MATRITECH INC/DE/
424B3, 2000-11-29
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1
                                              FINAL PROSPECTUS FILED PURSUANT TO
                                                                  RULE 424(b)(3)
                                                      REGISTRATION NO. 333-44506



                                MATRITECH, INC.
                                 450,000 SHARES
                                OF COMMON STOCK
                            $.01 PAR VALUE PER SHARE
                                ---------------



     This prospectus covers the resale of up to 450,000 shares of our common
stock by the selling securityholders listed inside.

     Our common stock is quoted on the Nasdaq National Market under the symbol
"NMPS." On November 17, 2000, the last reported sale price for our common stock
as reported by the Nasdaq National Market was $4.875 per share. Our executive
offices are located at 330 Nevada Street, Newton, Massachusetts 02460, and our
telephone number is (617) 928-0820.


     SEE "RISK FACTORS" BEGINNING ON PAGE 3 FOR INFORMATION THAT SHOULD BE
CONSIDERED BEFORE INVESTING.

                                ---------------


     NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS
PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.

                                ---------------

               THE DATE OF THIS PROSPECTUS IS NOVEMBER 29, 2000.

<PAGE>   2
                               -----------------
                               TABLE OF CONTENTS
                               -----------------

                                                           Page

Matritech, Inc...........................................    3
Risk Factors.............................................    3
Use of Proceeds..........................................   10
Selling Securityholders..................................   10
Plan of Distribution.....................................   12
Legal Matters............................................   13
Experts..................................................   13
Where You Can Find More Information......................   14
Documents Incorporated by Reference......................   14



                                      -2-
<PAGE>   3

                                MATRITECH, INC.

     We develop, manufacture and market innovative cancer diagnostic products
based on our proprietary nuclear matrix protein technology. The nuclear matrix,
a three-dimensional protein framework within the nucleus of cells, plays a
fundamental role in determining cell type by physically organizing the contents
of the nucleus, including DNA. We have demonstrated that there are differences
in the types and amounts of nuclear matrix proteins found in cancerous and
normal cells. We believe that the detection of these differences in nuclear
matrix proteins, often called NMPs, provides important diagnostic information
about cellular abnormalities, including cancer. Using our proprietary nuclear
matrix protein technology and expertise, we have developed non-invasive or
minimally invasive cancer diagnostic tests for bladder and colon cancer and are
developing additional tests for cervical, breast and prostate cancer. Through
our European subsidiary, we distribute other diagnostic products in Europe.

                                  RISK FACTORS

     An investment in the shares involves a high degree of risk. You should
carefully consider the following risk factors, along with the detailed
information in this prospectus. Please keep these risks in mind when reading
this prospectus, including any forward-looking statements appearing in this
prospectus. If any of the following risks actually occurs, our business, results
of operations and financial condition would likely suffer, and you may lose all
or part of your investment.


     IF WE FAIL TO OBTAIN THE CAPITAL NEEDED TO FUND OUR OPERATIONS, WE MAY BE
UNABLE TO CONDUCT OUR BUSINESS AS PLANNED, TO PURSUE DESIRABLE MARKETS FOR OUR
CURRENT PRODUCTS OR TO DEVELOP AND MARKET NEW PRODUCTS.

     We will need additional funding to continue to market our NMP22(R) Bladder
Cancer Test Kit, to conduct research and development, to conduct clinical
trials, and to manufacture and market our products as we currently contemplate.
At this time, we are unable to determine the amount of additional funding we
will need because this amount will depend on several variables that affect our
capital needs, including the results of clinical trials, the actions of
regulatory agencies like the Food and Drug Administration, the FDA, and market
acceptance of our products and resulting revenue streams. In seeking to raise
additional capital, we will consider various financing alternatives, including
equity or debt financings and corporate partnering arrangements. However, we may
not be able to raise needed capital on terms that are acceptable to us, or at
all. If we do not receive additional financing, we may be required to curtail
further our expenses or take other steps that could hurt our future performance.

     BECAUSE OUR STOCK PRICE MAY BE VOLATILE, THE SHARES HELD BY YOU MAY LOSE
THEIR VALUE RAPIDLY.

     The market price of our common stock has been, and may continue to be,
highly volatile. This price has ranged between $19.375 and $1.875 in the
fifty-two week period prior to October 31, 2000. The stock market has from time
to time experienced extreme price and volume fluctuations, particularly in the
biotechnology sector. These factors have often been unrelated to the operating
performance of particular companies. Factors such as announcements of
technological innovations or new products by our competitors or disappointing
results by third parties, as well as market conditions in our industry, may
significantly impact the market price of our common stock. For example, in the
past our stock price has been affected by announcements of clinical results,
clinical or technical breakthroughs or earnings by other biotechnology companies
unrelated to us or our performance. Our stock price has also been affected by
announcements of developments at Matritech. For example, our stock price has, in
the past, reacted to announcements regarding a delay of our regulatory approval
process for a new product,


                                      -3-
<PAGE>   4

fluctuating sales results and decreasing balances of funds in the corporate
treasury. Thus, as a result of events at Matritech or in our industry, shares of
our common stock could lose their value rapidly.

