PARACELSIAN INC /DE/
S-3/A, 1999-04-05
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                          AS FILED WITH THE SECURITIES
                    AND EXCHANGE COMMISSION ON MARCH __, 1999
                           REGISTRATION NO. 333-71257

- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                 -------------
                     PRE-EFFECTIVE AMENDMENT NUMBER ONE TO
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                                PARACELSIAN, INC.
             (Exact name of Registrant as Specified in Its Charter)

             DELAWARE                                   56-1399565
    (State of Other Jurisdiction                     (I.R.S. Employer
     of Incorporation or Organization)               Identification No.)

                            222 Langmuir Laboratories
                             Cornell Technology Park
                             Ithaca, New York 14850
                                 (607) 257-4224
        (Address, Including Zip Code and Telephone, Including Area Code,
                  of Registrant's Principal Executive Offices)

                                 Bernard Landes
                            222 Langmuir Laboratories
                             Cornell Technology Park
                             Ithaca, New York 14850
                                 (607) 257-4224
        (Address, Including Zip Code and Telephone, Including Area Code,
                  of Registrant's Principal Executive Offices)
                                   Copies to:
                             Ronald D. Raxter, Esq.
                      The Sanford Holshouser Law Firm, PLLC
                             219 Fayetteville Street
                                   Suite 1000
                          Raleigh, North Carolina 27601

         APPROXIMATE  DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:  From
time to time after the effective date of this Registration Statement.

<PAGE>

         If the only securities  being registered on this Form are being offered
pursuant to dividend or interest  reinvestment plans, please check the following
box. [ ]

         If any of the  securities  being  registered  on  this  Form  are to be
offered  on a  delayed  or  continuous  basis  pursuant  to Rule 415  under  the
Securities Act of 1933,  other than  securities  offered only in connection with
dividend or interest reinvestment plans, check the following box. [X]

         If this Form is filed to register additional securities for an offering
pursuant to Rule 462 (b) under the  Securities  Act,  please check the following
box and list the Securities  Act  registration  statement  number of the earlier
effective registration statement for the same offering. [ ]

         If this Form is a  post-effective  amendment filed pursuant to Rule 462
(c) under the  Securities  Act,  check the following box and list the Securities
Act  registration   statement  number  of  the  earlier  effective  registration
statement for the same offering. [ ]

         If delivery of the  prospectus  is expected to be made pursuant to Rule
434, please check the following box. [ ]

                         CALCULATION OF REGISTRATION FEE
- --------------------------------------------------------------------------------

TO BE REGISTERED          REGISTERED      PER SHARE (1)     PROPOSED      FEE
                                          OFFERING PRICE    MAXIMUM

   
Common Stock,             7,316,180 (2)   $0.88             $6,438,238   $1,790
$0.01 par value per share
    

(1)      Estimated  solely  for the  purpose  of  computing  the  amount  of the
         registration  fee in accordance  with Rule 457 (c) under the Securities
         Act of 1933.

(2)      This  Registration  Statement shall also cover any additional shares of
         Common  Stock  which  become  issuable  in  connection  with the shares
         registered  for sale  hereby as a result of any stock  dividend,  stock
         split,  recapitalization or other similar transaction  effected without
         the receipt of consideration which results in an increase in the number
         of the Registrant's outstanding shares of Common Stock.

THE REGISTRANT HEREBY AMENDS THIS  REGISTRATION  STATEMENT ON SUCH DATE OR DATES
AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT  SHALL FILE
A FURTHER  AMENDMENT THAT SPECIFICALLY  STATES THAT THIS REGISTRATION  STATEMENT
SHALL  THEREAFTER  BECOME  EFFECTIVE  IN  ACCORDANCE  WITH  SECTION 8 (a) OF THE
SECURITIES  ACT OF  1933  OR  UNTIL  THE  REGISTRATION  STATEMENT  SHALL  BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8 (a),
MAY DETERMINE.

<PAGE>
   

                             SUBJECT TO COMPLETION

PROSPECTUS
- ----------

                                7,316,180 SHARES


                                PARACELSIAN, INC.
                                  COMMON STOCK

         This document  registers  shares of common stock of  Paracelsian,  Inc.
         which are owned by the selling  stockholders listed in this Prospectus.
         The shares  were sold to the selling  stockholders  by  Paracelsian  in
         January and December 1998 under  exemptions  from the securities  laws.
         Paracelsian  will not receive any proceeds  from the sale of the shares
         registered in this Prospectus.


         After  registration,  the shares of common stock will be available  for
         sale on the NASD Bulletin Board under the symbol "PRLN" where the other
         registered shares of Paracelsian are listed.


         INVESTING IN THE COMMON STOCK INVOLVES A HIGH DEGREE OF RISK. SEE "RISK
         FACTORS" BEGINNING ON PAGE 2.


                                                   Per Share        Total
                                                   ---------        -----
         Public Offering Price
         Underwriting Discounts and Commissions      -0-             -0-
         Proceeds to the Selling Shareholders


         NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
         COMMISSION HAS APPROVED OR DISAPPROVED  THESE  SECURITIES OR DETERMINED
         IF THIS PROSPECTUS IS TRUTHFUL OR COMPLETE.  ANY  REPRESENTATION TO THE
         CONTRARY IS A CRIMINAL OFFENSE.



