number of shares authorized for issuance under
the Plan, and those  restatements  were approved by the  stockholders on May 11,
1993,  May 24, 1994 and May 16,  1996,  respectively.  The new  amendments  were
adopted by the Board on March 19, 1997,  subject to stockholder  approval at the
Annual Meeting.  The affirmative  vote of a majority of the Common Stock present
or  represented  by Proxy at the  Annual  Meeting  and  entitled  to vote on the
Proposal is required for approval of the amendments.

     The terms and  provisions of the Plan,  as amended  through March 19, 1997,
are described more fully below. The description,  however, is not intended to be
a complete  exposition  of all the terms of the Plan. A copy of the Plan will be
furnished  by the  Company  to  any  stockholder  upon  written  request  to the
Secretary of the Company at the Company's headquarters in Fremont, California.

Plan Structure

     The Plan is divided into two separate components:

     Option Grant Program. Officers,  employees,  non-employee Board members and
independent  consultants  may, at the discretion of the plan  administrator,  be
granted options to purchase shares of Common Stock at an exercise price not less
than 85% of the fair market  value of the option  shares on the grant date.  The
granted options may be either  incentive stock options that are designed to meet
the  requirements of Section 422 of the Internal  Revenue Code or  non-statutory
stock  options not  intended to satisfy  such  requirements.  In  addition,  the
granted  options  may include  stock  appreciation  rights  which will allow the
holders to surrender  those  options for payments  from the Company based on the
appreciation in the market value of the Common Stock over the period the options
are outstanding.

                                        6

<PAGE>

     Stock Issuance Program. Officers, employees, non-employee Board members and
independent  consultants  may be granted the right to purchase  shares of Common
Stock at fair  market  value or at  discounts  of up to 15%.  Shares may also be
issued as a bonus for past  services,  without any cash payment  required of the
participant.

Administration

     The  Plan  is  currently   administered  by  the   Compensation   Committee
("Committee").  The  Committee  has full  authority  to  determine  the eligible
individuals to whom option and stock appreciation right grants are to be made or
to whom shares are to be directly issued,  the number of shares to be covered by
each such grant or issuance,  the maximum  term for which any granted  option or
stock  appreciation right is to remain  outstanding,  the time or times at which
the granted options or stock  appreciation  rights are to become  exercisable or
the issued shares are to vest,  and all the other terms and conditions of awards
under the Plan. In addition,  the Committee has full authority to accelerate the
exercisability of outstanding options and to terminate the Company's outstanding
repurchase  rights  with  respect to  unvested  shares,  all upon such terms and
conditions as it deems  appropriate.  All expenses incurred in administering the
Plan will be paid by the Company.

Eligibility

     The  persons  eligible  to  participate  in the  Plan  are  limited  to (i)
employees  (including  officers),  (ii) the non-employee Board members and (iii)
independent  consultants  in  the  service  of the  Company  or  its  parent  or
subsidiary  corporations  (whether  now existing or  subsequently  established).
Non-employee  Board members are also eligible to receive automatic option grants
under the 1991 Directors Stock Option Plan. As of March 31, 1997,  approximately
181 individuals  (including  nine officers of the Company and five  non-employee
Board members) were eligible to participate in the Plan.

Share Reserve

     The maximum  number of shares of the Common Stock issuable over the term of
the Plan may not  exceed  4,630,953  shares  (net of 238,095  shares  previously
canceled and retired from the Plan), including the 2,000,000-share  increase for
which stockholder approval is sought as part of this Proposal No. 2. Such shares
will be made available either from the Company's  authorized but unissued Common
Stock or from Common Stock reacquired by the Company.

     The maximum number of shares for which any one individual  participating in
the Plan may be granted stock options, separately exercisable stock appreciation
rights and direct stock issuances may not exceed 750,000 shares in the aggregate
over the term of the Plan. However, for purposes of this limitation,  any option
grants,  stock  appreciation  rights or direct  stock  issuances  made  prior to
December 31, 1993 will not be taken into account.

     Should an option be terminated or canceled for any reason prior to exercise
or  surrender  in full  (including  options  canceled  in  accordance  with  the
cancellation-regrant  provisions  described  below),  the shares  subject to the
portion of the option not so exercised  or  surrendered  will be  available  for
subsequent  grant.  Unvested  shares  issued  under  the Plan  and  subsequently
repurchased  by the Company,  at the option  exercise or direct issue price paid
per share,  pursuant to the Company's  repurchase  rights under the Plan will be
added  back  to  the  share  reserve  and  will  accordingly  be  available  for
reissuance. However, shares subject to any stock option surrendered or cancelled
in connection with the stock  appreciation right provisions of the Plan will not
be available for subsequent issuance.

     As of March 31, 1997,  approximately  1,919,378 shares of Common Stock were
subject to outstanding  options under the Plan,  and 2,200,462  shares of Common
Stock (including the 2,000,000 shares which are subject to stockholder  approval
as part of this Proposal) were available for issuance under future option grants
and  stock  issuances.  Furthermore,  as  of  March  31,  1997,  749,208  shares
(including 238,095 that have previously been canceled and retired from the Plan)
have been issued  under the Plan.  As of March 31, 1997,  the  weighted  average
exercise  price payable per share upon the exercise of  outstanding  options was
$7.40. The expiration dates for all such outstanding  options range from October
12, 1998 to March 19, 2007.

                                        7

<PAGE>

Changes in Capitalization

     In the event any change is made to the Common Stock issuable under the Plan
(by  reason  of  any  stock  dividend,   stock  split,  combination  of  shares,
recapitalization,  or other change  affecting the outstanding  Common Stock as a
class without the Company's receipt of consideration),  appropriate  adjustments
will be made to (i) the aggregate  number  and/or class of securities  available
for issuance under the Plan, (ii) the maximum number and class of securities for
which any one participant may be granted stock options,  separately  exercisable
stock appreciation  rights and direct stock issuances in the aggregate under the
Plan and (iii) the number and/or class of securities  and the price per share in
effect under each outstanding  option and stock  appreciation  right in order to
prevent the dilution or enlargement of benefits thereunder.

Valuation

     For  purposes of  establishing  the option  exercise  price or direct issue
price and for all other valuation purposes under the Plan, the fair market value
per share of Common Stock on any relevant date will be the closing selling price
per share as reported on the Nasdaq National  Market.  As of March 31, 1997, the
fair  market  value per share of the  Common  Stock was  $6.375  per  share,  as
reported on the Nasdaq National Market.

Terms of Option Grant Program

     Price and Exercisability. The exercise price per share may not be less than
85% of the fair market value per share of Common Stock on the grant date, and no
option may be outstanding for more than a 10-year term. If the granted option is
intended  to be an  incentive  stock  option  under the  Federal  tax laws,  the
exercise  price must not be less than 100% of the fair market value per share of
the Common Stock on the grant date.

     The  exercise  price is  payable  in cash or in  shares  of  Common  Stock.
Optionees are also permitted to exercise the option through a broker-dealer sale
and  remittance  procedure  which will allow the optionee to exercise the option
and sell the  purchased  shares  on the same  day,  with a  portion  of the sale
proceeds  utilized  to satisfy the  exercise  price  payable  for the  purchased
shares. The Committee may also assist any optionee (including an officer) in the
exercise  of the  option  by (i)  authorizing  a loan from the  Company  or (ii)
permitting the optionee to pay the exercise price in installments  over a period
of years. The terms and conditions of any such deferred payment arrangement will
be established by the Committee in its sole discretion,  but in no event may the
maximum  credit  extended to the optionee  exceed the aggregate  exercise  price
payable for the purchased shares (less the par value of those shares),  plus any
federal and state income or employment  taxes  incurred in  connection  with the
purchase.  The Committee may determine that one or more loans may be forgiven in
whole or in part over the individual s period of service with the Company.

     The vesting  schedule for each  granted  option will be  determined  by the
Committee and will be set forth in the  instrument  evidencing  such grant.  The
granted  option  may be (i)  immediately  exercisable  for vested  shares,  (ii)
immediately  exercisable for unvested shares subject to the Company's repurchase
rights,  or  (iii)  exercisable  in  installments  for  vested  shares  over the
optionee's period of service.

     Options are generally not assignable or transferable  other than by will or
the laws of inheritance,  and, during the optionee's lifetime, the option may be
exercised  only by such  optionee.  However,  the Plan  Administrator  may allow
non-statutory  options to be  transferred  or  assigned  during  the  optionee's
lifetime to one or more members of the optionee's immediate family or to a trust
established  exclusively for one or more such family members, to the extent such
transfer or assignment is in furtherance of the optionee's estate plan.

     Stock Appreciation Rights. At the discretion of the Committee,  options may
be granted with stock appreciation rights. A stock appreciation right grants the
holder  the  right  to  surrender  the  underlying  option  for an  appreciation
distribution  from the  Company  equal in amount  to the  excess of (i) the fair
market  value (on the of exercise  date) of the shares of Common  Stock in which
the  optionee is at the time vested under the  surrendered  option over (ii) the
aggregate option exercise price payable for those shares.

                                        8

<PAGE>

The  appreciation  distribution may be made, at the discretion of the Committee,
either in  shares of Common  Stock  valued at fair  market  value on the  option
surrender date or in cash or in a combination of cash and Common Stock.

     Limited stock appreciation rights may be granted to one or more officers of
the  Company  subject to the  short-swing  profit  restrictions  of the  Federal
securities  laws. In the event that more than 50% of the  Company's  outstanding
voting  stock were to be  acquired  pursuant  to a hostile  tender  offer,  each
outstanding option with such a limited right would automatically be canceled, to
the extent such option was at the time exercisable for vested shares.  In return
for the canceled option (or canceled portion),  the officer would receive a cash
distribution  from the Company  based upon the tender  offer  price  payable per
share of vested Common Stock subject to the canceled option.

     Prior to September  1991,  options  were granted  under the Plan to certain
executive officers which included a different form of limited stock appreciation
right. These particular options provide the option holder, if such individual is
an  officer  at the time  that a  hostile  tender  offer  for 25% or more of the
Company's outstanding voting securities is successfully completed, with a 30-day
period in which to surrender the underlying  option for a cash distribution from
the Company  based on the tender offer price payable per vested share subject to
the surrendered option.

     Cancellation  and New Grant of Options.  The Committee has the authority to
effect,  at any time  and from  time to  time,  the  cancellation  of any or all
options  outstanding  under the Plan and to grant in  substitution  therefor new
options  covering  the same or  different  numbers of shares of Common Stock but
with an exercise  price per share not less than 85% of the fair market value per
share of the Common Stock on the new grant date.

     Termination  of  Service  and  Repurchase  Rights.  All  options  and stock
appreciation rights granted under the Plan will terminate upon the expiration of
the 12-month  period (or such shorter  period as the  Committee may establish at
the time of grant) measured from the date of the optionee's cessation of service
with the Company.  In the event of the optionee's  death, the option will remain
exercisable  until  the first  anniversary  of the  optionee's  death and may be
exercised  by the personal  representative  of the  optionee's  estate or by the
person  inheriting  the option.  However,  each option will only be  exercisable
during the applicable  post-service exercise period for the number of shares (if
any)  for  which  such  option  is  exercisable  at the  time of the  optionee's
cessation of service, unless the Committee determines at such time to accelerate
the exercisability of the option in whole or in part.

     Unvested  shares of Common Stock  acquired upon the exercise of one or more
options will be subject to  repurchase  by the Company,  at the original  option
exercise price paid per share, upon the optionee's cessation of service prior to
vesting in those shares.  The Committee has complete  discretion in establishing
the  terms  and  conditions  upon  which  such  repurchase   rights  are  to  be
exercisable,  including the  establishment of appropriate  vesting schedules and
other provisions for the expiration of such rights in one or more installments.

     The Committee will have complete  discretion to extend the period following
the  optionee's  termination  of  service  during  which his or her  outstanding
options may be exercised and/or to accelerate the exercisability of such options
or vesting of his or her unvested  shares in whole or in part.  Such  discretion
may be  exercised  at any time while the  options  remain  outstanding,  whether
before  or after  the  optionee's  actual  cessation  of  service.  In no event,
however, may an option be exercised after the expiration of the option term.

     For purposes of the Plan, an  individual  will be deemed to continue in the
Company's  service for so long as he or she  renders  services to the Company or
any parent or subsidiary corporation as an employee, a non-employee Board member
or an independent consultant.

Terms of Stock Issuance Program

     Shares may be issued under the stock issuance program directly, without any
intervening  stock option  grant,  in accordance  with the  following  terms and
conditions.

     Issue Price;  Payment.  The purchase  price per share will not be less than
85% of the fair market value per share of Common Stock on the date the Committee
authorizes the issuance. The issue price for

                                        9

<PAGE>

the  purchased  shares may be paid in cash,  in shares of Common Stock valued at
fair market value on the date of issuance,  or by promissory note payable to the
Company's order. The promissory note may, at the discretion of the Committee, be
subject to cancellation  over the  participant's  period of service.  Shares may
also be issued as a bonus for past  services,  without any cash or other payment
required of the participant.

     Vesting Schedule; Restrictions. The interest of a participant in the Common
Stock issued under the Plan may be fully and immediately vested upon issuance or
may  vest  in one or  more  installments  over  the  participant's  service,  as
determined by the Committee. The elements of the vesting schedule, including the
effect disability or death is to have upon vesting,  are to be determined by the
Committee at the time of issuance.

     The  participant  may not sell or transfer  any  unvested  shares of Common
Stock,  other than  permitted  transfers  by gift to certain  family  members or
family trusts. Except for such transfer restrictions,  the participant will have
all  the  rights  of  a  stockholder   with  respect  to  the  unvested  shares.
Accordingly,  the  participant  will have the right to vote such  shares  and to
receive any cash dividends or other  distributions  paid or made with respect to
such shares.

     Surrender of Shares; Repurchase. In the event the participant should, while
his or her  interest  in the  Common  Stock  remains  unvested,  (i)  attempt to
transfer  (other than by  permissible  gift) any  unvested  Common Stock or (ii)
cease  service  with  the  Company,  then the  Company  will  have the  right to
repurchase from such individual,  at the purchase price originally paid for such
shares,  the shares in which he or she has not acquired a vested  interest,  and
such individual  will cease to have any stockholder  rights with respect to such
repurchased shares.

Provisions Applicable to Option Grants and Share Issuances

     Acceleration  of  Vesting.  All  outstanding  options  and  unvested  share
issuances under the Plan will vest on an accelerated  basis upon certain changes
in the ownership or control of the Company. Accordingly, in the event of any one
of the following transactions (a "Corporate Transaction"): 

         (a) a merger or  acquisition  in which the Company is not the surviving
     entity,  except  for a  transaction  the  principal  purpose of which is to
     change the state of incorporation,

         (b) the sale, transfer or other disposition of substantially all of the
     Company's assets in liquidation or dissolution of the Company, or

         (c) any reverse  merger in which the Company is acquired but  continues
     in existence as a separate entity,

     each outstanding option will automatically become exercisable,  immediately
prior to the effective date of the Corporate Transaction,  for all of the option
shares at the time subject to such option and may be exercised for any or all of
those  shares  as  fully-vested  shares.   However,  the  exercisability  of  an
outstanding  option will not so accelerate if and to the extent: (i) such option
is to be assumed by the successor  corporation  (or parent  thereof) or (ii) the
acceleration  of such  option is  subject  to other  limitations  imposed by the
Committee at the time of grant. Immediately following the Corporate Transaction,
each option  outstanding under the Plan will immediately  terminate and cease to
be  exercisable,  except to the extent  assumed by the successor  corporation or
parent thereof.

     The Company's outstanding repurchase rights under both the Option Grant and
Stock  Issuance  Programs will also  terminate,  and the shares subject to those
terminated  rights will become fully  vested,  upon the  Corporate  Transaction,
except  to the  extent  (i)  one or more of  such  repurchase  rights  are to be
assigned  to the  successor  corporation  (or its parent  company)  or (ii) such
termination and accelerated  vesting are precluded by other limitations  imposed
by the Committee at the time the repurchase rights are issued.

     The vesting of options and unvested shares upon a Corporate Transaction may
be seen as an anti-takeover  provision and may have the effect of discouraging a
merger  proposal,  a takeover  attempt or other  efforts to gain  control of the
Company.

     Stockholder  Rights.  No individual is to have any stockholder  rights with
respect to shares  acquired on exercise of an option or under the share issuance
program  until such  individual  has  exercised the option and paid the exercise
price or  purchase  price for the  purchased  shares and has been issued a stock
certificate for the purchased shares.

                                       10

<PAGE>

     Excess Grants. The Plan permits the grant of options to purchase shares and
the  issuance  of shares of Common  Stock in excess of the number of shares then
available for issuance under the Plan. Any option so granted cannot be exercised
and any shares issued must be held in escrow prior to stockholder approval of an
amendment increasing the number of shares available for issuance under the Plan.

Shared Investment Program

     In March 1997, the Committee  authorized a special risk sharing arrangement
to be  implemented  under the Stock  Issuance  Program.  The new  arrangement is
designated  the Shared  Investment  Program (the  "Program")  and will allow the
Company's  officers and other senior  managers the opportunity to acquire shares
of Common  Stock as a  long-term  investment  which  would  further  align their
interests with those of the stockholders.

     Stock Purchase.  Under the Program,  the Company's  executive  officers and
other key managerial  personnel will be given the opportunity to purchase shares
of Common Stock in an individually  designated amount per participant determined
by the Committee. All shares will be purchased at a per share price equal to the
fair market value of the Common Stock on the purchase  date.  The purchase price
will be paid through the  participant's  delivery of a full-recourse  promissory
note payable to Company.  Each note will bear  interest at the minimum per annum
rate, compounded semi-annually, required under the federal tax laws to avoid the
imputation  of  compensation  income and will have a maximum term of nine years.
The note will be secured by a pledge of the purchased shares with the Company.

     Thirty-seven  individuals  are  eligible  to  participate  in the  Program,
including  eight  executive  officers.  If the  stockholders  approve  the share
increase  which  forms  part  of  this  Proposal,   then  the  Program  will  be
implemented,  and it is anticipated that approximately  1,000,000 shares will be
issued under the Program.

     Restrictions  on Transfer.  None of the shares  purchased under the Program
may be sold before the first  anniversary  of the purchase  date,  except in the
event of the  participant's  death or  disability  or the  occurrence of certain
changes in  control of the  Company.  The sale  proceeds  must be applied to the
payment of the principal  portion of the note  attributable  to the shares which
are the  subject  of the sale  plus the  accrued  and  unpaid  interest  on that
principal portion.

     Shares  Investment.  If the  participant  remains in the Company's  service
until the first  anniversary of the purchase date of his or her shares under the
Program,  then the Company will share any loss which the  participant  may incur
upon the subsequent sale of those shares.  The loss sharing  arrangement will be
as follows:

     o   to the extent any shares are sold before the third anniversary of their
         purchase date,  the  participant  will be  responsible  for 100% of the
         loss; and

     o   to the extent any shares are sold on or after the third  anniversary of
         their purchase date, the  participant  will be responsible for only 50%
         of the loss,  and the  Company  will  remit to the  participant  a cash
         payment equal to the remaining 50% of that loss.

     The Company will also be entitled under certain  circumstances  to share in
the gain (if any) which the  participant may realize upon the subsequent sale of
the purchased shares. The gain sharing arrangement will be as follows:

     o   to the extent any of the shares are sold before the second  anniversary
         of their  purchase  date,  the  participant  will only be  entitled  to
         receive 50% of the gain, and the remaining 50% of the gain will be paid
         over to the Company at the time of the sale;

     o   to the  extent  any of the  shares  are  sold on or  after  the  second
         anniversary  but before the third  anniversary  of their purchase date,
         the  participant  will only be entitled to receive 75% of the gain, and
         the  remaining  25% of the gain will be paid over to the Company at the
         time of the sale; and

     o   to the  extent  any of the  shares  are  sold  on or  after  the  third
         anniversary of their purchase date, the participant will be entitled to
         receive 100% of the gain.


                                       11

<PAGE>


     The gain/loss sharing  arrangement will be in effect only to the extent the
shares  are  sold  while  there  is an  outstanding  unpaid  balance  under  the
participant's note and the sale proceeds are applied to payment of that note.

     Termination  of  Service.  If a  participant's  service  with  the  Company
terminates  by  reason  of  death  or  disability  while  his  or  her  note  is
outstanding,  the participant (or the participant's estate in the case of death)
will be deemed to have held the purchased shares until the first  anniversary of
the purchase  date.  The Company will assume 100% of any loss  incurred upon the
sale of those shares, provided such sale occurs while there is an unpaid balance
under the  participant's  note. The  participant  (or his or her estate) will be
entitled to 100% of any gain realized upon the sale of the shares  following his
or her death or disability.

     In the event the  participant's  service  terminates  for any other  reason
after the first  anniversary  of the purchase date,  then the gain/loss  sharing
arrangement  will continue in effect while there remains an  outstanding  unpaid
balance under his or her note.  However,  if such termination  occurs before the
first  anniversary  of the  purchase  date,  then the  participant  will only be
entitled  to 50% of the gain  realized  from any sale of the  shares  made while
there  is an  unpaid  balance  outstanding  on his  or  her  note  and  will  be
responsible for 100% of the loss on any sale of the shares,  whether made before
or after his or her note is paid.

     Should a participant's  service terminate by reason of his or her voluntary
resignation or his or her involuntary  termination,  then that  participant will
have a 6-month period in which to repay his or her note.

     Change of Control.  Immediately  prior to the  consummation  of a change in
control of the Company (whether by merger,  sale of all or substantially  all of
the  Company's  assets  or sale  of  more  than  50% of the  outstanding  voting
securities),  all  restrictions on the sale of the purchased  shares will lapse,
and the  Company  will be  responsible  for 50% of any  loss on the  sale of the
shares, and the participant will be entitled to 100% of any gain.

     Discretionary   Authority.   The  Committee  will  have  the  discretionary
authority to waive any of the transfer  restrictions,  service  requirements  or
holding  period  requirements  otherwise  applicable  to the Program  under such
circumstances as the Committee may deem appropriate.

Amendment and Termination of the Plan

     The Board may amend or modify the Plan in any or all  respects  whatsoever,
subject to any required stockholder approval under applicable law or regulation.

   The Board may terminate the Plan at any time, but in all events the Plan will
terminate upon the earlier of December 31, 2002 or the date all shares available
for issuance under the Plan are issued as vested shares or canceled  pursuant to
the  exercise  or  surrender  of options  granted  under the Plan.  Any  options
outstanding  at the time of the  termination of the Plan will remain in force in
accordance with the provisions of the instruments evidencing such grants.

                                       12

<PAGE>

<TABLE>
Stock Awards

     The table below shows, as to each of the Company's executive officers named
in the Summary  Compensation  Table  elsewhere in this Proxy  Statement  and the
various indicated  individuals and groups,  the number of shares of Common Stock
subject to options  granted under the Plan between January 1, 1996 and March 31,
1997,  together with the weighted  average  exercise price payable per share. No
direct stock issuances have been made to date under the Plan.

                               OPTION TRANSACTIONS
<CAPTION>

                                                                Options Granted 
                                                                 (Number of     Weighted Average
                              Name                                  Shares)      Exercise Price
- -------------------------------------------------------------- ---------------- ----------------
<S>                                                               <C>              <C>   
Craig R. McMullen, President and Chief Executive Officer  .....       --           $   --
James R. Glynn, Chief Operating Officer and Chief Financial
 Officer ......................................................    20,000          $6.375
Andrew G. Korey, Ph.D., Vice President, Medical Information
 and Extramural Scientific Affairs ............................    20,000          $6.375
Richard E. Jones, Ph.D., Vice President, Research and
 Development ..................................................    20,000          $6.375
Dennis M. Brown, Vice President, Discovery Research  ..........    65,000          $11.28
All current executive officers as a group (9 persons)  ........   380,000          $10.17
All current non-employee Board members as a group  ............       --           $   --
All employees, including current officers who are not
 executive officers, as a group (166 persons) .................   910,000          $10.16
</TABLE>

Federal Tax Consequences of Options

     Options granted under the Plan may be either  incentive stock options which
satisfy  the  requirements  of  Section  422 of the  Internal  Revenue  Code  or
non-statutory  options which are not intended to satisfy such requirements.  The
Federal income tax treatment for the two types of options differ as follows:

     Incentive  Options.  No taxable income is recognized by the optionee at the
time of the option grant,  and no taxable income is generally  recognized at the
time the option is exercised.  The optionee  will,  however,  recognize  regular
taxable  income in the year in which the purchased  shares are sold or otherwise
made the subject of  disposition.  For Federal tax  purposes,  dispositions  are
divided into two categories: (i) qualifying and (ii) disqualifying. A qualifying
disposition  occurs if the sale or other  disposition is made after the optionee
has held the shares for more than two years after the option grant date and more
than one year after the exercise date. If either of these two holding periods is
not satisfied, then a disqualifying disposition will result.

     Upon a  qualifying  disposition,  the  optionee  will  recognize  long-term
capital  gain in an amount equal to the excess of (i) the amount  realized  upon
the sale or other  disposition  of the  purchased  shares over (ii) the exercise
price  paid  for the  shares.  If there is a  disqualifying  disposition  of the
shares,  then the  excess of (i) the fair  market  value of those  shares on the
exercise  date over (ii) the exercise  price paid for the shares will be taxable
as ordinary income to the optionee.  Any additional gain or loss recognized upon
the disposition will be recognized as a capital gain or loss by the optionee.

