PARACELSIAN INC /DE/
S-3, 1999-01-27
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                          AS FILED WITH THE SECURITIES
                   AND EXCHANGE COMMISSION ON JANUARY 25, 1999
                              REGISTRATION NO. 33-

- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  -------------

                                    FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                PARACELSIAN, INC.
             (Exact name of Registrant as Specified in Its Charter)

                  DELAWARE                                       56-1399565
         (State of Other Jurisdiction                         (I.R.S. Employer
          of Incorporation or Organization)                  Identification No.)

                            222 Langmuir Laboratories
                             Cornell Technology Park
                             Ithaca, New York 14850
                                 (607) 257-4224
        (Address, Including Zip Code and Telephone, Including Area Code,
                  of Registrant's Principal Executive Offices)

                                 Bernard Landes
                            222 Langmuir Laboratories
                             Cornell Technology Park
                             Ithaca, New York 14850
                                 (607) 257-4224
        (Address, Including Zip Code and Telephone, Including Area Code,
                  of Registrant's Principal Executive Offices)
                                   Copies to:
                             Ronald D. Raxter, Esq.
                      The Sanford Holshouser Law Firm, PLLC
                             219 Fayetteville Street
                                   Suite 1000
                          Raleigh, North Carolina 27601

         APPROXIMATE  DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:  From
time to time after the effective date of this Registration Statement.
<PAGE>

         If the only securities  being registered on this Form are being offered
pursuant to dividend or interest  reinvestment plans, please check the following
box. [ ]

         If any of the  securities  being  registered  on  this  Form  are to be
offered  on a  delayed  or  continuous  basis  pursuant  to Rule 415  under  the
Securities Act of 1933,  other than  securities  offered only in connection with
dividend or interest reinvestment plans, check the following box. [X]

         If this Form is filed to register additional securities for an offering
pursuant to Rule 462 (b) under the  Securities  Act,  please check the following
box and list the Securities  Act  registration  statement  number of the earlier
effective registration statement for the same offering. [ ]

         If this Form is a  post-effective  amendment filed pursuant to Rule 462
(c) under the  Securities  Act,  check the following box and list the Securities
Act  registration   statement  number  of  the  earlier  effective  registration
statement for the same offering. [ ]

         If delivery of the  prospectus  is expected to be made pursuant to Rule
434, please check the following box. [ ]

                         CALCULATION OF REGISTRATION FEE
- --------------------------------------------------------------------------------
TO BE REGISTERED  REGISTERED        PER SHARE (1)     PROPOSED          FEE
                                    OFFERING PRICE    MAXIMUM

Common Stock,     7,309,524 (2)     $0.88             $6,432,381       $1,286
$0.01 par value
per share

(1)      Estimated  solely  for the  purpose  of  computing  the  amount  of the
         registration  fee in accordance  with Rule 457 (c) under the Securities
         Act of 1933.

(2)      This  Registration  Statement shall also cover any additional shares of
         Common  Stock  which  become  issuable  in  connection  with the shares
         registered  for sale  hereby as a result of any stock  dividend,  stock
         split,  recapitalization or other similar transaction  effected without
         the receipt of consideration which results in an increase in the number
         of the Registrant's outstanding shares of Common Stock.

THE REGISTRANT HEREBY AMENDS THIS  REGISTRATION  STATEMENT ON SUCH DATE OR DATES
AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT  SHALL FILE
A FURTHER  AMENDMENT THAT SPECIFICALLY  STATES THAT THIS REGISTRATION  STATEMENT
SHALL  THEREAFTER  BECOME  EFFECTIVE  IN  ACCORDANCE  WITH  SECTION 8 (a) OF THE
SECURITIES  ACT OF  1933  OR  UNTIL  THE  REGISTRATION  STATEMENT  SHALL  BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8 (a),
MAY DETERMINE.

<PAGE>
                           SUBJECT TO COMPLETION

PROSPECTUS

                                PARACELSIAN, INC.
                                7,309,524 SHARES

                     COMMON STOCK, PAR VALUE $0.01 PER SHARE

         The shares offered hereby (the "Shares") consist of 7,309,524 shares of
common  stock,  par value $.01 per share (the  "Common  Stock") of  Paracelsian,
Inc., a Delaware corporation ("Paracelsian" or the "Company") which are owned by
the  selling   stockholders   listed   herein   under   "Selling   Stockholders"
(collectively,  the  "Selling  Stockholders").  The Shares were  acquired by the
Selling Stockholders pursuant to that certain transaction evidenced by the stock
purchase  agreement  dated January 14, 1998 and stock purchase  agreement  dated
December 15, 1998 (the "Transactions"). The Shares issued in the Transactions to
the  Selling   Stockholders   were  issued   pursuant  to  exemptions  from  the
registration  requirements  of the  Securities  Act of  1933,  as  amended  (the
"Securities Act"). In accordance with the terms of the Transactions, the Company
has agreed to register the Shares for resale by such Selling Stockholders.

         The Shares may be offered from time to time by the Selling Stockholders
after  the date of this  Prospectus.  The  Company  shall  pay all  expenses  of
registration incurred in connection with this offering, except that each Selling
Stockholder  shall pay any  commissions,  discounts,  or other  fees  payable to
broker-dealers  in connection with any sale of the Shares,  as well as legal and
accounting fees and expenses incurred by the Selling  Stockholders.  None of the
Shares have been registered prior to the filing of this  Registration  Statement
of which this  Prospectus  is a part.  The  Company  will not receive any of the
proceeds from the sale of the Shares by the Selling Stockholders.

