SUNPHARM CORPORATION
S-8, 1997-12-11
PHARMACEUTICAL PREPARATIONS
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    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON DECEMBER 10, 1997

                                                           REGISTRATION NO. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                           ---------------------------


                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                              SUNPHARM CORPORATION
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)


               DELAWARE                                        F593097048
    (STATE OR OTHER JURISDICTION OF                         (I.R.S. EMPLOYER
    INCORPORATION OR ORGANIZATION)                        IDENTIFICATION NO.)

    4651 SALISBURY ROAD, SUITE 205
      JACKSONVILLE, FLORIDA 32256                                32256
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)                       (ZIP CODE)

                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN

                     AMENDED AND RESTATED 1995 NON-EMPLOYEE
                          DIRECTORS' STOCK OPTION PLAN
                            (FULL TITLE OF THE PLAN)

                                   STEFAN BORG
                      PRESIDENT AND CHIEF EXECUTIVE OFFICER
                              SUNPHARM CORPORATION
                         4651 SALISBURY ROAD, SUITE 205
                           JACKSONVILLE, FLORIDA 32256
                     (NAME AND ADDRESS OF AGENT FOR SERVICE)

                                 (904) 296-3320
          (TELEPHONE NUMBER, INCLUDING AREA CODE, OF AGENT FOR SERVICE)

                           ---------------------------

                                    COPY TO:
                                 JEFFREY L. WADE
                             ANDREWS & KURTH L.L.P.
                        2170 BUCKTHORNE PLACE, SUITE 150
                           THE WOODLANDS, TEXAS 77380
                                 (713) 220-4801

                           ---------------------------


                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>

====================================================================================================================================
                                                                    PROPOSED MAXIMUM         PROPOSED MAXIMUM
                                                   AMOUNT TO         OFFERING PRICE             AGGREGATE              AMOUNT OF
    TITLE OF SECURITIES TO BE REGISTERED         BE REGISTERED        PER SHARE(1)          OFFERING PRICE(1)      REGISTRATION FEE
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                       <C>                  <C>                      <C>                   <C>                       <C>   
  Common Stock, par value $.0001 per share     1,050,000 Shares         $5.53(1)              $5,806,500(1)             $1,760
====================================================================================================================================
</TABLE>

(1)      Estimated  solely for the purpose of calculating the  registration  fee
         pursuant to Rule 457(c) and (h), based upon the average of the high and
         low sales prices of a share of the Company's Common Stock on The Nasdaq
         Small Cap Market on December 8, 1997.

<PAGE>

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


ITEM 3.  INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE.

                  SunPharm  Corporation (the "Company")  incorporates  herein by
reference the following documents as of their respective dates as filed with the
Securities and Exchange Commission (the "Commission"):

                  (a)      The  Company's  Annual  Report on Form 10-KSB for the
                           year ended December 31, 1996;

                  (b)      The  Company's  Quarterly  Reports on Form 10-QSB for
                           the quarters ended March 31, 1997,  June 30, 1997 and
                           September 30, 1997;

                  (c)      The Company's  Current  Report on Form 8-K filed with
                           the Commission on April 14, 1997;

                  (d)      The  description of the Company's  common stock,  par
                           value   $.0001  per  share  (the   "Common   Stock"),
                           contained in the Company's  Registration Statement on
                           Form 8-A filed with the  Commission  on  January  18,
                           1996  pursuant  to  Section  12  of  the   Securities
                           Exchange  Act of  1934,  as  amended  (the  "Exchange
                           Act").

                  All documents filed by the Company  pursuant to Section 13(a),
13(c),  14 and 15(d) of the  Exchange  Act  after the date of this  Registration
Statement and prior to the filing of a post-effective  amendment which indicates
that all securities  offered hereby have been sold or which deregisters all such
securities then remaining unsold shall be deemed to be incorporated by reference
in this  Registration  Statement and to be a part hereof from the date of filing
such documents.

