MATRITECH INC/DE/
8-K, 1999-11-22
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                                    FORM 8-K


                                 CURRENT REPORT


                       PURSUANT TO SECTION 13 OR 15(d) OF
                       THE SECURITIES EXCHANGE ACT OF 1934


       Date of report (Date of earliest event reported): NOVEMBER 22, 1999
                                                         -----------------


                                 MATRITECH, INC.
             ------------------------------------------------------
             (Exact Name of Registrant as Specified in Its Charter)


                                    DELAWARE
                 ----------------------------------------------
                 (State or Other Jurisdiction of Incorporation)


            0-12128                                   04-2985132
     ------------------------             ---------------------------------
     (Commission File Number)             (IRS Employer Identification No.)


               330 NEVADA STREET, NEWTON, MASSACHUSETTS 02460 USA
               ---------------------------------------------------
               (Address of Principal Executive Offices) (Zip Code)


               Registrant's telephone number, including area code:


                                 (617) 928-0820
                                 --------------


<PAGE>   2


ITEM 5.   OTHER EVENTS.

     PRIVATE PLACEMENT
     -----------------

     On November 22, 1999, the Registrant completed a private placement of
900,670 units, with each unit consisting of two shares of Common Stock and a
warrant to purchase one share of Common Stock for an aggregate selling price of
$3,602,680. The Registrant will receive net proceeds of approximately $3,523,000
after deducting the estimated expenses of the transaction. The warrants issued
in this transaction may be exercised at a price of $2.20 per share for two years
and are callable by Matritech if certain Common Stock price levels are reached
during the two-year period.

     These securities were offered and sold only to "accredited investors" (as
defined in Regulation D).

     In connection with the transaction, the Registrant agreed to file, within
60 days of November 22, 1999, a registration statement with the Securities and
Exchange Commission covering the resale from time to time of the shares of
Common Stock issued in connection with the private placement and the shares of
Common Stock issuable upon exercise of the warrants issued in connection with
the private placement and to use its best efforts to cause the registration
statement to become effective.

ITEM 7.   FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS

(a) Financial Statements
- ------------------------

     The effects of the private placement financing described in Item 5 are
reflected in the following actual and pro forma unaudited balance sheet
information of the Registrant as of September 30, 1999.


                                 MATRITECH, INC.
                                 BALANCE SHEETS
                                     ASSETS

<TABLE>
<CAPTION>
                                                                   PRO FORMA
                                                SEPTEMBER 30,     SEPTEMBER 30,
                                                   1999              1999(1)
                                                -------------     -------------
<S>                                             <C>                <C>
CURRENT ASSETS:
  Cash and cash equivalents                     $3,509,134         $7,031,814
  Accounts receivable, net                         154,500            154,500
  Inventories                                      338,905            338,905
  Prepaid expenses                                  56,780             56,780
                                                ----------         ----------
        Total current assets                     4,059,319          7,581,999
                                                ----------         ----------

PROPERTY AND EQUIPMENT, at cost:
  Laboratory equipment                           1,440,920          1,440,920
  Office equipment                                 217,150            217,150
  Laboratory furniture                              62,739             62,739
  Leasehold improvements                            56,981             56,981
                                                ----------         ----------
                                                 1,777,790          1,777,790

       Less-Accumulated depreciation
              and amortization                   1,201,182          1,201,182
                                                ----------         ----------
                                                   576,608            576,608
                                                ----------         ----------


OTHER ASSETS, net                                   65,696             65,696
                                                ----------         ----------
                                                $4,701,623         $8,224,303
                                                ==========         ==========
</TABLE>





                                 MATRITECH, INC.
                                 BALANCE SHEETS
                      LIABILITIES AND STOCKHOLDERS' EQUITY


<TABLE>
<CAPTION>
                                                                         PRO FORMA
                                                    SEPTEMBER 30,       SEPTEMBER 30,
                                                        1999               1999(1)
                                                    -------------       ------------
<S>                                                 <C>                 <C>
CURRENT LIABILITIES:
    Current maturities of note payable              $     59,521        $     59,521
    Accounts payable                                     213,062             213,062
    Accrued expenses                                     700,792             700,792
                                                    ------------        ------------
         Total current liabilities                       973,375             973,375
                                                    ------------        ------------

NOTE PAYABLE, LESS CURRENT
 MATURITIES                                               98,794              98,794
                                                    ------------        ------------

STOCKHOLDERS' EQUITY:
 Preferred stock, $1.00 par value -
   Authorized - 4,000,000 shares
   Issued and outstanding - none                              --                  --
 Common stock, $.01 par value -
   Authorized - 40,000,000 shares
   Issued and outstanding -
     21,724,217 shares at
     September 30, 1999 and
     23,525,557 shares at
     pro forma September
     30, 1999                                            217,242             235,255
   Additional paid-in capital                         49,247,706          52,752,373
   Accumulated deficit                               (45,835,494)        (45,835,494)
                                                    ------------        ------------
            Total stockholders' equity                 3,629,454           7,152,134
                                                    ------------        ------------
                                                    $  4,701,623        $  8,224,303
                                                    ============        ============
</TABLE>
- ----------------------

(1)  This pro forma unaudited balance sheet information should be read in
     conjunction with the Registrant's unaudited financial statements and notes
     thereto contained in its Quarterly Report on Form 10-Q for the three-month
     period ended September 30, 1999. This pro forma unaudited balance sheet
     information reflects the sale of 900,670 units, each unit consisting of two
     shares of the Company's Common Stock and a warrant to purchase one share of
     the Company's Common Stock, at $4.00 per unit after deducting $80,000 in
     estimated offering expenses.

     This pro forma unaudited balance sheet information is not necessarily
     indicative of what the Registrant's financial position would have been had
     such transaction in fact occurred on September 30, 1999.

(c)  Exhibits
- -------------

4.1  Form of Common Stock and Warrant Purchase Agreement between Matritech, Inc.
     and the several investors.

4.2  Form of Warrant Agreement issued by Matritech, Inc. to the several
     investors.


                                       2
<PAGE>   3

                                   SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.




                                             MATRITECH, INC.


November 22, 1999                            By: /s/ Stephen D. Chubb
                                                 -------------------------------
                                                 Name:  Stephen D. Chubb
                                                 Title: Chairman, Director and
                                                        Chief Executive Officer


                                       3
<PAGE>   4

                                  EXHIBIT INDEX

EXHIBIT NUMBER    DESCRIPTION

4.1               Form of Common Stock and Warrant Purchase Agreement between
                  Matritech, Inc. and the several investors.

4.2               Form of Warrant Agreement issued by Matritech, Inc. to the
                  several investors.


                                       4

<PAGE>   1
                                                                     EXHIBIT 4.1

                   COMMON STOCK AND WARRANT PURCHASE AGREEMENT

                          DATED AS OF NOVEMBER __, 1999

                                     BETWEEN

                                 MATRITECH, INC.

                                       AND

                        THE PURCHASER LISTED ON EXHIBIT A

                   COMMON STOCK AND WARRANT PURCHASE AGREEMENT

     THIS COMMON STOCK AND WARRANT PURCHASE AGREEMENT ("Agreement") is entered
into as of this ____ day of November, 1999 between Matritech, Inc., a Delaware
corporation ("Matritech"), and _____________________________ (the "Purchaser").

                                    SECTION 1

                        SALE OF COMMON STOCK AND WARRANTS

     1.1  SALE OF COMMON STOCK AND WARRANTS. Subject to the terms and conditions
hereof, Matritech will issue and sell to the Purchaser, and the Purchaser will
purchase from Matritech, at the Closing (as defined below) the number of Units
set forth opposite the Purchaser's name on EXHIBIT A. A "Unit" shall be composed
of two shares ("Shares") of common stock, $0.01 par value, of Matritech ("Common
Stock") and a warrant to purchase one share of Common Stock ("Warrant Share"). A
form of the warrant is attached as EXHIBIT B ("Warrant"). The purchase price per
Unit ("Unit Purchase Price") shall be equal to $4.00. The exercise price per
Warrant Share shall be equal to $2.20.

     1.2  CLOSING DATE. The closing of the purchase and sale of the Units
("Closing") shall be held at the offices of Testa, Hurwitz & Thibeault, LLP, 125
High Street, Boston, Massachusetts on November 22, 1999, or at such other time
and place upon which Matritech and the Purchaser shall mutually agree (the date
of the Closing is hereinafter referred to as the "Closing Date").