         The Selling  Stockholders  have not advised the Company of any specific
plans for the distribution of the Shares covered by this Prospectus.  The Shares
may be sold from time to time on the National Association of Securities Dealers,
Inc.  ("NASD")  Electronic  Bulletin Board (the "Bulletin  Board") at the market
price  then   prevailing,   although  sales  may  also  be  made  in  negotiated
transactions or otherwise.  The Selling Stockholders and the brokers and dealers
through  whom  sales  of the  Common  Stock  may be  made  may be  deemed  to be
"underwriters"  within the meaning of the Securities Act, and their  commissions
or  discounts  and  other   compensation   may  be  regarded  as   underwriters'
compensation. See "Plan of Distribution."

         The  Common  Stock is quoted on the  Bulletin  Board  under the  symbol
"PRLN." On January __, 1999,  the last  reported  sale price of the Common Stock
was $______ per share.

         THE SHARES  OFFERED  INVOLVE A HIGH DEGREE OF RISK.  SEE "RISK FACTORS"
BEGINNING ON PAGE 3 FOR CERTAIN CONSIDERATIONS  RELEVANT TO AN INVESTMENT IN THE
COMMON STOCK.

THESE  SECURITIES  HAVE NOT BEEN APPROVED OR  DISAPPROVED  BY THE SECURITIES AND
EXCHANGE  COMMISSION OR ANY STATE  SECURITIES  COMMISSION NOR HAS THE SECURITIES
AND  EXCHANGE  COMMISSION  OR ANY STATE  SECURITIES  COMMISSION  PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.

                                ---------------

                  The date of this Prospectus is _______, 1999.
<PAGE>


                              AVAILABLE INFORMATION

         The  Company  is  subject  to  the  informational  requirements  of the
Securities  Exchange  Act of 1934,  as  amended  (the  "Exchange  Act"),  and in
accordance therewith, files reports, proxy statements and other information with
the  Securities  and Exchange  Commission  (the  "Commission").  Reports,  proxy
statements  and other  information  filed by the  Company may be  inspected  and
copied at the public reference  facilities  maintained by the Commission at Room
1024, 450 Fifth Street,  N.W., Judiciary Plaza,  Washington,  D.C. 20549, and at
the Commission's regional offices located at 7 World Trade Center, New York, New
York 10048 and Citicorp  Center,  500 W. Madison  Street,  Suite 1400,  Chicago,
Illinois  60661-2511;  and copies of such  materials  may be  obtained  from the
Public  Reference  Section  of  the  Commission,   Washington,  D.C.  20549,  at
prescribed  rates.  Copies of such  materials  may also be obtained from the web
site that the Commission maintains at http://www.sec.gov  that contains reports,
proxy and information  statements and other  information  regarding  registrants
that file electronically with the Commission.

         The Company has filed with the Commission a  Registration  Statement on
Form S-3 (herein, together with all amendments and exhibits,  referred to as the
"Registration  Statement")  under the  Securities Act with respect to the Shares
offered  hereby of which this  Prospectus is a part.  This  Prospectus  does not
contain all of the information set forth in the Registration Statement,  certain
portions of which are omitted in accordance  with the rules and  regulations  of
the  Commission.  For  further  information,  reference  is  hereby  made to the
Registration Statement and the exhibits and schedules thereto.

                      INFORMATION INCORPORATED BY REFERENCE

         The following  documents  filed by the Company with the  Commission are
hereby incorporated by reference in this Prospectus:

         1. The Annual  Report of the Company on Form 10-KSB for the fiscal year
ended September 30, 1998;

         2. The  description  of the  Company's  Common  Stock  contained in its
Registration Statement on Form S-1 filed on December 27, 1991; and

         3. All reports and other  documents  subsequently  filed by the Company
pursuant to Sections 13 (a), 13 (c), 14 or 15 (d) of the  Exchange Act after the
date of this Prospectus and prior to the termination of the Shares.

         Any  statement  incorporated  herein  shall be deemed to be modified or
superseded  for  purposes  of this  Prospectus  to the extent  that a  statement
contained herein or in any other subsequently filed document which also is or is
deemed to be  incorporated  by  reference  herein  modifies or  supersedes  such
statement.  Any statement so modified or superseded shall not be deemed,  except
as so modified or superseded, to constitute a part of this Prospectus.