     OUR COMMON STOCK MAY BE DELISTED FROM THE NASDAQ NATIONAL MARKET, WHICH
WOULD MAKE IT MORE DIFFICULT FOR YOU TO SELL SHARES.

     Our common stock is currently listed on the Nasdaq National Market. For
continued listing of our common stock on the Nasdaq National Market, we must,
among other things, maintain at least $4 million in net tangible assets and a
minimum bid price for our common stock of $1.00. If our net tangible assets fall
below $4 million, or if our common stock trades at a price of less than $1.00
for 30 consecutive business days or more, our shares may be delisted from the
Nasdaq National Market, and trading, if any, would then be conducted in a
non-Nasdaq over-the-counter market. If our shares are delisted, it could be more
difficult for you to sell them or to obtain accurate price information. In
addition, if our shares are delisted, they may be subject to a rule that imposes
additional sales practice requirements on broker-dealers who sell our shares to
persons other than established customers and accredited investors. For
transactions covered by this rule, the broker-dealer must make a special
suitability determination for the purchaser and must have received the
purchaser's written consent to the transaction prior to sale. Consequently,
delisting, if it occurred, may reduce the ability of broker-dealers to sell our
shares and your ability to sell your shares. We do not anticipate that our net
tangible assets will fall below $4 million before December 31, 2000.

     IF WE ARE UNABLE TO MARKET AND DEVELOP OUR PRODUCTS, WE WILL CONTINUE TO
INCUR OPERATING LOSSES AND INVESTORS MAY LOSE INTEREST IN OUR SHARES AND THEIR
MARKET VALUE MAY FALL.

     We have incurred operating losses since we began operations in 1987. These
losses have resulted principally from costs incurred in research and development
and from selling, general and administrative costs associated with our
development. These costs have exceeded our revenues, which to date have been
generated primarily from initial sales of our NMP22 Bladder Cancer Test Kit, our
development agreements, government grants and interest income. We expect to
incur continuing operating losses in the near term. Our ability to be profitable
depends in part on our ability to market our existing products, obtain required
regulatory approvals and develop new products. We may not be able to market
successfully our existing products, obtain required regulatory approvals or
develop, commercialize, produce and market our future products or achieve or
maintain profitability.

     IF OUR NMP22 BLADDER CANCER TEST KIT DOES NOT ACHIEVE WIDE MARKET
ACCEPTANCE, WE WILL LOSE SIGNIFICANT NEAR-TERM PRODUCT SALES OR REVENUES.

     We expect to generate a significant share of all of our near-term product
sales from the sale of our NMP22 Bladder Cancer Test Kits, which were cleared
for sale in the United States by the FDA in 1996, in Japan by the Koseisho in
1998 and in the People's Republic of China by the State Drug Administration in
1999. Our results of operations may suffer if the NMP22 Bladder Cancer Test Kit
does not achieve wide market acceptance because NMP22 is a major source of our
sales revenue. The remainder of our NMP products still require FDA approval or
are in development and do not result in significant revenues.

     IF OUR DISTRIBUTORS DO NOT SUCCESSFULLY SELL OUR PRODUCTS, OUR SALES
REVENUE WILL SUFFER.

     We have limited internal marketing and sales resources and personnel. We
derive a significant portion of our sales revenue from distribution agreements
with two distributors. Konica Corporation has an exclusive right to sell our
NMP22 Bladder Cancer Test Kit in Japan. Fisher Diagnostics has a co-


                                      -4-
<PAGE>   5

exclusive right with us to sell our NMP22 Bladder Cancer Test Kit to hospitals
and commercial laboratories in the United States. In addition, General
Biologicals Corporation has the right to sell our NMP22 Bladder Cancer Test in
connection with an annual screening program in Taiwan. Because we do not deal
directly with customers when selling through distributors, we depend on the
ability of Konica and Fisher and, to a lesser extent, General Biologicals, to
market actively, to forecast demand accurately and to maintain appropriate
levels of inventory. We have minimal control over our distributors, and these
distributors are under no obligation to fulfill their commitment to purchase a
set quantity of our products. If any of our distributors fails to sell our
products or breaches their agreements with us, we could experience a significant
reduction in our revenues. We may be unable to enter into additional
distribution relationships on favorable terms, if at all. These events could
reduce anticipated future sales growth.

