MATRITECH INC/DE/
S-8, 1996-09-13
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>
 
  As filed with the Securities and Exchange Commission on September 13, 1996.

                                            Registration No. 333-_______

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C.  20549
                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                                MATRITECH, INC.
            (Exact Name of Registrant as Specified in Its Charter)

               DELAWARE                                   04-2985132
(State or Other Jurisdiction of                       (I.R.S. Employer 
Incorporation or Organization)                       Identification No.) 


                               330 NEVADA STREET
                          NEWTON, MASSACHUSETTS 02160
                                (617) 928-0820
              (Address of Principal Executive Offices)  (Zip Code)
                      ____________________________________

                                1992 STOCK PLAN
                           (Full Title of the Plan) 
                      ____________________________________

                                STEPHEN D. CHUBB
                      CHAIRMAN AND CHIEF EXECUTIVE OFFICER
                              330 NEVADA STREET
                          NEWTON,  MASSACHUSETTS 02160
                                 (617) 928-0820
           (Name, Address, Including Zip Code, and Telephone Number,
                  Including Area Code, of Agent for Service)
                      ____________________________________

                                    Copy to:
                              RUFUS C. KING, ESQ.
                        TESTA, HURWITZ & THIBEAULT, LLP
                               HIGH STREET TOWER
                                125 HIGH STREET
                               BOSTON, MA  02110
                                (617) 248-7000

                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
====================================================================================================================================


                                                    Proposed                  Proposed 
Title of Securities     Amount to be                Maximum                   Maximun                  Amount of                   
to be Registered         Registered            Offering Price Per            Aggregate              Registration Fee               
                                                     Share/1              Offering Price 
- ------------------------------------------------------------------------------------------------------------------------------------

<S>                          <C>               <C>                        <C>                      <C>
1992 STOCK PLAN               375,000               $10.438                 $3,914,250                  $1,349.74    
Common Stock, par value                      
 $.01
====================================================================================================================================

</TABLE>

/1/None of such shares are currently subject to outstanding options. Pursuant to
Regulation C, Rule 457(h)(1) under the Securities Act of 1933, as amended, the
price of $10.438 per share, which is the average of the high and low prices of
the Common Stock as reported on the Nasdaq Small-Cap Market on September 9,
1996, is set forth solely for purposes of calculating the filing fee.
<PAGE>
 
      This Registration Statement registers additional securities of the same
class as other securities for which Registration Statement No. 33-50244 on
Form S-8 as filed with the Securities and Exchange Commission (the "SEC") on
July 30, 1992 and Registration Statement No. 33-93198 on Form S-8 as filed with
the SEC on June 6, 1995, relating to the Matritech, Inc. 1992 Stock Plan are
effective. Pursuant to General Instruction E, the contents of the above-listed
Registration Statements are hereby incorporated by reference.


                                    PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
 
Item 8.  Exhibits
- ------   --------
<TABLE> 
<CAPTION>
      Exhibit No.           Description of Exhibits
      ------------          ------------------------
<S>                          <C>
            4.1              1992 Stock Plan of the Registrant, as amended

            5.1              Opinion of Testa, Hurwitz & Thibeault, LLP

           23.1              Consent of Arthur Andersen LLP

           23.2              Consent of Testa, Hurwitz & Thibeault, LLP
                             (included in Exhibit 5.1)

           24.1              Power of Attorney (contained in Pages 2 and 3 of
                             this Registration Statement)
 
</TABLE>
 
Item 9.  Undertakings.
- ------   ------------ 

     The undersigned registrant hereby undertakes:

     (1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:

          (i)    To include any prospectus required by Section 10(a)(3) of the
Securities Act of 1933;

          (ii)   To reflect in the prospectus any facts or events arising after
the effective date of the registration statement (or the most recent post-
effective amendment thereof) which, individually or in the aggregate, represent
a fundamental change in the information set forth in the registration statement.
Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that
which was registered) and any deviation from the low or high and of the
estimated maximum offering range may be reflected in the form of prospectus
filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the
changes in volume and price represent no more than 20 percent change in the
maximum aggregate offering price set forth in the "Calculation of Registration
Fee" table in the effective registration statement;

          (iii)  To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement;

provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
registration statement is on Form S-3, Form S-8 or Form F-3, and the information
required to be included in a post-effective amendment by those paragraphs is
contained in periodic reports filed with or furnished to the Commission by the
registrant pursuant to Section 13 or 15(d) of the Securities Exchange Act of
1934 that are incorporated by reference in the registration statement.

     (2) That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

     (3) To remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the termination of
the offering.

<PAGE>
 
                                   SIGNATURES


    Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Newton, Commonwealth of Massachusetts,
on September 13, 1996.


                                    MATRITECH, INC.


                                    /s/ Stephen D. Chubb
                                    ------------------------------------------
                                    Stephen D. Chubb
                                    Director, Chairman and
                                    Chief Executive Officer



                        POWER OF ATTORNEY AND SIGNATURES

    We, the undersigned officers and directors of Matritech, Inc., hereby
severally constitute and appoint Stephen D. Chubb and Leslie R. Teso, and each
of them singly, our true and lawful attorneys, with full power to them and each
of them singly, to sign for us in our names in the capacities indicated below,
all pre-effective and post-effective amendments to this registration statement,
and generally to do all things in our names and on our behalf in such capacities
to enable Matritech, Inc. to comply with the provisions of the Securities Act of
1933, as amended, and all requirements of the Securities and Exchange
Commission.

Pursuant to the requirements of the Securities Act of 1933, as amended, this
registration statement has been signed by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
 
Signature                                             Title                 Date
- ----------                                         ----------             -------
<S>                                          <C>                       <C>              
 
/s/ Stephen D. Chubb                         Director, Chairman and     September 13, 1996 
- --------------------------------------       Chief Executive Officer,
Stephen D.  Chubb                            (Principal Executive
                                              Officer)
                    
                         
 
/s/ David L.  Corbet                         Director, President and    September 13, 1996 
- --------------------------------------       Chief Operating Officer
David L.  Corbet                             
 

/s/ Leslie R.  Teso                          Vice President, Finance,   September 13, 1996 
- --------------------------------------       Secretary and Treasurer
Leslie R.  Teso                              (Principal Accounting
                                              Officer)
                         
                          
 
 
/s/ J. Robert Buchanan                       Director                   August 27, 1996
- --------------------------------------
J. Robert Buchanan
 
</TABLE> 

<PAGE>
 

<TABLE> 
<CAPTION> 

<S>                                         <C>                        <C> 
/s/ Thomas R.  Morse                         Director                   September 13, 1996
- --------------------------------------
Thomas R.  Morse
 
 
/s/ David Rubinfien                          Director                   September 13, 1996
- --------------------------------------
David Rubinfien
 

T. Stephen Thompson                          Director                   September 13, 1996
- --------------------------------------
T. Stephen Thompson

 
C. William Zadel                             Director                   August 26, 1996
- --------------------------------------
C. William Zadel
</TABLE>

<PAGE>
 
                                 EXHIBIT INDEX
                               -----------------
<TABLE>
<CAPTION>
 
 
        Exhibit No.          Description of Exhibit                           Page
        ------------         -----------------------                          ----
<S>                        <C>                                               <C>
            4.1              1992 Stock Plan of the Registrant, as amended

            5.1              Opinion of Testa, Hurwitz & Thibeault,
                             LLP

           23.1              Consent of Arthur Andersen LLP

           23.2              Consent of Testa, Hurwitz & Thibeault,
                             LLP (included in Exhibit 5.1)

           24.1              Power of Attorney (contained in Pages 2 and
                             3 of this Registration Statement)
 
</TABLE>

<PAGE>
 
                                                                  EXHIBIT 4.1
                                                                  -----------


                                MATRITECH INC.

                                1992 STOCK PLAN
                                ---------------

   1. PURPOSE. This Amended and Restated 1992 Stock Plan (the "Plan") is
      --------   
intended to provide incentives: (a) to the officers and other employees of
Matritech, Inc. (the "Company"), its parent (if any) and any present or future
subsidiaries of the Company (collectively, "Related Corporations") by providing
them with opportunities to purchase stock in the Company pursuant to options
granted hereunder which qualify as "incentive stock options" under Section
422(b) of the Internal Revenue Code of 1986, as amended (the "Code") ("ISO" or
"ISOs"); (b) to directors, officers, employees and consultants of the Company
and Related Corporations by providing them with opportunities to purchase stock
in the Company pursuant to options granted hereunder which do not qualify as
ISOs ("Non-Qualified Option" or "Non-Qualified Options"); (c) to directors,
officers, employees and consultants of the Company and Related Corporations by
providing them with awards of stock in the Company ("Awards"); and (d) to
directors, officers, employees and consultants of the Company and Related
Corporations by providing them with opportunities to make direct purchases of
stock in the Company ("Purchases"). Both ISOs and Non-Qualified Options are
referred to hereafter individually as an "Option" and collectively as "Options".
Options, Awards and authorizations to make Purchases are referred to hereafter
collectively as "Stock Rights". As used herein, the terms "parent" and
"subsidiary" mean "parent corporation" and "subsidiary corporation",
respectively, as those terms are defined in Section 424 of the Code.

   2. ADMINISTRATION OF THE PLAN.
      ---------------------------              

       A.  BOARD OR COMMITTEE ADMINISTRATION. The Plan shall be administered by
           ----------------------------------    
   the Board of Directors of the Company (the "Board") or by a committee
   appointed by the Board (the "Committee"), comprised of, to the extent
   required by applicable regulations under Section 162(m) of the Code, two or
   more outside directors as defined in applicable regulations thereunder and to
   the extent required by Rule 16b-3 promulgated under the Securities Exchange
   Act of 1934 or any successor provision ("Rule 16b-3"), disinterested
   administrators. Hereinafter, all references in this Plan to the "Committee"
   shall mean the Board if no Committee has been appointed. Subject to
   ratification of the grant or authorization of each Stock Right by the Board
   (if so required by applicable state law), and subject to the terms of the
   Plan, the Committee shall have the authority to (i) determine the employees
   of the Company and Related Corporations (from among the class of employees
   eligible under paragraph 3 to receive ISOs) to whom ISOs may be granted, and
   to determine (from among the class of individuals and entities eligible under
   paragraph 3 to receive Non-Qualified Options and Awards and to make
   Purchases) to whom Non-Qualified Options, Awards and authorizations to make
   Purchases may be granted; (ii) determine the time or times at which Options
   or Awards may be granted or Purchases made; (iii) determine the option price
   of shares subject to each Option, which price shall not be less than the
   minimum price specified in paragraph 6, and the purchase price of shares
   subject to each Purchase; (iv) determine whether each Option granted shall be
   an ISO or a Non-Qualified Option; (v) determine (subject to paragraph 7) the
   time or times when each Option shall become exercisable and the duration of
   the exercise period; (vi) determine whether restrictions such as repurchase
   options are to be imposed on shares
<PAGE>
 
   subject to Options, Awards and Purchases and the nature of such restrictions,
   if any, and (vii) interpret the Plan and prescribe and rescind rules and
   regulations relating to it. If the Committee determines to issue a Non-
   Qualified Option, it shall take whatever actions it deems necessary, under
   Section 422 of the Code and the regulations promulgated thereunder, to ensure
   that such Option is not treated as an ISO. The interpretation and
   construction by the Committee of any provisions of the Plan or of any Stock
   Right granted under it shall be final unless otherwise determined by the
   Board. The Committee may from time to time adopt such rules and regulations
   for carrying out the Plan as it may deem best. No member of the Board or the
   Committee shall be liable for any action or determination made in good faith
   with respect to the Plan or any Stock Right granted under it.

       B.  COMMITTEE ACTIONS.  The Committee may select one of its members
           -----------------                                             
   as its chairman, and shall hold meetings at such times and places as it may
   determine. Acts by a majority of the Committee, or acts reduced to or
   approved in writing by a majority of the members of the Committee (if
   consistent with applicable state law), shall be the valid acts of the
   Committee. From time to time the Board may increase the size of the Committee
   and appoint additional members thereof, remove members (with or without
   cause) and appoint new members in substitution therefor, fill vacancies
   however caused, or remove all members of the Committee and thereafter
   directly administer the Plan.

       C.  GRANT OF STOCK RIGHTS TO BOARD MEMBERS.  Stock Rights may be granted
           --------------------------------------                      
   to members of the Board consistent with the provisions of the first sentence
   of paragraph 2(A) above, if applicable. All grants of Stock Rights to members
   of the Board shall in all other respects be made in accordance with the
   provisions of this Plan applicable to other eligible persons. Consistent with
   the provisions of the first sentence of paragraph 2(A) above, members of the
   Board who are either (i) eligible for Stock Rights pursuant to the Plan or
   (ii) have been granted Stock Rights may vote on any matters affecting the
   administration of the Plan or the grant of any Stock Rights pursuant to the
   Plan, except that no such member shall act upon the granting to himself of
   Stock Rights, but any such member may be counted in determining the existence
   of a quorum at any meeting of the Board during which action is taken with
   respect to the granting to him of Stock Rights.

   3.  ELIGIBLE EMPLOYEES AND OTHERS.  ISOs may be granted to any employee of
              -----------------------------                                    
the Company or any Related Corporation. Those officers and directors of the
Company who are not employees may not be granted ISOs under the Plan. Non-
Qualified Options, Awards and authorizations to make Purchases may be granted to
any employee, officer or director (whether or not also an employee) or
consultant of the Company or any Related Corporation. The Committee may take
into consideration a recipient's individual circumstances in determining whether
to grant an ISO, a Non-Qualified Option, an Award or an authorization to make a
Purchase. Granting of any Stock Right to any individual or entity shall neither
entitle that individual or entity to, nor disqualify him from, participation in
any other grant of Stock Rights.