         The Company  will  provide  without  charge to each person to whom this
Prospectus is delivered,  upon written or oral request of such person, a copy of
any or all of the foregoing  documents  incorporated  herein by reference (other
than  exhibits  to  such  documents,   unless  such  exhibits  are  specifically
incorporated by reference into any such  document).  Requests for such documents
should be  submitted  in  writing to the  Company,  222  Langmuir  Laboratories,
Cornell Technology Park, Ithaca, New York 14850 Attention:  Corporate  Secretary
or by telephone at (607)257-4224

         NO PERSON IS AUTHORIZED IN CONNECTION  WITH ANY OFFERING MADE HEREBY TO
GIVE ANY INFORMATION OR MAKE ANY REPRESENTATION NOT CONTAINED OR INCORPORATED BY
REFERENCE IN THIS PROSPECTUS,  AND ANY INFORMATION NOT CONTAINED OR INCORPORATED
HEREIN MUST NOT BE RELIED UPON AS HAVING BEEN  AUTHORIZED  BY THE COMPANY.  THIS
PROSPECTUS  DOES NOT CONSTITUTE AN OFFER TO SELL, OR A SOLICITATION  OF AN OFFER
TO BUY,  BY ANY  PERSON IN ANY  JURISDICTION  IN WHICH IT IS  UNLAWFUL  FOR SUCH
PERSON  TO MAKE  SUCH  OFFER  OR  SOLICITATION.  NEITHER  THE  DELIVERY  OF THIS
PROSPECTUS  AT  ANY  TIME  NOR  ANY  SALE  MADE  HEREUNDER   SHALL,   UNDER  ANY
CIRCUMSTANCES,  IMPLY THAT THE  INFORMATION IS CORRECT AS OF ANY DATE SUBSEQUENT
TO THE DATE HEREOF.

         Paracelsian and BioFIT are trademarks of the Company.

                                      -2-
<PAGE>

                           FORWARD LOOKING STATEMENTS

         This  Prospectus  may contain,  in addition to historical  information,
various  "forward looking  statements"  within the meaning of Section 27A of the
Securities Act and Section 21E of the Exchange Act, that represent the Company's
judgment  concerning the future and are subject to risks and uncertainties  that
could cause the Company's  actual  operating  results and financial  position to
differ materially from those projected in the forward looking  statements.  Such
forward  looking  statements  can be  identified  by the use of forward  looking
terminology,  such as "may,"  "will,"  "expect,"  "anticipate,"  "estimate,"  or
"continue"  or the negative  thereof or other  variations  thereof or comparable
terminology.  The Company cautions that any such forward looking  statements are
further  qualified by important  factors that could cause the  Company's  actual
operating  results and financial  position to differ materially from the forward
looking  statements,  including without limitation  considerations  described in
connection with specific forward looking  statements,  factors set forth in this
Prospectus under the caption "Risk Factors," and other cautionary statements set
forth in this  Prospectus.  The  Company  undertakes  no  obligation  to release
publicly the results of any  revisions to these  forward  looking  statements to
reflect events or circumstances arising after the date of this Prospectus.

                                     GENERAL

         Paracelsian is a development  stage  bioscience and technology  company
that utilizes its proprietary screening technology to identify novel therapeutic
compounds from herbal sources and to define the  biological  mechanisms  through
which herbal medicines affect cellular  function.  The screening  technology has
been developed by the Company to identify  potential  products that regulate the
biological  signals  generated by targeted  cells that result in  controlled  or
uncontrolled  cell  growth and  division.  The  Company's  screening  technology
evaluates the effects of herbal products on intracellular signals referred to as
"signal transduction technology".

         Cellular  signaling  is  one of  the  basic  steps  in  biology  and is
necessary for normal growth of tissues to support life. The Company's technology
enables  researchers to observe signal  transduction  and measure the effects of
chemicals contained in synthetic or natural compounds,  such as herbal extracts,
on  cellular  processes.  In the  course  of  these  studies,  the  Company  can
distinguish the effects of such chemicals on targeted cells,  thereby  screening
compounds  within  herbs and herbal  extracts to identify  those with  promising
therapeutic effects.

         The Company believes that the results of its research coincide with the
need for sound  scientific  understanding  of herbal  medicines.  The  Company's
technology provides tools for the definition of solid and valid scientific bases
for the beneficial  health effects of herbal medicines and dietary  supplements.
In  addition,  the Company has utilized  its  technology  to screen and identify
active substances contained within its library of traditional Chinese medicines.

         The Company has the ability to develop novel  procedures  for detecting
biologically  relevant  activities of complex  mixtures of compounds (such as in
the herbal extracts) or of the active constituents thereof. These procedures are
generally  referred to as bioassays.  The  Company's  assay  technology  enables
researchers  to measure the effects of  chemicals  contained  in  synthetic  and
natural  compounds on normal and  abnormal  cell  division and other  biological
processes.  The ability to conduct in vitro  screening of  biological  activity,
quickly without lengthy and costly animal testing,  is a significant  innovation
for  researchers  in the  pharmaceutical,  agrochemical,  herbal  supplement and
environmental testing industries.

         The Company has operated at a loss since its  formation in 1991.  There
can be no assurance  that the Company will ever achieve  profitable  operations.
See "Risk Factors."

         Paracelsian  was  incorporated  in  Delaware  in  1991.  Its  principal
executive offices are located at 222 Langmuir  Laboratories,  Cornell Technology
Park, Ithaca, New York 14850 and its telephone number is (607) 257-4224.

                                      -3-
<PAGE>

                                  RISK FACTORS

         IN ADDITION  TO THE OTHER  INFORMATION  CONTAINED  OR  INCORPORATED  BY
REFERENCE  IN  THIS  PROSPECTUS,  PROSPECTIVE  PURCHASERS  SHOULD  CONSIDER  THE
FOLLOWING FACTORS CAREFULLY IN EVALUATING THE COMPANY AND ITS BUSINESS. SEE ALSO
"FORWARD LOOKING STATEMENTS."