     OUR OPERATING RESULTS MAY FLUCTUATE SIGNIFICANTLY FROM QUARTER TO QUARTER
AND WILL NOT NECESSARILY INDICATE RESULTS IN FUTURE PERIODS.

     Our future operating results may vary significantly from quarter to quarter
or from year to year for several reasons, including:

     -    the timing and size of orders from customers and distributors;

     -    regulatory approvals and the introduction of new products by us; and

     -    market acceptance of our products.

     We have based our current planned expense levels in part upon expectations
about future revenue. Consequently, operating results may vary significantly
from quarter to quarter or year to year based on the timing of revenue. Revenue
or profits in any period will not necessarily indicate results in subsequent
periods.

     WE FACE INTENSE COMPETITION AND OUR TECHNOLOGY MAY BECOME OBSOLETE.

     Although we are not aware of any other company using nuclear matrix protein
technology to develop diagnostic or therapeutic products, competition in the
development and marketing of cancer diagnostics and therapeutics, using a
variety of technologies, is intense. Many pharmaceutical companies,
biotechnology companies, public and private universities and research
organizations actively engage in the research and development of clinical cancer
diagnostic products. Many of these organizations have greater financial,
manufacturing, marketing and human resources than we do.

     We expect that certain of our clinical tests will compete with existing
FDA-approved clinical tests, including:

     -    a test known as BTA, which has been approved for monitoring bladder
          cancer;

     -    a test known as CEA, which is used primarily for monitoring colorectal
          and breast cancers;

     -    a test known as PSA, which is used primarily for monitoring and
          screening prostate cancer; and


                                      -5-
<PAGE>   6

     -    a test known as TRUQUANT BR RIA, which is used for monitoring breast
          cancer.

     We are also aware of a number of companies exploring the application of
oncogene technology to cancer diagnostics. Our diagnostic products will also
compete with more invasive or expensive procedures such as surgery, bone scans,
magnetic resonance imaging and other in vivo imaging techniques. In addition,
other companies may introduce competing diagnostic products based on other
technologies that may adversely affect our competitive position. As a result,
our products may become obsolete or non-competitive.

     IF WE ARE UNABLE TO DEVELOP AND MARKET FUTURE PRODUCTS, OUR SALES REVENUE
MAY NOT MEET EXPECTATIONS AND OUR STOCK PRICE MAY DROP.

     Other than the NMP22 Bladder Cancer Test Kit and other diagnostic products
distributed by our European subsidiary, all of our products are under
development. We do not expect these products to be commercially available in the
United States for some time. We will need to complete significant additional
research and development, laboratory testing and clinical testing of our
products and obtain regulatory approval for them before we will be able to
commercialize a majority of our products. The development of our products
involves the use of advanced technical methods that require both a high degree
of skill and judgment in their application. We may encounter unexpected
technical difficulties in the course of the development process that we may be
able to overcome only if we expend additional funds and time, if at all. We may
not successfully complete our product development efforts, and we may not obtain
the required regulatory approvals. In addition, we may not be able to
commercialize, produce and market or achieve customer acceptance of our future
products, if any. We believe that the market value of our stock is based in part
on an expectation of future revenue-producing products. If we are unable to
develop and market future products, or if the market believes that we are
experiencing difficulty developing future products, our stock price may drop.
For example, the market reacted negatively when we announced that one of our
products would not receive expedited FDA review.

     GOVERNMENT REGULATION COULD MAKE THE DEVELOPMENT AND SALE OF OUR PRODUCTS
COSTLY AND DIFFICULT.

     The FDA and, in some instances, foreign governments, extensively regulate
the medical devices that we market and manufacture. The FDA regulates the
clinical testing, manufacture, labeling, distribution and promotion of medical
devices in the United States. If we fail to comply with the FDA's requirements,
including Good Manufacturing Practices, we may face a number of consequences,
including:

     -    fines;

     -    injunctions;

     -    civil penalties;

     -    recall or seizure of products;

     -    total or partial suspension of production;

     -    failure of the government to grant premarket clearance or premarket
          approval for devices;


                                      -6-
<PAGE>   7

     -    withdrawal of marketing approvals; and

     -    criminal prosecution.

     The FDA also has the authority to request repair, replacement or refund of
the cost of any device that we manufacture or distribute.

     Any products that we manufacture or distribute in accordance with FDA
clearances or approvals are subject to pervasive and continuing regulation by
the FDA, including:

     -    device manufacturers and distributors are required to comply with
          recordkeeping requirements and to report adverse experiences with the
          use of the device;

     -    device manufacturers are required to register their establishments and
          list their devices with the FDA and are subject to periodic
          inspections by the FDA and certain state agencies; and

     -    devices are required to be manufactured in accordance with Good
          Manufacturing Practices regulations which impose certain procedural
          and documentation requirements on us with respect to manufacturing and
          quality assurance activities.