   4.  STOCK.  The stock subject to Options, Awards and Purchases shall be
       -----                                                         
authorized but unissued shares of Common Stock of the Company, par value $.01
per share (the "Common Stock"), or shares of Common Stock reacquired by the
Company in any manner. The aggregate number of shares which may be issued
pursuant to the Plan is 1,000,000, subject to adjustment as provided in
paragraph 13; provided, however, that such number of shares shall not be subject
              --------  -------
to adjustment by reason of the 9.1 for one stock split in the form of a stock
dividend declared by the Board of Directors of the Company at a meeting on March
2, 1992. Any such shares may be issued as ISOs, Non-Qualified Options or Awards,
or to persons
<PAGE>
 
or entities making Purchases, so long as the number of shares so issued does not
exceed such number, as adjusted. If any Stock Right granted under the Plan shall
expire or terminate for any reason without having been exercised in full or
shall cease for any reason to be exercisable in whole or in part, the unissued
shares subject to such Stock Options shall again be available for grants of
Stock Rights under the Plan. For the purposes of the foregoing sentence, shares
withheld from the Stock Right exercise to pay the exercise price and/or tax
consequences of the exercise shall be deemed to have been issued.

   No employee of the Company or any Related Corporation may be granted Options
to acquire, in the aggregate, more than 300,000 shares of Common Stock under the
Plan.  If any Option granted under the Plan shall expire or terminate for any
reason without having been exercised in full or shall cease for any reason to be
exercisable in whole or in part, the unpurchased shares subject to such Option
shall be included in the determination of the aggregate number of shares of
Common Stock deemed to have been granted to such employee under the Plan.

   5.  GRANTING OF STOCK RIGHTS.  Stock Rights may be granted under the Plan
       ------------------------                                    
at any time after the effective date of the Company's initial public offering,
and prior to March 2, 2002. The date of grant of a Stock Right under the Plan
will be the date specified by the Committee at the time it grants the Stock
Right; provided, however, that such date shall not be prior to the date on which
the Committee acts to approve the grant. The Committee shall have the right,
with the consent of the optionee, to convert an ISO granted under the Plan to a
Non-Qualified Option pursuant to paragraph 16.

   6.  MINIMUM OPTION PRICE; ISO LIMITATIONS.  
       -------------------------------------                 

       A.  PRICE FOR NON-QUALIFIED OPTIONS, AWARDS AND PURCHASES. The exercise
           -----------------------------------------------------         
   price per share specified in the agreement relating to each Non-Qualified
   Option granted, and the purchase price per share of stock granted in any
   Award or authorized as a Purchase, under the Plan shall in no event be less
   than the minimum legal consideration required therefor under the laws of
   Delaware or the laws of any jurisdiction in which the Company or its
   successors in interest may be organized.

       B.  PRICE FOR ISOS.  The exercise price per share specified in the
           --------------                                             
   the agreement relating to each ISO granted under the Plan shall not be less
   than the fair market value per share of Common Stock on the date of such
   grant. In the case of an ISO to be granted to an employee owning stock
   possessing more than ten percent (10%) of the total combined voting power of
   all classes of stock of the Company or any Related Corporation, the price per
   share specified in the agreement relating to such ISO shall not be less than
   one hundred ten percent (110%) of the fair market value per share of Common
   Stock on the date of grant.

       C.  $100,000 ANNUAL LIMITATION ON ISOS.  Each eligible employee may
           ----------------------------------                     
   be granted ISOs only to the extent that, in the aggregate under this Plan and
   all incentive stock option plans of the Company and any Related Corporation,
   such ISOs do not become exercisable for the first time by such employee
   during any calendar year in a manner which would entitle the employee to
   purchase more than $100,000 in fair market value (determined at the time the
   ISOs were granted) of Common Stock in that year. Any options granted to an
   employee in excess of such amount will be granted as Non-Qualified Options.

       D.  DETERMINATION OF FAIR MARKET VALUE.  If, at the time an Option
           ----------------------------------                           
   is granted under the Plan, the Company's Common Stock is publicly traded,
   "fair market value" shall be determined as of the last business day for which
   the prices or quotes discussed in this sentence are available prior to the
   date such Option is granted and shall mean (i) the average (on that date) of
   the high and low
<PAGE>
 
   prices of the Common Stock on the principal national securities exchange on
   which the Common Stock is traded, if the Common Stock is then traded on a
   national securities exchange; or (ii) the last reported sale price (on that
   date) of the Common Stock on the NASDAQ National Market List, if the Common
   Stock is not then traded on a national securities exchange; or (iii) the
   closing bid price (or average of bid prices) last quoted (on that date) by an
   established quotation service for over-the-counter securities, if the Common
   Stock is not reported on the NASDAQ National Market List. However, if the
   Common Stock is not publicly traded at the time an Option is granted under
   the Plan, "fair market value" shall be deemed to be the fair value of the
   Common Stock as determined by the Committee after taking into consideration
   all factors which it deems appropriate, including, without limitation, recent
   sale and offer prices of the Common Stock in private transactions negotiated
   at arm's length.

   7.  OPTION DURATION.  Subject to earlier termination as provided in
       ---------------                                                  
paragraphs 9 and 10, each Option shall expire on the date specified by the
Committee, but not more than (i) ten years and one day from the date of grant in
the case of Non-Qualified Options, (ii) ten years from the date of grant in the
case of ISOs generally, and (iii) five years from the date of grant in the case
of ISOs granted to an employee owning stock possessing more than ten percent
(10%) of the total combined voting power of all classes of stock of the Company
or any Related Corporation. Subject to earlier termination as provided in
paragraphs 9 and 10, the term of each ISO shall be the term set forth in the
original instrument granting such ISO, except with respect to any part of such
ISO that is converted into a Non-Qualified Option pursuant to paragraph 16.

   8.  EXERCISE OF OPTION.  Subject to the provisions of paragraphs 9
       ------------------                                             
through 12, each Option granted under the Plan shall be exercisable as follows:

       A.  VESTING.  The Option shall either be fully exercisable on the
           -------                                                 
   date of grant or shall become exercisable thereafter in such installments as
   the Committee may specify.

       B.  FULL VESTING OF INSTALLMENTS.  Once an installment becomes 
           ----------------------------                        
   exercisable it shall remain exercisable until expiration or termination of
   the Option, unless otherwise specified by the Committee.

       C.  PARTIAL EXERCISE.  Each Option or installment may be exercised
           ----------------                                           
   at any time or from time to time, in whole or in part, for up to the total
   number of shares with respect to which it is then exercisable.

       D.  ACCELERATION OF VESTING.  The Committee shall have the right to
           -----------------------                                    
   accelerate the date of exercise of any installment of any Option; provided
   that the Committee shall not, without the consent of an optionee, accelerate
   the exercise date of any installment of any Option granted to any employee as
   an ISO (and not previously converted into a Non-Qualified Option pursuant to
   paragraph 16) if such acceleration would violate the annual vesting
   limitation contained in Section 422(d) of the Code, as described in paragraph
   6(C).

   9.  TERMINATION OF EMPLOYMENT.  If an ISO optionee ceases to be employed
       -------------------------                                                
by the Company and all Related Corporations other than by reason of death or
disability as defined in paragraph 10, no further installments of his ISOs shall
become exercisable, and his ISOs shall terminate after the passage of ninety
(90) days from the date of termination of his employment, but in no event later
than on their specified expiration dates, except to the extent that such ISOs
(or unexercised installments thereof) have been converted into Non-Qualified
Options pursuant to paragraph 16. Employment shall be considered
<PAGE>
 
as continuing uninterrupted during any bona fide leave of absence (such as those
attributable to illness, military obligations or governmental service) provided
that the period of such leave does not exceed 90 days or, if longer, any period
during which such optionee's right to reemployment is guaranteed by statute. A
bona fide leave of absence with the written approval of the Committee shall not
be considered an interruption of employment under the Plan, provided that such
written approval contractually obligates the Company or any Related Corporation
to continue the employment of the optionee after the approved period of absence.
ISOs granted under the Plan shall not be affected by any change of employment
within or among the Company and Related Corporations, so long as the optionee
continues to be an employee of the Company or any Related Corporation. Nothing
in the Plan shall be deemed to give any grantee of any Stock Right the right to
be retained in employment or other service by the Company or any Related
Corporation for any period of time.

   10.  DEATH; DISABILITY.  
        -----------------                 

       A.  DEATH.  If an ISO optionee ceases to be employed by the Company
           -----                                                         
   and all Related Corporations by reason of his death, any ISO of his may be
   exercised, to the extent of the number of shares with respect to which he
   could have exercised it on the date of his death, by his estate, personal
   representative or beneficiary who has acquired the ISO by will or by the laws
   of descent and distribution, at any time prior to the earlier of the
   specified expiration date of the ISO or 180 days from the date of the
   optionee's death.

       B.  DISABILITY.  If an ISO optionee ceases to be employed by the Company
           ----------                                                
   and all Related Corporations by reason of his disability, he shall have the
   right to exercise any ISO held by him on the date of termination of
   employment, to the extent of the number of shares with respect to which he
   could have exercised it on that date, at any time prior to the earlier of the
   specified expiration date of the ISO or 180 days from the date of the
   termination of the optionee's employment. For the purposes of the Plan, the
   term "disability" shall mean "permanent and total disability" as defined in
   Section 22(e)(3) of the Code or successor statute.

   11.  ASSIGNABILITY.  No Option shall be assignable or transferable by the
        -------------                                                 
the optionee except by will or by the laws of descent and distribution. During
the lifetime of the optionee each Option shall be exercisable only by him.

   12.  TERMS AND CONDITIONS OF OPTIONS.  Options shall be evidenced by
        -------------------------------                                 
instruments (which need not be identical) in such forms as the Committee may
from time to time approve. Such instruments shall conform to the terms and
conditions set forth in paragraphs 6 through 11 hereof and may contain such
other provisions as the Committee deems advisable which are not inconsistent
with the Plan, including restrictions applicable to shares of Common Stock
issuable upon exercise of Options. In granting any Non-Qualified Option, the
Committee may specify that such Non-Qualified Option shall be subject to the
restrictions set forth herein with respect to ISOs, or to such other termination
and cancellation provisions as the Committee may determine. The Committee may
from time to time confer authority and responsibility on one or more of its own
members and/or one or more officers of the Company to execute and deliver such
instruments. The proper officers of the Company are authorized and directed to
take any and all action necessary or advisable from time to time to carry out
the terms of such instruments.

   13.  ADJUSTMENTS.  Upon the occurrence of any of the following events,
        -----------                                                  
an optionee's rights with respect to Options granted to him hereunder shall be
adjusted as hereinafter provided, unless otherwise specifically provided in the
written agreement between the optionee and the Company relating to such Option:
<PAGE>
 
       A.  STOCK DIVIDENDS AND STOCK SPLITS.  If the shares of Common Stock
           --------------------------------                              
   shall be subdivided or combined into a greater or smaller number of shares or
   if the Company shall issue any shares of Common Stock as a stock dividend on
   its outstanding Common Stock, the number of shares of Common Stock
   deliverable upon the exercise of Options shall be appropriately increased or
   decreased proportionately, and appropriate adjustments shall be made in the
   purchase price per share to reflect such subdivision, combination or stock
   dividend.

       B.  CONSOLIDATIONS OR MERGERS.  If the Company is to be consolidated
           -------------------------                                     
   with or acquired by another entity in a merger, sale of all or substantially
   all of the Company's assets or otherwise (an "Acquisition"), the Committee or
   the board of directors of any entity assuming the obligations of the Company
   hereunder (the "Successor Board"), shall, as to outstanding Options, either
   (i) make appropriate provision for the continuation of such Options by
   substituting on an equitable basis for the shares then subject to such
   Options the consideration payable with respect to the outstanding shares of
   Common Stock in connection with the Acquisition; or (ii) upon written notice
   to the optionees, provide that all Options must be exercised, to the extent
   then exercisable, within a specified number of days of the date of such
   notice, at the end of which period the Options shall terminate; or (iii)
   terminate all Options in exchange for a cash payment equal to the excess of
   the fair market value of the shares subject to such Options (to the extent
   then exercisable) over the exercise price thereof.

       C.  RECAPITALIZATION OR REORGANIZATION.  In the event of a
           ----------------------------------                       
  recapitalization or reorganization of the Company (other than a transaction
   described in subparagraph B above) pursuant to which securities of the
   Company or of another corporation are issued with respect to the outstanding
   shares of Common Stock, an optionee upon exercising an Option shall be
   entitled to receive for the purchase price paid upon such exercise the
   securities he would have received if he had exercised his Option prior to
   such recapitalization or reorganization.

       D.  MODIFICATION OF ISOS.  Notwithstanding the foregoing, any 
           --------------------                                    
   adjustments made pursuant to subparagraphs A, B or C with respect to ISOs
   shall be made only after the Committee, after consulting with counsel for the
   Company, determines whether such adjustments would constitute a
   "modification" of such ISOs (as that term is defined in Section 424 of the
   Code) or would cause any adverse tax consequences for the holders of such
   ISOs. If the Committee determines that such adjustments made with respect to
   ISOs would constitute a modification of such ISOs, it may refrain from making
   such adjustments.

       E.  DISSOLUTION OR LIQUIDATION.  In the event of the proposed
           --------------------------                                    
   dissolution or liquidation of the Company, each Option will terminate
   immediately prior to the consummation of such proposed action or at such
   other time and subject to such other conditions as shall be determined by the
   Committee.

       F.  ISSUANCES OF SECURITIES.  Except as expressly provided herein,
           -----------------------                                    
   no issuance by the Company of shares of stock of any class, or securities
   convertible into shares of stock of any class, shall affect, and no
   adjustment by reason thereof shall be made with respect to, the number or
   price of shares subject to Options. No adjustments shall be made for
   dividends paid in cash or in property other than securities of the Company.

       G.  FRACTIONAL SHARES.  No fractional shares shall be issued under
           -----------------                                           
   the Plan and the optionee shall receive from the Company cash in lieu of such
   fractional shares.
<PAGE>
 
       H.  ADJUSTMENTS.  Upon the happening of any of the events described
           -----------                                                 
   in subparagraphs A, B or C above, the class and aggregate number of shares
   set forth in paragraph 4 hereof that are subject to Stock Rights which
   previously have been or subsequently may be granted under the Plan shall also
   be appropriately adjusted to reflect the events described in such
   subparagraphs. The Committee or the Successor Board shall determine the
   specific adjustments to be made under this paragraph 13 and, subject to
   paragraph 2, its determination shall be conclusive.