DEVELOPMENT STAGE COMPANY AND LIMITED OPERATING HISTORY

         The Company is considered to be a development  stage company.  Although
the  Company  commenced  operations  in  April  1991,  it has  yet  to  generate
significant  revenues and has no assurance of substantial  future revenues.  The
Company has been engaged primarily in research,  product engineering and raising
capital.  In  January  1998,  the  Company  acquired  an  entirely  new Board of
Directors and executive management. New management has substantially altered the
business  plan for the Company with the aim of  generating  operating  revenues.
Unless the Company is successful with its business plan, it may be several years
before  significant  revenues  are  realized.  Revenues  for  fiscal  1998  were
approximately  $56,000.  Future  revenues  will be  derived  from  sales  of the
Company's  services  that are  currently  under  development  and  royalties  in
connection with licensing of its technology.  There can be no assurance that the
Company will be able to attain such  revenues in  sufficient  amounts to achieve
profitable operations. Results of operations in the future will be influenced by
numerous factors, including the ability of the Company to develop and manage the
introduction of its new services,  market acceptance of the Company's  services,
competition and the ability to control costs.

LIQUIDITY AND CAPITAL RESOURCES

          As of September  30, 1998 the Company  maintained  working  capital of
approximately $219,000 which included approximately $250,000 of cash. Subsequent
to fiscal year end,  in  December  1998,  the  Company  raised  $250,000 in cash
through  a private  placement  of its stock at the then  current  market  value.
Management  believes  that these  resources  are  adequate  to  provide  for its
operating  needs until such time as its  revenue  stream  commences.  Management
further believes that it can successfully  raise additional capital if necessary
to support its continued  operations  until such time as revenues are sufficient
to provide  internally  generated funds. The Company presently intends to pursue
additional  capital of $1 million to $1.5 million in the near term, if available
on  reasonable  terms,  to  provide  resources  for  the  hiring  of  additional
personnel,  expansion and/or relocation of lab facilities,  and the acceleration
of product  development  efforts.  Of  course,  there can be no  assurance  that
additional  financing  will be  available  on  acceptable  terms  or at all.  If
adequate  funds are not available from  operations or sources of financing,  the
Company's business will be materially adversely affected.

LIMITED TRADING MARKET

         The  Common  Stock is  currently  traded  on the  Bulletin  Board  (the
electronic  pink sheets)  under the symbol  "PRLN."  There is no assurance  that
holders of the Common  Stock will be able to resell  their  shares in the future
for a price per share  that is equal to or more  than the  current  price of the
Common Stock due to the limited trading market for the Common Stock.

DEPENDENCE ON A KEY DISTRIBUTOR AND CERTAIN INDUSTRIES

         The Company's initial revenues are highly dependent upon the ability to
market the BioFIT  designation in the herbal and dietary  supplement market. The
Company has entered into an agreement with a leading  manufacturer of herbal and
other dietary supplement  products to serve as the Company's exclusive agent for
the marketing and distribution of its BioFIT Certification  Program. The Company
must therefore  rely to a substantial  degree on this company for the successful
and timely  launch of its BioFIT  program.  Failure to launch BioFIT in a timely
manner or  failure  to secure an  adequate  number  of  customers  could  have a
material adverse effect on the Company.  The Company's  operations could also be
materially and adversely  affected by a general  economic  decline in the herbal
and dietary supplement industries.

DEPENDENCE ON PERSONNEL

         The Company does not currently  have a complete  management  team.  Key
positions  not yet filled  include Chief  Financial  Officer,  Chief  Operations
Officer,  Vice President of Science, and Vice President of Business Development.
Presently, these functions are performed by Bernard Landes, Ph.D., the Company's
Chairman,  President and Chief Executive Officer, assisted by certain members of
the Company's  Board of Directors.  The loss of the services of Mr. Landes could
have a material  adverse  effect on the  Company.  In  addition,  the  Company's
performance  depends on its ability to attract and retain  qualified  management
and  professional,  scientific  and technical  operating  staff,  as well as its
ability to recruit  qualified  representatives  for its contract sales services.
There can be no  assurance  that the Company will be able to continue to attract
and retain qualified personnel.

                                       -4-
<PAGE>

POTENTIAL LIABILITY

         In connection with the provision of its services,  the Company could be
held  liable  for  errors  or  omissions.  The  Company  maintains  professional
liability  insurance  that  includes  safety  issues as well as data  processing
errors and omissions. There can be no assurance that the Company will be able to
maintain such insurance coverage on terms acceptable to the Company. The Company
could be materially and adversely affected if it were required to pay damages or
bear the costs of  defending  any claim  outside  the scope of or in excess of a
contractual  indemnification provision or beyond the level of insurance coverage
or in the event that an indemnifying party does not fulfill its  indemnification
obligations.