     If the optionee makes a disqualifying  disposition of the purchased shares,
then the Company  will be entitled to an income tax  deduction,  for the taxable
year in which  such  disposition  occurs,  equal to the  excess  of (i) the fair
market value of such shares on the option  exercise  date over (ii) the exercise
price paid for the shares.  In no other  instance  will the Company be allowed a
deduction with respect to the optionee's disposition of the purchased shares.

     Non-Statutory  OptonsS. No taxable income is recognized by an optionee upon
the grant of a  non-statutory  option.  The optionee  will in general  recognize
ordinary income in the year in which the option is exercised equal to the excess
of the fair market value of the  purchased  shares on the exercise date over the
exercise  price paid for those  shares,  and the  optionee  will be  required to
satisfy the tax withholding requirements applicable to such income.

                                       13

<PAGE>

     Special provisions of the Internal Revenue Code apply to the acquisition of
shares  under a non-  statutory  option if the  purchased  shares are subject to
repurchase by the Company or other substantial risk of forfeiture. These special
provisions may be summarized as follows:

         If the shares  acquired upon exercise of the  non-statutory  option are
     subject to repurchase by the Company,  at the original  exercise price paid
     per share, in the event the optionee's  service terminates prior to vesting
     in the shares,  then the optionee will not recognize any taxable  income at
     the time of exercise.  The optionee will have to report as ordinary income,
     as and when the Company's  repurchase right lapses,  an amount equal to the
     difference  between  the fair  market  value of the  shares on the date the
     repurchase  right  lapses  and the  option  exercise  price  paid for those
     shares.

         The optionee  may,  however,  elect under Section 83(b) of the Internal
     Revenue  Code to  include as  ordinary  income in the year of  exercise  an
     amount  equal  to the  difference  between  the  fair  market  value of the
     purchased shares on the date of exercise  (determined as if the shares were
     not  subject to the  Company's  repurchase  right) and the option  exercise
     price paid for the shares.  If the  Section  83(b)  election  is made,  the
     optionee will not recognize any additional income as and when the Company's
     repurchase right lapses.

         The Company will be entitled to a business  expense  deduction equal to
     the amount of ordinary income recognized by the optionee in connection with
     the exercise of the non-statutory  option. The deduction will in general be
     allowed for the taxable year of the Company in which such  ordinary  income
     is recognized by the optionee.

     Stock Appreciation  Rights. An optionee who is granted a stock appreciation
right will recognize ordinary income in the year of exercise equal to the amount
of the appreciation distribution.  The Company will be entitled to an income tax
deduction equal to such  distribution for the taxable year in which the ordinary
income is recognized by the optionee.

     Direct  Stock  Issuance.  The tax  principles  applicable  to direct  stock
issuances  under the Plan  will be  substantially  the same as those  summarized
above for the exercise of non-statutory option grants.

     Deductibility of Executive  Compensation.  The Company anticipates that any
compensation deemed paid by it in connection with disqualifying  dispositions of
incentive stock option shares or exercises of non-statutory options granted with
exercise  prices  equal to the fair market value of the shares on the grant date
will  qualify as  performance-based  compensation  for  purposes of Code Section
162(m) and will not have to be taken into account for purposes of the $1 million
limitation per covered  individual on the deductibility of the compensation paid
to certain executive officers of the Company.

Accounting Treatment

     Option  grants or stock  issuances  with exercise or issue prices less than
the fair market  value of the shares on the grant or issue date will result in a
direct  compensation  expense to the Company's  earnings equal to the difference
between the  exercise or issue price and the fair market  value of the shares on
the grant or issue date.  Such expense will be accruable by the Company over the
period that the option  shares or issued  shares are to vest.  Option  grants or
stock  issuances  with  exercise  or issue  prices not less than the fair market
value of the  shares on the grant or issue  date will not  result in any  direct
charge to the Company's  earnings.  However,  the fair value of those options is
required to be disclosed in the notes to the Company's financial statements, and
the  Company  must also  disclose,  in  pro-forma  statements  to the  Company's
financial  statements,  the impact those  options  would have upon the Company's
reported  earnings  were the value of those options at the time of grant treated
as  compensation  expense.  Whether or not granted at a discount,  the number of
outstanding  options may be a factor in determining  the Company's  earnings per
share on a fully-diluted basis.

     Should one or more  optionees be granted  stock  appreciation  rights which
have no  conditions  upon  exercisability  other  than a service  or  employment
requirement,  then such rights will result in compensation expense to be charged
against the Company's earnings.  Accordingly, at the end of each fiscal quarter,
the amount (if any) by which the fair market value of the shares of common stock
subject to such outstanding stock  appreciation  rights has increased from prior
quarter-end  will be accrued as  compensation  expense,  to the extent such fair
market  value is in excess of the  aggregate  exercise  price in effect for such
rights.

                                       14

<PAGE>

Stockholder Approval

     The affirmative vote of a majority of the outstanding  voting shares of the
Company  present  or  represented  by Proxy and  entitled  to vote at the Annual
Meeting is required  for  approval of the  amendments  to the Plan.  Should such
stockholder  approval not be obtained,  then any stock options granted under the
Plan on the  basis of the  2,000,000-share  increase  which  forms  part of this
Proposal will terminate without ever becoming  exercisable for any of the shares
of Common Stock subject to those options, and no further options will be granted
on the basis of that  increase.  In addition,  non-employee  Board  members will
remain  ineligible to  participate in the  Discretionary  Option Grant and Stock
Issuance Programs under the Plan, and unvested shares repurchased by the Company
will not be available for reissuance under the Plan.  Finally,  the extension of
the term of the Plan from  September  2, 1998 to  December  31, 2002 will not be
implemented.  However,  the Plan will  continue to remain in effect,  and option
grants and  direct  stock  issuance  may  continue  to be made  pursuant  to the
provisions  of the Plan in effect  prior to the  amendments  summarized  in this
Proposal,  until the  available  reserve of Common Stock as last approved by the
stockholders has been issued.

     The Board of Directors  recommends that the  Stockholders  vote IN FAVOR OF
all amendments to the Company's 1988 Restricted Stock Plan.

New Plan Benefits

     No stock option grants or direct stock issuances have been made as of March
31, 1997 under the Plan on the basis of the  2,000,000-share  increase for which
stockholder approval is sought under this Proposal No. 2.

                                       15

<PAGE>

                    PROPOSAL THREE--APPROVAL OF AMENDMENTS TO
                        1991 DIRECTORS STOCK OPTION PLAN

Introduction

     The  stockholders  are being asked to approve a series of amendments to the
Company's  1991  Directors  Stock Option Plan (the  "Directors  Plan") that will
effect the following changes:  (i) increase the number of shares of Common Stock
issuable under the Directors Plan by an additional  250,000  shares,  (ii) allow
each  outstanding  option  held by an  individual  serving as a Board  member on
January 1, 1997 and each subsequently granted option under the Directors Plan to
remain  outstanding  as to any vested option shares for the full 10-year  option
term,  whether or not the optionee  continues  to serve on the Board,  and (iii)
effect a series of additional  changes to the  provisions of the Directors  Plan
(including the stockholder  approval  requirements,  the  transferability of the
options  for estate  planning  purposes  and the  elimination  of the  six-month
holding  period  requirement  as a  condition  to the  exercise  of the  special
cash-out rights provided under the Directors Plan) in order to take advantage of
the recent  amendments to Rule 16b-3 of the Securities  and Exchange  Commission
which exempts certain transactions under the Directors Plan from the short-swing
liability provisions of the federal securities laws.

     The amendments  were adopted by the Board on March 19, 1997 (the "Effective
Date"),  subject  to  stockholder  approval  at the  1997  Annual  Meeting.  The
affirmative  vote of the  holders of a majority of the Common  Stock  present or
represented  by at the Annual  Meeting  and  entitled  to vote is  required  for
approval of the amendments to the Directors Plan.

     The  purpose of the  Directors  Plan is to  promote  the  interests  of the
Company  and its parent or  subsidiary  corporations  by  offering  non-employee
members of the Board of Directors the  opportunity  to  participate in a special
stock option program designed to attract the best possible personnel for service
as directors of the Company and to provide them with  significant  incentives to
remain  in  the  Company's  service.   Accordingly,  the  Board  recommends  the
stockholders vote IN FAVOR OF the amendments.

     The principal terms and provisions of the Directors Plan as modified by the
recent amendments are summarized below. The summary is not, however, intended to
be a complete  description of all the terms of the Directors Plan. A copy of the
Directors Plan as amended will be furnished  without  charge to any  stockholder
upon written request to the Corporate Secretary at the Company's headquarters in
Fremont, California.

Description of the Directors Plan

     Structure.  Under the Directors Plan,  automatic option grants will be made
at periodic  intervals to the non-employee  members of the Board. At the time an
individual  first joins the Board as a non- employee  director,  whether through
election at an Annual Stockholders  Meeting or through appointment by the Board,
that individual will  immediately  receive an automatic  option grant for 40,000
shares  of  Common  Stock,  provided  he or she has not  previously  been in the
Company's employ. At each Annual  Stockholders  Meeting,  each individual who is
re-elected as a non-employee  Board member  (including  individuals who may have
previously  been in the  Company's  employ)  will  automatically  be  granted  a
non-statutory  option to purchase  3,000 shares of Common  Stock,  provided such
individual has been a member of the Board for at least six months.

     A similar  40,000-share  option grant will also be made to any non-employee
Board  member  who  is,  at the  time  he or she  first  joins  the  Board  as a
non-employee  director,   affiliated  with  a  venture  capital  fund  or  other
investment  entity or  corporate  partner  which  requires  that Board member to
transfer to such entity the  economic  benefit of any option  grants which he or
she receives under the Directors Plan. This special  40,000-share  grant will be
made  immediately  upon his or her cessation of such affiliate  status,  and any
individual who receives such a special grant will not be eligible to receive his
or her next 3,000-share annual option grant until the first Annual  Stockholders
Meeting  held  more  than  six  months  after  the  grant  date  of  his  or her
40,000-share option.

     Options  granted under the  Directors  Plan are  non-statutory  options not
intended to satisfy the  requirements  of Section  422 of the  Internal  Revenue
Code.

                                       16

<PAGE>

     Administration.  All grants under the Directors Plan will be made in strict
compliance   with  the  express   provisions  of  the  plan  document,   and  no
administrative  discretion  with respect to such grants will be exercised by the
Board or any committee of the Board.  Stockholder approval of this Proposal will
constitute  pre-approval  of each  option  granted  on or after  the date of the
Annual Meeting pursuant to the provisions of the Directors Plan summarized below
and the subsequent exercise of that option in accordance with those provisions.

     Eligibility.  As of March 31, 1997,  five  non-employee  Board members were
eligible to participate in the Directors Plan.

     Securities  Subject to  Directors  Plan.  The  maximum  number of shares of
Common Stock issuable over the term of the Directors Plan may not exceed 592,858
shares  (including  the  additional  250,000  shares  subject to approval by the
stockholders as part of this Proposal Three). Such share reserve will be subject
to  further  adjustment  in the event of  subsequent  changes  to the  Company's
capital  structure.  The shares may be made available  either from the Company's
authorized  but unissued  Common Stock or from Common  Stock  reacquired  by the
Company, including shares purchased on the open market.

     Should an option  expire or  terminate  for any reason prior to exercise in
full,  the shares  subject to the portion of the option not so exercised will be
available for subsequent grant.

     As of March 31, 1997, options for 228,634 shares were outstanding,  318,366
shares remained available for future grant (assuming stockholder approval of the
proposed  250,000-share  increase),  and 45,858 shares had been issued under the
Directors Plan.

     Exercise  Price.  The option  exercise price per share will be equal to the
fair market  value of the Common  Stock on the  automatic  grant  date.  For all
valuation purposes under the Directors Plan, the fair market value of the Common
Stock on any relevant date will be deemed equal to the closing  selling price of
the Common Stock on that date, as quoted on the Nasdaq National Market. On March
31, 1997, the fair market value per share was $6.375.

     The  exercise  price  may be paid in cash or in  shares  of  Common  Stock.
Options may also be exercised through a same-day sale program, pursuant to which
a designated  brokerage firm effects the immediate sale of the shares  purchased
under  the  option  and  pays  over to the  Company,  out of the  sale  proceeds
available on the settlement  date,  sufficient funds to cover the exercise price
for the purchased shares.

     Option Term.  Each  outstanding  option held by an individual  serving as a
Board member on January 1, 1997 and each  subsequently  granted option under the
Director Plan will remain outstanding for a period of 10 years measured from the
automatic  grant date,  whether or not the  optionee  continues  to serve on the
Board.  Such  options  will,  however,  be  subject to  earlier  termination  in
connection with certain changes in control or ownership of the Company. Prior to
the  amendments  to the  Directors  Plan  which  form  part  of  this  Proposal,
outstanding options would not remain exercisable for more than a 12-month period
following the optionee's cessation of Board service.

     Limitations.  No optionee is to have any stockholder rights with respect to
the option  shares  until the  optionee  has  exercised  the option and paid the
exercise price for the purchased shares. Options are generally not assignable or
transferable  other  than by will or the laws of  inheritance,  and  during  the
optionee's  lifetime the option may be exercised only by the optionee.  However,
the optionee may, in connection with his or her estate plan, transfer the option
during his or her  lifetime  to members of his or her  immediate  family or to a
trust established for such family members.

     Exercisability. Each initial option grant for 40,000 shares of Common Stock
will become  exercisable for such shares in a series of three  successive  equal
annual  installments  over the optionee's  period of continued  Board service as
follows:

     o   The first installment will become  exercisable on the first anniversary
         of   the   grant   date,   provided   optionee   attends   all  of  the
         regularly-scheduled  Board  meetings  held during the  one-year  period
         measured  from the grant  date.  The  second  installment  will  become
         exercisable  on the  second  anniversary  of the grant  date,  provided
         optionee  attends all of the  regularly-scheduled  Board  meetings held
         during the one-year period  measured from the first  anniversary of the
         grant date. The third installment will become  exercisable on the third
         anniversary  of the grant date,  provided  optionee  attends all of the
         regularly-scheduled  Board  meetings  held during the  one-year  period
         measured from the second anniversary of the grant date.

                                       17

<PAGE>

     o   Should the  optionee  not attend all of the  scheduled  Board  meetings
         during the applicable  one- year period,  then the option will lapse as
         to the number of shares  determined  by  multiplying  one-third  of the
         total option shares by a fraction, the numerator of which is the number
         of such  meetings  not attended by the  optionee  during that  one-year
         period  and the  denominator  of  which  is the  total  number  of such
         meetings held during that period.

     Each  annual  option  grant for 3,000  shares of Common  Stock will  become
exercisable in its entirety one year after the grant date, provided the optionee
attends all of the regularly-scheduled  Board meetings held during that one-year
period.  Should the optionee not attend all of the scheduled meetings,  then the
option  will  lapse as to the number of shares  determined  by  multiplying  the
number of total  option  shares by a  fraction,  the  numerator  of which is the
number of such meetings not attended by the optionee during that one-year period
and the  denominator  of which is the total number of such  meetings held during
such period.

     Each  special  option  grant for 40,000  shares of Common Stock will become
exercisable  for  the  option  shares  in  three  equal  installments  over  the
optionee's period of continued Board service as follows:

     o   The first installment will become exercisable upon the later of (i) the
         first anniversary of the grant date of the initial automatic option for
         40,000  shares  (the  "Initial  Grant  Date")  which  was  made to such
         optionee but the economic  benefit of which was assigned to the venture
         capital fund or other investment entity or corporate partner with which
         he or she was  affiliated  at that time or (ii) the  grant  date of the
         special   option,   provided   the   optionee   attended   all  of  the
         regularly-scheduled  Board  meetings  held during the  one-year  period
         measured  from the Initial  Grant  Date.  The second  installment  will
         become exercisable upon the later of (ii) the second anniversary of the
         Initial  Grant  Date or (ii)  the  grant  date of the  special  option,
         provided the optionee  attended  all of the  regularly-scheduled  Board
         meetings  held  during  the  one-year  period  measured  from the first
         anniversary  of the Initial  Grant  Date.  The final  installment  will
         become  exercisable upon the later of (i) the third  anniversary of the
         Initial  Grant  Date or (ii)  the  grant  date of the  special  option,
         provided the optionee  attended  all of the  regularly-scheduled  Board
         meetings  held  during the  one-year  period  measured  from the second
         anniversary of the Initial Grant Date.

     o   Should the  optionee  not attend all of the  scheduled  Board  meetings
         during the applicable one- year period, the option will lapse as to the
         number of  shares  determined  by  multiplying  one-third  of the total
         option  shares by a fraction,  the  numerator of which is the number of
         such meetings not attended by the optionee  during that one-year period
         and the  denominator of which is the total number of such meetings held
         during that period.

     Termination  of Board  Membership.  Should the optionee cease to serve as a
Board  member  for any reason  (other  than  death)  while  holding  one or more
automatic  option  grants,  then such optionee will have until the expiration of
the 10-year  option term in which to exercise each such option for any or all of
the shares of Common Stock for which that option is  exercisable  at the time of
his or her  cessation  of service on the Board.  Should the  optionee  die while
serving as a Board member,  then any  outstanding  automatic  grant held by such
optionee at the time of death may be subsequently  exercised,  for any or all of
the shares of Common Stock at the time  subject to that option,  by the personal
representative  of the optionee's estate or by the person or persons to whom the
option is transferred  pursuant to the optionee's will or in accordance with the
laws of inheritance.  The option will remain so exercisable until the expiration
of the 10-year  term.  All options under the Directors  Plan will,  however,  be
subject to earlier  termination in connection with certain changes in control or
ownership of the Company.

     Corporate  Transaction.  Upon  the  occurrence  of  any  of  the  following
transactions (a "Corporate Transaction"):

         (i) a merger or consolidation in which the Company is not the surviving
     entity,  except  for a  transaction  the  principal  purpose of which is to
     change the state of the Company's incorporation;

         (ii) the sale of all, or substantially  all, of the Company's assets in
     complete liquidation or dissolution of the Company; or

                                       18

<PAGE>

         (iii) any reverse merger in which the Company is the surviving  entity,
     but in which all of the Company's  outstanding  voting stock is transferred
     to the acquiring entity or its wholly-owned subsidiary;

         each automatic option grant not otherwise at the time fully exercisable
     will  accelerate  so that each such option will,  immediately  prior to the
     specified  effective  date  for the  Corporate  Transaction,  become  fully
     exercisable  with  respect to the total number of shares of Common Stock at
     the time subject to such option and may be exercised for all or any portion
     of such shares.  Immediately  following the  consummation of such Corporate
     Transaction,   all  outstanding  options  under  the  Directors  Plan  will
     terminate, except to the extent assumed by the successor corporation or its
     parent company.

     Change in Control.  In connection  with a change in control of the Company,
whether  effected by a successful  tender offer for securities  possessing  more
than  40% of the  total  combined  voting  power  of the  Company's  outstanding
securities  or through a change in the  majority of the Board as a result of one
or more contested  elections for Board  membership,  each outstanding  automatic
option  grant  will  accelerate  so that  each such  option  will  become  fully
exercisable  with  respect to the total  number of shares of Common Stock at the
time subject to such option and may be exercised  for all or any portion of such
shares at any time prior to the  expiration or sooner  termination of the option
term.

     Cash-Out of Options.  Upon the  successful  completion of a hostile  tender
offer for securities possessing more than 40% of the total combined voting power
of the Company's outstanding securities, each outstanding option grant under the
Directors Plan will  automatically  be cancelled,  whether or not that option is
otherwise  exercisable for any option shares,  in return for a cash distribution
from the Company in an amount per cancelled  option share equal to the excess of
(i) the highest  price per share of Common  Stock paid in such tender offer over
(ii) the option exercise price payable per share.  Stockholder  approval of this
Proposal will also constitute  pre-approval of such automatic  cancellation  and
cash-out of all options granted under the Directors Plan on or after the date of
the Annual Meeting.

     The  acceleration  of options in the event of a  Corporate  Transaction  or
other take-over event may be seen as an anti-takeover provision and may have the
effect of discouraging a merger proposal, a takeover attempt or other efforts to
gain control of the Company.

     Changes  in  Capitalization.  In the event any change is made to the Common
Stock  issuable  under the  Directors  Plan by reason of any stock split,  stock
dividend,  combination of shares,  exchange of shares or other change  affecting
the  outstanding  Common  Stock as a class  without  the  Company's  receipt  of
consideration,  appropriate  adjustments  will be made to (i) the maximum number
and/or class of securities  issuable under the Directors  Plan,  (ii) the number
and/or class of securities to be made the subject of each  subsequent  automatic
grant made to newly-elected or continuing  non-employee  Board members and (iii)
the number and/or class of securities  purchasable under each outstanding option
and the  exercise  price  payable per share in order to prevent the  dilution or
enlargement of benefits thereunder.

     Each  outstanding  option  that is assumed in  connection  with a Corporate
Transaction  will be  appropriately  adjusted to apply and pertain to the number
and class of securities which would have been issued to the option holder in the
consummation  of such  Corporate  Transaction  had that  option  been  exercised
immediately prior to such Corporate  Transaction.  Appropriate  adjustments will
also be made to the exercise price payable per share and to the class and number
of securities available for future issuance under the Directors Plan.

     Plan  Amendments.  The Board may amend the provisions of the Directors Plan
at any time, subject to any required  stockholder  approval under applicable law
or regulation.

     Plan Termination. Unless sooner terminated by the Board, the Directors Plan
will terminate on January 27, 2002. Any options  outstanding at the time of such
termination  will  remain  in force in  accordance  with the  provisions  of the
instruments evidencing such grants.

                                       19

<PAGE>

Option Grant Summary

     The table below provides,  as to each current non-employee Board member and
all  non-employee  Board  members as a group,  the  following  information  with
respect to the  automatic  stock  option  grants made under the  Directors  Plan
during the period  beginning  January 1, 1996 and  continuing  through March 31,
1997: (i) the number of shares for which such automatic  option grants have been
and (ii) the weighted average exercise price payable per share.

                                                                Weighted
                                                                 Average
                                                     Number      Exercise
                                                    of Option     Price
                  Name of Director                   Shares     Per Share
- -------------------------------------------------- ----------- -----------
J. Stephan Dolezalek ..............................   3,000      $26.00
Edward E. Luck ....................................   3,000      $26.00
John E. Lyons .....................................   3,000      $26.00
Richard D. Murdock ................................   3,000      $26.00
Julius L. Pericola ................................   3,000      $26.00
Alan E. Salzman ...................................   3,000      $26.00
All non-employee directors as a group (6 persons)    18,000      $26.00

New Plan Benefits

     As of March 31, 1997, no options have been granted under the Directors Plan
on the basis of the 250,000-share increase which forms part of this Proposal No.
3. If the  stockholders  approve the Proposal,  then the  following  outstanding
options held by the non-employee Board members will remain exercisable,  for any
shares for which those  options are  exercisable  at the time of the  optionee's
cessation of Board  service,  for the entire  10-year  option  term,  subject to
earlier  termination in the event of certain  changes in control or ownership of
the Company:  Mr. Dolezalek,  options for 46,000 shares with an average exercise
price of $14.03 per share;  Mr. Luck,  options for 11,716 shares with an average
exercise price of $14.34 per share; Mr. Lyons, options for 32,668 shares with an
average  exercise  price of $11.12 per share;  Mr.  Murdock,  options for 46,000
shares with an average exercise price of $14.09 per share; Mr. Pericola, options
for 32,668 shares with an average  exercise  price of $11.05 per share;  and Mr.
Salzman,  options for 48,716 shares with an average exercise price of $12.94 per
share.

Federal Income Tax Consequences

     Options  granted under the Directors Plan are  non-statutory  options which
are not  intended to satisfy  the  requirements  of Section 422 of the  Internal
Revenue Code. The Federal income tax treatment for the options is as follows:

     Recognition of Income.  No taxable income is recognized by an optionee upon
the grant of a  non-statutory  option.  The optionee  will,  however,  recognize
ordinary  income,  in the year in which the  option is  exercised,  equal to the
excess of the fair market value of the  purchased  shares on the  exercise  date
over the exercise price paid for the shares.

     Income Tax  Deduction.  The Company will be entitled to a business  expense
deduction, for the taxable year of the Company in which the option is exercised,
equal to the amount of ordinary income  recognized by the optionee in connection
with such exercise.

Recommendation of the Board of Directors

     The affirmative vote of a majority of the outstanding  voting shares of the
Company  present  or  represented  by Proxy and  entitled  to vote at the Annual
Meeting is required for approval of the amendments to the Directors Plan. Should
such stockholder approval not be obtained,  then any stock options granted under
the Directors Plan on the basis of the  250,000-share  increase which forms part
of this Proposal will terminate without ever becoming exercisable for any of the
shares of Common Stock subject to those options,  and no further options will be
granted on the basis of that increase. In addition, all

                                       20

<PAGE>

currently  outstanding and subsequently granted options under the Directors Plan
would  remain  subject  to a maximum  12-month  exercise  period  following  the
optionee's  cessation  of  Board  service,  and  certain  other  changes  to the
Directors  Plan  (including the  stockholder  approval  requirements)  that were
intended  to take  advantage  of the  recent  amendments  to Rule  16b-3  of the
Exchange Act will not be implemented.  The Directors Plan will, however,  remain
in existence in  accordance  with the  provisions of the plan document in effect
immediately  prior to the new amendments,  and stock options will continue to be
made under the  Directors  Plan until the share  reserve as last approved by the
stockholders is issued.

