I STAT CORPORATION /DE/
SC 13G/A, 1998-01-27
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
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                                  UNITED STATES      
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                    

                                  SCHEDULE 13G







                    Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*


                                     I-STAT
- --------------------------------------------------------------------------------
                                (Name of Issuer)
                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)
                                    450312103
- --------------------------------------------------------------------------------
                                 (CUSIP Number)



*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

<PAGE>

<TABLE>
<CAPTION>

     <S>                                                                             <C>
- ---------------------------------------                                         --------------------------------------
CUSIP No.   450312103                                    13G                    Page  2  of  9  Pages
- ---------------------------------------                                         --------------------------------------

- --------- -------------------------------------------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

          John Hancock Mutual Life Insurance Company
          I.R.S. No. 04-1414660
- --------- -------------------------------------------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                      (a)  |_|

                                                                                 (b)  |_|
          N/A
- --------- -------------------------------------------------------------------------------------------------------------------
   3      SEC USE ONLY

- --------- -------------------------------------------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION

          Commonwealth of Massachusetts

- --------- -------------------------------------------------------------------------------------------------------------------
                   -------- -----------------------------------------------------------------------------------------------
                      5     SOLE VOTING POWER
    Number of
     Shares                 -0-

                   -------- -----------------------------------------------------------------------------------------------
  Beneficially        6     SHARED VOTING POWER
    Owned by
      Each                  -0-

                   -------- -----------------------------------------------------------------------------------------------
    Reporting         7     SOLE DISPOSITIVE POWER
     Person
      With                  -0-

                   -------- -----------------------------------------------------------------------------------------------
                      8     SHARED DISPOSITIVE POWER

                            -0-

                   -------- -----------------------------------------------------------------------------------------------
- --------- -------------------------------------------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          None,  except  through its  indirect,  wholly-owned  subsidiary,  John
          Hancock Advisers, Inc.

- --------- -------------------------------------------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

          N/A
- --------- -------------------------------------------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          See line 9, above.

- --------- -------------------------------------------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          IC, IA, HC

- --------- -------------------------------------------------------------------------------------------------------------------
                                       *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                                 PAGE 2 OF 9 PAGES


<PAGE>


     <S>                                                                             <C>
- ---------------------------------------                                         --------------------------------------
CUSIP No.   450312103                                    13G                    Page  3  of  9  Pages
- ---------------------------------------                                         --------------------------------------

- --------- ---------------------------------------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

          John Hancock Subsidiaries, Inc.
          I.R.S. No. 04-2687223
- --------- ---------------------------------------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                      (a)  |_|

                                                                                 (b)  |_|
         N/A
- --------- ---------------------------------------------------------------------------------------------------------------
   3      SEC USE ONLY

- --------- ---------------------------------------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware

- --------- ---------------------------------------------------------------------------------------------------------------
                  --------- ---------------------------------------------------------------------------------------------
                     5      SOLE VOTING POWER
   Number of
     Shares                 -0-

                  --------- ---------------------------------------------------------------------------------------------
  Beneficially       6      SHARED VOTING POWER
    Owned by
      Each                  -0-

                  --------- ---------------------------------------------------------------------------------------------
   Reporting         7      SOLE DISPOSITIVE POWER
     Person
      With                  -0-

                  --------- ---------------------------------------------------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            -0-

                  --------- ---------------------------------------------------------------------------------------------
- --------- ---------------------------------------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          None,  except  through its  indirect,  wholly-owned  subsidiary,  John
          Hancock Advisers, Inc.
- --------- ---------------------------------------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

          N/A
- --------- ---------------------------------------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          See line 9, above.

- --------- ---------------------------------------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          HC

- --------- ---------------------------------------------------------------------------------------------------------------
                                       *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                                 PAGE 3 OF 9 PAGES


<PAGE>


     <S>                                                                             <C>
- ---------------------------------------                                         --------------------------------------
CUSIP No.   450312103                                    13G                    Page  4  of  9  Pages
- ---------------------------------------                                         --------------------------------------

- --------- ---------------------------------------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

          The Berkeley Financial Group
          I.R.S. No. 04-3145626
- --------- ---------------------------------------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                      (a)  |_|

                                                                                 (b)  |_|
          N/A
- --------- ---------------------------------------------------------------------------------------------------------------
   3      SEC USE ONLY

- --------- ---------------------------------------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION

          Commonwealth of Massachusetts

- --------- ---------------------------------------------------------------------------------------------------------------
                   -------- ---------------------------------------------------------------------------------------------
                      5     SOLE VOTING POWER
    Number of
     Shares                 -0-

                   -------- ---------------------------------------------------------------------------------------------
  Beneficially        6     SHARED VOTING POWER
    Owned by
      Each                  -0-

                   -------- ---------------------------------------------------------------------------------------------
    Reporting         7     SOLE DISPOSITIVE POWER
     Person
      With                  -0-

                   -------- ---------------------------------------------------------------------------------------------
                      8     SHARED DISPOSITIVE POWER

                            -0-

                   -------- ---------------------------------------------------------------------------------------------
- --------- ---------------------------------------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          None,  except  through its  indirect,  wholly-owned  subsidiary,  John
          Hancock Advisers, Inc.
- --------- ---------------------------------------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

          N/A
- --------- ---------------------------------------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          See line 9, above.