     1.3  DELIVERY. At the Closing, Matritech will (i) deliver to Purchaser the
Warrants purchased by Purchaser, and (ii) instruct its transfer agent to deliver
to Purchaser as soon as is reasonably practicable certificates representing the
Shares purchased by Purchaser, against payment of the aggregate Unit Purchase
Price therefor, by wire transfer to Matritech or certified or cashier's check
drawn on a United States bank made to the order of Matritech.

     1.4  REPLACEMENT OF CERTIFICATES. Upon receipt of evidence reasonably
satisfactory to Matritech of the loss, theft, destruction or mutilation of any
Shares or Warrant


<PAGE>   2


                                      -2-


Shares, and in the case of any such loss, theft or destruction of any Shares or
Warrant Shares, on delivery of an indemnity agreement or security reasonably
satisfactory in form and amount to Matritech or, in the case of any such
mutilation, on surrender and cancellation of such Shares or Warrant Shares,
Matritech at its expense will execute and deliver in lieu thereof, new
certificates of like tenor and amount.

                                    SECTION 2

                   REPRESENTATIONS AND WARRANTIES OF MATRITECH

     Matritech hereby represents and warrants to Purchaser as of the Closing
Date that, except as otherwise disclosed in Matritech's filings to the U.S.
Securities and Exchange Commission under the Securities Act of 1933 and the
Securities Exchange Act of 1934, the following are true:

     2.1  ORGANIZATION AND STANDING. Matritech is a corporation duly organized
and validly existing under, and by virtue of, the laws of the State of Delaware
and is in good standing as a domestic corporation under the laws of said state
and is qualified as a foreign corporation in Massachusetts and in all other
jurisdictions in which such qualification is required; provided, however, that
Matritech need not be qualified in a jurisdiction in which its failure to
qualify would not have a material adverse effect on the business, properties,
prospects or financial condition of Matritech.

     2.2  CORPORATE POWER; AUTHORIZATION. Matritech has all requisite legal and
corporate power and has taken all requisite corporate action to execute and
deliver this Agreement and the Warrants, to sell and issue the Shares, the
Warrants and the Warrant Shares and to carry out and perform all of its
obligations under this Agreement and the Warrants. This Agreement and the
Warrants constitute the legal, valid and binding obligation of Matritech,
enforceable in accordance with their terms, except (i) as limited by applicable
bankruptcy, insolvency, reorganization or similar laws relating to or affecting
the enforcement of creditors' rights generally and (ii) as limited by equitable
principles generally. The execution and delivery of this Agreement and the
Warrants does not, and the performance of this Agreement and the Warrants and
the compliance with the provisions hereof and thereof and the issuance, sale and
delivery of the Shares, the Warrants and the Warrant Shares by Matritech will
not conflict with, or result in a breach or violation of the terms, conditions
or provisions of, or constitute a default under, or result in the creation or
imposition of any lien pursuant to the terms of the Amended and Restated
Certificate of Incorporation, as amended or the Amended and Restated Bylaws, as
amended, of Matritech or any statute, law, rule or regulation or any state or
federal order, judgement or decree or any indenture, mortgage, lease or other
agreement or instrument to which Matritech, or any of its assets or properties,
is subject.

     2.3  SHARES; WARRANT SHARES. The Shares and the Warrants (and the Warrant
Shares issuable upon exercise of the Warrants) when issued in compliance with
the provisions of this Agreement or the Warrants, as the case may be, will be
duly and validly authorized, issued, fully paid and nonassessable. Based on the
representations and warranties of the Purchaser contained herein, the Shares and
the Warrants (and the Warrant Shares) when issued in compliance with the
provisions of this Agreement or the Warrants, as the case may be, will be


<PAGE>   3


                                      -3-


issued in compliance with federal and state securities laws. The issuance and
delivery of the Shares and the Warrants (and the Warrant Shares upon exercise of
the Warrants) is not subject to preemptive or any other similar rights of the
stockholders of Matritech or any liens or encumbrances. Matritech has reserved
such number of shares of its Common Stock necessary for issuance of the Warrant
Shares.

     2.4  CAPITALIZATION. The capitalization of the Company is as set forth in
the Confidential Private Placement Memorandum of Matritech dated October 28,
1999 ("Memorandum") as of the date indicated therein. The Company has not issued
any capital stock since that date other than shares of Common Stock issued upon
exercise of outstanding options or warrants and shares of Common Stock issued in
accordance with the terms of the Memorandum.

     2.5  PRIVATE PLACEMENT MEMORANDUM; SEC DOCUMENTS; FINANCIAL STATEMENTS.
Each complete or partial statement, report, prospectus filed under the
Securities Act of 1933, as amended ("Securities Act"), or proxy statement
included in or referred to in the Memorandum is a true and complete copy of or
excerpt from such document as filed by Matritech with the Securities and
Exchange Commission ("SEC") ("SEC Documents"). Matritech has filed all the
documents that Matritech was required to file with the SEC under Sections 13 or
14(a) of the Securities Exchange Act of 1934, as amended ("Exchange Act"), since
the date on which its last report on Form 10-K was filed. As of their respective
filing dates, the SEC Documents complied in all material respects with the
requirements of the Exchange Act or the Securities Act, as applicable. Neither
the Memorandum nor any of the SEC Documents as of their respective dates
contained any untrue statement of a material fact or omitted to state a material
fact required to be stated therein or necessary to make the statements made
therein, in light of the circumstances under which they were made, not
misleading. The financial statements of Matritech included in the SEC Documents
or the Memorandum ("Financial Statements") comply as to form in all material
respects with applicable accounting requirements. Except as may be indicated in
the notes to the Financial Statements or, in the case of unaudited statements,
as permitted by Form 10-Q of the SEC, the Financial Statements have been
prepared in accordance with generally accepted accounting principles
consistently applied and fairly present the consolidated financial position of
Matritech and any subsidiaries at the dates thereof and the consolidated results
of their operations and consolidated cash flows for the periods then ended
(subject, in the case of unaudited statements, to normal, recurring
adjustments).

     2.6  GOVERNMENTAL CONSENTS. No consent, approval, order or authorization
of, or registration, qualification, designation, declaration or filing with, any
federal, state, or local governmental authority, including without limitation
the U.S. Food and Drug Administration, on the part of Matritech is required in
connection with the consummation of the transactions contemplated by this
Agreement except for (a) compliance with foreign securities laws in the
jurisdictions in which Units are offered and/or sold, (b) compliance with
federal securities laws and state "blue sky" laws in the jurisdictions in which
Units are offered and/or sold, which compliance will be effected in accordance
with such laws, (c) filing the Nasdaq National Market Notification Form for
listing of additional shares, which filing will be effected in accordance with
the rules thereunder or an appropriate waiver will be obtained, and (d) filing
with the SEC


<PAGE>   4


                                      -4-


and NASD either a Current Report on Form 8-K or a Quarterly or Annual Report on
Form 10-Q or 10-K disclosing the terms of the transaction contemplated by this
Agreement. The business of Matritech is not being conducted in violation of any
law, ordinance or regulation of any governmental entity, including but not
limited to the U.S. Food and Drug Administration, except for violations which
either singly or in the aggregate would not be reasonably likely to have a
material adverse effect on Matritech's business, financial condition or results
of operations.

     2.7  NO MATERIAL ADVERSE CHANGE. Except as otherwise disclosed herein or in
writing or otherwise set forth in the SEC Documents since June 30, 1999, there
has not been:

          (a) any changes in the assets, liabilities, financial condition,
operations or prospects of Matritech from that reflected in the Financial
Statements except changes in the ordinary course of business which have not
been, either in any individual case or in the aggregate, materially adverse;

          (b) any material change in the contingent obligations of Matritech,
whether by way of guarantee, endorsement, indemnity, warranty or otherwise;

          (c) any damage, destruction or loss, whether or not covered by
insurance, materially and adversely affecting the properties or business of
Matritech;

          (d) any declaration or payment of any dividend or other distribution
of the assets of Matritech;

          (e) any labor organization activity; or

          (f) any other event or condition of any character which has materially
and adversely affected Matritech's assets, liabilities, financial condition or
operations or prospects.

