MATRITECH INC/DE/
SC 13G/A, 2000-02-14
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               (AMENDMENT NO. 1)*



                                 Matritech, Inc.
               --------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.01 par value
               --------------------------------------------------
                         (Title of Class of Securities)

                                    576818108
               --------------------------------------------------
                                 (CUSIP Number)



                                December 31, 1999
               --------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

     [ ] Rule 13d-1(b)
     [X] Rule 13d-1(c)
     [ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act,
but shall be subject to all other provisions of the Act (however, see the
Notes).


                               Page 1 of 8 pages


<PAGE>   2



- -------------------                                       ----------------------
CUSIP No. 576818108                   13G                 Page  2  of  8  Pages
- -------------------                                       ----------------------


- --------------------------------------------------------------------------------
 1    NAMES OF REPORTING PERSONS/I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
      (ENTITIES ONLY)

      Zero Stage Capital Co., Inc.

- --------------------------------------------------------------------------------

 2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
                                                         (a) [ ]
      N/A                                                (b) [ ]
- --------------------------------------------------------------------------------
 3    SEC USE ONLY


- --------------------------------------------------------------------------------
 4    CITIZENSHIP OR PLACE OF ORGANIZATION

      Massachusetts
- --------------------------------------------------------------------------------
                        5    SOLE VOTING POWER

                             -00- shares
    NUMBER OF          ---------------------------------------------------------
     SHARES             6    SHARED VOTING POWER
  BENEFICIALLY
    OWNED BY                 -00- shares -- But please also refer to Item 4 (a).
      EACH             --------------------------------------------------------
    REPORTING           7    SOLE DISPOSITIVE POWER
   PERSON WITH
                             -00- shares
                       ---------------------------------------------------------
                        8    SHARED DISPOSITIVE POWER

                             -00- shares - - But please refer to Item 4(a).
- --------------------------------------------------------------------------------
 9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      0 shares -- But please refer to Item 4 (a).
- --------------------------------------------------------------------------------
10    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
      (SEE INSTRUCTIONS)

      N/A                                                           [ ]
- --------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      0.0%
- --------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

      CO
- --------------------------------------------------------------------------------

                               Page 2 of 8 pages

<PAGE>   3


- -------------------                                       ----------------------
CUSIP No. 576818108                   13G                 Page  3  of  8  Pages
- -------------------                                       ----------------------


- --------------------------------------------------------------------------------
 1    NAMES OF REPORTING PERSONS/I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
      (ENTITIES ONLY)

      Zero Stage Capital Associates VI, LLC

- --------------------------------------------------------------------------------
 2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

                                                        (a) [ ]
      N/A                                               (b) [ ]
- --------------------------------------------------------------------------------
 3    SEC USE ONLY


- --------------------------------------------------------------------------------
 4    CITIZENSHIP OR PLACE OF ORGANIZATION

      Massachusetts
- --------------------------------------------------------------------------------
                         5    SOLE VOTING POWER

                              1,325,581 shares
    NUMBER OF           --------------------------------------------------------
     SHARES              6    SHARED VOTING POWER
  BENEFICIALLY
    OWNED BY                  -0- shares
      EACH              --------------------------------------------------------
    REPORTING            7    SOLE DISPOSITIVE POWER
   PERSON WITH
                              1,325,581 shares
                        --------------------------------------------------------
                         8    SHARED DISPOSITIVE POWER

                              -0- shares
- --------------------------------------------------------------------------------
 9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,325,581 shares
- --------------------------------------------------------------------------------
10    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
      (SEE INSTRUCTIONS)

      N/A                                                      [ ]
- --------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      6.10%
- --------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

      00
- --------------------------------------------------------------------------------


                                Page 3 of 8 pages
<PAGE>   4


- -------------------                                       ----------------------
CUSIP No. 576818108                   13G                 Page  4  of  8  Pages
- -------------------                                       ----------------------

- --------------------------------------------------------------------------------
 1    NAMES OF REPORTING PERSONS/I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
      (ENTITIES ONLY)

      Zero Stage Capital VI Limited Partnership
- --------------------------------------------------------------------------------
 2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
                                                          (a) [ ]
      N/A                                                 (b) [ ]
- --------------------------------------------------------------------------------
 3    SEC USE ONLY


- --------------------------------------------------------------------------------
 4    CITIZENSHIP OR PLACE OF ORGANIZATION

      Massachusetts
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER

                                  -0- shares
                            ----------------------------------------------------
    NUMBER OF                6    SHARED VOTING POWER
     SHARES
  BENEFICIALLY                    -0- shares -- But please refer to Item 4 (a).
    OWNED BY                ----------------------------------------------------
      EACH                   7    SOLE DISPOSITIVE POWER
    REPORTING
   PERSON WITH                    -0- shares
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER

                                  -0- shares -- But please refer to Item 4 (a).
- --------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      0 shares -- But please refer to Item 4 (a).
- --------------------------------------------------------------------------------
10    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
      (SEE INSTRUCTIONS)

      N/A                                                       [ ]
- --------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      0.0%
- --------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

      PN
- --------------------------------------------------------------------------------


                               Page 4 of 8 pages
<PAGE>   5


ITEM 1.