- --------- ---------------------------------------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          HC

- --------- ---------------------------------------------------------------------------------------------------------------
                                       *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                                 PAGE 4 OF 9 PAGES


<PAGE>


     <S>                                                                             <C>
- ---------------------------------------                                         --------------------------------------
CUSIP No.   450312103                                    13G                    Page  5  of  9  Pages
- ---------------------------------------                                         --------------------------------------

- --------- ---------------------------------------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

          John Hancock Advisers, Inc.
          I.R.S. No. 04-2441573

- --------- ---------------------------------------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                      (a)  |_|

                                                                                 (b)  |_|
          N/A
- --------- ---------------------------------------------------------------------------------------------------------------
   3      SEC USE ONLY

- --------- ---------------------------------------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware

- --------- ---------------------------------------------------------------------------------------------------------------
                   -------- ---------------------------------------------------------------------------------------------
                      5     SOLE VOTING POWER
    Number of
     Shares                 570,000

                   -------- ---------------------------------------------------------------------------------------------
  Beneficially        6     SHARED VOTING POWER
    Owned by
      Each
                            -0-
                   -------- ---------------------------------------------------------------------------------------------
    Reporting         7     SOLE DISPOSITIVE POWER
     Person
      With                  570,000

                   -------- ---------------------------------------------------------------------------------------------
                      8     SHARED DISPOSITIVE POWER

                            -0-

                   -------- ---------------------------------------------------------------------------------------------
- --------- ---------------------------------------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          570,000
- --------- ---------------------------------------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

          N/A
- --------- ---------------------------------------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          4.3%

- --------- ---------------------------------------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          IA

- --------- ---------------------------------------------------------------------------------------------------------------
                                       *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                                 PAGE 5 OF 9 PAGES
</TABLE>


<PAGE>


         The original  statement  shall be signed by each person on whose behalf
the  statement is filed or his  authorized  representative.  If the statement is
signed  on behalf of a person by his  authorized  representative  other  than an
executive  officer or general  partner of the  filing  person,  evidence  of the
representative's  authority to sign on behalf of such person shall be filed with
the  statement,  provided,  however,  that a power of attorney  for this purpose
which is already on file with the Commission may be  incorporated  by reference.
The name and any title of each person who signs the statement  shall be typed or
printed beneath his signature.

Note: Six copies of this statement, including all exhibits, should be filed with
the Commission.

     Attention:  Intentional  misstatements  or  omissions  of  fact  constitute
Federal criminal violations (See 18 U.S.C. 1001)


         Item 1(a)    Name of Issuer:
                      I-STAT

         Item 1(b)    Address of Issuer's Principal Executive Offices:
                      303A College Road East
                      Princeton, NJ   08540

         Item 2(a)    Name of Person Filing:
                      This filing is made on behalf of John Hancock  Mutual Life
                      Insurance   Company    ("JHMLICO"),    JHMLICO's   direct,
                      wholly-owned subsidiary,  John Hancock Subsidiaries,  Inc.
                      ("JHSI"),  JHSI's  direct,  wholly-owned  subsidiary,  The
                      Berkeley Financial Group ("TBFG") and TBFG's  wholly-owned
                      subsidiary, John Hancock Advisers, Inc. ("JHA").

         Item 2(b)    Address of the Principal Offices:
                      The  principal  business  offices of JHMLICO  and JHSI are
                      located at John Hancock Place,  P.O. Box 111,  Boston,  MA
                      02117. The principal  business offices of TBFG and JHA are
                      located at 101 Huntington  Avenue,  Boston,  Massachusetts
                      02199.

         Item 2(c)    Citizenship:
                      JHMLICO and TBFG were  organized  and exist under the laws
                      of the  Commonwealth of  Massachusetts.  JHSI and JHA were
                      organized  and  exist  under  the  laws  of the  State  of
                      Delaware.

         Item 2(d)    Title of Class of Securities:
                      Common Stock

         Item 2(e)    CUSIP Number:
                      450312103

         Item 3       If the Statement is being filed pursuant to Rule 13d-1(b),
                      or 13d-2(b), check whether the person filing is a:
                      

                      JHMLICO: (c) (X) Insurance Company as defined in ss.3(a)
                                       (19) of the Act.

                               (e) (X) Investment  Adviser  registered
                                       under   ss.203  of  the   Investment
                                       Advisers Act of 1940.

                               (g) (X) Parent   Holding   Company,   in
                                       accordance with ss.240.13d-1(b)(ii)(G).


                                            PAGE  6  OF  9  PAGES

<PAGE>


                      JHSI:    (g) (X) Parent Holding Company, in accordance 
                                       with ss.240.13d-1(b)(ii)(G).

