SYNAPTIC PHARMACEUTICAL CORP
8-K, 1999-04-16
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                           ---------------------------


                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

        Date of report (Date of earliest event reported): April 13, 1999

                       SYNAPTIC PHARMACEUTICAL CORPORATION
               (Exact Name of Registrant as Specified in Charter)

                                    Delaware
                 (State or Other Jurisdiction of Incorporation)

               0-27324                              22-285-9704
       (Commission File Number)         (I.R.S. Employer Identification No.)

                                215 College Road
                         Paramus, New Jersey 07652-1431
          (Address of principal executive offices, including zip code)

       Registrant's telephone number, including area code: (201) 261-1331




                                Page 1 of 5 Pages

<PAGE>



Item 5.           Other Events.

         On April 13, 1999, Synaptic Pharmaceutical  Corporation (the "Company")
issued a press release  announcing the election of Patrick J.  McDonald,  former
Executive Director in Corporate Licensing for Merck & Co., Inc., to its Board of
Directors.  A copy of the press  release is  attached as Exhibit 99 to this Form
8-K and incorporated by reference herein.







Item 7.           Exhibits.

Exhibit No.                                                             Page
- -----------                                                             ----

99                Press Release dated April 13, 1999                      4








                                Page 2 of 5 Pages

<PAGE>




                                   SIGNATURES

                  Pursuant to the requirements of the Securities Exchange Act of
1934,  the  registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.

Date:  April 16, 1999
                                            SYNAPTIC PHARMACEUTICAL CORPORATION
                                            (Registrant)

                                            By: /s/ Kathleen P. Mullinix
                                                -------------------------------
                                          Name:  Kathleen P. Mullinix
                                         Title:  Chairman, President and
                                                  Chief Executive Officer








                                Page 3 of 5 Pages

<PAGE>



                                                               Exhibit No. 99
                                                               --------------



FOR IMMEDIATE RELEASE             Contact: Kathleen P. Mullinix, Ph.D.
                                           Chairman, President and
                                           Chief Executive Officer
                                           Synaptic Pharmaceutical Corporation
                                           (201) 261-1331, ext. 103

                                           Stacy Lipschitz
                                           Ruder Finn, Inc.
                                           (212) 583-2757


               SYNAPTIC PHARMACEUTICAL EXPANDS BOARD OF DIRECTORS

PARAMUS,  NJ,  April 13, 1999 -- Synaptic  Pharmaceutical  Corporation  (Nasdaq:
SNAP) today announced the election of Patrick J. McDonald,  58, to the Company's
Board of Directors. The appointment increases the number of directors to eight.

Mr. McDonald was most recently the Executive Director in Corporate Licensing for
Merck & Co. Inc.,  where he was  responsible  for the successful  negotiation of
licensing   agreements   for  several   products,   as  well  as  for  fostering
relationships  with  external  partners  from  which a number of  compounds  and
technologies  emerged.  Mr.  McDonald's  career at Merck  spanned over 32 years,
where  he  worked  in  a  number  of  different   capacities   including  sales,
advertising,  marketing planning, marketing, business development and licensing.
He was also  instrumental  in  establishing  Merck's first  competitive  product
launch  team;  the  first  report  on  the  U.S.  patient  population  by  major
cardiovascular  disease;  and the  first  predictive  product  launch  model  to
determine the  appropriate  levels of manpower and  promotional  support for new
products.

Kathleen P. Mullinix,  Ph.D.,  chairman,  president and chief executive  officer
commented,  "Pat  is a  well-known  and  highly  respected  professional  in the
pharmaceutical  industry.  His  expansive  career  at Merck,  combined  with his
expertise in product licensing and development of strategic  relationships  will
be invaluable to Synaptic as we continue to build our business."

Synaptic Pharmaceutical  Corporation has developed "human receptor-targeted drug
design  technology," which involves the use of cloned human receptors as targets
for the  design of  potential  drugs.  The  Company  is  collaborating  with the
following  three  pharmaceutical  companies,  all of  which  have  been  granted
licenses in connection with such collaborations  under certain patent rights and
to certain  technologies  of the  company:  Eli Lilly and Company  for  migraine
headache,  depression and obesity;  Grunenthal GmbH for the alleviation of pain;
and Warner-Lambert Company

                                Page 4 of 5 Pages

<PAGE>


for a variety of disorders.  Merck and Co., Inc., Novartis Pharma A.G. and Glaxo
Group Limited have also been granted licenses by the company.

This press release contains  "forward-looking  statements" within the meaning of
Section 27A of the  Securities  Act of 1933 and  Section  21E of the  Securities
Exchange Act of 1934.  Such  statements  include any statements  relating to the
future growth of the Company and any other  statements  that are not  historical
facts.  Such  statements  involve risks and  uncertainties,  including,  but not
limited to, those risks and  uncertainties  relating to the inability to license
potential  products or certain  rights thereto to third parties or to enter into
strategic relationships,  such as collaborative or other licensing arrangements,
and those risks and  uncertainties  detailed in the  Company's  Annual Report on
Form 10-K for the fiscal year ended  December 31, 1998 (the "1998 Form 10-K") or
detailed from time to time in filings the Company makes with the  Securities and
Exchange  Commission.  Although  the  Company  believes  that  the  expectations
reflected in the forward-looking  statements contained herein are reasonable, it
can give no  assurance  that such  expectations  will prove to be  correct.  The
Company  expressly  disclaims any obligation or  undertaking to disseminate  any
updates  or  revisions  to any  forward-looking  statement  contained  herein to
reflect any change in the  Company's  expectations  with  regard  thereto or any
change in events,  conditions or  circumstances  on which any such  statement is
based.


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