     The Board recommends that the stockholders vote IN FAVOR OF the approval of
all amendments to the Directors Plan.

                   PROPOSAL FOUR--RATIFICATION OF SELECTION OF
                             INDEPENDENT ACCOUNTANTS

     The  Board  has  appointed  the  firm of  Ernst &  Young  LLP,  independent
accountants,  to audit the  financial  statements  of the Company for the fiscal
year ending  December 31, 1997,  and is asking the  stockholders  to ratify this
appointment.

     In the event the  stockholders  fail to ratify the  appointment,  the Board
will reconsider its selection.  Even if the selection is ratified,  the Board in
its discretion may direct the appointment of a different independent  accounting
firm at any time during the year if the Board feels that such a change  would be
in the best interest of the Company and its  stockholders.  The affirmative vote
of  the  holders  of a  majority  of  the  Company's  Common  Stock  present  or
represented  by Proxy at the Annual  Meeting and entitled to vote is required to
ratify the selection of Ernst & Young LLP.

     Ernst & Young LLP served as  independent  auditors  to the  Company for the
fiscal year ended  December 31, 1996. A  representative  of Ernst & Young LLP is
expected  to be  present  at  the  Annual  Meeting  to  respond  to  appropriate
questions, and will be given the opportunity to make a statement if he or she so
desires.

     The  Board  recommends  that  the   Stockholders   vote  IN  FAVOR  OF  the
ratification  of the  selection  of Ernst & Young LLP to serve as the  Company's
independent accountants for the fiscal year ending December 31, 1997.

                                       21

<PAGE>

                  EXECUTIVE COMPENSATION AND OTHER INFORMATION

Compensation Committee Report on Executive Compensation

     It is the duty of the  Compensation  Committee to review and  determine the
salaries and bonuses of executive  officers of the Company,  including the Chief
Executive Officer, and to establish the general  compensation  policies for such
individuals.  The  Compensation  Committee  also  has  the  sole  and  exclusive
authority  to  make  discretionary  option  grants  to the  Company's  executive
officers under the Company's Stock Option Plan.

     The Compensation  Committee believes that the compensation programs for the
Company's  executive  officers should reflect the Company's  performance and the
value  created for the Company's  stockholders.  In addition,  the  compensation
programs should support the short-term and long-term  strategic goals and values
of the  Company  and should  reward  individual  contribution  to the  Company's
success.  The  Company  is  engaged  in a very  competitive  industry,  and  the
Company's  success  depends  upon its  ability to attract  and retain  qualified
executives  through  the  competitive  compensation  packages  it offers to such
individuals.

     General  Compensation  Policy.  The Compensation  Committee's  policy is to
provide the Company's  executive officers with compensation  opportunities which
are tied to their personal performance, the financial performance of the Company
and their  contribution to that performance and which are competitive  enough to
attract  and  retain  highly  skilled  individuals.   Each  executive  officer's
compensation  package is  comprised of three  elements:  (i) base salary that is
competitive  with the market and reflects  individual  performance,  (ii) annual
variable   performance  awards  payable  in  cash  and  tied  to  the  Company's
achievement  of  annual   financial   performance   goals  and  (iii)  long-term
stock-based  incentive  awards designed to strengthen the mutuality of interests
between the executive officers and the Com- pany's stockholders. As an officer's
level of  responsibility  increases,  a greater  proportion  of his or her total
compensation  will be dependent  upon the Company's  financial  performance  and
stock price appreciation rather than base salary.

     The  Compensation  Committee  has retained  the services of an  independent
compensation  consulting  firm  to  provide  advice  on  executive  compensation
matters,  including the base salary levels for executive officers other than the
Chief Executive Officer and the incentive  compensation payable to all executive
officers.  Specifically,  the  consulting  firm  furnished  the  Committee  with
compensation  surveys and data for purposes of comparing the Company's executive
compensation levels with those at companies within and outside the industry with
which the Company  competes for executive talent and provided the Committee with
specific recommendations for maintaining the Company's executive compensation at
a level competitive with the marketplace.

     Factors. The principal factors that were taken into account in establishing
each  executive  officer's  compensation  package  for the 1996  fiscal year are
described below. However, the Compensation Committee may in its discretion apply
entirely different factors, such as different measures of financial performance,
for future fiscal years.

     Base  Salary--Chief  Executive  Officer.  In setting the base salary  level
payable for the 1996 fiscal year to the Company's Chief Executive Officer, Craig
R. McMullen,  the Committee reviewed a detailed performance  evaluation compiled
for Mr.  McMullen.  The  performance  evaluation  took  into  consideration  Mr.
McMullen's  qualifications,  the level of experience brought to his position and
gained  while in the  position,  the Company  goals for which Mr.  McMullen  had
responsibility,  specific  accomplishments  to date,  and the  importance of Mr.
McMullen's individual  contributions to the achievement of the Company goals and
objectives  set for  the  prior  fiscal  year.  In  addition,  the  Compensation
Committee  sought to provide him with a level of base salary  which it believed,
on the basis of its understanding of the salary levels in effect for other chief
executive officers at similar-sized companies in the industry, to be competitive
with those base salary levels.

     Base  Salary--Other  Executive  Officers.  In  setting  base  salaries  for
executive  officers other than the Chief  Executive  Officer,  the  Compensation
Committee reviewed the compensation data and surveys provided by the independent
consultant for comparative compensation purposes. A peer group of 25

                                       22

<PAGE>

companies was identified for such  comparative  purposes.  In selecting the peer
group companies,  the Compensation  Committee focused primarily on whether those
companies  were  actually  competitive  with the  Company in  seeking  executive
talent,  whether those  companies had a management  style and corporate  culture
similar to the  Company's and whether  similar  positions  existed  within their
corporate  structure.  A  majority  of the peer  group  companies  surveyed  for
comparative   compensation   purposes   were  also   included   in  the   Nasdaq
Pharmaceutical  Index  which the Company  has chosen as the  industry  index for
purposes of the Company Stock Price Performance graph which follows this report.

     The base  salary  for each  executive  officer  other the  Chief  Executive
Officer  reflects the salary levels for  comparable  positions at the peer group
companies  as  well  as  the  individual's  personal  performance  and  internal
alignment  considerations.  The relative weight given to each factor varies with
each  individual in the sole  discretion  of the  Compensation  Committee.  Each
executive  officer's  base salary is adjusted  each year on the basis of (i) the
Compensation  Committee's  evaluation of the officer's personal  performance for
the  year and  (ii)  the  competitive  marketplace  for  persons  in  comparable
positions.  For the 1996 fiscal year, the base salary of the Company's executive
officers was targeted at the 50th percentile of the base salary levels in effect
for  comparable  positions at the peer group  companies,  subject to 20% variant
above or below that level for certain officers of the Company.

     Annual Incentive  Compensation.  For the 1996 fiscal year, the Compensation
Committee  established,  with the  assistance  of the  independent  compensation
consultant,  an incentive compensation program for the executive officers. Since
the Company is in the  development  stage,  the use of  traditional  performance
milestones  (such as profit  levels  and return on equity) as the basis for such
incentive  compensation was not considered  appropriate.  Instead, the incentive
awards for the 1996  fiscal  year were tied to the  achievement  of  pre-defined
personal and corporate  performance targets.  The corporate  performance targets
for such  fiscal  year  were tied to  appreciation  in the  market  price of the
Company's common stock and approval of the Company's  manufacturing  facility by
the Food and Drug  Administration  (the  "FDA").  On the basis of the  Company's
success  in  achieving  the FDA  milestone  and the  Committee's  evaluation  of
personal  performance for the year, the executive officers (other than the Chief
Executive  Officer)  received  bonuses which ranged from 14.2% to 22.1% of their
base salary for the year.

     Long Term Incentives.  Generally, stock option grants are made periodically
by the Compensation Committee to each of the Company's executive officers.  Each
grant is designed to align the interests of the executive  officer with those of
the  stockholders  and provide each individual  with a significant  incentive to
manage the Company from the  perspective of an owner with an equity stake in the
business.  Each grant  allows the  officer  to acquire  shares of the  Company's
Common  Stock at a fixed price per share (not less than 85% of the market  price
of the  shares  on the grant  date)  over a  specified  period of time (up to 10
years).  Each option  becomes  exercisable  in a series of  installments  over a
four-year period,  contingent upon the officer's  continued  employment with the
Company.  Accordingly,  the  option  will  provide  a  meaningful  return to the
executive  officer only if he or she remains  employed by the Company during the
vesting period, and then only if the market price of the shares appreciates over
the option term.

     The size of the option grant to each executive officer, including the Chief
Executive  Officer,  is set by the  Compensation  Committee  at a level  that is
intended to create a meaningful  opportunity  for stock ownership based upon the
individual's  current  position  with the  Company,  the  individual's  personal
performance in recent periods and his or her potential for future responsibility
and promotion  over the option term. In  determining  the  appropriate  level of
equity incentive to be provided each individual, the Compensation Committee also
takes into account the number of unvested options held by the executive  officer
and the comparable level of equity-based  awards provided similar individuals in
the industry as reflected in comparative  industry data.  However,  the relevant
weight given to each of these factors  varied from  individual to individual for
the grants made during the 1996 fiscal year.

     CEO  Compensation.  As indicated  above,  the base salary for the Company's
Chief  Executive  Officer,  Craig  R.  McMullen,  for the 1996  fiscal  year was
established  by  the  Committee  on  the  basis  of a  detailed  review  of  his
performance and was increased to $300,000. On the basis of certain corporate and
individual  milestones  which the Committee had previously  established  for Mr.
McMullen  for the 1996  fiscal  year and  which  milestones  had been  met,  the
Committee determined that Mr. McMullen was

                                       23

<PAGE>

entitled to a bonus of $57,000 for the 1996 fiscal  year.  Because of the number
of stock  options  granted to Mr.  McMullen  through the 1995 fiscal  year,  the
Committee  decided not to grant any  additional  stock options to him during the
1996 fiscal year.

Compliance with Internal Revenue Code Section 162(m)

     Section  162(m) of the Internal  Revenue Code  disallows a tax deduction to
publicly held  companies  for  compensation  paid to certain of their  executive
officers, to the extent that compensation exceeds $1 million per covered officer
in any fiscal year. The  limitation  applies only to  compensation  which is not
considered to be  performance-based.  Non-performance based compensation paid to
the Company's  executive officers for the 1996 fiscal year did not exceed the $1
million limit per officer,  and the  Compensation  Committee does not anticipate
that  the  non-performance  based  compensation  to be  paid  to  the  Company's
executive  officers  for fiscal  1997 will  exceed  that  limit.  The  Company's
Restricted Stock Plan has been structured so that any  compensation  deemed paid
in  connection  with the exercise of option  grants made under that plan with an
exercise  price equal to the fair market value of the option shares on the grant
date will qualify as performance-based compensation which will not be subject to
the $1 million  limitation.  Because it is unlikely  that the cash  compensation
payable to any of the Company's  executive  officers in the  foreseeable  future
will approach the $1 millon  limit,  the  Compensation  Committee has decided at
this time not to take any action to limit or  restructure  the  elements of cash
compensation  payable to the  Company's  executive  officers.  The  Compensation
Committee will reconsider this decision should the individual cash  compensation
of any executive officer ever approach the $1 million level.

     The Board of Directors did not modify any action or recommendation  made by
the Compensation  Committee with respect to executive  compensation for the 1996
fiscal year. It is the opinion of the Compensation  Committee that the executive
compensation policies and plans provide the necessary total remuneration program
to properly align the Company's  performance  and the interests of the Company's
stockholders through the use of competitive and equitable executive compensation
in a balanced and reasonable manner, for both the short and long-term.

  Submitted by the Compensation Committee of the Company's Board of Directors:

                           Julius L. Pericola, Member
                             Alan E. Salzman, Member

Compensation Committee Interlocks and Insider Participation

     As of  December  31,  1996,  the  Compensation  Committee  of the Board was
comprised  of Messrs.  Pericola  and  Salzman.  No current or past member of the
Compensation Committee is a former or current officer or employee of the Company
or any of its subsidiaries.

     No  executive  officer of the Company  served on the board of  directors or
compensation  committee of any entity which has one or more  executive  officers
serving as a member of the Company's Board or Compensation Committee.

                                       24

<PAGE>

Performance Graph

     The graph  depicted  below  shows  the  Company's  stock  price as an index
assuming $100  invested on January 28, 1992 (the date of the  Company's  initial
public  offering)  at the then current  market price of $15.00 per share,  along
with the composite prices of companies listed in the Nasdaq Pharmaceutical Index
and Nasdaq Total U.S. Stock Market Index.  This information has been provided to
the Company by the Nasdaq Stock Market.

[The following  descriptive  data is supplied in accordance  with Rule 304(d) of
Regulation S-T]

     1/28/92         $100        $100        $100
     3/31/92           73          85          97
     6/30/92           40          71          91
     9/30/92           41          67          94
    12/31/92           58          81         110
     3/31/93           45          59         112
     6/30/93           60          62         114
     9/30/93           63          67         124
    12/31/93           70          73         126
     3/31/94           74          59         121
     6/30/94           68          52         115
     9/30/94           95          58         125
    12/31/94           92          55         123
     3/31/95           92          59         132
     6/30/95           90          69         154
     9/30/95           93          86         172
    12/31/95          125         100         174
     3/31/96          154         105         182
     6/30/96          120         101         197
     9/30/96           53         103         204
    12/31/96           41         100         214

   The indexes above assume the reinvestment of all dividends.

     Notwithstanding  anything to the contrary set forth in any of the Company's
previous filings under the Securities Act of 1933, as amended, or the Securities
Exchange Act of 1934, as amended, which might incorporate future filings made by
the Company under those statutes, the preceding Compensation Committee Report on
Executive  Compensation  and the  Company  Stock  Performance  Graph will not be
incorporated by reference into any of those prior filings,  nor will such report
or graph be  incorporated  by  reference  into any  future  filings  made by the
Company under those statutes.

                                       25

<PAGE>

<TABLE>
Summary of Cash and Certain Other Compensation

     The  following  table  sets forth the  compensation  earned,  for  services
rendered in all capacities to the Company and its subsidiaries,  for each of the
last three fiscal years by the Company's  Chief  Executive  Officer and the four
other  highest paid  executive  officers  whose salary and bonus for fiscal 1996
were in excess of $100,000.  No executive  officer who would have otherwise been
included  in such table on the basis of salary and bonus  earned for fiscal 1996
resigned or terminated employment during that fiscal year. The individuals named
in the table will be hereinafter referred to as the Named Officers.
<CAPTION>

                           SUMMARY COMPENSATION TABLE

                                                                        LONG-TERM
                                                                       COMPENSATION
                                           ANNUAL COMPENSATION            AWARDS
                                   ---------------------------------- --------------
                                                         OTHER ANNUAL    SECURITIES     ALL OTHER
                                     SALARY     BONUS    COMPENSATION    UNDERLYING    COMPENSATION
NAME AND PRINCIPAL POSITION  YEAR      ($)     ($)(1)        ($)        OPTIONS (#)        ($)
- --------------------------- ------ --------- --------- -------------- -------------- --------------
<S>                          <C>    <C>        <C>        <C>            <C>           <C>
Craig R. McMullen            1996   300,000    57,000     6,000 (2)         --          1,188 (3)
 President and Chief         1995   261,250   100,000     6,000 (2)      40,000           --
 Executive Officer           1994   215,000    60,000     6,000 (2)      40,000           --

James R. Glynn               1996   190,000    42,050       --           20,000         76,188 (4)
 Chief Operating Officer,    1995    82,500    18,000       --           90,000         15,000 (4)
 Chief Financial Officer     1994       --        --        --              --            --
 and Secretary

Andrew G. Korey, Ph.D.       1996   175,000    24,950       --           20,000           --
 Vice President, Medical     1995   164,625    31,800       --              --            --
 Information and             1994   158,500       --        --           30,000           --
 Extramural Scientific
 Affairs

Richard E. Jones, Ph.D.      1996   173,000    28,200       --           20,000         1,188 (3)
 Vice President,             1995   158,833    31,200       --              --            --
 Research and                1994   144,000       --        --           30,000           --
 Development

Dennis M. Brown, Ph.D.       1996   164,583    29,750       --           65,000         1,188 (3)
 Vice President,             1995   144,167    20,155       --              --            --
 Discovery Research          1994   135,526       --        --              --            --
- ----------
<FN>
(1)  Bonuses are reported for the year earned,  although  generally  paid in the
     subsequent year.
(2)  Represents yearly automobile allowance for Mr. McMullen.
(3)  Represents  compensation  associated with a matching contribution in shares
     of Common  Stock  which the  Company  made on the  officer's  behalf to the
     Company's 401(k) Plan (194 shares of Common Stock at $6.125 per share).
(4)  Represents  relocation  allowance  for Mr.  Glynn  of  $15,000  in 1995 and
     $75,000 in 1996. In 1996 the Company also made a matching  contribution  in
     shares of Common Stock on Mr. Glynn's  behalf to the Company's  401(k) Plan
     (194 shares of Common Stock at $6.125 per share).
</FN>
</TABLE>

                                       26

<PAGE>

<TABLE>
Stock options, Exercises and Holdings

     The following table provides  information  with respect to the stock option
grants made  during  fiscal 1996 to the Named  Officers.  No stock  appreciation
rights were granted during such fiscal year to the Named Officers.
<CAPTION>

                        OPTION GRANTS IN LAST FISCAL YEAR

                                                                                     POTENTIAL REALIZABLE
                                                                                           VALUE AT
                                                                                   ASSUMED ANNUAL RATES OF
                                                                                   STOCK PRICE APPRECIATION
                                                                                             FOR
                                 INDIVIDUAL GRANTS                                      OPTION TERM(3)
- --------------------------------------------------------------------------------- ------------------------
                             NUMBER OF
                            SECURITIES    PERCENT OF TOTAL
                            UNDERLYING    OPTIONS GRANTED
                          OPTIONS GRANTED TO EMPLOYEES IN   EXERCISE  EXPIRATION
           NAME               (#)(1)        FISCAL YEAR     PRICE(2)     DATE        5% ($)      10% ($)
- ------------------------ --------------- ---------------- ---------- ------------ ------------ -----------
<S>                          <C>              <C>           <C>        <C>         <C>          <C>       
James R. Glynn ..........    20,000           1.65          $6.375     09/26/06    $  207,684   $  330,702
Andrew G. Korey, PH.D. ..    20,000           1.65          $6.375     09/26/06    $  207,684   $  330,702
Richard E. Jones, PH.D...    20,000           1.65          $6.375     09/26/06    $  207,684   $  330,702
Dennis M. Brown, PH.D. ..    15,000           1.24          $6.375     09/26/06    $  155,763   $  248,027
                             50,000           4.12          $12.75     07/18/06    $1,038,420   $1,653,515
- ----------
<FN>
(1)  Each option will become  exercisable  for 25% of the option shares upon the
     optionee's  completion  of one year of service with the  Company,  measured
     from the grant  date,  and will become  exercisable  for the balance of the
     option shares in a series of 36 equal and successive  monthly  installments
     upon the optionee's  completion of each additional  month of service;  over
     the next 36 months  thereafter.  Each of the options (other than the second
     option  indicated  for Mr.  Brown) was granted on September  26, 1996.  The
     second option indicated for Mr. Brown was granted on July 18, 1996. None of
     the granted  options  will become  exercisable  for any  additional  shares
     following the optionee's cessation of service.  Each of the granted options
     will  immediately  become  exercisable  for all of the option shares in the
     event the Company is acquired by a merger or asset sale, unless the options
     are assumed by the acquiring  entity.  Each option has a maximum term of 10
     years,  subject  to  earlier  termination  in the  event of the  optionee's
     cessation of service with the Company.

(2)  The exercise  price may be paid in cash or in shares of Common  Stock.  The
     option may also be exercised through a cashless exercise procedure pursuant
     to which the shares  purchased under the option are  immediately  sold by a
     designated  brokerage  firm,  and a portion  of the sale  proceeds  is paid
     directly  to the  Company in payment of the option  exercise  price for the
     purchased  shares.  The Company may also allow the  optionee to finance the
     option  exercise by delivering a promissory note in payment of the exercise
     price for the  purchased  shares and any taxes  incurred by the optionee in
     connection with such exercise.

(3)  There is no assurance provided to any executive officer or any other holder
     of the Company's  securities that the actual stock price  appreciation over
     the 10-year option term will be at the assumed five percent and ten percent
     levels or at any other defined level. Unless the market price of the Common
     Stock  appreciates over the option term, no value will be realized from the
     option grants made to the executive officers.
</FN>
</TABLE>

                                       27

<PAGE>

<TABLE>
Option Holdings

     The table below sets forth  information  concerning the exercise of options
during fiscal 1996 by the Named Officers and unexercised  options held as of the
end of  such  year  by such  individuals.  No  stock  appreciation  rights  were
exercised  by  the  Named  Officers  during  such  fiscal  year,  and  no  stock
appreciation  rights  were held by such  individuals  at the end of such  fiscal
year.
<CAPTION>

                   AGGREGATED OPTION EXERCISES IN FISCAL 1996
                     AND 1996 FISCAL YEAR-END OPTION VALUES

                                                        NO. OF SECURITIES            VALUE OF UNEXERCISED
                                                     UNDERLYING UNEXERCISED          IN-THE-MONEY OPTIONS
                            SHARES                    OPTIONS AT FY-END (#)              AT FY-END(1)
                           ACQUIRED     VALUE    ----------------------------- -------------------------------
                              ON       REALIZED                                                 UNEXERCISABLE
           NAME            EXERCISE      (2)       EXERCISABLE   UNEXERCISABLE  EXERCISABLE ($)       ($)
- ------------------------ ---------- ------------ ------------- --------------- --------------- ---------------
<S>                        <C>       <C>            <C>            <C>            <C>                <C>  
Craig R. McMullen .......  100,000   $2,636,875     252,053        37,501         1,206,334          --
James R. Glynn ..........    --        --            31,874        78,126               --           --
Andrew G. Korey, Ph.D.  .    --        --            49,494        35,001           198,605          --
Richard E. Jones, Ph.D.      --        --            73,323        35,001           335,800          --
Dennis M. Brown, Ph.D.  .    --        --               --         65,000               --           --
- ----------
<FN>
(1)  Determined by  subtracting  the exercise price from the market price of the
     Common Stock on December 31, 1996 ($6.125).

(2)  Excess of the fair market value of the purchased  shares at the time of the
     option exercise over the exercise price paid for those shares.
</FN>
</TABLE>

Officer Loans

     In October 1995,  the Company loaned James R. Glynn,  the Company's  Senior
Vice President,  Chief Financial Officer and Secretary,  the principal amount of
$100,000 in connection with Mr. Glynn's purchase of his principal residence (the
"Property").  Such loan must be repaid no later than October 13, 2000,  does not
bear  interest  and is secured by a second  deed of trust on the  Property.  The
highest principal amount  outstanding  during the fiscal year ended December 31,
1996 was, and the current amount outstanding is, $100,000.

Employment Contracrs and Termination of Employment Arrangements

     None of the Company's  executive  officers have employment  agreements with
the  Company,  and  their  employment  may  be  terminated  at any  time  at the
discretion  of  the  Board  of   Directors.   The   Compensation   Committee  as
administrator  of the Company's 1988 Restricted  Stock Plan has the authority to
provide for the accelerated vesting of the shares of Common Stock subject to any
outstanding  options held by the Chief Executive Officer and the Company's other
executive  officers or any unvested  shares  actually held by those  individuals
under the 1988 Restricted  Stock Plan, in the event their  employment were to be
terminated (whether involuntarily or through a forced resignation) following (i)
an  acquisition  of the  Company  by  merger  or asset  sale or (ii) a change in
control of the Company effected through a successful  tender offer for more than
50% of the Company's  outstanding  voting  securities or through a change in the
majority of the Board as a result of one or more  contested  elections for Board
membership.

Certain Relationships and Related Transactions

     The Company's Restated  Certificate of Incorporation and Bylaws provide for
indemnification of directors,  officers and other agents of the Company. Each of
the current  directors,  and  certain  officers  and agents of the Company  have
entered into separate indemnification agreements with the Company.

     The  Company  retains  Brobeck,  Phleger &  Harrison  LLP as its  principal
outside legal counsel. J. Stephan Dolezalek, a director of the Company, has been
a partner of Brobeck, Phleger & Harrison LLP since 1989.

                                       28

<PAGE>

      COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT OF 1934

     Section 16(a) of the Securities Exchange Act of 1934, as amended,  requires
the Company's officers,  directors and beneficial owners of more than 10% of the
outstanding  Common  Stock to file initial  reports of ownership  and reports of
changes in ownership of such Common Stock with the United States  Securities and
Exchange  Commission  ("SEC").  Such  officers,  directors  and greater than 10%
stockholders  are required by SEC regulations to furnish the Company with copies
of all Section 16(a) forms they file.

     Based  solely on its review of the copies of such  forms  furnished  to the
Company and written  representations  that no other reports were  required,  the
Company  believes  that during the period from  January 1, 1996 to December  31,
1996,  all  officers,  directors and  beneficial  owners of more than 10% of the
outstanding Common Stock complied with all Section 16(a) requirements.