                      TBFG:    (g) (X) Parent Holding Company, in accordance 
                                       with ss.240.13d-1(b)(ii)(G).

                      JHA:     (e) (X) Investment Adviser registered under 
                                       ss.203 of the Investment Advisers Act
                                       of 1940.

         Item 4       Ownership:

                      (a)    Amount   Beneficially   Owned:   JHA   has   direct
                             beneficial  ownership  of 570,000  shares of Common
                             Stock. Through their parent-subsidiary relationship
                             to JHA,  JHMLICO,  JHSI  and  TBFG  have  indirect,
                             beneficial ownership of these same shares.

                      (b)    Percent of Class:  4.3%

                      (c) (i) sole power to vote or to direct the vote:  JHA has
                              sole power to vote or direct the direct the vote 
                              of the 570,000 shares of Common Stock under the 
                              Advisory Agreement as follows:

                                                             Date of
                                                Number       Advisory
                           Fund Name            of  Shares   Agreement
                           ---------            ----------   ---------
                      John Hancock Special      
                      Equities Fund             570,000      January 1, 1994

                          (ii)   shared power to vote or to direct the vote: -0-

                          (iii)  sole  power  to  dispose  or to  direct  the
                                 disposition   of:  JHA  has  sole  power  to
                                 dispose or to direct the  disposition of the
                                 570,000  shares  of Common  Stock  under the
                                 Advisory  Agreement  noted  in Item  4(c)(i)
                                 above.

                          (iv)   shared power to dispose or to direct the 
                                 disposition of:     -0-

         Item 5       Ownership of Five Percent or Less of a Class:
                      With this filing,  the  Reporting  Persons state that they
                      own five percent or less of Common Stock.

         Item 6       Ownership of More than Five Percent on Behalf of Another 
                      Person:  See Item 4.

         Item 7       Identification  and  Classification  of the  Subsidiary
                      which  Acquired  the  Security  Being  Reported  on by the
                      Parent Holding Company:
                      See Items 3 and 4 above.

         Item 8       Identification and Classification of Members of the Group:
                      Not applicable.

         Item 9       Notice of Dissolution of a Group:
                      Not applicable.

         Item 10      Certification:
                      By signing below the  undersigned  certifies  that, to the
                      best of its knowledge and belief, the securities  referred
                      to above were acquired in the ordinary  course of business
                      and were not  acquired  for the purpose of and do not have
                      the effect of changing or  influencing  the control of the
                      issuer  of  such  securities  and  were  not  acquired  in
                      connection  with or as a  participant  in any  transaction
                      having such purpose or effect.


                                PAGE 7 OF 9 PAGES


<PAGE>



                                                     SIGNATURE

         After  reasonable  inquiry and to the best of its knowledge and belief,
each of the  undersigned  certifies  that  the  information  set  forth  in this
statement is true, complete and correct.


                                    John Hancock Mutual Life Insurance Company
                                    By:      /s/John T. Farady
                                             -----------------------------------
                                    Name:    John T. Farady
Dated: January 21, 1998             Title:   Senior Vice President & Treasurer


                                    John Hancock Subsidiaries, Inc.
                                    By:      /s/John T. Farady
                                             -----------------------------------
                                    Name:    John T. Farady
Dated: January 21, 1998             Title:   Treasurer



                                    The Berkeley Financial Group
                                    By:      /s/Susan S. Newton
                                             -----------------------------------
                                    Name:    Susan S. Newton
Dated: January 21, 1998             Title:   Vice President


                                    John Hancock Advisers, Inc.
                                    By:      /s/Susan S. Newton
                                             -----------------------------------
                                    Name:    Susan S. Newton
Dated: January 21, 1998             Title:   Vice President


                                                 PAGE 8 OF 9 PAGES


<PAGE>


EXHIBIT A
                                              JOINT FILING AGREEMENT

         John Hancock Mutual Life Insurance Company,  John Hancock Subsidiaries,
Inc., The Berkeley  Financial Group and John Hancock  Advisers,  Inc. agree that
the  terminating  Schedule  13G  (Amendment  No. 2), to which this  Agreement is
attached,  relating to the Common  Stock of I-STAT is filed on behalf of each of
them.


                                    John Hancock Mutual Life Insurance Company
                                    By:      /s/John T. Farady
                                             -----------------------------------
                                    Name:    John T. Farady
Dated: January 21, 1998             Title:   Senior Vice President & Treasurer


                                    John Hancock Subsidiaries, Inc.
                                    By:      /s/John T. Farady
                                             -----------------------------------
                                    Name:    John T. Farady
Dated: January 21, 1998             Title:   Treasurer



                                    The Berkeley Financial Group
                                    By:      /s/Susan S. Newton
                                             -----------------------------------
                                    Name:    Susan S. Newton
Dated: January 21, 1998             Title:   Vice President


                                    John Hancock Advisers, Inc.
                                    By:      /s/Susan S. Newton
                                             -----------------------------------
                                    Name:    Susan S. Newton
Dated: January 21, 1998             Title:   Vice President



                                                 PAGE 9 OF 9 PAGES




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