TRANSKARYOTIC THERAPIES INC
SC 13G/A, 1998-02-12
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
Previous: BUCKLE INC, SC 13G/A, 1998-02-12
Next: VMARK SOFTWARE INC, 8-K, 1998-02-12



<PAGE>


                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                    -----------------------------------------
                               (Amendment No. 2 )*

                          Transkaryotic Therapies, Inc.
                          -----------------------------
                                (Name of Issuer)

                     Common Stock, par value $.01 per share
                     --------------------------------------
                         (Title of Class of Securities)

                                   893735-10-0
                                   -----------
                                 (CUSIP Number)

  *The remainder of this cover page shall be filled out for a reporting person's
  initial  filing on this form with respect to the subject class of  securities,
  and for any subsequent amendment containing  information which would alter the
  disclosures provided in a prior cover page.

  The  information  required  on the  remainder  of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities  Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
  the Act but shll be subject to all other  provisions of the Act (however,  see
  the Notes).

                                       1
<PAGE>






- --------------------------------------------                                 
CUSIP No.  893735-10-0                            13G                     
          ------------------------------         -----
- --------------------------------------------                                 

- ---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Warburg, Pincus Capital Company, L.P.
- ---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                           (a)[ ]
                                                           (b)[X]
          
- ---------- ---------------------------------------------------------------------
        3  SEC USE ONLY

- ---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- -------------------- ------ ----------------------------------------------------
                         5  SOLE VOTING POWER

                            -0-
                     ------ ----------------------------------------------------
     NUMBER OF           6  SHARED VOTING POWER
      SHARES
   BENEFICIALLY             4,349,152
     OWNED BY
                     ------ ----------------------------------------------------
       EACH              7  SOLE DISPOSITIVE POWER
     REPORTING
      PERSON                -0-
       WITH
                     ------ ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            4,349,152
- ---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           4,349,152
- ---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

- ---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           23.6%
- ---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           PN
- ---------- ---------------------------------------------------------------------




                      *SEE INSTRUCTION BEFORE FILLING OUT!


                                       2
<PAGE>



- --------------------------------------------                                   
CUSIP No. 893735-10-0                                           13G            
          -----------                                                          
- --------------------------------------------                                   

- ---------- --------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           E.M. Warburg, Pincus & Co., LLC
- ---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)[ ]
                                                          (b)[X]
           ---------------------------------------------------------------------
                                                                             
- ---------- ---------------------------------------------------------------------
        3  SEC USE ONLY
- ----------
- ---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           New York
- -------------------- ------ ----------------------------------------------------
                         5  SOLE VOTING POWER

                            -0-
                     ------ ----------------------------------------------------
     NUMBER OF           6  SHARED VOTING POWER
      SHARES
   BENEFICIALLY             4,349,152
     OWNED BY
                     ------ ----------------------------------------------------
       EACH              7  SOLE DISPOSITIVE POWER
     REPORTING
      PERSON                -0-
       WITH
                     ------ ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            4,349,152
- ---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           4,349,152
- ---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

- ---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           23.6%
- ---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           OO
- ---------- ---------------------------------------------------------------------



                      *SEE INSTRUCTION BEFORE FILLING OUT!



                                       3
<PAGE>



- --------------------------------------------                                    
CUSIP No. 893735-10-0                                           13G             
          -----------                                          ----
- --------------------------------------------                                    

- ---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Warburg, Pincus & Co.
- ---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                           (a)[ ]
                                                           (b)[X]
                                                                            

- ---------- ---------------------------------------------------------------------
        3  SEC USE ONLY

- ---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           New York
- -------------------- ------ ----------------------------------------------------
                         5  SOLE VOTING POWER

                            -0-
                     ------ ----------------------------------------------------
     NUMBER OF           6  SHARED VOTING POWER
      SHARES
   BENEFICIALLY             4,349,152
     OWNED BY
                     ------ ----------------------------------------------------
       EACH              7  SOLE DISPOSITIVE POWER
     REPORTING
      PERSON                -0-
       WITH
                     ------ ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            4,349,152
- ---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           4,349,152
- ---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

- ---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           23.6%
- ---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           PN
- ---------- ---------------------------------------------------------------------






                      *SEE INSTRUCTION BEFORE FILLING OUT!