UNPREDICTABILITY OF PATENT PROTECTION; PROPRIETARY TECHNOLOGY

          Certain of the  technologies  utilized in the  Company's  products are
proprietary.  The  Company  believes  that patent  protection  of  materials  or
processes  it  develops  and any  products  that may result  from the  Company's
research and development efforts are important to the possible commercialization
of the  Company's  products.  The  Company  currently  has US patent  protection
regarding the use of compounds  identified from two of its  traditional  Chinese
medicine extracts and for its improved Ah-IMMUNOASSAY technology. However, there
can be no assurance that the Company's  patents will afford adequate  protection
to the Company or its  licensees.  Further,  there can be no assurance  that any
patents  that  have  been  or  may be  issued  will  provide  the  Company  with
significant  protection from competitors.  Other private and public entities may
file applications for patents and other  proprietary  rights to technology which
could  be  harmful  to the  commercialization  of  the  Company's  services  and
products.  The ultimate  scope and validity of patents which are now owned by or
which may be granted to third  parties  in the  future,  the extent to which the
Company may wish or be required to acquire  rights under such  patents,  and the
cost or  availability of such rights cannot be determined by the Company at this
time. In addition,  the Company also relies on unpatented proprietary technology
in the development and commercialization of its services and products.  There is
no  assurance  that  others may not  independently  develop  the same or similar
technology or obtain access to the Company's proprietary  technology or disclose
such technology or that the Company can meaningfully  protect its rights in such
unpatented proprietary technology.

         In addition,  although all of the  Company's  employees  are parties to
confidentiality   agreements   which  are  intended  to  protect  the  Company's
proprietary  technology,  there can be no assurance  that any of such  employees
will not compromise any of the Company's proprietary rights.

DIRECTOR AND EXECUTIVE OFFICER STOCK OWNERSHIP

         The directors and executive officers of the Company beneficially own or
have voting  control over  7,153,477  shares of Common Stock,  or  approximately
38.07% of the  Company's  outstanding  shares of Common Stock as of December 22,
1998.  Such  directors  and  executive  officers are  therefore in a position to
significantly  influence  the election of the  Company's  directors  and thereby
select management and direct policies of the Company.

                                      -5-
<PAGE>

VOLATILITY OF STOCK PRICE

         The market  price of the Common  Stock has been and may  continue to be
subject to wide fluctuations in response to variations in operating results from
quarter to quarter,  market  conditions  in the  industry  and general  economic
conditions.

NON-PAYMENT OF CASH DIVIDENDS

         The Company has not paid any cash dividends and it is unlikely that the
Company will pay any cash dividends in the foreseeable future. Earnings, if any,
will be retained by the Company for further  development  and  expansion  of its
business.  There  can be no  assurance  that  the  Company  will  ever  pay cash
dividends.

EFFECTS OF ISSUANCE OF PREFERRED STOCK

         The Company's  Articles of Incorporation  authorized the issuance of up
to  1,000,000  shares  of  preferred  stock on terms  which  may be fixed by the
Company's  Board of Directors  without  further  shareholder  action.  While the
Company has previously  issued shares of preferred stock, as of the date of this
Prospectus, the Company has no shares of preferred stock outstanding.  The terms
of any future series of preferred  stock,  which may include  priority claims to
assets and dividends  and special  voting  rights,  could  adversely  affect the
rights of holders of the Common  Stock.  The  issuance of such  preferred  stock
could make the possible  takeover of the Company or the removal of management of
the Company more difficult,  discourage  hostile bids for control of the Company
in which  shareholders may receive premiums for their shares of Common Stock, or
otherwise  dilute the rights of holders of Common  Stock and the market price of
the Common Stock.

                                 USE OF PROCEEDS

         The Shares  being  offered  hereby are for the  account of the  Selling
Stockholders and the Company is not selling any of the Shares. Accordingly,  the
Company  will not receive  any  proceeds  from the sale of Shares.  See "Plan of
Distribution."


                                      -6-

<PAGE>


                              SELLING STOCKHOLDERS

         The Selling  Stockholders  received the Shares in  connection  with the
Transactions.  The following table sets forth certain information as of the date
of this Prospectus.  All of the Shares being offered by the Selling Stockholders
may be sold  pursuant to this  Prospectus.  The Shares are being  registered  to
permit public secondary  trading in the Shares and the Selling  Stockholders may
offer the Shares for resale from time to time. See "Plan of Distribution."
<TABLE>
<CAPTION>

                                    Shares                             Shares
                                    Beneficially              Shares   Beneficially
                                    Owned Prior               Being    Owned After
                                    to Offering               Offered  Offering
                                    ------------------------  -------- ---------------------
                                    Number        Percent(1)  Number             Percent (1)
                                    ------        -------     ------             -------

<S>                                 <C>           <C>        <C>           <C>      <C>
Biomar International, Inc.          6,025,575     32.24      6,025,575    -0-      -0-
John A. Williams                      758,666      4.06        666,666   92,000     *
Bernard Landes                        203,000      1.09        100,000  103,000     *
C. David Smith                        100,000       *          100,000    -0-      -0-
Thomas D. Livingston                  208,095      1.11        200,000    8,095     *
Thomas H. Evans                        50,000       *           50,000    -0-      -0-
Sylvestor Johnson IV                  117,283       *          117,283    -0-      -0-
G.W. Thorpe                            50,000       *           50,000    -0-      -0-
</TABLE>

- --------------------

         * Denotes beneficial ownership of less than one percent of the Shares.

(1)      Based on the 18,690,253  Shares which were issued and outstanding as of
         December 22, 1998.

