MATRIX PHARMACEUTICAL INC/DE
SC 13G/A, 1999-02-16
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*

                           MATRIX PHARMACEUTICAL, INC.
        -----------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
        -----------------------------------------------------------------
                         (Title of Class of Securities)

                                    576844104
                              --------------------
                                 (CUSIP Number)

                                December 31, 1998
        ----------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

      / X / Rule 13d-1(b)
      /   / Rule 13d-1(c)
      /   / Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the  liabilities of the section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


<PAGE>
                                  SCHEDULE 13G
                               CUSIP NO. 576844104

1.    Names of Reporting Persons.
      I.R.S. Identification Nos. of above persons (entities only).

      Quaker Capital Management Corporation
      ------------------------------------------------------------

2.    Check the Appropriate Box if a Member of a Group 
      (a)
            -----
      (b)     X
            -----

3.    SEC Use Only
                     ---------------------------------------------

4.    Citizenship or Place of Organization                   Pennsylvania
                                                            ---------------

Number of         5.    Sole Voting Power                           892,500
Shares                                                      ---------------
Beneficially      6.    Shared Voting Power                       1,435,300
Owned by                                                    ---------------
Each Reporting    7.    Sole Dispositive Power                      892,500
Person With:                                                ---------------
                  8.    Shared Dispositive Power                  1,435,300
                                                            ---------------

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      2,327,800
      ---------

10.   Check if the Aggregate Amount in Row (9) Excludes Certain
      Shares
             --------

      The Reporting  Person disclaims  beneficial  ownership of 
      2,317,300 shares owned by its clients.

11.   Percent of Class Represented by Amount in Row (9)             10.53%
                                                            --------------

12.   Type of Reporting Person                                      IA
                                                            --------------



                               Page 2 of 4 Pages
<PAGE>
                                  SCHEDULE 13G
                               CUSIP NO. 576844104


      This  constitutes  Amendment  No. 1 to the Schedule 13G of Quaker  Capital
Management  Corporation  filed with the  Securities  and Exchange  Commission on
December  15,  1998  relating  to the  Common  Stock of  Matrix  Pharmaceutical,
Inc.(the "Schedule 13G").

Item 4 of the Schedule 13G is hereby amended and restated to read as follows:

Item 4.     Ownership
            ---------

      (a)   The Reporting Person, in its capacity as investment adviser,  may be
            deemed to be the beneficial  owner of 2,317,300 shares of the Common
            Stock of the Issuer which are owned by various  investment  advisory
            clients of the Reporting Person in accounts over which the Reporting
            Person has discretionary  authority. The filing of this report shall
            not be construed as an admission  that the Reporting  Person is, for
            purposes of Section 13(d) or 13(g) of the Act, the beneficial  owner
            of these securities.  Additionally,  the Reporting Person and/or its
            principals own 10,500 shares of the Common Stock of the Issuer.

      (b)   The shares  covered by this  report  represent  10.53% of the Common
            Stock of the Issuer.

      (c)   None of the  clients  of the  Reporting  Person is known to own more
            than 5% of the Common Stock of the Issuer.  The Reporting Person has
            shared voting and dispositive  power over 1,435,300  shares and sole
            voting  and  dispositive  power  over  882,000  shares  owned by its
            clients  and  held  in  accounts  over  which  it has  discretionary
            authority.  The  Reporting  Person and/or its  principals  have sole
            voting and  dispositive  power over the 10,500  shares  owned by the
            Reporting Person and/or its principals.

Item 6 of the Schedule 13G is hereby amended and restated to read as follows:

Item 6.     Ownership of More than Five Percent on
            Behalf of Another Person
            ---------------------------------------

            2,317,300  of the shares with  respect to which this report is filed
            are  owned  by a  variety  of  investment  advisory  clients  of the
            Reporting Person, which clients 


                               Page 3 of 4 Pages
<PAGE>
                                  SCHEDULE 13G
                               CUSIP NO. 576844104


            are entitled to receive  dividends on and the proceeds from the sale
            of such shares. No client is known to own more than 5% of the class.


                                    SIGNATURE

            After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.


                                          February 14, 1999
                                          ---------------------------------  
                                                        Date


                                          /s/ Mark G. Schoeppner, President
                                          ---------------------------------
                                                      Signature


                                          Mark G. Schoeppner, President
                                          --------------------------------- 
                                                    Name/Title




                               Page 4 of 4 Pages


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