ITEM 4.  DESCRIPTION OF SECURITIES.

                  The  information  required by Item 4 is not applicable to this
Registration  Statement  because  the  class  of  securities  to be  offered  is
registered under Section 12 of the Exchange Act.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

                  The  information  required by Item 5 is not applicable to this
Registration Statement.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

                  Section 145 of the Delaware  General  Corporation  Law,  INTER
ALIA,  empowers a Delaware  corporation  to indemnify any person who was or is a
party  or is  threatened  to be  made a  party  to any  threatened,  pending  or
completed action, suit or proceeding (other than an action by or in the right of
the  corporation)  by reason of the fact that such  person is or was a director,
officer,  employee  or  agent of the  corporation  or is or was  serving  at the
request of the corporation as a director,  officer, employee or agent of another
corporation or other enterprise,  against expenses (including  attorneys' fees),
judgments, fines and amounts paid in settlement actually and reasonably incurred
by him in  connection  with such action,  suit or proceeding if he acted in good
faith and in a manner he reasonably believed to be in or not opposed to the best
interests  of the  corporation,  and,  with  respect to any  criminal  action or
proceeding, had no reasonable cause to believe his conduct was unlawful. Similar
indemnity is authorized for such persons against expenses (including  attorneys'
fees)  actually  and  reasonably  incurred  in  connection  with the  defense or
settlement of any such  threatened,  pending or completed action or suit if such
person  acted in good faith and in a manner he  reasonably  believed to be in or
not opposed to the best interests of the corporation,  and provided further that
(unless a court of competent  jurisdiction otherwise provides) such person shall
not have been adjudged liable to the corporation.  Any such  indemnification may
be made only as authorized in each specific case upon a determination by the

                                      II-1
<PAGE>

stockholders  or  disinterested  directors or by independent  legal counsel in a
written  opinion that  indemnification  is proper because the indemnitee has met
the applicable standard of conduct.

                  Section 145 further  authorizes a corporation  to purchase and
maintain  insurance  on behalf of any person who is or was a director,  officer,
employee or agent of the corporation, or is or was serving at the request of the
corporation as a director,  officer, employee or agent of another corporation or
enterprise,  against any liability  asserted  against him and incurred by him in
any such  capacity,  or arising  out of his  status as such,  whether or not the
corporation  would  otherwise have the power to indemnify him under Section 145.
The Company  maintains  policies  insuring its officers  and  directors  against
certain liabilities for actions taken in such capacities,  including liabilities
under the Securities Act of 1933.

                  Article   VII   of   the   Company's   Bylaws   provides   for
indemnification  of the directors and officers of the Company to the full extent
permitted by law, as now in effect or later amended.

                  Article VIII of the  Company's  Certificate  of  Incorporation
limits under certain  circumstances the liability of the Company's directors for
a breach of their fiduciary duty as directors. These provisions do not eliminate
the liability of a director (i) for a breach of the  director's  duty of loyalty
to the Company or its stockholders, (ii) for acts or omissions not in good faith
or which involve  intentional  misconduct or a knowing  violation of law,  (iii)
under  Section 174 of the  Delaware  General  Corporation  Law  (relating to the
declaration  of dividends  and purchase or  redemption of shares in violation of
the Delaware General Corporation Law) or (iv) for any transaction from which the
director derived an improper personal benefit.

                  Article  IX of  the  Company's  Certificate  of  Incorporation
provides that the Company shall, to the maximum extent  permitted under Delaware
law,  indemnify and upon request shall advance  expenses to any person who is or
was a party or is  threatened to be made a party to any  threatened,  pending or
completed action, suit or proceeding, whether civil, criminal, administrative or
investigative,  by reason  of the fact  that he is or was or has  agreed to be a
director  or  officer of the  Company  or while a director  or officer is or was
serving at the request of the Company as a director,  officer, partner, trustee,
employee or agent of any corporation, partnership, joint venture, trust or other
enterprise,  against expenses,  judgments,  fines, penalties and amounts paid in
settlement  or incurred in connection  with the  investigation,  preparation  to
defend or  defense  of such  action,  suit,  proceeding,  claim or  counterclaim
initiated by or on behalf of such person.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

                  The  information  required by Item 7 is not applicable to this
Registration Statement.