                                   ----------

                  The date of this Prospectus is _______, 1999.
    
<PAGE>

                 RISK FACTORS RELATING TO PURCHASE OF THE SHARES

         IN ADDITION  TO THE OTHER  INFORMATION  CONTAINED  OR  INCORPORATED  BY
REFERENCE  IN  THIS  PROSPECTUS,  PROSPECTIVE  PURCHASERS  SHOULD  CONSIDER  THE
FOLLOWING FACTORS CAREFULLY IN EVALUATING PARACELSIAN AND ITS BUSINESS. SEE ALSO
"SPECIAL NOTE REGARDING FORWARD LOOKING STATEMENTS."

   
PARACELSIAN IS ATTEMPTING TO DEVELOP A NEW TECHNOLOGY WITH NEW MANAGEMENT AND A
REVISED BUSINESS PLAN WHICH MAY NOT BE SUCCESSFUL

         Although Paracelsian  commenced operations in April 1991, it has yet to
generate  significant  revenues.  Paracelsian  has  been  engaged  primarily  in
research,  product engineering and raising capital. In January 1998, Paracelsian
acquired  an entirely  new Board of  Directors  and  executive  management.  New
management has substantially  altered the business plan for Paracelsian with the
aim  of   generating   operating   revenues.   Revenues  for  fiscal  1998  were
approximately $56,000 which resulted primarily from contract laboratory services
and the sale of biological test kits developed by  Paracelsian.  Future revenues
will be derived from sales of  Paracelsian's  services that are currently  under
development and royalties in connection with licensing of its technology.  There
can be no assurance  that  Paracelsian  will be able to attain such  revenues in
sufficient  amounts to achieve profitable  operations.  Results of operations in
the future will be  influenced  by numerous  factors,  including  the ability of
Paracelsian to develop and manage the  introduction of its new services,  market
acceptance of  Paracelsian's  services,  competition  and the ability to control
costs.

PARACELSIAN  HAS LIMITED  LIQUIDITY AND CAPITAL  RESOURCES WHICH MAY CURTAIL ITS
OPERATIONS

         As of December  31, 1998,  Paracelsian  maintained  working  capital of
$131,000  which  included  cash of  approximately  $189,000.  In December  1998,
Paracelsian  raised  $250,000  through a private  placement  of its stock and in
March 1999,  Paracelsian raised an additional $150,000 in cash through a private
placement  of its  stock.  The  cost  of  Paracelsian's  current  operations  is
approximately  $90,000  per month.  Failure to continue  to  successfully  raise
additional capital to support its continued operations may curtail Paracelsian's
ability  to  implement  its  business  plan  to  generate  operating   revenues.
Paracelsian presently intends to pursue additional capital of $1 million to $1.5
million in the near term, if available on reasonable terms, to provide resources
for the hiring of  additional  personnel,  expansion  and/or  relocation  of lab
facilities,  and the  acceleration of product  development  efforts.  Of course,
there  can be no  assurance  that  additional  financing  will be  available  on
acceptable  terms or at all. If adequate  funds are not available from operating
revenues  or sources of  financing,  Paracelsian's  operations  would have to be
curtailed.

PARACELSIAN'S  CURRENT  BUSINESS  PLAN IS  DEPENDENT  ON A KEY  DISTRIBUTOR  AND
FAILURE OF THAT  RELATIONSHIP WILL  SIGNIFICANTLY  REDUCE THE PROSPECT OF FUTURE
REVENUES

         Paracelsian's initial revenues are highly dependent upon the ability to
market the BioFITTM  designation  in the herbal and dietary  supplement  market.
BioFITTM  designation  confirms that the herbal and dietary  supplement  product
shows biological  activities consistent with the benefit claims on the product's
label.  Paracelsian has entered into an agreement with a leading manufacturer of
herbal and other dietary supplement products to serve as Paracelsian's exclusive
agent for the marketing and distribution of its BioFITTM  Certification Program.
Paracelsian  is relying on this company for the  successful and timely launch of
its  BioFITTM  program  and the receipt of  operating  revenues  from  BioFITTM.
Failure to launch  BioFITTM in a timely  manner or failure to secure an adequate
number of customers would materially reduce anticipated operating revenues.

PARACELSIAN DOES NOT CURRENTLY HAVE A COMPLETE  MANAGEMENT TEAM WHICH LIMITS ITS
ABILITY TO IMPLEMENT ITS NEW BUSINESS PLAN

         Key positions not yet filled  include Chief  Financial  Officer,  Chief
Operations Officer, Vice President of
    
                                      -2-

<PAGE>

   

Science, and Vice President of Business Development.  Presently, these functions
are performed by Bernard Landes, Ph.D.,  Paracelsian's  Chairman,  President and
Chief Executive Officer,  assisted by certain members of Paracelsian's  Board of
Directors.  Paracelsian's  ability to implement  its business plan is limited by
the lack of a complete full-time management team.