     2.8  INTELLECTUAL PROPERTY. Matritech has sufficient title and ownership of
all patents, patent applications, copyrights, trade secrets, trademarks,
proprietary information, proprietary rights, and processes necessary for its
business as now conducted and as now proposed to be conducted in the Memorandum
without any conflict with or infringement of the rights of others except as
disclosed in the documents filed with the SEC and appended to the Memorandum, to
the knowledge of Matritech. To the best of Matritech's knowledge, all issued
patents and registered trademarks and copyrights held by Matritech are valid and
subsisting. Matritech has taken all necessary and desirable action to maintain
and protect each item of intellectual property owned or used by Matritech. The
research, development, manufacture, sale, and use of products presently made,
used, or sold by, or contemplated for future manufacture, sale or use by
Matritech, as disclosed in the Memorandum, does not and would not constitute or
involve a significant risk of infringement of any patent or misappropriation of
any trade secret of any third party, except as disclosed in the Memorandum.
Except as disclosed in the documents filed with the SEC and appended to the
Memorandum, there are no outstanding options, licenses, or agreements of any
kind relating to any material use of the foregoing, nor is Matritech bound by or
a party to any options, licenses, encumbrances or liens, or any outstanding
orders, judgments, decrees, stipulations, or agreements of any kind with respect
to the patents,


<PAGE>   5


                                      -5-


trademarks, service marks, trade names, copyrights, trade secrets, licenses,
information, proprietary rights and processes of any other person or entity that
are material to Matritech's business as currently conducted or proposed to be
conducted in the Memorandum. Matritech has not received any communications
alleging that Matritech, by conducting its business as proposed, would violate
any of the patents, trademarks, service marks, trade names, copyrights, or trade
secrets or other proprietary rights of any other person or entity. Further,
there is no claim pending, or to the best of Matritech's knowledge, threatened
that challenges the validity, enforceability, ownership or right to use, sell,
license, or dispose of any item of intellectual property used or proposed to be
used by Matritech, and, to the best knowledge of Matritech, there is no basis
for any such claim (whether or not pending or threatened). Matritech is not
aware that any of its employees or consultants is obligated under any contract
(including licenses, covenants or commitments of any nature) or other agreement,
or subject to any judgement, decree or order of any court or administrative
agency, that is violated by or would materially interfere with the current or
prospective services provided to Matritech by the employee or consultant or the
use of his best efforts to promote the interests of Matritech or that would
materially conflict with Matritech's business as proposed to be conducted in the
Memorandum. Neither the execution nor delivery of this Agreement, nor the
carrying on of Matritech's business as proposed, will, to Matritech's knowledge,
conflict with or result in a material breach of the terms, conditions or
provisions of, or constitute a material default under, any contract, covenant or
instrument under which any of such employees is now obligated. To the knowledge
of Matritech, no third party is infringing upon or otherwise violating the
rights of Matritech in any of its intellectual property.

     2.9  LITIGATION. Matritech is not engaged in, or a party to, or threatened
with, any claim or legal action or other proceeding before any court, any
arbitrator of any kind or any administrative agency, or any governmental
investigation, which could have a material adverse effect on Matritech's
business, financial condition or results of operations, nor to Matritech's
knowledge does any basis for any claim or legal action or other proceeding or
governmental investigation exist. There are no orders, rulings, decrees,
judgments or stipulations to which Matritech is a party by or with any court,
arbitrator or administrative agency and to Matritech's knowledge, there are no
other such orders, rulings, decrees, judgments or stipulations affecting
Matritech's business, prospects, financial condition or results of operations.

     2.10 CONSISTENT TERMS. If Matritech shall enter into any other agreement,
side letter or other understanding with any other purchaser containing
additional or contrary undertakings or terms to those contained herein in
connection with the issuance and sale of Units at the Closing, Matritech shall
make such undertakings or terms available to Purchaser, PROVIDED, HOWEVER, that
Purchaser shall not be entitled to reimbursement for legal expenses incurred in
connection with the purchase of the Units.

     2.11 INSURANCE. Matritech and its subsidiaries carry insurance in such
amounts and covering such risks as are usually and customarily carried with
respect to similar businesses according to their respective locations. All
insurance premiums of Matritech have been fully paid as due, and the insurance
policies of Matritech and its subsidiaries are in full force and effect.

     2.12 TAXES. Matritech has accurately prepared and timely filed all federal,
state and other tax returns required by law to be filed by it, all such tax
returns are true and complete in all


<PAGE>   6


                                      -6-


respects, and all taxes (including all sales and withholding taxes) shown to be
due and all additional assessments have been paid. Matritech knows of no
additional assessments or adjustments pending or threatened against Matritech
for any period, nor of any basis for any such assessment or adjustment. The
federal income tax returns of Matritech have never been audited, or to the best
of Matritech's knowledge, threatened to be audited by the Internal Revenue
Service. There is no tax lien (other than for current taxes not yet due and
payable), whether imposed by any federal, state or other taxing authority,
outstanding against the assets, properties or business of Matritech.

     2.13 LOANS AND ADVANCES. Matritech has not made any loan or advance to any
person which is outstanding on the date of this Agreement, nor is Matritech
obligated or committed to make any such loan or advance, to any person except
for advances to employees of Matritech in respect of reimbursable business
expenses anticipated to be incurred by them in connection with their performance
of services for Matritech.

     2.14 NO BROKERS, FINDERS. Matritech represents that no person, firm or
corporation has or will have, as a result of any act or omission by Matritech,
any right, interest or valid claim against Purchaser for any commission, fee or
other compensation as a finder or broker, or in any similar capacity, in
connection with the transactions contemplated by this Agreement.

     2.15 TRANSACTIONS WITH AFFILIATES. To the best of Matritech's knowledge, no
director or officer of Matritech, or member of the "immediate family" (as such
term is defined in the instructions to Regulation S-K item 404(a) under the
Securities Act) of any such person, or any corporation, partnership, trust or
other entity in which any such person, or any member of the "immediate family"
(as such term is defined in the instructions to Regulation S-K item 404(a) under
the Securities Act) of any such person is an officer, director, trustee, partner
or holder of more than 5% of the outstanding capital stock thereof, is a party
to any transaction with Matritech, including any contract, agreement or other
arrangement providing for the employment of, furnishing of services by, rental
of real or personal property from or otherwise requiring payments to any such
person.

     2.16 EMPLOYEES. Each of the officers of Matritech and each key employee now
employed by Matritech, who has access to confidential information of Matritech
has executed a confidentiality, nondisclosure, and noncompetition agreement with
Matritech, and such agreements are in full force and effect. No officer or key
employee of Matritech has advised Matritech (orally or in writing) that he or
she intends to terminate employment with Matritech. To the best of Matritech's
knowledge, Matritech has complied in all material respects with all applicable
laws relating to the employment of labor, including provisions relating to
wages, hours, equal opportunity, collective bargaining and the payment of Social
Security and other taxes, and with the Employee Retirement Income Security Act
of 1974, as amended ("ERISA"). No officer or other key employee of Matritech is
a party to or bound by any agreement, contract or commitment, or subject to any
restrictions (including confidentiality or non-compete restrictions) in
connection with any previous or current employment of any such person, which
restricts, or in the future may restrict, the business of Matritech in any
burdensome or material respect.


<PAGE>   7


                                      -7-


     2.17 ENVIRONMENTAL MATTERS.

     (a)  Matritech has operated its properties, assets and operations in
material compliance with all applicable Environmental Laws (as defined below).
To the knowledge of Matritech, there have been no releases or threatened
releases of Hazardous Materials (as defined below) in, from, on or under any
property adjoining any of the property or assets of Matritech.

     (b)  To the knowledge of Matritech, none of the properties, assets or
operations of Matritech is the subject to any federal, state or local
investigation evaluating whether (i) any remedial action is needed to respond to
a release or threatened release of any Hazardous Materials (as defined below)
into the environment or (ii) any release or threatened release of any Hazardous
Materials (as defined below) into the environment or any such properties, assets
or operations of Matritech is in contravention of any Environmental Law (as
defined below).

     (c)  Matritech has not received any notice or claim, nor are there pending,
or, to the knowledge of Matritech, threatened or reasonably anticipated lawsuits
or proceedings against Matritech with respect to violations of an Environmental
Law (as defined below) or in connection with the presence of or exposure to any
Hazardous Materials (as defined below) into the environment or any release or
threatened release of any Hazardous Materials (as defined below) into the
environment. To the knowledge of Matritech, there are no events, conditions or
circumstances, including without limitation, the release of Hazardous Materials
(as defined below) in the environment which may result in Matritech or any of
its respective properties or assets being subject to any liability, either
present or contingent, pursuant to Environmental Laws (as defined below).