     Labeling and promotional activities are subject to scrutiny in the United
States by the FDA and, in certain instances, by the Federal Trade Commission.
For example, the NMP22 Bladder Cancer Test Kit has received FDA approval and may
be promoted by us only as a prognostic indicator or as a testing device for use
by previously undiagnosed individuals who have symptoms of or are at risk for
bladder cancer. The FDA actively enforces regulations prohibiting the promotion
of devices for unapproved uses and the promotion of devices for which premarket
clearance or approval has not been obtained. Consequently, we cannot currently
promote the NMP22 Bladder Cancer Test Kit for cancer screening in the United
States or for any other unapproved use. If we fail to comply with these
requirements, we may face regulatory enforcement action by the FDA that would
prevent us from manufacturing or selling our products, hurt our ability to
conduct testing necessary to obtain market clearance for these products and
reduce our potential sales revenues.

     We are also subject to a variety of state laws and regulations in those
states or localities where our products are or will be marketed. Any applicable
state or local regulations may hinder our ability to market our products in
those states or localities. Manufacturers are also subject to numerous federal,
state and local laws relating to such matters as safe working conditions,
manufacturing practices, environmental protection, fire hazard control, and
disposal of hazardous or potentially hazardous substances. We may be required to
incur significant costs to comply with these laws and regulations now or in the
future, which could increase future losses or reduce future profitability.

     IF WE LOSE OUR PROPRIETARY TECHNOLOGY ADVANTAGE, WE COULD BE OVERWHELMED BY
COMPETITORS.

     We rely on a combination of patent, trade secret and trademark laws,
nondisclosure and other contractual provisions and technical measures to protect
the proprietary rights in our current and planned products. These protections
may be inadequate, and our competitors may independently develop technologies
that are substantially equivalent or superior to our technology. Patent law
relating to the scope of claims in the biotechnology field is still evolving
and, therefore, the degree of future protection for our proprietary rights is
uncertain. In addition, the laws of certain countries in which our products are


                                      -7-
<PAGE>   8

or may be licensed or sold do not protect our products and intellectual property
rights to the same extent as the laws of the United States.

     We believe that the use of the patents for nuclear matrix protein
technology licensed to us and the use of our trademarks and other proprietary
rights do not infringe upon the proprietary rights of third parties. However, we
may not prevail in any challenge of third-party intellectual property rights,
and third parties may successfully assert infringement claims against us in the
future. In addition, we may be unable to acquire licenses to any of these
proprietary rights of third parties on reasonable terms.

     HEALTHCARE REFORM MEASURES AND THIRD-PARTY REIMBURSEMENT POLICIES COULD
LIMIT THE PER-PRODUCT REVENUES FOR OUR PRODUCTS.

     Our ability to commercialize successfully our planned products will depend
in part on the extent to which reimbursement for the cost of our products will
be available from government health administration authorities, private health
insurers and other third-party payors. In the case of private insurers, the
reimbursement of any medical device, either approved for investigational use
only or for research use, is at the sole discretion of the patient's individual
carrier. Even if a procedure has been previously approved for reimbursement, the
insurance carrier may decide not to continue to reimburse the procedure.
Further, even if in the future we do successfully sell our products to managed
care providers, it is possible that these sales will involve significant pricing
pressure on our products and keep our per-product revenues low. Healthcare
reform is an area of continuing national attention and a priority of many
governmental officials. Certain reform proposals, if adopted, could impose
limitations on the prices we will be able to charge in the United States for our
products or the amount of reimbursement available for our products from
governmental agencies or third-party payors. While we cannot predict whether any
of these legislative or regulatory proposals will be adopted or the effect that
these proposals may have on our business, the announcement or adoption of these
proposals could hurt our business by reducing demand for our products and could
hurt our stock price because of investor reactions.

     IF WE DO NOT DEVELOP A LARGER MARKETING AND SALES FORCE, WE WILL REMAIN
DEPENDENT ON DISTRIBUTORS, AND WE MAY FAIL TO INCREASE SALES.

     We have limited internal marketing and sales resources and personnel. In
order to market successfully our current and future products in the United
States and other territories in which we do not, or do not intend to, use
third-party distributors, we will need to develop a larger marketing and sales
force with appropriate technical expertise and distribution capability. We may
be unable to establish the marketing and sales capabilities that we need, and we
may be unsuccessful in gaining market acceptance for any of our products.

     IF WE ARE UNABLE TO MANUFACTURE THE PRODUCT VOLUMES WE NEED, WE WILL BE
UNABLE TO ACHIEVE PROFITABILITY.