PARACELSIAN'S  OPERATIONS  ARE  DEPENDENT ON KEY  PERSONNEL TO IMPLEMENT ITS NEW
BUSINESS PLAN

         The loss of the services of Mr.  Landes  could have a material  adverse
effect on Paracelsian.  In addition,  Paracelsian's  performance  depends on its
ability to attract and retain qualified management and professional,  scientific
and  technical  operating  staff,  as well as its  ability to recruit  qualified
representatives for its contract sales services.  There can be no assurance that
Paracelsian will be able to continue to attract and retain qualified  personnel.
Lack of qualified  personnel will limit  Paracelsian's  ability to implement its
business plan.

THE  BUSINESS  PLAN IS BASED ON  PROPRIETARY  TECHNOLOGY  AND ITS SUCCESS MAY BE
LIMITED BY THE UNPREDICTABILITY OF PATENT PROTECTION

         Certain of the  technologies  utilized in  Paracelsian's  products  are
proprietary.  Paracelsian  believes  that  patent  protection  of  materials  or
processes  it  develops  and any  products  that may result  from  Paracelsian's
research and development efforts are important to the possible commercialization
of  Paracelsian's  products.  Paracelsian  currently  has US  patent  protection
regarding  various uses of its assays.  Its  Ah-IMMUNOASSAY  technology has been
approved  for use in the  detection of dioxins.  It has also been  approved as a
novel method of identifying  compounds  that might be effective  against HIV and
other viral infections.  Paracelsian's  CDK1 Assay has been approved to quantify
cancer causing activity of test substances, even those that have been previously
thought to be non-genotoxic and /or non-mutagenic. Paracelsian's scientists have
been using the CDK1 Assay to test the TCM library for cancer  treatments.  While
Paracelsian is actively  seeking  partners to fully develop the market potential
of these  patents,  there can be no assurance  that  Paracelsian's  patents will
afford adequate protection to Paracelsian or its licensees.  Further,  there can
be no  assurance  that any patents  that have been or may be issued will provide
Paracelsian  with  significant  protection from  competitors.  Other private and
public entities may file applications for patents and other  proprietary  rights
to technology which could be harmful to the  commercialization  of Paracelsian's
services and products.  The ultimate scope and validity of patents which are now
owned by or which may be granted to third  parties in the future,  the extent to
which  Paracelsian may wish or be required to acquire rights under such patents,
and the cost or  availability of such rights cannot be determined by Paracelsian
at this time. In addition,  Paracelsian  also relies on  unpatented  proprietary
technology  in  the  development  and  commercialization  of  its  services  and
products.  There is no assurance that others may not  independently  develop the
same or  similar  technology  or  obtain  access  to  Paracelsian's  proprietary
technology or disclose  such  technology or that  Paracelsian  can  meaningfully
protect its rights in such unpatented proprietary technology.

THE  DIRECTORS  AND  EXECUTIVE  OFFICER  OF  PARACELSIAN  HAVE THE POWER TO TAKE
ACTIONS THAT MAY NOT BE IN THE BEST INTERESTS OF OTHER SHAREHOLDERS

         The directors and executive officer of Paracelsian  beneficially own or
have voting  control over  7,153,477  shares of Common Stock,  or  approximately
38.07% of  Paracelsian's  outstanding  shares of Common Stock as of December 22,
1998.  Such  directors  and  executive  officers are  therefore in a position to
significantly influence the election of Paracelsian's directors.  Subject to its
fiduciary  duties under  Delaware  law, the board of directors  has the power to
select  management and direct the business and affairs of  Paracelsian.  Certain
shareholders may not believe that such policies are in their best interests.

THE LIMITED TRADING MARKET FOR THE COMMON STOCK MAY REDUCE THE STOCK PRICE

         The common stock is currently  traded on the NASD  Bulletin  Board (the
electronic pink sheets) under the

    
                                      -3-

<PAGE>

   

symbol  "PRLN." There are only a limited number of trades of the common stock on
this  market.  Due to the limited  trading  market for the common  stock,  it is
possible  that  holders of the common  stock will be not be able to resell their
shares in the  future  for a price  per share  that is equal to or more than the
current price of the common stock.

THE PENNY STOCK RULES FURTHER REDUCE TRADING OF THE COMMON STOCK

         The Securities  Enforcement and Penny Stock Reform Act of 1990 requires
brokers to give additional  disclosures  regarding stocks meeting the definition
of a penny stock.  Paracelsian's  common stock  currently  would be defined as a
penny stock.  These additional  disclosure  requirements may cause brokers to be
unwilling to engage in  transactions in  Paracelsian's  common stock and thereby
reduce trading  activity.  This may make it more difficult for  shareholders  to
sell their common stock.

THE STOCK PRICE OF THE COMMON STOCK IS SUBJECT TO WIDE FLUCTUATIONS

         The market  price of the common  stock has been and may  continue to be
subject to wide fluctuations in response to variations in operating results from
quarter to quarter,  market  conditions  in the  industry  and general  economic
conditions.  During the period from February 1998 to February  1999,  the common
stock has ranged in price from a low of $0.18 to a high of $2.00.  The price per
share of the common stock when a shareholder wishes to sell the common stock may
be less than the purchase price.

ANY RETURN ON AN INVESTMENT IN THE COMMON STOCK MUST BE FROM PRICE APPRECIATION
SINCE PARACELSIAN IS UNLIKELY TO PAY CASH DIVIDENDS

         Paracelsian has not paid any cash dividends. It is unlikely Paracelsian
will pay any cash dividends in the foreseeable future. Earnings, if any, will be
retained by Paracelsian  for further  development and expansion of its business.
Any return on an  investment in the shares is dependent on  appreciation  in the
stock price.

                       WHERE YOU CAN FIND MORE INFORMATION

         Paracelsian  files  annual,   quarterly  and  special  reports,   proxy
statements and other  information  with the  Securities and Exchange  Commission
(the SEC). You may read and copy any reports, statements or other information we
file at the SEC's public reference rooms in Washington, D.C., New York, New York
and  Chicago,  Illinois.  Please  call  the SEC at  1-800-SEC-0330  for  further
information on the public reference rooms. Our SEC filings are also available to
the public from commercial document retrieval services and at the Internet world
wide web site maintained by the SEC at

         As allowed by SEC  rules,  this  prospectus  does not  contain  all the
information  you can find in the  Registration  Statement or the exhibits to the
Registration Statement.

         The SEC allows us to "incorporate by reference"  information  into this
prospectus,  which means that we can disclose  important  information  to you by
referring you to another document filed separately with the SEC. The information
incorporated  by reference is deemed to be part of this  prospectus,  except for
any information superseded by information contained directly in this prospectus.
This prospectus  incorporates by reference the documents set forth below that we
have  previously  filed  with  the  SEC.  These  documents   contain   important
information about our companies and their financial condition.

         Annual  Report on Form 10-K         Year ended  September  30,  1998
         Quarterly Report on Form 10-Q       Quarter ended December 31, 1998

         Paracelsian  also   incorporates  by  reference  into  this  prospectus
additional documents that may be filed

    
                                      -4-

<PAGE>

   

with the SEC after the date of this prospectus.  These include periodic reports,
such as Annual Reports on Form 10-K,  Quarterly Reports on Form 10-Q and Current
Reports on Form 8-K, as well as proxy statements.

         If you are a  shareholder,  we may have sent you some of the  documents
incorporated by reference, but you can obtain any of them through us, the SEC or
the  SEC's  Internet  world  wide  web  site  as  described   above.   Documents
incorporated  by reference are available from us without  charge,  excluding all
exhibits  unless we have  specifically  incorporated  by reference an exhibit in
this  prospectus  by  requesting  them  in  writing  or by  telephone  from  the
appropriate company at the following addresses:

              Paracelsian, Inc.
              222 Langmuir Laboratories, Cornell Technology Park
              Ithaca, New York 14850
              Attention: Corporate Secretary
              Telephone:  (607)257-4224

         YOU SHOULD RELY ONLY ON THE  INFORMATION  CONTAINED OR  INCORPORATED BY
REFERENCE IN THIS PROSPECTUS.  WE HAVE NOT AUTHORIZED ANYONE TO PROVIDE YOU WITH
INFORMATION  THAT IS DIFFERENT FROM WHAT IS CONTAINED IN THIS  PROSPECTUS.  THIS
PROSPECTUS IS DATED MARCH __, 1999.  YOU SHOULD NOT ASSUME THAT THE  INFORMATION
CONTAINED  IN THE  PROSPECTUS  IS  ACCURATE AS OF ANY DATE OTHER THAN THAT DATE.
NEITHER THE  DELIVERY OF THIS  PROSPECTUS  NOR THE SALE OF ANY COMMON STOCK WITH
THIS PROSPECTUS SHALL CREATE ANY IMPLICATION TO THE CONTRARY.

         THIS PROSPECTUS DOES NOT CONSTITUTE AN OFFER TO SELL, OR A SOLICITATION
OF AN OFFER TO BUY,  BY ANY PERSON IN ANY  JURISDICTION  IN WHICH IT IS UNLAWFUL
FOR SUCH PERSON TO MAKE SUCH OFFER OR SOLICITATION.

                SPECIAL NOTE REGARDING FORWARD LOOKING STATEMENTS
    

         This  prospectus  contains,  in  addition  to  historical  information,
various  "forward  looking   statements"  within  the  meaning  of  the  Private
Securities  Litigation  Reform Act of 1995.  These  forward  looking  statements
represent  Paracelsian's judgment concerning the future and are subject to risks
and uncertainties  that could cause  Paracelsian's  actual operating results and
financial  position to differ  materially  from those  projected  in the forward
looking  statements.  Such forward looking statements are necessarily  estimates
reflecting the best judgment of the senior management of Paracelsian. Statements
in this prospectus that are not historical facts are forward looking  statements
for the purpose of the safe harbor  provided by Section 21E of the  Exchange Act
and Section 27A of the Securities Act.

         Terms such as "may,"  "will,"  "expect,"  "anticipate,"  "estimate," or
"continue" or other  variations of these terms are intended to identify  forward
looking  statements.   Paracelsian   cautions  that  any  such  forward  looking
statements  are  further   qualified  by  important  factors  that  could  cause
Paracelsian's   actual  operating  results  and  financial  position  to  differ
materially from the forward looking  statements,  including  without  limitation
considerations described in connection with specific forward looking statements,
factors set forth in this prospectus under the caption "Risk Factors," and other
cautionary statements set forth in this prospectus. Readers are cautioned not to
place undue reliance on these forward looking statements, which speak only as of
the date of this  prospectus.  Paracelsian  undertakes  no obligation to release
publicly the results of any  revisions to these  forward  looking  statements to
reflect events or circumstances  arising after the date of this prospectus or to
reflect the occurrence of unanticipated events.

   

         PARACELSIAN

         Paracelsian is a development  stage drug discovery and research service
company that uses its proprietary screening technology to measure the effects of
natural compounds on cell division. This research enables

    
                                      -5-

<PAGE>

   

Paracelsian  to provide a sound  scientific  understanding  of the bases for the
beneficial  effects of herbal medicines and dietary  supplements.  Paracelsian's
management has focused its primary activities in three (3) areas:

         (1) Quality  Assurance  Designation.  Paracelsian  uses its proprietary
         technology to evaluate herbal and dietary supplement  products based on
         how they perform in a  scientifically  selected  battery of  functional
         tests.  If they  demonstrate  activity  within  the proper  range,  the
         product  is  certified  as  BioFIT,   or  "Bio   Functional   Integrity
         Tested,"Paracelsian's trademarked designation.  Paracelsian has entered
         into an  agreement  with a leading  manufacturer  of  herbal  and other
         dietary  supplement  products to serve as its  exclusive  agent for the
         marketing  and  distribution  of  its  BioFIT  Certification   Program.
         Paracelsian  has begun to receive  certain  payments  pursuant  to this
         agreement.

         (2) Product  Discovery and  Development.  Paracelsian is  investigating
         several  potential  therapeutic  compounds from its extract  library of
         approximately  2,764  Traditional  Chinese  Medicines  and other  plant
         materials  to target  drug  candidates.  If the  tests are  successful,
         Paracelsian  will pursue the  marketing of these  compounds  indirectly
         through manufacturers. Paracelsian also believes that it may be able to
         identify potential  collaborative partners to use the BioFIT process to
         investigate "target" compounds of various materials.

         (3) Environmental  Screening and Drug Development.  Paracelsian has two
         patented   bioassays:   the   Ah-Immunoassay   and  CDK1   Assay.   The
         Ah-Immunoassay detects potentially toxic dioxins in the environment and
         provides   quick,   accurate  and  inexpensive   results   compared  to
         traditional  analytical  techniques.  Paracelsian  has entered  into an
         agreement with a Japanese industry to test commercial  incinerators for
         dioxin  levels.  Paracelsian  has  begun to  receive  certain  payments
         pursuant to this agreement.  The  Ah-Immunoassay has also been received
         patent  approval as a novel method of identifying  compounds that might
         be  effective  against HIV and other viral  infections.  The CDK1 Assay
         detects  non-geotoxic  carcinogens  and measures the  concentration  of
         Cyclin Dependent Kinase 1 ("CDK1"), a key cell division control enzyme.
         Compounds that inhibit CDK1 may be capable of inhibiting cell growth in
         proliferative  based disorders such as cancer.  This assay would enable
         researchers to screen out  carcinogenic  drug candidates  before animal
         carcinogenicity   trials  are   conducted,   potentially   saving  drug
         researchers significant costs.

         Paracelsian  has operated at a loss since its formation in 1991.  There
can be no assurance that  Paracelsian will ever achieve  profitable  operations.
See "Risk Factors."

         Paracelsian  was  incorporated  in  Delaware  in  1991.  Its  principal
executive offices are located at 222 Langmuir  Laboratories,  Cornell Technology
Park,  Ithaca,  New York 14850 and its telephone  number is (607) 257-4224.  Its
common stock is quoted on the NASD  Bulletin  Board under the symbol  "PRLN." On
March __, 1999, the last reported sale price of the common stock was $______ per
share. Paracelsian and BioFIT are trademarks of Paracelsian.
    

                                 USE OF PROCEEDS

         The shares being registered in this prospectus are owned by the selling
stockholders.  Paracelsian  is not  selling  any shares and will not receive any
proceeds from the sale of any of the shares. See "Plan of Distribution."

                              SELLING STOCKHOLDERS

         The selling stockholders purchased the shares directly from Paracelsian
in private sales under certain exemptions from the securities law. The following
table  sets forth  certain  information  regarding  the stock  ownership  of the
selling stockholders as of the date of this prospectus.  All of the shares being
registered by the

                                      -6-

<PAGE>

   
selling  stockholders  may be sold pursuant to this  prospectus.  The shares are
being  registered to permit the selling  shareholders  to sell the shares to the
public from time to time. See "Plan of Distribution."  The percentage  ownership
is based on the  18,690,253  shares  of  common  stock  which  were  issued  and
outstanding as of December 22, 1998.
    