     (d)  For the purposes of this Section 2.17 (i) "Environmental Law" shall
mean any federal, state, territorial, provincial or local law, common law
doctrine, rule, code, ordinance, order, decree, judgment, injunction, license,
permit or regulation relating to pollution, protection of the environment or
human health and safety, including those pertaining to land use, air, soil,
surface water, ground water (including the protection, cleanup, removal, or
damage thereof), public or employee health or safety, emissions, discharges,
radio-frequency radiation, releases or threatened releases of any pollutant or
contaminant; and (ii)"Hazardous Materials" shall mean those substances, the
transport, emission, release, generation, handling, use, presence, storage or
disposal of which are regulated by or form the basis of liability under any
Environmental Laws.

                                    SECTION 3

                   REPRESENTATIONS AND WARRANTIES OF PURCHASER

     The Purchaser hereby represents and warrants to Matritech as of the Closing
Date as follows:

     3.1  INVESTMENT EXPERIENCE. Purchaser is an "accredited investor" as
defined in Rule 501(a) under the Securities Act. Purchaser is aware of
Matritech's business affairs and financial condition and has had access to and
has acquired sufficient information about Matritech


<PAGE>   8


                                      -8-


to reach an informed and knowledgeable decision to acquire the Units (and the
Warrant Shares issuable upon exercise of the Warrants). Purchaser has such
business and financial experience as is required to give it the capacity to
protect its own interests in connection with the purchase of the Units.

     3.2  INVESTMENT INTENT. Purchaser is purchasing the Units (and the Warrant
Shares upon exercise of the Warrants) for investment for its own account only
and not with a view to, or for resale in connection with, any "distribution"
thereof within the meaning of the Securities Act. Purchaser understands that the
Shares, the Warrants and the Warrant Shares have not been registered under the
Securities Act or registered or qualified under any state securities law in
reliance on specific exemptions therefrom, which exemptions may depend upon,
among other things, the bona fide nature of Purchaser's investment intent as
expressed herein.

     3.3  REGISTRATION OR EXEMPTION REQUIREMENTS. Purchaser further acknowledges
and understands that the Shares, the Warrants and the Warrant Shares must be
held indefinitely unless they are subsequently registered under the Securities
Act or an exemption from such registration is available. Purchaser understands
that the certificate(s) evidencing the Shares will be imprinted with a legend
that prohibits the transfer of the Shares unless (i) they are registered or such
registration is not required, and (ii) if the transfer is pursuant to an
exemption from registration other than Rule 144 under the Securities Act, and,
if Matritech shall so request in writing, an opinion of counsel satisfactory to
Matritech is obtained to the effect that the transaction is so exempt. In
addition, Purchaser will refrain from selling, transferring or otherwise
disposing of any Shares, the Warrants or the Warrant Shares, or any interest
therein, in such manner as to cause Matritech to be in violation of the
registration requirements of the Securities Act or applicable state securities
or blue sky laws.

     3.4  NO LEGAL, TAX OR INVESTMENT ADVICE. Purchaser understands that nothing
in this Agreement or any other materials presented to Purchaser in connection
with the purchase and sale of the Units (and the Warrant Shares issuable upon
exercise of the Warrants) constitutes legal, tax or investment advice. Purchaser
has consulted such legal, tax and investment advisors as it, in its sole
discretion, has deemed necessary or appropriate in connection with its purchase
of the Units (and the Warrant Shares issuable upon exercise of the Warrants).

     3.5  NO BROKERS, FINDERS. Purchaser represents that no person, firm or
corporation has or will have, as a result of any act or omission by Purchaser,
any right, interest or valid claim against Matritech for any commission, fee or
other compensation as a finder or broker, or in any similar capacity, in
connection with the transactions contemplated by this Agreement.

                                    SECTION 4

                     CONDITIONS TO OBLIGATIONS OF PURCHASER

Purchaser's obligation to purchase the Units at the Closing is subject to the
fulfillment on or prior to the Closing Date of the following conditions, unless
otherwise waived by Purchaser:


<PAGE>   9


                                      -9-


     4.1  REPRESENTATIONS AND WARRANTIES CORRECT. The representations and
warranties made by Matritech in Section 2 hereof shall be true and correct in
all material respects when made, and shall be true and correct in all material
respects on the Closing Date with the same force and effect as if they had been
made on and as of said date.

     4.2  COVENANTS. All covenants, agreements and conditions contained in this
Agreement to be performed by Matritech on or prior to the Closing Date shall
have been performed or complied with in all respects.

     4.3  OPINION OF COMPANY'S COUNSEL. Purchaser shall have received from
Testa, Hurwitz & Thibeault, LLP, counsel to Matritech, an opinion addressed to
it, dated the Closing Date, in substantially the form satisfactory to Purchaser
and its counsel and is customary for similar financial transactions.

     4.4  NO ORDER PENDING. There shall not then be in effect any order
enjoining or restraining the transactions contemplated by this Agreement.

     4.5  NO LAW PROHIBITING OR RESTRICTING SUCH SALE. There shall not be in
effect any law, rule or regulation prohibiting or restricting such sale, or
requiring any consent or approval of any person which shall not have been
obtained to issue the Units (except as otherwise provided in this Agreement).

     4.6  COMPLIANCE CERTIFICATE. Matritech shall have delivered to Purchaser a
certificate executed on behalf of Matritech by a duly authorized officer of
Matritech, dated the Closing Date, and certifying to the fulfillment of the
conditions specified in Sections 4.1 and 4.2. Notwithstanding the preceding
sentence, Matritech shall not be required to deliver such a certificate if the
Closing Date and the execution date of this Agreement are the same.

     4.7  NO MATERIAL ADVERSE CHANGE. There shall have been no material adverse
change between the date of this Agreement and the Closing Date in the financial
condition, prospects, business or affairs of Matritech.

     4.8  GOVERNMENTAL APPROVALS. All consents from governmental agencies
required to consummate the transaction contemplated hereby shall have been
obtained.

                                    SECTION 5

                     CONDITIONS TO OBLIGATIONS OF MATRITECH

     Matritech's obligation to sell and issue the Units at the Closing is
subject to the fulfillment on or prior to the Closing Date of the following
conditions by the Purchaser, unless otherwise waived by Matritech:


<PAGE>   10


                                      -10-


     5.1  REPRESENTATIONS AND WARRANTIES CORRECT. The representations and
warranties made by Purchaser in Section 3 hereof shall be true and correct in
all material respects.

     5.2  COVENANTS. All covenants, agreements and conditions contained in this
Agreement to be performed by Purchaser on or prior to the Closing Date shall
have been performed or complied with in all respects.

     5.3  NO ORDER PENDING. There shall not then be in effect any order
enjoining or restraining the transactions contemplated by this Agreement.

     5.4  NO LAW PROHIBITING OR RESTRICTING SUCH SALE. There shall not be in
effect any law, rule or regulation prohibiting or restricting such sale, or
requiring any consent or approval of any person which shall not have been
obtained to issue the Units (except as otherwise provided in this Agreement).

     5.5  GOVERNMENTAL APPROVALS. All consents from governmental agencies
required to consummate the transaction contemplated hereby shall have been
obtained.

                                    SECTION 6

                             COVENANTS OF MATRITECH

     Until the termination of this Agreement in accordance with Section 9.1
hereof or the particular covenant, as the case may be:

     6.1  WARRANTS. Matritech will comply with the provisions of the Warrants
contained in the Form of Warrant attached as Exhibit B hereto.

     6.2  REGISTRATION REQUIREMENTS.

          (a) As soon as reasonably practicable and in any event no later than
60 days after the Closing, Matritech shall prepare and file a registration
statement with the SEC under the Securities Act to register the resale of the
Shares and the Warrant Shares ("Registrable Securities") and thereafter shall
use its best efforts to secure the effectiveness of such registration statement.

          (b) Matritech shall pay all Registration Expenses (as defined below)
in connection with any registration, qualification or compliance hereunder, and
each holder of Registrable Securities ("Holder") shall pay all Selling Expenses
(as defined below) and other expenses that are not Registration Expenses
relating to the Registrable Securities resold by such Holder. "Registration
Expenses" shall mean all expenses, except for Selling Expenses, incurred by
Matritech in complying with the registration provisions herein described,
including, without limitation, all registration, qualification and filing fees,
printing expenses, escrow fees, fees and disbursements of counsel for Matritech,
blue sky fees and expenses and the expense of any special audits incident to or
required by any such registration. "Selling Expenses" shall mean all


<PAGE>   11


                                      -11-


selling commissions, underwriting fees and stock transfer taxes applicable to
the Registrable Securities and all fees and disbursements of counsel for any
Holder.

