TRANSKARYOTIC THERAPIES INC
SC 13G/A, 1997-11-10
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                           (Amendment No.     1    )*

                          Transkaryotic Therapies, Inc.
                                (Name of Issuer)

                     Common Stock, par value $.01 per share
                         (Title of Class of Securities)

                                   893735-10-0
                                 (CUSIP Number)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                       1
<PAGE>

- ----------------------
CUSIP No.  893735-10-0                    13G
- ----------------------

- ---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Warburg, Pincus Capital Company, L.P.
- ---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                      (a) [ ]

                                                                      (b) [X]


- ---------- ---------------------------------------------------------------------
        3  SEC USE ONLY
- ----------
- ---------- --------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- -------------------- ------ ---------------------------------------------------
                         5  SOLE VOTING POWER

                            -0-
                     ------ ---------------------------------------------------
     NUMBER OF           6  SHARED VOTING POWER
      SHARES
   BENEFICIALLY             4,399,745
     OWNED BY
                     ------ ---------------------------------------------------
       EACH              7  SOLE DISPOSITIVE POWER
     REPORTING
      PERSON                -0-
       WITH
                     ------ ---------------------------------------------------
                           8 SHARED DISPOSITIVE POWER

                            4,399,745
- ---------- --------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           4,399,745
- ---------- --------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
- ---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           23.5%
- ---------- --------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           PN
- ---------- ---------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                                       2
<PAGE>


- ---------------------
CUSIP No. 893735-10-0                  13G
- ---------------------
- ---------- --------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           E.M. Warburg, Pincus & Co., LLC
- ---------- --------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                  (a) [ ]

                                                                  (b) [X]


- ---------- ---------------------------------------------------------------------
        3  SEC USE ONLY

- ---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           New York
- -------------------- ------ ----------------------------------------------------
                         5  SOLE VOTING POWER

                            -0-
                     ------ ----------------------------------------------------
     NUMBER OF           6  SHARED VOTING POWER
      SHARES
   BENEFICIALLY             4,399,745
     OWNED BY
                     ------ ----------------------------------------------------
       EACH              7  SOLE DISPOSITIVE POWER
     REPORTING
      PERSON                -0-
       WITH
                     ------ ----------------------------------------------------
                           8 SHARED DISPOSITIVE POWER

                            4,399,745
- ---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           4,399,745
- ---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
- ---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           23.5%
- ---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           OO
- ---------- ---------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                                       3
<PAGE>


- ---------------------
CUSIP No. 893735-10-0             13G
- ---------------------

- ---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Warburg, Pincus & Co.
- ---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a) [ ]

                                                                       (b) [X]

- ---------- ---------------------------------------------------------------------
        3  SEC USE ONLY

- ---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           New York
- -------------------- ------ ----------------------------------------------------
                         5  SOLE VOTING POWER

                            -0-
                     ------ ----------------------------------------------------
     NUMBER OF           6  SHARED VOTING POWER
      SHARES
   BENEFICIALLY             4,399,745
     OWNED BY
                     ------ ----------------------------------------------------
       EACH              7  SOLE DISPOSITIVE POWER
     REPORTING
      PERSON                -0-
       WITH
                     ------ ----------------------------------------------------
                           8 SHARED DISPOSITIVE POWER

                            4,399,745
- ---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           4,399,745
- ---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
- ---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           23.5%
- ---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           PN
- ---------- ---------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                                       4
<PAGE>

Item 1(a).                    Name of Issuer:

                              Transkaryotic Therapies, Inc. (the "Issuer")

Item 1(b).                    Address of Issuer's Principal Executive Offices:

                              195 Albany Street 
                              Cambridge, Massachusetts 02139

Items 2(a)                    Name of Person Filing; Address of Principal
and (b).                      Business Office:

                              This  statement  is filed by and on  behalf of (a)
                              Warburg,  Pincus Capital Company, L.P., a Delaware
                              limited  partnership  ("WPCC");  (b) E.M. Warburg,
                              Pincus & Co.,  LLC, a New York  limited  liability
                              company  ("EMW LLC");  and (c)  Warburg,  Pincus &
                              Co., a New York general  partnership  ("WP").  The
                              sole  general  partner  of  WPCC  is WP.  EMW  LLC
                              manages   WPCC.   The   members  of  EMW  LLC  are
                              substantially  the  same  as the  partners  of WP.
                              Lionel I. Pincus is the managing partner of WP and
                              the  managing  member of EMW LLC and may be deemed
                              to  control  both WP and EMW LLC.  WP, as the sole
                              general partner of WPCC, has a 20% interest in the
                              profits of WPCC.  The business  address of each of
                              the foregoing is 466 Lexington  Avenue,  New York,
                              New York 10017.

                              WPCC, EMW LLC and WP are collectively  referred to
                              herein as the "Reporting Entities."

Item 2(c).                    Citizenship:

                              Not Applicable.

Item 2(d).                    Title of Class of Securities:

                              Common  Stock,  $.01  par  value  per  share  (the
                              "Common Stock").

Item 2(e).                    CUSIP Number:

                              893735-10-0

Item 3.                       Not Applicable.


                                       5
<PAGE>


Item 4.                       Ownership:

                              (a)  4,399,745  shares  of  Common  Stock,  as  of
                              October 31, 19971.

                              (b)     23.5%

                              (c)     (i)      -0-
                                      (ii)     4,399,745
                                      (iii)    -0-
                                      (iv)     4,399,745

Item 5.                       Ownership of Five Percent or Less of a Class:

                                 Not Applicable.

Item 6.                       Ownership of More than Five Percent on Behalf
                               of Another Person:

Not                           Applicable.

Item 7.                       Identification    and    Classification   of   the
                              Subsidiary   Which  Acquired  the  Security  Being
                              Reported  on By the Parent  Holding  Company:  Not
                              Applicable.

Item 8.                       Identification  and  Classification  of Members of
                              the Group:

                              The  agreement  required by Rule  13d-1(f)(1)(iii)
                              was  previously  filed with the Schedule 13G being
                              amended hereby dated February 10, 1997.

Item 9.                       Notice of Dissolution of Group:

                              Not Applicable.

Item 10.                      Certification:

                              Not Applicable.

                                       6
<PAGE>




                                    SIGNATURE

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated:  November 7, 1997

                                        WARBURG, PINCUS CAPITAL COMPANY, L.P.

                                        By:   Warburg, Pincus & Co.,
                                              its General Partner


                                       By:/s/ Stephen Distler
                                          ---------------------------------
                                               Stephen Distler, Partner


                                        WARBURG, PINCUS & CO.


                                       By:/s/ Stephen Distler          
                                          ------------------------------
                                             Stephen Distler, Partner


                                        E.M. WARBURG, PINCUS & CO., LLC


                                       By: /s/ Stephen Distler         
                                          ------------------------------
                                             Stephen Distler, Member

 

                                      7



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