                              PLAN OF DISTRIBUTION

         The Shares offered hereby by the Selling  Stockholders may be sold from
time to time by the Selling Stockholders,  or by pledges, donees, transferees or
other successors in interest. The decision to offer and sell the Shares, and the
timing and  amount of any  offers or sales that are made,  is and will be within
the sole  discretion  of the Selling  Stockholders.  The Shares may be sold from
time to time on the Bulletin  Board,  at prices then  prevailing,  in negotiated
transactions  or  otherwise.  The  Shares  may be  sold  by one or  more  of the
following  methods,  without  limitation:   (a)  a  block  trade  in  which  the
broker-dealer  so  engaged  will  attempt  to sell the  Shares  as agent but may
position  and  resell a portion  of the block as  principal  to  facilitate  the
transaction; (b) purchases by a broker or dealer as principal and resale by such
broker or dealer for its  account  pursuant  to this  Prospectus;  (c)  ordinary
brokerage transactions and transactions in which the broker solicits purchasers;
and (d) privately  negotiated  transactions between the Selling Stockholders and
purchasers  without a  broker-dealer.  In  effecting  sales,  brokers or dealers
engaged by the Selling  Stockholders may arrange for other brokers or dealers to
participate.  Such brokers or dealers may receive  commissions or discounts from
the Selling  Stockholders.  The Selling Stockholders and the brokers and dealers
through whom sales of the Shares may be made may be deemed to be  "underwriters"
within the meaning of the Securities Act, and their commissions or discounts and
other compensation may be regarded as underwriters'  compensation.  In addition,
any securities covered by this Prospectus that qualify for sale pursuant to Rule
144 under the  Securities  Act might be sold under Rule 144 rather than pursuant
to this Prospectus.

                                      -7-
<PAGE>

         The Company  anticipates that the  Registration  Statement shall remain
effective until the date on which all of the Shares included in the Registration
Statement  have  been  distributed  to  the  public.   Certain  of  the  Selling
Shareholders  will be subject to applicable  provisions of the Exchange Act, and
the rules and regulations thereunder, that may limit the timing of purchases and
sales of Shares by the Selling Shareholders.

         The  Company  shall  pay  its  own  legal  and  accounting   fees,  all
registration and filing fees attributable to the registration of the Shares, any
legal fees and filing fees  relating to state  securities or "blue sky" filings,
the filing fee payable to the Bulletin Board,  and all printing fees incurred in
connection  herewith.  Each  Selling  Stockholder  shall pay his, her or its own
legal  and  accounting  fees  and any  other  expense  incurred  by the  Selling
Stockholder. Any commissions,  discounts or other fees payable to broker-dealers
in  connection  with any  sale of the  Shares  shall  be  borne  by the  Selling
Stockholder selling such Shares.

         The Company has agreed to indemnify the Selling  Stockholders and their
officers,  directors,  employees  and agents,  and each person who  controls any
Selling  Stockholder,  in certain  circumstances  against  certain  liabilities,
including liabilities arising under the Securities Act. Each Selling Stockholder
has agreed to indemnify  the Company and its  directors  and officers in certain
circumstances  against certain liabilities,  including liabilities arising under
the Securities Act.

         There can be no assurance that the Selling  Stockholders  will sell any
or all of the Shares offered by them hereunder.

                                  LEGAL MATTERS

         Certain legal  matters in connection  with this offering will be passed
upon for the Company by The Sanford  Holshouser Law Firm, PLLC, 219 Fayetteville
Street, Suite 1000, Raleigh, North Carolina 27601.

                                     EXPERTS

         The  consolidated   financial  statements  of  Paracelsian,   Inc.  and
subsidiary (a development  stage company) as of September 30, 1998 and 1997, and
for each of the  years  then  ended  and for the  period  from  April  15,  1991
(inception)  to  September  30,  1998,  have been  incorporated  by reference in
reliance upon the report of KPMG Peat Marwick LLP, independent  certified public
accountants,  incorporated  by reference  and upon the authority of said firm as
experts in accounting and auditing.

         The cumulative statements of operations, stockholders' equity, and cash
flows for the period April 15, 1991  (inception)  to September  30, 1998 include
amounts for the period from April 15, 1991 (inception) to September 30, 1991 and
for each of the years in the four-year  period ending  September 30, 1995, which
were  audited by other  auditors  whose  report has been  furnished to KPMG Peat
Marwick LLP  ("KPMG") and KPMG's  opinion,  insofar as it relates to the amounts
included for the period April 15, 1991 (inception) through September 30, 1995 is
based solely on the report of the other auditors.

                                      -8-
<PAGE>

                                      II -1

                                     PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.

         The following  table sets forth all expenses,  other than  underwriting
discounts and commissions, payable by the Registrant in connection with the sale
of the Common  Stock  being  registered.  All the amounts  shown are  estimates,
except for the registration fee.

                  Registration fee                             $    1,286
                  Legal fees and expenses                          10,000
                  Accounting fees and expenses                      5,000
                  Miscellaneous expenses                            2,000
                                                               ----------
                           TOTAL                               $   18,286
                                                               ==========

ITEM 15.  INDEMNIFICATION OF OFFICERS AND DIRECTORS.

         Section  145  of  the   Delaware   General   Corporation   Law  permits
indemnification   of  officers  and  directors  of  the  Company  under  certain
conditions  and  subject to certain  limitations.  Section  145 of the  Delaware
General  Corporation  Law also  provides  that a  corporation  has the  power to
purchase and maintain  insurance on behalf of its officers and directors against
any  liability  asserted  against such person and incurred by him or her in such
capacity,  or  arising  out of his or her  status  as such,  whether  or not the
corporation  would have the power to indemnify him or her against such liability
under the provisions of Section 145 of the Delaware General Corporation Law.