           STOCK OWNERSHIP OF MANAGEMENT AND CERTAIN BENEFICIAL OWNERS

     The  following  table sets forth certain  information  known to the Company
with respect to the beneficial  ownership of the Common Stock as of December 31,
1996 by (i) all persons who are beneficial owners of five percent or more of the
Company's Common Stock, (ii) each director and nominee for election to the Board
at the Annual  Meeting,  (iii) the Named  Officers in the  Summary  Compensation
Table above and (iv) all current  directors and  executive  officers as a group.
The number of shares beneficially owned by each director or executive officer is
determined  under  rules  of the  SEC  and the  information  is not  necessarily
indicative of beneficial ownership for any other purpose. Shares of Common Stock
subject  to  options  currently  exercisable  or  exercisable  within 60 days of
December 31, 1996 are deemed  outstanding  for computing  the  percentage of the
person  holding such options but are not deemed  outstanding  for  computing the
percentage  of any other  person.  Except as  otherwise  indicated,  the Company
believes that the beneficial owners of the Common Stock listed below, based upon
such  information  furnished by such  owners,  have sole  investment  power with
respect to such shares, subject to community property laws where applicable.

                                       29

<PAGE>
<TABLE>

                             PRINCIPAL STOCKHOLDERS
<CAPTION>

                                                                                       PERCENT OF
                                                                           NUMBER     TOTAL SHARES
                            NAME AND ADDRESS                              OF SHARES OUTSTANDING(1)(2)
- ----------------------------------------------------------------------- ----------- ---------------
<S>                                                                    <C>               <C> 
State of Wisconsin Investment Board ....................................2,065,000        9.7%
  Post Office Box 7842
  Madison, WI 53707
Edward E. Luck(3) ......................................................  846,975        4.0%
Dennis M. Brown(3) .....................................................  610,526        2.9%
Craig R. McMullen(3) ...................................................  255,357        1.2%
Alan E. Salzman(4) .....................................................  104,933         *
Julius L. Pericola(3) ..................................................   47,668         *
J. Stephan Dolezalek(5) ................................................   32,466         *
John E. Lyons(3) .......................................................   24,950         *
Andrew G. Korey, Ph.D.(3) ..............................................   71,773         *
Richard E. Jones(3) ....................................................   74,573         *
James R. Glynn(3) ......................................................   35,624         *
All current directors and executive officers as a group (14 persons)(6) 2,133,595        9.8%
- ----------
<FN>
     * Less than one percent.

(1)  Percentage of beneficial ownership is calculated assuming 21,257,856 shares
     of Common Stock were outstanding on December 31, 1996. Beneficial ownership
     is determined in accordance  with the rules of the  Securities and Exchange
     Commission and generally  includes voting or investment  power with respect
     to  securities.  Shares of Common  Stock  subject to  options  or  warrants
     currently exercisable or convertible,  or exercisable or convertible within
     60 days of December 31, 1996,  are deemed  outstanding  for  computing  the
     percentage of the person  holding such option or warrant but are not deemed
     outstanding  for  computing the  percentage of any other person.  Except as
     indicated  in the  footnotes  to this  table  and  pursuant  to  applicable
     community  property  laws,  the persons named in the table have sole voting
     and   investment   power  with  respect  to  all  shares  of  Common  Stock
     beneficially owned.
(2)  This table is based upon  information  supplied to the Company by executive
     officers, directors and principal stockholders. The address of each officer
     and director  identified in this table is that of the  Company's  executive
     offices,  34700 Campus Drive, Fremont, CA 94555. Unless otherwise indicated
     in the footnotes to this table and subject to applicable community property
     laws,  each of the  stockholders  named in this  table has sole  voting and
     investment power with respect to the shares shown as beneficially  owned by
     it or him.
(3)  The amounts shown include shares which may be acquired  currently or within
     60 days after December 31, 1996, through the exercise of stock options,  as
     follows:  Mr. Luck,  8,716 shares;  Dr.  Brown,  no shares;  Mr.  McMullen,
     255,357 shares; Mr. Pericola,  29,668 shares; Mr. Lyons, 24,950 shares; Dr.
     Korey,  50,744  shares;  Dr. Jones,  74,573  shares and Mr.  Glynn,  35,624
     shares.
(4)  Represents 45,716 shares subject to options  exercisable  within 60 days of
     December 31, 1996,  49,694  shares held  directly by Mr.  Salzman and 9,523
     shares held by a trust for the benefit of Mr. Salzman.
(5)  Represents 29,666 shares subject to options  exercisable  within 60 days of
     December  31, 1996 and 2,800  shares held  directly by Mr.  Dolezalek.  Mr.
     Dolezalek,  a director  of the  Company  since  October 6, 1994,  is also a
     Partner in the law firm of Brobeck,  Phleger & Harrison  LLP, the Company's
     legal counsel.
(6)  Includes  583,764 shares subject to options  exercisable  within 60 days of
     December 31, 1996.
</FN>
</TABLE>

     To the Company's  knowledge,  each beneficial owner of more than 10% of the
Company's  capital  stock filed all reports and reported all  transactions  on a
timely basis with the SEC, National Association of Securities Dealers,  Inc. and
the Company.

                                       30

<PAGE>

                  DEADLINE FOR RECEIPT OF STOCKHOLDER PROPOSALS

     Proposals of  stockholders of the Company that are intended to be presented
by such  stockholders  at the Company's  1998 Annual Meeting must be received by
the Company no later than December 31, 1997 so they may be included in the proxy
statement and form of proxy relating to that meeting.

                                  ANNUAL REPORT

     A copy of the  Annual  Report of the  Company  for the  fiscal  year  ended
December 31, 1996 (the "Annual  Report") and the Company's Annual Report on Form
10-K, as filed with the  Securities  and Exchange  Commission  (the "Form 10-K")
have been mailed  concurrently  with this Proxy  Statement  to all  stockholders
entitled  to notice of and to vote at the  Annual  Meeting.  Neither  the Annual
Report nor the Form 10-K is  incorporated  into this Proxy Statement and neither
is considered proxy soliciting material.

                                    FORM 10-K

     The Company  filed an Annual  Report on Form 10-K with the  Securities  and
Exchange  Commission.  A copy of this report is being  mailed with the Notice of
Annual Meeting and Proxy Statement.  Additional copies may be obtained,  without
charge, by writing to Investor  Relations,  Matrix  Pharmaceutical,  Inc., 34700
Campus Drive, Fremont, California 94555.

                                  OTHER MATTERS

     The  Company  knows  of  no  other  matters  that  will  be  presented  for
consideration  at the Annual Meeting.  If any other matters properly come before
the Annual  Meeting,  it is the  intention of the persons  named in the enclosed
form of Proxy to vote the  shares  they  represent  as the Board may  recommend.
Discretionary  authority  with  respect to such other  matters is granted by the
execution of the enclosed Proxy. 

                                         THE BOARD OF DIRECTORS


Dated: May 23, 1997

                                       31


<PAGE>


                                                                      APPENDIX A

                           MATRIX PHARMACEUTICAL, INC.

                           1988 RESTRICTED STOCK PLAN

                AS AMENDED AND RESTATED EFFECTIVE MARCH 19, 1997


<PAGE>



                                TABLE OF CONTENTS



                                                                        Page

ARTICLE I................................................................  1
         GENERAL.........................................................  1
                  1.       PURPOSE OF THE PLAN...........................  1
                  2.       STRUCTURE OF THE PLAN.........................  1
                  3.       ADMINISTRATION OF THE PLAN....................  2
                  4.       OPTION GRANTS AND SHARE ISSUANCES.............  2
                  5.       STOCK SUBJECT TO THE PLAN.....................  3

ARTICLE II...............................................................  5
         OPTION GRANT PROGRAM............................................  5
                  1.       TERMS AND CONDITIONS OF OPTIONS...............  5
                  2.       INCENTIVE OPTIONS.............................  9
                  3.       STOCK APPRECIATION RIGHTS..................... 10
                  4.       CORPORATE TRANSACTION......................... 11
                  5.       CANCELLATION AND NEW GRANT OF OPTIONS......... 12
                  6.       EXTENSION OF EXERCISE PERIOD.................. 12

ARTICLE III.............................................................. 14
         STOCK ISSUANCE PROGRAM.......................................... 14
                  1.       TERMS AND CONDITIONS OF STOCK ISSUANCES....... 14
                  2.       CORPORATE TRANSACTION......................... 16

ARTICLE IV............................................................... 17
         MISCELLANEOUS................................................... 17
                  1.       LOANS OR INSTALLMENT PAYMENTS ................ 17
                  2.       AMENDMENT OF THE PLAN AND AWARDS.............. 17
                  3.       EFFECTIVE DATE AND TERM OF PLAN............... 18
                  4.       USE OF PROCEEDS............................... 20
                  5.       WITHHOLDING................................... 20
                  6.       REGULATORY APPROVALS.......................... 20
                  7.       NO EMPLOYMENT/SERVICE RIGHTS ................. 21

SPECIAL ADDENDUM.........................................................A-1


<PAGE>

                           MATRIX PHARMACEUTICAL, INC.
                           1988 RESTRICTED STOCK PLAN

                (As Amended and Restated Through March 19, 1997)


                                    ARTICLE I


         GENERAL

         1.       PURPOSE OF THE PLAN

                  (a) This 1988  Restricted  Stock Plan (the "Plan") is intended
to promote the interests of Matrix Pharmaceutical,  Inc., a Delaware corporation
(the "Corporation"),  by providing incentives to eligible individuals to acquire
a proprietary interest, or otherwise increase their proprietary interest, in the
Corporation  and to remain in the employ or service of the  Corporation  (or its
parent or subsidiary corporations).

                  (b) For purposes of the Plan, the following  provisions  shall
be applicable  in  determining  the parent and  subsidiary  corporations  of the
Corporation:

                           (i) Any corporation  (other than the  Corporation) in
         an unbroken chain of corporations  ending with the Corporation shall be
         considered to be a parent corporation of the Corporation, provided each
         such  corporation  in the unbroken  chain (other than the  Corporation)
         owns, at the time of the determination,  stock possessing fifty percent
         (50%) or more of the total  combined  voting  power of all  classes  of
         stock in one of the other corporations in such chain.

                           (ii) Each corporation (other than the Corporation) in
         an unbroken chain of corporations  beginning with the Corporation shall
         be considered to be a subsidiary of the Corporation, provided each such
         corporation  (other than the last  corporation)  in the unbroken  chain
         owns, at the time of the determination,  stock possessing fifty percent
         (50%) or more of the total  combined  voting  power of all  classes  of
         stock in one of the other corporations in such chain.

         2.       STRUCTURE OF THE PLAN

                  The Plan shall be divided  into two separate  components:  the
Option  Grant  Program  specified in Article II and the Stock  Issuance  Program
specified in Article III. Under the Option Grant Program,  eligible  individuals
may be granted options to purchase


<PAGE>

shares of the Corporation's  Common Stock at a discount of up to 15% of the fair
market value of such shares on the grant date.

                  The Stock Issuance Program will allow eligible  individuals to
purchase  shares of the  Corporation's  Common Stock at discounts  from the fair
market  value  of such  shares  of up to  15%.  Such  shares  may be  issued  as
fully-vested  shares or as shares to vest over time.  Issuances  may be effected
either  through direct  purchases or through the exercise of intervening  option
grants.

                  Unless the context clearly indicates otherwise, the provisions
of  Articles I and IV of the Plan shall apply to both the Option  Grant  Program
and the Stock Issuance Program and shall accordingly govern the interests of all
individuals in the Plan.

         3.       ADMINISTRATION OF THE PLAN

                  (a)  The  Plan   shall   be   administered   by  a   committee
("Committee") of two (2) or more members of the Corporation's Board of Directors
appointed by the Board.  Members of the Committee shall serve for such period of
time as the Board may  determine and shall be subject to removal by the Board at
any time.

                  (b) The Committee as Plan Administrator  shall have full power
and authority  (subject to the express provisions of the Plan) to establish such
rules and regulations as it may deem  appropriate for the proper  administration
of the Plan and to make such  determinations  under the Plan and any outstanding
option  grants  or  share  issuances  as it may  deem  necessary  or  advisable.
Decisions  of the Plan  Administrator  shall be final and binding on all parties
with an interest in the Plan.

                  (c) Service on the  Committee  shall  constitute  service as a
Board member, and members of the Committee shall accordingly be entitled to full
indemnification  and  reimbursement  as Board  members for their  service on the
Committee.  No member of the  Committee  shall be liable for any act or omission
made in good faith with  respect  to the Plan or any  option  granted  under the
Plan.

         4.       OPTION GRANTS AND SHARE ISSUANCES

                  (a) The persons  eligible to receive share issuances under the
Stock  Issuance  Program  ("Participant")  and/or option grants  pursuant to the
Option Grant Program ("Optionee") are as follows:

                           (i)  key  employees   (including   officers)  of  the
         Corporation  (or its  parent or  subsidiary  corporations)  who  render
         services which  contribute to the success and growth of the Corporation
         (or its parent or subsidiary  corporations)  or which may reasonably be
         anticipated to

                                       2.
<PAGE>

         contribute to the future success and growth of the  Corporation (or its
         parent or subsidiary corporations);

                           (ii)  non-employee  members of the Board or the board
         of directors of any parent or subsidiary corporation); and

                           (iii) those  consultants or  independent  contractors
         who  provide  valuable  services to the  Corporation  (or its parent or
         subsidiary corporations).

                  (b)  Non-employee  members of the Board shall also be eligible
to  receive   automatic   option  grants  pursuant  to  the  provisions  of  the
Corporation's 1991 Director Stock Option Plan.

                  (c) The  Plan  Administrator  shall  have  full  authority  to
determine, (I) with respect to the option grants made under the Plan, the number
of shares to be covered by each grant,  the time or times at which each  granted
option is to become  exercisable,  the option  price,  and the maximum  term for
which the option may remain outstanding and (II) with respect to share issuances
under  the Stock  Issuance  Program,  the  number of shares to be issued to each
Participant,  the  vesting  schedule  (if any) to be  applicable  to the  issued
shares, and the purchase price to be paid by the individual for such shares.

                  (d) The Plan Administrator  shall have the absolute discretion
to grant  options in  accordance  with  Article II of the Plan  and/or to effect
share issuances in accordance with Article III of the Plan.

         5.       STOCK SUBJECT TO THE PLAN

                  (a) The stock  issuable  under the Plan shall be shares of the
Corporation's  authorized  but  unissued or  reacquired  common  stock  ("Common
Stock").  The maximum number of shares  issuable over the term of the Plan shall
not exceed 4,869,048 shares*, subject to adjustment as provided in Section 5(c).
Should an  outstanding  option under the Plan expire or terminate for any reason
prior to exercise in full,  the shares  subject to the portion of the option not
so exercised will be available for subsequent  option grants and share issuances
under the Plan. Any unvested shares issued under the Plan and

- --------
*/Adjusted to reflect (i) the 2.1-for-1  reverse stock split of the  outstanding
Common  Stock  effected  in  January  1992,  (ii)  the  850,000-share   increase
authorized  for  issuance  under the Plan  approved by the Board on December 14,
1995 and approved by the  stockholders  at the 1996 Annual  Meeting and (iii) an
additional share increase of 2,000,000  shares  authorized by the Board on March
19, 1997, subject to stockholder  approval at the 1997 Annual Meeting.  From and
after March 31,  1997,  not more than  4,119,840  shares may be issued under the
Plan.

                                       3.

<PAGE>

subsequently  repurchased by the  Corporation,  at the option exercise or direct
issue price paid per share,  pursuant  to the  Corporation's  repurchase  rights
under the Plan  shall be added  back to the  number  of  shares of Common  Stock
reserved  for issuance  under the Plan and shall  accordingly  be available  for
reissuance  through  one or  more  subsequent  option  grants  or  direct  stock
issuances under the Plan. However,  the shares subject to any option (or portion
of an option)  surrendered or cancelled in accordance  with Section 3 of Article
II of the Plan shall not be  available  for  subsequent  option  grants or share
issuances under the Plan.

                  (b) In no event may any one  individual  participating  in the
Plan be granted stock options,  separately exercisable stock appreciation rights
and direct stock  issuances for more than 750,000  shares of Common Stock in the
aggregate over the remaining term of the Plan,  subject to adjustment  from time
to time in  accordance  with  paragraph  5(c) of this Article I. For purposes of
such limitation,  no stock options,  stock  appreciation  rights or direct stock
issuances granted prior to January 1, 1994 shall be taken into account.

                  (c) If any change is made to the Common Stock  issuable  under
the Plan by reason of any stock  dividend,  stock split,  combination of shares,
recapitalization,  or other change  affecting the outstanding  Common Stock as a
class  without the  Corporation's  receipt of  consideration,  then  appropriate
adjustments will be made to (i) the number and/or class of shares issuable under
the  Plan,  (ii) the  maximum  number  and/or  class of shares  for which  stock
options,  separately  exercisable  stock  appreciation  rights and direct  stock
issuances may be granted to any one  participant in the aggregate after December
31, 1993,  and (iii) the number  and/or class of shares and the option price per
share in effect under each  outstanding  option in order to prevent the dilution
or  enlargement  of rights and  benefits  under such  options.  The  adjustments
determined by the Plan Administrator will be final, binding and conclusive.

                  (d) Common Stock  issuable  under the Plan,  whether under the
Option  Grant  Program  or the Stock  Issuance  Program,  may be subject to such
restrictions  on  transfer,  repurchase  rights  or  other  restrictions  as are
determined by the Plan Administrator.



                                       4.
<PAGE>

                                   ARTICLE II

                              OPTION GRANT PROGRAM

         1.       TERMS AND CONDITIONS OF OPTIONS

                  Options  granted  pursuant to the Plan shall be  authorized by
action  of  the  Plan  Administrator  and  may,  at  the  Plan   Administrator's
discretion,  be either incentive stock options  qualified under Internal Revenue
Code Section 422 ("Incentive Options") or non-statutory options  ("Non-Statutory
Options")  which do not so qualify.  Individuals  who are not  employees  of the
Corporation  or its  parent  or  subsidiary  corporations  may  only be  granted
non-statutory  options.  Each  granted  option shall be evidenced by one or more
instruments in the form approved by the Plan Administrator;  provided,  however,
that each such instrument  shall comply with the terms and conditions  specified
below.  Each instrument  evidencing an Incentive  Option shall, in addition,  be
subject to the applicable provisions of Section 2 of this Article II.

                  (a)      Option Price.

                           (1) The option  price per share shall be fixed by the
Plan  Administrator,  but in no event  shall the option  price per share be less
than  eighty-five  percent  (85%) of the fair market  value of a share of Common
Stock on the date of the option grant.

                           (2) The option price will become immediately due upon
exercise of the option and,  subject to the  provisions of Article IV, Section 1
and the instrument evidencing the grant, will be payable in one of the following
alternative forms:

                                    (A) full payment in cash or check payable to
                  the Corporation; or

                                    (B) full  payment in shares of Common  Stock
                  held by the Optionee  for the  requisite  period  necessary to
                  avoid a charge to the  Corporation's  earnings  for  financial
                  reporting  purposes  and  valued at fair  market  value on the
                  Exercise Date (as such term is defined below); or

                                    (C) full payment in a combination  of shares
                  of Common Stock held by the Optionee for the requisite  period
                  necessary to avoid a charge to the Corporation's  earnings for
                  financial  reporting  purposes and valued at fair market value
                  on  the  Exercise  Date  and  cash  or  check  payable  to the
                  Corporation; or


                                       5.
<PAGE>

                                    (D) full  payment  through  a  broker-dealer
                  sale and remittance  procedure  pursuant to which the Optionee
                  (I) shall  provide  irrevocable  instructions  to a designated
                  brokerage  firm to effect the immediate  sale of the purchased
                  shares and remit to the Corporation,  out of the sale proceeds
                  available on the settlement  date,  sufficient  funds to cover
                  the aggregate  option price  payable for the purchased  shares
                  plus all  applicable  Federal and State income and  employment
                  taxes required to be withheld by the Corporation in connection
                  with such  purchase and (II) shall  provide  directives to the
                  Corporation  to deliver  the  certificates  for the  purchased
                  shares  directly to such  brokerage  firm in order to complete
                  the sale transaction.

                  For purposes of this  subsection  (a)(2),  the  Exercise  Date
shall be the date on which written notice of the option exercise is delivered to
the  Corporation.  Except to the extent  the sale and  remittance  procedure  is
utilized in  connection  with the exercise of the option,  payment of the option
price for the purchased shares must accompany such notice.

                           (3) For purposes of subsection (1) above (and for all
other  valuation  purposes under the Plan),  the fair market value of a share of
Common  Stock  on any  relevant  date  under  the  Plan  will be  determined  in
accordance with the following provisions:

                                    (A) If the  Common  Stock is not at the time
                  listed or  admitted  to trading on any stock  exchange  but is
                  traded on the Nasdaq National  Market System,  the fair market
                  value will be the closing selling price of one share of Common
                  Stock on the date in  question,  as such price is  reported by
                  the National  Association  of Securities  Dealers  through the
                  Nasdaq  National  Market  System or any successor  system.  If
                  there is no  reported  closing  selling  price for the  Common
                  Stock on the date in question,  then the closing selling price
                  on the last  preceding  date for which such  quotation  exists
                  shall be determinative of fair market value.

                                    (B)  If the  Common  Stock  is at  the  time
                  listed or admitted to trading on any stock exchange,  then the
                  fair  market  value will be the closing  selling  price of one
                  share of  Common  Stock on the date in  question  on the stock
                  exchange  determined  by  the  Plan  Administrator  to be  the
                  primary  market  for  the  Common  Stock,  as  such  price  is
                  officially  quoted on such  exchange.  If there is no reported
                  sale of Common Stock on such exchange on the date in question,
                  then the fair market value will be the closing  selling  price
                  on the  exchange  on the last  preceding  date for which  such
                  quotation exists.

                  (b) Term and Exercise of Options.  Each option  granted  under
the Plan will be  exercisable at such time or times and during such period as is
determined by the Plan Administrator and set forth in the stock option agreement
evidencing such grant.

                                       6.
<PAGE>

However,  no option  granted  under  this Plan will have a term in excess of ten
(10) years measured from the grant date.

                  (c) Limited Transferability of Options. During the lifetime of
the Optionee,  Incentive  Options shall be exercisable  only by the Optionee and
shall not be  assignable  or  transferable  other than by will or by the laws of
descent and distribution following the Optionee's death. However,  Non-Statutory
Options may, in connection with the Optionee's estate plan, be assigned in whole
or in  part  during  the  Optionee's  lifetime  to one or  more  members  of the
Optionee's  immediate  family or to a trust  established  exclusively for one or
more such family  members.  The  assigned  portion may only be  exercised by the
person or persons who acquire a proprietary  interest in the option  pursuant to
the assignment.  The terms  applicable to the assigned portion shall be the same
as those in effect for the option immediately prior to such assignment and shall
be set forth in such documents issued to the assignee as the Plan  Administrator
may deem appropriate.

                  (d)      Effect of Termination of Service.

                                    (1)  Should an  Optionee  cease to remain in
         Service for any reason  (including  death or  permanent  disability  as
         defined in Section  22(e)(3) of the  Internal  Revenue  Code) while the
         holder of one or more  outstanding  options  under the Plan,  then such
         option or options shall in no event remain  exercisable for more than a
         twelve (12) month period (or such shorter  period as is  determined  by
         the Plan Administrator and set forth in the option agreement) following
         the date of such cessation of Service (and under no circumstances shall
         any such option be exercisable  after the specified  expiration date of
         the option term). Each such option shall, during such twelve (12) month
         or shorter period,  be exercisable  only to the extent of the number of
         shares (if any) for which the option is exercisable on the date of such
         cessation of Service.  Upon the expiration of such twelve (12) month or
         shorter  period or (if earlier) upon the expiration of the option term,
         the option shall terminate and cease to be exercisable.

                                    (2) Any option  granted to an Optionee under
         the  Plan  and  exercisable  in  whole  or in part  on the  date of the
         Optionee's death may be subsequently exercised,  but only to the extent
         of the number of shares (if any) for which the option is exercisable on
         the date of the  Optionee's  cessation  of  Service  (less  any  shares
         subsequently  purchased by the Optionee  thereunder prior to death), by
         the personal  representative  of the Optionee's estate or by the person
         or persons to whom the option is transferred pursuant to the Optionee's
         will or in  accordance  with  the  laws of  descent  and  distribution,
         provided and only if such  exercise  occurs prior to the earlier of (i)
         the first  anniversary of the date of the Optionee's  death or (ii) the
         specified  expiration  date of the option term.  Upon the occurrence of
         the  earlier  event,  the  option  shall  terminate  and  cease  to  be
         exercisable.

                                       7.
<PAGE>

                                    (3)  The  Plan   Administrator   shall  have
         complete  discretion,  exercisable  either  at the time the  option  is
         granted or at any time the option remains outstanding, to permit one or
         more options granted under this Article II to be exercised,  during the
         applicable  exercise period under  subparagraph  (1) or (2) above,  not
         only for the number of shares for which each such option is exercisable
         at the time of the optionee's  cessation of Service but also for one or
         more subsequent installments of purchasable shares for which the option
         would  otherwise have become  exercisable had such cessation of Service
         not occurred.

                                    (4) For purposes of the foregoing provisions
         of this Section 1(c), an Optionee  shall be deemed to remain in Service
         for so long as such individual  renders  services to the Corporation or
         any  parent  or  subsidiary  corporation  on a  periodic  basis  in the
         capacity of an Employee,  a non-employee Board member or an independent
         consultant or advisor.  The Optionee  shall be deemed to be an Employee
         of the Corporation for so long as the Optionee remains in the employ of
         the   Corporation   or  one  or  more  of  its  parent  or   subsidiary
         corporations,  subject to the control  and  direction  of the  employer
         entity  not  only as to the  work to be  performed  but  also as to the
         manner and method of performance.

                  (e)  Stockholder  Rights.  An Optionee  shall have none of the
rights of a stockholder  with respect to any shares  covered by the option until
such Optionee has exercised the option,  paid the option price for the purchased
shares and been issued a stock certificate for the purchased shares.

                  (f)  Repurchase  Rights.  The shares of Common Stock  acquired
upon the  exercise  of options  granted  under the Plan may be subject to one or
more  repurchase  rights of the  Corporation  in  accordance  with the following
provisions:

                                    (1)  The  Plan   Administrator  may  in  its
         discretion subject one or more shares of Common Stock issued under this
         Article II to repurchase by the Corporation.  Any such repurchase right
         shall be exercisable by the  Corporation,  at the option price paid per
         share,  for any or all  unvested  shares  of Common  Stock  held by the
         Optionee  under this Article II at the time of his or her  cessation of
         Service.  The specific terms and conditions  upon which such repurchase
         right  shall  be so  exercisable  by  the  Corporation,  including  the
         establishment  of the appropriate  vesting schedule and other provision
         for the expiration of such right in one or more  installments  over the
         optionee's  period  of  Service,   shall  be  determined  by  the  Plan
         Administrator and set forth in the instrument evidencing such right.

                                    (2)  All  of the  Corporation's  outstanding
         repurchase rights shall automatically terminate, and all shares subject
         to such terminated

                                       8.
<PAGE>

         rights  shall  immediately  vest in full,  upon the  occurrence  of any
         Corporate Transaction under Section 4 of this Article II, except to the
         extent:  (i) any such  repurchase  right  is, in  connection  with such
         Corporate Transaction,  to be assigned to the successor corporation (or
         parent  thereof)  or  (ii)  such  termination  is  precluded  by  other
         limitations   imposed  by  the  Plan  Administrator  at  the  time  the
         repurchase right is granted.

                                    (3) The Plan  Administrator  shall  have the
         discretionary  authority,   exercisable  either  before  or  after  the
         optionee's  cessation of Service,  to cancel the Company's  outstanding
         repurchase  rights  with  respect to one or more  shares  purchased  or
         purchasable   by  the  optionee  under  this  Article  II  and  thereby
         accelerate the vesting of such shares in connection with the optionee's
         cessation of Service.

         2.       INCENTIVE OPTIONS

                  The terms and conditions  specified  below shall be applicable
to all Incentive  Options granted under the Plan.  Incentive Options may only be
granted to individuals who are Employees of the  Corporation.  Options which are
specifically  designated  as Non-  Statutory  Options when issued under the Plan
shall not be subject to such terms and conditions.

                  (a) Option  Price.  The  option  price per share of the Common
Stock subject to an Incentive  Option shall in no event be less than one hundred
percent  (100%) of the fair market  value of a share of Common Stock on the date
of grant.

                  (b)  Dollar  Limitation.   The  aggregate  fair  market  value
(determined as of the respective date or dates of grant) of the Common Stock for
which one or more options  granted to any Employee under this Plan (or any other
option plan of the Corporation or its parent or subsidiary corporations) may for
the first time become  exercisable as Incentive  Options during any one calendar
year shall not exceed the sum of One Hundred Thousand Dollars ($100,000). To the
extent the Employee holds two or more such options which become  exercisable for
the first  time in the same  calendar  year,  the  foregoing  limitation  on the
exercisability  of such options as incentive stock options under the Federal tax
laws  shall be  applied  on the basis of the order in which  such  options  were
granted.

                  (c) 10%  Stockholder.  If any  individual to whom an Incentive
Option is granted is at the time of such grant the owner of stock (as determined
under Section 424(d) of the Internal Revenue Code) possessing 10% or more of the
total  combined  voting  power  of  all  outstanding  classes  of  stock  of the
Corporation or any parent or subsidiary  corporation,  then the option price per
share  shall not be less than one  hundred  and ten  percent  (110%) of the fair
market  value per share of the Common  Stock on the grant  date,  and the option
term shall not exceed five (5) years, measured from the grant date.


                                       9.
<PAGE>

                  Except as modified by the preceding provisions of this Section
2, all the  provisions of the Plan shall be applicable to the Incentive  Options
granted hereunder.

         3.       STOCK APPRECIATION RIGHTS

                  (a) One or more Optionee  may, upon such terms and  conditions
as the Plan  Administrator  may  establish at the time of the option grant or at
any  time  thereafter,  be  granted  the  right to  surrender  all or part of an
unexercised  option in exchange for a distribution equal in amount to the excess
of (i) the fair market value (on the surrender  date) of the number of shares in
which the Optionee is at the time vested under the surrendered option or portion
thereof over (ii) the aggregate option price payable for such vested shares.  No
surrender of an option, however, shall be effective unless it is approved by the
Plan  Administrator.  If the surrender is so approved,  then the distribution to
which the option holder shall accordingly  become entitled under this subsection
3(a) may be made in shares of Common  Stock  valued at fair market value at date
of  surrender,  in cash,  or partly in shares  and  partly in cash,  as the Plan
Administrator shall in its sole discretion deem appropriate.

                  (b) If the  surrender  of an  option is  rejected  by the Plan
Administrator,  then the option holder shall retain  whatever  rights the option
holder had under the surrendered option (or surrendered  portion thereof) on the
surrender  date and may  exercise  such rights at any time prior to the later of
(i) the expiration of the 5 business-day  period following receipt by the option
holder  of the  rejection  notice  or (ii) the last day on which  the  option is
otherwise  exercisable in accordance with the terms of the instrument evidencing
such option,  but in no event may such rights be exercised at any time after ten
(10) years following the date of the option grant.

                  (c) Notwithstanding  the foregoing  provisions of this Section
3, one or more officers of the  Corporation  subject to the  short-swing  profit
restrictions  of the Federal  securities  laws may, in the Plan  Administrator's
sole  discretion,  be granted limited stock  appreciation  rights in tandem with
their  outstanding  options under this Article II. Each outstanding  option with
such a limited stock appreciation right shall automatically be cancelled, to the
extent  exercisable for vested shares of Common Stock,  upon the occurrence of a
Hostile  Take-Over,  and the  Optionee  shall in  return be  entitled  to a cash
distribution  from the  Corporation  in an amount equal to the excess of (i) the
fair market  value (on the  cancellation  date) of the number of shares in which
the  Optionee  is at the time vested  under the  cancelled  option or  cancelled
portion over (ii) the  aggregate  option price  payable for such vested  shares.
Such  cash  distribution  shall  be made  within  five (5)  days  following  the
consummation of the Hostile Take-Over. The Plan Administrator shall pre-approve,
at the time the limited  stock  appreciation  right is granted,  the  subsequent
exercise  of that  right in  accordance  with the  terms  of the  grant  and the
provisions  of  this  subsection  3(c).  No  additional  approval  of  the  Plan
Administrator  or the Board shall be  required at the time of the actual  option
surrender and cash distribution. The balance (if any) of each such option

                                       10.
<PAGE>

shall  continue  in full  force  and  effect  in  accordance  with the terms and
conditions of the instrument evidencing such grant.

                  (d) For  purposes of Section 3(c) above,  a Hostile  Take-Over
shall be deemed to occur in the event any  person or  related  group of  persons
(other than the Corporation or a person that directly or indirectly controls, is
controlled  by, or is under  common  control  with,  the  Corporation)  acquires
ownership of  securities  possessing  more than fifty percent (50%) of the total
combined voting power of the Corporation's  outstanding securities pursuant to a
tender or exchange offer made directly to the Corporation's  stockholders  which
the Board does not recommend such stockholders to accept.

                  (e)  The  shares  of  Common  Stock   subject  to  any  option
surrendered  or  cancelled  for an  appreciation  distribution  pursuant to this
Section V shall not be available for subsequent option grants or share issuances
under the Plan.

         4.       CORPORATE TRANSACTION

                  (a)  In  the   event   of  one  or  more   of  the   following
stockholder-approved transactions ("Corporate Transaction"):

                                    (i) a merger  or  acquisition  in which  the
         Corporation is not the surviving  entity,  except for a transaction the
         principal purpose of which is to change the State of incorporation;

                                    (ii) the sale, transfer or other disposition
         of  all  or  substantially  all of the  assets  of the  Corporation  in
         liquidation or dissolution of the Corporation; or

                                    (iii)  any  reverse   merger  in  which  the
         Corporation  is  acquired  but  continues  in  existence  as a separate
         entity,

                           each   outstanding   option   under  the  Plan  shall
automatically  accelerate so that each such option shall,  immediately  prior to
the  specified  effective  date for such  Corporate  Transaction,  become  fully
exercisable  with  respect to the total  number of shares of Common Stock at the
time subject to such option and may be exercised  for all or any portion of such
shares.  However,  an  outstanding  option shall not so accelerate if and to the
extent: (i) such option is, in connection with the Corporate Transaction, either
to be assumed by the successor  corporation  or parent thereof or to be replaced
with a  comparable  option  to  purchase  shares  of the  capital  stock  of the
successor  corporation or parent thereof or (ii) the acceleration of such option
is subject to other applicable  limitations imposed by the Plan Administrator in
the relevant option agreement.  The determination of comparability  under clause
(i) or  clause  (ii)  above  shall  be made by the Plan  Administrator,  and its
determination shall be final and conclusive.

                                       11.
<PAGE>

                  (b) Upon the  consummation of the Corporate  Transaction,  all
outstanding  options under the Plan shall immediately  terminate and cease to be
exercisable, except to the extent assumed by the successor corporation or parent
thereof.

                  (c) The  exercisability  as incentive  stock options under the
Federal tax laws of any options  accelerated  in  connection  with the Corporate
Transaction  shall remain subject to the applicable dollar limitation of Section
2(b).

                  (d) If the  outstanding  options under the Plan are assumed by
the successor  corporation (or parent  thereof) in the Corporate  Transaction or
are otherwise to continue in effect following such Corporate  Transaction,  then
each such assumed or continuing  option shall,  immediately after such Corporate
Transaction,  be  appropriately  adjusted to apply and pertain to the number and
class of securities or other property which would have been issued to the option
holder,  in  consummation  of the  Corporate  Transaction,  had the option  been
exercised   immediately  prior  to  such  Corporate   Transaction.   Appropriate
adjustments  shall also be made to the option price payable per share,  provided
the aggregate  option price payable for such  securities or other property shall
remain  the same.  In  addition,  the number  and class of  securities  or other
property  available for issuance  under the Plan following the  consummation  of
such Corporate Transaction shall be appropriately adjusted.

                  (e) The  grant of  options  under  this  Plan  shall in no way
affect  the  right of the  Corporation  to  adjust,  reclassify,  reorganize  or
otherwise  change its capital or business  structure  or to merge,  consolidate,
dissolve,  liquidate  or sell or  transfer  all or any part of its  business  or
assets.

         5.       CANCELLATION AND NEW GRANT OF OPTIONS

                  The Plan Administrator  shall have the authority to effect, at
any time and from time to time, with the consent of the affected Optionees,  the
cancellation  of any or all  outstanding  options under the Plan and to grant in
substitution  therefor new options under the Plan covering the same or different
numbers of shares of Common  Stock but having an option price per share not less
than (i) eighty-five  percent (85%) of the fair market value of the Common Stock
on such grant date or (ii) one hundred  percent (100%) of such fair market value
in the case of an Incentive Option.

         6.       EXTENSION OF EXERCISE PERIOD

                  The Plan  Administrator  shall have full power and  authority,
exercisable in its sole discretion,  to extend, either at the time the option is
granted or at any time while the option remains outstanding,  the period of time
for which the option is to remain exercisable following the Optionee's cessation
of Service from the twelve (12) month or shorter  period set forth in the option
agreement to such greater  period of time as the Plan  Administrator  shall deem
appropriate;   provided,  however,  that  in  no  event  shall  such  option  be
exercisable at any time after the specified expiration date of the option term.

                                       12.
<PAGE>

                                   ARTICLE III

                             STOCK ISSUANCE PROGRAM

         1.       TERMS AND CONDITIONS OF STOCK ISSUANCES

                  Shares may be issued under the Stock  Issuance  Program either
through  direct and immediate  purchases  without any  intervening  option grant
under the Option Grant Program or upon the  subsequent  exercise of  outstanding
options under the Option Grant Program. The issued shares will be evidenced by a
Restricted Stock Purchase  Agreement  ("Purchase  Agreement") that complies with
each of the terms and conditions of this Article III.

                  (a)      Share Price

                           (1) The purchase price per share will be fixed by the
Plan  Administrator,  but in no event will it be less than  eighty-five  percent
(85%) of the fair market value of the shares at the time of issuance.  Such fair
market  value  shall be  determined  in  accordance  with  Article  II,  Section
(1)(a)(3).

                           (2) Shares shall be issued under this Article III for
such consideration as the Plan Administrator  shall from time to time determine,
provided that in no event shall shares be issued for consideration other than:

                           (A)      cash or check payable to the Corporation; or

                           (B)      promissory note payable to the Corporation's
                                    order,  which may be subject to cancellation
                                    by the  Corporation in whole or in part upon
                                    such  terms  and   conditions  as  the  Plan
                                    Administrator shall specify.

                  (b)      Vesting Schedule

                           (1) The  interest of a  Participant  in the shares of
Common  Stock  issued to him or her under this  Article III may, in the absolute
discretion  of the Plan  Administrator,  be fully and  immediately  vested  upon
issuance or may vest in one or more  installments in accordance with the vesting
provisions  of  subsection  (b)(4).  Except as otherwise  provided in subsection
(b)(2),  the Participant may not transfer any of the Common Stock in which he or
she does not have a vested interest;  accordingly, all unvested shares issued to
the Participant  under this Article III Plan shall bear the  restrictive  legend
specified in subsection (c)(1),  until such legend is removed in accordance with
subsection  (c)(2).  The  Participant,  however,  shall have all the rights of a
stockholder  with respect to the issued shares of Common  Stock,  whether or not
such shares are vested.  Accordingly,  the  Participant  shall have the right to
vote such shares and to receive any regular cash

                                       13.
<PAGE>
dividends or other  distributions  paid or made with respect to such shares. Any
new,  substituted or additional  securities or other property  (including  money
paid other than as a regular cash dividend)  which the holder of unvested Common
Stock may have the right to receive by reason of a stock dividend,  stock split,
stock  combination,   recapitalization  or  similar  transaction  affecting  the
Corporation's outstanding securities without receipt of consideration, or in the
event of the conversion of the Corporation's  outstanding Common Stock into cash
or other shares or securities of the  Corporation or any other  corporation as a
result of a merger, consolidation, liquidation or other reorganization involving
the Corporation shall be issued to such holder,  subject to (i) the same vesting
requirements  under subsection  (b)(4)  applicable to his or her unvested Common
Stock and (ii) such escrow  arrangements  as the Plan  Administrator  shall deem
appropriate.

                           (2) As used in this Article III, the term  "transfer"
shall include (without limitation) any sale, pledge, encumbrance,  gift or other
disposition of any unvested  shares  acquired under the Stock Issuance  Program.
However,  the Participant  shall have the right to make a gift of one or more of
such  unvested  shares to his or her  spouse,  parents or children or to a trust
established  for such spouse,  parents or  children,  provided the donee of such
shares  delivers to the  Corporation a written  agreement to be bound by all the
provisions  of the Plan and other  instruments  executed by the  Participant  to
evidence  his or her  prior  acquisition  of  such  shares.  Any  gift  made  in
accordance with the foregoing  limitations shall not trigger the exercise of the
Corporation's repurchase rights under subsection (b)(3).

                           (3) In the event a Participant  should,  while his or
her interest in the acquired  shares remains  unvested,  (i) attempt to transfer
(other than by way of a  permissible  gift under  subsection  (b)(2)) any of the
unvested  shares or any interest  therein or (ii) cease to remain in Service (as
defined in Section  1(c)(4) of Article II) for any reason  whatsoever,  then the
Corporation  shall  have the  right to  repurchase  the  unvested  shares at the
original  purchase  price  paid by the  Participant  and the  Participant  shall
thereafter  have no further  stockholder  rights with respect to the repurchased
shares.

                           (4) Any shares of Common Stock issued under the Stock
Issuance Program which are not vested at the time of such issuance shall vest in
one or more  installments  thereafter.  The  elements of the  vesting  schedule,
namely the number of  installments in which the shares are to vest, the interval
or intervals  (if any) which are to lapse  between  installments  and the effect
which death,  disability or other event designated by the Plan  Administrator is
to have upon the vesting schedule, shall be determined by the Plan Administrator
and shall be specified in the Purchase Agreement executed by the Corporation and
the Participant at the time of issuance of the unvested shares.

                           (5)  The  Plan  Administrator  may in its  discretion
elect not to exercise,  in whole or in part, its repurchase  rights with respect
to any unvested  Common Stock or other assets which would  otherwise at the time
be subject to repurchase  pursuant to the provisions of subsection (b)(3).  Such
an election may be made at any time the

                                       14.
<PAGE>
repurchase right is outstanding and shall result in the immediate vesting of the
Participant's  interest in the shares of Common  Stock as to which the  election
applies.

                  (c)      Stock Legends

                           (1) Each certificate  representing unvested shares of
Common  Stock  (or  other  securities)  issued  under  the  Plan  shall  bear  a
restrictive legend substantially as follows:

               "The  securities  represented by this  certificate  are
         unvested  and  subject  to  repurchase  by  the   Corporation
         pursuant to the provisions of the  Restricted  Stock Purchase
         Agreement  between the Corporation and the registered  holder
         of the  securities  (or his  predecessor  in interest).  Such
         agreement grants certain repurchase rights to the Corporation
         in the event the  registered  holder (or his  predecessor  in
         interest)  terminates  his  employment  or  service  with the
         Corporation  prior to  vesting in the  securities.  A copy of
         such  agreement  is on file at the  principal  office  of the
         Corporation."

                           (2) As the  interest  of the  Participant  vests with
respect to any stock  certificate  representing  shares acquired under the Stock
Issuance Program, the Corporation shall, upon the Participant's delivery of such
certificate  during  the  period  or  periods  designated  each year by the Plan
Administrator,  issue  a new  certificate  for the  vested  shares  without  the
restrictive legend of subsection (c)(1) and a second certificate for the balance
of the shares with such legend. If the  Participant's  shares are held in escrow
at the time of vesting,  then the stock certificates for the vested shares shall
be released from escrow  (without the restrictive  legend of subsection  (c)(1))
and delivered to the Participant  during the period or periods designated by the
Plan  Administrator  at least  semi-annually  for such purpose and promptly upon
Participant's  cessation of Service. If the Corporation repurchases any unvested
shares of the Participant  pursuant to the provisions of subsection  (b)(3), the
Corporation  shall  at  the  time  the  repurchase  is  effected  deliver  a new
certificate,  without the restrictive legend of subsection (c)(1),  representing
the number of shares (if any) in which the  Participant  is vested and which are
accordingly no longer subject to repurchase by the  Corporation  pursuant to the
provisions of subsection (b)(3).

         2.       CORPORATE TRANSACTION

                  All of the Corporation's  outstanding  repurchase rights under
this Article III shall automatically  terminate,  and all shares of Common Stock
subject to such  repurchase  rights  shall  immediately  vest in full,  upon the
occurrence  of  a  Corporate   Transaction,   except  to  the  extent:  (i)  the
Corporation's  outstanding repurchase rights are to be assigned to the successor
corporation (or parent thereof) in connection with the Corporate  Transaction or
(ii) the termination of such repurchase  rights and the  acceleration of vesting
are precluded by other limitations  imposed by the Plan Administrator  under the
terms of the applicable Purchase Agreements.

                                       15.
<PAGE>

                                   ARTICLE IV

                                  MISCELLANEOUS

         1.       LOANS OR INSTALLMENT PAYMENTS

                  (a) The Plan Administrator may, in its discretion,  assist any
Optionee or Participant  (including an Optionee or Participant who is an officer
of the  Corporation)  in the  exercise  of one or more  options  granted to such
Optionee  under the Article II Option  Grant  Program or the  purchase of one or
more shares  issued to such  Participant  under the  Article III Stock  Issuance
Program by (i)  authorizing the extension of a loan from the Corporation to such
Optionee or  Participant  or (ii)  permitting the Optionee or Participant to pay
the  option  price  or  purchase  price  for  the  purchased   Common  Stock  in
installments  over a period of years.  The terms of any such loan or installment
method of payment  (including the interest rate and terms of repayment) shall be
upon such terms as the Plan  Administrator  shall  specify  in the stock  option
agreement or restricted  stock purchase  agreement.  Such loans and  installment
payments  may be made or  permitted  with or  without  security  or  collateral.
However,  the maximum credit  available to the Optionee or  Participant  may not
exceed the sum of (i) the aggregate  option price or purchase  price payable for
the purchased shares (less the par value) plus (ii) any federal and state income
and  employment  tax  liability  incurred  by the  Optionee  or  Participant  in
connection with such exercise or purchase.

                  (b) The Plan  Administrator  may, in its absolute  discretion,
determine that one or more loans  extended  under  subsection (a) above shall be
subject to  forgiveness  by the  Corporation in whole or in part upon such terms
and conditions as the Plan Administrator in its discretion deems appropriate.

         2.       AMENDMENT OF THE PLAN AND AWARDS

                  (a) The Board has the power and  authority  to amend or modify
the Plan in any or all  respects  whatsoever;  provided,  however,  that no such
amendment or modification may adversely affect the rights and obligations of the
option  holders with respect to their  outstanding  options under the Plan,  nor
adversely  affect the rights of any  Participant  with  respect to any  unvested
shares of Common Stock issued under the Plan prior to such Board action,  unless
the Optionee or Participant  consents to such  amendment.  In addition,  certain
amendments  may require  stockholder  approval  pursuant to  applicable  laws or
regulations.

                  (b) (i)  Options  to  purchase  shares of Common  Stock may be
granted  under the Option  Grant  Program and (ii) shares of Common Stock may be
issued under the Stock  Issuance  Program,  which are in excess of the number of
shares then available for issuance under the Plan,  provided (A) an amendment to
increase the maximum number of shares  issuable under the Plan is adopted by the
Board prior to the initial grant of any such option

                                       16.

<PAGE>

or  the  issuance  of  any  such  shares  and  is  thereafter  submitted  to the
Corporation's  shareholders  for  approval  and (B) any excess  shares  actually
issued under the Option Grant Program or the Stock Issuance  Program are held in
escrow until such stockholder approval is obtained. If such stockholder approval
is not  obtained  within  twelve (12)  months  from the date the  share-increase
amendment is adopted by the Board,  then (i) any unexercised  options granted on
the basis of such increase shall  terminate and cease to be exercisable and (ii)
the  Corporation  shall promptly refund to the  Participants  the purchase price
paid for any excess  shares  issued under the Plan and held in escrow,  together
with  interest  (at the  interest  rate  necessary  to avoid the  imputation  of
interest  income under the Federal tax laws) for the period the shares were held
in escrow.

         3.       EFFECTIVE DATE AND TERM OF PLAN

                  (a) The Plan was  initially  adopted by the Board on September
2, 1988 and approved by the Corporation's  stockholders on February 28, 1989. On
May 30, 1991,  the Board approved a  523,809-share  increase ** in the number of
shares of Common Stock issuable under the Plan, and the Plan was restated in its
entirety on September 6, 1991. Both the 523,809-share increase and the September
1991  restatement of the Plan were approved by the stockholders in January 1992.
On April 8, 1992, the Board adopted a new restatement of the Plan to (i) conform
the Plan to the  requirements of Rule 16b-3 under the Federal  securities  laws,
(ii) revise the events in which an acceleration of options would occur and (iii)
provide that the  non-employee  members of the Board would no longer be eligible
to  participate  in the  Plan.  The  stockholders  approved  the  amendment  and
restatement  on May 11, 1993.  On March 15, 1994,  the Board amended the Plan to
(i) increase the number of shares issuable thereunder by 450,000 shares and (ii)
limit the number of shares of Common Stock for which any one  individual  may be
granted stock options,  stock appreciation  rights and direct stock issuances in
the aggregate under the Plan after December 31, 1993 to a maximum of twenty five
percent (25%) of the number of shares from time to time  authorized for issuance
under the Plan (the "25% Limit"). The stockholders approved the amendment on May
24,  1994.  The Board  amended the Plan on December 14, 1995 to (i) increase the
maximum  number of shares of Common Stock  issuable  thereunder by an additional
850,000  shares and (ii)  replace the 25% Limit on the maximum  number of shares
for which any one individual may be granted stock  options,  stock  appreciation
rights and direct stock  issuances in the aggregate after December 31, 1993 with
a specific limit of 750,000 shares. The 850,000-share  increase became effective
when adopted by the Board.  The new 750,000 share limit on the maximum number of
shares  for  which  any one  individual  may be  granted  stock  options,  stock
appreciation  rights and direct stock  issuances in the aggregate under the Plan
became   effective  when  adopted  by  the  Board  on  December  14,  1995.  The
stockholders approved the amendment on May 16, 1996.

- --------
**/Adjusted  to reflect the  2.1-for-1  reverse  stock split to the  outstanding
Common Stock effected in January 1992.