<TABLE>
<CAPTION>

                                 Shares                 Shares      Shares Beneficially
                                 Beneficially Owned     Being       Owned After Sale of
                                 Prior to Registration  Registered  All Registered Shares
                                 ---------------------  ----------  ---------------------
                                  Number    Percent                 Number    Percent
                                  ------    -------                 ------    -------
<S>                              <C>         <C>       <C>              <C>       <C>
Biomar International, Inc. (1)   6,025,575   32.24     6,025,575       -0-       -0-
John A. Williams                   758,666    4.06       666,666      92,000      *
Bernard Landes                     203,000    1.09       100,000     103,000      *
C. David Smith                     100,000     *         100,000       -0-       -0-
Thomas D. Livingston               208,095    1.11       200,000       8,095      *
Thomas H. Evans                     50,000     *          50,000       -0-       -0-
Sylvestor Johnson IV               117,283     *         117,283       -0-       -0-
   
Stephen Holt, MD                     6,656     *           6,656       -0-       -0-
     
G.W. Thorpe                         50,000     *          50,000       -0-       -0-
</TABLE>

- ----------

         *  Denotes beneficial ownership of less than one percent of the Shares.
   
         (1) Effective  February 1999,  Biomar  International,  Inc. changed its
         corporate name to BioSignia, Inc.
    
                              PLAN OF DISTRIBUTION

         The shares  registered in this  prospectus by the selling  stockholders
may be sold at any time after the effective date of the prospectus. The decision
to offer and sell the  shares  and the  timing and amount of any offers or sales
that are made, is within the sole  discretion of the selling  stockholders.  The
shares may be sold by one or more of the following methods, without limitation:

   

         (a) a block trade in which the  broker-dealer  will attempt to sell the
         shares as agent but may  position  and resell a portion of the block as
         principal to facilitate the transaction;

         (b)  purchases  by a broker or dealer as  principal  and resale by such
         broker or dealer for its account pursuant to this prospectus;

         (c)  ordinary  brokerage  transactions  and  transactions  in which the
         broker solicits purchasers; and

         (d) privately negotiated  transactions between the selling stockholders
         and purchasers without a broker-dealer.

         In addition, any securities covered by this prospectus that qualify for
sale pursuant to Rule 144 under the Securities Act might be sold under Rule 144
rather than pursuant to this prospectus.
    

         In making sales, brokers or dealers engaged by the selling stockholders
may arrange for other brokers or dealers to participate. Such brokers or dealers
may receive commissions or discounts from the selling

                                      -7-

<PAGE>

stockholders.  The selling stockholders and the brokers and dealers through whom
sales of the  shares may be made may be deemed to be  "underwriters"  within the
meaning of the  Securities  Act, and their  commissions  or discounts  and other
compensation may be regarded as underwriters' compensation.

         Paracelsian  anticipates that the Registration  Statement of which this
prospectus is a part shall remain  effective  until the date on which all of the
shares  included in the  Registration  Statement  have been  distributed  to the
public.  Certain of the  selling  shareholders  will be  subject  to  applicable
provisions of the Exchange Act, and the rules and regulations  thereunder,  that
may  limit  the  timing  of  purchases  and  sales of  shares  by these  selling
shareholders.

         Paracelsian  agreed  to pay its own  legal  and  accounting  fees,  all
registration and filing fees attributable to the registration of the shares, any
legal fees and filing fees  relating to state  securities or "blue sky" filings,
and any printing  fees. The selling  stockholders  shall pay their own legal and
accounting fees and any other expense. Any commissions,  discounts or other fees
payable to  broker-dealers  in  connection  with any sale of the shares shall be
paid by the stockholder selling such shares.

         Paracelsian has also agreed to indemnify the selling  stockholders  and
their officers,  directors,  employees and agents,  and each person who controls
any selling stockholder,  in certain  circumstances against certain liabilities,
including liabilities arising under the Securities Act. Each selling stockholder
has agreed to indemnify  Paracelsian  and its  directors and officers in certain
circumstances  against certain liabilities,  including liabilities arising under
the Securities Act.

         None of the  selling  stockholders  are  obligated  to sell  any of the
Shares registered in this prospectus.

                                  LEGAL MATTERS

         Certain legal  matters in connection  with this offering will be passed
upon for Paracelsian by The Sanford  Holshouser Law Firm, PLLC, 219 Fayetteville
Street, Suite 1000, Raleigh, North Carolina 27601.

                                     EXPERTS

         The  consolidated   financial  statements  of  Paracelsian,   Inc.  and
subsidiary (a development  stage company) as of September 30, 1998 and 1997, and
for each of the  years  then  ended  and for the  period  from  April  15,  1991
(inception)  to  September  30,  1998,  have been  incorporated  by reference in
reliance upon the report of KPMG Peat Marwick LLP, independent  certified public
accountants,  incorporated  by reference  and upon the authority of said firm as
experts in accounting and auditing.

         The cumulative statements of operations, stockholders' equity, and cash
flows for the period April 15, 1991  (inception)  to September  30, 1998 include
amounts for the period from April 15, 1991 (inception) to September 30, 1991 and
for each of the years in the four-year  period ending  September 30, 1995, which
were  audited by other  auditors  whose  report has been  furnished  to KPMG LLP
("KPMG") and KPMG's opinion,  insofar as it relates to the amounts  included for
the period April 15, 1991 (inception) through September 30, 1995 is based solely
on the report of the other auditors.

                                       -8-

<PAGE>

                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.

         The following  table sets forth all expenses,  other than  underwriting
discounts and commissions, payable by the Registrant in connection with the sale
of the Common  Stock  being  registered.  All the amounts  shown are  estimates,
except for the registration fee.