          (c) In the case of any registration effected by Matritech pursuant to
these registration provisions, Matritech will use its best efforts to: (i) keep
such registration effective until the later of such time as (A) all of the
Warrants have been exercised, redeemed or expired and (B) all of the Shares and
Warrant Shares have been sold pursuant thereto or, by reason of Rule 144(k)
under the Securities Act or any other rule of similar effect, such shares are no
longer required to be registered for the unrestricted sale thereof by the
Purchaser; (ii) prepare and file with the SEC such amendments and supplements to
such registration statement and the prospectus used in connection with such
registration statement as may be necessary to comply with the provisions of the
Securities Act with respect to the disposition of all securities covered by such
registration statement; (iii) furnish such number of prospectuses and other
documents incident thereto, including any amendment of or supplement to the
prospectus, as a Holder from time to time may reasonably request; (iv) use its
best efforts to register and qualify the securities covered by such registration
statement under such other securities or Blue Sky laws of such jurisdictions as
shall be reasonably requested by the Holders, provided that Matritech shall not
be required in connection therewith or as a condition thereto to qualify to do
business or to file a general consent to service of process in any such states
or jurisdictions; (v) cause all such Registrable Securities registered as
described herein to be listed on each securities exchange and quoted on each
quotation service on which similar securities issued by Matritech are then
listed or quoted; (vi) provide a transfer agent and registrar for all
Registrable Securities registered pursuant to such registration statement and a
CUSIP number for all Registrable Securities; and (vii) otherwise use its best
efforts to comply with all applicable rules and regulations of the SEC.

          (d) When a Holder is entitled to sell and gives notice of its intent
to sell pursuant to the registration statement, Matritech shall, within three
(3) trading days (subject to Section 7.1), furnish to such Holder a reasonable
number of copies of a supplement to or an amendment of such prospectus as may be
necessary so that, as thereafter delivered to the Holders of such shares, such
prospectus shall not include an untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the
statements therein not misleading or incomplete in the light of the
circumstances then existing.

          (e) The right to sell Registrable Securities pursuant to the
registration statement described herein will automatically be assigned to each
transferee of Registrable Securities. In the event that it is necessary, in
order to permit a Holder to sell Registrable Securities pursuant to Matritech's
registration statement, to amend the registration statement to name such Holder,
such Holder shall, upon written notice to Matritech, be entitled to have
Matritech make such amendment as soon as reasonably practicable. Notwithstanding
the above provisions relating to Registration Expenses, in the event that such
an amendment is requested, the Holder shall, at the request of Matritech, be
obligated to reimburse Matritech for reasonable Registration Expenses incurred
by it in connection with such amendment.

          (f) With a view to making available to the holders the benefits of
Rule 144 promulgated under the Securities Act and any other rule or regulation
of the SEC that may at any time permit a Holder to sell Registrable Securities
to the public without registration or pursuant


<PAGE>   12


                                      -12-


to a registration on Form S-3, Matritech hereby covenants and agrees to: (i)
make and keep public information available, as those terms are understood and
defined in Rule 144, at all times after the closing; (ii) file with the SEC in a
timely manner all reports and other documents required of Matritech under the
Securities Act and Exchange Act; and (iii) furnish to any Holder, as long as the
Holder owns any Registrable Securities forthwith upon request, (A) a written
statement by Matritech that it has complied with the reporting requirements of
Rule 144, the Securities Act and the Exchange Act, (B) a copy of the most recent
annual or quarterly report of Matritech, and (C) such other information as may
be reasonably requested in order to avail any Holder of any rule or regulation
of the SEC that permits the selling of any such Registrable Securities without
registration or pursuant to such Form S-3.

          (g) Indemnification.

               (i) To the extent permitted by law, Matritech will indemnify and
hold harmless each Holder against any losses, claims, damages, or liabilities
(including reasonable attorneys and experts fees and costs) to which such Holder
may become subject under the Act, the Securities Exchange Act of 1934, as
amended (the "Exchange Act") or other federal or state law, insofar as such
losses, claims, damages, or liabilities (or actions in respect thereof) arise
out of or are based upon any of the following statements, omissions or
violations (collectively a "Violation"): (A) any untrue statement of a material
fact contained in such registration statement, including any preliminary
prospectus or final prospectus contained therein or any amendments or
supplements thereto, (B) the omission to state therein a material fact required
to be stated therein, or necessary to make the statements therein not
misleading, or (C) any violation by Matritech of the Act, the Exchange Act, any
state securities law or any rule or regulation promulgated under the Act, the
Exchange Act or any state securities law; and Matritech will pay to each such
Holder, as incurred, any legal or other expenses reasonably incurred by them in
connection with investigating or defending any such loss, claim, damage,
liability, or action; provided, however, that the indemnity agreement contained
in this Section 6.2(g)(i) shall not apply to amounts paid in settlement of any
such loss, claim, damage, liability, or action if such settlement is effected
without the consent of Matritech (which consent shall not be unreasonably
withheld), nor shall Matritech be liable in any such case for any such loss,
claim, damage, liability, or action to the extent that it arises out of or is
based upon a Violation which occurs in reliance upon and in conformity with
written information furnished expressly for use in connection with such
registration by any such Holder.

               (ii) To the extent permitted by law, each selling Holder will
indemnify and hold harmless Matritech, each of its directors, each of its
officers who has signed the registration statement against any losses, claims,
damages, or liabilities (joint or several) to which any of the foregoing persons
may become subject, under the Act, the Exchange Act or other federal or state
law, insofar as such losses, claims, damages, or liabilities (or actions in
respect thereto) arise out of or are based upon any Violation, in each case to
the extent (and only to the extent) that such Violation occurs in reliance upon
and in conformity with written information furnished by such Holder expressly
for use in connection with such registration; and each such Holder will pay, as
incurred, any legal or other expenses reasonably incurred by any person intended
to be indemnified pursuant to this subsection 6.2(g)(ii), in connection with
investigating or defending any such loss, claim, damage, liability, or action;
provided, however, that the indemnity


<PAGE>   13


                                      -13-


agreement contained in this subsection 6.2(g)(ii) shall not apply to amounts
paid in settlement of any such loss, claim, damage, liability or action if such
settlement is effected without the consent of the Holder, which consent shall
not be unreasonably withheld; provided, that, in no event shall any indemnity
under this subsection 6.2(g)(ii) exceed the net proceeds from the offering
received by such Holder, except in the case of willful fraud by such Holder.

               (iii) Promptly after receipt by an indemnified party under this
Section 6.2(g) of notice of the commencement of any action (including any
governmental action), such indemnified party will, if a claim in respect thereof
is to be made against any indemnifying party under this Section 6.2(g), deliver
to the indemnifying party a written notice of the commencement thereof and the
indemnifying party shall have the right to participate in, and, to the extent
the indemnifying party so desires, jointly with any other indemnifying party
similarly noticed, to assume the defense thereof with counsel mutually
satisfactory to the parties; provided, however, that an indemnified party
(together with all other indemnified parties which may be represented without
conflict by one counsel) shall have the right to retain one separate counsel,
with the reasonable fees and expenses to be paid by the indemnifying party, if
representation of such indemnified party by the counsel retained by the
indemnifying party would be inappropriate due to actual or potential differing
interests between such indemnified party and any other party represented by such
counsel in such proceeding. The failure to deliver written notice to the
indemnifying party within a reasonable time of the commencement of any such
action, if prejudicial to its ability to defend such action, shall relieve such
indemnifying party of any liability to the indemnified party under this Section
6.2(g), but the omission so to deliver written notice to the indemnifying party
will not relieve it of any liability that it may have to any indemnified party
otherwise than under this Section 6.2(g).

               (iv) If the indemnification provided for in this Section 6.2(g)
is held by a court of competent jurisdiction to be unavailable to an indemnified
party with respect to any loss, liability, claim, damage, or expense referred to
therein, then the indemnifying party, in lieu of indemnifying such indemnified
party hereunder, shall contribute to the amount paid or payable by such
indemnified party as a result of such loss, liability, claim, damage, or expense
in such proportion as is appropriate to reflect the relative fault of the
indemnifying party on the one hand and of the indemnified party on the other in
connection with the statements or omissions that resulted in such loss,
liability, claim, damage, or expense as well as any other relevant equitable
considerations; provided, that, in no event shall any contribution by a Holder
under this subsection 6.2(g)(iv) exceed the net proceeds from the offering
received by such Holder, except in the case of willful fraud by such Holder. The
relative fault of the indemnifying party and of the indemnified party shall be
determined by reference to, among other things, whether the untrue or alleged
untrue statement of a material fact or the omission to state a material fact
relates to information supplied by the indemnifying party or by the indemnified
party and the parties' relative intent, knowledge, access to information, and
opportunity to correct or prevent such statement or omission.