                                       17.
<PAGE>


                  (b) The Plan was  amended  and  restated by the Board on March
19, 1997 (the "1997 Restatement") to effect the following changes:  (i) increase
the maximum  number of shares of Common Stock  authorized  for issuance over the
term of the Plan from 2,869,048 shares to 4,869,048 shares, (ii) extend the term
of the Plan from  September  2, 1998 to  December  31,  2002,  (iii)  render the
non-employee  Board members  eligible to receive  option grants and direct stock
issuances under the  Discretionary  Option Grant and Stock Issuance  Programs in
effect under the Plan,  (iii) allow  unvested  shares  issued under the Plan and
subsequently  repurchased  by the  Corporation  at the option  exercise price or
direct  issue  price paid per share to be reissued  under the Plan,  (iv) remove
certain  restrictions on the eligibility of non-employee  Board members to serve
as Plan  Administrator,  and (v)  effect a series of  additional  changes to the
provisions of the Plan  (including the  stockholder  approval  requirements)  in
order to take advantage of the recent amendments to Rule 16b-3 of the Securities
and Exchange Commission which exempts certain officer and director  transactions
under  the  Plan  from  the  short-swing  liability  provisions  of the  federal
securities laws. The 1997 Restatement is subject to stockholder  approval at the
1997  Annual   Meeting,   and  no  option  grants  made  on  the  basis  of  the
2,000,000-share increase shall become exercisable in whole or in part unless and
until  the  1997  Restatement  is  approved  by the  stockholders.  Should  such
stockholder  approval not be obtained,  then any options granted on the basis of
the 2,000,000-share  increase shall terminate without ever becoming  exercisable
for those shares,  and no further option grants or direct stock  issuances shall
be made on the basis of such share increase.  However,  option grants and direct
stock  issuances may continue to be made pursuant to the  provisions of the Plan
as in effect  immediately  prior to the 1997 Restatement  until the September 2,
1998 termination  date of the Plan.  Subject to the foregoing  limitations,  the
Plan  Administrator  may make option grants and direct stock issuances under the
Plan at any time before the date fixed herein for the termination of the Plan.

                  (c) The provisions of each restatement of the Plan shall apply
only to options granted under the Plan from and after the effective date of that
restatement. All options issued and outstanding under the Plan immediately prior
to each  such  restatement  shall  continue  to be  governed  by the  terms  and
conditions of the Plan (and the  instrument  evidencing  each such option) as in
effect on the date each such option was previously granted,  and nothing in that
restatement  shall be  deemed  to  affect  or  otherwise  modify  the  rights or
obligations  of the holders of such options with respect to the  acquisition  of
shares of Common Stock thereunder.

                  (d) The  sale  and  remittance  procedure  authorized  for the
exercise  of  outstanding  options  under the Plan  shall be  available  for all
options  granted under the Plan on or after the effective  date of the September
1991 restatement and all  non-statutory  options  outstanding  under the Plan on
such effective date. The Plan  Administrator may also allow such procedure to be
utilized in connection with one or more disqualifying  dispositions of Incentive
Option  shares   effected  after  the  effective  date  of  the  September  1991
restatement.


                                       18.
<PAGE>

                  (e) Unless sooner  terminated  in accordance  with a Corporate
Transaction,  the Plan shall  terminate  upon the  earlier of (i)  December  31,
2002*** or (ii) the date on which all shares  available  for issuance  under the
Plan shall have been issued or cancelled pursuant to the exercise,  surrender or
cash-out of the options  granted under the Option Grant Program and the issuance
or  repurchase  of  shares  under  the Stock  Issuance  Program.  If the date of
termination is determined under clause (i) above, then no options outstanding on
such date under Article II and no unvested shares issued and outstanding on such
date under  Article III shall be affected by the  termination  of the Plan,  and
each such  outstanding  option  and  unvested  share  issuance  will  thereafter
continue to have force and effect in accordance with the provisions of the stock
option  agreement  evidencing  each  such  Article  II option  and the  purchase
agreement evidencing each such unvested share issuance under Article III.

         4.       USE OF PROCEEDS

                  Any  cash  proceeds  received  by  the  Corporation  from  the
issuance of shares of Common Stock hereunder will be used for general  corporate
purposes.

         5.       WITHHOLDING

                  The  Corporation's  obligation  to  deliver  shares  upon  the
exercise  or  surrender  of any  options  granted  under  Article II or upon the
purchase  of any  shares  issued  under  Article  III  shall be  subject  to the
satisfaction  of all applicable  federal,  state and local income and employment
tax withholding requirements.

         6.       REGULATORY APPROVALS

                  (a) The  implementation of the Plan, the granting of any stock
option or stock appreciation right under the Option Grant Program,  the issuance
of any shares under the Stock Issuance Program, and the issuance of Common Stock
upon the exercise or surrender of the stock options or stock appreciation rights
granted  hereunder  shall be subject  to the  Corporation's  procurement  of all
approvals and permits  required by regulatory  authorities  having  jurisdiction
over the Plan, the options and stock  appreciation  rights granted under it, and
the Common Stock issued pursuant to it.

                  (b) No shares of Common  Stock or other assets shall be issued
or delivered under the Plan, unless and until, in the opinion of counsel for the
Corporation (or its successor in the event of any Corporate Transaction),  there
shall have been compliance  with all applicable  requirements of the Federal and
state securities exchange on which stock of

- --------
***/The extension of the term of the Plan from September 2, 1998 to December 31,
2002 is subject to stockholder approval at the 1997 Annual Meeting.

                                       19.

<PAGE>

the same  class is then  listed,  and all  other  requirements  of law or of any
regulatory bodies having jurisdiction over such issuance and delivery.

         7.       NO EMPLOYMENT/SERVICE RIGHTS

                  Neither the action of the  Corporation  in  establishing  this
Plan, nor any action taken by the Board of the Plan Administrator hereunder, nor
any provision of this Plan shall be construed so as to grant any  individual the
right to remain in the employ or service  of the  Corporation  (or any parent or
subsidiary corporation) for any period of specific duration, and the Corporation
(or  any  parent  or  subsidiary  corporation  retaining  the  services  of such
individual)  may terminate such  individual's  employment or service at any time
and for any reason, with or without cause.


                                       20.

<PAGE>

                                SPECIAL ADDENDUM

                            SHARED INVESTMENT PROGRAM


                  1.       PURPOSE

                           The Shared  Investment  Program  (the  "Program")  is
hereby implemented under the 1988 Restated Stock Plan, effective March 19, 1997.
The purpose of the Program is to provide the  Corporation's  officers  and other
key  employees  with the  opportunity  to  acquire  shares of Common  Stock as a
long-term  investment  and thereby  more  closely  align the  interests of those
individuals  with those of the  Corporation's  stockholders.  Specifically,  the
Program is intended to achieve the following purposes:

                           a.       more closely align the financial  rewards of
                                    participants   in  the   Program   with  the
                                    financial  rewards  realized  by  all  other
                                    holders of the Common Stock;

                           b.       increase the motivation of such participants
                                    to manage the Company as owners; and

                           c.       increase the ownership of Common Stock among
                                    the officers and other key  employees of the
                                    Company.

                           All capitalized  terms used in this Special  Addendum
shall, to the extent not specifically defined herein, have the meanings assigned
to those terms in the Plan.

                  2.       PARTICIPATION

                           The  individuals   eligible  to  participate  in  the
Program  shall be  limited  to the  officers  and  other  key  employees  of the
Corporation  listed in attached  Schedule I. Each such listed  individual  shall
become a participant in the Program to the extent he or she purchases all or any
portion of the number of shares of Common Stock  alloted to such  individual  in
attached  Schedule I. Any such purchase must be effected in accordance  with the
provisions of Section 3 below.

                  3.       PARTICIPATION

                           To  become  an  actual  participant  in  the  Program
("Participant"),  an  individual  listed in attached  Schedule I must effect the
purchase  of all or any  portion  of his or her  Common  Stock  allotment  under
Schedule I as follows:

                           a.       submit  a  completed   and  executed   Stock
                                    Purchase Agreement,  in the form approved by
                                    the Plan Administrator, which

<PAGE>

                                    incorporates  the  provisions of the Program
                                    applicable   to   the   purchased    shares,
                                    including (without limitation) the gain/loss
                                    sharing provisions of Section 6;

                           b.       execute   and   deliver   a    full-recourse
                                    promissory  note, in accordance with Section
                                    4 below,  in payment of the  purchase  price
                                    for the purchased shares;

                           c.       execute   and   deliver   a   stock   pledge
                                    agreement,  in  accordance  with  Section  4
                                    below,  as  collateral  for  the  promissory
                                    note; and

                           d.       satisfy    all    other     conditions    of
                                    participation specified in the Plan.

                           All  such   agreements  must  be  in  such  form  and
submitted  at such time as specified  by the Plan  Administrator.  No officer or
other key employee listed in attached  Schedule I is required to purchase any of
his or her Common Stock allotment or otherwise to participate in the Program.

                           The purchases  shall be effected in  accordance  with
the provisions of the Stock  Issuance  Program under the Plan, and the purchased
shares shall  reduce,  on a  one-for-one  basis,  the number of shares of Common
Stock  reserved  for  issuance  under the Plan.  The  purchased  shares shall be
fully-vested  upon  issuance  and  shall  not be  subject  to the  Corporation's
repurchase rights under Article III of the Plan.

                  4.       PAYMENT OF PURCHASE PRICE

                           The  purchase  price for all  shares of Common  Stock
issued under the Program shall be equal to one hundred  percent  (100%) of their
Fair Market  Value at the time of  purchase.  The  purchase  price shall be paid
through  the  Participant's   delivery  of  a  full-recourse   promissory  note,
substantially in the form of attached Exhibit A (the "Promissory Note"), payable
to the order of the Corporation.  The Promissory Note shall bear interest at the
minimum per annum rate, compounded semi-annually, required under the federal tax
laws to avoid the  imputation of  compensation  income to the  Participant.  The
Promissory  Note  shall  have a  maximum  term of five  (5)  years,  subject  to
acceleration in accordance  with the provisions of this Program.  The Promissory
Note shall be secured by the  Participant's  pledge of the purchased shares with
the Corporation. Accordingly, the Participant shall, at the time of the purchase
of those shares, execute and deliver to the Corporation a Stock Pledge Agreement
in the  form of  attached  Exhibit  B,  together  with the  certificate  for the
purchased shares accompanied by a duly-executed assignment of stock powers.



                                      A-2.

<PAGE>

                  5.       SALE OF PURCHASED SHARES

                           Each  Participant  shall be  permitted to sell all or
any portion of the shares of Common Stock he or she purchases  under the Program
(the "Purchased Shares"), subject, however, to the following restrictions:

                          a.        except  in the  event  of the  Participant's
                                    death or permanent disability (as defined in
                                    Internal  Revenue Code Section  22(e)(3)) or
                                    the occurrence of a Change in Control of the
                                    Corporation,  the  Participant  may not sell
                                    any portion of the  Purchased  Shares before
                                    the first  anniversary  of the date on which
                                    he  or  she  purchased   those  shares  (the
                                    "Purchase Date");

                          b.        the  Participant may not sell any portion of
                                    the  Purchased   Shares  unless  the  entire
                                    unpaid   balance   (principal   and  accrued
                                    interest) of his or her Promissory  Note has
                                    been   paid  or  the   sale   proceeds   are
                                    simultaneously  applied first to the payment
                                    of the principal  portion of the  Promissory
                                    Note  attributable  to those shares plus the
                                    accrued   and   unpaid   interest   on  that
                                    principal portion; and

                           c.       the  Participant  must  notify  the  Finance
                                    Department  of his or her  intention to sell
                                    the  Purchased  Shares  before  such sale is
                                    effected.

                           The Plan Administrator shall have the right to impose
restrictions on the timing, amount and form of sale of the Purchased Shares with
respect to any Participant, to the extent the Plan Administrator determines that
such restrictions are in the best interests of the Corporation.

                  6.       SHARING OF GAIN OR LOSS

                           If the Participant remains in Service until the first
anniversary of the Purchase Date, then the Corporation  shall share the loss (if
any) which the  Participant  may incur upon the subsequent sale of the Purchased
Shares.  The loss will be measured by the excess of (i) the purchase  price paid
for the Purchased Shares over (ii) the price at which those shares are sold. The
risk of loss on the Purchased Shares shall be allocated as follows:

                           a.       to the extent any  portion of the  Purchased
                                    Shares is sold before the third  anniversary
                                    of the Purchase Date, the Participant  shall
                                    be  responsible   for  one  hundred  percent
                                    (100%)  of the loss on that  portion  of the
                                    Purchased Shares; and



                                      A-3.
<PAGE>

                           b.       to the extent any  portion of the  Purchased
                                    Shares   is  sold  on  or  after  the  third
                                    anniversary   of  the  Purchase   Date,  the
                                    Participant  shall be  responsible  for only
                                    fifty  percent  (50%)  of the  loss  on that
                                    portion of the Purchased Shares.

                           The Corporation  shall also be entitled under certain
circumstances to share in the gain (if any) which the Participant may incur upon
the subsequent  sale of the Purchased  Shares.  The gain will be measured by the
excess  of (i) the price at which the  Purchased  Shares  are sold over (ii) the
purchase price paid for those shares.  The sharing of such gain on the Purchased
Shares shall be allocated as follows:

                           a.       to the extent any  portion of the  Purchased
                                    Shares is sold before the second anniversary
                                    of the Purchase Date, the Participant  shall
                                    only be  entitled to receive  fifty  percent
                                    (50%)  of the  gain on that  portion  of the
                                    Purchased  Shares,  and the remaining  fifty
                                    percent (50%) of the gain shall be paid over
                                    to the Corporation;

                           b.       to the extent any  portion of the  Purchased
                                    Shares  is  sold  on  or  after  the  second
                                    anniversary  of the Purchase Date but before
                                    the third anniversary of such Purchase Date,
                                    the  Participant  shall only be  entitled to
                                    receive  seventy-five  percent  (75%) of the
                                    gain  on  that  portion  of  the   Purchased
                                    Shares,   and  the   remaining   twenty-five
                                    percent (25%) of the gain shall be paid over
                                    to the Corporation; and

                            c.      to the extent any  portion of the  Purchased
                                    Shares   is  sold  on  or  after  the  third
                                    anniversary   of  the  Purchase   Date,  the
                                    Participant shall be entitled to receive one
                                    hundred  percent  (100%) of the gain on that
                                    portion of the Purchased Shares.

                           The  gain/loss  sharing  provisions of this Section 6
shall apply only to the extent the Purchased  Shares are sold by the Participant
and the sale proceeds are applied to payment of his or her Promissory Note.

                  7.       DEATH OR PERMANENT DISABILITY

                           Should the Participant cease Service by reason of his
or her death or permanent  disability at any time while there is an  outstanding
unpaid balance under his or her Promissory  Note,  then the  Participant (or the
representative  of  his or her  estate)  may  sell  all  or any  portion  of the
Purchased Shares,  subject only to the restrictions specified in subsections 5.b
and 5.c.  Upon the death of a  Participant,  her or his  Promissory  Note  shall
become immediately due and payable.


                                      A-4.
<PAGE>

                           With respect to any  Purchased  Shares sold after the
Participant's death or permanent disability and while there is an unpaid balance
outstanding  under his or her  Promissory  Note,  the  Participant  shall be not
responsible  for any loss  incurred  on the sale of those  Purchased  Shares and
shall be entitled to receive one hundred  percent (100%) of any gain realized on
the sale of the Purchased Shares.

                           This Section 7 shall not be applicable to any sale of
the Purchased  Shares effected (i) before the  Participant's  death or permanent
disability or (ii) after the payment of the entire balance owed under his or her
Promissory Note.

                  8.       OTHER CESSATION OF SERVICE

                           Should the  Participant's  Service  terminate for any
reason other than death or permanent  disability,  then the following provisions
shall apply:

                           - If the Participant's  Service  terminates after the
         first  anniversary  of the Purchase  Date,  then he or she shall remain
         subject to all of the terms and conditions of the Program, as if his or
         her Service had not terminated,  including  specifically  the gain/loss
         sharing provisions of Section 6.

                           - If the Participant's  Service terminates before the
         first anniversary of the Purchase Date, then he or she shall be:

                           a.       permitted  to  sell  the  Purchased  Shares,
                                    subject to the restrictions specified in the
                                    Section 5;

                           b.       responsible  for one  hundred  (100%) of the
                                    loss on the  sale of the  Purchased  Shares,
                                    whether the sale is effected before or after
                                    his or her Promissory Note is paid; and

                           c.       entitled to receive only fifty percent (50%)
                                    of the  gain on any  sale  of the  Purchased
                                    Shares  effected  while  there is an  unpaid
                                    balance outstanding on his or her Promissory
                                    Note, and the remaining  fifty percent (50%)
                                    of   that   gain   shall   be  paid  to  the
                                    Corporation simultaneously with the sale.

                           -  If  the  Participant's  Service  is  involuntarily
         terminated  by the  Corporation  for any  reason or if the  Participant
         voluntarily  resigns  from  Service,  then he or she will  have six (6)
         months to repay the entire outstanding balance on his or her Promissory
         Note.


                                      A-5.
<PAGE>

                  9.       CHANGE IN CONTROL

                           Immediately  prior to the consummation of a Change in
Control,  the  restrictions  on the sale of the  Purchased  Shares  specified in
Section 5.a shall lapse. In addition,  the following special provisions shall be
in effect for each  Participant  who continues in Service  through the effective
date of such Change in Control:

                           - each  such  Participant  shall  be  deemed  to have
         continued in Service until the first  anniversary  of the Purchase Date
         (should the Change in Control occur before the first anniversary of the
         Purchase Date), and

                           - each such Participant  shall be deemed to have sold
         the Purchased  Shares after the third  anniversary of the Purchase Date
         for  purposes  of Section 6 (should  the sale of the  Purchased  Shares
         occur before the third anniversary of the Purchase Date).

                           For  purposes  of the  Program,  a Change in  Control
shall  be  deemed  to  occur  upon a  change  in  ownership  or  control  of the
Corporation effected through any of the following transactions:

                                    a. the acquisition,  directly or indirectly,
         by any person or related group of persons  (other than the  Corporation
         or a person that directly or indirectly controls,  is controlled by, or
         is under common control with, the Corporation) of beneficial  ownership
         (within  the  meaning  of Rule  13d-3  of the 1934  Act) of  securities
         possessing  more than fifty percent (50%) of the total combined  voting
         power of the Corporation's  outstanding securities pursuant to a tender
         or exchange offer made directly to the Corporation's stockholders,

                                    b. a change in the  composition of the Board
         over a period of thirty-six (36) consecutive months or less such that a
         majority  of the  Board  members  ceases,  by  reason  of  one or  more
         contested   elections  for  Board   membership,   to  be  comprised  of
         individuals who either (A) have been Board members  continuously  since
         the  beginning of such period or (B) have been elected or nominated for
         election as Board members  during such period by at least a majority of
         the Board  members  described in clause (A) who were still in office at
         the time such election or nomination was approved by the Board, or

                                    c.   the   consummation   of   a   Corporate
         Transaction.



                                      A-6.
<PAGE>

                  10.      LOSS SHARING IMPLEMENTATION

                           Should  the  Participant  sell  any  portion  of  the
Purchased  Shares at a loss (as determined by the provisions of Section 6) while
his or her Promissory Note is outstanding, then the Corporation shall assume the
portion  (if any) of that  loss for  which the  Participant  is not  responsible
pursuant to the loss  sharing  provisions  of Section 6. The  Corporation  shall
satisfy such  obligation by delivering a check payable to the  Participant in an
amount equal to that portion ("Risk Sharing  Payment")  simultaneously  with the
Participant's payment of the outstanding unpaid balance of his or her Promissory
Note.

                           The  Corporation  anticipates  that the Risk  Sharing
Payment will constitute  compensation income to the Participant,  subject to the
Corporation's  collection of all applicable  income and  employment  withholding
taxes.  The Corporation  also  anticipates that the Risk Sharing Payment will be
deductible for federal income tax purposes as  compensation  in the taxable year
in which such  payment is made.  If the  Corporation  determines  that it is not
entitled  to a current  income tax  deduction  for the Risk  Sharing  Payment by
reason of the limitations imposed under Internal Revenue Code Section 162(m) and
the related Treasury Regulations, the Corporation will not make the Risk Sharing
Payment  to the  Participant  in  connection  with the  repayment  of his or her
Promissory Note.  Instead the Participant  shall be entitled to receive deferred
compensation  equal to the Risk  Sharing  Payment  at a time and in a form which
will allow the  Corporation  to obtain an income tax deduction for such payment.
The Plan  Administrator  shall have the sole  discretion to implement a deferred
compensation  arrangement  to the extent  necessary  or desirable to achieve the
intent of the preceding sentence.

                  11.      EFFECT OF PROGRAM

                  The Program  shall be governed by the  provisions of the Plan,
except as otherwise expressly stated in this Special Addendum.




                                      A-7.

<PAGE>
                                                                      APPENDIX B


                           MATRIX PHARMACEUTICAL, INC.
                        1991 DIRECTORS STOCK OPTION PLAN



                     AS AMENDED AND RESTATED MARCH 19, 1997

<PAGE>



                                    ARTICLE I

                               GENERAL PROVISIONS

PURPOSES OF THE PLAN

                  This 1991 Directors Stock Option Plan (the "Plan") is intended
to promote the interests of Matrix Pharmaceutical,  Inc., a Delaware corporation
(the "Corporation"),  by offering non-employee members of the Board of Directors
the  opportunity to  participate  in a special stock option program  designed to
provide  them  with  significant  incentives  to remain  in the  service  of the
Corporation.

ELIGIBILITY

                  A.  Each  non-employee  member of the  Corporation's  Board of
Directors  (the "Board")  shall be eligible to receive  automatic  option grants
pursuant to the provisions of Article II below.

                  B. In  addition  to the  automatic  option  grants  to be made
pursuant to the provisions of Article II below, non-employee Board members shall
also be  eligible  to  receive  option  grants  or  stock  issuances  under  the
Corporation's  1988  Restricted  Stock  Plan  or any  other  stock  plan  of the
Corporation or its Parent or Subsidiary corporations.

STOCK SUBJECT TO THE PLAN

                  A. The stock  issuable  under the Plan  shall be shares of the
Corporation's  common stock ("Common Stock").  Such shares may be made available
from  authorized  but unissued  shares of Common Stock or shares of Common Stock
reacquired by the Corporation. The aggregate number of issuable shares of Common
Stock shall not exceed 592,858 1 shares, subject to adjustment from time to time
in  accordance  with  subparagraph  D below.  Such share  reserve  reflects  the
2.1-for-1  reverse  stock  split of the  outstanding  Common  Stock  effected in
January 1992.

                  B. Should an option  expire or terminate  for any reason prior
to  exercise  in full,  the shares  subject to the  portion of the option not so
exercised  shall be  available  for  subsequent  option  grants under this Plan.
Shares  subject  to any  option  cancelled  in  accordance  with  the  automatic
cancellation  provisions of the Plan shall not be available for reissuance under
the Plan.

- --------
1/Includes  (i) the  200,000-share  increase  authorized by the Board on May 24,
1994 and approved by the  stockholders  at the 1995 Annual  Meeting and (ii) the
250,000-share  increase  authorized  by the Board on March 19, 1997,  subject to
stockholder approval at the 1997 Annual Meeting.

<PAGE>

                  C. Should the total number of shares at the time available for
grant under the Plan not be sufficient  for the  automatic  grants to be made at
that  particular  time to the  non-employee  Board  members,  then the available
shares shall be allocated  proportionately  among all the automatic grants to be
made at that time.

                  D.  In the  event  any  change  is made  to the  Common  Stock
issuable  under  the  Plan  by  reason  of  any  stock  split,  stock  dividend,
combination  of  shares,  exchange  of  shares  or other  change  affecting  the
outstanding  Common  Stock  as a class  without  the  Corporation's  receipt  of
consideration,  appropriate adjustments will be made to (i) the aggregate number
and/or class of shares of securities available for issuance under the Plan, (ii)
the number and/or class of securities to be made the subject of each  subsequent
automatic  grant and (iii) the number  and/or  class of  securities  purchasable
under each outstanding  option and the exercise price payable per share in order
to prevent the dilution or enlargement of benefits thereunder.

VALUATION

                  For  purposes  of  establishing  the option  price and for all
other  valuation  purposes  under the Plan,  the Fair Market  Value per share of
Common Stock on any relevant date shall be  determined  in  accordance  with the
following rules:

                (i) If the Common Stock is not at the time listed or admitted to
trading on any stock exchange but is traded on the Nasdaq National Market,  then
the Fair Market  Value shall be the  closing  selling  price per share of Common
Stock  on the  date in  question,  as such  price is  reported  by the  National
Association of Securities  Dealers,  Inc. on the Nasdaq  National  Market or any
successor  system.  If there is no reported closing selling price for the Common
Stock  on the  date in  question,  then the  closing  selling  price on the last
preceding date for which such quotation  exists shall be  determinative  of Fair
Market Value.

               (ii) If the Common  Stock is at the time  listed or  admitted  to
trading on any stock  exchange,  then the Fair Market Value shall be the closing
selling  price per share of Common  Stock on the date in  question  on the stock
exchange  serving as the primary  market for the Common Stock,  as such price is
officially quoted on such exchange. If there is no reported sale of Common Stock
on such  exchange on the date in  question,  then the Fair Market Value shall be
the closing  selling price on the exchange on the last  preceding date for which
such quotation exists.


                                       2.
<PAGE>

PARENT AND SUBSIDIARY CORPORATIONS

                  A.  A  corporation  shall  be  deemed  to be a  Parent  of the
Corporation if it is one of the corporations  (other than the Corporation) in an
unbroken chain of corporations  ending with the Corporation,  provided each such
corporation  (other than the  Corporation)  owns, at the time of  determination,
stock  possessing fifty percent (50%) or more of the total combined voting power
of all classes of stock in one of the other corporations in such chain.