           Registration fee                            $     1,286
           Legal fees and expenses                          10,000
           Accounting fees and expenses                      5,000
           Miscellaneous expenses                            2,000
                                                       -----------

                      TOTAL                            $    18,286

ITEM 15. INDEMNIFICATION OF OFFICERS AND DIRECTORS.

         Section  145  of  the   Delaware   General   Corporation   Law  permits
indemnification   of  officers  and  directors  of  the  Company  under  certain
conditions  and  subject to certain  limitations.  Section  145 of the  Delaware
General  Corporation  Law also  provides  that a  corporation  has the  power to
purchase and maintain  insurance on behalf of its officers and directors against
any  liability  asserted  against such person and incurred by him or her in such
capacity,  or  arising  out of his or her  status  as such,  whether  or not the
corporation  would have the power to indemnify him or her against such liability
under the provisions of Section 145 of the Delaware General Corporation Law.

         The Tenth Article of the  Certificate of  Incorporation  of the Company
provides that the Company shall  indemnify its directors and executive  officers
to the fullest extent  permitted by the Delaware  General  Corporation  Law. The
rights to  indemnity  thereunder  continue as to a person who has ceased to be a
director,  officer,  employee  or agent and inure to the  benefit  of the heirs,
executors and administrators of the person. In addition,  expenses incurred by a
director  or  officer  in  defending  any  civil,  criminal,  administrative  or
investigative action, suit or proceeding by reason of the fact that he or she is
or was a director or officer of the  Company  (or was  serving at the  Company's
request as a director  or officer of another  corporation)  shall be paid by the
Company in advance of the final  disposition of such action,  suit or proceeding
upon receipt of an  undertaking  by or on behalf of such  director or officer to
repay such amount if it shall  ultimately  be  determined  that he or she is not
entitled to be indemnified by the Company as authorized by the relevant  section
of the Delaware General Corporation Law.

         As permitted by Section 102(b) (7), of the Delaware General Corporation
Law, the Ninth Article of the Company's  Certificate of  Incorporation  provides
that a director  of the  Company  shall not be  personally  liable for  monetary
damages for breach of fiduciary duty as a director, except for liability (i) for
any breach of the director's duty of loyalty to the Company or its stockholders,
(ii) for acts or omissions  not in good faith or acts or omissions  that involve
intentional misconduct or a knowing violation of law, (iii) under Section 174 of
the Delaware General  Corporation Law or (iv) for any transaction from which the
director derived any improper personal benefit.

         The  Registrant  has an insurance  policy  covering the  directors  and
officers  of the  Registrant  with  respect  to certain  liabilities,  including
liabilities arising under the Securities Act or otherwise.

ITEM 16. EXHIBITS.

                                      II-1

<PAGE>

         EXHIBIT NO.         DESCRIPTION
         ----------          -----------

         5.1                 Opinion of The Sanford Holshouser Law Firm, PLLC

         23.1                Consent of KPMG LLP

         24.1                Power of Attorney. Reference is made to page II-4
                             of the Registration Statement.

ITEM 17. UNDERTAKINGS.

         The undersigned Registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a  post-effective  amendment  to this  registration  statement to reflect in the
prospectus  any  facts  or  events  arising  after  the  effective  date  of the
registration  statement (or the most recent  post-effective  amendment  thereof)
which,  individually or in the aggregate,  represent a fundamental change in the
information  set  forth  in  the  registration  statement.  Notwithstanding  the
foregoing,  any  increase or decrease  in volume of  securities  offered (if the
total  dollar  value of  securities  offered  would not  exceed  that  which was
registered) and any deviation from the low or high end of the estimated  maximum
offering  range  may be  reflected  in the  form of  prospectus  filed  with the
Commission pursuant to Rule 424 (b) (ss. 230.424 (b) of this chapter) if, in the
aggregate,  the changes in volume and price  represent no more than a 20% change
in the  maximum  aggregate  offering  price  set  forth in the  "Calculation  of
Registration Fee" table in the effective registration statement.

         (2) That,  for the  purpose  of  determining  any  liability  under the
Securities Act, each such  post-effective  amendment shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (3) To remove from registration by means of a post-effective  amendment
any of the securities being registered which remain unsold at the termination of
the offering.

         The  undersigned  Registrant  hereby  undertakes  that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
Registrant's  annual report  pursuant to Section 13 (a) or Section 15 (d) of the
Securities  Exchange  Act of 1934  (and,  where  applicable,  each  filing of an
employee  benefit  plan's  annual  report  pursuant  to  Section  15  (d) of the
Securities  Exchange  Act of 1934)  that is  incorporated  by  reference  in the
Registration  Statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         The undersigned  Registrant hereby undertakes to deliver or cause to be
delivered with the Prospectus,  to each person to whom the Prospectus is sent or
given,  the latest annual  report to security  holders that is  incorporated  by
reference  in  the  Prospectus  and  furnished   pursuant  to  and  meeting  the
requirements  of Rule 14a-3 or Rule 14c-3 under the  Securities  Exchange Act of
1934;  and,  where  interim  financial  information  required to be presented by
Article 3 of Regulation S-X are not set forth in the Prospectus,  to deliver, or
cause to be  delivered to each person to whom the  Prospectus  is sent or given,
the latest  quarterly  report that is specifically  incorporated by reference in
the Prospectus to provide such interim financial information.

