SYNAPTIC PHARMACEUTICAL CORP
8-K, 1998-08-03
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                           ---------------------------


                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

        Date of report (Date of earliest event reported): August 3, 1998

                       SYNAPTIC PHARMACEUTICAL CORPORATION
               (Exact Name of Registrant as Specified in Charter)

                                    Delaware
                 (State or Other Jurisdiction of Incorporation)

           0-27324                                   22-285-9704
   (Commission File Number)             (I.R.S. Employer Identification No.)

                                215 College Road
                         Paramus, New Jersey 07652-1431
          (Address of principal executive offices, including zip code)

       Registrant's telephone number, including area code: (201) 261-1331


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<PAGE>



Item 5.  Other Events

         On  August  3,  1998,  the  term of the  Company's  collaboration  with
Novartis, which was focused principally on the identification and development of
neuropeptide Y drugs for the treatment of obesity and eating disorders,  as well
as  cardiovascular  disorders,  expired  in  accordance  with  the  terms of the
Research and License  Agreement dated as of August 4, 1994, as amended,  and the
Research and License  Agreement dated as of May 31, 1996. In connection with the
expiration  of the  collaboration,  Novartis'  obligation to provide the Company
with  funding  to  support  a  specified  number  of  the  Company's  scientists
terminated. Novartis continues to have a license under certain patent rights and
to certain  technology of the Company  pursuant to the terms of the Research and
License Agreements.










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<PAGE>


                                   SIGNATURES

                  Pursuant to the requirements of the Securities Exchange Act of
1934,  the  registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.

Date:  August 3, 1998
                                    SYNAPTIC PHARMACEUTICAL CORPORATION
                                    (Registrant)


                                    By:/s/Kathleen P. Mullinix
                                    -------------------------------------------
                                    Name:  Kathleen P. Mullinix
                                    Title: Chairman, President and
                                            Chief Executive Officer










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