                  B. A  corporation  shall be deemed to be a  Subsidiary  of the
Corporation if it is one of the corporations  (other than the Corporation) in an
unbroken chain of  corporations  beginning with the  Corporation,  provided each
such  corporation  (other than the last corporation in the unbroken chain) owns,
at the time of  determination,  stock  possessing fifty percent (50%) or more of
the total  combined  voting  power of all  classes  of stock in one of the other
corporations in such chain. For purposes of the Corporate Transaction provisions
of the Plan, the term  "Subsidiary"  shall also include any  partnership,  joint
venture or other  business  entity of which the  Corporation  owns,  directly or
indirectly  through another  subsidiary  corporation,  more than a fifty percent
(50%) interest in voting power, capital or profits.

                                       3.
<PAGE>

                                   ARTICLE II

                             AUTOMATIC GRANT PROGRAM

GRANT DATES

                  A. Initial  Grant.  Each  individual  who initially  becomes a
non-employee  Board  member at any time on or after the May 24,  1994  effective
date  of  this  plan   restatement,   whether  through  election  at  an  Annual
Stockholders Meeting or through appointment by the Board, shall automatically be
granted,  at the time of such initial  election or appointment,  a non-statutory
stock  option to  purchase  40,000  shares of  Common  Stock  upon the terms and
conditions  of this Article II,  provided  such  individual  has not  previously
served as an  employee of the  Corporation  or any Parent or  Subsidiary  of the
Corporation,.

                  B.  Annual  Grant.  On the  date of each  Annual  Stockholders
Meeting beginning with the first Annual Stockholders  Meeting held after the May
24,  1994  effective  date of this  plan  restatement,  each  individual  who is
re-elected  as a  non-employee  member of the Board at such Annual  Stockholders
Meeting (including  individuals who were initially elected as non-employee Board
members prior to May 24, 1994) shall receive an automatic option grant under the
Plan for 3,000  shares of Common  Stock,  provided  such  individual  has been a
member of the Board for at least six (6) months.

                  C. Special Grants.  The following  special option grants shall
be made under the Plan:

                           1. Each individual who was not eligible to receive an
         initial  option grant under the Plan for 23,810  shares of Common Stock
         when the Plan originally became effective on January 28, 1992 shall, in
         connection with the subsequent  cessation of his  affiliation  with the
         venture capital fund or other  investment  entity or corporate  partner
         with which he was affiliated on such earlier effective date,  receive a
         special  stock  option  grant for 40,000  shares of Common Stock on the
         later of (i) the May 24, 1994 effective  date of this plan  restatement
         or (ii) the date upon which such affiliation  ceases.  Such individual,
         however,  shall not be eligible to receive his or her next 3,000- share
         annual  option grant until the first Annual  Stockholders  Meeting held
         more  than  six  (6)  months  after  the  date  of his  or her  special
         40,000-share grant hereunder.

                           2. Each  individual  who  receives his or her initial
         automatic option grant under Paragraph A of this Grant Dates section at
         a time when such  individual  is otherwise  contractually  committed to
         transfer the economic  benefit of that grant and each subsequent  grant
         to the venture  capital  fund or other  investment  entity or corporate
         partner  with  which  he or  she is  affiliated, 

                                       4.

<PAGE>
         whether  as  partner,  principal,  stockholder  or  employee,  and  who
         subsequently  ceases to be affiliated  with the venture capital fund or
         other investment  entity or corporate  partner shall,  immediately upon
         such  cessation  of  affiliated  status,  receive a second stock option
         grant for 40,000  shares of Common  Stock.  Such  individual,  however,
         shall not be  eligible to receive  his or her next  3,000-share  annual
         option grant until the first Annual Stockholders Meeting held more than
         six (6) months after the date of his or her special  40,000-share grant
         hereunder.

                  All non-employee  Board members will be eligible for a special
option  grant in  accordance  with the  foregoing  criteria,  whether they first
joined the Board  before or after the May 24, 1994  effective  date of this plan
restatement.

                  D. The  40,000-share  limitation  on the  initial  and special
automatic  option grants and the 3,000-share  limitation on the automatic option
grants to be made annually to each non-employee Board member shall be subject to
periodic adjustment pursuant to the applicable provisions of Article I.

TERMS AND CONDITIONS OF GRANT

                  Each option  granted in accordance  with the  automatic  grant
provisions  of this Plan shall be evidenced by an  instrument in the form of the
prototype  non-statutory  stock option agreement attached to the Plan as Exhibit
A.  Accordingly,  each such  automatic  grant shall be subject to the  following
terms and conditions:

1.       Option Price.

         The option price per share shall be one hundred  percent  (100%) of the
Fair Market Value per share of Common Stock on the automatic grant date.

2.       Term and Exercisability of Options.

         a. Initial  Grant.  Provided the optionee  continues as a Board member,
each initial automatic option grant under Paragraph A of the Grant Dates section
shall  become  exercisable  for one or more of the  option  shares  in three (3)
successive annual installments as follows:

                           (i) The first  installment  equal to one-third of the
         total option shares shall become  exercisable on the first  anniversary
         of   the   grant   date,   provided   optionee   attends   all  of  the
         regularly-scheduled  Board  meetings  held during the  one-year  period
         measured from the grant date. To the extent that optionee  attends less
         than all of such  meetings,  the option shall lapse as to the number of
         shares  determined by multiplying  one-third of the total option shares
         by a fraction,  the  numerator of which is the number of such 

                                       5.

<PAGE>
         meetings not attended by the optionee  during such one-year  period and
         the  denominator  of which is the total  number of such  meetings  held
         during that  period.  Any option  shares as to which the option  lapses
         shall no longer be subject to such option or  otherwise  available  for
         purchase by the optionee.

                           (ii) The second  installment  equal to an  additional
         one- third of the total option shares shall become  exercisable  on the
         second anniversary of the grant date,  provided optionee attends all of
         the regularly- scheduled Board meetings held during the one-year period
         measured  from the first  anniversary  of the grant date. To the extent
         that optionee attends less than all of such meetings,  the option shall
         lapse as to the number of shares determined by multiplying one-third of
         the total option  shares by a fraction,  the  numerator of which is the
         number  of such  meetings  not  attended  by the  optionee  during  the
         applicable  one-year  period and the  denominator of which is the total
         number of such meetings  held during such period.  Any option shares as
         to which the option lapses shall no longer be subject to such option or
         otherwise available for purchase by the optionee.

                           (iii)  The  third  installment  equal  to  the  final
         one-third of the total option  shares shall become  exercisable  on the
         third  anniversary of the grant date,  provided optionee attends all of
         the regularly-scheduled  Board meetings held during the one-year period
         measured from the second  anniversary  of the grant date. To the extent
         that optionee attends less than all of such meetings,  the option shall
         lapse as to the number of shares determined by multiplying one-third of
         the total option  shares by a fraction,  the  numerator of which is the
         number  of such  meetings  not  attended  by the  optionee  during  the
         applicable  one-year  period and the  denominator of which is the total
         number of such meetings  held during such period.  Any option shares as
         to which the option lapses shall no longer be subject to such option or
         otherwise available for purchase by the optionee.

                  As the option becomes exercisable for one or more installments
of the option shares,  the installments  shall accumulate,  and the option shall
remain  exercisable  for the  accumulated  installments  until the expiration or
sooner termination of the option term.

         b. Annual  Grant.  Each annual  option  grant under  Paragraph B of the
Grant Dates section shall become  exercisable in its entirety one (1) year after
the grant date, provided optionee attends all of the  regularly-scheduled  Board
meetings held during that one-year  period.  To the extent that optionee attends
less than all of such  meetings,  the  option  shall  lapse as to the  number of
shares  determined  by  multiplying  the  number  of total  option  shares  by a
fraction,  the numerator of which is the number of such meetings not attended by
the optionee during the applicable  one-year period and the denominator of which
is the total number of such meetings held during such period.  Any option shares
as to which the  option  lapses  shall no longer be  subject  to such  option or
otherwise available for purchase 6.

<PAGE>
by the optionee.  To the extent the option becomes  exercisable  for one or more
option shares,  such option shall remain  exercisable  for such shares until the
expiration or sooner termination of the option term.

         c. Special  Grant.  Provided the optionee  continues as a Board member,
any special  automatic option grant made to that individual under Paragraph C of
the Grant Dates section (the "Special Option") shall become  exercisable for the
option shares in accordance with the following provisions:

                           - One-third of the total  option  shares shall become
         exercisable  upon the later of (i) the first  anniversary  of the grant
         date of his or her initial  automatic option grant under Paragraph A of
         the Grant Dates  section  ("the  Initial Grant Date") or (ii) the grant
         date of the Special Option,  provided that in either event the optionee
         attended all of the regularly- scheduled Board meetings held during the
         one-year  period  measured  from the Initial  Grant Date. To the extent
         that optionee attended less than all of such meetings, the option shall
         immediately  lapse as to the number of shares determined by multiplying
         one-third of the total option  shares by a fraction,  the  numerator of
         which is the  number of such  meetings  not  attended  by the  optionee
         during such one-year  period and the  denominator of which is the total
         number of such meetings  held during that period.  Any option shares as
         to which the option lapses shall no longer be subject to such option or
         otherwise available for purchase by the optionee.

                           - An additional  one-third of the total option shares
         shall become  exercisable upon the later of (ii) the second anniversary
         of the Initial Grant Date or (ii) the grant date of the Special Option,
         provided  optionee  attended  all  of  the  regularly-scheduled   Board
         meetings  held  during  the  one-year  period  measured  from the first
         anniversary  of the  Initial  Grant Date.  To the extent that  optionee
         attended less than all of such meetings,  the option shall  immediately
         lapse as to the number of shares determined by multiplying one-third of
         the total option  shares by a fraction,  the  numerator of which is the
         number  of such  meetings  not  attended  by the  optionee  during  the
         applicable  one-year  period and the  denominator of which is the total
         number of such meetings  held during such period.  Any option shares as
         to which the option lapses shall no longer be subject to such option or
         otherwise available for purchase by the optionee.

                           - The  final  one-third  of the total  option  shares
         shall become exercisable upon the later of (i) the third anniversary of
         the  Initial  Grant Date or (ii) the grant date of the  Special  Grant,
         provided  optionee  attended  all  of  the  regularly-scheduled   Board
         meetings  held  during the  one-year  period  measured  from the second
         anniversary  of the  Initial  Grant Date.  To the extent that  optionee
         attended less than all of such meetings,  the option 

                                       7.
<PAGE>

         shall  immediately  lapse as to the  number  of  shares  determined  by
         multiplying  one-third  of the total option  shares by a fraction,  the
         numerator of which is the number of such  meetings not attended  by the
         optionee  during the applicable  one-year period and the denominator of
         which is the total number of such meetings held during such period. Any
         option  shares as to which the option lapses shall no longer be subject
         to such option or otherwise available for purchase by the optionee.

                  For any special  option grant made under  Paragraph C.1 of the
Grant  Dates  section to an  individual  who did not in fact  receive an initial
automatic option grant on the original effective date of the Plan, the foregoing
schedule  shall be adjusted so that the term "Initial Grant Date" shall mean the
original  January  28,  1992  effective  date  of the  Plan,  even  though  such
individual did not receive an initial automatic option grant at that time.

                  As the  Special  Option  becomes  exercisable  for one or more
installments of the option shares,  the installments  shall accumulate,  and the
Special Option shall remain  exercisable for the accumulated  installments until
the expiration or sooner termination of the option term.

         d. Term. Each option  outstanding  under the Plan on March 19, 1997 and
each option  subsequently  granted  under the Plan shall have a term of ten (10)
years measured from the automatic grant date,  whether or not optionee continues
to serve as a Board Member,  subject to earlier termination in connection with a
Corporate Transaction or Hostile Take-Over as hereinafter provided.

3.       Exercise of Option.

         Upon exercise of the option,  the option price for the purchased shares
shall  become  immediately  payable in one of the  alternative  forms  specified
below:

                  (i) cash or check payable to the Corporation's order; or

                  (ii)  shares  of Common  Stock  held by the  optionee  for the
         requisite  period  necessary  to  avoid a charge  to the  Corporation's
         reported  earnings  and  valued  at Fair  Market  Value  on the date of
         exercise; or

                  (iii) any  combination  of the  foregoing so long as the total
         payment equals the aggregate option price for the purchased shares; or

                  (iv)  payment  effected  through  a  broker-dealer   sale  and
         remittance  procedure  pursuant to which the Optionee (I) shall provide
         irrevocable instructions to a  Corporation-designated  broker-dealer to
         effect  the  immediate  sale of the  purchased  shares and remit to the
         Corporation, out of the sale proceeds available on the settlement date,
         an amount equal to the 
                                       8.

<PAGE>

         aggregate  option  price  payable  for the  purchased  shares  plus all
         applicable Federal and State income and employment taxes required to be
         withheld by the  Corporation  by reason of such purchase and (II) shall
         provide  directives to the Corporation to deliver the  certificates for
         the purchased shares directly to such broker-dealer.

4.       Limited-Transferability.

         The option may, in  connection  with the  optionee's  estate  plan,  be
assigned  in whole or in part  during  the  optionee's  lifetime  to one or more
members of the optionee's immediate family or to a trust established exclusively
for one or more such family members.  The assigned portion may only be exercised
by the  person or  persons  who  acquire a  proprietary  interest  in the option
pursuant to the assignment.  The terms  applicable to the assigned portion shall
be the  same as  those  in  effect  for the  option  immediately  prior  to such
assignment  and shall be set forth in such  documents  issued to the assignee as
the Corporation may deem appropriate.  Should the optionee die while holding the
option,  then that option shall be transferred in accordance with the optionee's
will or the laws of descent and distribution.

5.       Effect of Termination of Board Membership.

         a. Should the optionee  cease to serve as a Board Member for any reason
(other than death) while  holding an  automatic  option grant under this Article
II, then such  optionee  shall have until the  expiration  of the ten  (10)-year
option  term in which to  exercise  such  option for any or all of the shares of
Common Stock for which the option is exercisable at the time of such  optionee's
cessation of Board  service.  However,  the option shall,  immediately  upon the
optionee's  cessation of service as a Board  Member,  terminate  and cease to be
outstanding  for any and all shares of Common  Stock for which the option is not
otherwise at that time exercisable.

         b. Should an optionee  die while  serving as a Board  Member,  then any
outstanding  automatic  grant held by the  optionee  at the time of death may be
subsequently exercised, for any or all of the shares at the time subject to that
option, by the personal representative of the optionee's estate or by the person
or persons to whom the option is transferred  pursuant to the optionee's will or
in accordance with the laws of descent and distribution. The option shall remain
so exercisable until the expiration of the ten (10)-year option term.

         e. Each  automatic  option  grant shall  terminate  and cease to remain
exercisable  for  any of the  option  shares  upon  the  expiration  of the  ten
(10)-year  option  term,  subject  to  earlier   termination  upon  a  Corporate
Transaction or Hostile Take-Over as hereinafter provided.


                                       9.
<PAGE>

         f. For purposes of the Plan, the optionee shall be deemed to serve as a
Board  Member  for so long as he or she  continues  to serve as a member  of the
Board or  Directors  or as a member of the board of  directors  of any Parent or
Subsidiary of the Corporation.

6.       Stockholder Rights.

         An option  holder shall have none of the rights of a  stockholder  with
respect to any shares covered by the automatic grant until such individual shall
have  exercised  the  option,  paid the  option  price  and been  issued a stock
certificate for the purchased shares.

7.       Remaining  Terms.  The remaining terms and conditions of each automatic
option grant shall be as set forth in the prototype  Non-Statutory  Stock Option
Agreement attached as Exhibit A to the Plan.

CORPORATE TRANSACTION

                  A.  In  the  event  of  any  of  the  following   transactions
("Corporate Transaction"):

                  (i) a merger or  consolidation in which the Corporation is not
         the surviving entity, except for a transaction the principal purpose of
         which is to change the State of the Corporation's incorporation; or

                  (ii) a sale of all or substantially  all of the  Corporation's
         assets in complete liquidation or dissolution of the Corporation; or

                  (iii)  any  reverse  merger in which  the  Corporation  is the
         surviving  entity  but in which  all of the  Corporation's  outstanding
         voting stock is transferred to the acquiring entity or its wholly-owned
         subsidiary;

                  then each automatic option grant at the time outstanding under
the Plan and not  otherwise at the time fully  exercisable  shall  automatically
accelerate  so that each such option shall,  immediately  prior to the specified
effective  date for the Corporate  Transaction,  become fully  exercisable  with
respect  to the total  number of shares of Common  Stock at the time  subject to
such  option  and may be  exercised  for  all or any  portion  of  such  shares.
Immediately  following  the  consummation  of such  Corporate  Transaction,  all
outstanding options under this Plan shall terminate and cease to be exercisable,
except to the extent assumed by the successor corporation or its parent company.

                  B. To the extent one or more options  understanding  under the
Plan at the time of the  Corporate  Transaction  are  assumed  by the  successor
corporation or its parent company, then each of those options shall, immediately
after such Corporate Transaction, be appropriately adjusted to apply and pertain
to the number and class of securities which would have been issued to the option
holder in the consummation of such Corporate

                                       10.
<PAGE>

Transaction had that option been exercised  immediately  prior to such Corporate
Transaction.  Appropriate  adjustments  shall also be made to the  option  price
payable per share, provided the aggregate option price shall remain the same.

                  C. The automatic  grants in effect under this Plan shall in no
way affect the right of the  Corporation  to adjust,  reclassify,  reorganize or
otherwise  change its capital or business  structure  or to merge,  consolidate,
dissolve,  liquidate  or sell or  transfer  all or any part of its  business  or
assets.

CHANGE IN CONTROL/HOSTILE TAKEOVER

                  A. Each automatic option grant  outstanding  under the Plan at
the  time  of a  Change  in  Control  of  the  Corporation  shall  automatically
accelerate  so that each such option shall,  immediately  prior to the specified
effective date for the Change in Control,  become fully exercisable with respect
to the total number of shares of Common Stock at the time subject to such option
and may be exercised  for all or any portion of such shares at any time prior to
the expiration or sooner termination of the option term.

                  B. Upon the occurrence of a Hostile Take-Over,  each automatic
option  grant at the time  outstanding  under the Plan  shall  automatically  be
cancelled in return for a cash  distribution  from the  Corporation in an amount
equal to the excess of (i) the Take- Over Price of the shares of Common Stock at
the time subject to the cancelled option (whether or not the option is otherwise
at the time exercisable for such shares) over (ii) the aggregate  exercise price
payable for such shares.  The cash  distribution  payable upon such cancellation
shall  be  made  to the  option  holder  within  five  (5)  days  following  the
consummation  of the  Hostile  Take-Over.  Stockholder  approval  of  this  1997
restatement  of  the  Plan  shall   constitute   pre-approval   of  each  option
subsequently  granted  with  such a  automatic  cancellation  provision  and the
subsequent cancellation of that option in accordance with the provisions of this
Paragraph B. No  additional  approval of the Board shall be required at the time
of the actual option cancellation and cash distribution.

                  C. For purposes of this Article II, the following  definitions
shall be in effect:

                           A Change in Control shall be deemed to occur if:

                                    (i) any person or  related  group of persons
         (other than the  Corporation  or a person that  directly or  indirectly
         controls,  is  controlled  by, or is under  common  control  with,  the
         Corporation)  directly  or  indirectly  acquires  beneficial  ownership
         (within the  meaning of Rule 13d-3 of the  Securities  Exchange  Act of
         1934) of  securities  possessing  more than forty  percent (40%) of the
         total combined voting power of the Corporation's outstanding securities
         pursuant  to  a  tender  or  exchange   offer  made   directly  to  the
         Corporation's stockholders; or

                                       11.
<PAGE>

                                    (ii) there is a change in the composition of
         the Board over a period of twenty-four (24) consecutive  months or less
         such that a majority of the Board members  ceases,  by reason of one or
         more proxy contests for the election of Board members,  to be comprised
         of  individuals  who either (A) have been  Board  members  continuously
         since  the  beginning  of such  period  or (B)  have  been  elected  or
         nominated for election as Board members  during such period by at least
         two-thirds of the Board members  described in clause (A) who were still
         in office at the time such election or  nomination  was approved by the
         Board.

                                    A Hostile Take-Over shall be deemed to occur
         in the event any person or related  group of  persons  (other  than the
         Corporation  or a person  that  directly  or  indirectly  controls,  is
         controlled  by,  or is under  common  control  with,  the  Corporation)
         directly  or  indirectly  acquires  beneficial  ownership  (within  the
         meaning  of Rule  13d-3  of the  Securities  Exchange  Act of  1934) of
         securities  possessing  more  than  forty  percent  (40%) of the  total
         combined  voting  power  of the  Corporation's  outstanding  securities
         pursuant  to  a  tender  or  exchange   offer  made   directly  to  the
         Corporation's  stockholders  which the Board  does not  recommend  such
         stockholders to accept.

                                    The  Take-Over  Price  per  share  shall  be
         deemed  to be equal to the  greater  of (a) the Fair  Market  Value per
         share  on the  date  of the  option  cancellation  or (b)  the  highest
         reported price per share paid in effecting such Hostile Take-Over.

                  D. The shares of Common Stock subject to each option cancelled
in connection  with the Hostile  Take-Over shall not be available for subsequent
issuance under this Plan.


                                       12.

<PAGE>


                                   ARTICLE III

                            MISCELLANEOUS PROVISIONS

AMENDMENT OF THE PLAN

                  The  Board  shall  have  complete  and  exclusive   power  and
authority to amend or modify the Plan in any or all respects.  However,  no such
amendment or modification shall adversely affect any rights and obligations with
respect to any stock options at the time  outstanding  under the Plan unless the
optionee  consents to such  amendment  or  modification.  In  addition,  certain
amendments  may require  stockholder  approval  pursuant to  applicable  laws or
regulations.

EFFECTIVE DATE AND TERM OF PLAN

                  A. The Plan was  adopted  by the  Board in  December  1991 and
approved by the  Corporation's  stockholders  in January  1992.  The Plan became
effective  on January 28,  1992,  the date when the Common  Stock  first  became
subject  to the  registration  requirements  of  Section  12 of  the  Securities
Exchange Act of 1934.  The Plan was  subsequently  amended on March 31, 1992. On
May 24, 1994, the Plan was restated, subject to stockholder approval at the 1995
Annual  Meeting,  to (i) increase  the maximum  number of shares of Common Stock
authorized for issuance  under the Plan by an additional  200,000  shares,  (ii)
increase the number of shares for which an initial  automatic option grant is to
be made under  Paragraph A of the Grant  Dates  section  from  23,810  shares to
40,000  shares and the number of shares  for which the annual  automatic  option
grants are to made  under  Paragraph  B of the Grant  Dates  section  from 2,858
shares to 3,000 shares each,  (iii)  provide for a special  40,000-share  option
grant to each non-employee Board member upon his or her subsequent  cessation of
affiliate  status with any venture  capital fund or other  investment  entity or
corporate  partner  with  which  he or she was  affiliated  at the time the Plan
originally  became effective on January 28, 1992 or which required him or her to
transfer to such entity the economic  benefit of any previous  option  grants to
such  individual  and (iv)  effect  certain  additional  changes  to the Plan to
clarify the  benefits  available  to  participants.  Nothing in the May 24, 1994
restatement  shall have any effect or impact upon any prior  option  grants made
under the Plan,  and those prior option grants shall  continue to be governed by
the terms and provisions of the option agreements evidencing those grants.

                  B. The Plan was amended and restated by the Board on March 19,
1997 (the "1997 Restatement") to effect the following changes:  (i) increase the
maximum  number of shares of Common Stock  authorized for issuance over the term
of the Plan from 342 858  shares to  592,858  shares,  (ii)  allow  each  option
outstanding  under the Plan on or after March 19, 1997 to remain  outstanding as
to any otherwise  exercisable  option  shares for the full ten (10)-year  option
term,  whether or not the  optionee  continues to serve as a Board  Member,  and
(iii) effect a series of changes to the  provisions of the Plan  (including  the
stockholder  approval  requirements)  in order to take  advantage  of the recent
amendments

                                       13.
<PAGE>

to Rule 16b-3 of the Securities and Exchange  Commission  which exempts  certain
officer and director  transactions under the Plan from the short-swing liability
provisions of the federal  securities  laws. The 1997  Restatement is subject to
stockholder  approval at the 1997 Annual  Meeting,  and no option grants made on
the basis of the 250,000-share  increase shall become exercisable in whole or in
part unless and until the 1997  Restatement  is  approved  by the  stockholders.
Should such  stockholder  approval not be obtained,  then any options granted on
the basis of the  250,000-share  increase shall terminate  without ever becoming
exercisable for those shares,  and no further option grants shall be made on the
basis of such share increase.  In addition,  all options  outstanding  under the
Plan on or after  March  19,  1997  will  remain  subject  to a  maximum  twelve
(12)-month exercise period following the optionee's  cessation of Board service.
In the absence of such  stockholder  approval,  option  grants  shall,  however,
continue to be made pursuant to the  provisions  of the  Automatic  Option Grant
Program in effect under the Plan immediately prior to the 1997 Restatement.  All
option grants made prior to the 1997  Restatement  shall remain  outstanding  in
accordance  with  the  terms  and  conditions  of  the  respective   instruments
evidencing those options,  and nothing in the 1997  Restatement  (other than the
extension of the  post-service  exercise period) shall be deemed to modify or in
any way affect those outstanding options or issuances.