   If any person or entity owning restricted Common Stock obtained by exercise
of a Stock Right made hereunder receives shares or securities or cash in
connection with a corporate transaction described in subparagraphs A, B or C
above as a result of owning such restricted Common Stock, such shares or
securities or cash shall be subject to all of the conditions and restrictions
applicable to the restricted Common Stock with respect to which such shares or
securities or cash were issued, unless otherwise determined by the Committee or
the Successor Board.

   14.  MEANS OF EXERCISING STOCK RIGHTS.  A Stock Right (or any part or
        --------------------------------                              
installment thereof) shall be exercised by giving written notice to the Company
at its principal office address. Such notice shall identify the Stock Right
being exercised and specify the number of shares as to which such Stock Right is
being exercised, accompanied by full payment of the purchase price therefor (a)
in United States dollars in cash or by check, (b) at the discretion of the
Committee, through delivery or withholding from the Stock Right exercise of
shares of Common Stock having a fair market value equal as of the date of the
exercise to the cash exercise price of the Stock Right, (c) at the discretion of
the Committee, by delivery of the grantee's personal recourse note bearing
interest payable not less than annually at no less than 100% of the lowest
applicable Federal rate, as defined in Section 1274(d) of the Code, (d) at the
discretion of the Committee and consistent with applicable law, through the
delivery of an assignment to the Company of a sufficient amount of the proceeds
from the sale of the Common Stock acquired upon exercise of the Stock Right and
an authorization to the broker or selling agent to pay that amount to the
Company, which sale shall be at the participant's direction at the time of
exercise, or (e) at the discretion of the Committee, by any combination of (a),
(b), (c) and (d) above. If the Committee exercises its discretion to permit
payment of the exercise price of an ISO by means of the methods set forth in
clauses (b), (c), (d) or (e) of the preceding sentence, such discretion shall be
exercised in writing at the time of the grant of the ISO in question. The holder
of a Stock Right shall not have the rights of a shareholder with respect to the
shares covered by his Stock Right until the date of issuance of a stock
certificate to him for such shares. Except as expressly provided above in
paragraph 13 with respect to changes in capitalization and stock dividends, no
adjustment shall be made for dividends or similar rights for which the record
date is before the date such stock certificate is issued.

   15.  TERM AND AMENDMENT OF PLAN.  This Plan was adopted by the Board of
        --------------------------                                      
Directors and Stockholders of the Company on March 2, 1992. The Plan shall
expire at the end of the day on March 2, 2002 (except as to Options outstanding
on that date). The Board may terminate or amend the Plan in any respect at any
time, except that, without the approval of the stockholders obtained within 12
months before or after the Board adopts a resolution authorizing any of the
following actions: (a) the total number of shares that may be issued under the
Plan may not be increased materially (except by adjustment pursuant to paragraph
13); (b) the benefits accruing to participants under the Plan may not be
materially increased; (c) the requirements as to eligibility for participation
in the Plan may not be materially modified; (d) the provisions of paragraph 3
regarding eligibility for grants of ISOs may not be modified; (e) the provisions
of paragraph 6(B) regarding the exercise price at which shares may be offered
pursuant to ISOs may not be modified (except by adjustment pursuant to paragraph
13); (f) the expiration date of the Plan may not be extended; and (g) the Board
may not take any action which would
<PAGE>
 
cause the Plan to fail to comply with Rule 16b-3. Except as otherwise provided
in this paragraph 15, in no event may action of the Board or stockholders alter
or impair the rights of a grantee, without his consent, under any Stock Right
previously granted to him.

   16.   CONVERSION OF ISOS INTO NON-QUALIFIED OPTIONS; TERMINATION OF ISOS.
         ------------------------------------------------------------------
The Committee, at the written request of any optionee, may in its discretion
take such actions as may be necessary to convert such optionee's ISOs (or any
installments or portions of installments thereof) that have not been exercised
on the date of conversion into Non-Qualified Options at any time prior to the
expiration of such ISOs, regardless of whether the optionee is an employee of
the Company or a Related Corporation at the time of such conversion. Such
actions may include, but not be limited to, extending the exercise period or
reducing the exercise price of the appropriate installments of such ISOs. At the
time of such conversion, the Committee (with the consent of the optionee) may
impose such conditions on the exercise of the resulting Non-Qualified Options as
the Committee in its discretion may determine, provided that such conditions
shall not be inconsistent with this Plan. Nothing in the Plan shall be deemed to
give any optionee the right to have such optionee's ISOs converted into Non-
Qualified Options, and no such conversion shall occur until and unless the
Committee takes appropriate action. The Committee, with the consent of the
optionee, may also terminate any portion of any ISO that has not been exercised
at the time of such termination.

   17.  APPLICATION OF FUNDS.  The proceeds received by the Company from
        --------------------                                             
the sale of shares pursuant to Options granted and Purchases authorized under
the Plan shall be used for general corporate purposes.

   18.  GOVERNMENTAL REGULATION.  The Company's obligation to sell and
        -----------------------                                         
deliver shares of the Common Stock under this Plan is subject to the approval of
any governmental authority required in connection with the authorization,
issuance or sale of such shares.

   19.  WITHHOLDING OF ADDITIONAL INCOME TAXES.  Upon the exercise of a
        --------------------------------------                         
Non-Qualified Option, the grant of an Award, the making of a Purchase of Common
Stock for less than its fair market value, the making of a Disqualifying
Disposition (as defined in paragraph 20) or the vesting of restricted Common
Stock acquired on the exercise of a Stock Right hereunder, the Company, in
accordance with Section 3402(a) of the Code, may require the optionee, Award
recipient or purchaser to pay additional withholding taxes in respect of the
amount that is considered compensation includible in such person's gross income.
The Committee in its discretion may condition (i) the exercise of an Option,
(ii) the grant of an Award, (iii) the making of a Purchase of Common Stock for
less than its fair market value, or (iv) the vesting of restricted Common Stock
acquired by exercising a Stock Right, on the grantee's payment of such
additional withholding taxes. Payment of such additional withholding taxes shall
be in United States dollars in cash or by check and/or at the discretion of the
Committee, through the delivery of previously held shares of common stock or
withholding from the Stock Right exercise of shares of Common Stock having a
fair market value equal as of the date of exercise to the amount of such
withholding taxes.

   20.  NOTICE TO COMPANY OF DISQUALIFYING DISPOSITION. Each employee who
        ----------------------------------------------         
receives an ISO must agree to notify the Company in writing immediately after
the employee makes a Disqualifying Disposition of any Common Stock acquired
pursuant to the exercise of an ISO. A Disqualifying Disposition is any
disposition (including any sale) of such Common Stock before the later of (a)
two years after the date the employee was granted the ISO, or (b) one year after
the date the employee acquired Common Stock by exercising the ISO. If the
employee has died before such stock is sold, these holding period requirements
do not apply and no Disqualifying Disposition can occur thereafter.
<PAGE>
 
   21.  GOVERNING LAW; CONSTRUCTION.  The validity and construction of the
        ---------------------------                                 
Plan and the instruments evidencing Stock Rights shall be governed by the laws
of the State of Delaware, or the laws of any jurisdiction in which the Company
or its successors in interest may be organized. In construing this Plan, the
singular shall include the plural and the masculine gender shall include the
feminine and neuter, unless the context otherwise requires.

<PAGE>
 
                                                                     EXHIBIT 5.1
                                                                     -----------
                               September 13, 1996


Matritech, Inc.
330 Nevada Street
Newton, MA  02160

     Re:  Registration Statement on Form S-8 Relating to the
          1992 Stock Plan of Matritech, Inc. (hereinafter the "Plan")
          ----------------------------------------------------------

Ladies and Gentlemen:

     Reference is made to the above-captioned Registration Statement on Form S-8
(the "Registration Statement") filed by Matritech, Inc. (the "Company") on the
date hereof with the Securities and Exchange Commission under the Securities Act
of 1933, as amended, relating to an aggregate of 375,000 shares of Common
Stock, $.01 par value, of the Company issued or issuable pursuant to the Plan
(the "Shares").

     We have examined, and are familiar with, and have relied as to factual
matters solely upon, copies of the Plan, the Certificate of Incorporation and
By-laws of the Company, the minute books and stock records of the Company and
originals of such other documents, certificates and proceedings as we have
deemed necessary for the purpose of rendering this opinion.

     Based on the foregoing, we are of the opinion that the Shares have been
duly authorized and, when issued and sold in accordance with the Plan, will be
validly issued, fully paid and nonassessable.

     We hereby consent to filing of this opinion as Exhibit 5.1 to the
Registration Statement.

                                    Very truly yours,

                                    /s/ Testa, Hurwitz & Thibeault, LLP

                                    TESTA, HURWITZ & THIBEAULT, LLP

<PAGE>
 
                                                                    EXHIBIT 23.1
                                                                    ------------





                   CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


          As independent public accountants, we hereby consent to the use of our
report (and to all references to our Firm) included in or made a part of this
Registration Statement.


                                    /s/ Arthur Andersen LLP
                                    
                                    ARTHUR ANDERSEN LLP


Boston, Massachusetts
September 9, 1996


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