ITEM 8.  EXHIBITS.

EXHIBIT NO.                                   DESCRIPTION
                                              -----------

      4.1        --     Certificate of Incorporation  (incorporated by reference
                        to Exhibit 3.1 to the Company's  Registration  Statement
                        on Form SB-2 (Registration No. 33-85416-A)).
      4.2        --     Bylaws  (incorporated by reference to Exhibit 3.2 to the
                        Company's    Registration   Statement   on   Form   SB-2
                        (Registration No. 33-85416-A)).
      4.3        --     Specimen  Common  Stock  Certificate   (incorporated  by
                        reference  to  Exhibit  4.1 to  Amendment  No.  2 to the
                        Company's    Registration   Statement   on   Form   SB-2
                        (Registration No. 33-85416-A)).
      5.1*       --     Opinion of Andrews & Kurth L.L.P.  as to the legality of
                        the securities being registered.
     23.1*       --     Consent of Deloitte & Touche LLP.

                                      II-2
<PAGE>

EXHIBIT NO.                                   DESCRIPTION
                                              -----------

     23.2*       --     Consent  of  Andrews  & Kurth  L.L.P.  (included  in the
                        opinion  filed  as  Exhibit  5.1  to  this  Registration
                        Statement).

     24.1*       --     Power  of  Attorney  (set  forth on the  signature  page
                        contained in Part II of this Registration Statement).

     99.1        --     SunPharm  Corporation  Amended and  Restated  1994 Stock
                        Option Plan  (incorporated by reference to Exhibit 10. 1
                        to the Company's Quarterly Report on Form 10-QSB for the
                        quarter ended June 30, 1997 (File No. 0-27578)).

     99.2        --     SunPharm   Corporation   Amended   and   Restated   1995
                        Non-Employee  Directors' Stock Option Plan (incorporated
                        by reference to Exhibit 10.2 to the Company's  Quarterly
                        Report on Form  10-QSB  for the  quarter  ended June 30,
                        1997 (File No. 0-27578)).

 ---------------------------
* filed herewith

ITEM 9.  UNDERTAKINGS.

                  (a)      The undersigned registrant hereby undertakes:

                  (1) To file,  during any  period in which  offers or sales are
being made, a post-effective amendment to this Registration Statement:

                  (i)  To include any prospectus required by Section 10(a)(3) of
                  the Securities Act of 1933;

                  (ii) To reflect in the  prospectus any facts or events arising
                  after the effective  date of this  Registration  Statement (or
                  the  most  recent  post-effective  amendment  thereof)  which,
                  individually  or in the  aggregate,  represent  a  fundamental
                  change  in the  information  set  forth  in this  Registration
                  Statement;

                  (iii) To include any material  information with respect to the
                  plan  of   distribution   not  previously   disclosed  in  the
                  Registration   Statement  or  any  material   change  to  such
                  information in this Registration Statement;

                  PROVIDED, HOWEVER, that paragraphs (a)(1)(i) and (a)(1)(ii) do
not  apply  if the  information  required  to be  included  in a  post-effective
amendment by those  paragraphs  is contained  in periodic  reports  filed by the
registrant  pursuant to Section 13 or Section 15(d) of the  Securities  Exchange
Act of 1934 that are incorporated by reference in the Registration Statement.

                  (2) That, for the purpose of determining  any liability  under
the Securities Act of 1933, each such  post-effective  amendment shall be deemed
to be a new registration  statement  relating to the securities offered therein,
and the  offering  of such  securities  at that  time  shall be deemed to be the
initial bona fide offering thereof.

                  (3) To remove from  registration by means of a  post-effective
amendment  any of the  securities  being  registered  which remain unsold at the
termination of the offering.

                  (b) The undersigned  registrant  hereby  undertakes  that, for
purposes of determining  any liability  under the  Securities Act of 1933,  each
filing of the  registrant's  annual report pursuant to Section 13(a) or 15(d) of
the Securities  Exchange Act of 1934 that is  incorporated  by reference in this
Registration  Statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

                                      II-3

<PAGE>

                  (c) Insofar as indemnification  for liabilities  arising under
the  Securities  Act of  1933  may  be  permitted  to  directors,  officers  and
controlling persons of the registrant pursuant to the foregoing  provisions,  or
otherwise, the registrant has been advised that in the opinion of the Securities
and  Exchange  Commission  such  indemnification  is  against  public  policy as
expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the
event that a claim for indemnification  against such liabilities (other than the
payment by the registrant of expenses incurred or paid by a director, officer or
controlling  person of the registrant in the  successful  defense of any action,
suit or proceeding) is asserted by such director,  officer or controlling person
in connection with the securities being registered,  the registrant will, unless
in the  opinion  of its  counsel  the matter  has been  settled  by  controlling
precedent,  submit to a court of appropriate  jurisdiction  the question whether
such  indemnification  by it is  against  public  policy  as  expressed  in  the
Securities  Act of 1933 and will be governed by the final  adjudication  of such
issue.

                                      II-4
<PAGE>
                                   SIGNATURES

                  Pursuant to the  requirements  of the  Securities Act of 1933,
the registrant certifies that it has reasonable grounds to believe that it meets
all of the  requirements  for  filing  on  Form  S-8 and has  duly  caused  this
Registration Statement to be signed on its behalf by the undersigned,  thereunto
duly  authorized,  in the  City  of  Jacksonville,  Florida,  on the  9th day of
December, 1997.

                                 SUNPHARM CORPORATION

                                 By: /s/ STEFAN BORG
                                    --------------------------------------------
                                         Stefan Borg
                                         President and Chief Executive Officer

                  KNOW ALL MEN BY THESE  PRESENTS,  that each of the undersigned
officers  and  directors  of  SunPharm   Corporation   (the  "Company")   hereby
constitutes and appoints Stefan Borg as his true and lawful attorney-in-fact and
agent,  with full  power of  substitution,  for him and on his behalf and in his
name, place and stead, in any and all capacities, to sign, execute and file this
Registration  Statement under the Securities Act of 1933, as amended, and any or
all amendments (including, without limitation,  post-effective amendments), with
all  exhibits  and any and all  documents  required  to be  filed  with  respect
thereto,   with  the  Securities  and  Exchange  Commission  or  any  regulatory
authority,  granting  unto  such  attorney-in-fact  and  agent  full  power  and
authority to do and perform each and every act and thing requisite and necessary
to be done in order to effectuate the same, as fully to all intents and purposes
as he,  or his  substitute,  himself  might or could do if  personally  present,
hereby  ratifying and  confirming all that such  attorney-in-fact  and agent may
lawfully do or cause to be done.

                  PURSUANT TO THE  REQUIREMENTS  OF THE  SECURITIES ACT OF 1933,
THIS  REGISTRATION  STATEMENT  HAS BEEN SIGNED BY THE  FOLLOWING  PERSONS IN THE
CAPACITIES AND ON THE DATES INDICATED.

<TABLE>
<CAPTION>
                   SIGNATURE                                         TITLE                                 DATE
                   ---------                                         -----                                 ----

<S>      <C>                                    <C>                                               <C>
/S/      STEFAN BORG                            President, Director and Chief Executive Officer   December 9, 1997
         Stefan Borg                            (PRINCIPAL EXECUTIVE AND ACCOUNTING OFFICER)

/S/      PHILIP R. TRACY                        Chairman of the Board                             December 9, 1997
- --------------------------------------------    of Directors
         Philip R. Tracy

/S/      CHARLES DIMMLER, III                   Director                                          December 9, 1997
- --------------------------------------------
         Charles Dimmler, III

/S/      JERRY T. JACKSON                       Director                                          December 9, 1997
- --------------------------------------------
         Jerry T. Jackson

/S/      ROBERT S. JANICKI                      Director                                          December 9, 1997
- --------------------------------------------
         Robert S. Janicki

/S/      JACQUES F. REJEANGE                    Director                                          December 9, 1997
- --------------------------------------------
         Jacques F. Rejeange

/S/      NORMAN H. LIPOFF                       Director                                          December 9, 1997
- --------------------------------------------
         Norman H. Lipoff

/S/      ROBERT A. SCHOELLHORN                  Director                                          December 9, 1997
- --------------------------------------------
         Robert A. Schoellhorn

/S/      GEORGE B. SCHWARTZ                     Director                                          December 9, 1997
- --------------------------------------------
         George B. Schwartz

/S/      JAY MOORIN                             Director                                          December 9, 1997
- --------------------------------------------
         Jay Moorin

</TABLE>
                                      II-5


                                                                     Exhibit 5.1






                                                 December 9, 1997



Board of Directors
SunPharm Corporation
4651 Salisbury Road, Suite 205
Jacksonville, Florida  32256

Ladies and Gentlemen:

             We have acted as counsel to SunPharm Corporation (the "Company") in
connection  with  the  Company's   Registration   Statement  on  Form  S-8  (the
"Registration  Statement") relating to the registration under the Securities Act
of 1933, as amended,  of the issuance of up to (i) 750,000 shares (the "Employee
Plan  Shares") of the  Company's  common  stock,  $.0001 par value (the  "Common
Stock"),  pursuant to the Company's  Amended and Restated 1994 Stock Option Plan
(the  "Employee  Plan") and (ii) 300,000 shares (the "Director Plan Shares" and,
together with the Employee Plan Shares,  the "Shares") of Common Stock  pursuant
to the Company's Amended and Restated 1995 Non-Employee  Directors' Stock Option
Plan (the "Director Plan").

             In connection  herewith,  we have examined copies of such statutes,
regulations,  corporate  records  and  documents,  certificates  of  public  and
corporate officials and other agreements,  contracts,  documents and instruments
as we have deemed necessary as a basis for the opinion hereafter  expressed.  In
such  examination,  we have  assumed  the  genuineness  of all  signatures,  the
authenticity  of all documents  submitted to us as originals and the  conformity
with the original documents of all documents  submitted to us as copies. We have
also  relied,  to the  extent we deem such  reliance  proper,  upon  information
supplied by  officers  and  employees  of the  Company  with  respect to various
factual matters material to our opinion.

             Based  upon the  foregoing  and  having  due  regard for such legal
considerations  as we deem relevant,  we are of the opinion that the Shares have
been duly authorized,  and that such Shares will, when issued in accordance with
the terms of the Employee Plan or the Director Plan, as  applicable,  be legally
issued, fully paid and nonassessable.

             We hereby  consent to the use of this  opinion as an exhibit to the
Registration Statement.


                                         Very truly yours,

                                         ANDREWS & KURTH L.L.P.






                                                                    Exhibit 23.1



                          INDEPENDENT AUDITORS' CONSENT

             We consent to the  incorporation by reference in this  Registration
Statement  of SunPharm  Corporation  (the  "Company")  on Form S-8 of our report
dated March 14, 1997 (which report expresses an unqualified opinion and includes
an explanatory  paragraph  referring to recurring losses incurred by the Company
from inception and to an uncertainty surrounding the Company's ability to obtain
sufficient  financing in 1997 which raises substantial doubt about the Company's
ability to continue as a going concern),  appearing in the Annual Report on Form
10-KSB of SunPharm Corporation for the year ended December 31, 1996.



DELOITTE & TOUCHE LLP
Jacksonville, Florida

December 9, 1997




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