         The Tenth Article of the  Certificate of  Incorporation  of the Company
provides that the Company shall  indemnify its directors and executive  officers
to the fullest extent  permitted by the Delaware  General  Corporation  Law. The
rights to  indemnity  thereunder  continue as to a person who has ceased to be a
director,  officer,  employee  or agent and inure to the  benefit  of the heirs,
executors and administrators of the person. In addition,  expenses incurred by a
director  or  officer  in  defending  any  civil,  criminal,  administrative  or
investigative action, suit or proceeding by reason of the fact that he or she is
or was a director or officer of the  Company  (or was  serving at the  Company's
request as a director  or officer of another  corporation)  shall be paid by the
Company in advance of the final  disposition of such action,  suit or proceeding
upon receipt of an  undertaking  by or on behalf of such  director or officer to
repay such amount if it shall  ultimately  be  determined  that he or she is not
entitled to be indemnified by the Company as authorized by the relevant  section
of the Delaware General Corporation Law.

         As permitted by Section 102(b) (7), of the Delaware General Corporation
Law, the Ninth Article of the Company's  Certificate of  Incorporation  provides
that a director  of the  Company  shall not be  personally  liable for  monetary
damages for breach of fiduciary duty as a director, except for liability (i) for
any breach of the director's duty of loyalty to the Company or its stockholders,
(ii) for acts or omissions  not in good faith or acts or omissions  that involve
intentional misconduct or a knowing violation of law, (iii) under Section 174 of
the Delaware General  Corporation Law or (iv) for any transaction from which the
director derived any improper personal benefit.

         The  Registrant  has an insurance  policy  covering the  directors  and
officers  of the  Registrant  with  respect  to certain  liabilities,  including
liabilities arising under the Securities Act or otherwise.

ITEM 16.  EXHIBITS.

         EXHIBIT NO.        DESCRIPTION
         -----------        -----------

         5.1                Opinion of The Sanford Holshouser Law Firm, PLLC

         23.1               Consent of KPMG Peat Marwick LLP

         24.1               Power of Attorney.  Reference is made to page II-4.

ITEM 17.  UNDERTAKINGS.

         The undersigned Registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a  post-effective  amendment  to this  registration  statement to reflect in the
prospectus  any  facts  or  events  arising  after  the  effective  date  of the
registration  statement (or the most recent  post-effective  amendment  thereof)
which,  individually or in the aggregate,  represent a fundamental change in the
information  set  forth  in  the  registration  statement.  Notwithstanding  the
foregoing,  any  increase or decrease  in volume of  securities  offered (if the
total  dollar  value of  securities  offered  would not  exceed  that  which was
registered) and any deviation from the low or high end of the estimated  maximum
offering  range  may be  reflected  in the  form of  prospectus  filed  with the
Commission pursuant to Rule 424 (b) (ss. 230.424 (b) of this chapter) if, in the
aggregate,  the changes in volume and price  represent no more than a 20% change
in the  maximum  aggregate  offering  price  set  forth in the  "Calculation  of
Registration Fee" table in the effective registration statement.

         (2) That,  for the  purpose  of  determining  any  liability  under the
Securities Act, each such  post-effective  amendment shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.


<PAGE>

                                      II -1

         (3) To remove from registration by means of a post-effective  amendment
any of the securities being registered which remain unsold at the termination of
the offering.

         The  undersigned  Registrant  hereby  undertakes  that, for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
Registrant's  annual report  pursuant to Section 13 (a) or Section 15 (d) of the
Securities  Exchange  Act of 1934  (and,  where  applicable,  each  filing of an
employee  benefit  plan's  annual  report  pursuant  to  Section  15  (d) of the
Securities  Exchange  Act of 1934)  that is  incorporated  by  reference  in the
Registration  Statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         The undersigned  Registrant hereby undertakes to deliver or cause to be
delivered with the Prospectus,  to each person to whom the Prospectus is sent or
given,  the latest annual  report to security  holders that is  incorporated  by
reference  in  the  Prospectus  and  furnished   pursuant  to  and  meeting  the
requirements  of Rule 14a-3 or Rule 14c-3 under the  Securities  Exchange Act of
1934;  and,  where  interim  financial  information  required to be presented by
Article 3 of Regulation S-X are not set forth in the Prospectus,  to deliver, or
cause to be  delivered to each person to whom the  Prospectus  is sent or given,
the latest  quarterly  report that is specifically  incorporated by reference in
the Prospectus to provide such interim financial information.

         Insofar as indemnification for liabilities arising under the Securities
Act may be  permitted to  directors,  officers  and  controlling  persons of the
Company  pursuant to the  foregoing  provisions,  Delaware  Corporation  law, or
otherwise, the Registrant has been advised that in the opinion of the Securities
and  Exchange  Commission  such  indemnification  is  against  public  policy as
expressed in the Securities Act and is, therefore,  unenforceable.  In the event
that a claim  for  indemnification  against  such  liabilities  (other  than the
payment by the Registrant of expenses  incurred or paid by a director,  officer,
or controlling person of the Registrant in the successful defense of any action,
suit, or  proceeding)  is asserted by such  director,  officer,  or  controlling
person  in  connection  with the  securities  being  registered  hereunder,  the
Registrant  will,  unless in the opinion of its counsel  the  question  has been
settled by controlling precedent,  submit to a court of appropriate jurisdiction
the question of whether such  indemnification  by it is against public policy as
expressed in the Securities  Act and will be governed by the final  adjudication
of such issue.