     We have been manufacturing and assembling our test kits for limited
commercial sales since 1995 but have not yet manufactured the large product
volumes necessary for us to achieve profitability. We may encounter difficulties
in scaling up production of new products, if necessary, including problems
involving:

     -    production yields;


                                      -8-
<PAGE>   9

     -    quality control and assurance;

     -    component supply; and

     -    shortages of qualified personnel.

     These problems could make it very difficult to produce sufficient product
to satisfy customer needs and could result in customer dissatisfaction. We may
not be able to achieve reliable, high-volume manufacturing at a commercially
reasonable cost. In addition, numerous governmental authorities extensively
regulate our manufacturing operations. If we fail to satisfy our manufacturing
needs, we could experience decreased sales, loss of market share and potential
loss of certain distribution rights.

     IF OUR SUPPLIERS CANCEL THEIR AGREEMENTS WITH US, IT MAY BE DIFFICULT FOR
US TO FIND REPLACEMENTS FOR OUR SUPPLIERS.

     We currently rely on sole suppliers for certain key components for our test
kits. If the components from these suppliers should become unavailable for any
reason, we would seek alternative sources of supply. In order to maintain the
FDA validation of our manufacturing process, we would have to show that these
alternative sources of supply are equivalent to our current sources. Although we
attempt to maintain an adequate level of inventory to provide for these and
other contingencies, if our manufacturing processes are disrupted as a result of
a shortage of key components or a revalidation of new components, we may be
unable to meet our commitments to customers. Our failure or delay in meeting our
commitments could cause sales to decrease, market share to be lost permanently,
and could result in significant expenses to obtain alternative sources of supply
with the necessary facilities and know-how.

     IF WE ARE UNABLE TO RETAIN OUR KEY PERSONNEL, WE MAY BE UNABLE TO ACHIEVE
OUR DEVELOPMENTAL OBJECTIVES.

     Our success depends, in large part, upon our ability to attract and retain
a highly qualified scientific and management team. We have no employment
contracts with any of our key personnel. If we lose our key personnel or fail to
recruit the necessary additional personnel we need for a qualified team, we may
be unable to achieve our developmental objectives. We face competition for
qualified personnel from numerous pharmaceutical and biotechnology companies,
research and academic institutions, government entities and other organizations.
Accordingly, we may not be successful in hiring or retaining qualified
scientific or management personnel on terms acceptable to us.

     IF WE ARE SUED FOR PRODUCT-RELATED LIABILITIES, THE COST COULD BE
PROHIBITIVE TO US.

     The testing, marketing and sale of human healthcare products entail an
inherent exposure to product liability, and third parties may successfully
assert product liability claims against us. Although we currently have insurance
covering our products, we may not be able to maintain this insurance at
acceptable costs in the future, if at all. In addition, our insurance may not be
sufficient to cover large claims. If we are sued for significant product-related
issues, we could face large and unexpected expenses in defending those claims.
We may also experience a costly distraction of management resources, potential
negative publicity and reduced demand for our products.


                                      -9-
<PAGE>   10

     OUR ACTIVITIES INVOLVE THE USE OF HAZARDOUS MATERIALS, AND WE MAY BE HELD
LIABLE FOR ANY ACCIDENTAL INJURY FROM THESE HAZARDOUS MATERIALS.

     Our research and development activities involve the controlled use of
hazardous materials, including radioactive compounds. Although we believe that
our safety procedures for handling and disposing of our hazardous materials
comply with the standards prescribed by federal, state and local laws and
regulations, the risk of accidental contamination or injury from these materials
cannot be completely eliminated. In the event of an accident, we could be held
liable for damages that result and significant and unexpected costs, including
costs relating to liabilities and clean-up, costs from increased insurance
premiums or inability to obtain adequate insurance at a reasonable price and
costs from loss of operations during clean-up.

                                USE OF PROCEEDS

     Matritech will receive no part of the proceeds from the sale of any of the
shares by any of the selling securityholders, although we may receive, subject
to anti-dilution adjustments, $2.50 per share upon exercise of the warrants.

                            SELLING SECURITYHOLDERS

     The following table sets forth certain information as of September 30, 2000
with respect to our common stock beneficially owned by each selling
securityholder. The shares may be offered from time to time by any of the
selling securityholders or by those individuals and entities to whom they may
transfer or distribute the shares.

     The persons and entities named in the table below have sole voting and
investment power with respect to all shares shown as beneficially owned by them
based upon information provided to us by the selling securityholders.

     In calculating the number of shares beneficially owned by each selling
securityholder after the offering, we have assumed that the selling
securityholders will sell all of the shares of common stock registered under
this prospectus. The selling securityholders may sell all or any part of their
shares registered under this prospectus.

     Beneficial ownership is determined in accordance with the rules of the
Securities and Exchange Commission. Shares of common stock issuable by us to a
person pursuant to options or warrants which may be exercised within 60 days of
September 30, 2000 are deemed to be beneficially owned and outstanding for
purposes of calculating the number of shares and the percentage beneficially
owned by that person. However, these shares are not deemed to be beneficially
owned and outstanding for purposes of computing the percentage beneficially
owned by any other person.

     In calculating the percentage of shares beneficially owned by each selling
securityholder prior to and after the offering, we have based our calculations
on the number of shares of common stock deemed outstanding as of September 30,
2000, which includes:

     -    25,096,974 shares of common stock outstanding as of September 30,
          2000; and

     -    all shares of common stock issuable upon the exercise of options and
          warrants which may be exercised by that selling securityholder within
          60 days of September 30, 2000.


                                      -10-
<PAGE>   11

<TABLE>
<CAPTION>
---------------------------------------------------------------------------------------
                                 Number of            Number of      Number of Shares
                         Shares Beneficially Owned     Shares       Beneficially Owned
                             Prior to Offering         Offered        After Offering
                         -------------------------    ---------     ------------------
Name and Address (1)        Number       Percent                    Number     Percent
--------------------        -------      -------                    ------     -------
<S>                         <C>          <C>           <C>          <C>        <C>
Derek Caldwell (2)          200,000         *          200,000         0          *
Sean Gallagher (3)           15,000         *           15,000         0          *
Nathan Low (4)              200,000         *          200,000         0          *
D. Dwight Miller (5)         40,637         *           15,000      25,637        *
Marc Seelenfreund (6)        15,000         *           15,000         0          *
Matthew Toole (7)             5,000         *            5,000         0          *

TOTAL                       475,637         *          450,000      25,637        *
---------------------------------------------------------------------------------------
</TABLE>

*Less than 1%


(1)  The address of each person listed on the table is c/o Sunrise Securities
     Corp., 135 E. 57th Street, 11th Floor, New York, NY.

(2)  Mr. Caldwell's beneficial ownership includes 200,000 shares of common stock
     issuable upon exercise of warrants.

(3)  Mr. Gallagher's beneficial ownership includes 15,000 shares of common stock
     issuable upon exercise of warrants.

(4)  Mr. Low's beneficial ownership includes 200,000 shares of common stock
     issuable upon exercise of warrants.

(5)  Mr. Miller's beneficial ownership includes 40,637 shares of common stock
     issuable upon exercise of warrants.

(6)  Mr. Seelenfreund's beneficial ownership includes 15,000 shares of common
     stock issuable upon exercise of warrants.

(7)  Mr. Toole's beneficial ownership includes 5,000 shares of common stock
     issuable upon exercise of warrants.

     The selling securityholders acquired the shares of common stock offered
under this prospectus from Matritech through the exercise of the warrants to
purchase our common stock issued in a private placement of warrants to purchase
450,000 shares of common stock, which was completed on July 14, 2000.

     Mr. Low is the sole shareholder of Sunrise Securities Corp., and Messrs.
Caldwell, Gallagher, Miller, Seelenfreund, and Toole are employees of Sunrise
Securities Corp. Mr. Low is also the sole shareholder of Sunrise Financial
Group, Inc., which currently acts as an investor relations consultant to us. Mr.
Caldwell is also an employee of Sunrise Financial Group, Inc.


                                      -11-
<PAGE>   12

                              PLAN OF DISTRIBUTION

     The shares of common stock offered under this prospectus may be sold from
time to time by or for the account of any of the selling securityholders or by
those individuals and entities to whom they pledge, donate, distribute or
transfer their shares or other successors in interest.

     We will not receive any of the proceeds from the sale of these shares by
the selling securityholders, although we may receive, subject to anti-dilution
adjustments, $2.50 per share upon exercise of the warrants.

     The distribution of the shares of common stock offered under this
prospectus by the selling securityholders is not subject to any underwriting
agreement. The shares may be sold under this prospectus directly to purchasers
by the selling securityholders:

     -    in negotiated transactions;

     -    by or through brokers or dealers in ordinary brokerage transactions or
          transactions in which the broker solicits purchasers;

     -    in block trades in which the broker or dealer will attempt to sell the
          shares as agent but may position and resell a portion of the block as
          principal;

     -    in transactions in which a broker or dealer purchases as principal for
          resale for its own account; or

     -    through underwriters or agents.

     The shares of common stock offered under this prospectus may be sold at a
fixed offering price, which may be changed, at the prevailing market price at
the time of sale, at prices related to the prevailing market price or at
negotiated prices. Any brokers, dealers, underwriters or agents may arrange for
others to participate in any of these transactions and may receive compensation
in the form of discounts, commissions or concessions from the selling
securityholders and/or the purchasers of the shares. Each selling securityholder
will be responsible for payment of any and all commissions to brokers. We have
agreed to indemnify the selling securityholders against certain liabilities,
including liabilities under the Securities Act of 1933 and the Securities
Exchange Act of 1934.

     The selling securityholder may also loan or pledge the shares registered
under this prospectus to a broker-dealer and the broker-dealer may sell the
shares so loaned or upon a default the broker-dealer may effect sales of the
pledged shares using this prospectus.

     In connection with the private placement which was completed on July 14,
2000, we executed an investor relations warrant agreement with each of the
selling securityholders in which we agreed to file the registration statement to
which this prospectus is a part and to take certain other actions to permit the
selling securityholders to sell the shares of common stock offered under this
prospectus under the Securities Act of 1933 and applicable state securities
laws.

     In order to comply with the securities laws of individual states, if
applicable, the shares of common stock offered under this prospectus will be
sold in those jurisdictions only through registered or licensed brokers or
dealers. In addition, in certain states these shares may not be sold unless they
have


                                      -12-
<PAGE>   13

been registered or qualified for sale in the applicable state or an exemption
from the registration or qualification requirement is available and is complied
with.

     If and when any of the shares covered by this prospectus qualifies for sale
under Rule 144 under the Securities Act of 1933, they may be sold under Rule 144
rather than under this prospectus.

     Any selling securityholder and any broker-dealer, agent or underwriter that
participates with the selling securityholder in the distribution of the shares
of common stock offered under this prospectus may be considered to be
"underwriters" within the meaning of the Securities Act of 1933, in which event
any commissions received by those broker-dealers, agents or underwriters and any
profit on the resale of the shares purchased by them may be considered to be
underwriting commissions or discounts under the Securities Act of 1933.

     The selling securityholders are not restricted as to the price or prices at
which they may sell the shares of common stock offered under this prospectus.
Sales of shares at less than the market price may depress the market price of
our securities. Moreover, the selling securityholders are not restricted as to
the number of shares which may be sold at any one time, and it is possible that
a significant number of shares could be sold at the same time which may also
depress the market price of our securities.

     Under applicable rules and regulations under the Securities Exchange Act of
1934, any person engaged in the distribution of the shares of common stock
offered under this prospectus may not simultaneously engage in market making
activities with respect to the shares for a period of time prior to the
commencement of the distribution. In addition, each selling securityholder will
be subject to applicable provisions of the Securities Exchange Act of 1934 and
the rules and regulations under the Securities Exchange Act of 1934, including,
but not limited to, Rule 10b-5 and Regulation M, which provisions may limit the
timing of purchases and sales of the shares by the selling securityholder.

     There is no assurance that any selling securityholder will sell any or all
of the shares described in this prospectus and may transfer, devise or gift
these securities by other means not described in this prospectus.

     We are permitted to suspend the use of this prospectus in connection with
sales of the shares of our common stock offered under this prospectus by holders
during periods of time under certain circumstances relating to pending corporate
developments and public filings with the Securities and Exchange Commission and
similar events.

                                 LEGAL MATTERS

     Several legal matters with respect to the shares of common stock offered
under this prospectus will be passed upon for us by Testa, Hurwitz & Thibeault,
LLP, Boston, Massachusetts.

                                    EXPERTS

     The audited financial statements incorporated by reference in this
prospectus and elsewhere in the registration statement have been audited by
Arthur Andersen LLP, independent public accountants, as indicated in their
reports with respect thereto, and are included herein in reliance upon the
authority of said firm as experts in giving said reports.


                                      -13-
<PAGE>   14

                      WHERE YOU CAN FIND MORE INFORMATION

     We are subject to the informational requirements of the Securities Exchange
Act of 1934, and in accordance with those requirements files reports, proxy
statements and other information with the Securities and Exchange Commission.
The reports, proxy statements and other information that we file with the SEC
under the informational requirements of the Securities Exchange Act of 1934 may
be obtained from the SEC's Public Reference Section at 450 Fifth Street, N.W.,
Washington, D.C. 20549 at prescribed rates. Please call 1-800-SEC-0330 for
information about the SEC's Public Reference Room. Our common stock is traded on
the Nasdaq National Market, and the reports, proxy statements and other
information that we file with the SEC may also be inspected at the offices of
The Nasdaq Stock Market, Inc., Reports Section, 1735 K Street, N.W., Washington,
D.C. 20006.

     The Commission also maintains a Web site that contains reports, proxy and
information statements and other information regarding registrants that file
electronically with the Commission. The address of the Commission's Web site is
http: //www.sec.gov.

     We have filed with the Commission a registration statement on Form S-3,
including all amendments to the registration statement under the Securities Act
of 1933 with respect to the shares of common stock offered under this
prospectus. This prospectus does not contain all of the information set forth in
the registration statement, certain parts of which are omitted in accordance
with the rules and regulations of the Commission. For further information
regarding us and the shares offered under this prospectus, please see the
registration statement and the exhibits and schedules filed with the
registration statement. Statements contained in this prospectus regarding the
contents of any agreement or other document filed as an exhibit to the
registration statement are not necessarily complete, and in each instance please
see the copy of the full agreement filed as an exhibit to the registration
statement. We qualify each of these statements in all respects by the reference
to the full agreement. The registration statement, including the exhibits and
schedules to the registration statement, may be inspected at the public
reference facilities maintained by the Commission at 450 Fifth Street, N.W.,
Washington, D.C. 20549 and copies of all or any part of the registration
statement may be obtained from the Commission's office upon payment of the
prescribed fees.

                      DOCUMENTS INCORPORATED BY REFERENCE

     The SEC allows us to "incorporate by reference" the information we file
with them, which means that we can disclose important information to you by
referring you to those documents. The following documents filed by us with the
Commission, File No. 001-12128, are incorporated by reference in this
prospectus, except as superseded or modified by this prospectus:

1.   Our annual report on Form 10-K for the fiscal year ended December 31, 1999,
     filed under the Exchange Act, which contains audited financial statements
     for the fiscal year ended December 31, 1999.

2.   Our quarterly report on Form 10-Q for the fiscal quarter ended March 31,
     2000 filed under the Exchange Act, which contains unaudited financial
     statements for the fiscal quarter ended March 31, 2000.

3.   Our quarterly report on Form 10-Q for the fiscal quarter ended June 30,
     2000 filed under the Exchange Act, which contains unaudited financial
     statements for the fiscal quarter ended June 30, 2000.

4.   Our quarterly report on Form 10-Q for the fiscal quarter ended September
     30, 2000 filed under the Exchange Act, which contains unaudited financial
     statements for the fiscal quarter ended September 30, 2000.

                                      -14-
<PAGE>   15

5.   Our current report on Form 8-K dated June 28, 2000.

6.   Our current report on Form 8-K dated August 24, 2000.

7.   The description of our common stock, $.01 par value per share, contained in
     the section entitled "Description of Registrant's Securities to be
     Registered" contained in our registration statement on Form 8-A filed with
     the Commission on March 10, 1992, including any amendment or report filed
     for the purpose of updating the description of our common stock.

     All documents filed by us under Sections 13(a), 13(c), 14 or 15(d) of the
Securities Exchange Act of 1934 after the date of this prospectus and prior to
the termination of the offering made under this prospectus are incorporated by
reference in this prospectus and made a part of this prospectus from the date we
file the documents with the SEC. Any statement contained in this prospectus or
in a document incorporated or deemed to be incorporated by reference in this
prospectus shall be deemed to be modified or superseded for purposes of this
prospectus to the extent that a statement contained in this prospectus or in any
other subsequently filed document which also is or is deemed to be incorporated
by reference in this prospectus modifies or supersedes such statement. Any
statement so modified or superseded shall not be deemed, except as so modified
or superseded, to constitute a part of this prospectus. We will provide without
charge to each person, including any beneficial owner, to whom this prospectus
is delivered, upon the written or oral request of that person, a copy of any
document incorporated in this prospectus by reference other than exhibits unless
those exhibits are specifically incorporated by reference into the documents.
Requests for these copies should be directed to Matritech, Inc., Attention: John
S. Doherty, Jr., Chief Financial Officer, 330 Nevada Street, Newton,
Massachusetts 02460, telephone (617) 928-0820.


                                      -15-
<PAGE>   16

================================================================================

You should rely only on the information contained in this prospectus or
information specifically incorporated by reference in this prospectus. We have
not authorized anyone to provide you with information that is different. Neither
the delivery of this prospectus, nor any sale made hereunder, shall create any
implication that the information in this prospectus is correct after the date
hereof. This prospectus is not an offer to or solicitation of any person in any
jurisdiction in which such offer or solicitation is illegal.

                      ----------------------------
                           TABLE OF CONTENTS
                      ----------------------------
            Matritech, Inc.........................   3
            Risk Factors...........................   3
            Use of Proceeds........................  10
            Selling Securityholders................  10
            Plan of Distribution...................  12
            Legal Matters..........................  13
            Experts................................  13
            Where You Can Find More
            Information............................  14
            Documents Incorporated by
            Reference..............................  14


                                 450,000 SHARES

                                       OF

                                  COMMON STOCK

                                       OF

                                 MATRITECH, INC.

================================================================================

                               November 29, 2000


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