     On April 6, 1999, Matritech, Inc. (the "Issuer") sold 3,094,965 shares of
its Common Stock to certain persons in a private placement transaction,
including 2,325,581 shares to Zero Stage Capital VI Limited Partnership (the
"Fund"). As a result of that transaction, the general partner of the Fund, Zero
Stage Capital Associates VI, LLC (the "General Partner"), became the "beneficial
owner" (as defined in Rule 13d-3 of Regulation 13D-G under the Securities
Exchange Act of 1934) of 10.7% of the outstanding shares of Common Stock of the
Issuer. Between September 13, 1999 and November 29, 1999, the General Partner
sold on behalf of the Fund an aggregate of 1,000,000 shares, as follows:

- --------------------------------------------------------------------------------
DATE               NUMBER OF SHARES                       PRICE PER SHARE
- --------------------------------------------------------------------------------
9/13/99             85,000                                $2.6544
- --------------------------------------------------------------------------------
10/1/99            395,000                                $2.7000
- --------------------------------------------------------------------------------
10/4/99             75,000                                $2.6250
- --------------------------------------------------------------------------------
10/13/99            80,000                                $2.6250
- --------------------------------------------------------------------------------
11/10/99            75,000                                $2.6250
- --------------------------------------------------------------------------------
11/11/99            50,000                                $2.6250
- --------------------------------------------------------------------------------
11/26/99            55,000                                $2.6250
- --------------------------------------------------------------------------------
11/29/99           185,000                                $2.6250
- --------------------------------------------------------------------------------

The sale of the above shares reduces the Fund's beneficial ownership percentage
to 6.10%.

       (a)      NAME OF ISSUER

                Matritech, Inc.

       (b)      ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES

                330 Nevada Street
                Newton, Massachusetts  02400

ITEM 2.

       (a), (b), and (c)

                The reporting persons are:

                (1) Zero Stage Capital Co., Inc., a Massachusetts corporation
                    (the "Management Company")

                (2) Zero Stage Capital Associates VI, LLC, a Massachusetts
                    limited liability company

                (3) Zero Stage Capital VI Limited Partnership, a Massachusetts
                    limited partnership


                               Page 5 of 8 pages

<PAGE>   6

             The address for each of the reporting persons is:

             17th Floor
             101 Main Street
             Kendall Square
             Cambridge, MA  02142

       (d)   TITLE OF CLASS OF SECURITIES

             Common Stock, $.01 par value

       (e)   CUSIP NUMBER

                  576818108
ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO RULE 13D-1(b) OR 13D-2(b), CHECK
WHETHER THE PERSON FILING IS A:

       Not applicable.

ITEM 4. OWNERSHIP

       (a)    AMOUNT BENEFICIALLY OWNED

              (1) The Management Company is a venture capital management
              firm which directly or indirectly provides management services
              and investment advice to venture capital funds, including the
              Fund. The principals of the Management Company disclaim all
              beneficial ownership of all of the shares held by the Fund.

              (2) The General Partner exercises sole voting and investment
              power with respect to the shares held by the Fund.

              (3) The Fund is the record and economic owner of the 1,325,581
              shares, but the exercise of voting and dispositive power is in
              the General Partner.

       (b)    PERCENT OF CLASS

                  6.10%

       (c)    NUMBER OF SHARES AS TO WHICH SUCH PERSON HAS:

             (i)    SOLE POWER TO VOTE OR TO DIRECT THE VOTE

                    Fund: -0- shares
                    General Partner: -1,325,581- shares
                    Management Company: -0- shares


                               Page 6 of 8 pages
<PAGE>   7


             (ii)   SHARED POWER TO VOTE OR TO DIRECT THE VOTE

                    Fund, General Partner and Management Company: -0- shares --
                    But please also refer to Item 4 (a).

             (iii)  SOLE POWER TO DISPOSE OR TO DIRECT THE DISPOSITION OF

                    Fund: -0- shares
                    General Partner: -1,325,581- shares
                    Management Company: -0- shares

             (iv)   SHARED POWER TO DISPOSE OR TO DIRECT THE DISPOSITION OF

                    Fund, General Partner and Management Company: -0- shares
                    -- But please also refer to Item 4 (a).

ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

         Not applicable.

ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

         Not applicable.

ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

         Not applicable.

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

         Not applicable.

ITEM 9.  NOTICE OF DISSOLUTION OF GROUP

         Not applicable.

ITEM 10. CERTIFICATION

     By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and were not acquired and are not
held in connection with or as a participant in any transaction having that
purpose or effect.

                               Page 7 of 8 pages

<PAGE>   8



                                    SIGNATURE

         After reasonable inquiry and to the best of its knowledge and belief,
the undersigned certifies that the information set forth in this statement is
true, complete and correct.


                                    Date:  February 11, 2000

                                    ZERO STAGE CAPITAL CO., INC.

                                    By: /s/ PAUL M. KELLEY
                                       ----------------------------------------
                                       Name:  Paul M. Kelley
                                       Title:  Manager

                                     ZERO STAGE CAPITAL ASSOCIATES VI, LLC

                                     By: /s/ PAUL M. KELLEY
                                        ---------------------------------------
                                        Name:  Paul M. Kelley
                                        Title:  Manager

                                     ZERO STAGE CAPITAL VI LIMITED PARTNERSHIP
                                     By: Zero Stage Capital Associates VI, LLC,
                                         its general partner

                                     By: /s/ PAUL M. KELLEY
                                        ---------------------------------------
                                        Name:  Paul M. Kelley
                                        Title: Manager



                               Page 8 of 8 pages




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