MATRIX PHARMACEUTICAL INC/DE
SC 13G, 1998-12-16
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                           Matrix Pharmaceutical Inc.
        -----------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
        -----------------------------------------------------------------
                         (Title of Class of Securities)

                                    576844104
                              --------------------
                                 (CUSIP Number)

                                December 9, 1998
        ----------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

      / X / Rule 13d-1(b)
      /   / Rule 13d-1(c)
      /   / Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the  liabilities of the section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



<PAGE>


                                  SCHEDULE 13G
                               CUSIP NO. 576844104

1.    Names of Reporting Persons.
      I.R.S. Identification Nos. of above persons (entities only).

      Quaker Capital Management Corporation
      --------------------------------------------------------------------------

2.    Check the Appropriate Box if a Member of a Group (a)
            -----
      (b)     X
            -----

3.    SEC Use Only
                        --------------------------------------------------------

4.    Citizenship or Place of Organization                          Pennsylvania
                                                                    ------------

Number of         5.    Sole Voting Power                                942,500
Shares                                                              ------------
Beneficially      6.    Shared Voting Power                            1,336,800
Owned by                                                            ------------
Each Reporting    7.    Sole Dispositive Power                           942,500
Person With:                                                        ------------
                  8.    Shared Dispositive Power                       1,336,800
                                                                    ------------

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

                                                                       2,279,300
                                                                    ------------

10.   Check if the Aggregate Amount in Row (9) Excludes Certain
      Shares
                                                                    ------------

      The Reporting  Person disclaims  beneficial  ownership of 2,218,800 shares
      owned by its clients.

11.   Percent of Class Represented by Amount in Row (9)                   10.31%
                                                                    ------------

12.   Type of Reporting Person                                                IA
                                                                    ------------


                               Page 2 of 6 Pages
<PAGE>


                                 SCHEDULE 13 G
                              CUSIP NO. 576844104


Item 1.

      (a)   Name of Issuer

            Matrix Pharmaceutical Inc.
            --------------------------------------------------------------------

      (b)   Address of Issuer's Principal Executive Offices

            34700 Campus Drive, Fremont, California 94555
            --------------------------------------------------------------------
Item 2.

      (a)   Name of Persons Filing

            Quaker Capital Management Corporation
            --------------------------------------------------------------------

      (b)   Address of Principal Business Office or, if none, Residence

            401 Wood Street, Suite 1300, Pittsburgh, PA  15222
            --------------------------------------------------------------------

      (c)   Citizenship

            Pennsylvania, USA
            --------------------------------------------------------------------

      (d)   Title of Class of Securities

            Common Stock
            --------------------------------------------------------------------

      (e)   CUSIP Number

            576844104
            --------------------------------------------------------------------



                               Page 3 of 6 Pages
<PAGE>


                                  SCHEDULE 13 G
                               CUSIP NO. 576844104


Item 3.     If this  statement  is  filed   pursuant  to  ss.ss.240.13d-1(b)  or
            240.13d-2(b) or (c), check whether the person filing is a:

   (a)    /    /  Broker of dealer registered under section 15 of the Act;

   (b)    /    /  Bank as defined in section 3(a)(6) of the Act;

   (c)    /    /  Insurance  company as defined in section  3(a)(19) of the Act;

   (d)    /    /  Investment  company   registered   under   section   8  of the
                  Investment Company Act of 1940;

   (e)    / X  /  An  investment  adviser  in accordance with ss.240.13d-1(b)(l)
                  (ii)(E);

   (f)    /    /  An  employee  benefit  plan or  endowment  fund  in accordance
                  with ss.240.13d-1(b)(1)(ii)(F);

   (g)    /    /  A parent holding  company or control person in accordance with
                  ss.240.13d-1(b)(1)(ii)(G);

   (h)    /    /  A  savings  association  as  defined  in  Section  3(b) of the
                  Federal Deposit Insurance Act;

   (i)    /    /  A church plan  that is  excluded  from  the  definition  of an
                  investment  company under section  3(c)(14) of the  Investment
                  Company Act of 1940;

   (j)    /    /  Group, in accordance with ss.240.13d-1((b)(l)(ii)(J)

Item 4.     Ownership.

            Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

      (a)   Amount beneficially owned:                                 2,279,300
                                                                 ---------------

      (b)   Percent of class:                                             10.31%
                                                                 ---------------

                               Page 4 of 6 Pages
<PAGE>

                                  SCHEDULE 13 G
                               CUSIP NO. 576844104


      (c) Number of shares as to which the person has:

            (i)   Sole power to vote or to direct the
                  vote                                                   942,500
                                                                      ----------

            (ii)  Shared power to vote or to direct
                  the vote                                             1,336,800
                                                                      ----------

            (iii)Sole power to dispose or to direct
                  the vote                                               942,500
                                                                      ----------

            (iv)  Shared power to dispose or to direct
                  the disposition of                                   1,336,800
                                                                      ----------

Item 5.     Ownership of Five Percent or Less of a Class

            If this  statement  is being filed to report the fact that as of the
date hereof,  the reporting person has ceased to be the beneficial owner of more
than five percent of the class of securities, check the following:
                                                                      ----------

Item 6.     Ownership of More than Five Percent on Behalf of
            Another Person

            2,218,000  of the shares with  respect to which this report is filed
are owned by a variety of investment  advisory clients of the Reporting  Person,
which  clients are entitled to receive  dividends  on and the proceeds  from the
sale of such shares. No client is known to own more than 5% of the class.

Item 7.     Identification and Classification of the Subsidiary Which
            Acquired the Security Being Reported on by the Parent Holding
            Company

            Not applicable.


                               Page 5 of 6 Pages
<PAGE>

                                  SCHEDULE 13 G
                               CUSIP NO. 576844104



Item 8.     Identification and Classification of Members of the Group

            Not applicable.

Item 9.     Notice of Dissolution of Group

            Not applicable.

Item 10.    Certification

            By signing  below I certify  that,  to the best of my knowledge  and
belief,  the  securities  referred  to above were  acquired  and are held in the
ordinary  course  of  business  and were not  acquired  and are not held for the
purpose of or with the effect of  changing  or  influencing  the  control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.


                                    SIGNATURE

            After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.


Date:  December 15, 1998                  /s/Mark G.Schoeppner
                                          ------------------------------
                                          Mark G. Schoeppner
                                          President



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