               (v) The obligations of Matritech and Holders under this Section
6.2(g) shall survive the completion of any offering of Registrable Securities in
a registration statement under this Section 6.2(g), and otherwise.


<PAGE>   14


                                      -14-


                                    SECTION 7

                             COVENANTS OF PURCHASER

     7.1  NOTICE TO COMPANY OF PROPOSED SALE AND RIGHT OF COMPANY TO SUSPEND USE
OF REGISTRATION STATEMENT. If the Purchaser shall propose to sell any
Registrable Securities pursuant to the registration statement, it shall notify
Matritech of its intent to do so at least three (3) full trading days prior to
such sale, and the provision of such notice to Matritech shall conclusively be
deemed to establish an agreement by the Purchaser to comply with the
registration provisions herein described. Unless otherwise specified in such
notice, such notice shall be deemed to constitute a representation that any
information previously supplied by the Purchaser is accurate as of the date of
such notice. At any time within such three (3) trading-day period, Matritech may
refuse to permit the Purchaser to resell any Registrable Securities pursuant to
the registration statement; provided, however, that in order to exercise this
right, Matritech must deliver a certificate in writing to the Purchaser to the
effect that a delay in such sale is necessary because a sale pursuant to such
registration statement in its then-current form could constitute a violation of
the federal securities laws. In no event shall such delay exceed ten (10)
trading days; provided, however, that if, prior to the expiration of such ten
(10) trading day period, Matritech delivers a certificate in writing to the
Purchaser to the effect that a further delay in such sale beyond such ten (10)
trading day period is necessary because the disclosures required to be made for
a sale pursuant to such registration statement to be in compliance with federal
securities laws would be seriously detrimental to Matritech and its
stockholders, Matritech may refuse to permit the Purchaser to resell any
Registrable Securities pursuant to the registration statement for an additional
period not to exceed ten (10) trading days. Matritech may not utilize this right
more than once in any three (3) month period.

     7.2  RESTRICTIONS ON SHORT-SALES. The Purchaser shall not engage in any
short-sales of Matritech's Common Stock prior to the effectiveness of the
Registration Statement, except to the extent that any such short-sale is fully
covered by freely tradable shares of Common Stock of Matritech.

                                    SECTION 8

                    RESTRICTIONS ON TRANSFERABILITY OF SHARES

                         COMPLIANCE WITH SECURITIES ACT

     8.1  RESTRICTIONS ON TRANSFERABILITY. The Shares, Warrants and Warrant
Shares shall not be transferable in the absence of a registration under the
Securities Act or an exemption therefrom or in the absence of compliance with
any term of this Agreement. Matritech shall be entitled to give stop transfer
instructions to the transfer agent with respect to the Shares in order to
enforce the foregoing restrictions.

     8.2  RESTRICTIVE LEGEND. Each certificate representing Shares, Warrants and
Warrant Shares shall bear substantially the following legends (in addition to
any legends required under applicable securities laws):


<PAGE>   15


                                      -15-


     THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE BEEN ACQUIRED FOR
     INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933.

     THE SHARES MAY NOT BE SOLD OR TRANSFERRED IN THE ABSENCE OF SUCH
     REGISTRATION OR AN EXEMPTION THEREFROM.

     UNTIL FEBRUARY 20, 2000 THE SHARES REPRESENTED BY THIS CERTIFICATE MAY NOT
     BE SOLD OR TRANSFERRED UNLESS PRIOR NOTICE SHALL HAVE BEEN GIVEN TO
     MATRITECH.

     The legend contained in this Section 8.2 will be removed from a certificate
if (i) Matritech receives an opinion of counsel reasonably satisfactory to
Matritech that the Shares or Warrant Shares represented by such certificates are
available for resale pursuant to Rule 144 under the Securities Act, or (ii) in
Matritech's opinion the Shares or Warrant Shares represented by such
certificates are available for resale pursuant to Rule 144(k) under the
Securities Act, or (iii) such Shares or Warrant Shares are sold pursuant to an
effective registration statement with the SEC.

     8.3  LOCK-UP. Purchaser agrees that it will not sell or otherwise dispose
of any Shares or Warrant Shares for a period of ninety (90) days following the
Closing Date.

                                    SECTION 9

                                  MISCELLANEOUS

     9.1  TERMINATION OF AGREEMENT.

          (a) This Agreement may be terminated at any time prior to the
Effective Time by Matritech or Purchaser if there has been a material breach of
any material representation, warranty, covenant or agreement on the part of the
other party set forth in this agreement, which breach shall not have been cured,
in the case of a representation or warranty, prior to the Closing or, in the
case of a covenant or agreement, within thirty (30) calendar days following
receipt by the breaching party of written notice of such breach from the other
party.

          (b) From and after the termination of this Agreement, the covenants,
obligations and agreements of the parties set forth herein shall be of no
further force or effect and the parties shall be under no further obligation
with respect thereto.

     9.2  COMMERCIALLY REASONABLE EFFORTS. Matritech and Purchaser shall use its
commercially reasonable efforts to take all actions required under any law, rule
or regulation adopted subsequent to the date hereof in order that Matritech may
sell the Units to Purchaser and Purchaser may purchase the Units, and to ensure
that the conditions to a Closing set forth herein are satisfied on or before the
scheduled date of such Closing.


<PAGE>   16


                                      -16-

     9.3  GOVERNING LAW. This Agreement shall be governed in all respects by the
laws of the State of Delaware as applied to contracts entered into solely
between residents of, and to be performed entirely within, such state.

     9.4  SURVIVAL. The representations and warranties, in Sections 2 and 3 of
this Agreement shall survive any investigation made by Purchaser or Matritech
and the Closing; provided that such representations and warranties shall not be
construed so as to constitute representations and warranties concerning
circumstances existing after the date of this Agreement.

     9.5  SUCCESSORS AND ASSIGNS. This Agreement shall be binding upon and shall
inure to the benefit of the parties hereto and their respective successors and
assigns. This Agreement may not be assigned by a party without the prior written
consent of the other party.

     9.6  ENTIRE AGREEMENT; AMENDMENT. This Agreement, the Warrants and the
other documents delivered pursuant hereto constitute the full and entire
understanding and agreement between the parties with regard to the subject
matter hereof and thereof and supersedes all prior agreements and understandings
among the parties relating to the subject matter hereof. The terms of this
Agreement may be waived or amended with the written consent of Matritech and
Purchaser.

     9.7  NOTICES AND DATES. Any notice or other communication given under this
Agreement shall be sufficient if in writing and sent by registered or certified
mail, domestic or international courier, or facsimile, return receipt requested,
postage or courier charges prepaid, to a party at its address set forth below
(or at such other address as shall be designated for such purpose by such party
in a written notice to the other party hereto):

          (a) if to Matritech, to:

          Matritech, Inc.
          330 Nevada Street
          Newton, MA  02460
          Attention: Chief Executive Officer

          with a copy to:

          Rufus C. King, Esq.
          Testa, Hurwitz & Thibeault, LLP
          125 High Street
          Boston, MA  02110

          (b) if to Purchaser, to the address set forth on the attached
          Schedule of Purchasers
          All such notices and communications shall be effective one (1) trading
day after being sent by courier or by facsimile with confirmation of receipt or
five (5) trading days after being sent by the other approved methods.


<PAGE>   17


                                      -17-


     9.8  SEVERABILITY. If any term, provision, covenant or restriction of this
Agreement is held by a court of competent jurisdiction to be invalid, void or
unenforceable, the remainder of the terms, provisions, covenants and restriction
of this Agreement shall remain in full force and effect and shall in no way be
affected, impaired or invalidated.

     9.9  COSTS AND EXPENSES. Each party hereto shall pay its own costs and
expenses incurred in connection herewith, including the fees of its counsel,
auditors and other representatives, whether or not the transactions contemplated
herein are consummated.

     9.10 ATTORNEYS' FEES. If any action at law or in equity is necessary to
enforce or interpret the terms of this Agreement, the prevailing party shall be
entitled to reasonable attorneys' fees, costs and necessary disbursements in
addition to any other relief to which such party may be entitled.