         Insofar as indemnification for liabilities arising under the Securities
Act may be  permitted to  directors,  officers  and  controlling  persons of the
Company  pursuant to the  foregoing  provisions,  Delaware  Corporation  law, or
otherwise, the Registrant has been advised that in the opinion of the Securities
and  Exchange  Commission  such  indemnification  is  against  public  policy as
expressed in the Securities Act and is, therefore, unenforceable. In the

                                      II-2

<PAGE>

event that a claim for indemnification  against such liabilities (other than the
payment by the Registrant of expenses  incurred or paid by a director,  officer,
or controlling person of the Registrant in the successful defense of any action,
suit, or  proceeding)  is asserted by such  director,  officer,  or  controlling
person  in  connection  with the  securities  being  registered  hereunder,  the
Registrant  will,  unless in the opinion of its counsel  the  question  has been
settled by controlling precedent,  submit to a court of appropriate jurisdiction
the question of whether such  indemnification  by it is against public policy as
expressed in the Securities  Act and will be governed by the final  adjudication
of such issue.

                                   SIGNATURES

         Pursuant to the  requirements of the Securities Act, the Registrant has
duly cause this Amendment One to the Registration  Statement to be signed on its
behalf by the  undersigned,  thereunto duly  authorized,  in the City of Ithaca,
State of New York, on the 31st day of March, 1999.

                                PARACELSIAN, INC.

                             By: /s/ BERNARD LANDES
                                 ------------------
                                     Bernard Landes
                                     Chairman and Chief Executive Officer

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Amendment One to the Registration Statement has been signed pursuant to power of
attorney by the following persons in the capacities and on the dates indicated:

     Signature                Title                                 Date


/s/ BERNARD M. LANDES      Chairman of the Board and Chief        March 31, 1999
    -----------------
                           Executive Officer (Principal
                           Executive Officer)

/s/ BERNARD M. LANDES      Chief Financial Officer                March 31, 1999
    -----------------
                           (Principal Financial
                           and Accounting Officer)


/s/ BERNARD M. LANDES              Director                       March 31, 1999
- --------------------------         Chairman of the Board
    Bernard M. Landes

/s/ T. NELSON CAMPBELL             Director                       March 31, 1999
- --------------------------
    T. Nelson Campbell

                                   Director
- --------------------------
    James J. Dunseith

/s/ HIRA GURTOO                    Director                       March 31, 1999
- --------------------------
    Hira Gurtoo


                                      II-3

<PAGE>


/s/ LIANPING HE                    Director                       March 31, 1999
- --------------------------
    Lianping He

/s/ ROBERT A BUCHANAN, MD          Director                       March 31, 1999
- --------------------------
    Robert A. Buchanan, MD

/s/ THOMAS D. LIVINGSTON           Director                       March 31, 1999
- --------------------------
    Thomas D. Livingston.

/s/ T. COLIN CAMPBELL              Director                       March 31, 1999
- --------------------------
    T. Colin Campbell

/s/ LOREN ISRAELSEN                Director                       March 31, 1999
- --------------------------
    Loren Israelsen

                                      II-4


Exhibit 5.1
               [THE SANFORD HOLSHOUSER LAW FIRM, PLLC LETTERHEAD]

                              ______________, 1999

PARACELSIAN, Inc.
222 Langmuir Laboratories
Cornell Technology Park
Itacha, New York 14850

         Re:      7,316,180 Shares of Common Stock of Paracelsian, Inc.
                  -----------------------------------------------------

Ladies and Gentlemen:

         We have acted as counsel to PARACELSIAN,  Inc., a Delaware  corporation
(the  "Company"),  in connection with the  registration  of 7,316,180  shares of
common stock (the "Common  Stock"),  as described in the Company's  Registration
Statement on Form S-3 (the "Registration Statement"),  to be filed promptly with
the  Securities  and Exchange  Commission  under the  Securities Act of 1933, as
amended.

   
         In connection  with the issuance and sale of the Common Stock , we have
examined and are familiar with the Articles of Incorporation  and By-Laws of the
Company,  both as amended to date,  the records of the corporate  proceedings of
the Company,  and such other  documents and records we have deemed  relevant for
purposes of rendering  this opinion.  It is our opinion that the Common Stock is
validly issued, fully paid and nonassessable.
    

         We  consent  to  the  filing  of  this  opinion  as an  exhibit  to the
Registration  Statement  and to the  reference  to this firm  under the  caption
"Legal Matters" in the prospectus which is part of the  Registration  Statement.
Subject to the foregoing  sentence,  this opinion is given as of the date hereof
solely  for your  benefit  and may not be  relied  upon,  circulated,  quoted or
otherwise referred to for any purpose without our prior written consent.

                                   Sincerely,

                                   THE SANFORD HOLSHOUSER LAW FIRM






Exhibit 23.1



                Independent Certified Public Accountants' Consent


The Board of Directors
Paracelsian, Inc.:

We consent to the use of our report  incorporated herein by reference and to the
reference to our firm under the heading "Experts" in the prospectus.


                                                 KPMG LLP



Raleigh, North Carolina
March 31, 1999



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