                                   SIGNATURES

         Pursuant to the  requirements of the Securities Act, the Registrant has
duly  cause  this  Registration  Statement  to be  signed  on its  behalf by the
undersigned,  thereunto  duly  authorized,  in the City of Ithaca,  State of New
York, on the 22nd day of January, 1999.

                             PARACELSIAN, INC.

                             By:  /s/  BERNARD LANDES
                                -----------------------------------------
                                       Bernard Landes
                                       Chairman and Chief Executive Officer


                                POWER OF ATTORNEY

         KNOW ALL PERSONS BY THESE  PRESENTS,  that each person whose  signature
appears below hereby  constitutes and appoints,  jointly and severally,  Bernard
Landes and T.  Nelson  Campbell,  and each of them acting  individually,  as his
attorney-in-fact,  each with full power of substitution and  resubstituion,  for
him or her in any and all  capacities,  to sign any and all  amendments  to this
Registration Statement (including  post-effective  amendments),  and to file the
same, with exhibits  thereto and other documents in connection  therewith,  with
the Securities  and Exchange  Commission,  granting unto said  attorneys-in-fact
full  power  and  authority  to do and  perform  each and  every  act and  thing
requisite  and  necessary  to be done in  connection  therewith  as fully to all
intents and  purposes as he might or could do in person,  hereby  ratifying  and
confirming all that said attorneys-in-fact,  or their substitute or substitutes,
may lawfully do or cause to be done by virtue hereof.

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated:

<TABLE>
<CAPTION>
      Signature                         Title                                   Date
      ---------                         -----                                   ----


<S>                           <C>                                         <C> 
/s/ BERNARD M. LANDES         Chairman of the Board and Chief             January 22, 1999
- --------------------------    Executive Officer (Principal Executive
    Bernard M. Landes         Officer)

/s/ BERNARD M. LANDES         Chief Financial Officer                     January 22, 1999
- --------------------------    (Principal Financial
    Bernard M. Landes         and Accounting Officer)



/s/ BERNARD M. LANDES         Director                                    January 22, 1999
- --------------------------    Chairman of the Board
    Bernard M. Landes

/s/ T. NELSON CAMPBELL        Director                                    January 22, 1999
- --------------------------
    T. Nelson Campbell

                              Director
- --------------------------
    James J. Dunseith

/s/ HIRA GURTOO               Director                                    January 22, 1999
- --------------------------
    Hira Gurtoo

/s/ LIANPING HE               Director                                    January 22, 1999
- --------------------------
    Lianping He

/s/ ROBERT A. BUCHANAN, MD    Director                                    January 22, 1999
- --------------------------
    Robert A. Buchanan, MD

/s/ THOMAS D. LIVINGSTON      Director                                    January 22, 1999
- --------------------------
    Thomas D. Livingston.

/s/ T. COLIN CAMPBELL         Director                                    January 22, 1999
- --------------------------
    T. Colin Campbell

/s/ LOREN ISRAELSEN           Director                                    January 21, 1999
- --------------------------
    Loren Israelsen
</TABLE>




                                                                     Exhibit 5.1

               [THE SANFORD HOLSHOUSER LAW FIRM, PLLC LETTERHEAD]

                                                         ______________, 1998

PARACELSIAN, Inc.
222 Langmuir Laboratories
Cornell Technology Park
Ithaca, New York 14850

         Re:  7,309,524 Shares of Common Stock of Company
              -------------------------------------------

Ladies and Gentlemen:

         We have acted as counsel to PARACELSIAN,  Inc., a Delaware  corporation
(the  "Company"),  in connection with the  registration  of 7,309,524  shares of
Common Stock (the "Common  Stock"),  as described in the Company's  Registration
Statement on Form S-3 (the "Registration Statement"),  to be filed promptly with
the  Securities  and Exchange  Commission  under the  Securities Act of 1933, as
amended.

         We are familiar with the corporate  proceedings taken by the Company in
connection  with the  issuance and sale of the Common  Stock.  It is our opinion
that the Common Stock is validly issued, fully paid and nonassessable.

         We  consent  to  the  filing  of  this  opinion  as an  exhibit  to the
Registration  Statement  and to the  reference  to this firm  under the  caption
"Legal Matters" in the Prospectus which is part of the  Registration  Statement.
Subject to the foregoing  sentence,  this opinion is given as of the date hereof
solely  for your  benefit  and may not be  relied  upon,  circulated,  quoted or
otherwise referred to for any purpose without our prior written consent.

                                        Sincerely,

                                        THE SANFORD HOLSHOUSER LAW FIRM





                                                                    Exhibit 23.1


                Independent Certified Public Accountants' Consent


The Board of Directors
Paracelsian, Inc.:

We consent to the use of our report  incorporated herein by reference and to the
reference to our firm under the heading "Experts" in the prospectus.


                                    KPMG Peat Marwick LLP




Raleigh, North Carolina
January      , 1999



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