     9.11 COUNTERPARTS. This Agreement may be executed in counterparts, and each
such counterpart shall be deemed an original for all purposes, but such
counterparts shall together constitute one and the same instrument.

     9.12 BROKERAGE. Each party hereto will indemnify and hold harmless the
other against and in respect of any claim for brokerage or other commissions
relative to this Agreement or to the transactions contemplated hereby, based in
any way on agreements, arrangement or understandings made or claimed to have
been made by such party with any third party.

     9.13 PARTIES IN INTEREST. All representations, convenants and agreements,
contained in this Agreement by or on behalf of any of the parties hereto shall
bind and inure to the benefit of the respective successors and assigns of the
parties hereto whether so expressed or not.

     9.14 EQUITABLE RELIEF. Each of the parties acknowledges that any breach by
such party of its obligations under this Agreement would cause substantial and
irreparable damage to one or more of the other parties and that money damages
would be an inadequate remedy therefor. Accordingly, each party agrees that the
other parties or any of them shall be entitled to an injunction, specific
performance and/or other equitable relief to prevent the breach of such
obligations.


                  [Remainder of Page Intentionally Left Blank]


<PAGE>   18


                                      -18-


     IN WITNESS WHEREOF, the parties hereto have caused this Common Stock and
Warrant Purchase Agreement to be executed by their duly authorized
representatives as of the following date.


Dated:  November ___, 1999

                                           MATRITECH, INC.


                                           By:__________________________________
                                              Title:

           [Purchaser Signature Page Continues on the Following Page]


<PAGE>   19


                   PURCHASER SIGNATURE PAGE AND QUESTIONNAIRE

     The undersigned Purchaser hereby executes the Common Stock and Warrant
Purchase Agreement with Matritech, Inc. (the "Company") and hereby authorizes
this signature page to be attached to a counterpart of such document executed by
a duly authorized officer of the Company.

No. of Units to be                                ______________________________
Purchased:_______________                         Name of Purchaser   [PLEASE
                                                  PRINT OR TYPE]

Aggregate Purchase                                By:___________________________
Price $__________________                                     [SIGN HERE]

                                                  Title:________________________

Purchaser is an "accredited investor" as defined in Regulation D under the
Securities Act of 1933.

Name in which Shares and
Warrants are to be registered:                    ______________________________

Address of registered holder:                     ______________________________

                                                  ______________________________

Social Security or Tax ID Number:                 ______________________________

Contact name and telephone number
regarding settlement and                          ______________________________
registration:                                           Name

                                                  ______________________________
                                                       Telephone Number

Number of shares of common stock of the Company beneficially owned (meaning
shares owned or controlled or which the Purchaser has the right to acquire or
vote) by the Purchaser, other than the Shares being purchased pursuant
hereto:____________________

Have you or your organization had any position, office or other material
relationship with the Company within the past three years? _____ Yes _____ No

Do you or your organization have any direct or indirect affiliation or
association with any NASD member?                          _____ Yes _____ No

If "Yes" to either of the last two questions, please indicate the nature of any
such relationships below:


<PAGE>   20


                                    EXHIBIT A

                             SCHEDULE OF PURCHASERS

<TABLE>
<CAPTION>
PURCHASER                                           NUMBER OF UNITS
- ---------                                           ---------------
<S>                                                 <C>
</TABLE>

<PAGE>   1
                                                                     EXHIBIT 4.2

     THESE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND HAVE NOT BEEN
     REGISTERED UNDER THE U.S. SECURITIES ACT OF 1933. THEY MAY NOT BE SOLD,
     OFFERED FOR SALE OR TRANSFERRED EXCEPT IN ACCORDANCE WITH THE PROVISIONS OF
     THIS WARRANT AND PURSUANT TO A REGISTRATION STATEMENT OR AN OPINION OF
     COUNSEL SATISFACTORY TO THE COMPANY AS TO THE AVAILABILITY OF AN EXEMPTION
     FROM REGISTRATION.

Warrant No.  _______                                  Number of Shares: ________

                           WARRANT TO PURCHASE SHARES
                               OF COMMON STOCK OF

                                 MATRITECH, INC.

     1. COMMON STOCK AND WARRANT PURCHASE AGREEMENT. This Warrant is issued to
____________________________ ("Purchaser") pursuant to the Common Stock and
Warrant Purchase Agreement dated as of November ___, 1999 between Matritech,
Inc., a Delaware corporation ("Matritech" or the "Company"), and Purchaser
("Purchase Agreement") in which Matritech issued ___________ Units to Purchaser.
Each "Unit" is composed of two (2) shares of Matritech Common Stock ("Shares")
and a warrant to purchase one share of Matritech Common Stock. This Warrant is
part of the Unit.

     2. NUMBER AND PRICE OF SHARES SUBJECT TO WARRANT.

          (a) GENERAL TERMS. Subject to the terms and conditions herein set
forth Purchaser is entitled to purchase from Matritech, at any time in whole or
from time to time in part commencing on the date hereof and until November 22,
2001, ______________________________ (___________) shares (which number of
shares is subject to adjustment as described below) of fully paid and
nonassessable Common Stock, $.01 par value, of Matritech ("WARRANT SHARES"),
upon surrender of this Warrant at the principal office of Matritech and upon
payment of the purchase price by wire transfer to Matritech or cashiers check
drawn on a United States bank made to the order of Matritech. Subject to
adjustment as hereinafter provided, the purchase price of one Warrant Share (or
such securities as may be substituted for one Warrant Share pursuant to the
provisions hereinafter set forth) shall be $2.20. The purchase price of one
Warrant Share (or such securities as may be substituted for one Warrant Share
pursuant to the provisions hereinafter set forth) payable from time to time upon
the exercise of this Warrant (whether such price be the price specified above or
an adjusted price determined as hereinafter provided) is referred to herein as
the "WARRANT PRICE."

          (b) EARLY TERMINATION OF WARRANT. Notwithstanding the foregoing, in
the event that the average of the daily high and low bid price per share of
Matritech's Common Stock as reported on the Nasdaq Stock Market (or such other
equivalent market or exchange) exceeds $4.00 for a period of thirty (30)
consecutive trading days (a "CALLABLE EVENT"), then Matritech


<PAGE>   2


                                      -2-


may, on or before the tenth (10th) trading day after such Callable Event has
occurred, send a written notice (a "CALL NOTICE") to Purchaser that a Callable
Event has occurred and that the Warrant shall terminate on the thirtieth (30th)
day after the date the Call Notice became effective pursuant to Section 12
below. Purchaser shall have thirty (30) days after the date such Call Notice
became effective to exercise this Warrant in accordance with the terms and
conditions of this Warrant. In the event Purchaser does not exercise this
Warrant within such thirty (30) day period, this Warrant shall automatically
terminate. Notwithstanding the foregoing thirty (30) day period with which
Purchaser may exercise the Warrant after a Call Notice has been delivered, if
during such time period, (i) the registration statement described in the
Purchase Agreement covering such Warrant Shares (the "REGISTRATION STATEMENT")
shall not be effective, or (ii) Matritech shall have delayed Purchaser's ability
to sell securities covered by the Registration Statement, then, in either case,
the time period that Purchaser has to exercise the Warrant after a Call Notice
becomes effective shall be extended until the Purchaser shall have been
permitted to sell the Warrant Shares pursuant to the Registration Statement for
a period of thirty (30) consecutive days after the date the Call Notice shall
have been delivered; provided, however, there shall be no extension of time if
the time period required to keep the Registration Statement effective pursuant
to the Purchase Agreement shall have lapsed. If after the issue date of this
Warrant the Nasdaq Stock Market shall permit "after-hours" trading or continuous
trading, then for the purposes of determining the average of "daily high and low
bid price" as of any date, such prices on any trading day shall be deemed to be
the high and low bid prices during the "regular trading hours" designated as
such by Nasdaq, or if no such period shall be so designated, then the high and
low bid prices for such trading day as reported on the next Business Day by The
Wall Street Journal.