                                       4
<PAGE>


Item 1(a).                         Name of Issuer:

                                   Transkaryotic Therapies, Inc. (the "Issuer")

Item 1(b).                         Address of Issuer's Principal Executive 
                                   Offices:

                                   195 Albany Street
                                   Cambridge, Massachusetts 02139

Items 2(a)                         Name of Person Filing; Address of Principal
and (b).                           Business Office:

                                   This  statement  is filed by and on behalf of
                                   (a) Warburg,  Pincus Capital Company, L.P., a
                                   Delaware limited  partnership  ("WPCC");  (b)
                                   E.M.  Warburg,  Pincus & Co., LLC, a New York
                                   limited  liability  company ("EMW LLC");  and
                                   (c) Warburg, Pincus & Co., a New York general
                                   partnership  ("WP"). The sole general partner
                                   of WPCC  is WP.  EMW LLC  manages  WPCC.  The
                                   members of EMW LLC are substantially the same
                                   as the  partners  of WP.  Lionel I. Pincus is
                                   the  managing  partner of WP and the managing
                                   member  of  EMW  LLC  and  may be  deemed  to
                                   control  both WP and EMW LLC. WP, as the sole
                                   general  partner of WPCC,  has a 20% interest
                                   in the profits of WPCC. The business  address
                                   of each  of the  foregoing  is 466  Lexington
                                   Avenue, New York, New York 10017.

                                   WPCC,   EMW  LLC  and  WP  are   collectively
                                   referred   to   herein   as  the   "Reporting
                                   Entities."

Item 2(c).                         Citizenship:

                                   Not Applicable.

Item 2(d).                         Title of Class of Securities:

                                   Common  Stock,  $.01 par value per share (the
                                   "Common Stock").

Item 2(e).                         CUSIP Number:

                                   893735-10-0

Item 3.                            Not Applicable.

                                       5
<PAGE>

Item 4.                            Ownership:

                                   (a) 4,349,152  shares of Common Stock,  as of
                                       December 31, 19971.

                                    (b)     23.6%

                                    (c)     (i)      -0-
                                           (ii)      4,349,152
                                           (iii)     -0-
                                           (iv)      4,349,152

Item 5.                            Ownership of Five Percent or Less of a Class:

                                   Not Applicable.

Item 6.                            Ownership  of More than Five Percent
                                   on Behalf of Another Person:

                                   Not Applicable.

Item 7.                            Identification and Classification of the
                                   Subsidiary Which Acquired the Security Being
                                   Reported on By the Parent Holding Company:

                                   Not Applicable.

Item 8.                            Identification and Classification of Members 
                                   of the Group:

                                   The     agreement     required     by    Rule
                                   13d-1(f)(1)(iii)  was  previously  filed with
                                   the Schedule 13G being further amended hereby
                                   dated February 10, 1997.

Item 9.                            Notice of Dissolution of Group:

                                   Not Applicable.

Item 10.                           Certification:

                                   Not Applicable.

- ---------------------------------
1    Includes 77,181 shares of Common Stock which may be acquired within 60 days
     by  each  of the  Reporting  Entities  upon  the  exercise  of  outstanding
     warrants.

                                       6
<PAGE>


                                    SIGNATURE

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated:  February 11, 1998

                                   WARBURG, PINCUS CAPITAL COMPANY, L.P.

                                   By:  Warburg, Pincus & Co.,
                                        its General Partner


                                   By: /s/ Stephen Distler
                                       --------------------
                                       Stephen Distler, Partner


                                   WARBURG, PINCUS & CO.


                                   By: /s/ Stephen Distler
                                      --------------------
                                       Stephen Distler, Partner


                                   E.M. WARBURG, PINCUS & CO., LLC


                                   By: /s/ Stephen Distler
                                       --------------------
                                       Stephen Distler, Member


                                       7
<PAGE>


© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission