MATRIX PHARMACEUTICAL INC/DE
8-K, EX-3.(I)-1, 2000-07-11
PHARMACEUTICAL PREPARATIONS
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                                                                 EXHIBIT 3(i).1


                                AMENDED AND RESTATED
                            CERTIFICATE OF INCORPORATION
                                         OF
                            MATRIX PHARMACEUTICAL, INC.
                               A DELAWARE CORPORATION

                      PURSUANT TO THE GENERAL CORPORATION LAW
                              OF THE STATE OF DELAWARE

              MATRIX PHARMACEUTICAL, INC., a corporation organized and existing
under the General Corporation Law of the State of Delaware, does hereby certify:

              FIRST:  The original Certificate of Incorporation of Matrix
Pharmaceutical, Inc. was filed with the Secretary of State of the State of
Delaware on December 16, 1991.

              SECOND:  The Amended and Restated Certificate of Incorporation, as
herein amended, and the Rights, Preferences and Restrictions of the Series B
Junior Participating Preferred Stock of the Corporation are hereby restated and
integrated into the single instrument which is hereinafter set forth, and which
is entitled Amended and Restated Certificate of Incorporation of Matrix
Pharmaceutical, Inc., without any further amendments other than the amendments
herein certified and without any discrepancy between the provisions of the
Amended and Restated Certificate of Incorporation, as herein amended, and the
Rights, Preferences and Restrictions of the Series B Junior Participating
Preferred Stock and the provisions of the said single instrument hereinafter set
forth.

              THIRD:  The amendment and the restatement of the Amended and
Restated Certificate of Incorporation set forth herein has been duly adopted in
accordance with the provisions of Sections 245, 242 and 211 of the General
Corporation Law of the State of Delaware by the directors and stockholders of
the Corporation.

              FOURTH:  The text of the Corporation's Amended and Restated
Certificate of Incorporation so adopted reads in full as set forth in EXHIBIT A
attached hereto and is hereby incorporated herein by this reference.

              IN WITNESS WHEREOF, Matrix Pharmaceutical, Inc. has caused this
Amended and Restated Certificate of Incorporation to be signed by the President
this 15th day of May, 2000.

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                                          MATRIX PHARMACEUTICAL, INC.

                                          By: /s/ Michael D. Casey
                                             ----------------------------------
                                                        Michael D. Casey
                                             CHAIRMAN, PRESIDENT AND CHIEF
                                             EXECUTIVE OFFICER












                                          2.

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                                     EXHIBIT A


                                AMENDED AND RESTATED


                            CERTIFICATE OF INCORPORATION

                                         OF

                            MATRIX PHARMACEUTICAL, INC.



                                     ARTICLE I

          The name of this corporation is Matrix Pharmaceutical, Inc.

                                      ARTICLE II

          The address of the registered office of the corporation in the
State of Delaware is 1209 Orange Street, in the City of Wilmington, County of
New Castle.  The name of its registered agent at such address is The Corporation
Trust Company.

                                     ARTICLE III

          The nature of the business or purposes to be conducted or promoted
is to engage in any lawful act or activity for which corporations may be
organized under the Delaware General Corporation Law.

                                      ARTICLE IV

          A.   CLASSES OF STOCK.  The corporation is authorized to issue
two classes of shares to be designated, respectively, "COMMON STOCK" and
"PREFERRED STOCK."  The total number of shares which the corporation is
authorized to issue is Sixty-One Million Nine Thousand One Hundred Twenty-Six
(61,009,126) shares.  Sixty Million (60,000,000) shares shall be Common Stock,
par value $0.01 per share and One Million Nine Thousand One Hundred Twenty-Six
(1,009,126) shares shall be Preferred Stock, par value $0.01 per share.

          B.   RIGHTS, PREFERENCES AND RESTRICTIONS OF PREFERRED.  The
Preferred Stock authorized by this Certificate of Incorporation may be issued
from time to time in series.  The rights, preferences, privileges, and
restrictions granted to and imposed on the Series B Junior Participating
Preferred Stock, which series shall consist of One Hundred Fifty Thousand
(150,000) shares, are as set forth in ANNEX A hereto, which is incorporated by
reference and made a part hereof.  The Board of Directors is hereby authorized
to fix or alter the rights, preferences, privileges and restrictions granted to
or imposed upon any series of Preferred Stock, and the number of shares
constituting any such series and the designation thereof, or of any of them.
Subject to compliance with applicable protective voting rights which have been
or may be granted to the Preferred Stock or series thereof in Certificates of
Designation or the corporation's



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Restated Certificate of Incorporation ("Protective Provisions"), but
notwithstanding any other rights of the Preferred or any series thereof, the
rights, privileges, preferences and restrictions of any such additional series
may be subordinated to, PARI PASSU with (including, without limitation,
including in provisions with respect to liquidation and acquisition preferences,
redemption and/or approval of matters by vote or written consent), or senior to
any of those of any present or future class or series of Preferred Stock or
Common Stock.  Subject to compliance with applicable Protective Provisions, the
Board of Directors is also authorized to increase or decrease the  number of
shares of any series prior or subsequent to the issue of that series, but not
below the number of shares of such series then outstanding.  In case the number
of shares of any series shall be so decreased, the shares constituting such
decrease shall resume the status which they had prior to the adoption of the
resolution originally fixing the number of shares of such series.

          C.   COMMON STOCK.

                (i) DIVIDEND RIGHTS.  Subject to the prior rights of
holders of all classes of stock at the time outstanding having prior rights as
to dividends, the holders of the Common shall be entitled to receive when and as
declared by the Board of Directors, out of any assets of the corporation legally
available therefor, such dividends as may be declared from time to time by the
Board of Directors.

               (ii) LIQUIDATION RIGHTS.  Subject to the prior rights of
holders of all classes of stock at the time outstanding having prior rights as
to liquidation, upon the liquidation, dissolution or winding up of the
corporation, the assets of the corporation shall be distributed to the holders
of the Common Stock.

               (iii)     REDEMPTION.  The Common is not redeemable as a
matter of right by any holder thereof.

               (iv) VOTING RIGHTS.  The holder of each share of Common
shall have the right to one vote, and shall be entitled to notice of any
stockholders' meeting in accordance with the Bylaws of the corporation, and
shall be entitled to vote upon such matters and in such manner as may be
provided by law.

                                      ARTICLE V

          Except as otherwise provided in this Certificate of Incorporation,
in furtherance and not in limitation of the powers conferred by statute, the
board of directors is expressly authorized to make, repeal, alter, amend and
rescind any or all of the bylaws of the corporation.

                                      ARTICLE VI

          The number of directors of the corporation shall be fixed from
time to time by, or in the manner provided in, the bylaws of the corporation or
amendment thereof duly adopted by the board of directors or by the stockholders
of the corporation.


                                          2.

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                                     ARTICLE VII

          Elections of directors need not be by written ballot unless the
bylaws of the corporation shall so provide.

                                     ARTICLE VIII

          Meetings of stockholders may be held within or without the State
of Delaware, as the bylaws of the corporation may provide.  The books of the
corporation may be kept (subject to any provision contained in the statutes)
outside the State of Delaware at such place or places as may be designated from
time to time by the board of directors or in the bylaws of the corporation.

                                      ARTICLE IX

          A director of the corporation shall not be personally  liable to
the corporation or its stockholders for monetary damages for breach of fiduciary
duty as a director, except for liability (i) for any breach of the director's
duty of loyalty to the corporation or its stockholders, (ii) for acts or
omissions not in good faith or which involve intentional misconduct or a knowing
violation of law, (iii) under Section 174 of the Delaware General Corporation
law, or (iv) for any transaction from which the director derived any improper
personal benefit.  If the Delaware General Corporation law is amended after
approval by the stockholders of this Article IX to authorize corporate action
further eliminating or limiting the personal liability of directors, then the
liability of a director of the corporation shall be eliminated or limited to the
fullest extent permitted by the Delaware General Corporation law as so amended.

          Any repeal or modification of the foregoing provisions of this
Article IX by the stockholders of the corporation shall not adversely affect any
right or protection of a director of the corporation existing at the time of
such repeal or modification.

                                      ARTICLE X

          To the fullest extent permitted by applicable law, this
corporation is also authorized to provide indemnification of (and advancement of
expenses to) such agents (and any other persons to which Delaware law permits
this corporation to provide indemnification) through bylaw provisions,
agreements with such agents or other persons, vote of stockholders or
disinterested directors or otherwise, in excess of the indemnification and
advancement otherwise permitted by Section 145 of the Delaware General
Corporation Law, subject only to limits created by applicable Delaware law
(statutory or non-statutory), with respect to actions for breach of duty to this
corporation, its stockholders, and others.

          Any repeal or modification of any of the foregoing provisions of
this Article XI shall not adversely affect any right or protection of a
director, officer, agent or other person existing at the time of, or increase
the liability of any director of this corporation with respect to


                                          3.
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any acts or omissions of such director, officer or agent occurring prior to such
repeal or modification.

                                      ARTICLE XI

          The corporation reserves the right to amend, alter, change or
repeal any provision contained in this Certificate of Incorporation, in the
manner now or hereafter prescribed by statute, and all rights conferred upon
stockholders herein are granted subject to this reservation.













                                          4.

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                                                                         ANNEX A


                        RIGHTS, PREFERENCES AND RESTRICTIONS
                                       OF THE
                   SERIES B JUNIOR PARTICIPATING PREFERRED STOCK




          The rights, preferences, restrictions and other matters relating
to the Series B Junior Participating Preferred Stock shall be as follows:

          Section 1.     DESIGNATION AND AMOUNT.  The shares of such series
shall be designated as "Series B Junior Participating Preferred Stock" (the
"Series B Preferred Stock") and the number of shares constituting the Series B
Preferred Stock shall be One Hundred Fifty Thousand (150,000).  Such number of
shares may be increased or decreased by resolution of the Board of Directors;
PROVIDED, that no decrease shall reduce the number of shares of Series B
Preferred Stock to a number less than the number of shares then outstanding plus
the number of shares reserved for issuance upon the exercise of outstanding
options, rights or warrants or upon the conversion of any outstanding securities
issued by the Corporation convertible into Series B Preferred Stock.

          Section 2.     DIVIDENDS AND DISTRIBUTIONS.

          (A)  Subject to the rights of the holders of any shares of any
series of Preferred Stock (or any similar stock) ranking prior and superior to
the Series B Preferred Stock with respect to dividends, the holders of shares of
Series B Preferred Stock, in preference to the holders of the Common Stock, par
value $.01 per share (the "Common Stock"), of the Corporation, and of any other
junior stock, shall be entitled to receive, when, as and if declared by the
Board of Directors out of funds legally available for the purpose, quarterly
dividends payable in cash on the first day of March, June, September and
December in each year (each such date being referred to herein as a "Quarterly
Dividend Payment Date"), commencing on the first Quarterly Dividend Payment Date
after the first issuance of a share or fraction of a share of Series B Preferred
Stock, in an amount per share (rounded to the nearest cent) equal to, subject to
the provision for adjustment hereinafter set forth, 100 times the aggregate per
share amount of all cash dividends, and 100 times the aggregate per share amount
(payable in kind) of all non-cash dividends or other distributions, other than a
dividend payable in shares of Common Stock or a subdivision of the outstanding
shares of Common Stock (by reclassification or otherwise), declared on the
Common Stock since the immediately preceding Quarterly Dividend Payment Date or,
with respect to the first Quarterly Dividend Payment Date, since the first
issuance of any share or fraction of a share of Series B Preferred Stock.  In
the event the Corporation shall at any time declare or pay any dividend on the
Common Stock payable in shares of Common Stock, or effect a subdivision or
combination or consolidation of the outstanding shares of Common Stock (by
reclassification or otherwise than by payment of a dividend in shares of Common
Stock) into a greater or lesser number of shares of Common Stock, then in each
such case the amount to which holders of shares of Series B Preferred Stock were
entitled immediately prior to such event under clause (b) of the preceding
sentence shall be adjusted by multiplying such amount by a fraction, the
numerator of which is the number of shares of Common Stock outstanding
immediately after such event and the denominator of which is the number of
shares of Common Stock that were outstanding immediately prior to such event.


                                         A-1
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          (B)  The Corporation shall declare a dividend or distribution on
the Series B Preferred Stock as provided in paragraph (A) of this Section
immediately after it declares a dividend or distribution on the Common Stock
(other than a dividend payable in shares of Common Stock).

          (C)  Dividends shall begin to accrue and be cumulative on
outstanding shares of Series B Preferred Stock from the Quarterly Dividend
Payment Date next preceding the date of issue of such shares, unless the date of
issue of such shares is prior to the record date for the first Quarterly
Dividend Payment Date, in which case dividends on such shares shall begin to
accrue from the date of issue of such shares, or unless the date of issue is a
Quarterly Dividend Payment Date or is a date after the record date for the
determination of holders of shares of Series B Preferred Stock entitled to
receive a quarterly dividend and before such Quarterly Dividend Payment Date, in
either of which events such dividends shall begin to accrue and be cumulative
from such Quarterly Dividend Payment Date.  Accrued but unpaid dividends shall
not bear interest.  Dividends paid on the shares of Series B Preferred Stock in
an amount less than the total amount of such dividends at the time accrued and
payable on such shares shall be allocated pro rata on a share-by-share basis
among all such shares at the time outstanding.  The Board of Directors may fix a
record date for the determination of holders of shares of Series B Preferred
Stock entitled to receive payment of a dividend or distribution declared
thereon, which record date shall be not more than 60 days prior to the date
fixed for the payment thereof.

          Section 3.     VOTING RIGHTS.  The holders of shares of Series B
Preferred Stock shall have the following voting rights:

          (A)  Subject to the provision for adjustment hereinafter set
forth, each share of Series B Preferred Stock shall entitle the holder thereof
to 100 votes on all matters submitted to a vote of the stockholders of the
Corporation.  In the event the Corporation shall at any time declare or pay any
dividend on the Common Stock payable in shares of Common Stock, or effect a
subdivision or combination or consolidation of the outstanding shares of Common
Stock (by reclassification or otherwise than by payment of a dividend in shares
of Common Stock) into a greater or lesser number of shares of Common Stock, then
in each such case the number of votes per share to which holders of shares of
Series B Preferred Stock were entitled immediately prior to such event shall be
adjusted by multiplying such number by a fraction, the numerator of which is the
number of shares of Common Stock outstanding immediately after such event and
the denominator of which is the number of shares of Common Stock that were
outstanding immediately prior to such event.

          (B)  Except as otherwise provided herein, in any other
Certificate of Designations creating a series of Preferred Stock or any similar
stock, or by law, the holders of shares of Series B Preferred Stock and the
holders of shares of Common Stock and any other capital stock of the Corporation
having general voting rights shall vote together as one class on all matters
submitted to a vote of stockholders of the Corporation.

          (C)  Except as set forth herein, or as otherwise provided by
law, holders of Series B Preferred Stock shall have no special voting rights and
their consent shall not be required (except to the extent they are entitled to
vote with holders of Common Stock as set forth herein) for taking any corporate
action.


                                         A-2
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          Section 4.     CERTAIN RESTRICTIONS.

          (A)  Whenever quarterly dividends or other dividends or
distributions payable on the Series B Preferred Stock as provided in Section 2
are in arrears, thereafter and until all accrued and unpaid dividends and
distributions, whether or not declared, on shares of Series B Preferred Stock
outstanding shall have been paid in full, the Corporation shall not:

               (i)  declare or pay dividends, or make any other
distributions, on any shares of stock ranking junior (either as to dividends or
upon liquidation, dissolution or winding up) to the Series B Preferred Stock;

               (ii) declare or pay dividends, or make any other
distributions, on any shares of stock ranking on a parity (either as to
dividends or upon liquidation, dissolution or winding up) with the Series B
Preferred Stock, except dividends paid ratably on the Series B Preferred Stock
and all such parity stock on which dividends are payable or in arrears in
proportion to the total amounts to which the holders of all such shares are then
entitled;

               (iii)     redeem or purchase or otherwise acquire for
consideration shares of any stock ranking junior (either as to dividends or upon
liquidation, dissolution or winding up) to the Series B Preferred Stock,
provided that the Corporation may at any time redeem, purchase or otherwise
acquire shares of any such junior stock in exchange for shares of any stock of
the Corporation ranking junior (either as to dividends or upon dissolution,
liquidation or winding up) to the Series B Preferred Stock; or

               (iv) redeem or purchase or otherwise acquire for
consideration any shares of Series B Preferred Stock, or any shares of stock
ranking on a parity with the Series B Preferred Stock, except in accordance with
a purchase offer made in writing or by publication (as determined by the Board
of Directors) to all holders of such shares upon such terms as the Board of
Directors, after consideration of the respective annual dividend rates and other
relative rights and preferences of the respective series and classes, shall
determine in good faith will result in fair and equitable treatment among the
respective series or classes.

          (B)  The Corporation shall not permit any subsidiary of the
Corporation to purchase or otherwise acquire for consideration any shares of
stock of the Corporation unless the Corporation could, under paragraph (A) of
this Section 4, purchase or otherwise acquire such shares at such time and in
such manner.

          Section 5.     REACQUIRED SHARES.  Any shares of Series B Preferred
Stock purchased or otherwise acquired by the Corporation in any manner
whatsoever shall be retired and cancelled promptly after the acquisition
thereof.  All such shares shall upon their cancellation become authorized but
unissued shares of Preferred Stock and may be reissued as part of a new series
of Preferred Stock subject to the conditions and restrictions on issuance set
forth herein, in the Certificate of Incorporation, or in any other Certificate
of Designations creating a series of Preferred Stock or any similar stock or as
otherwise required by law.

          Section 6.     LIQUIDATION, DISSOLUTION OR WINDING UP.  Upon any
liquidation, dissolution or winding up of the Corporation, no distribution shall
be made (1) to the holders of shares of stock ranking junior (either as to
dividends or upon liquidation, dissolution or winding



                                         A-3
<PAGE>

up) to the Series B Preferred Stock unless, prior thereto, the holders of shares
of Series B Preferred Stock shall have received $100 per share, plus an amount
equal to accrued and unpaid dividends and distributions thereon, whether or not
declared, to the date of such payment, provided that the holders of shares of
Series B Preferred Stock shall be entitled to receive an aggregate amount per
share, subject to the provision for adjustment hereinafter set forth, equal to
100 times the aggregate amount to be distributed per share to holders of shares
of Common Stock, or (2) to the holders of shares of stock ranking on a parity
(either as to dividends or upon liquidation, dissolution or winding up) with the
Series B Preferred Stock, except distributions made ratably on the Series B
Preferred Stock and all such parity stock in proportion to the total amounts to
which the holders of all such shares are entitled upon such liquidation,
dissolution or winding up.  In the event the Corporation shall at any time
declare or pay any dividend on the Common Stock payable in shares of Common
Stock, or effect a subdivision or combination or consolidation of the
outstanding shares of Common Stock (by reclassification or otherwise than by
payment of a dividend in shares of Common Stock) into a greater or lesser number
of shares of Common Stock, then in each such case the aggregate amount to which
holders of shares of Series B Preferred Stock were entitled immediately prior to
such event under the proviso in clause (1) of the preceding sentence shall be
adjusted by multiplying such amount by a fraction the numerator of which is the
number of shares of Common Stock outstanding immediately after such event and
the denominator of which is the number of shares of Common Stock that were
outstanding immediately prior to such event.

          Section 7.     CONSOLIDATION, MERGER, ETC.  In case the Corporation
shall enter into any consolidation, merger, combination or other transaction in
which the shares of Common Stock are exchanged for or changed into other stock
or securities, cash and/or any other property, then in any such case each share
of Series B Preferred Stock shall at the same time be similarly exchanged or
changed into an amount per share, subject to the provision for adjustment
hereinafter set forth, equal to 100 times the aggregate amount of stock,
securities, cash and/or any other property (payable in kind), as the case may
be, into which or for which each share of Common Stock is changed or exchanged.
In the event the Corporation shall at any time declare or pay any dividend on
the Common Stock payable in shares of Common Stock, or effect a subdivision or
combination or consolidation of the outstanding shares of Common Stock (by
reclassification or otherwise than by payment of a dividend in shares of Common
Stock) into a greater or lesser number of shares of Common Stock, then in each
such case the amount set forth in the preceding sentence with respect to the
exchange or change of shares of Series B Preferred Stock shall be adjusted by
multiplying such amount by a fraction, the numerator of which is the number of
shares of Common Stock outstanding immediately after such event and the
denominator of which is the number of shares of Common Stock that were
outstanding immediately prior to such event.

          Section 8.     NO REDEMPTION.  The shares of Series B Preferred
Stock shall not be redeemable.

          Section 9.     RANK.  The Series B Preferred Stock shall rank, with
respect to the payment of dividends and the distribution of assets, junior to
all series of any other class of the Corporation's Preferred Stock.


                                         A-4
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          Section 10.    AMENDMENT.  The Certificate of Incorporation of the
Corporation shall not be amended in any manner which would materially alter or
change the powers, preferences or special rights of the Series B Preferred Stock
so as to affect them adversely without the affirmative vote of the holders of at
least a majority of the outstanding shares of Series B Preferred Stock, voting
together as a single class.
















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