                  C. The Plan shall  terminate upon the earliest to occur of (i)
December 2, 2001 unless sooner  terminated by the Board,  (ii) the date on which
all shares available for issuance under the Plan shall have been issued pursuant
to the  exercise of the  automatic  grants made  hereunder  or (iii) the date on
which all  outstanding  options are  cashed-out in  connection  with the Hostile
Takeover  provisions of the Plan. If the date of termination is determined under
clause (i) above,  then any option grants  outstanding on such date shall not be
affected  by the  termination  of the Plan and shall  continue to have force and
effect in accordance  with the  provisions of the  instruments  evidencing  such
grants.

CASH PROCEEDS

                  Any cash proceeds received by the Corporation from the sale of
shares  pursuant to the  automatic  grants made under the Plan shall be used for
general corporate purposes.

REGULATORY APPROVALS

                  The  implementation  of the Plan,  the  granting of any option
hereunder, and the issuance of Common Stock upon the exercise of any such option
shall be subject to the  Corporation's  procurement of all approvals and permits
required  by  regulatory  authorities  having  jurisdiction  over the Plan,  the
options granted under it and the Common Stock issued pursuant to it.


                                       14.
<PAGE>

NO IMPAIRMENT OF RIGHTS

                  Nothing in this Plan or any  automatic  grant made pursuant to
the Plan  shall  be  construed  or  interpreted  so as to  affect  adversely  or
otherwise  impair the right of the Corporation or its stockholders to remove any
optionee from service on the Board at any time in accordance with the provisions
of applicable law.



                                       15.

<PAGE>


                                    EXHIBIT A



<PAGE>


                                                          AUTOMATIC OPTION GRANT


                           MATRIX PHARMACEUTICAL, INC.

                      NON-STATUTORY STOCK OPTION AGREEMENT


                  AGREEMENT  made  this  day  of , 199  by  and  between  Matrix
Pharmaceutical, Inc., a corporation organized and existing under the laws of the
State of Delaware (the "Company"), and 1~ (the "Optionee").

                                   WITNESSETH:

RECITALS

                  A. The Company's  Board of Directors (the "Board") has adopted
the Company's  1991  Director  Stock Option Plan (the "Plan") for the purpose of
providing an equity  incentive for individuals to serve as non-employee  members
of the Board.

                  B. Optionee is a non-employee  Board member who is entitled to
receive an option to acquire  shares of the Company's  common  stock,  par value
$0.01 per share (the "Common  Stock"),  pursuant to the  automatic  option grant
program  implemented  for  non-employee  Board  members  under  the  Plan.  This
Agreement is executed pursuant to, and is intended to carry out the purposes of,
the Plan in  connection  with the  automatic  option grant made to such Optionee
thereunder.

                  C. The granted option is intended to be a non-statutory  stock
option  which does not satisfy the  requirements  of Section 422 of the Internal
Revenue Code.

                  D. For purposes of this Agreement,  the following  definitions
shall be in effect:

                  Board  Member:  The  Optionee  shall be  deemed  to be a Board
         Member for so long as such individual continues to serve as a member of
         the  Company's  Board of Directors  (the "Board") or as a member of the
         board of directors of any Parent or Subsidiary Corporation.

                  Fair Market  Value:  The Fair Market Value per share of Common
         Stock on any date in question  shall be determined  in accordance  with
         the following provisions:


<PAGE>


                  (i) If the Common  Stock is not at the time listed or admitted
         to trading on any stock  exchange but is traded on the Nasdaq  National
         Market,  then the Fair Market Value shall be the closing  selling price
         per share of Common  Stock on the date in  question,  as such  price is
         reported by the National Association of Securities Dealers, Inc. on the
         Nasdaq National Market or any successor system. If there is no reported
         closing  selling  price for the Common  Stock on the date in  question,
         then the closing  selling  price on the last  preceding  date for which
         such quotation exists shall be determinative of Fair Market Value.

                  (ii) If the Common  Stock is at the time listed or admitted to
         trading on any stock exchange,  then the Fair Market Value shall be the
         closing selling price per share of Common Stock on the date in question
         on the stock  exchange  serving  as the  primary  market for the Common
         Stock, as such price is officially quoted on such exchange. If there is
         no  reported  sale of  Common  Stock  on such  exchange  on the date in
         question, then the Fair Market Value shall be the closing selling price
         on the  exchange on the last  preceding  date for which such  quotation
         exists.

                  Parent  Corporation:  A  corporation  shall be  deemed to be a
         Parent  Corporation  if it is one of the  corporations  (other than the
         Company) in an unbroken chain of corporations  ending with the Company,
         provided each such  corporation  (other than the Company)  owns, at the
         time of determination,  stock possessing fifty percent (50%) or more of
         the total  combined  voting power of all classes of stock in one of the
         other corporations in such chain.

                  Subsidiary Corporation:  A corporation shall be deemed to be a
         Subsidiary Corporation if it is one of the corporations (other than the
         Company)  in an  unbroken  chain  of  corporations  beginning  with the
         Company,   provided  each  such   corporation   (other  than  the  last
         corporation in the unbroken chain) owns, at the time of  determination,
         stock  possessing  fifty  percent  (50%) or more of the total  combined
         voting  power of all classes of stock in one of the other  corporations
         in such chain.

TERMS

                  1.  Grant of Option.  On , 199 (the  "Grant  Date"),  there is
hereby  automatically  granted to Optionee,  pursuant to the  provisions  of the
Plan, a stock option to purchase up to 3,000 shares of Common Stock (the "Option
Shares") upon the terms and  conditions  set forth in this  Agreement and in the
Plan,  and such terms and  conditions of the Plan are hereby  incorporated  into
this  Agreement by reference and made a part hereof as if expressly  included in
this  Agreement.  The Option Shares shall be purchasable in accordance with such
terms and conditions at the option  exercise price of $__________ per share (the
"Option Price").



                                       2.

<PAGE>

                  2.  Option  Term.  This  option  shall have a term of ten (10)
years measured from the Grant Date and shall accordingly  expire at the close of
business on _______________________,  200 (the "Expiration Date"), unless sooner
terminated in accordance with Paragraph 7A or 7C of this Agreement.

                  3. Limited  Transferability.  This option,  together  with the
special stock  appreciation  right under  Paragraph 7C, may, in connection  with
Optionee's  estate  plan,  be  assigned  in whole or in part  during  Optionee's
lifetime to one or more  members of  Optionee's  immediate  family or to a trust
established  exclusively  for one or more  such  family  members.  The  assigned
portion may only be exercised by the person or persons who acquire a proprietary
interest in the option pursuant to the assignment.  The terms  applicable to the
assigned portion shall be the same as those in effect for the option immediately
prior to such  assignment.  Any  other  attempt  to  assign,  pledge,  transfer,
hypothecate   or  otherwise   dispose  of  this  option  or  the  special  stock
appreciation  right  during  Optionee's  lifetime,  and any  levy of  execution,
attachment or similar  process on this option or such stock  appreciation  right
shall be null and void. Should the Optionee die while holding this option,  then
this option shall be transferred in accordance  with Optionee's will or the laws
of inheritance and distribution.

                  4.  Exercisability.  This option shall become  exercisable  in
accordance  with the terms of  attached  Exhibit  I. Once  this  option  becomes
exercisable  for one or more Option Shares in  accordance  with Exhibit I, those
Option Shares shall accumulate, and this option shall remain exercisable for the
accumulated Option Shares until the Expiration Date or sooner termination of the
option term under Paragraph 7A or 7C.

                  5. Cessation of Board Membership. Should the Optionee cease to
serve as a Board Member  while this option is  outstanding,  then the  following
provisions shall become applicable:

                           (i) Should the  Optionee's  service as a Board Member
         terminate  for any  reason  other  than  death  while  this  option  is
         outstanding,  then Optionee shall have until the Expiration Date of the
         option  term to exercise  this  option for any Option  Shares for which
         this  option  is  exercisable  on the date of such  cessation  of Board
         service.  However,  this option shall,  immediately upon the Optionee's
         cessation  of  service  as a Board  Member,  terminate  and cease to be
         outstanding  with respect to any Option Shares for which this option is
         not  otherwise  at  that  time   exercisable  in  accordance  with  the
         provisions of this Agreement.

                           (ii) Should the Optionee die while serving as a Board
         Member,  then the personal  representative of the Optionee's estate (or
         the person or persons to whom the option is transferred pursuant to the
         Optionee's will or in accordance  with the laws of  inheritance)  shall
         have the

                                       3.

<PAGE>

         right to exercise  this  option for any or all of the Option  Shares at
         the time  subject to such  option.  Such right  shall  lapse,  and this
         option shall cease to be  exercisable,  upon the Expiration Date of the
         option term.

                           (iii) In no event may this  option be  exercised  for
         any Option  Shares after the  specified  Expiration  Date of the option
         term or the sooner termination of this option under Paragraph 7A or 7C.

                  6.       Adjustment in Option Shares.

                  A.  In the  event  any  change  is made  to the  Common  Stock
issuable  under  the  Plan  by  reason  of  any  stock  split,  stock  dividend,
combination  of  shares,  exchange  of  shares  or other  change  affecting  the
outstanding   Common  Stock  as  a  class  without  receipt  of   consideration,
appropriate  adjustments shall  automatically be made to the number and/or class
of  securities  subject to this option and the Option Price payable per share in
order  to  reflect  such  transaction  and  thereby  preclude  the  dilution  or
enlargement of benefits hereunder.

                  B. If this  option is assumed in  connection  with a Corporate
Transaction  under Paragraph 7, then this option shall,  immediately  after such
Corporate  Transaction,  be  appropriately  adjusted to apply and pertain to the
number and class of  securities  which would have been issued to Optionee in the
consummation  of such  Corporate  Transaction  had this  option  been  exercised
immediately prior to such Corporate Transaction.  Appropriate  adjustments shall
also be made to the Option  Price  payable  per share,  provided  the  aggregate
Option Price shall remain the same.

                  7.       Corporate   Transaction/Change   in   Control/Hostile
                           Take-Over.

                  A.  In the  event  of any of  the  following  transactions  (a
"Corporate Transaction"):

                           (i) a merger or  acquisition  in which the Company is
         not the  surviving  entity,  except  for a  transaction  the  principal
         purpose of which is to change the State of the Company's incorporation,
         or

                           (ii)  a  sale  of  all  or  substantially  all of the
         Corporation's  assets in complete  liquidation  or  dissolution  of the
         Corporation; or

                           (iii) any reverse  merger in which the Company is the
         surviving entity but in which all of the Company's  outstanding  voting
         stock  is  transferred  to the  acquiring  entity  or its  wholly-owned
         subsidiary;


                                       4.

<PAGE>

                  the   exercisability   of  this  option  shall   automatically
accelerate  so that  such  option  shall,  immediately  prior  to the  specified
effective  date for the Corporate  Transaction,  become fully  exercisable  with
respect to all the Option  Shares at the time  subject to this option and may be
exercised  for all or any  portion of such  shares.  Immediately  following  the
consummation of the Corporate Transaction, this option shall terminate and cease
to be outstanding,  except to the extent assumed by the successor corporation or
its parent company.

                  B. In  connection  with any Change in Control of the  Company,
the  exercisability of this option shall  automatically  accelerate so that such
option shall,  immediately prior to the specified  effective date for the Change
in Control,  become fully  exercisable  with respect to all the Option Shares at
the time subject to this option and may be  exercised  for all or any portion of
such shares.  The option as so accelerated  shall remain  exercisable  until the
expiration  or sooner  termination  of the option  term.  For  purposes  of this
Agreement, a Change in Control shall be deemed to occur in the event:

                           (i) any  person or related  group of  persons  (other
         than the Company or a person that directly or indirectly  controls,  is
         controlled by, or is under common  control with, the Company)  directly
         or indirectly acquires beneficial ownership (within the meaning of Rule
         13d-3 of the Securities Exchange Act of 1934, as amended) of securities
         possessing  more than forty percent (40%) of the total combined  voting
         power of the Company's  outstanding  securities pursuant to a tender or
         exchange offer made directly to the Company's stockholders; or

                           (ii)  there is a  change  in the  composition  of the
         Board over a period of twenty-four (24) consecutive months or less such
         that a majority of the Board members  ceases,  by reason of one or more
         proxy  contests for the election of Board  members,  to be comprised of
         individuals who either (A) have been Board members  continuously  since
         the  beginning of such period or (B) have been elected or nominated for
         election as Board members during such period by at least  two-thirds of
         the Board  members  described in clause (A) who were still in office at
         the time such election or nomination was approved by the Board.

                  C. Should a Hostile Take-Over of the Company occur at any time
while this  option is  outstanding,  then this  option  shall  automatically  be
cancelled  upon the effective  date of such Hostile  Take-Over in exchange for a
cash  distribution  from the Company.  Such  distribution  shall be in an amount
equal to the excess of (i) the Take-Over  Price of the shares of Common Stock at
the time  subject  to this  option  (whether  or not the  option  is at the time
otherwise  exercisable for such shares) over the aggregate  Option Price payable
for such  shares.  The cash  distribution  shall  be made  within  five (5) days
following the effective  date of the Hostile  Take-Over,  and no approval of the
Board shall be required

                                       5.

<PAGE>

in connection  with such  cancellation  and  distribution.  For purposes of this
Paragraph 7C, the following definitional provisions shall be in effect:

                           A Hostile  Take-Over  shall be deemed to occur in the
         event (i) any  person  or  related  group of  persons  (other  than the
         Company or a person that directly or indirectly controls, is controlled
         by, or is under common control with, the Company) acquires ownership of
         securities  possessing  more  than  forty  percent  (40%) of the  total
         combined voting power of the Company's outstanding  securities pursuant
         to  a  tender  or  exchange   offer  made  directly  to  the  Company's
         stockholders  which the Board does not recommend such  stockholders  to
         accept.

                           The  Take-Over  Price per share shall be deemed to be
         equal to the greater of (a) the Fair  Market  Value per share of Common
         Stock  on the  date  of the  option  cancellation  or (b)  the  highest
         reported price per share paid by the acquiring  entity in effecting the
         Hostile Take-Over.

                  D. This Agreement shall not in any way affect the right of the
Company to adjust,  reclassify,  reorganize  or  otherwise  make  changes in its
capital or business structure or to merge, consolidate,  dissolve,  liquidate or
sell or transfer all or any part of its business or assets.

                  8. Privilege of Stock  Ownership.  Optionee shall not have any
stockholder rights with respect to the Option Shares until such individual shall
have  exercised the option,  paid the Option Price for the purchased  shares and
been issued a stock certificate for such shares.

                  9.       Manner of Exercising Option.

                  A. In order to  exercise  this  option for one or more  Option
Shares for which this  option is at the time  exercisable,  Optionee  (or in the
case of exercise after Optionee's death, the Optionee's executor, administrator,
heir or legatee, as the case may be) must take the following actions:

                           (i)  Execute  and  deliver  to the  Secretary  of the
         Company a  written  notice  of  exercise  (the  "Exercise  Notice")  in
         substantially the form of Exhibit II attached hereto.

                           (ii) Pay the aggregate Option Price for the purchased
         shares in one or more of the following alternative forms:

                                    - full payment in cash or check made payable
                  to the Company's order;

                                       6.

<PAGE>

                                    - full  payment  in shares  of Common  Stock
                  held by the Optionee  for the  requisite  period  necessary to
                  avoid  a  charge  to  the  Company's  earnings  for  financial
                  reporting  purposes  and  valued at Fair  Market  Value on the
                  Exercise Date;

                                    - full payment in a combination of shares of
                  Common Stock held for the requisite  period necessary to avoid
                  a charge to the  Company's  earnings for  financial  reporting
                  purposes and valued at Fair Market Value on the Exercise  Date
                  and cash or check; or

                                    - full payment through a sale and remittance
                  procedure  pursuant to which the  Optionee  (a) shall  provide
                  irrevocable  instructions  to a  Company-designated  brokerage
                  firm to effect the immediate sale of the purchased  shares and
                  remit to the Company,  out of the sale  proceeds  available on
                  the settlement  date,  sufficient funds to cover the aggregate
                  exercise price payable for the purchased  shares and (b) shall
                  concurrently  provide  directives  to the  Company  to deliver
                  certificates   for  the  purchased  shares  directly  to  such
                  brokerage firm in order to complete the sale transaction.

                           (iii)    Furnish   to   the    Company    appropriate
         documentation  that the  person or  persons  exercising  the option (if
         other than Optionee) have the right to exercise this option.

                  B. For purposes of this Agreement,  the Exercise Date shall be
the date on which the Exercise  Notice shall have been delivered to the Company.
Except to the extent the sale and remittance  procedure  specified  above may be
utilized in connection  with the exercise of this option,  payment of the Option
Price for the purchased shares must accompany such notice.

                  C. As soon as  practical  after the exercise of this option in
accordance  with the  provisions  of this  Agreement,  the Company shall mail or
deliver  to or on  behalf  of the  Optionee  (or any  other  person  or  persons
exercising this option) a stock certificate representing the purchased shares.

                  D. In no event may this option be exercised for any fractional
shares.

                  10.  Legality of Issuance.  The Company shall not be obligated
to sell or issue any Option  Shares  pursuant to this  Agreement if such sale or
issuance  might,  in the  opinion  of the  Company  and the  Company's  counsel,
constitute a violation by the Company of any applicable law or regulation.


                                       7.

<PAGE>

                  11. Binding  Effect.  Subject to the  limitations set forth in
Paragraph 3 of this Agreement, this Agreement shall be binding upon and inure to
the benefit of the executors, administrators,  heirs, legal representatives, and
successors and assigns of the parties hereto;  provided,  however, that Optionee
may not assign any of  Optionee's  rights  under  this  Agreement  other than as
permitted under Paragraph 3.

                  12. No Impairment of Rights.  Nothing in this  Agreement or in
the Plan  shall be  deemed to impair or  otherwise  restrict  the  rights of the
Company or its  stockholders  to remove the Optionee  from the Board at any time
pursuant to the provisions of applicable law. 

                  13.  Governing  Law. This  Agreement  shall be governed by and
construed in accordance  with the laws of the State of California  applicable to
contracts entered into and wholly to be performed within the State of California
by California residents.

                  14. Notices.  All notices and other  communications under this
Agreement  shall be in  writing.  Unless and until the  Optionee  is notified in
writing to the contrary,  all notices,  communications and documents directed to
the Company shall, if not personally delivered,  be mailed to the Company at the
following address:

                           Matrix Pharmaceutical, Inc.
                           34700 Campus Drive
                           Fremont, CA  94555

                  Unless  and until the  Company is  notified  in writing to the
contrary,  all notices,  communications  and documents intended for the Optionee
shall, if not personally  delivered,  be mailed to Optionee's last known address
as shown on the Company's books.  Notices and communications  shall be mailed by
registered mail,  return receipt  requested,  postage prepaid.  All mailings and
deliveries related to this Agreement shall be deemed received only when actually
received,  unless properly mailed by registered mail, return receipt  requested,
in which event they shall be deemed received two days after the date of mailing.

                  15.  Construction.  This  Agreement  and the option  evidenced
hereby are issued pursuant to the automatic grant program for non-employee Board
Members in effect  under the Plan and shall be subject to the express  terms and
provisions of the Plan applicable to such automatic grants.



                                       8.

<PAGE>

                  IN WITNESS  WHEREOF,  Matrix  Pharmaceutical,  Inc. has caused
this Agreement to be executed on its behalf by its  duly-authorized  officer and
the Optionee has executed  this  Agreement,  all on the day and year first above
written.


                                      MATRIX PHARMACEUTICAL, INC.

                                      By __________________________________

                                      Title _______________________________

                                      _____________________________________
                                                   OPTIONEE

                                     Address ______________________________

                                             ______________________________


                                       9.

<PAGE>

                                    EXHIBIT I

                                EXERCISE SCHEDULE

                  The option shall become  exercisable  in  accordance  with the
following terms and conditions,  provided the Optionee continues in service as a
Board Member.

                  The  option  shall  become  exercisable  for all of the Option
         Shares one (1) year after the Grant Date, provided the Optionee attends
         all of the regularly-scheduled Board meetings held during that one-year
         period.  To the extent that the Optionee  attends less than all of such
         meetings,  this option  shall  lapse as to the number of Option  Shares
         determined  by  multiplying  the total  number  of  Option  Shares by a
         fraction,  the  numerator  of  which  is the  number  of such  meetings
         attended by the Optionee during the applicable  one-year period and the
         denominator  of which is the total number of such  meetings held during
         that period.  Any Option Shares as to which this option so lapses shall
         no longer be subject to such option or otherwise available for purchase
         by the Optionee.

                  In no event  shall  this  option  become  exercisable  for any
additional  Option Shares  following the date the Optionee  ceases to serve as a
Board Member.



<PAGE>

                                   EXHIBIT II


                       NOTICE OF EXERCISE OF STOCK OPTION


                  I hereby notify Matrix  Pharmaceutical,  Inc. (the  "Company")
that I elect to purchase  shares of the Company's  Common Stock (the  "Purchased
Shares")  pursuant to that  certain  option (the  "Option")  granted to me on to
purchase  up to 3,000  shares of such Common  Stock at an option  price of $ per
share (the "Option Price").

                  Concurrently  with the delivery of this Exercise Notice to the
Secretary of the Company, I shall hereby pay to the Company the Option Price for
the Purchased  Shares in accordance with the provisions of my agreement with the
Company  evidencing the Option and shall deliver whatever  additional  documents
may be required by such agreement as a condition for exercise.  Alternatively, I
may utilize the special broker-dealer sale and remittance procedure specified in
my agreement to effect the payment of the Option Price for the Purchased Shares.


_____________________________       _________________________________________
Date                                Optionee

                         Address:   _________________________________________

                                    _________________________________________



       Print name in exact manner
       it is to appear on the
       stock certificate:          _________________________________________

                                   _________________________________________



      Address to which certificate 
      is to be sent, if different
      from address above:          _________________________________________

                                   _________________________________________

                                   _________________________________________



      Social Security Number:      _________________________________________
 

<PAGE>
                                                                      APPENDIX C

                           MATRIX PHARMACEUTICAL, INC.
                                      PROXY
                  Annual Meeting of Stockholders, June 25, 1997

                This Proxy is Solicited on Behalf of the Board of
                           Matrix Pharmaceutical, Inc.

         The undersigned revokes all previous proxies,  acknowledges  receipt of
the Notice of the Annual  Meeting of  Stockholders  to be held June 25, 1997 and
the Proxy  Statement and appoints  Edward E. Luck and Craig R. McMullen and each
of them, the Proxy of the undersigned,  with full power of substitution, to vote
all shares of Common Stock of Matrix Pharmaceutical,  Inc. (the "Company") which
the  undersigned  is  entitled  to vote,  either on his or her own  behalf or on
behalf of any entity or entities,  at the Annual Meeting of  Stockholders of the
Company to be held at the Company's  headquarters,  34700 Campus Drive, Fremont,
California  94555  on  Wednesday,  June  25,  1997 at 10:00  A.M.  (the  "Annual
Meeting"),  and at any adjournment or postponement  thereof, with the same force
and effect as the undersigned  might or could do if personally  present thereat.
The shares  represented  by this Proxy shall be voted in the manner set forth on
the reverse side.

         1. To elect the  following  directors  to serve  until the next  annual
meeting of stockholders and until their successors are elected and qualified:

                                                                  WITHHOLD
                                                                 AUTHORITY
                                                  FOR             TO VOTE

                  J. Stephan Dolezalek           _____             _____
                  Edward E. Luck                 _____             _____
                  John E. Lyons                  _____             _____
                  Julius L. Pericola             _____             _____
                  Alan E. Salzman                _____             _____

         2.       FOR   AGAINST   ABSTAIN
                                                To approve certain amendments to
                                                the  Company's  1988  Restricted
                                                Stock    Plan   (the    "Plan"),
                                                including (i) an increase in the
                                                maximum   number  of  shares  of
                                                common  stock   authorized   for
                                                issuance  under  the  Plan by an
                                                additional  2,000,000 shares and
                                                (ii) the  extension  of the term
                                                of the Plan  from  September  2,
                                                1998 to December 31, 2002.

         3.       FOR   AGAINST   ABSTAIN
                                                To approve certain amendments to
                                                the  Company's   1991  Directors
                                                Stock     Option    Plan    (the
                                                "Directors Plan"),  including an
                                                increase in the  maximum  number
                                                of  shares   of   common   stock
                                                authorized  for  issuance  under
                                                the   Directors   Plan   by   an
                                                additional 250,000 shares.

         4.       FOR   AGAINST   ABSTAIN

                                                To    ratify    the   Board   of
                                                Director's  selection of Ernst &
                                                Young   LLP  to   serve  as  the
                                                Company's            independent
                                                accountants  for the fiscal year
                                                ending December 31, 1997.

         In accordance with the discretion of the proxyholders,  to act upon all
matters  incident to the  conduct of the  meeting and upon other  matters as may
properly come before the meeting.

         The  Board of  Directors  recommends  a vote FOR each of the  directors
listed  above and a vote FOR the other  proposals.  This  Proxy,  when  properly
executed,  will be voted as specified  above. If no  specification is made, this
Proxy will be voted IN FAVOR OF the election of the  directors  listed above and
IN FAVOR OF the other proposals.

         Please print the name(s)  appearing on each share  certificate(s)  over
         which you have voting authority:

         -----------------------------------------------------------------------
                                 (Print name(s) on certificate)


         Please sign your name:                                Date:

         ----------------------------------------------------  -----------------
                      (Authorized Signature(s))





© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission