SYNAPTIC PHARMACEUTICAL CORP
S-8, 1998-08-10
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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     As filed with the Securities and Exchange Commission on August 10, 1998

                                             Registration No. 333-05793
================================================================================


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                           ---------------------------

                                 POST-EFFECTIVE
                               AMENDMENT NO. 1 TO
                                    FORM S-8
                             REGISTRATION STATEMENT
                        UNDER THE SECURITIES ACT OF 1933


                           ---------------------------

                       Snyaptic Pharmaceutical Corporation
             (Exact name of registrant as specified in its charter)

            Delaware                                        22-2859704
  (State or other jurisdiction of                       (I.R.S. Employer
   incorporation or organization)                       Identification No.)

                                215 College Road
                         Paramus, New Jersey 07652-1431
               (Address of Principal Executive Offices) (Zip Code)

                    1988 Amended and Restated Incentive Plan
                               1996 Incentive Plan
                   1996 Nonemployee Director Stock Option Plan
                            (Full title of the plans)


                              Lisa L. Reiter, Esq.
                       Synaptic Pharmaceutical Corporation
                                215 College Road
                         Paramus, New Jersey 07652-1431
                     (Name and address of agent for service)

                                 (201) 261-1331
          (Telephone number, including area code, of agent for service)

                         CALCULATION OF REGISTRATION FEE


                                    Proposed         Proposed
 Title of                            Maximum          Maximum
Securities                          Offering         Aggregate      Amount of
  to be            Amount to be     Price Per        Offering     Registration
Registered       Registered(1)(2)    Share(3)        Price(3)          Fee
- --------------   ----------------  ----------        ---------    ------------
Common Stock,
$.01 par value    1,000,000 shares  $12.3125       $12,312,500      $3,632.19


         (1) Pursuant to Rule 416(a) of the  Securities  Act of 1933, as amended
         (the  "Act"),  this  registration  statement  shall be  deemed to cover
         additional securities that may be offered or issued to prevent dilution
         resulting from stock splits, stock dividends or similar transactions.

         (2) 1,000,000  additional  shares of Common Stock are being  registered
         hereby  which may be issued as awards or in respect  of awards  granted
         pursuant to the 1996 Incentive Plan, as amended.

         (3) Estimated  solely for the purpose of calculating  the  registration
         fee  pursuant to Rule 457(h) and Rule 457(c) of the Act on the basis of
         the  average of the high and low sales  prices  reported  on the Nasdaq
         National Market on August 5, 1998.



<PAGE>





                                EXPLANATORY NOTE


                  Pursuant  to  General   Instruction   E  of  Form  S-8,   this
Post-effective  Amendment No. 1 to the  Registrant's  Registration  Statement on
Form S-8 (Registration No. 333-05793)  incorporates by reference the contents of
the  earlier  registration  statement  on Form  S-8  which  was  filed  with the
Securities and Exchange Commission on June 12, 1996.



<PAGE>


Item 8. Exhibits.

         4.11     1996 Incentive Plan, as amended  (incorporated by reference to
                  Exhibit A of the Registrant's Proxy Statement, dated April 13,
                  1998, with respect to the Annual Meeting of Stockholders to be
                  held May 12, 1998 (Commission File No. 0-27324)).

         5        Opinion of the  General  Counsel of the  Registrant  as to the
                  validity  of  the  issuance  of the  shares  of  Common  Stock
                  registered hereby.

         23.1     Consent of the General Counsel of the Registrant (included  in
                  Exhibit 5).

         23.2     Consent of Ernst & Young LLP.

         24       Power of Attorney.*

- -----------------
*Previously filed.

                                      II-1



<PAGE>



                                   SIGNATURES


         Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it meets
all of the  requirements  for  filing  on  Form  S-8 and has  duly  caused  this
Registration  Statement  on  Form  S-8  to  be  signed  on  its  behalf  by  the
undersigned, thereunto duly authorized, in the Township of Paramus, State of New
Jersey, on August 10, 1998.

                                          SYNAPTIC PHARMACEUTICAL CORPORATION



                                   By:/s/ Kathleen P. Mullinix
                                      ----------------------------------------
                                 Name:   Kathleen P. Mullinix, Ph.D.
                                Title:   Chairman of the Board,
                                          President and Chief Executive Officer








                                      II-2

<PAGE>



         Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement on Form S-8 has been signed by the following persons
(which  persons  constitute  a  majority  of  the  Board  of  Directors)  in the
capacities and on the dates indicated:

       Signature                      Title                        Date
- ---------------------------       ------------------------     -------------
               
/s/ Kathleen P. Mullinix 
- ------------------------          Chairman of the Board,       August 10, 1998
Kathleen P. Mullinix, Ph.D.       President, Chief Executive
                                  Officer and Director
                                  (Principal Executive
                                  Officer)
          *
- ------------------------
Robert L. Spence                  Chief Financial Officer      August 10, 1998
                                  and Treasurer (Principal
                                  Financial and Accounting
                                  Officer)
          *
- ------------------------
Jonathan J. Fleming               Director                     August 10, 1998

          *
- ------------------------
Zola P. Horovitz, Ph.D.           Director                     August 10, 1998

          *
- ------------------------
Eric R. Kandel, M.D.              Director                     August 10, 1998

          *
- ------------------------
John E. Lyons                     Director                     August 10, 1998

          *
- ------------------------
Sandra Panem, Ph.D.               Director                     August 10, 1998

          *
- ------------------------
Alison Taunton-Rigby, Ph.D.       Director                     August 10, 1998

 


* By:/s/ Kathleen P. Mullinix
     ------------------------
     Kathleen P. Mullinix
     Title: Attorney-in-Fact




                                      II-3

<PAGE>




                                INDEX TO EXHIBITS

        Exhibit
         Number
        -------

         4.11     1996 Incentive Plan, as amended  (incorporated by reference to
                  Exhibit A of the Registrant's Proxy Statement, dated April 13,
                  1998, with respect to the Annual Meeting of Stockholders to be
                  held May 12, 1998 (Commission File No. 0-27324)).

         5        Opinion of the  General  Counsel of the  Registrant  as to the
                  validity  of  the  issuance  of the  shares  of  Common  Stock
                  registered hereby.

         23.1     Consent of the General Counsel of the Registrant (included  in
                  Exhibit 5).

         23.2     Consent of Ernst & Young LLP.

         24       Power of Attorney.*

- -----------------
*Previously filed.






                                                                 EXHIBIT 5
                                                                 ---------

                                                   August 10, 1998



Synaptic Pharmaceutical Corporation
215 College Road
Paramus, New Jersey  07652

Attn: Board of Directors

                  Validity of Additional Share Issuances under
            Synaptic Pharmaceutical Corporation's 1996 Incentive Plan

Ladies and Gentlemen:

         I  am   employed  as  General   Counsel  by   Synaptic   Pharmaceutical
Corporation,  a Delaware  corporation  (the  "Company"),  and have counseled the
Company in connection with the registration under the Securities Act of 1933, as
amended (the "Act"), of an additional  1,000,000 shares (the "Shares") of Common
Stock,  $.01 par value,  of the  Company  for sale to  employees  (as defined in
General  Instruction A to Form S-8 under the Act) pursuant to the Company's 1996
Incentive  Plan, as amended (the "Plan").  Such  registration  is being effected
pursuant  to the  filing  with  the  Securities  and  Exchange  Commission  (the
"Commission")  of a  Post-Effective  Amendment  No. 1 (the  "Amendment")  to the
Registration  Statement  on Form S-8 (No.  333-05793)  which was filed  with the
Commission on June 12, 1996 (the "Registration Statement").

         In that connection,  I have examined originals,  or copies certified or
otherwise  identified to my satisfaction,  of such documents,  corporate records
and other  instruments  as I have  deemed  necessary  for the  purposes  of this
opinion.  In my  examination,  I have assumed the genuineness of all signatures,
the authenticity of all documents  submitted to me by officers of the Company as
originals, the conformity to original documents of all documents submitted to me
as certified or photostatic copies and the authenticity of the originals of such
latter documents.

         Based  upon the  foregoing  and  subject to the  limitations  set forth
below, I am of the opinion that the Shares have been duly  authorized  and, when
issued,  delivered  and paid for in accordance  with the  provisions of the Plan
(and any  applicable  agreement  pertaining  to awards  granted or to be granted
under  the  Plan),   the  Shares  will  be  validly   issued,   fully  paid  and
nonassessable.

         This opinion is furnished to you solely for your benefit in  connection
with the filing of the Amendment  with the  Commission and is not to be used for
any  other  purpose  without  my  prior  written  consent.  Notwithstanding  the
foregoing, I hereby consent to the inclusion of this opinion as Exhibit 5 to the
Amendment  being  filed  by the  Company  with the  Commission.  In  giving  the
foregoing  consent,  I do not admit that I am in the  category of persons  whose
consent is required  under Section 7 of the Act or the rules and  regulations of
the Commission promulgated thereunder.

                                                          Very truly yours,


                                                          /s/Lisa L. Reiter
                                                          ------------------
                                                          Lisa L. Reiter
                                                          General Counsel




                                                               EXHIBIT 23.2
                                                               ------------


                         Consent of Independent Auditors



We consent to the incorporation by reference in the Registration Statement (Form
S-8 No. 333-05793)  pertaining to the 1988 Amended and Restated  Incentive Plan,
the 1996 Incentive Plan and the 1996  Nonemployee  Director Stock Option Plan of
Synaptic  Pharmaceutical  Corporation  of  our  report  dated  January  30, 1998
(except  for the  second  paragraph  of Note 11 as to which the date is March 2,
1998),  with  respect to the  financial  statements  of Synaptic  Pharmaceutical
Corporation  included  in its  Annual  Report  (Form  10-K)  for the year  ended
December 31, 1997, filed with the Securities and Exchange Commission.


                                                     /s/ Ernst & Young LLP


Hackensack, New Jersey
August 6, 1998




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