     3. ADJUSTMENT OF WARRANT PRICE AND NUMBER OF SHARES. The number and kind of
securities issuable upon the exercise of this Warrant shall be subject to
adjustment from time to time upon the happening of certain events as follows:

          (a) ADJUSTMENT FOR DIVIDENDS IN STOCK OR OTHER SECURITIES OR PROPERTY.
In case at any time or from time to time on or after the date hereof the holders
of the Common Stock of Matritech (or any shares of stock or other securities at
the time receivable upon the exercise of this Warrant) shall have received, or,
on or after the record date fixed for the determination of eligible
stockholders, shall have become entitled to receive, without payment therefor,
other or additional stock or other securities or property (other than cash in
connection with regular or ordinary dividends) of Matritech by way of dividend,
then and in each case, the holder of this Warrant shall, upon the exercise
hereof, be entitled to receive, in addition to the number of shares of Common
Stock receivable thereupon, and without payment of any additional consideration
therefor, the amount of such other or additional stock or other securities or
property (other than cash in connection with regular or ordinary dividends) of
Matritech which such holder would hold on the date of such exercise had it been
the holder of record of such Common Stock on the date hereof and had thereafter,
during the period from the date hereof to and including the date of such
exercise, retained such shares and/or all other additional stock available by it
as aforesaid during such period, giving effect to all adjustments called for
during such period by paragraphs (b) and (c) of this Section 3.


<PAGE>   3


                                      -3-


          (b) ADJUSTMENT FOR RECLASSIFICATION, REORGANIZATION OR MERGER. In case
of any reclassification or change of the outstanding securities of Matritech or
of any reorganization of Matritech (or any other corporation the stock or
securities of which are at the time receivable upon the exercise of this
Warrant) or any similar corporate reorganization on or after the date hereof,
then and in each such case the holder of this Warrant, upon the exercise hereof
at any time after the consummation of such reclassification, change,
reorganization, merger or conveyance, shall be entitled to receive, in lieu of
the stock or other securities and property receivable upon the exercise hereof
prior to such consummation, the stock or other securities or property to which
such holder would have been entitled upon such consummation if such holder had
exercised this Warrant immediately prior thereto, all subject to further
adjustment as provided in paragraphs (a) and (c); and in each such case, the
terms of this Section 3 shall be applicable to the shares of stock or other
securities properly receivable upon the exercise of this Warrant after such
consummation.

          (c) STOCK SPLITS AND REVERSE STOCK SPLITS. If at any time on or after
the date hereof Matritech shall subdivide its outstanding shares of Common Stock
into a greater number of shares, the Warrant Price in effect immediately prior
to such subdivision shall thereby be proportionately reduced and the number of
shares receivable upon exercise of the Warrant shall thereby be proportionately
increased; and, conversely, if at any time on or after the date hereof the
outstanding number of shares of Common Stock shall be combined into a smaller
number of shares, the Warrant Price in effect immediately prior to such
combination shall thereby be proportionately increased and the number of shares
receivable upon exercise of Warrant shall thereby be proportionately decreased.

     4. NO FRACTIONAL SHARES. No fractional shares of Warrant Shares will be
issued in connection with any exercise of this Warrant. In lieu of any
fractional shares which would otherwise be issuable, Matritech shall pay cash
equal to the product of such fraction multiplied by the closing price of one
Warrant Share as reported on the Nasdaq System on the date of exercise.

     5. NO STOCKHOLDER RIGHTS. This Warrant shall not entitle its holder to any
of the rights of a stockholder of Matritech.

     6. RESERVATION OF STOCK. Matritech covenants that during the period this
Warrant is exercisable, Matritech will reserve from its authorized and unissued
Common Stock a sufficient number of shares to provide for the issuance of
Warrant Shares upon the exercise of this Warrant. Matritech agrees that its
issuance of this Warrant shall constitute full authority to its officers who are
charged with the duty of executing stock certificates to execute and issue the
necessary certificates for the Warrant Shares upon the exercise of this Warrant.

     7. EXERCISE OF WARRANT. This Warrant may be exercised by the holder hereof,
in whole or in part, by the surrender of this Warrant and the Notice of Exercise
attached hereto as EXHIBIT A duly completed and executed on behalf of the holder
hereof, at the principal office of Matritech together with payment in full of
the Warrant Price then in effect with respect to the number of Warrant Shares as
to which the Warrant is being exercised. The Warrant Price shall be by wire
transfer to Matritech or cashiers check drawn on a United States bank made to
the


<PAGE>   4


                                      -4-


order of Matritech. This Warrant shall be deemed to have been exercised
immediately prior to the close of business on the date of its surrender for
exercise and payment of the applicable Warrant Price as provided above, and the
person entitled to receive the Warrant Shares issuable upon such exercise shall
be treated for all purposes as the holder of such shares of record as of the
close of business on such date. As promptly as practicable on or after such date
and in any event within ten (10) days thereafter, Matritech at its expense shall
cause to be issued and delivered to the person or persons entitled to receive
the same a certificate or certificates for the number of full Warrant Shares
issuable upon such exercise, together with cash in lieu of any fraction of a
share as provided above. The Warrant Shares issuable upon exercise hereof shall,
upon their issuance, be fully paid and nonassessable. In the event that this
Warrant is exercised in part, Matritech at its expense will execute and deliver
a new Warrant of like tenor exercisable for the number of shares for which this
Warrant may then be exercised.

     8. CERTIFICATE OF ADJUSTMENT. Whenever the Warrant Price or number or type
of securities issuable upon exercise of this Warrant is adjusted, as herein
provided, Matritech shall promptly deliver to the record holder of this Warrant
a certificate of an officer of Matritech setting forth the nature of such
adjustment and a brief statement of the facts requiring such adjustment.

     9. TRANSFERABILITY. This Warrant is not transferable.

     10. REPLACEMENT OF WARRANTS. On receipt of evidence reasonably satisfactory
to Matritech of the loss, theft, destruction or mutilation of any Warrant and,
in the case of any such loss, theft or destruction of any Warrant, on delivery
of an indemnity agreement or security reasonably satisfactory in form and amount
to Matritech or, in the case of any such mutilation, on surrender and
cancellation of such Warrant, Matritech at its expense will execute and deliver,
in lieu thereof, a new Warrant of like tenor.

     11. REPRESENTATIONS OF MATRITECH. Matritech represents and warrants to
Purchaser that the representations and warranties as set forth in Section 2 of
the Purchase Agreement are true and correct in all material respects as of the
date hereof.

     12. MISCELLANEOUS. This Warrant shall be governed by the laws of the State
of Delaware. The headings in this Warrant are for purposes of convenience and
reference only, and shall not be deemed to constitute a part hereof. Neither
this Warrant nor any term hereof may be changed, waived, discharged or
terminated orally but only by an instrument in writing signed by Matritech and
the registered holder of this Warrant. All notices and other communications from
Matritech to the holder of this Warrant shall be sufficient if in writing and
sent by registered or certified mail, domestic or international courier, or
facsimile, return receipt requested, postage or courier charges prepaid, to the
address furnished to Matritech in writing by Purchaser. All such notices and
communications shall be effective one (1) trading day after being sent by
courier or by facsimile with confirmation of receipt or five (5) trading days
after being sent by the other approved methods. The invalidity or
unenforceability of any provision hereof shall in no way affect the validity or
enforceability of any other provisions.


<PAGE>   5


                                      -5-


     13. ATTORNEY'S FEES. If any action at law or in equity is necessary to
enforce or interpret the terms of this Warrant, the prevailing party shall be
entitled to reasonable attorneys' fees, costs and necessary disbursements in
addition to any other relief to which such party may be entitled.

     14. TERMINATION. This Warrant (and the right to purchase securities upon
exercise hereof) shall terminate on November 22, 2001 or such earlier time as
provided in Section 2 above.

     ISSUED as of the date first written above.

                                                 MATRITECH, INC.


                                                 By:____________________________
                                                    Stephen D. Chubb
                                                    Chairman and Chief Executive
                                                     Officer


<PAGE>   6

                                    EXHIBIT A

                          NOTICE OF INTENT TO EXERCISE
                  (To be signed only upon exercise of Warrant)

To:  MATRITECH, INC.

The undersigned, the Holder of the within Warrant, hereby irrevocably elects to
exercise the purchase right represented by such Warrant for, and to purchase
thereunder, _____________ ____________________________ (_____________) shares of
Common Stock of Matritech, Inc. and herewith makes payment of
____________________ Dollars ($__________) thereof and requests that the
certificates for such shares be issued in the name of, and delivered to
________________________________, whose address is ____________________________.

     DATED: ______________

                                         _______________________________________
                                         (Signature must conform in all respects
                                         to name of Holder as specified on the
                                         face of the Warrant)


                                         _______________________________________

                                         _______________________________________
                                         (Address)


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